Stem definition | Drug id | CAS RN |
---|---|---|
tricyclic compounds | 489 | 298-46-4 |
Dose | Unit | Route |
---|---|---|
1 | g | O |
1 | g | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.11 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 113.00 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 70 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
fu (Fraction unbound in plasma) | 0.29 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Date | Agency | Company | Orphan |
---|---|---|---|
March 11, 1968 | FDA | NOVARTIS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1358.07 | 10.78 | 1241 | 83606 | 131393 | 63272782 |
Drug reaction with eosinophilia and systemic symptoms | 957.04 | 10.78 | 584 | 84263 | 33252 | 63370923 |
Toxicity to various agents | 755.31 | 10.78 | 1255 | 83592 | 245995 | 63158180 |
Sedation | 663.43 | 10.78 | 490 | 84357 | 38319 | 63365856 |
Cognitive disorder | 642.87 | 10.78 | 559 | 84288 | 55256 | 63348919 |
Sedation complication | 640.39 | 10.78 | 330 | 84517 | 13492 | 63390683 |
Creatinine renal clearance decreased | 600.02 | 10.78 | 334 | 84513 | 15974 | 63388201 |
Balance disorder | 573.13 | 10.78 | 633 | 84214 | 83789 | 63320386 |
Abortion spontaneous | 572.56 | 10.78 | 487 | 84360 | 46708 | 63357467 |
Orthostatic hypotension | 548.18 | 10.78 | 425 | 84422 | 35735 | 63368440 |
Depressed level of consciousness | 533.31 | 10.78 | 528 | 84319 | 61550 | 63342625 |
Drug interaction | 531.19 | 10.78 | 1032 | 83815 | 228099 | 63176076 |
Blood calcium decreased | 495.27 | 10.78 | 353 | 84494 | 26098 | 63378077 |
Generalised tonic-clonic seizure | 454.98 | 10.78 | 348 | 84499 | 28668 | 63375507 |
Epilepsy | 447.38 | 10.78 | 335 | 84512 | 26730 | 63377445 |
Status epilepticus | 387.66 | 10.78 | 246 | 84601 | 14987 | 63389188 |
Anticonvulsant drug level increased | 371.80 | 10.78 | 120 | 84727 | 1397 | 63402778 |
Stevens-Johnson syndrome | 368.85 | 10.78 | 289 | 84558 | 24661 | 63379514 |
Hyponatraemia | 354.08 | 10.78 | 578 | 84269 | 111322 | 63292853 |
Psychotic disorder | 290.75 | 10.78 | 255 | 84592 | 25457 | 63378718 |
Ataxia | 277.97 | 10.78 | 200 | 84647 | 14995 | 63389180 |
Overdose | 271.74 | 10.78 | 523 | 84324 | 114555 | 63289620 |
Joint swelling | 257.50 | 10.78 | 61 | 84786 | 327605 | 63076570 |
Diarrhoea | 236.83 | 10.78 | 370 | 84477 | 714996 | 62689179 |
Synovitis | 233.89 | 10.78 | 3 | 84844 | 186915 | 63217260 |
Schizophrenia | 231.70 | 10.78 | 152 | 84695 | 9800 | 63394375 |
Arthralgia | 231.16 | 10.78 | 253 | 84594 | 569457 | 62834718 |
Rheumatoid arthritis | 229.87 | 10.78 | 33 | 84814 | 253786 | 63150389 |
Infusion related reaction | 229.29 | 10.78 | 29 | 84818 | 245492 | 63158683 |
Somnolence | 228.72 | 10.78 | 638 | 84209 | 178047 | 63226128 |
Contraindicated product administered | 226.04 | 10.78 | 17 | 84830 | 217631 | 63186544 |
Coma | 223.41 | 10.78 | 347 | 84500 | 64017 | 63340158 |
Drug level increased | 220.76 | 10.78 | 207 | 84640 | 22529 | 63381646 |
Petit mal epilepsy | 218.34 | 10.78 | 105 | 84742 | 3689 | 63400486 |
Suicide attempt | 215.04 | 10.78 | 331 | 84516 | 60587 | 63343588 |
Pemphigus | 213.97 | 10.78 | 7 | 84840 | 183719 | 63220456 |
Nystagmus | 203.43 | 10.78 | 118 | 84729 | 6102 | 63398073 |
Hand deformity | 197.57 | 10.78 | 3 | 84844 | 159454 | 63244721 |
Jaundice cholestatic | 195.65 | 10.78 | 122 | 84725 | 7202 | 63396973 |
Alopecia | 195.20 | 10.78 | 104 | 84743 | 337432 | 63066743 |
Peripheral swelling | 190.98 | 10.78 | 59 | 84788 | 265883 | 63138292 |
Diplopia | 187.43 | 10.78 | 193 | 84654 | 23535 | 63380640 |
Dyspnoea | 186.26 | 10.78 | 378 | 84469 | 660935 | 62743240 |
Swelling | 185.72 | 10.78 | 68 | 84779 | 275310 | 63128865 |
Fall | 182.54 | 10.78 | 1017 | 83830 | 391317 | 63012858 |
Exposure during pregnancy | 182.12 | 10.78 | 538 | 84309 | 155009 | 63249166 |
Partial seizures | 178.35 | 10.78 | 106 | 84741 | 5736 | 63398439 |
Abdominal discomfort | 178.12 | 10.78 | 104 | 84743 | 320781 | 63083394 |
Stillbirth | 171.69 | 10.78 | 109 | 84738 | 6641 | 63397534 |
Glossodynia | 167.26 | 10.78 | 21 | 84826 | 178855 | 63225320 |
Arthropathy | 165.15 | 10.78 | 54 | 84793 | 234738 | 63169437 |
Wound | 163.27 | 10.78 | 15 | 84832 | 163248 | 63240927 |
Systemic lupus erythematosus | 161.82 | 10.78 | 40 | 84807 | 208878 | 63195297 |
Fatigue | 161.58 | 10.78 | 627 | 84220 | 887401 | 62516774 |
Focal dyscognitive seizures | 156.54 | 10.78 | 77 | 84770 | 2844 | 63401331 |
Sinusitis | 156.15 | 10.78 | 54 | 84793 | 226599 | 63177576 |
Intentional overdose | 154.50 | 10.78 | 320 | 84527 | 73832 | 63330343 |
Drug eruption | 150.95 | 10.78 | 189 | 84658 | 28505 | 63375670 |
Pericarditis | 149.75 | 10.78 | 6 | 84841 | 131573 | 63272602 |
Drug intolerance | 148.59 | 10.78 | 117 | 84730 | 308544 | 63095631 |
Gamma-glutamyltransferase increased | 147.80 | 10.78 | 204 | 84643 | 33827 | 63370348 |
Aggression | 146.94 | 10.78 | 169 | 84678 | 23329 | 63380846 |
Hypotension | 136.24 | 10.78 | 721 | 84126 | 271883 | 63132292 |
Maternal exposure during pregnancy | 135.64 | 10.78 | 618 | 84229 | 219444 | 63184731 |
Drug level decreased | 135.22 | 10.78 | 100 | 84747 | 7819 | 63396356 |
Myoclonic epilepsy | 135.22 | 10.78 | 54 | 84793 | 1200 | 63402975 |
Toxic epidermal necrolysis | 135.07 | 10.78 | 168 | 84679 | 25166 | 63379009 |
Electroencephalogram abnormal | 134.44 | 10.78 | 75 | 84772 | 3597 | 63400578 |
Inappropriate antidiuretic hormone secretion | 131.67 | 10.78 | 131 | 84716 | 15331 | 63388844 |
Dysarthria | 124.71 | 10.78 | 213 | 84634 | 42498 | 63361677 |
Discomfort | 123.97 | 10.78 | 35 | 84812 | 167339 | 63236836 |
Trigeminal neuralgia | 123.75 | 10.78 | 70 | 84777 | 3449 | 63400726 |
Altered state of consciousness | 119.85 | 10.78 | 158 | 84689 | 25072 | 63379103 |
Multiple-drug resistance | 118 | 10.78 | 78 | 84769 | 5092 | 63399083 |
Rash maculo-papular | 117.73 | 10.78 | 177 | 84670 | 31719 | 63372456 |
Drug abuse | 117.39 | 10.78 | 283 | 84564 | 72235 | 63331940 |
Loss of consciousness | 116.41 | 10.78 | 385 | 84462 | 117736 | 63286439 |
Therapeutic product effect decreased | 115.31 | 10.78 | 57 | 84790 | 193130 | 63211045 |
Anticonvulsant drug level above therapeutic | 113.91 | 10.78 | 38 | 84809 | 494 | 63403681 |
Product use issue | 113.30 | 10.78 | 78 | 84769 | 220442 | 63183733 |
Completed suicide | 112.19 | 10.78 | 438 | 84409 | 145235 | 63258940 |
Mobility decreased | 106.37 | 10.78 | 380 | 84467 | 120779 | 63283396 |
Sopor | 104.04 | 10.78 | 138 | 84709 | 22026 | 63382149 |
Erythema multiforme | 101.42 | 10.78 | 94 | 84753 | 10075 | 63394100 |
Hypersensitivity | 100.64 | 10.78 | 147 | 84700 | 292538 | 63111637 |
Infection | 100.33 | 10.78 | 95 | 84752 | 229078 | 63175097 |
Rheumatoid factor positive | 98.99 | 10.78 | 3 | 84844 | 84403 | 63319772 |
Abortion induced | 98.92 | 10.78 | 93 | 84754 | 10149 | 63394026 |
Treatment failure | 97.54 | 10.78 | 74 | 84773 | 198969 | 63205206 |
Drug resistance | 97.37 | 10.78 | 136 | 84711 | 22797 | 63381378 |
Febrile neutropenia | 97.03 | 10.78 | 20 | 84827 | 118429 | 63285746 |
Helicobacter infection | 96.96 | 10.78 | 7 | 84840 | 92778 | 63311397 |
Abnormal behaviour | 95.38 | 10.78 | 130 | 84717 | 21296 | 63382879 |
Lymphocyte stimulation test positive | 95.16 | 10.78 | 33 | 84814 | 486 | 63403689 |
Aura | 91.26 | 10.78 | 39 | 84808 | 1034 | 63403141 |
Death | 87.40 | 10.78 | 236 | 84611 | 374145 | 63030030 |
Intentional product use issue | 87.11 | 10.78 | 31 | 84816 | 127861 | 63276314 |
Impaired healing | 86.76 | 10.78 | 16 | 84831 | 102526 | 63301649 |
Product complaint | 84.96 | 10.78 | 95 | 84752 | 12714 | 63391461 |
Anticonvulsant drug level below therapeutic | 84.82 | 10.78 | 32 | 84815 | 607 | 63403568 |
Constipation | 83.84 | 10.78 | 551 | 84296 | 224392 | 63179783 |
Psoriatic arthropathy | 82.52 | 10.78 | 12 | 84835 | 91508 | 63312667 |
Hyperammonaemic encephalopathy | 81.78 | 10.78 | 47 | 84800 | 2387 | 63401788 |
Speech disorder | 80.70 | 10.78 | 172 | 84675 | 40457 | 63363718 |
Product substitution issue | 80.37 | 10.78 | 103 | 84744 | 15893 | 63388282 |
Nasopharyngitis | 78.59 | 10.78 | 137 | 84710 | 254120 | 63150055 |
Hepatic function abnormal | 76.98 | 10.78 | 160 | 84687 | 36982 | 63367193 |
Musculoskeletal stiffness | 76.79 | 10.78 | 80 | 84767 | 184538 | 63219637 |
Hepatotoxicity | 76.11 | 10.78 | 159 | 84688 | 36882 | 63367293 |
Human herpes virus 6 serology positive | 74.40 | 10.78 | 19 | 84828 | 86 | 63404089 |
Muscle injury | 74.26 | 10.78 | 3 | 84844 | 65342 | 63338833 |
Hypotonia | 74.17 | 10.78 | 76 | 84771 | 9209 | 63394966 |
Pain in extremity | 72.88 | 10.78 | 215 | 84632 | 331271 | 63072904 |
