pembrolizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4924 1374853-91-4

Description:

MoleculeDescription

Synonyms:

  • pembrolizumab
  • keytruda
  • lambrolizumab
  • SCH-900475
  • MK-3475
  • pembrolizumab (genetical recombination)
A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1) with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, pembrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells. The ligands for PD-1 include programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs. Activated PD-1 negatively regulates T-cell activation and plays a key role in in tumor evasion from host immunity.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
9.50 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Sept. 28, 2016 PMDA MSD K.K.
July 17, 2015 EMA Merck Sharp & Dohme Limited
Sept. 4, 2014 FDA MERCK SHARP DOHME

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 9414.77 14.72 3822 102904 103048 90418673
Hypothyroidism 3401.80 14.72 1520 105206 51607 90470114
Immune-mediated hypothyroidism 1670.52 14.72 384 106342 1174 90520547
Immune-mediated hepatic disorder 1669.26 14.72 394 106332 1398 90520323
Immune-mediated enterocolitis 1525.90 14.72 449 106277 4308 90517413
Myocarditis 1425.51 14.72 556 106170 13250 90508471
Therapy partial responder 1387.74 14.72 624 106102 21419 90500302
Adrenal insufficiency 1308.05 14.72 659 106067 29262 90492459
Immune-mediated myocarditis 1295.44 14.72 303 106423 1022 90520699
Palmar-plantar erythrodysaesthesia syndrome 1166.05 14.72 597 106129 27426 90494295
Immune-mediated adrenal insuficiency 1161.70 14.72 267 106459 815 90520906
Proteinuria 1041.49 14.72 521 106205 22770 90498951
Thyroiditis 1013.55 14.72 308 106418 3329 90518392
Immune-mediated hepatitis 1006.44 14.72 292 106434 2652 90519069
Hyperthyroidism 979.40 14.72 463 106263 17847 90503874
Immune-mediated adverse reaction 921.40 14.72 212 106514 651 90521070
Immune-mediated lung disease 910.58 14.72 245 106481 1635 90520086
Neutropenia 897.30 14.72 1210 105516 223694 90298027
Immune-mediated dermatitis 879.12 14.72 207 106519 724 90520997
Tubulointerstitial nephritis 796.21 14.72 448 106278 24895 90496826
Pneumonitis 779.09 14.72 541 106185 43629 90478092
Platelet count decreased 778.50 14.72 881 105845 136088 90385633
Type 1 diabetes mellitus 752.25 14.72 263 106463 4549 90517172
Hypertension 744.69 14.72 1653 105073 455879 90065842
Interstitial lung disease 712.94 14.72 643 106083 75762 90445959
Colitis 693.07 14.72 609 106117 69333 90452388
Hepatic function abnormal 674.68 14.72 505 106221 45783 90475938
Tumour pseudoprogression 663.48 14.72 157 106569 564 90521157
Hepatic cytolysis 644.20 14.72 420 106306 30496 90491225
Radiotherapy 613.02 14.72 155 106571 780 90520941
Neuropathy peripheral 595.08 14.72 769 105957 136201 90385520
Immune-mediated thyroiditis 586.43 14.72 133 106593 375 90521346
Hypophysitis 578.52 14.72 184 106542 2336 90519385
Adrenocorticotropic hormone deficiency 566.89 14.72 140 106586 628 90521093
Febrile neutropenia 559.15 14.72 804 105922 157545 90364176
Myelosuppression 529.55 14.72 466 106260 53125 90468596
Death 509.29 14.72 1429 105297 455122 90066599
Product use in unapproved indication 441.93 14.72 1119 105607 335117 90186604
Immune-mediated pancreatitis 431.13 14.72 98 106628 280 90521441
Immune-mediated encephalitis 427.36 14.72 104 106622 433 90521288
Joint swelling 425.45 14.72 48 106678 503252 90018469
Immune-mediated hyperthyroidism 420.87 14.72 96 106630 280 90521441
Thrombocytopenia 388.95 14.72 798 105928 207927 90313794
Renal impairment 384.73 14.72 544 106182 104877 90416844
Blood thyroid stimulating hormone increased 380.51 14.72 195 106531 8960 90512761
Lichenoid keratosis 378.87 14.72 134 106592 2400 90519321
Abdominal discomfort 378.16 14.72 56 106670 477272 90044449
Immune-mediated renal disorder 376.76 14.72 80 106646 146 90521575
Immune-mediated hypophysitis 373.56 14.72 93 106633 434 90521287
Pyrexia 363.22 14.72 1638 105088 658847 89862874
Swelling 359.04 14.72 38 106688 419020 90102701
Pain 355.54 14.72 391 106335 995950 89525771
Contraindicated product administered 351.04 14.72 5 106721 320134 90201587
Troponin increased 340.89 14.72 206 106520 13075 90508646
Synovitis 338.79 14.72 11 106715 329741 90191980
Arthropathy 338.74 14.72 24 106702 366218 90155503
Immune-mediated myositis 324.23 14.72 118 106608 2303 90519418
Systemic lupus erythematosus 322.69 14.72 28 106698 361868 90159853
Nasopharyngitis 321.82 14.72 48 106678 407056 90114665
Hepatitis 320.84 14.72 406 106320 70333 90451388
Glossodynia 316.12 14.72 15 106711 321764 90199957
Wound 308.09 14.72 11 106715 302969 90218752
Acute kidney injury 306.10 14.72 950 105776 319437 90202284
Maternal exposure during pregnancy 304.94 14.72 34 106692 360029 90161692
Pancytopenia 301.25 14.72 522 106204 119741 90401980
Decreased appetite 293.37 14.72 1042 105684 375498 90146223
Immune-mediated arthritis 293.05 14.72 68 106658 219 90521502
Immune-mediated gastritis 289.37 14.72 63 106663 137 90521584
Therapeutic product effect decreased 286.02 14.72 9 106717 277562 90244159
Gastrointestinal perforation 283.22 14.72 126 106600 4206 90517515
Fulminant type 1 diabetes mellitus 282.06 14.72 83 106643 795 90520926
Sinusitis 281.62 14.72 36 106690 343052 90178669
Weight increased 278.77 14.72 74 106652 417853 90103868
Nephritis 278.69 14.72 114 106612 3081 90518640
Skin toxicity 274.81 14.72 142 106584 6637 90515084
Neutrophil count decreased 269.62 14.72 375 106351 71157 90450564
Cholangitis 267.09 14.72 142 106584 7040 90514681
Myasthenia gravis 265.32 14.72 139 106587 6686 90515035
Immune-mediated nephritis 264.25 14.72 69 106657 403 90521318
Hepatotoxicity 261.95 14.72 296 106430 45546 90476175
Anaemia 256.69 14.72 955 105771 351847 90169874
Glucocorticoid deficiency 255.39 14.72 70 106656 505 90521216
Drug hypersensitivity 252.71 14.72 115 106611 463494 90058227
Immune-mediated cholangitis 250.69 14.72 60 106666 229 90521492
Exposure during pregnancy 248.27 14.72 7 106719 238403 90283318
Diarrhoea 247.60 14.72 1919 104807 937271 89584450
Thyroid disorder 245.66 14.72 188 106538 17597 90504124
Peripheral swelling 245.36 14.72 90 106636 413016 90108705
Eastern Cooperative Oncology Group performance status worsened 242.99 14.72 90 106636 1849 90519872
Discomfort 239.71 14.72 23 106703 274312 90247409
Drug ineffective 237.53 14.72 838 105888 1383460 89138261
Drug intolerance 234.78 14.72 117 106609 447474 90074247
Secondary adrenocortical insufficiency 230.87 14.72 91 106635 2227 90519494
Musculoskeletal stiffness 229.61 14.72 37 106689 296495 90225226
Hypopituitarism 229.40 14.72 84 106642 1669 90520052
Encephalitis 228.77 14.72 150 106576 10984 90510737
Immune-mediated endocrinopathy 226.97 14.72 48 106678 85 90521636
Renal tubular necrosis 225.89 14.72 165 106561 14390 90507331
Hypersensitivity 225.04 14.72 128 106598 454549 90067172
Dizziness 224.60 14.72 218 106508 589066 89932655
Irritable bowel syndrome 224.12 14.72 4 106722 207444 90314277
Cytokine release syndrome 223.30 14.72 216 106510 27757 90493964
Psoriatic arthropathy 223.04 14.72 11 106715 228324 90293397
Haemophagocytic lymphohistiocytosis 221.43 14.72 167 106559 15292 90506429
Skin disorder 219.98 14.72 243 106483 36463 90485258
Inappropriate schedule of product administration 217.71 14.72 519 106207 149414 90372307
Contusion 217.02 14.72 22 106704 251194 90270527
Wheezing 210.55 14.72 19 106707 238061 90283660
Injury 208.45 14.72 5 106721 197344 90324377
Lower respiratory tract infection 206.36 14.72 26 106700 250633 90271088
Intentional product use issue 203.98 14.72 13 106713 216879 90304842
Condition aggravated 203.89 14.72 241 106485 595304 89926417
Folliculitis 202.33 14.72 9 106717 204344 90317377
Blood cholesterol increased 200.08 14.72 11 106715 208001 90313720
Autoimmune hepatitis 199.49 14.72 134 106592 10217 90511504
Depression 198.88 14.72 54 106672 300547 90221174
Enterocolitis 197.87 14.72 134 106592 10356 90511365
Headache 195.35 14.72 457 106269 862289 89659432
Autoimmune colitis 195.35 14.72 61 106665 726 90520995
Muscle injury 192.51 14.72 3 106723 176651 90345070
Intestinal perforation 190.11 14.72 146 106580 13735 90507986
Cortisol decreased 189.14 14.72 73 106653 1686 90520035
Fall 188.45 14.72 174 106552 481636 90040085
Asthma 187.92 14.72 30 106696 242130 90279591
Adrenal disorder 186.04 14.72 74 106652 1856 90519865
Dysphonia 183.57 14.72 293 106433 62791 90458930
Myositis 182.67 14.72 181 106545 23947 90497774
Tumour hyperprogression 182.50 14.72 42 106684 129 90521592
Cholecystitis 179.99 14.72 154 106572 16886 90504835
Mobility decreased 179.67 14.72 38 106688 250696 90271025
Diabetic ketoacidosis 177.24 14.72 179 106547 24228 90497493
Cardiac failure 176.48 14.72 395 106331 109101 90412620
Neoplasm progression 176.30 14.72 239 106487 44247 90477474
Vitiligo 176.27 14.72 73 106653 2037 90519684
Infusion related reaction 175.77 14.72 140 106586 416640 90105081
Urogenital fistula 174.50 14.72 50 106676 432 90521289
Mucosal inflammation 173.69 14.72 272 106454 57353 90464368
Febrile bone marrow aplasia 173.28 14.72 120 106606 9618 90512103
Pericarditis 172.28 14.72 52 106674 270099 90251622
Osteoarthritis 172.03 14.72 16 106710 195714 90326007
Insomnia 169.07 14.72 91 106635 333383 90188338
Migraine 168.85 14.72 15 106711 190377 90331344
Small intestinal perforation 168.83 14.72 69 106657 1860 90519861
Toxic epidermal necrolysis 167.32 14.72 199 106527 32329 90489392
Rash maculo-papular 166.93 14.72 223 106503 40710 90481011
Blood corticotrophin decreased 160.02 14.72 48 106678 494 90521227
Erythema multiforme 159.43 14.72 125 106601 12121 90509600
Impaired healing 158.83 14.72 40 106686 234159 90287562
Injection site pain 158.70 14.72 12 106714 173687 90348034
Immune-mediated neuropathy 158.07 14.72 35 106691 85 90521636
Pulmonary toxicity 157.29 14.72 121 106605 11410 90510311
Myasthenic syndrome 156.99 14.72 44 106682 348 90521373
Drug eruption 155.40 14.72 200 106526 35207 90486514
Treatment failure 152.51 14.72 84 106642 303844 90217877
Autoimmune thyroiditis 150.17 14.72 91 106635 5802 90515919
Malaise 145.33 14.72 1182 105544 584804 89936917
Muscle spasms 144.23 14.72 58 106668 251825 90269896
Confusional state 142.22 14.72 147 106579 386058 90135663
Alopecia 140.60 14.72 229 106497 494842 90026879
Bursitis 140.31 14.72 3 106723 131651 90390070
Immune-mediated cytopenia 138.39 14.72 31 106695 81 90521640
Rheumatoid arthritis 136.96 14.72 135 106591 362479 90159242
Radiation pneumonitis 134.29 14.72 58 106668 1800 90519921
Posterior reversible encephalopathy syndrome 134.03 14.72 148 106578 22191 90499530
Drug interaction 132.16 14.72 81 106645 276372 90245349
Joint range of motion decreased 127.89 14.72 8 106718 135635 90386086
Immune thrombocytopenia 127.80 14.72 114 106612 13212 90508509
Silent thyroiditis 125.70 14.72 31 106695 138 90521583
Dermatitis bullous 125.10 14.72 101 106625 10215 90511506
Hypothalamo-pituitary disorder 123.60 14.72 58 106668 2194 90519527
Type 2 diabetes mellitus 122.71 14.72 43 106683 203201 90318520
Stevens-Johnson syndrome 121.24 14.72 161 106565 29215 90492506
Pain in extremity 119.12 14.72 218 106508 450311 90071410
Blister 118.73 14.72 77 106649 254921 90266800
Cardiotoxicity 116.36 14.72 101 106625 11288 90510433
Bronchitis 116.26 14.72 20 106706 152907 90368814
Autoimmune hypothyroidism 114.07 14.72 32 106694 254 90521467
Large intestine perforation 113.37 14.72 93 106633 9619 90512102
Cholestasis 110.29 14.72 172 106554 36127 90485594
Pemphigoid 108.67 14.72 88 106638 8938 90512783
Sleep disorder 107.92 14.72 49 106677 197981 90323740
Troponin I increased 107.84 14.72 55 106671 2500 90519221
C-reactive protein abnormal 107.84 14.72 12 106714 127417 90394304
Memory impairment 107.19 14.72 49 106677 197195 90324526
Night sweats 106.79 14.72 13 106713 128753 90392968
Tumour associated fever 106.64 14.72 34 106692 435 90521286
Blood thyroid stimulating hormone decreased 105.11 14.72 72 106654 5668 90516053
Lip dry 104.91 14.72 3 106723 100952 90420769
Anxiety 104.06 14.72 127 106599 309645 90212076
Ascites 102.60 14.72 194 106532 47546 90474175
Road traffic accident 102.51 14.72 6 106720 107620 90414101
Injection site erythema 102.09 14.72 3 106723 98499 90423222
Adrenocortical insufficiency acute 101.17 14.72 53 106673 2548 90519173
Prescribed overdose 101.09 14.72 3 106723 97622 90424099
Immune-mediated cystitis 100.86 14.72 21 106705 33 90521688
Loss of personal independence in daily activities 98.75 14.72 20 106706 136085 90385636
Wound infection 98.17 14.72 7 106719 106395 90415326
Hypercholesterolaemia 98.03 14.72 5 106721 100887 90420834
Thyrotoxic crisis 97.49 14.72 41 106685 1190 90520531
Hypertransaminasaemia 96.94 14.72 106 106620 15719 90506002
Immune-mediated uveitis 95.87 14.72 24 106702 115 90521606
Urticaria 95.07 14.72 138 106588 312596 90209125
Immune-mediated neurological disorder 94.58 14.72 19 106707 22 90521699
Overdose 94.10 14.72 34 106692 157675 90364046
Cerebral infarction 93.61 14.72 135 106591 26461 90495260
Subacute cutaneous lupus erythematosus 93.04 14.72 56 106670 3526 90518195
Guillain-Barre syndrome 91.99 14.72 61 106665 4551 90517170
Obesity 91.68 14.72 9 106717 105498 90416223
Immune-mediated oesophagitis 91.47 14.72 18 106708 17 90521704
Sciatica 89.82 14.72 8 106718 101374 90420347
Hypoaesthesia 89.42 14.72 145 106581 314065 90207656
Abdominal pain upper 88.74 14.72 160 106566 332514 90189207
Nephrotic syndrome 87.19 14.72 71 106655 7268 90514453
Lower limb fracture 86.63 14.72 3 106723 85010 90436711
Product dose omission issue 86.43 14.72 131 106595 291556 90230165
Alanine aminotransferase increased 85.52 14.72 320 106406 118018 90403703
Cytopenia 85.23 14.72 104 106622 17345 90504376
Adrenalitis 83.69 14.72 18 106708 36 90521685
Rectal perforation 83.06 14.72 29 106697 499 90521222
Medication error 82.87 14.72 4 106722 84648 90437073
Cardiac dysfunction 82.64 14.72 52 106674 3545 90518176
Blood corticotrophin increased 82.34 14.72 21 106705 110 90521611
Primary adrenal insufficiency 81.92 14.72 25 106701 274 90521447
Gastrooesophageal reflux disease 81.90 14.72 47 106679 166290 90355431
Nephropathy toxic 81.24 14.72 87 106639 12601 90509120
Knee arthroplasty 81.21 14.72 4 106722 83178 90438543
Autoimmune pancreatitis 80.96 14.72 26 106700 341 90521380
Product use issue 80.74 14.72 664 106062 329255 90192466
Red blood cell sedimentation rate increased 80.54 14.72 4 106722 82591 90439130
Cholangitis sclerosing 80.01 14.72 43 106683 2178 90519543
Cardiomyopathy 79.20 14.72 108 106618 20098 90501623
Gait inability 78.60 14.72 37 106689 146419 90375302
Meningitis 78.26 14.72 71 106655 8410 90513311
Dyspnoea 78.25 14.72 663 106063 880292 89641429
Upper respiratory tract infection 77.68 14.72 27 106699 128291 90393430
Autoimmune nephritis 77.39 14.72 26 106700 396 90521325
Dyspepsia 76.81 14.72 72 106654 198088 90323633
Disseminated intravascular coagulation 76.79 14.72 110 106616 21428 90500293
Suicide attempt 75.66 14.72 3 106723 75396 90446325
Toxic skin eruption 75.40 14.72 93 106633 15681 90506040
Renal failure 75.34 14.72 330 106396 130677 90391044
Aspartate aminotransferase increased 74.91 14.72 279 106447 102658 90419063
Amnesia 74.56 14.72 18 106708 108487 90413234
Pneumothorax 74.45 14.72 102 106624 19065 90502656
Musculoskeletal pain 74.02 14.72 56 106670 171195 90350526
Female genital tract fistula 73.84 14.72 98 106628 17770 90503951
Mastectomy 73.84 14.72 40 106686 2059 90519662
Hip arthroplasty 73.34 14.72 4 106722 76204 90445517
Meningitis aseptic 73.13 14.72 62 106664 6711 90515010
Gait disturbance 72.43 14.72 122 106604 260374 90261347
Duodenal perforation 71.98 14.72 32 106694 1066 90520655
Polymyalgia rheumatica 71.79 14.72 54 106672 4923 90516798
Encephalitis autoimmune 71.79 14.72 39 106687 2019 90519702
Haematotoxicity 69.98 14.72 80 106646 12455 90509266
Hyperhidrosis 69.29 14.72 37 106689 136268 90385453
Sarcoid-like reaction 68.87 14.72 20 106706 182 90521539
Ileus 68.76 14.72 91 106635 16455 90505266
Tumour haemorrhage 68.40 14.72 38 106688 2056 90519665
Cholecystitis acute 68.32 14.72 69 106657 9335 90512386
Lichen planus 68.30 14.72 42 106684 2749 90518972
Peripheral venous disease 68.30 14.72 9 106717 83912 90437809
Fluid retention 68.09 14.72 11 106715 88080 90433641
Suicidal ideation 67.72 14.72 5 106721 73850 90447871
Intentional product misuse 67.47 14.72 12 106714 89592 90432129
Pulmonary embolism 67.38 14.72 319 106407 130501 90391220
Infection 66.48 14.72 212 106514 361882 90159839
Autoimmune arthritis 65.67 14.72 16 106710 67 90521654
