anagliptin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| dipeptidyl aminopeptidase-IV inhibitors | 4896 | 739366-20-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
anagliptin hydrochloride salt is the active compound
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| fu (Fraction unbound in plasma) | 0.77 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 28, 2012 | PMDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D054873 | Dipeptidyl-Peptidase IV Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007004 | Hypoglycemic Agents |
| MeSH PA | D011480 | Protease Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetes mellitus type 2 | indication | 44054006 | DOID:9352 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.32 | acidic |
| pKa2 | 5.05 | Basic |
| pKa3 | 4.34 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | Enzyme | INHIBITOR | IC50 | 8.42 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Prolyl endopeptidase FAP | Enzyme | IC50 | 4.14 | CHEMBL | |||||
| Dipeptidyl peptidase 8 | Enzyme | IC50 | 7.17 | SCIENTIFIC LITERATURE | |||||
| Dipeptidyl peptidase 9 | Enzyme | IC50 | 7.22 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| K726J96838 | UNII |
| D09780 | KEGG_DRUG |
| C3272640 | UMLSCUI |
| CHEBI:136043 | CHEBI |
| SKK | PDB_CHEM_ID |
| CHEMBL1929396 | ChEMBL_ID |
| 44513473 | PUBCHEM_CID |
| DB12417 | DRUGBANK_ID |
| CHEMBL1929387 | ChEMBL_ID |
| 9246 | INN_ID |
| C583175 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11582 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
None