Intellectual disability | 71.55 | 10.78 | 33 | 84814 | 1053 | 63403122 |
Eosinophilia | 71.10 | 10.78 | 117 | 84730 | 22639 | 63381536 |
Back pain | 70.66 | 10.78 | 155 | 84692 | 263990 | 63140185 |
Cerebellar syndrome | 70.30 | 10.78 | 49 | 84798 | 3490 | 63400685 |
Hyperammonaemia | 69.61 | 10.78 | 57 | 84790 | 5175 | 63399000 |
Irritable bowel syndrome | 69.41 | 10.78 | 13 | 84834 | 82399 | 63321776 |
Bradyphrenia | 68.60 | 10.78 | 64 | 84783 | 6916 | 63397259 |
Lymphocyte morphology abnormal | 68.47 | 10.78 | 25 | 84822 | 431 | 63403744 |
Dermatitis exfoliative | 67.49 | 10.78 | 57 | 84790 | 5402 | 63398773 |
Anticonvulsant drug level decreased | 67.08 | 10.78 | 33 | 84814 | 1219 | 63402956 |
Myoclonus | 65.72 | 10.78 | 93 | 84754 | 15775 | 63388400 |
Sudden unexplained death in epilepsy | 64.92 | 10.78 | 22 | 84825 | 301 | 63403874 |
Anaemia | 64.71 | 10.78 | 190 | 84657 | 293240 | 63110935 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 64.49 | 10.78 | 38 | 84809 | 2023 | 63402152 |
Blood bilirubin increased | 63.39 | 10.78 | 148 | 84699 | 36992 | 63367183 |
Cholelithiasis | 63.26 | 10.78 | 164 | 84683 | 43761 | 63360414 |
Dysmorphism | 63.23 | 10.78 | 39 | 84808 | 2257 | 63401918 |
Psychogenic seizure | 63.15 | 10.78 | 35 | 84812 | 1657 | 63402518 |
Oral mucosa erosion | 62.84 | 10.78 | 31 | 84816 | 1152 | 63403023 |
Total lung capacity increased | 60.49 | 10.78 | 38 | 84809 | 2272 | 63401903 |
Acute kidney injury | 59.95 | 10.78 | 168 | 84679 | 263247 | 63140928 |
Arthritis | 59.49 | 10.78 | 41 | 84806 | 115880 | 63288295 |
Multiple sclerosis relapse | 58.85 | 10.78 | 170 | 84677 | 48308 | 63355867 |
Lip erosion | 58.71 | 10.78 | 28 | 84819 | 965 | 63403210 |
General physical health deterioration | 58.23 | 10.78 | 113 | 84734 | 201289 | 63202886 |
Neuroleptic malignant syndrome | 58.02 | 10.78 | 76 | 84771 | 11980 | 63392195 |
Cross sensitivity reaction | 57.71 | 10.78 | 36 | 84811 | 2126 | 63402049 |
Gastrointestinal disorder | 56.69 | 10.78 | 55 | 84792 | 131184 | 63272991 |
Temporal lobe epilepsy | 56.07 | 10.78 | 21 | 84826 | 390 | 63403785 |
Gastric lavage | 55.59 | 10.78 | 13 | 84834 | 37 | 63404138 |
Tonic convulsion | 54.44 | 10.78 | 29 | 84818 | 1268 | 63402907 |
Product dose omission issue | 53.64 | 10.78 | 149 | 84698 | 234164 | 63170011 |
Injection site pain | 53.11 | 10.78 | 57 | 84790 | 129743 | 63274432 |
Fibromyalgia | 52.23 | 10.78 | 21 | 84826 | 80399 | 63323776 |
Vertigo | 51.80 | 10.78 | 187 | 84660 | 59700 | 63344475 |
Oculomucocutaneous syndrome | 51.71 | 10.78 | 15 | 84832 | 118 | 63404057 |
Hip arthroplasty | 51.53 | 10.78 | 3 | 84844 | 47643 | 63356532 |
Neuropathy peripheral | 51.02 | 10.78 | 46 | 84801 | 113621 | 63290554 |
Agitation | 49.50 | 10.78 | 184 | 84663 | 59573 | 63344602 |
Behaviour disorder | 49.30 | 10.78 | 38 | 84809 | 3161 | 63401014 |
Stomatitis | 49.27 | 10.78 | 68 | 84779 | 138657 | 63265518 |
Off label use | 49.08 | 10.78 | 622 | 84225 | 673840 | 62730335 |
Osteoarthritis | 48.55 | 10.78 | 34 | 84813 | 95309 | 63308866 |
Histiocytosis | 48.32 | 10.78 | 10 | 84837 | 12 | 63404163 |
Cough | 48.30 | 10.78 | 214 | 84633 | 292529 | 63111646 |
Foetal anticonvulsant syndrome | 48.21 | 10.78 | 21 | 84826 | 584 | 63403591 |
Intentional self-injury | 47.87 | 10.78 | 106 | 84741 | 25581 | 63378594 |
Mucosal erosion | 47.56 | 10.78 | 28 | 84819 | 1488 | 63402687 |
Irritability | 47.36 | 10.78 | 120 | 84727 | 31574 | 63372601 |
Abdominal pain | 46.93 | 10.78 | 217 | 84630 | 293239 | 63110936 |
Lower respiratory tract infection | 46.84 | 10.78 | 65 | 84782 | 132242 | 63271933 |
Chest pain | 46.74 | 10.78 | 141 | 84706 | 215818 | 63188357 |
Abdominal pain upper | 46.70 | 10.78 | 132 | 84715 | 206312 | 63197863 |
Face oedema | 46.56 | 10.78 | 91 | 84756 | 20121 | 63384054 |
Pyrexia | 46.34 | 10.78 | 884 | 83963 | 469594 | 62934581 |
Nikolsky's sign | 46.02 | 10.78 | 13 | 84834 | 92 | 63404083 |
Extrapyramidal disorder | 45.19 | 10.78 | 71 | 84776 | 13213 | 63390962 |
Tremor | 45.07 | 10.78 | 317 | 84530 | 131922 | 63272253 |
Suicidal ideation | 45.03 | 10.78 | 184 | 84663 | 62237 | 63341938 |
Nausea | 44.84 | 10.78 | 839 | 84008 | 853632 | 62550543 |
Meningomyelocele | 44.57 | 10.78 | 20 | 84827 | 598 | 63403577 |
Pregnancy | 44.54 | 10.78 | 129 | 84718 | 36707 | 63367468 |
Restlessness | 44.51 | 10.78 | 112 | 84735 | 29341 | 63374834 |
Ovarian granulosa-theca cell tumour | 43.99 | 10.78 | 10 | 84837 | 24 | 63404151 |
Malignant neoplasm progression | 43.54 | 10.78 | 28 | 84819 | 82093 | 63322082 |
Ill-defined disorder | 43.18 | 10.78 | 28 | 84819 | 81727 | 63322448 |
Human herpesvirus 6 infection | 43.13 | 10.78 | 34 | 84813 | 2923 | 63401252 |
Asthma | 42.87 | 10.78 | 65 | 84782 | 127496 | 63276679 |
Simple partial seizures | 42.78 | 10.78 | 19 | 84828 | 554 | 63403621 |
Developmental glaucoma | 42.68 | 10.78 | 11 | 84836 | 52 | 63404123 |
Aphasia | 42.27 | 10.78 | 118 | 84729 | 32882 | 63371293 |
Lymphadenopathy | 42.07 | 10.78 | 130 | 84717 | 38328 | 63365847 |
Headache | 42.04 | 10.78 | 595 | 84252 | 632646 | 62771529 |
Mania | 41.93 | 10.78 | 66 | 84781 | 12301 | 63391874 |
Coordination abnormal | 41.93 | 10.78 | 70 | 84777 | 13703 | 63390472 |
Partial seizures with secondary generalisation | 41.82 | 10.78 | 17 | 84830 | 396 | 63403779 |
COVID-19 | 41.63 | 10.78 | 54 | 84793 | 113049 | 63291126 |
Poisoning | 40.87 | 10.78 | 69 | 84778 | 13631 | 63390544 |
Normal newborn | 40.79 | 10.78 | 53 | 84794 | 8288 | 63395887 |
Psychomotor skills impaired | 40.64 | 10.78 | 30 | 84817 | 2338 | 63401837 |
Maternal drugs affecting foetus | 40.23 | 10.78 | 42 | 84805 | 5200 | 63398975 |
Adverse event | 40.17 | 10.78 | 20 | 84827 | 67539 | 63336636 |
Angiofibroma | 39.85 | 10.78 | 12 | 84835 | 109 | 63404066 |
Pain | 39.50 | 10.78 | 725 | 84122 | 739903 | 62664272 |
Obsessive-compulsive disorder | 39.46 | 10.78 | 37 | 84810 | 4023 | 63400152 |
Blood lactate dehydrogenase increased | 39.31 | 10.78 | 92 | 84755 | 23024 | 63381151 |
Sarcoidosis | 39.19 | 10.78 | 48 | 84799 | 7074 | 63397101 |
Hallucination, auditory | 38.80 | 10.78 | 65 | 84782 | 12759 | 63391416 |
Spina bifida | 38.31 | 10.78 | 20 | 84827 | 839 | 63403336 |
Hippocampal sclerosis | 38.21 | 10.78 | 11 | 84836 | 84 | 63404091 |
Change in seizure presentation | 38.06 | 10.78 | 16 | 84831 | 407 | 63403768 |
Central nervous system lesion | 37.79 | 10.78 | 58 | 84789 | 10577 | 63393598 |
Atonic seizures | 37.72 | 10.78 | 18 | 84829 | 621 | 63403554 |
Contusion | 37.70 | 10.78 | 91 | 84756 | 149953 | 63254222 |
Cardiac failure congestive | 37.35 | 10.78 | 41 | 84806 | 92392 | 63311783 |
Adverse drug reaction | 37.30 | 10.78 | 31 | 84816 | 79683 | 63324492 |
Toxic skin eruption | 37.25 | 10.78 | 64 | 84783 | 12821 | 63391354 |
Terminal insomnia | 36.99 | 10.78 | 19 | 84828 | 770 | 63403405 |
Angiomyolipoma | 36.44 | 10.78 | 13 | 84834 | 209 | 63403966 |
Bronchitis | 36.17 | 10.78 | 70 | 84777 | 124865 | 63279310 |
Urinary incontinence | 35.75 | 10.78 | 109 | 84738 | 31905 | 63372270 |
Injection site erythema | 35.74 | 10.78 | 35 | 84812 | 83139 | 63321036 |
Mental disorder | 35.51 | 10.78 | 95 | 84752 | 25824 | 63378351 |
Hepatocellular injury | 35.16 | 10.78 | 98 | 84749 | 27283 | 63376892 |
Hyporeflexia | 34.78 | 10.78 | 25 | 84822 | 1870 | 63402305 |
Mental impairment | 34.17 | 10.78 | 65 | 84782 | 14086 | 63390089 |
Stereotypy | 34.11 | 10.78 | 15 | 84832 | 427 | 63403748 |
Conversion disorder | 34.05 | 10.78 | 24 | 84823 | 1740 | 63402435 |
Febrile convulsion | 34.05 | 10.78 | 15 | 84832 | 429 | 63403746 |
Coma scale abnormal | 33.80 | 10.78 | 38 | 84809 | 5115 | 63399060 |
Oscillopsia | 33.77 | 10.78 | 11 | 84836 | 132 | 63404043 |
Psychomotor hyperactivity | 33.54 | 10.78 | 55 | 84792 | 10608 | 63393567 |
Nephrogenic diabetes insipidus | 33.51 | 10.78 | 19 | 84828 | 940 | 63403235 |
Blood cholesterol increased | 33.47 | 10.78 | 46 | 84801 | 93986 | 63310189 |
Amyloid arthropathy | 33.21 | 10.78 | 16 | 84831 | 564 | 63403611 |
Pregnancy with implant contraceptive | 33.14 | 10.78 | 28 | 84819 | 2655 | 63401520 |
Bursitis | 33.05 | 10.78 | 5 | 84842 | 37036 | 63367139 |
Blood alkaline phosphatase increased | 32.86 | 10.78 | 129 | 84718 | 42838 | 63361337 |
Neurotoxicity | 32.66 | 10.78 | 71 | 84776 | 16919 | 63387256 |
Blood creatine phosphokinase increased | 32.48 | 10.78 | 102 | 84745 | 30328 | 63373847 |
Injection site pruritus | 32.34 | 10.78 | 10 | 84837 | 45106 | 63359069 |
Blood sodium decreased | 32.33 | 10.78 | 88 | 84759 | 24164 | 63380011 |
Loss of personal independence in daily activities | 32.27 | 10.78 | 50 | 84797 | 97240 | 63306935 |