Chest pain 63.81 14.72 180 106546 319465 90202256
Liver injury 63.75 14.72 64 106662 170503 90351218
Physical deconditioning 63.44 14.72 37 106689 2198 90519523
Arthralgia 62.90 14.72 600 106126 777922 89743799
Asthenia 62.53 14.72 928 105798 532823 89988898
Therapeutic product effect incomplete 62.46 14.72 82 106644 193814 90327907
Influenza 62.18 14.72 44 106682 139220 90382501
Cytokine storm 61.91 14.72 24 106702 561 90521160
Ejection fraction decreased 61.83 14.72 111 106615 26142 90495579
Blood thyroid stimulating hormone abnormal 61.27 14.72 28 106698 996 90520725
Pulmonary sarcoidosis 60.82 14.72 30 106696 1269 90520452
Hepatitis cholestatic 60.71 14.72 62 106664 8499 90513222
Leukopenia 60.44 14.72 257 106469 100453 90421268
Eosinophilic fasciitis 60.38 14.72 18 106708 181 90521540
Septic shock 60.31 14.72 227 106499 83933 90437788
Hepatic enzyme increased 60.24 14.72 220 106506 360516 90161205
KL-6 increased 59.55 14.72 16 106710 106 90521615
Vascular access complication 58.26 14.72 36 106690 2377 90519344
Morphoea 57.73 14.72 21 106705 409 90521312
Pleural effusion 57.60 14.72 273 106453 111718 90410003
Prescribed underdose 56.59 14.72 10 106716 75009 90446712
Pulmonary fibrosis 56.40 14.72 28 106698 107475 90414246
Neck pain 56.38 14.72 32 106694 113931 90407790
Diabetes mellitus 55.96 14.72 186 106540 64689 90457032
Axillary lymphadenectomy 54.75 14.72 15 106711 108 90521613
Primary hypothyroidism 54.67 14.72 16 106710 150 90521571
Thrombophlebitis migrans 54.20 14.72 18 106708 264 90521457
Therapeutic response decreased 54.10 14.72 19 106707 89710 90432011
Microvascular coronary artery disease 53.95 14.72 18 106708 268 90521453
Immune-mediated cholestasis 53.39 14.72 12 106714 32 90521689
Polyarthritis 53.04 14.72 85 106641 18265 90503456
Pericardial effusion 52.84 14.72 127 106599 36706 90485015
Tumour necrosis 52.54 14.72 25 106701 976 90520745
Transitional cell carcinoma metastatic 52.16 14.72 10 106716 7 90521714
Joint stiffness 51.59 14.72 14 106712 78028 90443693
Sepsis 51.19 14.72 375 106351 179439 90342282
Autoimmune myocarditis 51.09 14.72 17 106709 251 90521470
Lymphadenectomy 50.97 14.72 26 106700 1182 90520539
Paraesthesia 50.66 14.72 140 106586 250186 90271535
Cancer pain 50.06 14.72 40 106686 3985 90517736
Altered state of consciousness 49.92 14.72 113 106613 31419 90490302
Eyelid ptosis 49.47 14.72 57 106669 8949 90512772
Lymphocytic hypophysitis 49.26 14.72 17 106709 282 90521439
Stress cardiomyopathy 48.77 14.72 69 106657 13286 90508435
Polyneuropathy in malignant disease 48.66 14.72 13 106713 84 90521637
Inflammation 48.38 14.72 85 106641 178507 90343214
Mixed liver injury 48.33 14.72 52 106674 7571 90514150
Off label use 47.96 14.72 1664 105062 1100588 89421133
Amylase increased 47.96 14.72 50 106676 7022 90514699
Feeling abnormal 46.76 14.72 78 106648 167157 90354564
Central venous catheterisation 46.46 14.72 33 106693 2753 90518968
Orbital myositis 46.26 14.72 12 106714 68 90521653
Stress 46.13 14.72 19 106707 81376 90440345
Disease progression 45.95 14.72 329 106397 156286 90365435
Gastrointestinal disorder 45.89 14.72 152 106574 256535 90265186
Autoimmune haemolytic anaemia 45.81 14.72 44 106682 5601 90516120
Pruritus 45.53 14.72 413 106313 541112 89980609
Wrong technique in product usage process 45.18 14.72 14 106712 71557 90450164
Ear pain 45.06 14.72 7 106719 57695 90464026
Uveitis 45.06 14.72 73 106653 15830 90505891
Pyelonephritis 45.02 14.72 86 106640 21230 90500491
Laryngitis 44.97 14.72 4 106722 50749 90470972
Nasal congestion 44.86 14.72 21 106705 83393 90438328
Hepatic failure 44.66 14.72 125 106601 39603 90482118
Multiple sclerosis relapse 44.06 14.72 5 106721 52300 90469421
Pancreatitis 43.30 14.72 180 106546 69646 90452075
Breast conserving surgery 42.85 14.72 23 106703 1162 90520559
Coma 42.74 14.72 16 106710 72616 90449105
Burning sensation 42.67 14.72 11 106715 63441 90458280
Onychomadesis 42.50 14.72 3 106723 45995 90475726
Vanishing bile duct syndrome 42.38 14.72 24 106702 1348 90520373
Peritonitis 42.23 14.72 80 106646 19625 90502096
Protein urine 41.77 14.72 20 106706 792 90520929
Hyponatraemia 41.20 14.72 284 106442 133254 90388467
Cortisol abnormal 41.19 14.72 11 106715 71 90521650
Adverse drug reaction 41.12 14.72 46 106680 116655 90405066
Autoimmune cholangitis 40.90 14.72 9 106717 21 90521700
Endocrine toxicity 40.83 14.72 10 106716 43 90521678
Cortisol increased 40.56 14.72 17 106709 489 90521232
Psoriasis 40.31 14.72 70 106656 147684 90374037
Thyroxine free increased 40.15 14.72 21 106705 1006 90520715
Myelitis transverse 40.09 14.72 24 106702 1496 90520225
Ill-defined disorder 39.99 14.72 100 106626 184791 90336930
Osteoporosis 39.89 14.72 33 106693 96498 90425223
Melanoma recurrent 39.44 14.72 13 106713 186 90521535
Hydronephrosis 39.39 14.72 60 106666 12342 90509379
Cell death 39.37 14.72 31 106695 3024 90518697
Abdominal distension 39.28 14.72 58 106668 130543 90391178
Ketoacidosis 38.73 14.72 40 106686 5555 90516166
Gastroenteritis radiation 38.41 14.72 17 106709 560 90521161
Malignant ascites 38.36 14.72 20 106706 952 90520769
Autoimmune retinopathy 38.26 14.72 8 106718 13 90521708
Myalgia 37.81 14.72 343 106383 174782 90346939
Haemolytic anaemia 37.74 14.72 57 106669 11640 90510081
Lactic acidosis 37.47 14.72 7 106719 50456 90471265
Toxicity to various agents 37.37 14.72 193 106533 287653 90234068
Autoimmune lung disease 37.32 14.72 11 106715 106 90521615
Swelling face 37.24 14.72 25 106701 81327 90440394
Pain in jaw 37.06 14.72 6 106720 47979 90473742
Foetal exposure during pregnancy 36.47 14.72 4 106722 42971 90478750
Troponin T increased 36.13 14.72 23 106703 1600 90520121
Back pain 36.12 14.72 222 106504 316953 90204768
Medical device site thrombosis 36.03 14.72 10 106716 76 90521645
Cervix cancer metastatic 35.91 14.72 10 106716 77 90521644
Radiation necrosis 35.91 14.72 17 106709 656 90521065
Metastases to meninges 35.91 14.72 32 106694 3703 90518018
Pericarditis malignant 35.89 14.72 7 106719 6 90521715
Cervix carcinoma recurrent 35.83 14.72 12 106714 181 90521540
Hyperthermia 35.69 14.72 52 106674 10283 90511438
Papilloedema 35.63 14.72 35 106691 4580 90517141
Hospice care 35.23 14.72 50 106676 9654 90512067
Prerenal failure 35.15 14.72 25 106701 2090 90519631
Thyroiditis subacute 34.76 14.72 14 106712 363 90521358
Endocarditis noninfective 34.74 14.72 10 106716 88 90521633
Ulcerative duodenitis 34.47 14.72 6 106720 0 90521721
International normalised ratio increased 34.21 14.72 7 106719 47309 90474412
Hepatic cirrhosis 33.90 14.72 16 106710 63237 90458484
BRCA1 gene mutation 33.85 14.72 9 106717 57 90521664
Thrombotic microangiopathy 33.84 14.72 64 106662 15679 90506042
N-terminal prohormone brain natriuretic peptide increased 33.81 14.72 28 106698 2934 90518787
Malignant pleural effusion 33.79 14.72 28 106698 2936 90518785
Macular degeneration 33.62 14.72 3 106723 37967 90483754
Postrenal failure 33.41 14.72 12 106714 225 90521496
Sedation 33.07 14.72 8 106718 48163 90473558
Enteritis 32.88 14.72 50 106676 10271 90511450
Metastases to adrenals 32.64 14.72 18 106708 960 90520761
Unevaluable event 32.41 14.72 12 106714 54836 90466885
Anti-glomerular basement membrane disease 32.36 14.72 9 106717 69 90521652
Aspartate aminotransferase abnormal 32.25 14.72 26 106700 2623 90519098
Positron emission tomogram abnormal 32.24 14.72 13 106713 338 90521383
Renal arteriosclerosis 32.24 14.72 11 106715 176 90521545
Recurrent cancer 31.79 14.72 25 106701 2434 90519287
Cancer fatigue 31.68 14.72 11 106715 186 90521535
Malignant gastrointestinal obstruction 31.68 14.72 8 106718 40 90521681
Gastric perforation 31.66 14.72 23 106703 1988 90519733
Coeliac disease 31.44 14.72 7 106719 44603 90477118
Cardiac failure acute 31.43 14.72 53 106673 11876 90509845
Scleroedema 31.22 14.72 10 106716 130 90521591
Frequent bowel movements 31.13 14.72 14 106712 56921 90464800
Renal tubular injury 31.09 14.72 19 106707 1230 90520491
Lung adenocarcinoma recurrent 31.08 14.72 9 106717 81 90521640
Intestinal obstruction 30.73 14.72 105 106621 37026 90484695
Bradycardia 30.71 14.72 32 106694 83815 90437906
Acquired gene mutation 30.67 14.72 19 106707 1260 90520461
Feeling hot 30.62 14.72 28 106698 77980 90443741
Drug effective for unapproved indication 30.54 14.72 42 106684 7876 90513845
Immune-mediated encephalopathy 30.54 14.72 7 106719 21 90521700
Metastases to central nervous system 30.18 14.72 65 106661 17477 90504244
Somnolence 30.15 14.72 135 106591 208949 90312772
Rash morbilliform 30.07 14.72 30 106696 3999 90517722
Lupus-like syndrome 30.04 14.72 10 106716 48836 90472885
Agranulocytosis 29.86 14.72 100 106626 34902 90486819
Bicytopenia 29.86 14.72 29 106697 3742 90517979
Rhinorrhoea 29.83 14.72 36 106690 88280 90433441
Gamma-glutamyltransferase abnormal 29.75 14.72 14 106712 533 90521188
Plasma cell myeloma 29.60 14.72 6 106720 40822 90480899
Hepatitis acute 29.52 14.72 49 106677 10838 90510883
Heart rate increased 29.44 14.72 55 106671 112847 90408874
Pancreatic haemorrhage 29.19 14.72 7 106719 27 90521694
Visual impairment 29.08 14.72 71 106655 132294 90389427
Oedema 29.08 14.72 129 106597 200166 90321555
Breast cancer recurrent 28.84 14.72 34 106692 5469 90516252
Roseolovirus test positive 28.75 14.72 9 106717 108 90521613
Irritability 28.60 14.72 4 106722 35658 90486063
Tremor 28.55 14.72 89 106637 153084 90368637
Respiratory arrest 28.52 14.72 3 106723 33308 90488413
Laryngopharyngitis 28.46 14.72 8 106718 64 90521657
Diastolic dysfunction 28.44 14.72 39 106687 7294 90514427
Lymphangiosis carcinomatosa 28.34 14.72 20 106706 1652 90520069
Cardiac tamponade 28.21 14.72 34 106692 5598 90516123
Duodenitis 28.08 14.72 30 106696 4333 90517388
Dermatitis 28.07 14.72 73 106653 22147 90499574
Transaminases increased 28.04 14.72 102 106624 37090 90484631
Epistaxis 28.03 14.72 184 106542 84941 90436780
Palpitations 27.99 14.72 76 106650 136652 90385069
Neonatal respiratory depression 27.92 14.72 10 106716 186 90521535
Cardiac imaging procedure abnormal 27.90 14.72 6 106720 12 90521709
Necrotic lymphadenopathy 27.68 14.72 9 106717 123 90521598
Cardiogenic shock 27.51 14.72 77 106649 24391 90497330
Paraneoplastic neurological syndrome 27.24 14.72 7 106719 38 90521683
Nephrolithiasis 26.95 14.72 12 106714 49073 90472648
Incorrect route of product administration 26.83 14.72 13 106713 50613 90471108
Hyperamylasaemia 26.73 14.72 13 106713 533 90521188
Thyroid hormones decreased 26.69 14.72 14 106712 675 90521046
Brain natriuretic peptide increased 26.46 14.72 34 106692 5971 90515750
Pneumonia 26.34 14.72 562 106164 637497 89884224
Autoimmune disorder 26.22 14.72 31 106695 76713 90445008
Blood corticotrophin abnormal 26.18 14.72 6 106720 18 90521703
Blood lactate dehydrogenase abnormal 26.07 14.72 12 106714 434 90521287
Cardiac failure congestive 25.80 14.72 48 106678 98646 90423075
Purpura 25.70 14.72 55 106671 14723 90506998
Cutaneous sarcoidosis 25.59 14.72 12 106714 453 90521268
Peripheral sensory neuropathy 25.58 14.72 42 106684 9208 90512513
Eye pain 25.53 14.72 10 106716 44158 90477563
Hallucination 25.50 14.72 24 106702 65935 90455786
Polyglandular autoimmune syndrome type II 25.48 14.72 7 106719 51 90521670
Protein urine present 25.38 14.72 36 106690 6948 90514773
Bile duct stenosis 25.35 14.72 19 106707 1723 90519998
Hyperglycaemia 25.29 14.72 123 106603 50847 90470874
Cholangitis acute 25.20 14.72 13 106713 605 90521116
Perforation 25.19 14.72 20 106706 1974 90519747
Dysaesthesia 25.14 14.72 31 106695 5224 90516497
Pulmonary artery thrombosis 25.07 14.72 14 106712 765 90520956
Cardiac ventricular thrombosis 25.07 14.72 16 106710 1118 90520603
Influenza like illness 25.02 14.72 35 106691 80576 90441145
Neutrophil toxic granulation present 25.00 14.72 9 106717 170 90521551
Gastrointestinal toxicity 24.86 14.72 42 106684 9425 90512296
Gastritis haemorrhagic 24.79 14.72 19 106707 1781 90519940
Hepatitis toxic 24.66 14.72 26 106700 3699 90518022
Eye irritation 24.62 14.72 5 106721 33973 90487748
Gallbladder enlargement 24.58 14.72 15 106711 968 90520753
Maternal exposure via partner during pregnancy 24.36 14.72 5 106721 7 90521714
Paraneoplastic syndrome 24.33 14.72 13 106713 651 90521070
Pneumocystis jirovecii pneumonia 24.28 14.72 68 106658 21548 90500173
Metastatic malignant melanoma 24.27 14.72 18 106708 1606 90520115
Cutaneous symptom 24.25 14.72 12 106714 511 90521210
Hyperlipasaemia 24.23 14.72 14 106712 817 90520904
Oedema peripheral 24.19 14.72 191 106535 257724 90263997
Ureteritis 24.17 14.72 8 106718 116 90521605
Periarticular thenar erythema with onycholysis 24.17 14.72 7 106719 63 90521658
Hepatocellular injury 24.06 14.72 82 106644 28876 90492845
Gastric disorder 24.01 14.72 5 106721 33379 90488342
Pneumonia bacterial 23.87 14.72 49 106677 12741 90508980
Neoplasm recurrence 23.84 14.72 24 106702 3235 90518486
Heart rate decreased 23.75 14.72 17 106709 53488 90468233
Feeding disorder 23.65 14.72 59 106667 17453 90504268
Amputation stump pain 23.59 14.72 6 106720 31 90521690
Renal cell carcinoma recurrent 23.59 14.72 5 106721 9 90521712
Inappropriate antidiuretic hormone secretion 23.54 14.72 63 106663 19442 90502279
Glomerulonephritis 23.42 14.72 21 106705 2449 90519272
Fistula 23.38 14.72 47 106679 12042 90509679
Keratitis 23.10 14.72 26 106700 3980 90517741
Ophthalmoplegia 23.08 14.72 18 106708 1731 90519990
Autoimmune endocrine disorder 22.98 14.72 4 106722 0 90521721
Pulmonary imaging procedure abnormal 22.92 14.72 5 106721 11 90521710
Nephritis allergic 22.87 14.72 10 106716 320 90521401
Femur fracture 22.70 14.72 13 106713 46069 90475652
Cataract 22.68 14.72 31 106695 72061 90449660
Multiple organ dysfunction syndrome 22.67 14.72 148 106578 68188 90453533
Swollen tongue 22.59 14.72 13 106713 45943 90475778
Lung lobectomy 22.53 14.72 8 106718 145 90521576
Necrosis 22.45 14.72 33 106693 6577 90515144
Solid organ transplant rejection 22.43 14.72 6 106720 39 90521682
Vesical fistula 22.43 14.72 8 106718 147 90521574
Gastrointestinal oedema 22.41 14.72 17 106709 1569 90520152
Coronavirus infection 22.40 14.72 30 106696 5485 90516236
Myocardial infarction 22.38 14.72 58 106668 105914 90415807
Bladder tamponade 22.38 14.72 8 106718 148 90521573
Respiratory disorder 22.34 14.72 26 106700 64790 90456931
Pulmonary radiation injury 22.34 14.72 5 106721 13 90521708
Tumour lysis syndrome 22.34 14.72 44 106682 11108 90510613
EGFR gene mutation 22.30 14.72 10 106716 340 90521381
Blood pressure abnormal 22.26 14.72 62 106664 19583 90502138
Balance disorder 22.18 14.72 51 106675 97029 90424692
Device issue 22.14 14.72 4 106722 29533 90492188
Blood creatinine increased 22.09 14.72 199 106527 101187 90420534
Autoimmune dermatitis 22.08 14.72 8 106718 154 90521567
Henoch-Schonlein purpura 22.03 14.72 17 106709 1610 90520111
Chronic obstructive pulmonary disease 21.99 14.72 33 106693 73796 90447925
Agitation 21.98 14.72 28 106698 67070 90454651
Thyroxine increased 21.88 14.72 13 106713 799 90520922
Mixed deafness 21.81 14.72 5 106721 15 90521706
Loss of consciousness 21.78 14.72 88 106638 140150 90381571
Inflammatory marker increased 21.75 14.72 39 106687 9175 90512546
Organising pneumonia 21.69 14.72 35 106691 7562 90514159
Emotional distress 21.69 14.72 8 106718 36654 90485067
Optic neuritis 21.62 14.72 40 106686 9638 90512083
Immunodeficiency 21.58 14.72 12 106714 43222 90478499
Breast tumour excision 21.57 14.72 5 106721 16 90521705
Productive cough 21.48 14.72 36 106690 77027 90444694
Breast cancer 21.45 14.72 19 106707 53742 90467979
Mucosal disorder 21.36 14.72 21 106705 2750 90518971
Thyroxine free decreased 21.36 14.72 13 106713 835 90520886
Angioedema 21.33 14.72 27 106699 64849 90456872
Joint injury 21.32 14.72 6 106720 32658 90489063
Lipase increased 21.25 14.72 43 106683 11068 90510653
Idiopathic interstitial pneumonia 21.25 14.72 9 106717 266 90521455
Coombs negative haemolytic anaemia 21.19 14.72 10 106716 383 90521338
Pulmonary necrosis 21.17 14.72 8 106718 174 90521547
Ventricular dysfunction 21.15 14.72 24 106702 3707 90518014
Nail disorder 21.12 14.72 23 106703 59044 90462677
Product administration error 21.10 14.72 3 106723 26420 90495301
Vascular purpura 21.04 14.72 17 106709 1721 90520000
Tri-iodothyronine free decreased 20.95 14.72 10 106716 393 90521328
Benign mediastinal neoplasm 20.92 14.72 6 106720 52 90521669
Tracheal stenosis 20.91 14.72 9 106717 277 90521444
Lymph node fibrosis 20.91 14.72 5 106721 19 90521702
Bone marrow failure 20.71 14.72 84 106642 32137 90489584
Vogt-Koyanagi-Harada disease 20.70 14.72 10 106716 404 90521317
Limbic encephalitis 20.64 14.72 9 106717 286 90521435
