albiglutide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Glucagon-like Peptide (GLP) analogues 4927 782500-75-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • albiglutide
  • tanzeum
  • GSK-716155
  • GSK716155
  • albugon
A long-acting glucagon-like peptide-1 (GLP-1) receptor agonist, with antihyperglycemic activity. Albiglutide is composed of a GLP-1 (7-36) dimer fused to recombinant human albumin. Upon subcutaneous administration, this agent has a half-life of 4-7 days and resists degradation by dipeptidyl peptidase-4 (DPP-4).
  • Molecular weight: 3284.64
  • Formula: C148H223N39O46
  • CLOGP:
  • LIPINSKI: None
  • HAC: 85
  • HDO: 49
  • TPSA: 1379.30
  • ALOGS: -4.84
  • ROTB: 108

Drug dosage:

DoseUnitRoute
5.70 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 15, 2014 FDA GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device use error 318.59 49.23 52 376 5214 50599482
Device leakage 59.61 49.23 13 415 5865 50598831

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device use error 213.41 58.68 34 311 2088 29572094

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device use error 282.41 43.51 50 622 6421 64491639
Product preparation error 44.91 43.51 10 662 3995 64494065

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BJ04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Glucagon-like peptide-1 (GLP-1) analogues
FDA MoA N0000020058 Glucagon-like Peptide-1 (GLP-1) Agonists
MeSH PA D006728 Hormones
MeSH PA D054795 Incretins
FDA EPC N0000178480 GLP-1 Receptor Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Multiple endocrine neoplasia, type 2 contraindication 61808009
Medullary thyroid carcinoma contraindication 255032005 DOID:3973
History of medullary carcinoma of thyroid contraindication 429016002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.01 acidic
pKa2 3.31 acidic
pKa3 3.82 acidic
pKa4 4.11 acidic
pKa5 4.44 acidic
pKa6 9.65 acidic
pKa7 11.88 acidic
pKa8 12.25 acidic
pKa9 12.57 acidic
pKa10 12.65 acidic
pKa11 12.88 acidic
pKa12 12.95 acidic
pKa13 13.05 acidic
pKa14 13.2 acidic
pKa15 13.23 acidic
pKa16 13.38 acidic
pKa17 13.39 acidic
pKa18 13.55 acidic
pKa19 13.56 acidic
pKa20 13.67 acidic
pKa21 13.75 acidic
pKa22 13.8 acidic
pKa23 13.91 acidic
pKa24 12.18 Basic
pKa25 11.11 Basic
pKa26 10.51 Basic
pKa27 7.86 Basic
pKa28 5.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucagon-like peptide 1 receptor GPCR AGONIST EC50 9.70 SCIENTIFIC LITERATURE DRUG LABEL
Glucagon-like peptide 1 receptor GPCR AGONIST EC50 7.70 IUPHAR

External reference:

IDSource
D08843 KEGG_DRUG
4033416 VUID
N0000190764 NUI
4033416 VANDF
CHEBI:78425 CHEBI
CHEMBL2107841 ChEMBL_ID
C534611 MESH_SUPPLEMENTAL_RECORD_UI
7386 IUPHAR_LIGAND_ID
8829 INN_ID
DB09043 DRUGBANK_ID
5E7U48495E UNII
145994868 PUBCHEM_CID
1534763 RXNORM
216723 MMSL
30258 MMSL
d08251 MMSL
015507 NDDF
703129009 SNOMEDCT_US
703905003 SNOMEDCT_US
C2607479 UMLSCUI

Pharmaceutical products:

None