Hypertension | 32.02 | 10.78 | 230 | 84617 | 279073 | 63125102 |
Disturbance in attention | 31.97 | 10.78 | 118 | 84729 | 38071 | 63366104 |
Injection site swelling | 31.58 | 10.78 | 12 | 84835 | 47560 | 63356615 |
Multiple drug therapy | 31.24 | 10.78 | 31 | 84816 | 3615 | 63400560 |
Self esteem decreased | 30.96 | 10.78 | 16 | 84831 | 657 | 63403518 |
Cerebral atrophy | 30.93 | 10.78 | 36 | 84811 | 5030 | 63399145 |
Convulsive threshold lowered | 30.62 | 10.78 | 13 | 84834 | 339 | 63403836 |
Dizziness | 30.53 | 10.78 | 771 | 84076 | 429154 | 62975021 |
Nasal polyps | 30.51 | 10.78 | 39 | 84808 | 6000 | 63398175 |
Pneumonia | 30.31 | 10.78 | 429 | 84418 | 456338 | 62947837 |
Shock | 30.15 | 10.78 | 84 | 84763 | 23379 | 63380796 |
Teratogenicity | 30.12 | 10.78 | 12 | 84835 | 265 | 63403910 |
Multiple sclerosis | 30.09 | 10.78 | 86 | 84761 | 24286 | 63379889 |
Bradycardia | 30.08 | 10.78 | 184 | 84663 | 73043 | 63331132 |
Unintended pregnancy | 29.81 | 10.78 | 39 | 84808 | 6140 | 63398035 |
Weight decreased | 29.79 | 10.78 | 232 | 84615 | 276566 | 63127609 |
Hypogammaglobulinaemia | 29.72 | 10.78 | 42 | 84805 | 7113 | 63397062 |
Disease progression | 29.62 | 10.78 | 76 | 84771 | 122682 | 63281493 |
Diabetes insipidus | 29.59 | 10.78 | 26 | 84821 | 2599 | 63401576 |
Bacteriuria | 29.29 | 10.78 | 18 | 84829 | 1035 | 63403140 |
Musculoskeletal pain | 29.13 | 10.78 | 49 | 84798 | 92228 | 63311947 |
Dyspepsia | 28.94 | 10.78 | 58 | 84789 | 102138 | 63302037 |
Hospitalisation | 28.92 | 10.78 | 43 | 84804 | 85038 | 63319137 |
Myocardial infarction | 28.88 | 10.78 | 56 | 84791 | 99837 | 63304338 |
Delusion | 28.78 | 10.78 | 55 | 84792 | 11962 | 63392213 |
Ophthalmoplegia | 28.45 | 10.78 | 20 | 84827 | 1444 | 63402731 |
Eye movement disorder | 28.39 | 10.78 | 35 | 84812 | 5193 | 63398982 |
Thinking abnormal | 28.36 | 10.78 | 51 | 84796 | 10592 | 63393583 |
Atrial fibrillation | 28.30 | 10.78 | 72 | 84775 | 116564 | 63287611 |
Gingival hypertrophy | 28.30 | 10.78 | 21 | 84826 | 1650 | 63402525 |
Polydipsia | 28.15 | 10.78 | 29 | 84818 | 3535 | 63400640 |
Caesarean section | 28.11 | 10.78 | 67 | 84780 | 16965 | 63387210 |
Diverticulitis | 27.94 | 10.78 | 9 | 84838 | 39548 | 63364627 |
Foetal exposure during pregnancy | 27.80 | 10.78 | 100 | 84747 | 31862 | 63372313 |
Conjunctival hyperaemia | 27.70 | 10.78 | 24 | 84823 | 2355 | 63401820 |
Gastrointestinal haemorrhage | 27.62 | 10.78 | 41 | 84806 | 81135 | 63323040 |
Facial pain | 27.37 | 10.78 | 50 | 84797 | 10511 | 63393664 |
Hypervolaemia | 27.36 | 10.78 | 3 | 84844 | 28410 | 63375765 |
Fulminant type 1 diabetes mellitus | 26.89 | 10.78 | 13 | 84834 | 462 | 63403713 |
Lymphangioleiomyomatosis | 26.89 | 10.78 | 10 | 84837 | 182 | 63403993 |
Epileptic psychosis | 26.84 | 10.78 | 7 | 84840 | 35 | 63404140 |
Psychiatric symptom | 26.82 | 10.78 | 34 | 84813 | 5189 | 63398986 |
Psoriasis | 26.69 | 10.78 | 47 | 84800 | 86910 | 63317265 |
Gaze palsy | 26.67 | 10.78 | 19 | 84828 | 1401 | 63402774 |
Drug withdrawal convulsions | 26.61 | 10.78 | 19 | 84828 | 1406 | 63402769 |
Mood altered | 26.53 | 10.78 | 60 | 84787 | 14683 | 63389492 |
Colitis | 26.48 | 10.78 | 16 | 84831 | 48512 | 63355663 |
Device expulsion | 26.40 | 10.78 | 7 | 84840 | 34915 | 63369260 |
Persecutory delusion | 26.30 | 10.78 | 25 | 84822 | 2765 | 63401410 |
Paradoxical drug reaction | 26.18 | 10.78 | 30 | 84817 | 4122 | 63400053 |
Urinary tract infection | 26.13 | 10.78 | 227 | 84620 | 264457 | 63139718 |
Injection site reaction | 25.88 | 10.78 | 24 | 84823 | 58500 | 63345675 |
Areflexia | 25.77 | 10.78 | 26 | 84821 | 3092 | 63401083 |
SUNCT syndrome | 25.75 | 10.78 | 5 | 84842 | 3 | 63404172 |
Joint stiffness | 25.49 | 10.78 | 12 | 84835 | 41857 | 63362318 |
Joint range of motion decreased | 25.48 | 10.78 | 6 | 84841 | 32422 | 63371753 |
Stupor | 25.47 | 10.78 | 30 | 84817 | 4245 | 63399930 |
Bipolar disorder | 24.96 | 10.78 | 41 | 84806 | 7919 | 63396256 |
Right ventricular dilatation | 24.90 | 10.78 | 18 | 84829 | 1358 | 63402817 |
Osteonecrosis of jaw | 24.79 | 10.78 | 8 | 84839 | 35115 | 63369060 |
Fluid retention | 24.64 | 10.78 | 26 | 84821 | 59660 | 63344515 |
Neuromyelitis optica spectrum disorder | 24.57 | 10.78 | 16 | 84831 | 1018 | 63403157 |
Disorientation | 24.38 | 10.78 | 111 | 84736 | 39341 | 63364834 |
Intra-abdominal pressure increased | 24.36 | 10.78 | 10 | 84837 | 239 | 63403936 |
Catatonia | 24.35 | 10.78 | 30 | 84817 | 4447 | 63399728 |
Influenza | 24.21 | 10.78 | 70 | 84777 | 108652 | 63295523 |
Memory impairment | 24.16 | 10.78 | 229 | 84618 | 104029 | 63300146 |
Blood hyposmosis | 24.09 | 10.78 | 6 | 84841 | 24 | 63404151 |
Genital erosion | 24.09 | 10.78 | 9 | 84838 | 166 | 63404009 |
Illusion | 24.07 | 10.78 | 16 | 84831 | 1054 | 63403121 |
Cardiac arrest | 23.85 | 10.78 | 208 | 84639 | 92337 | 63311838 |
Dyskinesia | 23.60 | 10.78 | 95 | 84752 | 31907 | 63372268 |
Pseudolymphoma | 23.44 | 10.78 | 13 | 84834 | 616 | 63403559 |
Ammonia increased | 23.42 | 10.78 | 30 | 84817 | 4626 | 63399549 |
Pulmonary pain | 23.34 | 10.78 | 26 | 84821 | 3464 | 63400711 |
Gait disturbance | 23.33 | 10.78 | 359 | 84488 | 182819 | 63221356 |
Petechiae | 23.29 | 10.78 | 55 | 84792 | 13842 | 63390333 |
Polydipsia psychogenic | 23.20 | 10.78 | 7 | 84840 | 64 | 63404111 |
Epileptic aura | 23.01 | 10.78 | 7 | 84840 | 66 | 63404109 |
Mitochondrial enzyme deficiency | 23.00 | 10.78 | 6 | 84841 | 30 | 63404145 |
Erythema | 22.98 | 10.78 | 346 | 84501 | 175405 | 63228770 |
Chest discomfort | 22.92 | 10.78 | 73 | 84774 | 109896 | 63294279 |
Vaccination site reaction | 22.87 | 10.78 | 8 | 84839 | 121 | 63404054 |
Epidermolysis bullosa | 22.81 | 10.78 | 8 | 84839 | 122 | 63404053 |
Respiratory arrest | 22.57 | 10.78 | 95 | 84752 | 32550 | 63371625 |
Learning disorder | 22.41 | 10.78 | 13 | 84834 | 672 | 63403503 |
Sciatica | 22.22 | 10.78 | 9 | 84838 | 34315 | 63369860 |
Ear malformation | 22.01 | 10.78 | 9 | 84838 | 213 | 63403962 |
Skin erosion | 21.99 | 10.78 | 22 | 84825 | 2590 | 63401585 |
Mydriasis | 21.89 | 10.78 | 49 | 84798 | 11907 | 63392268 |
Deafness congenital | 21.71 | 10.78 | 5 | 84842 | 13 | 63404162 |
Disorganised speech | 21.65 | 10.78 | 16 | 84831 | 1249 | 63402926 |
Anaemia megaloblastic | 21.57 | 10.78 | 11 | 84836 | 439 | 63403736 |
Pleural effusion | 21.50 | 10.78 | 59 | 84788 | 93151 | 63311024 |
Eosinophil count increased | 21.39 | 10.78 | 46 | 84801 | 10882 | 63393293 |
Immune thrombocytopenia | 21.31 | 10.78 | 45 | 84802 | 10511 | 63393664 |
Encapsulating peritoneal sclerosis | 21.09 | 10.78 | 10 | 84837 | 340 | 63403835 |
Slow speech | 21.06 | 10.78 | 17 | 84830 | 1512 | 63402663 |
Ultrasound ovary abnormal | 21.05 | 10.78 | 7 | 84840 | 90 | 63404085 |
Seizure cluster | 21.05 | 10.78 | 9 | 84838 | 239 | 63403936 |
Hepatitis | 21.01 | 10.78 | 107 | 84740 | 39681 | 63364494 |
Antipsychotic drug level decreased | 21.01 | 10.78 | 10 | 84837 | 343 | 63403832 |
Abortion | 20.97 | 10.78 | 21 | 84826 | 2475 | 63401700 |
Hyperthermia | 20.82 | 10.78 | 41 | 84806 | 9115 | 63395060 |
Clostridium difficile infection | 20.80 | 10.78 | 7 | 84840 | 29915 | 63374260 |
Euphoric mood | 20.77 | 10.78 | 29 | 84818 | 4858 | 63399317 |
Apathy | 20.75 | 10.78 | 40 | 84807 | 8754 | 63395421 |
Dysphagia | 20.74 | 10.78 | 195 | 84652 | 88390 | 63315785 |
Palpitations | 20.71 | 10.78 | 79 | 84768 | 112691 | 63291484 |
Single umbilical artery | 20.57 | 10.78 | 9 | 84838 | 253 | 63403922 |
Respiratory depression | 20.56 | 10.78 | 52 | 84795 | 13663 | 63390512 |
Oxygen saturation decreased | 20.49 | 10.78 | 56 | 84791 | 88529 | 63315646 |
Productive cough | 20.47 | 10.78 | 33 | 84814 | 63175 | 63341000 |
Dexamethasone suppression test positive | 20.24 | 10.78 | 4 | 84843 | 3 | 63404172 |
Macular degeneration | 20.19 | 10.78 | 4 | 84843 | 24372 | 63379803 |
Sepsis | 20.10 | 10.78 | 121 | 84726 | 153002 | 63251173 |
Amnesia | 19.95 | 10.78 | 135 | 84712 | 55450 | 63348725 |
Knee arthroplasty | 19.81 | 10.78 | 26 | 84821 | 54180 | 63349995 |
Alanine aminotransferase increased | 19.78 | 10.78 | 219 | 84628 | 103551 | 63300624 |
Benzodiazepine drug level increased | 19.78 | 10.78 | 8 | 84839 | 184 | 63403991 |
Affective disorder | 19.74 | 10.78 | 32 | 84815 | 6114 | 63398061 |
Congenital spinal fusion | 19.71 | 10.78 | 4 | 84843 | 4 | 63404171 |
Pyuria | 19.68 | 10.78 | 18 | 84829 | 1896 | 63402279 |
Chronic kidney disease | 19.62 | 10.78 | 19 | 84828 | 45379 | 63358796 |
Cardiac murmur | 19.59 | 10.78 | 53 | 84794 | 14499 | 63389676 |
Hypomagnesaemia | 19.49 | 10.78 | 7 | 84840 | 28730 | 63375445 |
Lethargy | 19.49 | 10.78 | 135 | 84712 | 55872 | 63348303 |
Toxic encephalopathy | 19.44 | 10.78 | 33 | 84814 | 6546 | 63397629 |