Mediastinal cyst 20.53 14.72 6 106720 56 90521665
Hypermetabolism 20.46 14.72 9 106717 292 90521429
Neurofibrosarcoma 20.44 14.72 8 106718 192 90521529
Carcinoembryonic antigen increased 20.37 14.72 19 106707 2331 90519390
Acute myeloid leukaemia 20.37 14.72 62 106664 20578 90501143
Rash 20.25 14.72 1138 105588 794962 89726759
Chest discomfort 20.14 14.72 89 106637 138276 90383445
Hospitalisation 20.13 14.72 80 106646 128020 90393701
Syncope 20.13 14.72 84 106642 132579 90389142
Thyroid hormones increased 20.08 14.72 11 106715 579 90521142
Full blood count abnormal 20.01 14.72 9 106717 36588 90485133
Dyskinesia 19.95 14.72 9 106717 36525 90485196
Eye swelling 19.94 14.72 5 106721 29381 90492340
Hypermutation 19.81 14.72 6 106720 64 90521657
Treatment noncompliance 19.79 14.72 19 106707 51708 90470013
Throat irritation 19.68 14.72 17 106709 48678 90473043
Hepatic cyst infection 19.60 14.72 7 106719 129 90521592
Skin reaction 19.51 14.72 57 106669 18496 90503225
Autoimmune anaemia 19.32 14.72 4 106722 6 90521715
Rectal haemorrhage 19.28 14.72 43 106683 82701 90439020
Endocarditis 19.27 14.72 32 106694 7081 90514640
Sopor 19.22 14.72 3 106723 24641 90497080
Cancer surgery 19.16 14.72 11 106715 634 90521087
Cerebral haemorrhage 19.10 14.72 86 106640 34436 90487285
Arthritis 19.08 14.72 117 106609 167198 90354523
Scleroderma-like reaction 19.07 14.72 7 106719 140 90521581
Polyneuropathy 19.00 14.72 58 106668 19283 90502438
Paraneoplastic dermatomyositis 18.98 14.72 7 106719 142 90521579
Hypereosinophilic syndrome 18.92 14.72 9 106717 351 90521370
Radiation associated pain 18.90 14.72 8 106718 236 90521485
Neutrophil percentage abnormal 18.89 14.72 5 106721 31 90521690
Heart rate irregular 18.82 14.72 3 106723 24265 90497456
Rash pruritic 18.75 14.72 163 106563 82051 90439670
Melanosis 18.63 14.72 5 106721 33 90521688
Ischaemic stroke 18.62 14.72 63 106663 22103 90499618
HTLV-1 test positive 18.60 14.72 4 106722 8 90521713
Acute motor-sensory axonal neuropathy 18.57 14.72 9 106717 366 90521355
Lymphocyte percentage abnormal 18.50 14.72 5 106721 34 90521687
Encephalomyelitis 18.37 14.72 7 106719 156 90521565
Procalcitonin increased 18.30 14.72 15 106711 1549 90520172
Radiotherapy to lymph nodes 18.28 14.72 4 106722 9 90521712
Upper gastrointestinal perforation 18.25 14.72 5 106721 36 90521685
SJS-TEN overlap 18.19 14.72 13 106713 1095 90520626
Monocyte count abnormal 18.12 14.72 8 106718 262 90521459
Back disorder 18.10 14.72 4 106722 25627 90496094
Dermatitis atopic 17.98 14.72 3 106723 23469 90498252
Hyperpyrexia 17.98 14.72 25 106701 4736 90516985
Haematoma 17.87 14.72 12 106714 39036 90482685
Shock symptom 17.81 14.72 8 106718 273 90521448
Capillary leak syndrome 17.76 14.72 19 106707 2748 90518973
Intervertebral disc protrusion 17.74 14.72 5 106721 27191 90494530
Hypomagnesaemia 17.74 14.72 86 106640 35502 90486219
Bronchogram abnormal 17.71 14.72 4 106722 11 90521710
Pyoderma gangrenosum 17.70 14.72 24 106702 4440 90517281
Encephalitis toxic 17.68 14.72 5 106721 41 90521680
Pneumatosis intestinalis 17.62 14.72 21 106705 3416 90518305
Atrioventricular block complete 17.62 14.72 37 106689 9774 90511947
Nephrosclerosis 17.57 14.72 13 106713 1156 90520565
Blood creatine phosphokinase increased 17.52 14.72 83 106643 33940 90487781
Aortic embolus 17.47 14.72 5 106721 43 90521678
Therapy interrupted 17.38 14.72 20 106706 50088 90471633
Aortic rupture 17.36 14.72 6 106720 100 90521621
Gastroenteritis viral 17.34 14.72 7 106719 30348 90491373
Hand dermatitis 17.33 14.72 10 106716 582 90521139
Lung opacity 17.27 14.72 28 106698 6074 90515647
Urethral stent insertion 17.24 14.72 3 106723 0 90521721
Monocyte percentage abnormal 17.24 14.72 3 106723 0 90521721
Squamous cell carcinoma antigen increased 17.24 14.72 3 106723 0 90521721
Allergic bronchopulmonary mycosis 17.24 14.72 3 106723 0 90521721
Oedematous pancreatitis 17.17 14.72 11 106715 774 90520947
Endometrial cancer recurrent 17.07 14.72 5 106721 47 90521674
Tumour cavitation 17.07 14.72 5 106721 47 90521674
IIIrd nerve disorder 16.98 14.72 4 106722 14 90521707
Myocarditis infectious 16.98 14.72 5 106721 48 90521673
Oligodipsia 16.98 14.72 5 106721 48 90521673
Lymphadenopathy 16.97 14.72 102 106624 45673 90476048
Urine protein/creatinine ratio increased 16.91 14.72 12 106714 1000 90520721
Hypokalaemia 16.89 14.72 232 106494 130884 90390837
Hip fracture 16.77 14.72 9 106717 33068 90488653
Acute interstitial pneumonitis 16.74 14.72 11 106715 808 90520913
Respiratory failure 16.70 14.72 213 106513 118205 90403516
Eyelid sensory disorder 16.63 14.72 6 106720 114 90521607
Amaurosis 16.61 14.72 11 106715 819 90520902
Pneumonia moraxella 16.54 14.72 5 106721 53 90521668
Acute coronary syndrome 16.28 14.72 38 106688 10775 90510946
Aortic thrombosis 16.23 14.72 13 106713 1299 90520422
Oropharyngeal pain 16.22 14.72 75 106651 115112 90406609
Antinuclear antibody 16.05 14.72 9 106717 496 90521225
Systemic scleroderma 16.05 14.72 14 106712 1575 90520146
Autoimmune uveitis 16.01 14.72 4 106722 19 90521702
Metastases to peritoneum 15.97 14.72 22 106704 4133 90517588
Enterovesical fistula 15.96 14.72 10 106716 677 90521044
AST/ALT ratio abnormal 15.94 14.72 6 106720 129 90521592
Ureteric dilatation 15.90 14.72 5 106721 61 90521660
Vascular access site complication 15.84 14.72 4 106722 20 90521701
Skin haemorrhage 15.80 14.72 3 106723 21377 90500344
Tri-iodothyronine decreased 15.78 14.72 7 106719 232 90521489
Blood alkaline phosphatase abnormal 15.76 14.72 13 106713 1355 90520366
Metastases to lung 15.75 14.72 48 106678 15943 90505778
Oxygen saturation decreased 15.73 14.72 69 106657 107414 90414307
Psoas abscess 15.68 14.72 10 106716 698 90521023
Interleukin-2 receptor increased 15.57 14.72 6 106720 138 90521583
Pseudocellulitis 15.53 14.72 6 106720 139 90521582
Autoimmune thyroid disorder 15.52 14.72 4 106722 22 90521699
Alanine aminotransferase abnormal 15.50 14.72 25 106701 5401 90516320
Miller Fisher syndrome 15.45 14.72 6 106720 141 90521580
Haemoglobin abnormal 15.43 14.72 29 106697 7071 90514650
Extremity necrosis 15.40 14.72 15 106711 1942 90519779
Accidental overdose 15.38 14.72 7 106719 28266 90493455
Gastrointestinal fistula 15.35 14.72 9 106717 540 90521181
Portal venous gas 15.34 14.72 5 106721 69 90521652
Peripheral motor neuropathy 15.30 14.72 15 106711 1958 90519763
Small intestinal haemorrhage 15.30 14.72 16 106710 2255 90519466
Delirium 15.27 14.72 67 106659 104292 90417429
Carbohydrate antigen 125 increased 15.20 14.72 19 106707 3247 90518474
Embolism venous 15.18 14.72 20 106706 3600 90518121
Full blood count decreased 15.17 14.72 8 106718 29681 90492040
Radiotherapy to brain 15.16 14.72 3 106723 3 90521718
Glaucoma 15.15 14.72 3 106723 20752 90500969
CSF volume increased 15.09 14.72 4 106722 25 90521696
Restlessness 15.02 14.72 12 106714 35708 90486013
Illness 15.01 14.72 48 106678 81921 90439800
Duodenal ulcer 14.86 14.72 34 106692 9518 90512203
Pancreatic failure 14.78 14.72 13 106713 1479 90520242
Myxoedema 14.74 14.72 6 106720 160 90521561
Flushing 14.72 14.72 54 106672 88437 90433284

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 6893.02 13.22 3807 94011 104593 42418924
Immune-mediated hepatic disorder 1565.37 13.22 461 97357 2053 42521464
Therapy partial responder 1337.17 13.22 730 97088 19291 42504226
Interstitial lung disease 1246.24 13.22 1192 96626 77270 42446247
Immune-mediated adverse reaction 1158.48 13.22 298 97520 690 42522827
Immune-mediated enterocolitis 1136.70 13.22 444 97374 5233 42518284
Immune-mediated myocarditis 1081.73 13.22 334 97484 1800 42521717
Immune-mediated lung disease 1005.09 13.22 356 97462 3117 42520400
Hypothyroidism 958.81 13.22 703 97115 31381 42492136
Pneumonitis 929.12 13.22 768 97050 40950 42482567
Adrenal insufficiency 850.58 13.22 534 97284 18390 42505127
Tumour pseudoprogression 695.22 13.22 202 97616 848 42522669
Immune-mediated hepatitis 681.48 13.22 274 97544 3500 42520017
Immune-mediated hypothyroidism 618.74 13.22 193 97625 1081 42522436
Myocarditis 554.29 13.22 410 97408 18528 42504989
Colitis 546.70 13.22 602 97216 45970 42477547
Immune-mediated renal disorder 502.87 13.22 132 97686 341 42523176
Type 1 diabetes mellitus 501.01 13.22 247 97571 5240 42518277
Immune-mediated dermatitis 481.01 13.22 159 97659 1102 42522415
Immune-mediated myositis 457.85 13.22 207 97611 3586 42519931
Product use in unapproved indication 427.32 13.22 1152 96666 183304 42340213
Product use issue 421.41 13.22 684 97134 76067 42447450
Immune-mediated adrenal insuficiency 404.06 13.22 123 97695 626 42522891
Palmar-plantar erythrodysaesthesia syndrome 400.68 13.22 351 97467 20231 42503286
Proteinuria 357.99 13.22 346 97472 22637 42500880
Tubulointerstitial nephritis 346.40 13.22 394 97424 31154 42492363
Myositis 339.61 13.22 278 97540 14588 42508929
Adrenocorticotropic hormone deficiency 334.88 13.22 124 97694 1246 42522271
Pulmonary toxicity 321.91 13.22 217 97601 8438 42515079
Hepatic function abnormal 294.40 13.22 468 97350 51099 42472418
Immune-mediated arthritis 292.08 13.22 79 97739 238 42523279
Myelosuppression 287.80 13.22 407 97411 40054 42483463
Decreased appetite 285.19 13.22 1032 96786 192105 42331412
Drug interaction 279.32 13.22 132 97686 266867 42256650
Renal impairment 276.74 13.22 710 97108 109518 42413999
Nephritis 260.60 13.22 141 97677 3648 42519869
Thyroiditis 255.36 13.22 132 97686 3104 42520413
Eastern Cooperative Oncology Group performance status worsened 255.08 13.22 101 97717 1235 42522282
Hypophysitis 252.62 13.22 128 97690 2883 42520634
Death 247.19 13.22 1885 95933 469300 42054217
Hepatitis 237.51 13.22 303 97515 26997 42496520
Immune-mediated thyroiditis 235.64 13.22 74 97744 425 42523092
Pemphigoid 232.09 13.22 200 97618 11267 42512250
Immune-mediated pancreatitis 229.64 13.22 66 97752 264 42523253
Hyperthyroidism 214.11 13.22 211 97607 14130 42509387
Cholangitis 212.87 13.22 185 97633 10542 42512975
Myasthenia gravis 202.10 13.22 216 97602 15921 42507596
Neuropathy peripheral 201.93 13.22 602 97216 101251 42422266
Tumour hyperprogression 199.58 13.22 52 97766 129 42523388
Autoimmune hepatitis 196.79 13.22 136 97682 5509 42518008
Fall 189.79 13.22 156 97662 234364 42289153
Immune-mediated nephritis 188.79 13.22 69 97749 666 42522851
Neoplasm progression 187.64 13.22 279 97539 28721 42494796
Immune-mediated encephalitis 185.93 13.22 66 97752 581 42522936
Toxic epidermal necrolysis 184.15 13.22 265 97553 26485 42497032
Lichenoid keratosis 183.74 13.22 114 97704 3836 42519681
Completed suicide 180.65 13.22 10 97808 96455 42427062
Immune-mediated cholangitis 179.16 13.22 61 97757 468 42523049
Hepatic cytolysis 173.30 13.22 258 97560 26586 42496931
Radiotherapy 168.85 13.22 67 97751 824 42522693
Overdose 167.12 13.22 22 97796 105242 42418275
Immune-mediated hypophysitis 165.00 13.22 54 97764 361 42523156
Hypertension 162.13 13.22 786 97032 166418 42357099
Skin disorder 158.42 13.22 195 97623 16749 42506768
Skin toxicity 154.87 13.22 125 97693 6424 42517093
Stevens-Johnson syndrome 151.61 13.22 219 97599 21959 42501558
Taste disorder 148.33 13.22 148 97670 10059 42513458
Dizziness 148.29 13.22 214 97604 249040 42274477
Rash 146.18 13.22 1111 96707 275843 42247674
Immune-mediated gastritis 145.22 13.22 37 97781 81 42523436
Headache 144.88 13.22 203 97615 239166 42284351
Dysphonia 141.80 13.22 243 97575 28207 42495310
Vitiligo 137.95 13.22 64 97754 1179 42522338
Cholangitis sclerosing 134.21 13.22 72 97746 1830 42521687
Haemophagocytic lymphohistiocytosis 133.51 13.22 186 97632 18036 42505481
Diabetic ketoacidosis 133.09 13.22 207 97611 22160 42501357
Autoimmune hypothyroidism 131.24 13.22 38 97780 157 42523360
Stomatitis 130.07 13.22 328 97490 50001 42473516
Adverse event 128.60 13.22 210 97608 23430 42500087
Diarrhoea 128.28 13.22 1616 96202 459233 42064284
Autoimmune colitis 127.41 13.22 59 97759 1082 42522435
Pancytopenia 125.37 13.22 569 97249 117174 42406343
Toxicity to various agents 121.79 13.22 212 97606 228924 42294593
Anxiety 118.63 13.22 62 97756 118498 42405019
Hypertransaminasaemia 118.16 13.22 125 97693 9102 42514415
Inappropriate schedule of product administration 117.85 13.22 484 97334 95418 42428099
Intentional product misuse 114.08 13.22 7 97811 61893 42461624
Hypopituitarism 113.50 13.22 74 97744 2717 42520800
Depression 111.76 13.22 58 97760 111305 42412212
Injection site pain 111.34 13.22 5 97813 57793 42465724
Myasthenic syndrome 109.30 13.22 48 97770 773 42522744
Pseudocellulitis 109.20 13.22 36 97782 247 42523270
Product dose omission issue 109.05 13.22 116 97702 154249 42369268
Insomnia 108.11 13.22 69 97749 118184 42405333
Drug eruption 105.78 13.22 190 97628 22885 42500632
Encephalitis 103.22 13.22 116 97702 9042 42514475
Polymyalgia rheumatica 102.90 13.22 65 97753 2258 42521259
Drug hypersensitivity 102.38 13.22 50 97768 99339 42424178
Hypothalamo-pituitary disorder 101.83 13.22 50 97768 1050 42522467
Secondary adrenocortical insufficiency 101.24 13.22 62 97756 2037 42521480
Somnolence 99.70 13.22 106 97712 140999 42382518
Pain in extremity 96.85 13.22 122 97696 150482 42373035
Thyroid disorder 96.82 13.22 77 97741 3873 42519644
Nasopharyngitis 96.49 13.22 36 97782 83960 42439557
Condition aggravated 93.83 13.22 297 97521 260457 42263060
Hepatotoxicity 92.90 13.22 189 97629 24978 42498539
Adrenal disorder 91.77 13.22 48 97770 1157 42522360
Immune-mediated neuropathy 90.60 13.22 24 97794 65 42523452
Agitation 89.74 13.22 19 97799 64295 42459222
Suicidal ideation 87.11 13.22 6 97812 48155 42475362
Immune thrombocytopenia 84.42 13.22 116 97702 11100 42512417
Eosinophilic fasciitis 84.18 13.22 25 97793 115 42523402
KL-6 increased 84.01 13.22 25 97793 116 42523401
Tremor 83.97 13.22 60 97758 96869 42426648
Immune-mediated hyperthyroidism 83.60 13.22 28 97790 203 42523314
Fulminant type 1 diabetes mellitus 83.14 13.22 47 97771 1327 42522190
Muscle spasms 83.12 13.22 47 97771 85997 42437520
Plasma cell myeloma 83.02 13.22 7 97811 47571 42475946
Blood thyroid stimulating hormone increased 82.98 13.22 80 97738 5212 42518305
Cardiac failure congestive 82.35 13.22 47 97771 85555 42437962
Hypotension 82.16 13.22 309 97509 257322 42266195
Lung lobectomy 82.16 13.22 22 97796 63 42523454
Bradycardia 82.14 13.22 47 97771 85437 42438080
Aggression 81.36 13.22 5 97813 44158 42479359
Hyperhidrosis 79.76 13.22 55 97763 90457 42433060
Pain 78.50 13.22 293 97525 244555 42278962
Eyelid ptosis 77.86 13.22 86 97732 6575 42516942
Encephalitis autoimmune 77.69 13.22 45 97773 1332 42522185
Immune-mediated neurological disorder 77.11 13.22 18 97800 22 42523495
Immune-mediated endocrinopathy 75.55 13.22 20 97798 54 42523463
Rash maculo-papular 75.46 13.22 223 97595 37280 42486237
Intentional product use issue 74.17 13.22 36 97782 71797 42451720
Stress 73.19 13.22 8 97810 44204 42479313
Pneumonia bacterial 72.93 13.22 130 97688 15562 42507955
Asthma 72.76 13.22 26 97792 62288 42461229
Immune-mediated cytopenia 72.76 13.22 24 97794 165 42523352
Abdominal distension 72.48 13.22 37 97781 71698 42451819
Neutrophil count decreased 72.36 13.22 313 97505 63102 42460415
Drug ineffective 71.06 13.22 1020 96798 629177 41894340
Lichen planus 70.11 13.22 41 97777 1236 42522281
Syncope 69.83 13.22 75 97743 99331 42424186
International normalised ratio increased 69.77 13.22 13 97805 48155 42475362
Musculoskeletal stiffness 69.35 13.22 23 97795 57742 42465775
Loss of personal independence in daily activities 68.92 13.22 15 97803 49801 42473716
Hallucination 68.86 13.22 23 97795 57484 42466033
Joint swelling 68.86 13.22 35 97783 67987 42455530
Tumour haemorrhage 68.67 13.22 61 97757 3577 42519940
Blood corticotrophin decreased 68.44 13.22 26 97792 282 42523235
Thrombophlebitis migrans 67.26 13.22 27 97791 343 42523174
Cortisol decreased 67.22 13.22 41 97777 1337 42522180
Unevaluable event 65.92 13.22 3 97815 34285 42489232
Electrocardiogram QT prolonged 65.19 13.22 15 97803 47930 42475587
Hypersensitivity 63.72 13.22 44 97774 72326 42451191
Radiation pneumonitis 63.11 13.22 53 97765 2880 42520637
Autoimmune lung disease 63.02 13.22 18 97800 70 42523447
Confusional state 62.98 13.22 187 97631 167410 42356107
Haemoglobin decreased 62.05 13.22 132 97686 132339 42391178
Liver disorder 61.82 13.22 216 97602 39428 42484089
Seizure 60.86 13.22 115 97703 120446 42403071
Wheezing 60.40 13.22 25 97793 54756 42468761
Autoimmune myocarditis 60.34 13.22 23 97795 252 42523265
Subacute cutaneous lupus erythematosus 59.40 13.22 39 97779 1449 42522068
Transitional cell carcinoma metastatic 59.22 13.22 18 97800 91 42523426
Swelling 58.99 13.22 26 97792 54859 42468658