Cranial nerve disorder | 19.41 | 10.78 | 11 | 84836 | 544 | 63403631 |
Sinus arrest | 19.40 | 10.78 | 18 | 84829 | 1931 | 63402244 |
Developmental delay | 19.40 | 10.78 | 16 | 84831 | 1467 | 63402708 |
Cleft lip | 19.37 | 10.78 | 7 | 84840 | 117 | 63404058 |
Dystonia | 19.28 | 10.78 | 51 | 84796 | 13768 | 63390407 |
Liver injury | 19.22 | 10.78 | 32 | 84815 | 60488 | 63343687 |
Bone pain | 19.17 | 10.78 | 27 | 84820 | 54614 | 63349561 |
Lymphocytosis | 19.17 | 10.78 | 21 | 84826 | 2746 | 63401429 |
Abortion threatened | 19.10 | 10.78 | 11 | 84836 | 561 | 63403614 |
Dyspnoea exertional | 19.05 | 10.78 | 32 | 84815 | 60270 | 63343905 |
Inflammation | 19.03 | 10.78 | 52 | 84795 | 82221 | 63321954 |
Pneumatosis | 19.03 | 10.78 | 10 | 84837 | 425 | 63403750 |
Developmental regression | 18.85 | 10.78 | 5 | 84842 | 27 | 63404148 |
Cellulitis | 18.81 | 10.78 | 52 | 84795 | 81906 | 63322269 |
Blood osmolarity decreased | 18.79 | 10.78 | 13 | 84834 | 915 | 63403260 |
Peripheral nerve decompression | 18.70 | 10.78 | 5 | 84842 | 28 | 63404147 |
Microcephaly | 18.64 | 10.78 | 13 | 84834 | 927 | 63403248 |
Hypoproteinaemia | 18.63 | 10.78 | 18 | 84829 | 2031 | 63402144 |
Skin ulcer | 18.62 | 10.78 | 18 | 84829 | 43027 | 63361148 |
Encephalocele | 18.45 | 10.78 | 7 | 84840 | 135 | 63404040 |
Therapeutic response unexpected | 18.32 | 10.78 | 61 | 84786 | 18698 | 63385477 |
Labelled drug-drug interaction medication error | 18.24 | 10.78 | 49 | 84798 | 13350 | 63390825 |
Blood pressure fluctuation | 18.21 | 10.78 | 21 | 84826 | 46296 | 63357879 |
Dry mouth | 18.17 | 10.78 | 49 | 84798 | 77814 | 63326361 |
Upper respiratory tract infection | 18.14 | 10.78 | 53 | 84794 | 81994 | 63322181 |
Conjunctivitis | 18.03 | 10.78 | 65 | 84782 | 20731 | 63383444 |
Psychomotor retardation | 18.01 | 10.78 | 24 | 84823 | 3846 | 63400329 |
Sensorimotor disorder | 17.99 | 10.78 | 10 | 84837 | 476 | 63403699 |
Acinetobacter test positive | 17.99 | 10.78 | 6 | 84841 | 78 | 63404097 |
Full blood count abnormal | 17.95 | 10.78 | 10 | 84837 | 31707 | 63372468 |
Purpura | 17.94 | 10.78 | 44 | 84803 | 11341 | 63392834 |
Medulloblastoma | 17.87 | 10.78 | 5 | 84842 | 34 | 63404141 |
Septic shock | 17.86 | 10.78 | 39 | 84808 | 66590 | 63337585 |
Mucosal inflammation | 17.68 | 10.78 | 22 | 84825 | 46906 | 63357269 |
Pleural neoplasm | 17.59 | 10.78 | 9 | 84838 | 362 | 63403813 |
Haemoglobin decreased | 17.54 | 10.78 | 118 | 84729 | 145367 | 63258808 |
Product dispensing error | 17.51 | 10.78 | 41 | 84806 | 10264 | 63393911 |
Dementia | 17.37 | 10.78 | 60 | 84787 | 18734 | 63385441 |
Confusional state | 17.35 | 10.78 | 426 | 84421 | 235954 | 63168221 |
Pneumonitis | 17.35 | 10.78 | 13 | 84834 | 35209 | 63368966 |
Carbohydrate antigen 15-3 | 17.26 | 10.78 | 6 | 84841 | 89 | 63404086 |
Neoplasm progression | 17.24 | 10.78 | 14 | 84833 | 36414 | 63367761 |
Neurosis | 17.21 | 10.78 | 8 | 84839 | 260 | 63403915 |
Lactate pyruvate ratio increased | 17.20 | 10.78 | 6 | 84841 | 90 | 63404085 |
Muscle spasms | 17.19 | 10.78 | 130 | 84717 | 156020 | 63248155 |
Acid base balance abnormal | 17.18 | 10.78 | 8 | 84839 | 261 | 63403914 |
Autism spectrum disorder | 17.17 | 10.78 | 12 | 84835 | 858 | 63403317 |
Atrioventricular block | 17.09 | 10.78 | 34 | 84813 | 7613 | 63396562 |
Carcinoembryonic antigen | 17.08 | 10.78 | 6 | 84841 | 92 | 63404083 |
Interstitial granulomatous dermatitis | 17.05 | 10.78 | 5 | 84842 | 41 | 63404134 |
Eyelid oedema | 17.05 | 10.78 | 41 | 84806 | 10438 | 63393737 |
Accidental overdose | 17.03 | 10.78 | 69 | 84778 | 23240 | 63380935 |
Rhesus incompatibility | 16.96 | 10.78 | 6 | 84841 | 94 | 63404081 |
Lennox-Gastaut syndrome | 16.96 | 10.78 | 8 | 84839 | 269 | 63403906 |
Urticaria vesiculosa | 16.95 | 10.78 | 4 | 84843 | 12 | 63404163 |
Tensilon test abnormal | 16.86 | 10.78 | 3 | 84844 | 0 | 63404175 |
Brain lobectomy | 16.86 | 10.78 | 3 | 84844 | 0 | 63404175 |
Lymphocyte transformation test positive | 16.86 | 10.78 | 3 | 84844 | 0 | 63404175 |
Therapeutic product effective for unapproved indication | 16.84 | 10.78 | 6 | 84841 | 96 | 63404079 |
Drug level above therapeutic | 16.78 | 10.78 | 26 | 84821 | 4779 | 63399396 |
Pulmonary valve stenosis congenital | 16.76 | 10.78 | 7 | 84840 | 175 | 63404000 |
Wound infection | 16.75 | 10.78 | 4 | 84843 | 21406 | 63382769 |
Pulmonary hypertension | 16.68 | 10.78 | 15 | 84832 | 37108 | 63367067 |
Lymphopenia | 16.50 | 10.78 | 58 | 84789 | 18269 | 63385906 |
Hyperphosphatasaemia | 16.48 | 10.78 | 4 | 84843 | 14 | 63404161 |
Rectal haemorrhage | 16.45 | 10.78 | 25 | 84822 | 49005 | 63355170 |
Epileptic encephalopathy | 16.43 | 10.78 | 8 | 84839 | 289 | 63403886 |
Osteomalacia | 16.42 | 10.78 | 11 | 84836 | 734 | 63403441 |
Enanthema | 16.42 | 10.78 | 9 | 84838 | 417 | 63403758 |
Ideas of reference | 16.40 | 10.78 | 6 | 84841 | 104 | 63404071 |
Injection site haemorrhage | 16.36 | 10.78 | 6 | 84841 | 24308 | 63379867 |
Hyperacusis | 16.34 | 10.78 | 17 | 84830 | 2096 | 63402079 |
Obsessive thoughts | 16.18 | 10.78 | 10 | 84837 | 581 | 63403594 |
Red blood cell sedimentation rate increased | 16.17 | 10.78 | 21 | 84826 | 43961 | 63360214 |
Epistaxis | 16.06 | 10.78 | 47 | 84800 | 72678 | 63331497 |
Asterixis | 16.06 | 10.78 | 14 | 84833 | 1385 | 63402790 |
Wrong drug | 16.03 | 10.78 | 7 | 84840 | 196 | 63403979 |
Joint injury | 15.78 | 10.78 | 10 | 84837 | 29562 | 63374613 |
Syncope | 15.69 | 10.78 | 232 | 84615 | 117153 | 63287022 |
Herpes zoster | 15.64 | 10.78 | 57 | 84790 | 82405 | 63321770 |
Cholestasis | 15.43 | 10.78 | 79 | 84768 | 29355 | 63374820 |
Blood citric acid increased | 15.43 | 10.78 | 5 | 84842 | 59 | 63404116 |
Injection site bruising | 15.42 | 10.78 | 20 | 84827 | 41890 | 63362285 |
Cardiac failure | 15.38 | 10.78 | 64 | 84783 | 89078 | 63315097 |
Brain injury | 15.37 | 10.78 | 31 | 84816 | 7012 | 63397163 |
Derailment | 15.35 | 10.78 | 5 | 84842 | 60 | 63404115 |
Tearfulness | 15.31 | 10.78 | 23 | 84824 | 4116 | 63400059 |
Pupillary disorder | 15.30 | 10.78 | 7 | 84840 | 219 | 63403956 |
Therapeutic product ineffective for unapproved indication | 15.30 | 10.78 | 7 | 84840 | 219 | 63403956 |
Depressed mood | 15.26 | 10.78 | 99 | 84748 | 40092 | 63364083 |
Myalgia | 15.19 | 10.78 | 124 | 84723 | 146405 | 63257770 |
Hepatitis A | 15.19 | 10.78 | 9 | 84838 | 484 | 63403691 |
Paranoia | 15.19 | 10.78 | 42 | 84805 | 11637 | 63392538 |
Aspartate aminotransferase increased | 15.19 | 10.78 | 186 | 84661 | 90091 | 63314084 |
Persistent depressive disorder | 15.16 | 10.78 | 12 | 84835 | 1038 | 63403137 |
Hyperkalaemia | 15.14 | 10.78 | 31 | 84816 | 54172 | 63350003 |
Rhinitis allergic | 15.08 | 10.78 | 42 | 84805 | 11685 | 63392490 |
Hallucination | 15.07 | 10.78 | 125 | 84722 | 54692 | 63349483 |
Metapneumovirus infection | 15.06 | 10.78 | 12 | 84835 | 1048 | 63403127 |
Type 2 diabetes mellitus | 15.05 | 10.78 | 40 | 84807 | 63828 | 63340347 |
Necrosis ischaemic | 15.00 | 10.78 | 11 | 84836 | 849 | 63403326 |
Speech disorder developmental | 14.89 | 10.78 | 10 | 84837 | 670 | 63403505 |
Nervous system disorder | 14.88 | 10.78 | 57 | 84790 | 18709 | 63385466 |
Fabry's disease | 14.78 | 10.78 | 3 | 84844 | 3 | 63404172 |
Urinary tract malformation | 14.78 | 10.78 | 3 | 84844 | 3 | 63404172 |
Epilepsy surgery | 14.73 | 10.78 | 4 | 84843 | 24 | 63404151 |
Juvenile myoclonic epilepsy | 14.73 | 10.78 | 4 | 84843 | 24 | 63404151 |
Lung disorder | 14.67 | 10.78 | 39 | 84808 | 62222 | 63341953 |
Haematochezia | 14.64 | 10.78 | 31 | 84816 | 53513 | 63350662 |
Oral mucosal eruption | 14.56 | 10.78 | 10 | 84837 | 695 | 63403480 |
Rash morbilliform | 14.53 | 10.78 | 20 | 84827 | 3305 | 63400870 |
Periodic limb movement disorder | 14.52 | 10.78 | 7 | 84840 | 247 | 63403928 |
Pulmonary mass | 14.51 | 10.78 | 6 | 84841 | 22590 | 63381585 |
Decreased appetite | 14.50 | 10.78 | 242 | 84605 | 250810 | 63153365 |
Night sweats | 14.43 | 10.78 | 27 | 84820 | 48787 | 63355388 |
Brugada syndrome | 14.41 | 10.78 | 8 | 84839 | 380 | 63403795 |
Anaphylactic reaction | 14.39 | 10.78 | 43 | 84804 | 66057 | 63338118 |
Congenital megaureter | 14.33 | 10.78 | 5 | 84842 | 75 | 63404100 |
Injury | 14.31 | 10.78 | 50 | 84797 | 73197 | 63330978 |
Vitamin D deficiency | 14.31 | 10.78 | 46 | 84801 | 13846 | 63390329 |
Developmental hip dysplasia | 14.30 | 10.78 | 13 | 84834 | 1359 | 63402816 |
Skin test positive | 14.22 | 10.78 | 10 | 84837 | 722 | 63403453 |
Vanishing bile duct syndrome | 14.22 | 10.78 | 10 | 84837 | 722 | 63403453 |
Basal cell carcinoma | 14.22 | 10.78 | 10 | 84837 | 27981 | 63376194 |
Pseudophaeochromocytoma | 14.21 | 10.78 | 5 | 84842 | 77 | 63404098 |