Nephrectomy 57.53 13.22 32 97786 875 42522642
Pericarditis malignant 56.90 13.22 16 97802 58 42523459
Pulmonary ossification 56.69 13.22 16 97802 59 42523458
Lactic acidosis 56.15 13.22 17 97801 45244 42478273
Chest pain 55.86 13.22 151 97667 139379 42384138
Coma 55.04 13.22 27 97791 53527 42469990
Gastrointestinal anastomotic leak 54.77 13.22 27 97791 572 42522945
Wrong technique in product usage process 54.75 13.22 15 97803 42620 42480897
Colitis microscopic 54.16 13.22 50 97768 3083 42520434
Immune-mediated cystitis 53.29 13.22 16 97802 77 42523440
Loss of consciousness 53.13 13.22 81 97737 92273 42431244
Immune-mediated encephalopathy 52.59 13.22 15 97803 58 42523459
Medication error 52.41 13.22 7 97811 33147 42490370
Organising pneumonia 52.37 13.22 75 97743 7457 42516060
Adrenocortical insufficiency acute 51.78 13.22 42 97776 2173 42521344
Blood thyroid stimulating hormone abnormal 51.68 13.22 23 97795 383 42523134
Immune-mediated uveitis 51.64 13.22 17 97801 116 42523401
Vascular access complication 51.62 13.22 23 97795 384 42523133
Prostate cancer 51.48 13.22 19 97799 44624 42478893
Dermatitis psoriasiform 51.23 13.22 41 97777 2081 42521436
Meningitis aseptic 50.90 13.22 57 97761 4425 42519092
Guillain-Barre syndrome 50.03 13.22 72 97746 7191 42516326
Enteritis 49.49 13.22 89 97729 10727 42512790
Abdominal discomfort 49.34 13.22 60 97758 75195 42448322
Tumour necrosis 48.98 13.22 36 97782 1608 42521909
Therapeutic product effect decreased 48.03 13.22 15 97803 39135 42484382
Treatment noncompliance 47.00 13.22 14 97804 37658 42485859
Autoimmune nephritis 46.59 13.22 20 97798 304 42523213
Blood cholesterol increased 46.47 13.22 4 97814 26737 42496780
Pleural effusion 46.20 13.22 381 97437 96785 42426732
Gastrooesophageal reflux disease 45.81 13.22 23 97795 45000 42478517
Erythema multiforme 45.52 13.22 82 97736 9895 42513622
Sinusitis 45.42 13.22 26 97792 47266 42476251
Sleep disorder 45.40 13.22 27 97791 48068 42475449
Contusion 44.94 13.22 20 97798 41965 42481552
Tachycardia 44.64 13.22 104 97714 100983 42422534
Metastases to central nervous system 44.58 13.22 83 97735 10272 42513245
Vomiting 44.35 13.22 438 97380 289285 42234232
Renal cell carcinoma recurrent 43.91 13.22 12 97806 38 42523479
Nephrolithiasis 43.62 13.22 15 97803 36815 42486702
Chest discomfort 43.55 13.22 49 97769 63567 42459950
Autoimmune arthritis 43.51 13.22 15 97803 120 42523397
Cancer pain 43.34 13.22 47 97771 3520 42519997
Contraindicated product administered 43.32 13.22 4 97814 25268 42498249
Abdominal pain 43.26 13.22 258 97560 190213 42333304
Primary hypothyroidism 43.24 13.22 14 97804 90 42523427
Fluid retention 42.77 13.22 10 97808 31609 42491908
Melanoma recurrent 42.58 13.22 16 97802 168 42523349
Sarcoid-like reaction 42.35 13.22 14 97804 97 42523420
Upper respiratory tract infection 42.23 13.22 22 97796 42151 42481366
Peripheral swelling 42.21 13.22 90 97728 90180 42433337
Drug intolerance 42.10 13.22 75 97743 80349 42443168
Paraneoplastic syndrome 41.95 13.22 25 97793 781 42522736
Autoimmune pancreatitis 41.66 13.22 20 97798 399 42523118
Weight increased 41.61 13.22 119 97699 107864 42415653
Tumour associated fever 41.19 13.22 22 97796 554 42522963
Heart rate increased 41.05 13.22 37 97781 53218 42470299
Lymphangiosis carcinomatosa 40.96 13.22 27 97791 1010 42522507
Febrile bone marrow aplasia 40.62 13.22 79 97739 10102 42513415
Coronary artery disease 40.60 13.22 38 97780 53682 42469835
Accidental overdose 40.27 13.22 8 97810 28322 42495195
Radiation necrosis 40.17 13.22 17 97801 249 42523268
Psychotic disorder 39.98 13.22 9 97809 29199 42494318
Off label use 39.68 13.22 1816 96002 636519 41886998
Immune-mediated oesophagitis 39.09 13.22 11 97807 40 42523477
Urticaria 38.79 13.22 69 97749 73967 42449550
Migraine 38.70 13.22 6 97812 25408 42498109
Hypersensitivity pneumonitis 38.62 13.22 34 97784 1970 42521547
Influenza 38.25 13.22 52 97766 62123 42461394
Sleep apnoea syndrome 38.19 13.22 3 97815 21605 42501912
Tissue infiltration 38.06 13.22 15 97803 181 42523336
Ventricular fibrillation 37.93 13.22 11 97807 30112 42493405
Drug reaction with eosinophilia and systemic symptoms 37.81 13.22 25 97793 42050 42481467
Pyrexia 37.62 13.22 1176 96642 392866 42130651
Obstructive airways disorder 37.35 13.22 6 97812 24753 42498764
Bronchitis 37.34 13.22 32 97786 47169 42476348
Palpitations 37.15 13.22 37 97781 50760 42472757
Cholecystitis 37.09 13.22 88 97730 12900 42510617
Autoimmune thyroiditis 36.99 13.22 30 97788 1552 42521965
Cardiac arrest 36.83 13.22 128 97690 109192 42414325
Hospitalisation 36.53 13.22 72 97746 74258 42449259
Dyskinesia 36.45 13.22 7 97811 25383 42498134
Drug-induced liver injury 36.31 13.22 179 97639 38094 42485423
Dyspnoea 36.25 13.22 758 97060 441863 42081654
Neutropenia 36.24 13.22 651 97167 198780 42324737
Small intestinal perforation 36.16 13.22 39 97779 2902 42520615
Dermatomyositis 35.99 13.22 30 97788 1613 42521904
Dermatitis 35.59 13.22 82 97736 11793 42511724
Malignant pleural effusion 35.36 13.22 32 97786 1923 42521594
Apoptosis 35.11 13.22 20 97798 573 42522944
Nasal congestion 34.96 13.22 12 97806 29489 42494028
Haematochezia 34.82 13.22 50 97768 58386 42465131
Angioedema 34.58 13.22 28 97790 42449 42481068
Abnormal behaviour 34.54 13.22 9 97809 26442 42497075
Mobility decreased 34.49 13.22 19 97799 35287 42488230
Mucosal inflammation 34.16 13.22 212 97606 49162 42474355
Cardiac tamponade 34.08 13.22 57 97761 6483 42517034
Full blood count abnormal 33.97 13.22 13 97805 29863 42493654
Haematoma 33.90 13.22 11 97807 28012 42495505
Balance disorder 33.38 13.22 36 97782 47609 42475908
Abdominal pain upper 33.34 13.22 89 97729 82520 42440997
Mixed liver injury 33.26 13.22 46 97772 4428 42519089
Respiratory arrest 32.93 13.22 12 97806 28412 42495105
Lethargy 32.22 13.22 36 97782 46854 42476663
Cardiac disorder 32.08 13.22 39 97779 48893 42474624
Orthostatic hypotension 32.03 13.22 15 97803 30555 42492962
Hallucination, visual 31.92 13.22 5 97813 21015 42502502
Silent thyroiditis 31.91 13.22 11 97807 88 42523429
Gastric stenosis 31.68 13.22 12 97806 129 42523388
Gastrointestinal perforation 31.67 13.22 45 97773 4441 42519076
Gait disturbance 31.51 13.22 117 97701 97883 42425634
Thrombosis 31.45 13.22 69 97749 68442 42455075
Duodenitis 31.08 13.22 50 97768 5506 42518011
Haemoglobin abnormal 31.01 13.22 47 97771 4917 42518600
Autoimmune myositis 30.81 13.22 19 97799 632 42522885
Troponin abnormal 30.79 13.22 10 97808 65 42523452
Heteroplasia 30.72 13.22 7 97811 7 42523510
Tinnitus 30.63 13.22 14 97804 28924 42494593
Accidental exposure to product 30.63 13.22 5 97813 20388 42503129
Adrenalectomy 30.48 13.22 6 97812 0 42523517
Incorrect route of product administration 30.37 13.22 9 97809 24296 42499221
Arthropathy 30.29 13.22 15 97803 29582 42493935
Hypoglycaemia 30.26 13.22 57 97761 59797 42463720
Lymphadenectomy 29.91 13.22 17 97801 485 42523032
Serotonin syndrome 29.79 13.22 11 97807 25834 42497683
Myocardial infarction 29.73 13.22 165 97653 123844 42399673
Hypophosphataemia 29.59 13.22 6 97812 20939 42502578
Radiotherapy to lung 29.37 13.22 7 97811 10 42523507
Glomerulonephritis rapidly progressive 29.35 13.22 21 97797 899 42522618
Pericardial effusion 29.27 13.22 139 97679 29136 42494381
Feeling abnormal 29.06 13.22 74 97744 69712 42453805
Lower respiratory tract infection 29.02 13.22 31 97787 41175 42482342
Drug level increased 28.80 13.22 12 97806 26188 42497329
Product prescribing error 28.64 13.22 12 97806 26100 42497417
Metabolic acidosis 28.38 13.22 47 97771 51811 42471706
Injection site swelling 28.27 13.22 3 97815 16970 42506547
Pericardial effusion malignant 28.19 13.22 9 97809 55 42523462
Primary adrenal insufficiency 28.17 13.22 14 97804 302 42523215
Miller Fisher syndrome 27.96 13.22 11 97807 132 42523385
Malaise 27.81 13.22 660 97158 211496 42312021
Paraneoplastic neurological syndrome 27.78 13.22 10 97808 92 42523425
Haematotoxicity 27.74 13.22 71 97747 10914 42512603
Irritability 27.68 13.22 15 97803 28113 42495404
Pulmonary oedema 27.58 13.22 50 97768 53222 42470295
Gout 27.55 13.22 15 97803 28040 42495477
Adrenalitis 27.45 13.22 8 97810 34 42523483
Pulmonary hypertension 27.22 13.22 10 97808 23559 42499958
Atrioventricular block complete 27.21 13.22 72 97746 11292 42512225
Thyroid function test abnormal 27.20 13.22 18 97800 678 42522839
Obesity 27.18 13.22 3 97815 16456 42507061
Blood thyroid stimulating hormone decreased 27.16 13.22 30 97788 2293 42521224
Discomfort 27.01 13.22 12 97806 25207 42498310
Viral infection 26.89 13.22 9 97809 22474 42501043
Renal tubular necrosis 26.89 13.22 98 97720 18256 42505261
Cough 26.89 13.22 270 97548 177833 42345684
Lung opacity 26.66 13.22 48 97770 5789 42517728
Intestinal intraepithelial lymphocytes increased 26.58 13.22 12 97806 207 42523310
Nephropathy toxic 26.46 13.22 92 97726 16746 42506771
Product administration error 26.45 13.22 5 97813 18338 42505179
Therapy interrupted 26.45 13.22 9 97809 22241 42501276
Tumour embolism 26.44 13.22 10 97808 107 42523410
Acute promyelocytic leukaemia 26.28 13.22 18 97800 718 42522799
Cryptitis 26.26 13.22 13 97805 278 42523239
Dermatitis bullous 26.02 13.22 59 97759 8397 42515120
Glucocorticoid deficiency 25.95 13.22 16 97802 532 42522985
Diffuse panbronchiolitis 25.85 13.22 6 97812 7 42523510
Cancer surgery 25.82 13.22 16 97802 537 42522980
Respiratory failure 25.67 13.22 425 97393 127707 42395810
Pneumocystis jirovecii pneumonia 25.49 13.22 120 97698 25061 42498456
Chronic obstructive pulmonary disease 25.46 13.22 68 97750 63046 42460471
Respiratory depression 25.45 13.22 6 97812 18862 42504655
Melaena 25.27 13.22 31 97787 38715 42484802
Disturbance in attention 25.18 13.22 19 97799 29847 42493670
Cytokine storm 25.08 13.22 19 97799 889 42522628
Hyperlipidaemia 25.07 13.22 9 97809 21507 42502010
Splenic calcification 25.00 13.22 6 97812 9 42523508
Acquired tracheo-oesophageal fistula 24.98 13.22 10 97808 126 42523391
Disorientation 24.93 13.22 28 97790 36361 42487156
Injury 24.89 13.22 10 97808 22306 42501211
Leukoderma 24.70 13.22 9 97809 86 42523431
Radiotherapy to bone 24.61 13.22 6 97812 10 42523507
Memory impairment 24.37 13.22 49 97769 50173 42473344
Body surface area decreased 24.25 13.22 6 97812 11 42523506
Mental status changes 24.15 13.22 37 97781 42078 42481439
Heart rate decreased 24.07 13.22 29 97789 36503 42487014
Vertigo 24.00 13.22 26 97792 34321 42489196
Gastrointestinal haemorrhage 23.98 13.22 129 97689 97597 42425920
Unresponsive to stimuli 23.98 13.22 22 97796 31381 42492136
Depressed level of consciousness 23.97 13.22 46 97772 47924 42475593
Cataract 23.90 13.22 21 97797 30583 42492934
Eosinophil percentage decreased 23.89 13.22 12 97806 265 42523252
Autoimmune disorder 23.85 13.22 29 97789 2458 42521059
Therapeutic response decreased 23.74 13.22 30 97788 36982 42486535
Malignant ascites 23.73 13.22 16 97802 622 42522895
Blood pressure increased 23.68 13.22 137 97681 101791 42421726
Skin reaction 23.65 13.22 51 97767 7016 42516501
Lung squamous cell carcinoma recurrent 23.59 13.22 6 97812 13 42523504
Delusion 23.55 13.22 3 97815 14731 42508786
Erectile dysfunction 23.49 13.22 14 97804 24899 42498618
Poisoning 23.48 13.22 3 97815 14696 42508821
Retroperitoneal fibrosis 23.47 13.22 14 97804 438 42523079
Treatment failure 23.39 13.22 70 97748 62554 42460963
Necrotising myositis 23.28 13.22 20 97798 1121 42522396
Cardiomegaly 23.28 13.22 5 97813 16761 42506756
Hepatitis cholestatic 23.27 13.22 62 97756 9762 42513755
Cachexia 23.24 13.22 55 97763 8049 42515468
Endocrine disorder 23.19 13.22 13 97805 361 42523156
Transient ischaemic attack 23.07 13.22 26 97792 33713 42489804
Transitional cell carcinoma recurrent 22.99 13.22 6 97812 15 42523502
Restlessness 22.92 13.22 20 97798 29229 42494288
Lymphocytic hypophysitis 22.81 13.22 13 97805 373 42523144
Non-small cell lung cancer recurrent 22.78 13.22 8 97810 68 42523449
Trichoglossia 22.78 13.22 13 97805 374 42523143
Blood creatine phosphokinase abnormal 22.68 13.22 13 97805 377 42523140
Cholestasis 22.63 13.22 141 97677 32738 42490779
Basal cell carcinoma 22.55 13.22 12 97806 22721 42500796
Chemotherapy 22.54 13.22 17 97801 790 42522727
Lung adenocarcinoma recurrent 22.47 13.22 5 97813 4 42523513
Feeling hot 22.41 13.22 13 97805 23469 42500048
Cerebrovascular accident 22.35 13.22 131 97687 97029 42426488
Liver ablation 22.20 13.22 6 97812 18 42523499
Seronegative arthritis 22.07 13.22 20 97798 1204 42522313
Therapeutic product effect incomplete 21.95 13.22 86 97732 70853 42452664
Autoimmune uveitis 21.94 13.22 5 97813 5 42523512
Presyncope 21.94 13.22 12 97806 22375 42501142
Myoclonus 21.91 13.22 6 97812 17059 42506458
Cytokine release syndrome 21.90 13.22 176 97642 44351 42479166
Chronic inflammatory demyelinating polyradiculoneuropathy 21.86 13.22 20 97798 1219 42522298
Visual impairment 21.84 13.22 41 97777 43072 42480445
Myasthenia gravis crisis 21.83 13.22 17 97801 829 42522688
Osteoporosis 21.63 13.22 4 97814 14902 42508615
Amnesia 21.62 13.22 20 97798 28417 42495100
Feeding disorder 21.56 13.22 55 97763 8436 42515081
Procalcitonin decreased 21.46 13.22 11 97807 254 42523263
Optic neuritis 21.45 13.22 36 97782 4106 42519411
Rhabdomyolysis 21.42 13.22 99 97719 77920 42445597
Swelling face 21.40 13.22 19 97799 27535 42495982
Thrombocytopenia 21.40 13.22 580 97238 189699 42333818
Swollen tongue 21.36 13.22 11 97807 21220 42502297
Localised infection 21.34 13.22 10 97808 20363 42503154
Vogt-Koyanagi-Harada disease 21.27 13.22 10 97808 190 42523327
Acute kidney injury 21.17 13.22 1038 96780 366299 42157218
Rectal haemorrhage 21.12 13.22 52 97766 49554 42473963
Therapeutic response shortened 21.10 13.22 3 97815 13551 42509966
Post procedural oedema 21.08 13.22 6 97812 23 42523494
Anaemia 21.04 13.22 814 97004 279464 42244053
Carcinoembryonic antigen increased 20.93 13.22 17 97801 881 42522636
Dysarthria 20.93 13.22 37 97781 39770 42483747
Blood creatine decreased 20.85 13.22 11 97807 270 42523247
Lip swelling 20.51 13.22 9 97809 19044 42504473
Keratoacanthoma 20.51 13.22 17 97801 907 42522610
Visceral venous thrombosis 20.49 13.22 6 97812 26 42523491
Hypervolaemia 20.42 13.22 14 97804 23111 42500406
Large intestine perforation 20.42 13.22 58 97760 9478 42514039
Ocular myasthenia 20.34 13.22 14 97804 563 42522954
Oesophagitis 20.33 13.22 79 97739 15168 42508349
Thyroid gland injury 20.32 13.22 4 97814 0 42523517
Hyperglycaemia 20.28 13.22 177 97641 45682 42477835
Recurrent cancer 20.25 13.22 22 97796 1651 42521866
Autoimmune haemolytic anaemia 20.23 13.22 42 97776 5629 42517888
Head injury 20.21 13.22 11 97807 20571 42502946
Haemorrhoids 20.18 13.22 7 97811 17090 42506427
Rhinorrhoea 20.15 13.22 26 97792 31768 42491749
Vision blurred 20.07 13.22 60 97758 53639 42469878
Epistaxis 20.05 13.22 82 97736 66744 42456773
Probiotic therapy 20.00 13.22 9 97809 154 42523363
Autoimmune neuropathy 19.99 13.22 7 97811 59 42523458
Skin laceration 19.92 13.22 4 97814 14054 42509463
Physical deconditioning 19.82 13.22 26 97792 2379 42521138
Prescribed overdose 19.80 13.22 3 97815 12924 42510593
Melanosis 19.79 13.22 6 97812 30 42523487
Pleural thickening 19.78 13.22 13 97805 484 42523033
Blood triglycerides increased 19.66 13.22 6 97812 15890 42507627
Liver scan abnormal 19.61 13.22 5 97813 11 42523506
Adverse drug reaction 19.50 13.22 35 97783 37399 42486118
Renal tubular disorder 19.47 13.22 38 97780 4871 42518646
Pulmonary resection 19.42 13.22 8 97810 109 42523408
Microvillous inclusion disease 19.42 13.22 10 97808 233 42523284
Gastrointestinal stenosis 19.39 13.22 9 97809 166 42523351
Primary biliary cholangitis 19.32 13.22 11 97807 315 42523202
Autoimmune blistering disease 19.31 13.22 5 97813 12 42523505
Platelet count abnormal 19.27 13.22 32 97786 3617 42519900
Joint injury 19.15 13.22 5 97813 14671 42508846
Hot flush 19.12 13.22 14 97804 22337 42501180
Bacterial diarrhoea 19.10 13.22 9 97809 172 42523345
Cardiac failure 19.08 13.22 348 97470 106508 42417009
Liver function test abnormal 19.01 13.22 28 97790 32363 42491154
Drug effective for unapproved indication 19.00 13.22 45 97773 6588 42516929
Enterocolitis 18.98 13.22 58 97760 9871 42513646
Skin erosion 18.95 13.22 28 97790 2863 42520654
Limbic encephalitis 18.91 13.22 12 97806 420 42523097
Oesophageal carcinoma recurrent 18.88 13.22 6 97812 36 42523481
Cellulitis 18.84 13.22 75 97743 61510 42462007
Flagellate dermatitis 18.79 13.22 8 97810 119 42523398
Aortitis 18.73 13.22 14 97804 642 42522875
Lung disorder 18.68 13.22 180 97638 47743 42475774
Oral lichenoid reaction 18.55 13.22 8 97810 123 42523394
Gastrointestinal toxicity 18.53 13.22 33 97785 3946 42519571
Mucocutaneous rash 18.48 13.22 6 97812 39 42523478
Rheumatic disorder 18.44 13.22 14 97804 657 42522860
Pharyngeal inflammation 18.42 13.22 14 97804 658 42522859
Transaminases increased 18.42 13.22 134 97684 32751 42490766
Generalised tonic-clonic seizure 18.40 13.22 20 97798 26359 42497158
Multiple sclerosis relapse 18.35 13.22 5 97813 14259 42509258
Emotional distress 18.30 13.22 7 97811 16086 42507431
Enostosis 18.26 13.22 5 97813 16 42523501
Paraneoplastic dermatomyositis 18.26 13.22 7 97811 78 42523439
Blood glucose increased 18.23 13.22 97 97721 73602 42449915
Hyperkalaemia 18.23 13.22 109 97709 80349 42443168
Renal cancer recurrent 18.22 13.22 6 97812 41 42523476
Heart rate irregular 18.22 13.22 7 97811 16043 42507474
Aspartate aminotransferase abnormal 18.10 13.22 16 97802 932 42522585
Sialoadenitis 18.10 13.22 15 97803 800 42522717
Impaired work ability 18.08 13.22 3 97815 12088 42511429
Tachypnoea 17.98 13.22 14 97804 21648 42501869
Liver abscess 17.95 13.22 37 97781 4933 42518584
Osteonecrosis 17.87 13.22 7 97811 15858 42507659
Rhinitis 17.85 13.22 3 97815 11974 42511543
Angina pectoris 17.82 13.22 30 97788 32866 42490651
Aspergillus infection 17.82 13.22 7 97811 15830 42507687
Hyperphosphataemia 17.81 13.22 4 97814 13000 42510517
Acute interstitial pneumonitis 17.80 13.22 13 97805 575 42522942
Cutaneous lupus erythematosus 17.61 13.22 15 97803 831 42522686
Paralysis recurrent laryngeal nerve 17.43 13.22 7 97811 89 42523428
Latent autoimmune diabetes in adults 17.31 13.22 8 97810 146 42523371
Rash maculovesicular 17.30 13.22 6 97812 49 42523468
Blood uric acid increased 17.28 13.22 7 97811 15540 42507977
Haemorrhage 17.13 13.22 76 97742 60487 42463030
Body temperature increased 17.10 13.22 13 97805 20345 42503172
Immune-mediated cholestasis 17.09 13.22 4 97814 5 42523512
Lymphadenopathy 17.02 13.22 133 97685 33232 42490285
Cortisol abnormal 16.98 13.22 6 97812 52 42523465
Ophthalmoplegia 16.93 13.22 23 97795 2177 42521340
Pollakiuria 16.91 13.22 16 97802 22489 42501028
Tracheostomy 16.87 13.22 16 97802 1021 42522496
Infectious pleural effusion 16.85 13.22 28 97790 3167 42520350
Chronic kidney disease 16.80 13.22 54 97764 47187 42476330
Skin cancer 16.80 13.22 3 97815 11459 42512058
Tracheal fistula 16.78 13.22 8 97810 157 42523360
Pathogen resistance 16.77 13.22 3 97815 11447 42512070
Lymphadenopathy mediastinal 16.75 13.22 28 97790 3183 42520334
Myocardial ischaemia 16.72 13.22 10 97808 17752 42505765
Rales 16.67 13.22 3 97815 11397 42512120
Non-small cell lung cancer stage III 16.67 13.22 4 97814 6 42523511
Carditis 16.55 13.22 9 97809 235 42523282
Flatulence 16.53 13.22 20 97798 25132 42498385
Right ventricular ejection fraction decreased 16.50 13.22 6 97812 57 42523460
Impaired quality of life 16.40 13.22 6 97812 14171 42509346
Staphylococcal infection 16.39 13.22 39 97779 37604 42485913
Paraesthesia 16.39 13.22 100 97718 73359 42450158
Influenza like illness 16.38 13.22 30 97788 31810 42491707
Supportive care 16.29 13.22 4 97814 7 42523510
Pancreatic failure 16.23 13.22 16 97802 1071 42522446
COVID-19 16.17 13.22 179 97639 115769 42407748
End stage renal disease 16.04 13.22 9 97809 16549 42506968
Infected neoplasm 15.96 13.22 8 97810 176 42523341
Metastases to skin 15.94 13.22 12 97806 556 42522961
Mitral valve incompetence 15.92 13.22 9 97809 16480 42507037
Enterococcal infection 15.90 13.22 4 97814 12035 42511482
Intestinal perforation 15.87 13.22 58 97760 10816 42512701
Systemic scleroderma 15.77 13.22 12 97806 565 42522952
Pneumonia aspiration 15.71 13.22 180 97638 49898 42473619
Hypercholesterolaemia 15.62 13.22 5 97813 12844 42510673
Bicytopenia 15.60 13.22 27 97791 3157 42520360
Neutrophil count abnormal 15.58 13.22 25 97793 2746 42520771
Gastroduodenal ulcer 15.55 13.22 13 97805 702 42522815
Bacterial infection 15.50 13.22 25 97793 27854 42495663
Bladder cancer 15.49 13.22 10 97808 17037 42506480
Scleroderma-like reaction 15.48 13.22 6 97812 69 42523448
Pain in jaw 15.37 13.22 7 97811 14495 42509022
Diffuse uveal melanocytic proliferation 15.33 13.22 4 97814 10 42523507
Back pain 15.29 13.22 231 97587 141545 42381972
Renal vein embolism 15.24 13.22 3 97815 0 42523517
Gamma radiation therapy 15.24 13.22 3 97815 0 42523517
Pulmonary imaging procedure abnormal 15.24 13.22 3 97815 0 42523517
Computerised tomogram kidney abnormal 15.24 13.22 3 97815 0 42523517
Nervousness 15.20 13.22 6 97812 13526 42509991
Cardio-respiratory arrest 15.17 13.22 76 97742 58560 42464957
Platelet count decreased 15.16 13.22 421 97397 138160 42385357
Blood folate decreased 15.11 13.22 14 97804 867 42522650
Hip fracture 15.08 13.22 6 97812 13466 42510051
Road traffic accident 15.03 13.22 13 97805 19080 42504437
Nausea 15.03 13.22 751 97067 396048 42127469
Ketoacidosis 15.00 13.22 36 97782 5316 42518201
Arthralgia 14.87 13.22 358 97460 204880 42318637
Oropharyngeal pain 14.83 13.22 49 97769 42461 42481056
Pneumocystis test positive 14.80 13.22 4 97814 12 42523505
Dermatitis atopic 14.77 13.22 5 97813 12399 42511118
Angina unstable 14.75 13.22 4 97814 11444 42512073
Tumour perforation 14.65 13.22 11 97807 508 42523009
Subdural haematoma 14.58 13.22 19 97799 23119 42500398
Abdominal infection 14.54 13.22 23 97795 2496 42521021
Thyroxine decreased 14.47 13.22 8 97810 216 42523301
Blood creatine abnormal 14.47 13.22 8 97810 216 42523301
Chills 14.43 13.22 142 97676 93924 42429593
Hypoacusis 14.40 13.22 13 97805 18689 42504828
Disease recurrence 14.36 13.22 29 97789 29649 42493868
Peripheral sensorimotor neuropathy 14.36 13.22 20 97798 1938 42521579
Bacteraemia 14.35 13.22 22 97796 25018 42498499
Synovitis 14.32 13.22 9 97809 15558 42507959
Pulmonary sarcoidosis 14.28 13.22 13 97805 787 42522730
Cortisol increased 14.21 13.22 8 97810 224 42523293
Breath sounds abnormal 14.19 13.22 5 97813 12088 42511429
Orbital myositis 14.13 13.22 7 97811 150 42523367
Catheter site rash 14.11 13.22 8 97810 227 42523290
Flushing 14.11 13.22 41 97777 36987 42486530
Alanine aminotransferase increased 14.10 13.22 283 97535 88123 42435394
Frequent bowel movements 14.09 13.22 17 97801 21390 42502127
Hyperplastic cholecystopathy 14.09 13.22 5 97813 44 42523473
Vocal cord paresis 14.04 13.22 7 97811 152 42523365
Fatigue 14.04 13.22 1171 96647 434470 42089047
Rash pruritic 13.99 13.22 128 97690 33475 42490042
General physical health deterioration 13.99 13.22 450 97368 150796 42372721
Tooth disorder 13.97 13.22 5 97813 11974 42511543
Adrenal gland cancer metastatic 13.92 13.22 4 97814 16 42523501
Duodenal perforation 13.88 13.22 18 97800 1628 42521889
Cutaneous sarcoidosis 13.84 13.22 7 97811 157 42523360
Micturition urgency 13.82 13.22 5 97813 11893 42511624
Pulmonary cavitation 13.82 13.22 16 97802 1288 42522229
Aortic valve calcification 13.82 13.22 11 97807 554 42522963
Tumour ulceration 13.81 13.22 6 97812 94 42523423
Haematocrit decreased 13.78 13.22 38 97780 34870 42488647
Granulocyte count increased 13.78 13.22 10 97808 438 42523079
Biopsy 13.76 13.22 9 97809 332 42523185
Axonal and demyelinating polyneuropathy 13.75 13.22 6 97812 95 42523422
Dry mouth 13.72 13.22 146 97672 39733 42483784
Red blood cell sedimentation rate increased 13.70 13.22 3 97815 9921 42513596
Aspartate aminotransferase increased 13.66 13.22 251 97567 76912 42446605
Tendonitis 13.64 13.22 3 97815 9891 42513626
Limb injury 13.54 13.22 8 97810 14297 42509220
Bacterial prostatitis 13.53 13.22 6 97812 99 42523418
Dyspepsia 13.52 13.22 49 97769 41303 42482214
Amylase increased 13.51 13.22 40 97778 6689 42516828
Osteoarthritis 13.46 13.22 22 97796 24383 42499134
Cyanosis 13.41 13.22 9 97809 15022 42508495
Neuralgia 13.34 13.22 24 97794 25623 42497894
Skin discolouration 13.32 13.22 17 97801 20873 42502644
Thyroid hormones increased 13.32 13.22 6 97812 103 42523414
Tumour lysis syndrome 13.27 13.22 92 97726 22139 42501378
Autoimmune encephalopathy 13.26 13.22 5 97813 53 42523464
Blindness 13.25 13.22 13 97805 17965 42505552
Hepatic enzyme increased 13.22 13.22 162 97656 45622 42477895

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 14011.98 13.31 6437 174356 168130 110240376
Hypothyroidism 3511.34 13.31 1908 178885 70991 110337515
Immune-mediated hepatic disorder 2987.99 13.31 804 179989 3646 110404860
Therapy partial responder 2762.98 13.31 1304 179489 35757 110372749
Immune-mediated enterocolitis 2425.11 13.31 828 179965 9357 110399149
Immune-mediated myocarditis 2198.62 13.31 600 180193 2898 110405608
Immune-mediated hypothyroidism 2022.50 13.31 539 180254 2336 110406170
Interstitial lung disease 1744.16 13.31 1596 179197 137738 110270768
Immune-mediated lung disease 1742.05 13.31 550 180243 4753 110403753
Immune-mediated adverse reaction 1715.99 13.31 425 180368 1275 110407231
Myocarditis 1672.69 13.31 867 179926 29188 110379318
Adrenal insufficiency 1671.82 13.31 974 179819 41416 110367090
Immune-mediated hepatitis 1475.00 13.31 514 180279 6197 110402309
Pneumonitis 1345.41 13.31 1066 179727 75465 110333041
Immune-mediated adrenal insuficiency 1344.06 13.31 353 180440 1427 110407079
Immune-mediated dermatitis 1215.14 13.31 344 180449 1946 110406560
Tumour pseudoprogression 1193.96 13.31 315 180478 1301 110407205
Palmar-plantar erythrodysaesthesia syndrome 1167.99 13.31 766 180027 40259 110368247
Type 1 diabetes mellitus 1057.95 13.31 437 180356 8610 110399896
Tubulointerstitial nephritis 1036.03 13.31 794 179999 53490 110355016
Proteinuria 1035.20 13.31 704 180089 39314 110369192
Thyroiditis 1032.68 13.31 393 180400 6180 110402326
Colitis 998.79 13.31 1023 179770 101300 110307206
Hyperthyroidism 938.42 13.31 589 180204 28672 110379834
Neuropathy peripheral 857.22 13.31 1249 179544 178028 110230478
Immune-mediated renal disorder 851.71 13.31 206 180587 541 110407965
Adrenocorticotropic hormone deficiency 833.19 13.31 254 180539 1928 110406578
Hepatic cytolysis 769.95 13.31 672 180121 54381 110354125
Hepatic function abnormal 732.07 13.31 814 179979 88481 110320025
Immune-mediated thyroiditis 730.80 13.31 197 180596 899 110407607
Hypophysitis 696.20 13.31 280 180513 5135 110403371
Radiotherapy 675.60 13.31 198 180595 1290 110407216
Immune-mediated myositis 673.51 13.31 284 180509 5902 110402604
Myelosuppression 667.38 13.31 797 179996 93543 110314963
Neutropenia 642.11 13.31 1691 179102 372929 110035577
Hypertension 612.15 13.31 2028 178765 508056 109900450
Renal impairment 611.09 13.31 1101 179692 187344 110221162
Death 593.48 13.31 2485 178308 696384 109712122
Product use in unapproved indication 589.58 13.31 1837 178956 445540 109962966
Immune-mediated pancreatitis 587.25 13.31 152 180641 572 110407934
Decreased appetite 547.83 13.31 1866 178927 473980 109934526
Immune-mediated arthritis 510.66 13.31 134 180659 539 110407967
Myositis 509.43 13.31 416 180377 30700 110377806
Immune-mediated encephalitis 503.78 13.31 150 180643 1040 110407466
Lichenoid keratosis 488.54 13.31 228 180565 6074 110402432
Pulmonary toxicity 487.08 13.31 324 180469 17422 110391084
Joint swelling 484.66 13.31 73 180720 442772 109965734
Eastern Cooperative Oncology Group performance status worsened 482.55 13.31 182 180611 2787 110405719
Immune-mediated hypophysitis 473.98 13.31 137 180656 844 110407662
Cholangitis 469.62 13.31 307 180486 16028 110392478
Pancytopenia 464.20 13.31 1045 179748 208568 110199938
Platelet count decreased 451.50 13.31 1095 179698 229348 110179158
Immune-mediated hyperthyroidism 442.90 13.31 118 180675 510 110407996
Nephritis 420.99 13.31 204 180589 5922 110402584
Nasopharyngitis 415.78 13.31 72 180721 394289 110014217
Pain 410.56 13.31 579 180214 954376 109454130
Immune-mediated gastritis 399.70 13.31 96 180697 242 110408264
Immune-mediated cholangitis 394.18 13.31 116 180677 768 110407738
Blood thyroid stimulating hormone increased 390.27 13.31 246 180547 12055 110396451
Hepatitis 386.57 13.31 597 180196 89457 110319049
Swelling 383.69 13.31 58 180735 350983 110057523
Myasthenia gravis 380.61 13.31 301 180492 21210 110387296
Immune-mediated nephritis 376.62 13.31 121 180672 1111 110407395
Headache 368.31 13.31 546 180247 881831 109526675
Synovitis 363.33 13.31 21 180772 274071 110134435
Contraindicated product administered 363.03 13.31 9 180784 248258 110160248
Abdominal discomfort 362.22 13.31 98 180695 393760 110014746
Drug hypersensitivity 356.67 13.31 148 180645 453942 109954564
Completed suicide 353.60 13.31 9 180784 242372 110166134
Arthropathy 352.59 13.31 32 180761 287490 110121016
Toxic epidermal necrolysis 349.12 13.31 447 180346 56280 110352226
Skin toxicity 347.41 13.31 225 180568 11558 110396948
Drug interaction 347.13 13.31 193 180600 499990 109908516
Fall 342.86 13.31 290 180503 603192 109805314
Autoimmune hepatitis 341.85 13.31 243 180550 14561 110393945
Diarrhoea 341.30 13.31 3091 177702 1136414 109272092
Haemophagocytic lymphohistiocytosis 339.78 13.31 333 180460 31226 110377280
Dizziness 337.42 13.31 387 180406 697806 109710700
Neoplasm progression 331.75 13.31 466 180327 64129 110344377
Tumour hyperprogression 322.08 13.31 82 180711 284 110408222
Maternal exposure during pregnancy 321.78 13.31 25 180768 254858 110153648
Skin disorder 320.65 13.31 373 180420 42540 110365966
Therapeutic product effect decreased 319.93 13.31 20 180773 244296 110164210
Sinusitis 319.68 13.31 51 180742 296637 110111869
Inappropriate schedule of product administration 312.08 13.31 883 179910 202754 110205752
Neutrophil count decreased 310.03 13.31 640 180153 120301 110288205
Pemphigus 309.14 13.31 9 180784 214561 110193945
Diabetic ketoacidosis 308.30 13.31 362 180431 41696 110366810
Hypopituitarism 301.09 13.31 146 180647 4244 110404262
Pyrexia 299.45 13.31 2496 178297 895769 109512737
Musculoskeletal stiffness 297.23 13.31 50 180743 279772 110128734
Pemphigoid 296.64 13.31 251 180542 19456 110389050
Drug intolerance 296.53 13.31 147 180646 406365 110002141
Fulminant type 1 diabetes mellitus 296.22 13.31 120 180673 2243 110406263
Thrombocytopenia 295.37 13.31 1241 179552 347644 110060862
Wound 293.12 13.31 24 180769 234413 110174093
Febrile neutropenia 289.67 13.31 1154 179639 315613 110092893
Secondary adrenocortical insufficiency 287.75 13.31 142 180651 4292 110404214
Peripheral swelling 287.40 13.31 151 180642 403883 110004623
Systemic lupus erythematosus 287.27 13.31 38 180755 254300 110154206
Wheezing 286.22 13.31 39 180754 255191 110153315
Weight increased 283.83 13.31 167 180626 419477 109989029
Intentional product use issue 282.50 13.31 36 180757 247870 110160636
Autoimmune colitis 280.84 13.31 110 180683 1875 110406631
Acute kidney injury 280.19 13.31 1887 178906 633543 109774963
Hypersensitivity 280.05 13.31 156 180637 403842 110004664
Depression 276.96 13.31 87 180706 317248 110091258
Glossodynia 274.07 13.31 24 180769 221980 110186526
Vitiligo 267.97 13.31 120 180673 2897 110405609
Duodenal ulcer perforation 265.42 13.31 5 180788 177695 110230811
Contusion 260.85 13.31 36 180757 233325 110175181
Dysphonia 259.16 13.31 454 180339 75475 110333031
Asthma 256.54 13.31 49 180744 250242 110158264
Product use issue 256.22 13.31 1099 179694 310596 110097910
Insomnia 253.14 13.31 137 180656 360453 110048053
Exposure during pregnancy 253.01 13.31 4 180789 167420 110241086
Drug eruption 250.49 13.31 370 180423 53289 110355217
Autoimmune hypothyroidism 249.72 13.31 72 180721 439 110408067
Irritable bowel syndrome 247.83 13.31 4 180789 164211 110244295
Rash maculo-papular 247.13 13.31 439 180354 73783 110334723
Condition aggravated 246.35 13.31 521 180272 734315 109674191
Blood cholesterol increased 245.32 13.31 14 180779 184771 110223735
Discomfort 245.06 13.31 31 180762 214676 110193830
Mobility decreased 242.24 13.31 47 180746 237375 110171131
Overdose 241.26 13.31 45 180748 233749 110174757
Injury 239.80 13.31 12 180781 177253 110231253
Lower respiratory tract infection 237.98 13.31 53 180740 243053 110165453
Anaemia 237.01 13.31 1618 179175 545468 109863038
Troponin increased 236.32 13.31 267 180526 29499 110379007
Folliculitis 234.53 13.31 9 180784 167644 110240862
Muscle spasms 229.25 13.31 84 180709 278073 110130433
Injection site pain 225.80 13.31 17 180776 177905 110230601
Pain in extremity 223.37 13.31 281 180512 486837 109921669
Thyroid disorder 220.93 13.31 199 180594 16770 110391736
Hepatotoxicity 220.15 13.31 382 180411 63018 110345488
Glucocorticoid deficiency 219.81 13.31 80 180713 1102 110407404
Stevens-Johnson syndrome 216.91 13.31 322 180471 46579 110361927
Renal tubular necrosis 216.23 13.31 258 180535 30217 110378289
Migraine 216.15 13.31 17 180776 171635 110236871
Myasthenic syndrome 213.84 13.31 80 180713 1196 110407310
Adrenal disorder 210.49 13.31 95 180698 2337 110406169