Vaginal erosion | 14.20 | 10.78 | 4 | 84843 | 28 | 63404147 |
Thrombosis | 14.19 | 10.78 | 42 | 84805 | 64713 | 63339462 |
Odynophagia | 14.07 | 10.78 | 31 | 84816 | 7455 | 63396720 |
Trigeminal nerve disorder | 14.04 | 10.78 | 6 | 84841 | 159 | 63404016 |
Cerebellar atrophy | 14.03 | 10.78 | 10 | 84837 | 738 | 63403437 |
Congenital cystic kidney disease | 14.02 | 10.78 | 8 | 84839 | 401 | 63403774 |
Hypothermia | 14.01 | 10.78 | 45 | 84802 | 13536 | 63390639 |
Hypomania | 13.98 | 10.78 | 28 | 84819 | 6302 | 63397873 |
Near drowning | 13.96 | 10.78 | 4 | 84843 | 30 | 63404145 |
Hepatitis fulminant | 13.90 | 10.78 | 20 | 84827 | 3444 | 63400731 |
Thyroid adenoma | 13.84 | 10.78 | 6 | 84841 | 165 | 63404010 |
Hyperlactacidaemia | 13.77 | 10.78 | 18 | 84829 | 2831 | 63401344 |
Infrapatellar fat pad inflammation | 13.77 | 10.78 | 6 | 84841 | 167 | 63404008 |
Hypoglycaemia neonatal | 13.77 | 10.78 | 11 | 84836 | 964 | 63403211 |
Paralogism | 13.73 | 10.78 | 4 | 84843 | 32 | 63404143 |
Hypometabolism | 13.73 | 10.78 | 4 | 84843 | 32 | 63404143 |
Pharyngeal erythema | 13.68 | 10.78 | 14 | 84833 | 1694 | 63402481 |
Blood immunoglobulin M decreased | 13.64 | 10.78 | 11 | 84836 | 977 | 63403198 |
Genital burning sensation | 13.60 | 10.78 | 7 | 84840 | 285 | 63403890 |
Enlarged foetal cisterna magna | 13.57 | 10.78 | 3 | 84844 | 6 | 63404169 |
Papule | 13.57 | 10.78 | 26 | 84821 | 5665 | 63398510 |
Vaginal ulceration | 13.54 | 10.78 | 8 | 84839 | 428 | 63403747 |
Photophobia | 13.53 | 10.78 | 53 | 84794 | 17582 | 63386593 |
Hyperprolactinaemia | 13.48 | 10.78 | 21 | 84826 | 3879 | 63400296 |
Drug-induced liver injury | 13.44 | 10.78 | 96 | 84751 | 40126 | 63364049 |
Blood pressure increased | 13.43 | 10.78 | 145 | 84702 | 161917 | 63242258 |
Tooth development disorder | 13.41 | 10.78 | 4 | 84843 | 35 | 63404140 |
Procedural pain | 13.41 | 10.78 | 6 | 84841 | 21563 | 63382612 |
Quadriparesis | 13.37 | 10.78 | 15 | 84832 | 2014 | 63402161 |
Pigmentation disorder | 13.36 | 10.78 | 23 | 84824 | 4616 | 63399559 |
Skin exfoliation | 13.33 | 10.78 | 101 | 84746 | 43001 | 63361174 |
Anal erosion | 13.31 | 10.78 | 4 | 84843 | 36 | 63404139 |
Candida infection | 13.29 | 10.78 | 11 | 84836 | 28340 | 63375835 |
Acquired diaphragmatic eventration | 13.27 | 10.78 | 8 | 84839 | 444 | 63403731 |
Hypercalcaemia | 13.26 | 10.78 | 11 | 84836 | 28311 | 63375864 |
Hyperglycinaemia | 13.26 | 10.78 | 3 | 84844 | 7 | 63404168 |
Aortic bypass | 13.26 | 10.78 | 3 | 84844 | 7 | 63404168 |
Fungal infection | 13.16 | 10.78 | 18 | 84829 | 36856 | 63367319 |
Skin lesion | 13.12 | 10.78 | 78 | 84769 | 30643 | 63373532 |
Dry skin | 13.12 | 10.78 | 36 | 84811 | 56851 | 63347324 |
Postictal state | 13.12 | 10.78 | 11 | 84836 | 1032 | 63403143 |
Respiratory tract infection | 13.11 | 10.78 | 22 | 84825 | 41461 | 63362714 |
Sinus congestion | 13.02 | 10.78 | 4 | 84843 | 18119 | 63386056 |
Carnitine decreased | 12.97 | 10.78 | 3 | 84844 | 8 | 63404167 |
Pulmonary arterial hypertension | 12.95 | 10.78 | 7 | 84840 | 22570 | 63381605 |
Agranulocytosis | 12.86 | 10.78 | 67 | 84780 | 25067 | 63379108 |
Trance | 12.85 | 10.78 | 4 | 84843 | 41 | 63404134 |
Nodule | 12.84 | 10.78 | 6 | 84841 | 21020 | 63383155 |
Poverty of speech | 12.83 | 10.78 | 7 | 84840 | 321 | 63403854 |
Disseminated intravascular coagulation | 12.83 | 10.78 | 55 | 84792 | 18996 | 63385179 |
Wheezing | 12.82 | 10.78 | 75 | 84772 | 95520 | 63308655 |
Conjunctival discolouration | 12.78 | 10.78 | 5 | 84842 | 105 | 63404070 |
Arnold-Chiari malformation | 12.73 | 10.78 | 9 | 84838 | 656 | 63403519 |
Angiosclerosis | 12.71 | 10.78 | 3 | 84844 | 9 | 63404166 |
Norovirus infection | 12.67 | 10.78 | 9 | 84838 | 661 | 63403514 |
Anticoagulation drug level decreased | 12.52 | 10.78 | 4 | 84843 | 45 | 63404130 |
Cataract | 12.50 | 10.78 | 37 | 84810 | 57016 | 63347159 |
Dehydration | 12.48 | 10.78 | 160 | 84687 | 173194 | 63230981 |
Therapy interrupted | 12.45 | 10.78 | 15 | 84832 | 32440 | 63371735 |
Incoherent | 12.44 | 10.78 | 22 | 84825 | 4508 | 63399667 |
Altered visual depth perception | 12.43 | 10.78 | 7 | 84840 | 342 | 63403833 |
Colitis ulcerative | 12.38 | 10.78 | 10 | 84837 | 26081 | 63378094 |
Cerebellar ataxia | 12.36 | 10.78 | 10 | 84837 | 892 | 63403283 |
Drug dependence | 12.34 | 10.78 | 65 | 84782 | 24418 | 63379757 |
Facial spasm | 12.32 | 10.78 | 9 | 84838 | 690 | 63403485 |
Full blood count decreased | 12.32 | 10.78 | 10 | 84837 | 26014 | 63378161 |
Drug level changed | 12.31 | 10.78 | 6 | 84841 | 217 | 63403958 |
Drug tolerance decreased | 12.30 | 10.78 | 4 | 84843 | 17469 | 63386706 |
Lymphocytic infiltration | 12.29 | 10.78 | 10 | 84837 | 900 | 63403275 |
Selective IgG subclass deficiency | 12.25 | 10.78 | 3 | 84844 | 11 | 63404164 |
Acantholysis | 12.25 | 10.78 | 3 | 84844 | 11 | 63404164 |
Thrombocytopenic purpura | 12.24 | 10.78 | 12 | 84835 | 1379 | 63402796 |
Encephalopathy | 12.23 | 10.78 | 91 | 84756 | 38529 | 63365646 |
Neonatal seizure | 12.21 | 10.78 | 8 | 84839 | 514 | 63403661 |
Kidney duplex | 12.13 | 10.78 | 4 | 84843 | 50 | 63404125 |
Negative thoughts | 12.12 | 10.78 | 10 | 84837 | 917 | 63403258 |
Papillary thyroid cancer | 12.08 | 10.78 | 15 | 84832 | 2241 | 63401934 |
Hepatitis acute | 12.06 | 10.78 | 33 | 84814 | 9087 | 63395088 |
Pulmonary venous thrombosis | 12.05 | 10.78 | 3 | 84844 | 12 | 63404163 |
Frequent bowel movements | 11.99 | 10.78 | 8 | 84839 | 23014 | 63381161 |
Basilar migraine | 11.99 | 10.78 | 4 | 84843 | 52 | 63404123 |
Sinus node dysfunction | 11.91 | 10.78 | 22 | 84825 | 4663 | 63399512 |
Peripheral venous disease | 11.89 | 10.78 | 3 | 84844 | 15474 | 63388701 |
Hemiparesis | 11.87 | 10.78 | 62 | 84785 | 23220 | 63380955 |
Pregnancy on contraceptive | 11.85 | 10.78 | 11 | 84836 | 1181 | 63402994 |
Neuralgia | 11.84 | 10.78 | 67 | 84780 | 25859 | 63378316 |
Mouth ulceration | 11.77 | 10.78 | 80 | 84767 | 32904 | 63371271 |
Congenital foot malformation | 11.75 | 10.78 | 6 | 84841 | 240 | 63403935 |
Anger | 11.72 | 10.78 | 40 | 84807 | 12416 | 63391759 |
Skin oedema | 11.70 | 10.78 | 10 | 84837 | 963 | 63403212 |
Gastric ulcer | 11.68 | 10.78 | 9 | 84838 | 24028 | 63380147 |
Urine calcium decreased | 11.67 | 10.78 | 3 | 84844 | 14 | 63404161 |
SJS-TEN overlap | 11.66 | 10.78 | 7 | 84840 | 386 | 63403789 |
Neonatal hypotension | 11.65 | 10.78 | 5 | 84842 | 134 | 63404041 |
Blood osmolarity increased | 11.64 | 10.78 | 6 | 84841 | 245 | 63403930 |
Premature labour | 11.63 | 10.78 | 40 | 84807 | 12464 | 63391711 |
Transfusion | 11.60 | 10.78 | 3 | 84844 | 15214 | 63388961 |
Lip ulceration | 11.58 | 10.78 | 14 | 84833 | 2036 | 63402139 |
Anal atresia | 11.57 | 10.78 | 7 | 84840 | 391 | 63403784 |
Enlarged cerebral perivascular spaces | 11.50 | 10.78 | 3 | 84844 | 15 | 63404160 |
Tooth malformation | 11.50 | 10.78 | 3 | 84844 | 15 | 63404160 |
Congenital anomaly | 11.48 | 10.78 | 13 | 84834 | 1763 | 63402412 |
Dermatitis bullous | 11.47 | 10.78 | 31 | 84816 | 8477 | 63395698 |
Educational problem | 11.44 | 10.78 | 7 | 84840 | 399 | 63403776 |
Hypotonia neonatal | 11.43 | 10.78 | 11 | 84836 | 1235 | 63402940 |
Haemangioma | 11.38 | 10.78 | 16 | 84831 | 2696 | 63401479 |
Depressive symptom | 11.37 | 10.78 | 20 | 84827 | 4082 | 63400093 |
Gastroenteritis viral | 11.35 | 10.78 | 9 | 84838 | 23691 | 63380484 |
Head injury | 11.35 | 10.78 | 69 | 84778 | 27327 | 63376848 |
Drug level below therapeutic | 11.32 | 10.78 | 22 | 84825 | 4844 | 63399331 |
Gastrooesophageal reflux disease | 11.31 | 10.78 | 78 | 84769 | 95561 | 63308614 |
Grip strength decreased | 11.27 | 10.78 | 8 | 84839 | 22279 | 63381896 |
Throat tightness | 11.25 | 10.78 | 10 | 84837 | 24877 | 63379298 |
Granulocytopenia | 11.24 | 10.78 | 24 | 84823 | 5648 | 63398527 |
Impaired driving ability | 11.24 | 10.78 | 21 | 84826 | 4490 | 63399685 |
Inappropriate schedule of product administration | 11.23 | 10.78 | 87 | 84760 | 103878 | 63300297 |
Respiratory disorder | 11.21 | 10.78 | 22 | 84825 | 39060 | 63365115 |
Haemorrhoids | 11.14 | 10.78 | 8 | 84839 | 22142 | 63382033 |
Poor venous access | 11.11 | 10.78 | 3 | 84844 | 14782 | 63389393 |
Cytomegalovirus mucocutaneous ulcer | 11.04 | 10.78 | 3 | 84844 | 18 | 63404157 |
Personality change | 11.04 | 10.78 | 27 | 84820 | 6946 | 63397229 |
Haemorrhage | 11.04 | 10.78 | 43 | 84804 | 60979 | 63343196 |
Visual field defect | 11.03 | 10.78 | 26 | 84821 | 6535 | 63397640 |
Hallucination, visual | 10.97 | 10.78 | 53 | 84794 | 19245 | 63384930 |
Sinus disorder | 10.93 | 10.78 | 10 | 84837 | 24543 | 63379632 |
Blood pressure systolic increased | 10.93 | 10.78 | 30 | 84817 | 47367 | 63356808 |
Unresponsive to stimuli | 10.89 | 10.78 | 80 | 84767 | 33736 | 63370439 |
Trismus | 10.84 | 10.78 | 19 | 84828 | 3866 | 63400309 |
Neurological examination abnormal | 10.83 | 10.78 | 6 | 84841 | 284 | 63403891 |
Logorrhoea | 10.82 | 10.78 | 15 | 84832 | 2495 | 63401680 |
Leukopenia | 10.81 | 10.78 | 154 | 84693 | 77136 | 63327039 |
Laboratory test abnormal | 10.80 | 10.78 | 12 | 84835 | 26900 | 63377275 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1062.52 | 11.52 | 1104 | 60405 | 103753 | 34791669 |
Drug reaction with eosinophilia and systemic symptoms | 762.29 | 11.52 | 557 | 60952 | 32455 | 34862967 |
Generalised tonic-clonic seizure | 369.89 | 11.52 | 303 | 61206 | 20871 | 34874551 |
Epilepsy | 353.44 | 11.52 | 297 | 61212 | 21198 | 34874224 |
Anticonvulsant drug level increased | 347.10 | 11.52 | 124 | 61385 | 1492 | 34893930 |
Status epilepticus | 297.99 | 11.52 | 216 | 61293 | 12398 | 34883024 |
Stevens-Johnson syndrome | 262.88 | 11.52 | 236 | 61273 | 18403 | 34877019 |
Aggression | 251.40 | 11.52 | 326 | 61183 | 38638 | 34856784 |
Drug interaction | 248.32 | 11.52 | 916 | 60593 | 225030 | 34670392 |
Ataxia | 222.70 | 11.52 | 189 | 61320 | 13664 | 34881758 |
Death | 206.17 | 11.52 | 239 | 61270 | 397810 | 34497612 |
Drug eruption | 190.78 | 11.52 | 204 | 61305 | 19694 | 34875728 |
Gamma-glutamyltransferase increased | 172.22 | 11.52 | 234 | 61275 | 28997 | 34866425 |
Somnolence | 165.76 | 11.52 | 500 | 61009 | 110616 | 34784806 |
Toxicity to various agents | 155.78 | 11.52 | 731 | 60778 | 199631 | 34695791 |
Nystagmus | 154.81 | 11.52 | 99 | 61410 | 4616 | 34890806 |
Febrile neutropenia | 150.78 | 11.52 | 29 | 61480 | 136820 | 34758602 |
Diarrhoea | 144.20 | 11.52 | 294 | 61215 | 389618 | 34505804 |
Coordination abnormal | 143.17 | 11.52 | 114 | 61395 | 7530 | 34887892 |
Anticonvulsant drug level above therapeutic | 130.28 | 11.52 | 48 | 61461 | 634 | 34894788 |
Partial seizures | 129.76 | 11.52 | 89 | 61420 | 4671 | 34890751 |
Dyspnoea | 129.39 | 11.52 | 296 | 61213 | 376486 | 34518936 |
Overdose | 127.57 | 11.52 | 401 | 61108 | 90658 | 34804764 |
Multiple-drug resistance | 124.35 | 11.52 | 90 | 61419 | 5149 | 34890273 |
Petit mal epilepsy | 117.16 | 11.52 | 71 | 61438 | 3007 | 34892415 |
Electroencephalogram abnormal | 115.01 | 11.52 | 65 | 61444 | 2413 | 34893009 |
Sopor | 112.06 | 11.52 | 122 | 61387 | 12014 | 34883408 |
Sudden unexplained death in epilepsy | 111.48 | 11.52 | 39 | 61470 | 439 | 34894983 |
Eosinophilia | 111.32 | 11.52 | 180 | 61329 | 26042 | 34869380 |
Lymphocyte stimulation test positive | 109.84 | 11.52 | 43 | 61466 | 677 | 34894745 |
Hyponatraemia | 108.39 | 11.52 | 356 | 61153 | 82335 | 34813087 |
Rash maculo-papular | 107.02 | 11.52 | 185 | 61324 | 28266 | 34867156 |
Acute kidney injury | 105.87 | 11.52 | 238 | 61271 | 304750 | 34590672 |
Psychogenic seizure | 101.33 | 11.52 | 34 | 61475 | 334 | 34895088 |
Focal dyscognitive seizures | 100.64 | 11.52 | 49 | 61460 | 1332 | 34894090 |
Pneumonia | 98.75 | 11.52 | 319 | 61190 | 362308 | 34533114 |
Human herpes virus 6 serology positive | 95.95 | 11.52 | 26 | 61483 | 111 | 34895311 |
Irritability | 94.77 | 11.52 | 162 | 61347 | 24528 | 34870894 |
Abnormal behaviour | 92.14 | 11.52 | 161 | 61348 | 24808 | 34870614 |
Anaemia | 92.03 | 11.52 | 169 | 61340 | 233166 | 34662256 |
Drug level increased | 91.51 | 11.52 | 150 | 61359 | 21946 | 34873476 |
Agitation | 90.88 | 11.52 | 264 | 61245 | 57135 | 34838287 |
Toxic epidermal necrolysis | 89.71 | 11.52 | 147 | 61362 | 21499 | 34873923 |
Drug level decreased | 88.85 | 11.52 | 88 | 61421 | 7758 | 34887664 |
Trigeminal neuralgia | 87.74 | 11.52 | 43 | 61466 | 1186 | 34894236 |
Lymphadenopathy | 86.74 | 11.52 | 169 | 61340 | 28294 | 34867128 |
Dysarthria | 85.45 | 11.52 | 189 | 61320 | 34593 | 34860829 |
Diplopia | 81.76 | 11.52 | 123 | 61386 | 16720 | 34878702 |
Drug resistance | 79.07 | 11.52 | 154 | 61355 | 25773 | 34869649 |
Sepsis | 77.54 | 11.52 | 108 | 61401 | 166453 | 34728969 |
Anticonvulsant drug level decreased | 77.34 | 11.52 | 38 | 61471 | 1054 | 34894368 |
Autism spectrum disorder | 77.34 | 11.52 | 49 | 61460 | 2247 | 34893175 |
Arthralgia | 75.48 | 11.52 | 114 | 61395 | 169927 | 34725495 |
Gastric lavage | 74.82 | 11.52 | 14 | 61495 | 0 | 34895422 |
Loss of consciousness | 74.09 | 11.52 | 315 | 61194 | 82352 | 34813070 |
Cross sensitivity reaction | 74.05 | 11.52 | 40 | 61469 | 1357 | 34894065 |
Hyperammonaemia | 73.19 | 11.52 | 72 | 61437 | 6295 | 34889127 |
Rash | 72.32 | 11.52 | 652 | 60857 | 222100 | 34673322 |
Toxic skin eruption | 71.40 | 11.52 | 94 | 61415 | 11291 | 34884131 |
Cardiac failure congestive | 70.66 | 11.52 | 29 | 61480 | 83241 | 34812181 |
Dermatitis exfoliative | 70.65 | 11.52 | 72 | 61437 | 6567 | 34888855 |
Dysmorphism | 69.89 | 11.52 | 52 | 61457 | 3104 | 34892318 |
Myocardial infarction | 68.72 | 11.52 | 67 | 61442 | 121018 | 34774404 |
Atrial fibrillation | 66.86 | 11.52 | 70 | 61439 | 122323 | 34773099 |
Lymphocyte morphology abnormal | 65.61 | 11.52 | 27 | 61482 | 487 | 34894935 |
Fatigue | 64.84 | 11.52 | 385 | 61124 | 370268 | 34525154 |
Dyskinesia | 63.38 | 11.52 | 129 | 61380 | 22284 | 34873138 |
Decreased eye contact | 63.18 | 11.52 | 26 | 61483 | 469 | 34894953 |
Altered state of consciousness | 62.66 | 11.52 | 130 | 61379 | 22763 | 34872659 |
Hypospadias | 62.65 | 11.52 | 49 | 61460 | 3152 | 34892270 |
Bruxism | 58.37 | 11.52 | 37 | 61472 | 1698 | 34893724 |
Aura | 57.78 | 11.52 | 22 | 61487 | 320 | 34895102 |
Intentional self-injury | 57.70 | 11.52 | 94 | 61415 | 13677 | 34881745 |
Gait disturbance | 57.62 | 11.52 | 299 | 61210 | 84841 | 34810581 |
Oppositional defiant disorder | 57.31 | 11.52 | 25 | 61484 | 524 | 34894898 |
Coma | 56.55 | 11.52 | 193 | 61316 | 45485 | 34849937 |
Suicide attempt | 56.30 | 11.52 | 174 | 61335 | 38942 | 34856480 |
Malignant neoplasm progression | 55.64 | 11.52 | 44 | 61465 | 88002 | 34807420 |
Oral mucosa erosion | 54.81 | 11.52 | 29 | 61480 | 943 | 34894479 |
Joint swelling | 53.89 | 11.52 | 19 | 61490 | 59871 | 34835551 |
Gaze palsy | 53.86 | 11.52 | 35 | 61474 | 1677 | 34893745 |
Off label use | 52.14 | 11.52 | 480 | 61029 | 419044 | 34476378 |
Foetal exposure during pregnancy | 51.63 | 11.52 | 166 | 61343 | 37935 | 34857487 |
Prostate cancer | 51.62 | 11.52 | 5 | 61504 | 39644 | 34855778 |
Back pain | 50.83 | 11.52 | 85 | 61424 | 121704 | 34773718 |
Excessive eye blinking | 50.48 | 11.52 | 23 | 61486 | 536 | 34894886 |
Gastrointestinal haemorrhage | 50.13 | 11.52 | 49 | 61460 | 88428 | 34806994 |
Mucosal erosion | 49.92 | 11.52 | 26 | 61483 | 818 | 34894604 |
Rheumatoid arthritis | 49.32 | 11.52 | 5 | 61504 | 38233 | 34857189 |
Psychomotor retardation | 49.04 | 11.52 | 45 | 61464 | 3605 | 34891817 |
Depressed level of consciousness | 47.85 | 11.52 | 175 | 61334 | 42666 | 34852756 |
Paraplegia | 47.35 | 11.52 | 40 | 61469 | 2871 | 34892551 |
Exposure during pregnancy | 47.33 | 11.52 | 68 | 61441 | 8866 | 34886556 |
Mania | 46.93 | 11.52 | 70 | 61439 | 9441 | 34885981 |
Skin test positive | 46.26 | 11.52 | 19 | 61490 | 341 | 34895081 |
Balance disorder | 46.20 | 11.52 | 167 | 61342 | 40487 | 34854935 |
Neuropathy peripheral | 46.15 | 11.52 | 47 | 61462 | 83216 | 34812206 |
Erythema multiforme | 46.07 | 11.52 | 66 | 61443 | 8583 | 34886839 |
Hepatic adenoma | 45.94 | 11.52 | 12 | 61497 | 43 | 34895379 |
Vertigo | 45.85 | 11.52 | 123 | 61386 | 25413 | 34870009 |
Neuroleptic malignant syndrome | 45.79 | 11.52 | 99 | 61410 | 17835 | 34877587 |
Cerebellar syndrome | 45.54 | 11.52 | 36 | 61473 | 2352 | 34893070 |
Plasmapheresis | 44.40 | 11.52 | 18 | 61491 | 312 | 34895110 |
Intentional overdose | 44.31 | 11.52 | 173 | 61336 | 43501 | 34851921 |
Hypotension | 44.29 | 11.52 | 220 | 61289 | 221429 | 34673993 |
Choreoathetosis | 44.28 | 11.52 | 26 | 61483 | 1038 | 34894384 |
Drug level below therapeutic | 44.25 | 11.52 | 52 | 61457 | 5563 | 34889859 |
Alanine aminotransferase increased | 44.18 | 11.52 | 268 | 61241 | 80547 | 34814875 |
Inappropriate antidiuretic hormone secretion | 44.16 | 11.52 | 80 | 61429 | 12673 | 34882749 |
Homicidal ideation | 43.92 | 11.52 | 37 | 61472 | 2645 | 34892777 |
Head circumference abnormal | 43.60 | 11.52 | 11 | 61498 | 33 | 34895389 |
Conjunctival hyperaemia | 43.22 | 11.52 | 35 | 61474 | 2367 | 34893055 |
Human herpesvirus 6 infection | 43.22 | 11.52 | 33 | 61476 | 2048 | 34893374 |
Dehydration | 42.87 | 11.52 | 104 | 61405 | 129865 | 34765557 |
Hepatic function abnormal | 42.81 | 11.52 | 173 | 61336 | 44190 | 34851232 |
Sedation | 42.68 | 11.52 | 106 | 61403 | 20900 | 34874522 |
Congenital nail disorder | 42.65 | 11.52 | 11 | 61498 | 37 | 34895385 |