Muscle injury 210.12 13.31 4 180789 140803 110267703
Encephalitis 206.92 13.31 201 180592 18638 110389868
Blood corticotrophin decreased 205.77 13.31 70 180723 780 110407726
Anxiety 205.51 13.31 158 180635 344920 110063586
Febrile bone marrow aplasia 204.44 13.31 193 180600 17272 110391234
Cholangitis sclerosing 203.97 13.31 105 180688 3477 110405029
Immune-mediated neuropathy 201.81 13.31 51 180742 170 110408336
Immune-mediated endocrinopathy 201.54 13.31 47 180746 99 110408407
Immune-mediated cytopenia 201.40 13.31 55 180738 266 110408240
Intentional overdose 200.90 13.31 3 180790 132498 110276008
Osteoarthritis 195.29 13.31 32 180761 182591 110225915
Psoriatic arthropathy 192.35 13.31 43 180750 196718 110211788
Confusional state 192.17 13.31 293 180500 468387 109940119
Immune thrombocytopenia 191.01 13.31 209 180584 22285 110386221
Cortisol decreased 190.54 13.31 93 180700 2743 110405763
Hypertransaminasaemia 188.19 13.31 215 180578 24040 110384466
Bursitis 181.62 13.31 7 180786 129911 110278595
Hypothalamo-pituitary disorder 181.29 13.31 90 180703 2756 110405750
Infusion related reaction 179.81 13.31 215 180578 380947 110027559
Autoimmune thyroiditis 170.61 13.31 115 180678 6319 110402187
Radiation pneumonitis 162.42 13.31 98 180695 4438 110404068
Drug ineffective 161.97 13.31 1649 179144 1518891 108889615
Erythema multiforme 160.30 13.31 185 180608 20912 110387594
Mucosal inflammation 159.14 13.31 429 180364 95712 110312794
Sleep disorder 158.62 13.31 63 180730 198581 110209925
Immune-mediated neurological disorder 158.25 13.31 35 180758 51 110408455
Cholecystitis 157.71 13.31 203 180590 25679 110382827
Intentional product misuse 157.07 13.31 17 180776 132887 110275619
Polymyalgia rheumatica 156.29 13.31 109 180684 6333 110402173
Cytokine release syndrome 155.95 13.31 351 180442 69955 110338551
Obesity 155.46 13.31 7 180786 113344 110295162
Small intestinal perforation 152.71 13.31 93 180700 4283 110404223
Impaired healing 151.26 13.31 66 180727 196651 110211855
Suicide attempt 150.13 13.31 4 180789 103390 110305116
Urticaria 149.14 13.31 181 180612 318676 110089830
Loss of personal independence in daily activities 148.21 13.31 32 180761 149988 110258518
Treatment failure 147.86 13.31 141 180652 277093 110131413
Toxicity to various agents 146.76 13.31 358 180435 480197 109928309
Joint range of motion decreased 145.48 13.31 15 180778 121817 110286689
Pericarditis 144.09 13.31 90 180703 219024 110189482
Immune-mediated cystitis 143.15 13.31 36 180757 117 110408389
Product dose omission issue 142.88 13.31 190 180603 321592 110086914
Abdominal pain upper 142.31 13.31 219 180574 348892 110059614
Gastrointestinal perforation 142.01 13.31 109 180684 7347 110401159
Injection site erythema 139.21 13.31 3 180790 94173 110314333
Lip dry 137.85 13.31 6 180787 100077 110308429
Tumour haemorrhage 137.29 13.31 93 180700 5152 110403354
Medication error 136.76 13.31 9 180784 105357 110303149
Eyelid ptosis 134.89 13.31 136 180657 13191 110395315
Gastrooesophageal reflux disease 134.28 13.31 63 180730 179913 110228593
Immune-mediated uveitis 134.27 13.31 39 180754 245 110408261
Subacute cutaneous lupus erythematosus 134.19 13.31 90 180703 4904 110403602
Dermatitis bullous 133.66 13.31 154 180639 17375 110391131
Pseudocellulitis 133.15 13.31 43 180750 402 110408104
Silent thyroiditis 130.28 13.31 39 180754 276 110408230
Bronchitis 130.04 13.31 47 180746 156985 110251521
Cardiac failure 129.74 13.31 629 180164 186997 110221509
Urogenital fistula 129.08 13.31 42 180751 403 110408103
Adrenocortical insufficiency acute 128.96 13.31 84 180709 4356 110404150
Enterocolitis 128.83 13.31 157 180636 18792 110389714
Tumour associated fever 128.71 13.31 54 180739 1107 110407399
Meningitis aseptic 127.01 13.31 115 180678 9755 110398751
Guillain-Barre syndrome 126.27 13.31 119 180674 10625 110397881
Eosinophilic fasciitis 125.50 13.31 40 180753 357 110408149
Cholestasis 124.45 13.31 305 180488 64213 110344293
Type 2 diabetes mellitus 123.31 13.31 68 180725 177164 110231342
Memory impairment 122.59 13.31 86 180707 196858 110211648
Night sweats 121.79 13.31 34 180759 133949 110274557
KL-6 increased 121.45 13.31 37 180756 280 110408226
Wound infection 120.18 13.31 10 180783 96455 110312051
Pleural effusion 119.46 13.31 591 180202 177118 110231388
Suicidal ideation 119.10 13.31 9 180784 93928 110314578
Road traffic accident 118.95 13.31 17 180776 107381 110301125
Prescribed overdose 118.20 13.31 6 180787 87575 110320931
Encephalitis autoimmune 115.54 13.31 72 180721 3456 110405050
Lichen planus 115.24 13.31 71 180722 3339 110405167
Thrombophlebitis migrans 113.42 13.31 44 180749 730 110407776
Hyperhidrosis 112.40 13.31 85 180708 187213 110221293
C-reactive protein abnormal 112.28 13.31 36 180757 129659 110278847
Product quality issue 112.19 13.31 3 180790 77296 110331210
Hypercholesterolaemia 111.58 13.31 10 180783 90827 110317679
Sciatica 111.29 13.31 11 180782 92388 110316118
Lower limb fracture 109.08 13.31 3 180790 75345 110333161
Blood thyroid stimulating hormone decreased 108.52 13.31 92 180701 7147 110401359
Pneumonia bacterial 108.31 13.31 171 180622 26090 110382416
Autoimmune nephritis 108.30 13.31 43 180750 761 110407745
Musculoskeletal pain 107.36 13.31 85 180708 182938 110225568
Stress 107.10 13.31 21 180772 105327 110303179
Somnolence 105.29 13.31 204 180589 297245 110111261
Immune-mediated oesophagitis 105.25 13.31 25 180768 59 110408447
Arthralgia 104.95 13.31 795 179998 778837 109629669
Chest pain 104.46 13.31 294 180499 376081 110032425
Peripheral venous disease 104.02 13.31 9 180784 84108 110324398
Red blood cell sedimentation rate increased 103.69 13.31 6 180787 78296 110330210
Sarcoid-like reaction 103.69 13.31 33 180760 293 110408213
Upper respiratory tract infection 102.63 13.31 43 180750 131285 110277221
Abdominal distension 100.62 13.31 83 180710 175020 110233486
Transitional cell carcinoma metastatic 99.83 13.31 27 180766 125 110408381
Blood thyroid stimulating hormone abnormal 97.39 13.31 44 180749 1085 110407421
Intestinal perforation 97.12 13.31 144 180649 20800 110387706
Primary hypothyroidism 95.62 13.31 30 180763 253 110408253
Fluid retention 95.45 13.31 19 180774 94288 110314218
Autoimmune myocarditis 95.37 13.31 37 180756 614 110407892
Autoimmune arthritis 95.11 13.31 30 180763 258 110408248
Rash 93.82 13.31 1872 178921 819092 109589414
Rheumatoid arthritis 93.13 13.31 221 180572 299392 110109114
Large intestine perforation 92.92 13.31 125 180668 16504 110392002
Bradycardia 92.77 13.31 71 180722 155446 110253060
Autoimmune pancreatitis 92.62 13.31 39 180754 807 110407699
Lung lobectomy 92.59 13.31 28 180765 206 110408300
Malaise 92.44 13.31 1577 179216 670242 109738264
Blister 92.26 13.31 143 180650 227233 110181273
Enteritis 92.14 13.31 134 180659 19022 110389484
Gait disturbance 91.51 13.31 199 180594 278009 110130497
Vascular access complication 91.50 13.31 55 180738 2473 110406033
Coma 91.46 13.31 39 180754 117830 110290676
Influenza 90.13 13.31 86 180707 169015 110239491
Dyspepsia 89.67 13.31 108 180685 190857 110217649
Hypoaesthesia 89.00 13.31 243 180550 313980 110094526
International normalised ratio increased 88.83 13.31 17 180776 86755 110321751
Agitation 86.77 13.31 38 180755 113013 110295493
Primary adrenal insufficiency 86.24 13.31 34 180759 590 110407916
Knee arthroplasty 85.93 13.31 5 180788 64943 110343563
Therapeutic product effect incomplete 85.88 13.31 146 180647 223659 110184847
Gait inability 85.59 13.31 59 180734 136317 110272189
Cardiotoxicity 85.47 13.31 121 180672 16760 110391746
Lactic acidosis 85.38 13.31 23 180770 92788 110315718
Tremor 85.13 13.31 124 180669 202108 110206398
Amnesia 84.83 13.31 33 180760 105375 110303131
Sedation 84.70 13.31 8 180785 69675 110338831
Injection site swelling 84.13 13.31 4 180789 61786 110346720
Haematotoxicity 83.81 13.31 135 180658 20947 110387559
Cerebral infarction 83.45 13.31 229 180564 51609 110356897
Cancer pain 83.42 13.31 77 180716 6695 110401811
Adrenalitis 83.10 13.31 21 180772 70 110408436
Pericardial effusion 82.59 13.31 243 180550 56974 110351532
Pneumothorax 82.56 13.31 180 180613 35105 110373401
Hepatitis cholestatic 81.78 13.31 121 180672 17445 110391061
Autoimmune lung disease 80.63 13.31 25 180768 202 110408304
Nasal congestion 80.38 13.31 30 180763 98252 110310254
Wrong technique in product usage process 79.69 13.31 22 180771 87326 110321180
Meningitis 79.62 13.31 97 180696 11605 110396901
Dyspnoea 79.01 13.31 1304 179489 1105568 109302938
Neck pain 78.97 13.31 52 180741 123078 110285428
Alopecia 77.96 13.31 319 180474 364434 110044072
Pericarditis malignant 77.74 13.31 20 180773 73 110408433
Mixed liver injury 77.16 13.31 97 180696 11982 110396524
Plasma cell myeloma 77.10 13.31 7 180786 62929 110345577
Immune-mediated encephalopathy 76.30 13.31 20 180773 80 110408426
Metastases to central nervous system 75.97 13.31 135 180658 22682 110385824
Paraesthesia 75.95 13.31 217 180576 276304 110132202
Cardiac failure congestive 75.67 13.31 81 180712 150919 110257587
Tumour necrosis 75.48 13.31 48 180745 2388 110406118
Troponin I increased 75.06 13.31 66 180727 5386 110403120
Alanine aminotransferase increased 74.88 13.31 536 180257 183237 110225269
Swelling face 74.13 13.31 29 180764 92292 110316214
Disease progression 72.40 13.31 662 180131 243372 110165134
Organising pneumonia 71.97 13.31 102 180691 14141 110394365
Off label use 71.86 13.31 3065 177728 1497120 108911386
Heart rate increased 71.14 13.31 78 180715 143756 110264750
Nephropathy toxic 71.04 13.31 146 180647 27332 110381174
Hallucination 70.42 13.31 39 180754 101393 110307113
Lymphocytic hypophysitis 69.43 13.31 30 180763 663 110407843
Syncope 68.99 13.31 142 180651 202394 110206112
Dermatitis psoriasiform 68.80 13.31 53 180740 3591 110404915
Cardiac tamponade 67.81 13.31 88 180705 11219 110397287
Ear pain 67.75 13.31 5 180788 53221 110355285
Septic shock 67.42 13.31 465 180328 157063 110251443
Lymphangiosis carcinomatosa 67.34 13.31 45 180748 2437 110406069
Aspartate aminotransferase increased 67.21 13.31 470 180323 159466 110249040
Gastrointestinal disorder 67.08 13.31 189 180604 241763 110166743
Ileus 66.55 13.31 152 180641 30577 110377929
Radiation necrosis 66.51 13.31 31 180762 823 110407683
Gastrointestinal anastomotic leak 66.50 13.31 30 180763 737 110407769
Autoimmune haemolytic anaemia 66.14 13.31 84 180709 10483 110398023
Physical deconditioning 65.82 13.31 51 180742 3486 110405020
Nephrotic syndrome 65.43 13.31 96 180697 13735 110394771
Malignant ascites 65.25 13.31 36 180757 1374 110407132
Blood corticotrophin increased 65.18 13.31 23 180770 288 110408218
Lymphadenectomy 65.05 13.31 37 180756 1499 110407007
Feeling hot 64.75 13.31 34 180759 91072 110317434
Immune-mediated cholestasis 64.58 13.31 16 180777 48 110408458
Respiratory failure 64.30 13.31 585 180208 214747 110193759
Osteoporosis 64.23 13.31 31 180762 87121 110321385
Aggression 64.12 13.31 10 180783 59200 110349306
Pulmonary embolism 63.20 13.31 581 180212 213893 110194613
Feeling abnormal 63.00 13.31 125 180668 180586 110227920
Diabetes mellitus 62.88 13.31 325 180468 99056 110309450
Pulmonary sarcoidosis 62.71 13.31 38 180755 1734 110406772
Pulmonary ossification 62.07 13.31 16 180777 59 110408447
Cardiac dysfunction 62.05 13.31 63 180730 6160 110402346
Cytopenia 61.97 13.31 146 180647 29970 110378536
Unevaluable event 61.92 13.31 11 180782 59216 110349290
Infection 61.48 13.31 344 180449 361856 110046650
Hip arthroplasty 61.42 13.31 9 180784 55804 110352702
Malignant pleural effusion 61.32 13.31 52 180741 4041 110404465
Dermatitis 60.62 13.31 138 180655 27699 110380807
Duodenitis 60.58 13.31 75 180718 9121 110399385
Duodenal perforation 60.58 13.31 44 180749 2726 110405780
Therapeutic response decreased 60.21 13.31 42 180751 96457 110312049
Cytokine storm 58.06 13.31 34 180759 1456 110407050
Taste disorder 57.85 13.31 236 180557 65151 110343355
Polyarthritis 57.81 13.31 108 180685 18855 110389651
Ill-defined disorder 57.74 13.31 105 180688 156748 110251758
Serotonin syndrome 57.64 13.31 13 180780 59140 110349366
Mastectomy 57.62 13.31 34 180759 1477 110407029
Angioedema 57.43 13.31 46 180747 98454 110310052
Ascites 56.99 13.31 301 180492 92507 110315999
Pain in jaw 56.90 13.31 8 180785 51169 110357337
Incorrect route of product administration 56.84 13.31 17 180776 64044 110344462
Chest discomfort 56.61 13.31 125 180668 173723 110234783
Respiratory arrest 56.43 13.31 13 180780 58286 110350220
Disseminated intravascular coagulation 56.42 13.31 172 180621 41114 110367392
Morphoea 56.23 13.31 25 180768 593 110407913
Back injury 56.15 13.31 6 180787 47393 110361113
Hyperglycaemia 55.74 13.31 281 180512 84809 110323697
Multiple sclerosis relapse 55.52 13.31 8 180785 50232 110358274
Palpitations 54.75 13.31 111 180682 159101 110249405
Loss of consciousness 54.67 13.31 153 180640 196153 110212353
Sleep apnoea syndrome 53.86 13.31 3 180790 40444 110368062
Rhinorrhoea 53.78 13.31 53 180740 102613 110305893
Treatment noncompliance 53.73 13.31 26 180767 72964 110335542
Amylase increased 53.68 13.31 83 180710 12436 110396070
Adverse drug reaction 53.58 13.31 56 180737 105503 110303003
Inflammation 53.52 13.31 151 180642 193087 110215419
Paraneoplastic syndrome 53.29 13.31 31 180762 1311 110407195
Thyrotoxic crisis 52.98 13.31 36 180757 2004 110406502
Hypotension 52.96 13.31 574 180219 523275 109885231
Melanoma recurrent 52.74 13.31 20 180773 311 110408195
Seizure 52.70 13.31 185 180608 221000 110187506
Rectal perforation 52.22 13.31 28 180765 1009 110407497
Renal failure 51.97 13.31 583 180210 225991 110182515
Nephrolithiasis 51.21 13.31 22 180771 66190 110342316
Onychomadesis 51.10 13.31 7 180786 45656 110362850
Onychomycosis 50.87 13.31 3 180790 38528 110369978
Haemoglobin abnormal 50.59 13.31 68 180725 8970 110399536
Burning sensation 50.43 13.31 25 180768 69187 110339319
Endocrine toxicity 50.24 13.31 14 180779 74 110408432
X-ray abnormal 50.22 13.31 3 180790 38114 110370392
Frequent bowel movements 50.21 13.31 27 180766 71363 110337143
Leukopenia 50.02 13.31 415 180378 148376 110260130
Cardiomyopathy 49.93 13.31 144 180649 33381 110375125
Liver injury 49.92 13.31 107 180686 150306 110258200
Toxic skin eruption 49.82 13.31 127 180666 27388 110381118
Asthenia 49.72 13.31 1476 179317 687523 109720983
Visual impairment 49.46 13.31 90 180703 134338 110274168
Pyelonephritis 49.35 13.31 120 180673 25130 110383376
Accidental overdose 49.30 13.31 12 180781 51822 110356684
Pneumocystis jirovecii pneumonia 49.30 13.31 168 180625 42567 110365939
Posterior reversible encephalopathy syndrome 49.05 13.31 144 180649 33717 110374789
Renal cell carcinoma recurrent 49.01 13.31 13 180780 55 110408451
Autoimmune cholangitis 49.01 13.31 13 180780 55 110408451
Nephrectomy 48.98 13.31 38 180755 2602 110405904
Atrioventricular block complete 48.76 13.31 104 180689 19978 110388528
Swollen tongue 48.40 13.31 19 180774 60343 110348163
Paraneoplastic neurological syndrome 48.23 13.31 16 180777 164 110408342
Sopor 47.78 13.31 3 180790 36543 110371963
Dyskinesia 46.85 13.31 13 180780 51433 110357073
Hypersensitivity pneumonitis 46.58 13.31 50 180743 5215 110403291
Cataract 46.49 13.31 37 180756 79448 110329058
Psychotic disorder 46.14 13.31 13 180780 50924 110357582
Cortisol abnormal 46.06 13.31 14 180779 105 110408401
Cholecystitis acute 45.78 13.31 88 180705 15694 110392812
Joint injury 45.06 13.31 6 180787 39988 110368518
Vomiting 44.82 13.31 1140 179653 909535 109498971
Haemoglobin decreased 44.52 13.31 232 180561 248495 110160011
Axillary lymphadenectomy 44.18 13.31 13 180780 86 110408420
Autoimmune retinopathy 43.92 13.31 11 180782 35 110408471
Hepatic enzyme increased 43.62 13.31 326 180467 320566 110087940
Ophthalmoplegia 43.02 13.31 40 180753 3510 110404996
Bicytopenia 42.95 13.31 54 180739 6670 110401836
Lung opacity 42.79 13.31 72 180721 11580 110396926
Haematoma 42.79 13.31 21 180772 58455 110350051
Full blood count abnormal 42.76 13.31 19 180774 56033 110352473
Transaminases increased 42.69 13.31 211 180582 63179 110345327
Joint stiffness 42.30 13.31 29 180764 67214 110341292
Heart rate decreased 41.89 13.31 44 180749 82712 110325794
Back pain 41.82 13.31 396 180397 370600 110037906
Drug level increased 41.73 13.31 13 180780 47706 110360800
Lung adenocarcinoma recurrent 41.61 13.31 13 180780 108 110408398
Emotional distress 41.46 13.31 11 180782 44836 110363670
Aspartate aminotransferase abnormal 41.33 13.31 38 180755 3287 110405219
Retinitis 41.25 13.31 3 180790 32324 110376182
Prescribed underdose 41.15 13.31 28 180765 65146 110343360