Renal failure | 42.64 | 11.52 | 105 | 61404 | 130452 | 34764970 |
Product dose omission issue | 42.55 | 11.52 | 92 | 61417 | 119619 | 34775803 |
Speech disorder | 42.42 | 11.52 | 120 | 61389 | 25566 | 34869856 |
Product complaint | 42.25 | 11.52 | 52 | 61457 | 5838 | 34889584 |
Psychotic disorder | 42.12 | 11.52 | 116 | 61393 | 24336 | 34871086 |
Nausea | 42.12 | 11.52 | 389 | 61120 | 339519 | 34555903 |
Psychomotor hyperactivity | 42.11 | 11.52 | 67 | 61442 | 9555 | 34885867 |
Hyperammonaemic encephalopathy | 42.11 | 11.52 | 34 | 61475 | 2290 | 34893132 |
Weight decreased | 41.86 | 11.52 | 164 | 61345 | 176137 | 34719285 |
COVID-19 | 41.60 | 11.52 | 45 | 61464 | 77505 | 34817917 |
Tonic convulsion | 41.38 | 11.52 | 26 | 61483 | 1175 | 34894247 |
Drug ineffective | 41.10 | 11.52 | 1072 | 60437 | 455679 | 34439743 |
Abdominal pain | 40.91 | 11.52 | 149 | 61360 | 163469 | 34731953 |
Altered pitch perception | 40.50 | 11.52 | 9 | 61500 | 12 | 34895410 |
Skin exfoliation | 40.37 | 11.52 | 123 | 61386 | 27309 | 34868113 |
Intentional product use issue | 40.22 | 11.52 | 28 | 61481 | 59788 | 34835634 |
Disease progression | 40.14 | 11.52 | 81 | 61428 | 107996 | 34787426 |
Chest pain | 39.81 | 11.52 | 104 | 61405 | 126658 | 34768764 |
Aspartate aminotransferase increased | 39.75 | 11.52 | 229 | 61280 | 67554 | 34827868 |
Face oedema | 39.57 | 11.52 | 72 | 61437 | 11444 | 34883978 |
Middle insomnia | 39.35 | 11.52 | 54 | 61455 | 6748 | 34888674 |
Neonatal pneumonia | 39.27 | 11.52 | 13 | 61496 | 122 | 34895300 |
Hospitalisation | 39.11 | 11.52 | 26 | 61483 | 56876 | 34838546 |
Posture abnormal | 38.98 | 11.52 | 32 | 61477 | 2207 | 34893215 |
Cognitive disorder | 38.86 | 11.52 | 125 | 61384 | 28568 | 34866854 |
Anticonvulsant drug level below therapeutic | 38.46 | 11.52 | 20 | 61489 | 627 | 34894795 |
Asterixis | 38.28 | 11.52 | 25 | 61484 | 1208 | 34894214 |
Hypotonia | 37.61 | 11.52 | 57 | 61452 | 7796 | 34887626 |
Postictal psychosis | 37.59 | 11.52 | 14 | 61495 | 191 | 34895231 |
Coronary artery disease | 37.57 | 11.52 | 19 | 61490 | 48286 | 34847136 |
Product substitution issue | 37.10 | 11.52 | 65 | 61444 | 10030 | 34885392 |
Neonatal hypotension | 36.95 | 11.52 | 13 | 61496 | 149 | 34895273 |
Ascites | 36.70 | 11.52 | 18 | 61491 | 46553 | 34848869 |
Roseolovirus test positive | 36.69 | 11.52 | 11 | 61498 | 72 | 34895350 |
Peripheral swelling | 36.20 | 11.52 | 49 | 61460 | 76492 | 34818930 |
Simple partial seizures | 36.13 | 11.52 | 15 | 61494 | 277 | 34895145 |
Lip erosion | 35.93 | 11.52 | 19 | 61490 | 617 | 34894805 |
Apathy | 35.61 | 11.52 | 52 | 61457 | 6880 | 34888542 |
Oedema peripheral | 35.59 | 11.52 | 101 | 61408 | 119711 | 34775711 |
Pain | 35.45 | 11.52 | 213 | 61296 | 204462 | 34690960 |
Neutropenia | 35.22 | 11.52 | 149 | 61360 | 156629 | 34738793 |
Blood lactate dehydrogenase increased | 34.69 | 11.52 | 104 | 61405 | 22886 | 34872536 |
Agnosia | 34.23 | 11.52 | 10 | 61499 | 59 | 34895363 |
Intellectual disability | 34.08 | 11.52 | 24 | 61485 | 1314 | 34894108 |
Bradyphrenia | 33.84 | 11.52 | 42 | 61467 | 4756 | 34890666 |
Disturbance in attention | 33.31 | 11.52 | 111 | 61398 | 25834 | 34869588 |
Delusion | 32.54 | 11.52 | 70 | 61439 | 12565 | 34882857 |
Radiation inflammation | 32.21 | 11.52 | 20 | 61489 | 885 | 34894537 |
Completed suicide | 32.07 | 11.52 | 288 | 61221 | 97880 | 34797542 |
Septic shock | 31.97 | 11.52 | 48 | 61461 | 71786 | 34823636 |
Crying | 31.61 | 11.52 | 45 | 61464 | 5817 | 34889605 |
Eosinophil count increased | 31.25 | 11.52 | 55 | 61454 | 8517 | 34886905 |
Lymphocytic infiltration | 31.15 | 11.52 | 18 | 61491 | 697 | 34894725 |
Pain in extremity | 31.09 | 11.52 | 116 | 61393 | 126397 | 34769025 |
Cardiac failure | 30.88 | 11.52 | 72 | 61437 | 91176 | 34804246 |
Postictal paralysis | 30.78 | 11.52 | 13 | 61496 | 251 | 34895171 |
Hyperkinesia | 30.21 | 11.52 | 25 | 61484 | 1743 | 34893679 |
Epistaxis | 29.93 | 11.52 | 35 | 61474 | 58216 | 34837206 |
Blood alkaline phosphatase increased | 29.61 | 11.52 | 121 | 61388 | 31054 | 34864368 |
Myoclonus | 29.59 | 11.52 | 74 | 61435 | 14651 | 34880771 |
Foetal anticonvulsant syndrome | 29.56 | 11.52 | 21 | 61488 | 1166 | 34894256 |
Infusion related reaction | 29.33 | 11.52 | 30 | 61479 | 53027 | 34842395 |
Plasma cell myeloma | 29.17 | 11.52 | 19 | 61490 | 42018 | 34853404 |
Microcephaly | 29.06 | 11.52 | 18 | 61491 | 793 | 34894629 |
Bradykinesia | 28.95 | 11.52 | 35 | 61474 | 3858 | 34891564 |
Chest discomfort | 28.84 | 11.52 | 32 | 61477 | 54498 | 34840924 |
Thrombosis | 28.50 | 11.52 | 28 | 61481 | 50430 | 34844992 |
Psychiatric symptom | 28.46 | 11.52 | 33 | 61476 | 3480 | 34891942 |
Mood altered | 28.29 | 11.52 | 54 | 61455 | 8898 | 34886524 |
Dysmetria | 28.26 | 11.52 | 16 | 61493 | 596 | 34894826 |
Temporal lobe epilepsy | 28.11 | 11.52 | 11 | 61498 | 173 | 34895249 |
Acute myocardial infarction | 27.90 | 11.52 | 32 | 61477 | 53687 | 34841735 |
Non-24-hour sleep-wake disorder | 27.50 | 11.52 | 7 | 61502 | 22 | 34895400 |
Infection | 27.47 | 11.52 | 76 | 61433 | 90839 | 34804583 |
Myalgia | 27.17 | 11.52 | 68 | 61441 | 84042 | 34811380 |
Erythema | 26.75 | 11.52 | 256 | 61253 | 88524 | 34806898 |
Pulmonary pain | 26.73 | 11.52 | 20 | 61489 | 1204 | 34894218 |
Skin erosion | 26.65 | 11.52 | 25 | 61484 | 2060 | 34893362 |
Clumsiness | 26.54 | 11.52 | 23 | 61486 | 1709 | 34893713 |
Decreased appetite | 26.31 | 11.52 | 178 | 61331 | 166214 | 34729208 |
Hyperexplexia | 25.62 | 11.52 | 7 | 61502 | 31 | 34895391 |
Meningocele | 25.44 | 11.52 | 7 | 61502 | 32 | 34895390 |
Low birth weight baby | 25.37 | 11.52 | 48 | 61461 | 7857 | 34887565 |
Epileptic aura | 25.17 | 11.52 | 6 | 61503 | 13 | 34895409 |
Arthritis | 24.87 | 11.52 | 12 | 61497 | 31334 | 34864088 |
Mucosal inflammation | 24.76 | 11.52 | 19 | 61490 | 38603 | 34856819 |
Pleural effusion | 24.76 | 11.52 | 68 | 61441 | 81478 | 34813944 |
Frontotemporal dementia | 24.73 | 11.52 | 11 | 61498 | 242 | 34895180 |
Partial seizures with secondary generalisation | 24.72 | 11.52 | 12 | 61497 | 324 | 34895098 |
Trismus | 24.64 | 11.52 | 26 | 61483 | 2469 | 34892953 |
Dyspraxia | 24.53 | 11.52 | 13 | 61496 | 424 | 34894998 |
Constipation | 24.51 | 11.52 | 141 | 61368 | 136841 | 34758581 |
Renal phospholipidosis | 24.38 | 11.52 | 5 | 61504 | 3 | 34895419 |
Epileptic psychosis | 24.30 | 11.52 | 6 | 61503 | 16 | 34895406 |
Genital erosion | 24.24 | 11.52 | 11 | 61498 | 254 | 34895168 |
Hyperdynamic left ventricle | 24.12 | 11.52 | 10 | 61499 | 184 | 34895238 |
Developmental delay | 24.06 | 11.52 | 27 | 61482 | 2748 | 34892674 |
Cellulitis | 23.93 | 11.52 | 35 | 61474 | 52916 | 34842506 |
Pneumonitis | 23.93 | 11.52 | 15 | 61494 | 33863 | 34861559 |
Pneumonia aspiration | 23.54 | 11.52 | 140 | 61369 | 41763 | 34853659 |
Gingival atrophy | 23.32 | 11.52 | 7 | 61502 | 46 | 34895376 |
Thinking abnormal | 23.18 | 11.52 | 40 | 61469 | 6097 | 34889325 |
Personality disorder | 23.12 | 11.52 | 18 | 61491 | 1150 | 34894272 |
Epidermal necrosis | 23.11 | 11.52 | 13 | 61496 | 478 | 34894944 |
Accidental overdose | 23.10 | 11.52 | 83 | 61426 | 20057 | 34875365 |
Liver disorder | 23.07 | 11.52 | 117 | 61392 | 32880 | 34862542 |
Apgar score low | 22.67 | 11.52 | 16 | 61493 | 879 | 34894543 |
Facial pain | 22.32 | 11.52 | 30 | 61479 | 3674 | 34891748 |
Congenital cystic lung | 22.31 | 11.52 | 10 | 61499 | 224 | 34895198 |
Diabetic neuropathy | 22.31 | 11.52 | 32 | 61477 | 4165 | 34891257 |
Schizophrenia | 22.30 | 11.52 | 48 | 61461 | 8618 | 34886804 |
Change in seizure presentation | 22.25 | 11.52 | 9 | 61500 | 155 | 34895267 |
Loose associations | 22.24 | 11.52 | 7 | 61502 | 55 | 34895367 |
Water intoxication | 21.98 | 11.52 | 12 | 61497 | 416 | 34895006 |
Full blood count decreased | 21.75 | 11.52 | 3 | 61506 | 18085 | 34877337 |
Neurodevelopmental disorder | 21.74 | 11.52 | 12 | 61497 | 425 | 34894997 |
Wrong patient received product | 21.62 | 11.52 | 25 | 61484 | 2629 | 34892793 |
Blood pressure increased | 21.49 | 11.52 | 81 | 61428 | 88021 | 34807401 |
Tremor | 21.45 | 11.52 | 231 | 61278 | 82356 | 34813066 |
Sinusitis | 21.13 | 11.52 | 25 | 61484 | 41377 | 34854045 |
Drowning | 21.05 | 11.52 | 12 | 61497 | 453 | 34894969 |
Hepatosplenomegaly | 21.02 | 11.52 | 31 | 61478 | 4138 | 34891284 |
Affect lability | 20.94 | 11.52 | 29 | 61480 | 3654 | 34891768 |
Atonic seizures | 20.87 | 11.52 | 10 | 61499 | 262 | 34895160 |
Abdominal distension | 20.72 | 11.52 | 45 | 61464 | 58447 | 34836975 |
Hyperpyrexia | 20.62 | 11.52 | 25 | 61484 | 2763 | 34892659 |
Sinus arrest | 20.60 | 11.52 | 20 | 61489 | 1720 | 34893702 |