Gamma-glutamyltransferase abnormal 41.07 13.31 23 180770 904 110407602
Neutrophil count abnormal 40.67 13.31 46 180747 5086 110403420
Basal cell carcinoma 40.19 13.31 12 180781 45258 110363248
Uveitis 40.13 13.31 101 180692 21609 110386897
Endocarditis noninfective 40.00 13.31 16 180777 289 110408217
Accidental exposure to product 39.67 13.31 16 180777 49992 110358514
Respiratory disorder 39.57 13.31 35 180758 71347 110337159
Cachexia 39.56 13.31 74 180719 12931 110395575
Device issue 39.35 13.31 5 180788 34530 110373976
Troponin abnormal 39.21 13.31 13 180780 133 110408373
Respiratory tract congestion 38.99 13.31 3 180790 30854 110377652
Microvascular coronary artery disease 38.88 13.31 17 180776 387 110408119
Leukoderma 38.86 13.31 14 180779 187 110408319
Blood corticotrophin abnormal 38.73 13.31 11 180782 63 110408443
Renal tubular disorder 38.72 13.31 54 180739 7375 110401131
Tachycardia 38.57 13.31 215 180578 226430 110182076
Gastrointestinal toxicity 38.46 13.31 67 180726 11081 110397425
Eye pain 38.19 13.31 17 180776 50082 110358424
Tumour lysis syndrome 38.12 13.31 124 180669 30677 110377829
Laryngitis 38.09 13.31 11 180782 42400 110366106
Feeding disorder 38.05 13.31 98 180695 21264 110387242
Oropharyngeal pain 37.98 13.31 105 180688 135171 110273335
Balance disorder 37.78 13.31 84 180709 116476 110292030
Apoptosis 37.68 13.31 20 180773 706 110407800
Miller Fisher syndrome 37.56 13.31 16 180777 341 110408165
Rectal haemorrhage 37.51 13.31 88 180705 119745 110288761
Dermatomyositis 37.51 13.31 41 180752 4365 110404141
Drug effective for unapproved indication 37.48 13.31 76 180717 14091 110394415
Electrocardiogram QT prolonged 37.42 13.31 76 180717 108884 110299622
Laryngopharyngitis 37.37 13.31 12 180781 110 110408396
Adrenalectomy 37.33 13.31 8 180785 9 110408497
Stomatitis 37.26 13.31 635 180158 269607 110138899
Myelitis transverse 36.99 13.31 31 180762 2370 110406136
Oesophagitis 36.81 13.31 117 180676 28598 110379908
Irritability 36.79 13.31 16 180777 47793 110360713
Blood lactate dehydrogenase abnormal 36.77 13.31 19 180774 634 110407872
Product administration error 36.62 13.31 8 180785 37209 110371297
Ketoacidosis 36.61 13.31 62 180731 10025 110398481
Throat irritation 36.58 13.31 21 180772 53531 110354975
Paraneoplastic dermatomyositis 36.38 13.31 14 180779 227 110408279
Hospitalisation 36.11 13.31 116 180677 142377 110266129
Hydronephrosis 35.99 13.31 94 180699 20571 110387935
Orbital myositis 35.94 13.31 14 180779 235 110408271
Extrapyramidal disorder 35.93 13.31 3 180790 28864 110379642
Sinus congestion 35.71 13.31 4 180789 30455 110378051
Myasthenia gravis crisis 35.60 13.31 27 180766 1787 110406719
Influenza like illness 35.46 13.31 56 180737 88356 110320150
Pulmonary resection 35.21 13.31 13 180780 187 110408319
Device dislocation 35.14 13.31 5 180788 31699 110376807
Nail disorder 35.11 13.31 26 180767 57909 110350597
Ejection fraction decreased 34.94 13.31 146 180647 40734 110367772
Vogt-Koyanagi-Harada disease 34.91 13.31 18 180775 598 110407908
Central venous catheterisation 34.90 13.31 37 180756 3805 110404701
Renal arteriosclerosis 34.65 13.31 17 180776 507 110407999
Myocardial infarction 34.46 13.31 179 180614 191904 110216602
Restlessness 34.42 13.31 25 180768 56234 110352272
Autoimmune myositis 34.23 13.31 21 180772 980 110407526
Coeliac disease 33.96 13.31 14 180779 43173 110365333
Renal tubular injury 33.83 13.31 33 180760 3075 110405431
Hepatocellular injury 33.70 13.31 168 180625 50474 110358032
Anti-glomerular basement membrane disease 33.60 13.31 12 180781 156 110408350
Scleroderma-like reaction 33.55 13.31 13 180780 215 110408291
Optic neuritis 33.38 13.31 63 180730 11084 110397422
Cardiac arrest 33.28 13.31 187 180606 196566 110211940
Platelet count abnormal 33.25 13.31 46 180747 6236 110402270
Obstructive airways disorder 33.12 13.31 17 180776 46132 110362374
Troponin T increased 33.11 13.31 38 180755 4268 110404238
Metastatic malignant melanoma 33.06 13.31 34 180759 3375 110405131
Limbic encephalitis 32.98 13.31 19 180774 789 110407717
Stress cardiomyopathy 32.92 13.31 77 180716 15729 110392777
Melanosis 32.90 13.31 10 180783 75 110408431
Glomerulonephritis rapidly progressive 32.90 13.31 28 180765 2187 110406319
Female genital tract fistula 32.81 13.31 79 180714 16440 110392066
Hallucination, visual 32.53 13.31 12 180781 39593 110368913
Autoimmune endocrine disorder 32.51 13.31 6 180787 0 110408506
Positron emission tomogram abnormal 32.47 13.31 16 180777 482 110408024
Cervix cancer metastatic 32.39 13.31 9 180784 47 110408459
Hepatitis toxic 32.31 13.31 44 180749 5877 110402629
Abdominal pain 32.11 13.31 618 180175 512371 109896135
Colitis microscopic 32.10 13.31 69 180724 13325 110395181
Vertigo 32.10 13.31 58 180735 86812 110321694
Abnormal behaviour 31.78 13.31 12 180781 39027 110369479
Radiotherapy to lung 31.73 13.31 7 180786 10 110408496
Prostate cancer 31.60 13.31 11 180782 37630 110370876
Poisoning 31.32 13.31 5 180788 29100 110379406
Mucocutaneous rash 31.30 13.31 10 180783 90 110408416
Dystonia 31.26 13.31 3 180790 25802 110382704
Chronic inflammatory demyelinating polyradiculoneuropathy 31.08 13.31 27 180766 2168 110406338
Cervix carcinoma recurrent 30.92 13.31 9 180784 57 110408449
Metastases to meninges 30.89 13.31 40 180753 5088 110403418
Viral infection 30.74 13.31 25 180768 53114 110355392
Lethargy 30.68 13.31 67 180726 93509 110314997
Heart rate irregular 30.58 13.31 9 180784 34265 110374241
Gastric stenosis 30.56 13.31 12 180781 206 110408300
Body surface area decreased 30.53 13.31 9 180784 60 110408446
Orthostatic hypotension 30.52 13.31 38 180755 66211 110342295
Cutaneous sarcoidosis 30.50 13.31 16 180777 551 110407955
Prerenal failure 30.40 13.31 37 180756 4422 110404084
Sinus disorder 30.31 13.31 8 180785 32720 110375786
Lymphadenopathy mediastinal 30.30 13.31 41 180752 5443 110403063
Cerebrovascular accident 30.28 13.31 173 180620 181111 110227395
Dysphagia 30.27 13.31 384 180409 153216 110255290
Sialoadenitis 30.26 13.31 29 180764 2644 110405862
Cough 30.16 13.31 552 180241 461089 109947417
Haematochezia 30.00 13.31 93 180700 115431 110293075
Scleroedema 29.93 13.31 11 180782 156 110408350
Product prescribing error 29.88 13.31 24 180769 51307 110357199
Thyroid function test abnormal 29.83 13.31 32 180761 3335 110405171
Blood creatine phosphokinase abnormal 29.82 13.31 17 180776 692 110407814
Cryptitis 29.78 13.31 14 180779 379 110408127
Tracheal fistula 29.78 13.31 12 180781 221 110408285
Cancer fatigue 29.68 13.31 14 180779 382 110408124
Impaired work ability 29.68 13.31 4 180789 26415 110382091
Vanishing bile duct syndrome 29.65 13.31 31 180762 3137 110405369
Hallucination, auditory 29.64 13.31 4 180789 26393 110382113
Breast cancer 29.50 13.31 13 180780 38529 110369977
Liver disorder 29.48 13.31 359 180434 141884 110266622
Eye irritation 29.45 13.31 9 180784 33443 110375063
Pancreatitis 29.38 13.31 257 180536 93276 110315230
Therapy interrupted 29.38 13.31 23 180770 49799 110358707
Haematocrit decreased 29.35 13.31 39 180754 66078 110342428
Autoimmune blistering disease 29.33 13.31 7 180786 17 110408489
Respiratory depression 29.30 13.31 8 180785 31993 110376513
Intestinal intraepithelial lymphocytes increased 29.29 13.31 12 180781 231 110408275
Blood pressure systolic increased 29.26 13.31 57 180736 82934 110325572
Tendonitis 29.18 13.31 4 180789 26079 110382427
Necrotising myositis 29.10 13.31 25 180768 1977 110406529
Metabolic acidosis 29.07 13.31 76 180717 99668 110308838
Transitional cell carcinoma recurrent 29.04 13.31 7 180786 18 110408488
Hepatic cirrhosis 28.90 13.31 41 180752 67585 110340921
Medical device site thrombosis 28.88 13.31 10 180783 118 110408388
Hepatic failure 28.86 13.31 202 180591 68537 110339969
Latent autoimmune diabetes in adults 28.83 13.31 11 180782 174 110408332
Lymphadenopathy 28.83 13.31 191 180602 63644 110344862
Cortisol increased 28.83 13.31 16 180777 618 110407888
Depressed level of consciousness 28.73 13.31 91 180702 112187 110296319
Liver abscess 28.66 13.31 48 180745 7691 110400815
Oral lichenoid reaction 28.55 13.31 11 180782 179 110408327
Rash pruritic 28.53 13.31 265 180528 97804 110310702
Gallbladder enlargement 28.46 13.31 25 180768 2037 110406469
Impaired quality of life 28.45 13.31 7 180786 30010 110378496
Breast conserving surgery 28.42 13.31 18 180775 889 110407617
Ocular myasthenia 28.35 13.31 17 180776 761 110407745
Immunodeficiency 28.33 13.31 14 180779 38824 110369682
Autoimmune uveitis 28.26 13.31 7 180786 21 110408485
Skin erosion 28.23 13.31 41 180752 5813 110402693
Delusion 28.16 13.31 3 180790 23752 110384754
Hyponatraemia 28.05 13.31 506 180287 217147 110191359
Heteroplasia 28.01 13.31 7 180786 22 110408484
Coordination abnormal 27.91 13.31 4 180789 25224 110383282
Chronic sinusitis 27.70 13.31 4 180789 25080 110383426
Infectious pleural effusion 27.68 13.31 37 180756 4854 110403652
Henoch-Schonlein purpura 27.66 13.31 32 180761 3625 110404881
Chronic obstructive pulmonary disease 27.56 13.31 89 180704 109069 110299437
Non-small cell lung cancer recurrent 27.48 13.31 11 180782 199 110408307
Pericardial effusion malignant 27.41 13.31 12 180781 274 110408232
Blood pressure systolic abnormal 27.36 13.31 4 180789 24846 110383660
Carcinoembryonic antigen increased 27.09 13.31 28 180765 2796 110405710
Diffuse uveal melanocytic proliferation 27.02 13.31 6 180787 9 110408497
Gout 26.95 13.31 13 180780 36553 110371953
Femur fracture 26.89 13.31 20 180773 44449 110364057
Necrotic lymphadenopathy 26.89 13.31 11 180782 211 110408295
N-terminal prohormone brain natriuretic peptide increased 26.83 13.31 41 180752 6080 110402426
Performance status decreased 26.82 13.31 45 180748 7221 110401285
Vision blurred 26.81 13.31 114 180679 128908 110279598
Flushing 26.72 13.31 85 180708 104651 110303855
Hip fracture 26.68 13.31 12 180781 35139 110373367
Radiotherapy to bone 26.64 13.31 6 180787 10 110408496
Bladder tamponade 26.61 13.31 16 180777 720 110407786
Polyneuropathy in malignant disease 26.56 13.31 14 180779 487 110408019
Torsade de pointes 26.42 13.31 3 180790 22597 110385909
Tumour ulceration 26.19 13.31 12 180781 306 110408200
Pulmonary hypertension 26.15 13.31 31 180762 55189 110353317
Retroperitoneal fibrosis 26.13 13.31 16 180777 744 110407762
Aplasia pure red cell 26.08 13.31 52 180741 9526 110398980
Unresponsive to stimuli 25.97 13.31 40 180753 63750 110344756
Ulcerative duodenitis 25.95 13.31 7 180786 32 110408474
Gastric perforation 25.95 13.31 36 180757 4893 110403613
Cardiac imaging procedure abnormal 25.94 13.31 6 180787 12 110408494
Drug reaction with eosinophilia and systemic symptoms 25.92 13.31 60 180733 82035 110326471
Hyperpyrexia 25.91 13.31 47 180746 8022 110400484
Cell death 25.68 13.31 39 180754 5752 110402754
Pulmonary granuloma 25.67 13.31 26 180767 2535 110405971
Chemotherapy 25.66 13.31 24 180769 2122 110406384
Agranulocytosis 25.64 13.31 181 180612 61579 110346927
Sputum discoloured 25.56 13.31 7 180786 27938 110380568
Miosis 25.49 13.31 3 180790 21980 110386526
Acquired tracheo-oesophageal fistula 25.45 13.31 10 180783 172 110408334
Systemic scleroderma 25.42 13.31 23 180770 1949 110406557
Hypervolaemia 25.37 13.31 26 180767 49434 110359072
Drug-induced liver injury 25.30 13.31 304 180489 119763 110288743
Head injury 25.18 13.31 20 180773 42997 110365509
Peripheral sensory neuropathy 25.18 13.31 72 180721 16608 110391898
Blood creatinine abnormal 25.17 13.31 39 180754 5853 110402653
Hepatitis fulminant 25.16 13.31 48 180745 8512 110399994
Panic attack 25.10 13.31 8 180785 28932 110379574
Productive cough 25.00 13.31 99 180694 114206 110294300
Thyroxine free increased 24.94 13.31 20 180773 1437 110407069
Tri-iodothyronine free decreased 24.83 13.31 13 180780 446 110408060
Gastroenteritis viral 24.75 13.31 10 180783 31216 110377290
Pulmonary imaging procedure abnormal 24.74 13.31 5 180788 3 110408503
Tumour cavitation 24.66 13.31 8 180785 76 110408430
Cancer surgery 24.65 13.31 17 180776 970 110407536
Coronary artery disease 24.62 13.31 50 180743 71640 110336866
Mental status changes 24.55 13.31 55 180738 76067 110332439
Body temperature decreased 24.50 13.31 15 180778 36920 110371586
Nervousness 24.40 13.31 15 180778 36836 110371670
Recurrent cancer 24.31 13.31 29 180764 3394 110405112
Tumour embolism 24.24 13.31 11 180782 274 110408232
Device malfunction 24.14 13.31 6 180787 25552 110382954
Malignant gastrointestinal obstruction 24.10 13.31 7 180786 44 110408462
Acquired gene mutation 24.10 13.31 26 180767 2728 110405778
Polyneuropathy 24.06 13.31 110 180683 31902 110376604
Postrenal failure 24.05 13.31 16 180777 860 110407646
Tenderness 24.04 13.31 9 180784 29428 110379078
Blood pressure abnormal 24.00 13.31 86 180707 22338 110386168
Hyperthermia 23.99 13.31 83 180710 21189 110387317
Protein urine 23.79 13.31 20 180773 1536 110406970
Oedema peripheral 23.71 13.31 386 180407 328274 110080232
Eye pruritus 23.63 13.31 12 180781 32763 110375743
Thyroxine free decreased 23.60 13.31 18 180775 1202 110407304
Gastrointestinal oedema 23.52 13.31 28 180765 3270 110405236
Lip swelling 23.40 13.31 29 180764 50638 110357868
Ventricular fibrillation 23.21 13.31 20 180773 41293 110367213
Idiopathic interstitial pneumonia 23.16 13.31 15 180778 770 110407736
Blood creatine phosphokinase increased 23.06 13.31 201 180592 72876 110335630
Autoimmune dermatitis 22.98 13.31 10 180783 225 110408281
Gastric disorder 22.90 13.31 13 180780 33344 110375162
Liver ablation 22.89 13.31 6 180787 24 110408482
CSF protein abnormal 22.89 13.31 6 180787 24 110408482
Cardiac murmur 22.84 13.31 6 180787 24622 110383884
Localised infection 22.80 13.31 22 180771 43026 110365480
Tinnitus 22.74 13.31 40 180753 60500 110348006
Coronavirus infection 22.68 13.31 49 180744 9496 110399010
Urinary bladder rupture 22.58 13.31 9 180784 161 110408345
Eye swelling 22.51 13.31 13 180780 33035 110375471
Thyroxine increased 22.36 13.31 16 180777 968 110407538
Cardiac disorder 22.32 13.31 58 180735 76222 110332284
Peritonitis 22.28 13.31 109 180684 32498 110376008
Dermatitis atopic 22.26 13.31 7 180786 25534 110382972
Illness 22.16 13.31 65 180728 82106 110326400
Probiotic therapy 22.13 13.31 9 180784 170 110408336
Oxygen saturation decreased 22.02 13.31 158 180635 156824 110251682
Myopathy 22.00 13.31 90 180703 24870 110383636
Thyroiditis subacute 21.97 13.31 12 180781 449 110408057
Extremity necrosis 21.88 13.31 29 180764 3773 110404733
Autoimmune neuropathy 21.86 13.31 8 180785 112 110408394
Hypermutation 21.86 13.31 8 180785 112 110408394
Visceral venous thrombosis 21.81 13.31 6 180787 30 110408476
Intervertebral disc protrusion 21.74 13.31 9 180784 27689 110380817
Ureteritis 21.72 13.31 10 180783 258 110408248
Capillary leak syndrome 21.69 13.31 33 180760 4875 110403631
Infected neoplasm 21.68 13.31 13 180780 582 110407924
Imaging procedure abnormal 21.67 13.31 4 180789 0 110408506
Gastrointestinal tube removal 21.67 13.31 4 180789 0 110408506
Body temperature increased 21.61 13.31 35 180758 54678 110353828
Thyroid hormones increased 21.58 13.31 13 180780 587 110407919
Rash papular 21.54 13.31 96 180697 27543 110380963
Oesophagobronchial fistula 21.51 13.31 10 180783 264 110408242
Ischaemic stroke 21.46 13.31 128 180665 41135 110367371
Periarticular thenar erythema with onycholysis 21.44 13.31 7 180786 68 110408438
Lupus-like syndrome 21.43 13.31 21 180772 40771 110367735
Biliary dilatation 21.41 13.31 28 180765 3597 110404909
Autoimmune disorder 21.37 13.31 47 180746 65436 110343070
Microvillous inclusion disease 21.33 13.31 10 180783 269 110408237
Skin haemorrhage 21.29 13.31 7 180786 24820 110383686
Pulmonary artery thrombosis 21.27 13.31 19 180774 1583 110406923
Disorientation 21.24 13.31 53 180740 70618 110337888
Biliary cyst 21.18 13.31 8 180785 123 110408383
Lung abscess 21.17 13.31 33 180760 4979 110403527
Hypermetabolism 21.13 13.31 13 180780 610 110407896
Post procedural oedema 21.12 13.31 8 180785 124 110408382
Duodenal ulcer 21.02 13.31 75 180718 19439 110389067
Acute polyneuropathy 21.02 13.31 14 180779 754 110407752
Oesophageal fistula 20.99 13.31 12 180781 491 110408015
Hypoglycaemia 20.93 13.31 108 180685 115996 110292510
Tri-iodothyronine decreased 20.86 13.31 11 180782 383 110408123
BRCA1 gene mutation 20.82 13.31 7 180786 75 110408431
Tumour perforation 20.71 13.31 13 180780 632 110407874
Cutaneous lupus erythematosus 20.69 13.31 27 180766 3461 110405045
Macular degeneration 20.62 13.31 5 180788 21654 110386852
SJS-TEN overlap 20.59 13.31 20 180773 1854 110406652
Hyperlipidaemia 20.57 13.31 17 180776 35831 110372675
Paraesthesia oral 20.55 13.31 15 180778 33656 110374850
Hyperlipasaemia 20.45 13.31 18 180775 1471 110407035
Tumour rupture 20.44 13.31 13 180780 647 110407859
Hypogammaglobulinaemia 20.40 13.31 4 180789 20072 110388434
Gastroenteritis radiation 20.37 13.31 14 180779 794 110407712
Throat tightness 20.33 13.31 15 180778 33474 110375032
Pancreatic failure 20.20 13.31 22 180771 2332 110406174
Radiotherapy to lymph nodes 20.18 13.31 5 180788 15 110408491
Acute coronary syndrome 20.11 13.31 83 180710 23029 110385477
Hepatitis acute 20.11 13.31 72 180721 18694 110389812
Rheumatic disorder 20.07 13.31 27 180766 3564 110404942
Ankle fracture 20.04 13.31 4 180789 19815 110388691
Cholestatic liver injury 20.03 13.31 40 180753 7336 110401170
Ulcer haemorrhage 20.00 13.31 6 180787 22565 110385941
Mixed deafness 19.94 13.31 5 180788 16 110408490
Breast tumour excision 19.94 13.31 5 180788 16 110408490
Diffuse panbronchiolitis 19.74 13.31 6 180787 45 110408461
Amputation stump pain 19.74 13.31 6 180787 45 110408461
Activated partial thromboplastin time prolonged 19.73 13.31 6 180787 22362 110386144
Presyncope 19.57 13.31 31 180762 48856 110359650
Tooth infection 19.52 13.31 6 180787 22210 110386296
Inflammatory marker increased 19.51 13.31 60 180733 14409 110394097
Gastritis haemorrhagic 19.51 13.31 25 180768 3148 110405358
Altered state of consciousness 19.50 13.31 161 180632 57465 110351041
IIIrd nerve paralysis 19.41 13.31 17 180776 1380 110407126
White blood cell count abnormal 19.40 13.31 38 180755 6871 110401635
Iron deficiency anaemia 19.34 13.31 14 180779 31545 110376961
Neutrophil toxic granulation present 19.31 13.31 9 180784 239 110408267
Lymph node fibrosis 19.28 13.31 5 180788 19 110408487
Limb discomfort 19.28 13.31 23 180770 40831 110367675
Gastritis 19.24 13.31 152 180641 53547 110354959
Aptyalism 19.18 13.31 14 180779 874 110407632
Biliary tract disorder 19.15 13.31 19 180774 1807 110406699
Infusion site reaction 19.11 13.31 3 180790 17679 110390827
Respiratory tract infection 19.06 13.31 57 180736 71560 110336946
Limb injury 19.06 13.31 20 180773 37616 110370890
Pneumonia aspiration 19.05 13.31 210 180583 81023 110327483
Cytomegalovirus enterocolitis 19.03 13.31 21 180772 2260 110406246
Middle insomnia 19.01 13.31 5 180788 20497 110388009
Schizophrenia 18.99 13.31 6 180787 21820 110386686
Benign mediastinal neoplasm 18.98 13.31 6 180787 52 110408454
Rash maculovesicular 18.98 13.31 6 180787 52 110408454
Myalgia 18.97 13.31 487 180306 221894 110186612
Thyroxine decreased 18.74 13.31 14 180779 906 110407600
Muscle twitching 18.71 13.31 13 180780 29922 110378584
Hepatitis viral 18.61 13.31 17 180776 1458 110407048
Hiatus hernia 18.61 13.31 11 180782 27595 110380911
Solid organ transplant rejection 18.59 13.31 6 180787 56 110408450
Skin squamous cell carcinoma recurrent 18.57 13.31 7 180786 107 110408399
Acute promyelocytic leukaemia 18.55 13.31 19 180774 1877 110406629
Sensory loss 18.49 13.31 6 180787 21451 110387055
Ureteric dilatation 18.45 13.31 9 180784 265 110408241
Intentional dose omission 18.42 13.31 5 180788 20075 110388431
Respiratory rate increased 18.36 13.31 9 180784 25074 110383432
Cardiac failure acute 18.29 13.31 83 180710 23995 110384511
Pharyngeal inflammation 18.28 13.31 18 180775 1696 110406810
Food allergy 18.24 13.31 5 180788 19943 110388563
Tumour marker increased 18.23 13.31 31 180762 5029 110403477
Axonal and demyelinating polyneuropathy 18.22 13.31 6 180787 60 110408446
Enanthema 18.22 13.31 15 180778 1119 110407387
Autoimmune encephalopathy 18.18 13.31 8 180785 185 110408321
Intestinal obstruction 18.17 13.31 149 180644 53078 110355428
Mediastinal cyst 18.13 13.31 6 180787 61 110408445
Peripheral sensorimotor neuropathy 18.12 13.31 27 180766 3916 110404590
Sepsis 18.10 13.31 680 180113 326666 110081840
Gastroduodenal ulcer 18.07 13.31 14 180779 957 110407549
Chronic gastritis 17.99 13.31 32 180761 5379 110403127
Arthritis 17.97 13.31 181 180612 167405 110241101
Rales 17.92 13.31 9 180784 24730 110383776
Lipase increased 17.80 13.31 69 180724 18603 110389903
Right ventricular ejection fraction decreased 17.79 13.31 6 180787 65 110408441
Restless legs syndrome 17.78 13.31 9 180784 24617 110383889
Parkinsonism 17.76 13.31 7 180786 22180 110386326
Tachypnoea 17.73 13.31 23 180770 39372 110369134
Mitral valve incompetence 17.69 13.31 17 180776 33312 110375194
Staphylococcal infection 17.67 13.31 57 180736 69887 110338619
Tumour pain 17.65 13.31 23 180770 2944 110405562
Epilepsy 17.62 13.31 94 180699 100115 110308391
Roseolovirus test positive 17.59 13.31 9 180784 294 110408212
Ulcer 17.58 13.31 27 180766 43089 110365417
Drug use disorder 17.55 13.31 4 180789 18070 110390436
Liver scan abnormal 17.55 13.31 6 180787 68 110408438
Lower gastrointestinal perforation 17.55 13.31 6 180787 68 110408438
Thyroid hormones decreased 17.42 13.31 12 180781 683 110407823
Metastases to adrenals 17.41 13.31 17 180776 1586 110406920
Hypereosinophilic syndrome 17.40 13.31 13 180780 841 110407665
Carbohydrate antigen 19-9 increased 17.34 13.31 11 180782 545 110407961
Myoclonus 17.32 13.31 17 180776 32981 110375525
Vaginal discharge 17.32 13.31 4 180789 17904 110390602
Jejunal perforation 17.28 13.31 10 180783 419 110408087
Hyperamylasaemia 17.25 13.31 15 180778 1206 110407300
Hepatic cyst infection 17.25 13.31 8 180785 210 110408296
Tissue infiltration 17.18 13.31 14 180779 1029 110407477
Red blood cell count decreased 17.17 13.31 53 180740 65870 110342636
Blood pressure diastolic decreased 17.15 13.31 20 180773 35865 110372641
Metastases to lung 17.14 13.31 79 180714 22984 110385522
Blood bilirubin abnormal 17.13 13.31 18 180775 1832 110406674
Mental disorder 17.09 13.31 23 180770 38768 110369738
Oesophageal carcinoma recurrent 17.09 13.31 6 180787 74 110408432
Embolism arterial 17.06 13.31 18 180775 1841 110406665
Trichoglossia 17.06 13.31 13 180780 867 110407639
Sudden death 16.99 13.31 82 180711 24313 110384193
Keratoacanthoma 16.94 13.31 16 180777 1432 110407074
Mean cell volume abnormal 16.91 13.31 12 180781 717 110407789
Serous retinal detachment 16.80 13.31 17 180776 1655 110406851
Procedural pain 16.80 13.31 20 180773 35545 110372961
Herpes simplex reactivation 16.76 13.31 16 180777 1452 110407054
Paralysis recurrent laryngeal nerve 16.71 13.31 8 180785 226 110408280
Mood altered 16.69 13.31 7 180786 21368 110387138
Hepatectomy 16.67 13.31 9 180784 329 110408177
Hepatic rupture 16.66 13.31 7 180786 144 110408362
Ocular hyperaemia 16.61 13.31 24 180769 39262 110369244
Glaucoma 16.60 13.31 8 180785 22509 110385997
Hand dermatitis 16.59 13.31 12 180781 739 110407767
AST/ALT ratio abnormal 16.57 13.31 7 180786 146 110408360
Blood alkaline phosphatase abnormal 16.57 13.31 15 180778 1272 110407234
Flatulence 16.55 13.31 38 180755 52111 110356395
Allergic colitis 16.51 13.31 5 180788 37 110408469
Generalised tonic-clonic seizure 16.44 13.31 41 180752 54639 110353867
Papilloedema 16.43 13.31 37 180756 7372 110401134
Prothrombin time prolonged 16.41 13.31 4 180789 17257 110391249
Cytokine abnormal 16.40 13.31 4 180789 11 110408495
Bronchogram abnormal 16.40 13.31 4 180789 11 110408495
HTLV-1 test positive 16.40 13.31 4 180789 11 110408495
Polyglandular autoimmune syndrome type II 16.39 13.31 5 180788 38 110408468
Vitamin D deficiency 16.32 13.31 5 180788 18547 110389959
Endocrine disorder 16.27 13.31 14 180779 1110 110407396
Computerised tomogram kidney abnormal 16.25 13.31 3 180790 0 110408506
Lymphoid tissue operation 16.25 13.31 3 180790 0 110408506
Aortic perforation 16.25 13.31 3 180790 0 110408506
Allergic bronchopulmonary mycosis 16.25 13.31 3 180790 0 110408506
Gamma radiation therapy 16.25 13.31 3 180790 0 110408506
Squamous cell carcinoma antigen increased 16.25 13.31 3 180790 0 110408506
Renal vein embolism 16.25 13.31 3 180790 0 110408506
Tracheostomy 16.22 13.31 16 180777 1511 110406995
Cellulitis 16.18 13.31 130 180663 125886 110282620
Oligodipsia 16.17 13.31 5 180788 40 110408466
Tri-iodothyronine abnormal 16.15 13.31 4 180789 12 110408494
Ulcerative gastritis 16.15 13.31 7 180786 156 110408350
Back disorder 16.10 13.31 7 180786 20915 110387591
Ankylosing spondylitis 16.10 13.31 3 180790 15609 110392897
Bacterial prostatitis 16.08 13.31 6 180787 89 110408417
Oesophageal-pulmonary fistula 16.06 13.31 5 180788 41 110408465
Adrenomegaly 16.03 13.31 10 180783 481 110408025
Mania 15.94 13.31 7 180786 20789 110387717
Myxoedema 15.93 13.31 8 180785 251 110408255
Neuromyopathy 15.93 13.31 17 180776 1762 110406744
Vascular access site complication 15.91 13.31 4 180789 13 110408493
Supportive care 15.91 13.31 4 180789 13 110408493
Bacterial diarrhoea 15.91 13.31 9 180784 361 110408145
Drug tolerance decreased 15.88 13.31 13 180780 27527 110380979
Adverse event 15.83 13.31 258 180535 108551 110299955
Non-small cell lung cancer 15.82 13.31 38 180755 7897 110400609
Haemolytic anaemia 15.80 13.31 72 180721 20848 110387658
Breast cancer recurrent 15.80 13.31 25 180768 3821 110404685
Rash morbilliform 15.77 13.31 38 180755 7913 110400593
Neurofibrosarcoma 15.68 13.31 8 180785 260 110408246
Arterial occlusive disease 15.66 13.31 3 180790 15305 110393201
Gastrointestinal haemorrhage 15.65 13.31 184 180609 165334 110243172
Therapy non-responder 15.60 13.31 173 180620 157134 110251372
Product storage error 15.60 13.31 8 180785 21720 110386786
Eyelid sensory disorder 15.55 13.31 6 180787 98 110408408
Large intestine infection 15.50 13.31 27 180766 4465 110404041
Radiotherapy to mediastinum 15.46 13.31 4 180789 15 110408491
Drug tolerance 15.46 13.31 4 180789 16581 110391925
Radiation associated pain 15.45 13.31 8 180785 268 110408238
Cyst 15.34 13.31 4 180789 16492 110392014
Disturbance in attention 15.33 13.31 51 180742 61944 110346562
Keratitis 15.31 13.31 29 180764 5115 110403391
Hospice care 15.24 13.31 50 180743 12423 110396083
Secretion discharge 15.22 13.31 7 180786 20237 110388269
Pneumonitis chemical 15.21 13.31 11 180782 677 110407829
Acute motor-sensory axonal neuropathy 15.19 13.31 10 180783 528 110407978
Haemodialysis 15.19 13.31 5 180788 17714 110390792
Unmasking of previously unidentified disease 15.18 13.31 21 180772 2847 110405659
Gastrointestinal stenosis 15.17 13.31 9 180784 395 110408111
Blood phosphorus increased 15.12 13.31 4 180789 16336 110392170
Polymyositis 15.09 13.31 24 180769 3684 110404822
Disease recurrence 15.04 13.31 50 180743 60734 110347772
Blood pressure fluctuation 15.00 13.31 67 180726 74757 110333749
IgA nephropathy 14.97 13.31 22 180771 3151 110405355
Renal cancer recurrent 14.97 13.31 6 180787 109 110408397
Biliary obstruction 14.92 13.31 30 180763 5528 110402978
Cholangitis acute 14.91 13.31 17 180776 1896 110406610
Paraneoplastic pemphigus 14.91 13.31 7 180786 189 110408317
Alopecia scarring 14.88 13.31 7 180786 190 110408316
Osteonecrosis 14.87 13.31 20 180773 33721 110374785
Kidney infection 14.86 13.31 12 180781 25587 110382919
Vascular purpura 14.79 13.31 24 180769 3747 110404759
Aortic thrombosis 14.70 13.31 18 180775 2165 110406341
EGFR gene mutation 14.66 13.31 10 180783 560 110407946
Breath sounds abnormal 14.64 13.31 12 180781 25392 110383114
Dyslipidaemia 14.60 13.31 4 180789 15961 110392545
Flagellate dermatitis 14.58 13.31 8 180785 302 110408204
Renal tubular acidosis 14.56 13.31 27 180766 4688 110403818
Skin depigmentation 14.56 13.31 14 180779 1282 110407224
Eye infection 14.53 13.31 3 180790 14515 110393991
Paratracheal lymphadenopathy 14.51 13.31 7 180786 201 110408305
Glomerulonephritis 14.49 13.31 27 180766 4703 110403803
Upper-airway cough syndrome 14.45 13.31 4 180789 15853 110392653
Pulmonary fistula 14.39 13.31 6 180787 121 110408385
Wrist fracture 14.39 13.31 3 180790 14414 110394092
Gastroenteritis Escherichia coli 14.36 13.31 14 180779 1303 110407203
Pleurodesis 14.36 13.31 5 180788 60 110408446
Oral herpes 14.33 13.31 23 180770 36057 110372449
Decreased activity 14.33 13.31 45 180748 10929 110397577
Antinuclear antibody 14.31 13.31 9 180784 439 110408067
Coombs negative haemolytic anaemia 14.29 13.31 10 180783 584 110407922
Breast necrosis 14.26 13.31 6 180787 124 110408382
Bronchostenosis 14.22 13.31 12 180781 926 110407580
Superior vena cava stenosis 14.18 13.31 3 180790 3 110408503
Pharyngeal erosion 14.18 13.31 3 180790 3 110408503
Radiotherapy to adrenal gland 14.18 13.31 3 180790 3 110408503
Tumour thrombosis 14.11 13.31 8 180785 322 110408184
Interleukin-2 receptor increased 14.07 13.31 8 180785 324 110408182
Pneumatosis intestinalis 14.04 13.31 38 180755 8491 110400015
Perforation 13.96 13.31 16 180777 1794 110406712
Cystitis 13.93 13.31 58 180735 65978 110342528
Pancreatectomy 13.93 13.31 4 180789 24 110408482
Inappropriate antidiuretic hormone secretion 13.93 13.31 99 180694 33752 110374754
Rib fracture 13.91 13.31 21 180772 33749 110374757
Enterococcal infection 13.89 13.31 8 180785 20358 110388148
Therapeutic response increased 13.88 13.31 10 180783 612 110407894
End stage renal disease 13.86 13.31 9 180784 21464 110387042
Nephrostomy 13.85 13.31 8 180785 334 110408172
Pneumoperitoneum 13.82 13.31 24 180769 3960 110404546
Achromotrichia acquired 13.79 13.31 4 180789 25 110408481
Facial pain 13.74 13.31 4 180789 15335 110393171
Enterocolitis haemorrhagic 13.68 13.31 19 180774 2585 110405921
Interleukin level increased 13.65 13.31 15 180778 1606 110406900
Head discomfort 13.63 13.31 7 180786 18993 110389513
Angina pectoris 13.59 13.31 54 180739 62241 110346265
Autoimmune anaemia 13.53 13.31 4 180789 27 110408479
Bone disorder 13.52 13.31 9 180784 21183 110387323
Tracheal stenosis 13.47 13.31 10 180783 641 110407865
Pelvic abscess 13.44 13.31 19 180774 2627 110405879
Aortic embolus 13.41 13.31 5 180788 74 110408432
Oedema 13.40 13.31 252 180541 209724 110198782
Heavy menstrual bleeding 13.37 13.31 5 180788 16360 110392146
Hepatic calcification 13.36 13.31 8 180785 357 110408149
Thyroid gland injury 13.35 13.31 5 180788 75 110408431
Primary biliary cholangitis 13.32 13.31 14 180779 1425 110407081
Gallbladder disorder 13.32 13.31 9 180784 21020 110387486

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FF02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D000082082 Immune Checkpoint Inhibitors
MeSH PA D000970 Antineoplastic Agents
FDA MoA N0000191259 Programmed Death Receptor-1-directed Antibody Interactions
FDA EPC N0000191260 Programmed Death Receptor-1 Blocking Antibody

Related Drugs by ATC class:

L01FF PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors 11 drugs
atezolizumabavelumabcemiplimabdostarlimabdurvalumabnivolumabretifanlimabserplulimabsugemalimabtislelizumabtoripalimab

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Unresectable urothelial carcinoma indication 27090000 DOID:2671
Non-small cell lung cancer indication 254637007 DOID:3908
Endometrial carcinoma progressing after chemotherapy indication 254878006 DOID:2871
Malignant tumor of head and/or neck indication 255056009
Squamous cell carcinoma of esophagus indication 276804009 DOID:3748
Advanced or recurrent cervical cancer indication 363354003 DOID:4362
Metastatic malignant melanoma indication 443493003
Primary mediastinal large B-cell lymphoma indication 444910004
Metastatic renal cell carcinoma indication 702392008
Triple negative breast neoplasms indication 706970001
Microsatellite instability-high colorectal cancer indication 737058005
Classical Hodgkin lymphoma indication 762690000
HER2-negative breast cancer indication 767444009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Programmed cell death protein 1 Membrane receptor ANTIBODY BINDING Kd 10 IUPHAR DRUG LABEL

External reference:

IDSource
D10574 KEGG_DRUG
4033703 VUID
N0000191088 NUI
4033703 VANDF
CHEMBL3137343 ChEMBL_ID
C582435 MESH_SUPPLEMENTAL_RECORD_UI
7499 IUPHAR_LIGAND_ID
DB09037 DRUGBANK_ID
1547545 RXNORM
228586 MMSL
30533 MMSL
d08287 MMSL
015666 NDDF
716125002 SNOMEDCT_US
763541003 SNOMEDCT_US
C3658706 UMLSCUI
9798 INN_ID
166078561 PUBCHEM_CID
DPT0O3T46P UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
KEYTRUDA HUMAN PRESCRIPTION DRUG LABEL 1 0006-3026 INJECTION, SOLUTION 25 mg INTRAVENOUS BLA 30 sections
KEYTRUDA HUMAN PRESCRIPTION DRUG LABEL 1 0006-3029 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS BLA 30 sections
KEYTRUDA QLEX HUMAN PRESCRIPTION DRUG LABEL 2 0006-3083 INJECTION, SOLUTION 165 mg SUBCUTANEOUS BLA 30 sections
KEYTRUDA QLEX HUMAN PRESCRIPTION DRUG LABEL 2 0006-3083 INJECTION, SOLUTION 165 mg SUBCUTANEOUS BLA 30 sections
KEYTRUDA QLEX HUMAN PRESCRIPTION DRUG LABEL 2 0006-5083 INJECTION, SOLUTION 165 mg SUBCUTANEOUS BLA 30 sections
KEYTRUDA QLEX HUMAN PRESCRIPTION DRUG LABEL 2 0006-5083 INJECTION, SOLUTION 165 mg SUBCUTANEOUS BLA 30 sections