Bone marrow failure | 20.60 | 11.52 | 13 | 61496 | 29240 | 34866182 |
Hangover | 20.38 | 11.52 | 16 | 61493 | 1035 | 34894387 |
Acute generalised exanthematous pustulosis | 20.35 | 11.52 | 40 | 61469 | 6736 | 34888686 |
Congenital anomaly | 20.34 | 11.52 | 18 | 61491 | 1375 | 34894047 |
Medication error | 20.28 | 11.52 | 94 | 61415 | 25471 | 34869951 |
Rash morbilliform | 20.15 | 11.52 | 26 | 61483 | 3061 | 34892361 |
Rash pustular | 20.11 | 11.52 | 35 | 61474 | 5373 | 34890049 |
Personality change | 20.08 | 11.52 | 34 | 61475 | 5105 | 34890317 |
Depressed mood | 19.97 | 11.52 | 77 | 61432 | 19240 | 34876182 |
Emotional disorder | 19.97 | 11.52 | 36 | 61473 | 5680 | 34889742 |
Chronic kidney disease | 19.86 | 11.52 | 26 | 61483 | 41184 | 34854238 |
Antisocial behaviour | 19.77 | 11.52 | 11 | 61498 | 396 | 34895026 |
Papule | 19.76 | 11.52 | 30 | 61479 | 4109 | 34891313 |
Haemoglobin decreased | 19.68 | 11.52 | 128 | 61381 | 120644 | 34774778 |
Blister | 19.60 | 11.52 | 86 | 61423 | 22772 | 34872650 |
Hypoventilation | 19.59 | 11.52 | 27 | 61482 | 3387 | 34892035 |
Guillain-Barre syndrome | 19.59 | 11.52 | 37 | 61472 | 6050 | 34889372 |
Micrognathia | 19.51 | 11.52 | 10 | 61499 | 304 | 34895118 |
Haemorrhage | 19.48 | 11.52 | 38 | 61471 | 51332 | 34844090 |
Dysphagia | 19.34 | 11.52 | 181 | 61328 | 62200 | 34833222 |
Gout | 19.32 | 11.52 | 5 | 61504 | 19248 | 34876174 |
Enanthema | 19.25 | 11.52 | 11 | 61498 | 417 | 34895005 |
Condition aggravated | 19.20 | 11.52 | 458 | 61051 | 191738 | 34703684 |
Anger | 19.11 | 11.52 | 55 | 61454 | 11829 | 34883593 |
Pyrexia | 19.11 | 11.52 | 741 | 60768 | 332272 | 34563150 |
Suicidal ideation | 19.00 | 11.52 | 129 | 61380 | 40259 | 34855163 |
Communication disorder | 18.91 | 11.52 | 23 | 61486 | 2551 | 34892871 |
Lymphocytosis | 18.89 | 11.52 | 23 | 61486 | 2554 | 34892868 |
Bone metabolism disorder | 18.68 | 11.52 | 9 | 61500 | 239 | 34895183 |
Cardiogenic shock | 18.51 | 11.52 | 12 | 61497 | 26606 | 34868816 |
Hyporeflexia | 18.38 | 11.52 | 20 | 61489 | 1967 | 34893455 |
Stomatitis | 18.34 | 11.52 | 29 | 61480 | 42485 | 34852937 |
Extrapyramidal disorder | 18.24 | 11.52 | 57 | 61452 | 12823 | 34882599 |
Tracheo-oesophageal fistula | 18.21 | 11.52 | 11 | 61498 | 463 | 34894959 |
Oculomucocutaneous syndrome | 18.19 | 11.52 | 8 | 61501 | 171 | 34895251 |
Angina pectoris | 18.18 | 11.52 | 17 | 61492 | 31346 | 34864076 |
Perseveration | 18.07 | 11.52 | 7 | 61502 | 107 | 34895315 |
Drug withdrawal syndrome | 18.06 | 11.52 | 76 | 61433 | 19758 | 34875664 |
Respiratory disorder neonatal | 17.93 | 11.52 | 18 | 61491 | 1612 | 34893810 |
Cerebellar ataxia | 17.92 | 11.52 | 15 | 61494 | 1063 | 34894359 |
Hypomagnesaemia | 17.90 | 11.52 | 8 | 61501 | 21843 | 34873579 |
Osteoarthritis | 17.80 | 11.52 | 7 | 61502 | 20635 | 34874787 |
Hypertension | 17.76 | 11.52 | 154 | 61355 | 136289 | 34759133 |
Fluid retention | 17.53 | 11.52 | 13 | 61496 | 26874 | 34868548 |
General physical health deterioration | 17.50 | 11.52 | 143 | 61366 | 128126 | 34767296 |
Injection site pain | 17.41 | 11.52 | 26 | 61483 | 38979 | 34856443 |
Contraindicated product administered | 17.38 | 11.52 | 8 | 61501 | 21473 | 34873949 |
Osteonecrosis of jaw | 17.28 | 11.52 | 5 | 61504 | 17884 | 34877538 |
Ultrasound liver abnormal | 17.23 | 11.52 | 7 | 61502 | 122 | 34895300 |
Rash erythematous | 17.06 | 11.52 | 88 | 61421 | 24889 | 34870533 |
Motor developmental delay | 17.06 | 11.52 | 12 | 61497 | 656 | 34894766 |
Dysgeusia | 17.03 | 11.52 | 13 | 61496 | 26484 | 34868938 |
Strabismus | 17.03 | 11.52 | 18 | 61491 | 1713 | 34893709 |
Blood sodium decreased | 16.98 | 11.52 | 65 | 61444 | 16186 | 34879236 |
Cheilitis | 16.97 | 11.52 | 21 | 61488 | 2370 | 34893052 |
Influenza | 16.94 | 11.52 | 39 | 61470 | 49627 | 34845795 |
Diverticulitis | 16.90 | 11.52 | 7 | 61502 | 19997 | 34875425 |
Skin ulcer | 16.88 | 11.52 | 9 | 61500 | 22207 | 34873215 |
Contraindicated product prescribed | 16.86 | 11.52 | 10 | 61499 | 407 | 34895015 |
Rectal haemorrhage | 16.85 | 11.52 | 28 | 61481 | 40221 | 34855201 |
Localised infection | 16.84 | 11.52 | 5 | 61504 | 17582 | 34877840 |
Hyperkalaemia | 16.78 | 11.52 | 64 | 61445 | 69325 | 34826097 |
Bladder cancer | 16.77 | 11.52 | 4 | 61505 | 16274 | 34879148 |
Memory impairment | 16.74 | 11.52 | 132 | 61377 | 43186 | 34852236 |
Lactic acidosis | 16.69 | 11.52 | 22 | 61487 | 34750 | 34860672 |
Sedation complication | 16.64 | 11.52 | 18 | 61491 | 1759 | 34893663 |
Bacteraemia | 16.50 | 11.52 | 7 | 61502 | 19710 | 34875712 |
Hypertrophic scar | 16.38 | 11.52 | 4 | 61505 | 10 | 34895412 |
Language disorder | 16.31 | 11.52 | 20 | 61489 | 2236 | 34893186 |
Unevaluable event | 16.29 | 11.52 | 20 | 61489 | 32570 | 34862852 |
Psoriasis | 16.25 | 11.52 | 27 | 61482 | 38785 | 34856637 |
Mouth ulceration | 16.22 | 11.52 | 52 | 61457 | 11858 | 34883564 |
Atypical benign partial epilepsy | 16.03 | 11.52 | 3 | 61506 | 0 | 34895422 |
Mental disorder | 16.03 | 11.52 | 61 | 61448 | 15148 | 34880274 |
Suspiciousness | 16.02 | 11.52 | 9 | 61500 | 330 | 34895092 |
Abdominal pain upper | 15.99 | 11.52 | 68 | 61441 | 71422 | 34824000 |
Arachnoid cyst | 15.96 | 11.52 | 8 | 61501 | 232 | 34895190 |
Haemoptysis | 15.95 | 11.52 | 23 | 61486 | 34983 | 34860439 |
Body height below normal | 15.89 | 11.52 | 8 | 61501 | 234 | 34895188 |
Brain oedema | 15.88 | 11.52 | 57 | 61452 | 13764 | 34881658 |
Mental impairment | 15.86 | 11.52 | 47 | 61462 | 10275 | 34885147 |
Muscle spasms | 15.77 | 11.52 | 73 | 61436 | 74928 | 34820494 |
Haematuria | 15.75 | 11.52 | 41 | 61468 | 50025 | 34845397 |
Osteomalacia | 15.74 | 11.52 | 13 | 61496 | 904 | 34894518 |
Conduction disorder | 15.74 | 11.52 | 19 | 61490 | 2091 | 34893331 |
Potentiating drug interaction | 15.70 | 11.52 | 30 | 61479 | 4947 | 34890475 |
Labelled drug-food interaction medication error | 15.70 | 11.52 | 5 | 61504 | 41 | 34895381 |
Learning disability | 15.66 | 11.52 | 9 | 61500 | 345 | 34895077 |
Open angle glaucoma | 15.61 | 11.52 | 7 | 61502 | 157 | 34895265 |
Haematochezia | 15.51 | 11.52 | 37 | 61472 | 46497 | 34848925 |
Renal impairment | 15.47 | 11.52 | 100 | 61409 | 94413 | 34801009 |
Psychomotor skills impaired | 15.47 | 11.52 | 26 | 61483 | 3880 | 34891542 |
Premature baby | 15.43 | 11.52 | 72 | 61437 | 19561 | 34875861 |
Bone density decreased | 15.43 | 11.52 | 18 | 61491 | 1911 | 34893511 |
Cardiac disorder | 15.42 | 11.52 | 33 | 61476 | 43093 | 34852329 |
Parkinsonism | 15.42 | 11.52 | 40 | 61469 | 8098 | 34887324 |
Histiocytic necrotising lymphadenitis | 15.39 | 11.52 | 4 | 61505 | 14 | 34895408 |
Brain malformation | 15.37 | 11.52 | 7 | 61502 | 163 | 34895259 |
Xanthoma | 15.35 | 11.52 | 6 | 61503 | 94 | 34895328 |
Poriomania | 15.35 | 11.52 | 6 | 61503 | 94 | 34895328 |
Stupor | 15.31 | 11.52 | 22 | 61487 | 2869 | 34892553 |
Xanthelasma | 15.29 | 11.52 | 6 | 61503 | 95 | 34895327 |
Acute hepatic failure | 15.29 | 11.52 | 57 | 61452 | 14017 | 34881405 |
Rhesus incompatibility | 15.29 | 11.52 | 5 | 61504 | 45 | 34895377 |
Pressure of speech | 15.28 | 11.52 | 10 | 61499 | 485 | 34894937 |
Chills | 15.26 | 11.52 | 82 | 61427 | 80961 | 34814461 |
Multiple organ dysfunction syndrome | 15.24 | 11.52 | 76 | 61433 | 76490 | 34818932 |
Distractibility | 15.20 | 11.52 | 9 | 61500 | 365 | 34895057 |
Maternal drugs affecting foetus | 15.18 | 11.52 | 26 | 61483 | 3939 | 34891483 |
Prominent epicanthal folds | 15.18 | 11.52 | 7 | 61502 | 168 | 34895254 |
Torticollis | 15.06 | 11.52 | 14 | 61495 | 1140 | 34894282 |
Myoclonic epilepsy | 15.03 | 11.52 | 14 | 61495 | 1143 | 34894279 |
Hypervolaemia | 14.95 | 11.52 | 8 | 61501 | 19701 | 34875721 |
Rickets | 14.91 | 11.52 | 5 | 61504 | 49 | 34895373 |
Basal cell carcinoma | 14.88 | 11.52 | 8 | 61501 | 19650 | 34875772 |
Salivary hypersecretion | 14.87 | 11.52 | 41 | 61468 | 8603 | 34886819 |
Restlessness | 14.86 | 11.52 | 86 | 61423 | 25396 | 34870026 |
Withdrawal syndrome | 14.85 | 11.52 | 52 | 61457 | 12403 | 34883019 |
Mucosal ulceration | 14.82 | 11.52 | 13 | 61496 | 982 | 34894440 |
Oxygen saturation decreased | 14.79 | 11.52 | 47 | 61462 | 53771 | 34841651 |
Colectomy total | 14.77 | 11.52 | 7 | 61502 | 179 | 34895243 |
Ventricular tachycardia | 14.72 | 11.52 | 15 | 61494 | 26564 | 34868858 |
Gastric hypomotility | 14.64 | 11.52 | 6 | 61503 | 107 | 34895315 |
Therapeutic response unexpected | 14.58 | 11.52 | 44 | 61465 | 9713 | 34885709 |
Facial bones fracture | 14.56 | 11.52 | 20 | 61489 | 2500 | 34892922 |
Appendicitis | 14.56 | 11.52 | 4 | 61505 | 14803 | 34880619 |
Tonic clonic movements | 14.55 | 11.52 | 13 | 61496 | 1006 | 34894416 |
Nervousness | 14.49 | 11.52 | 52 | 61457 | 12554 | 34882868 |
Dystonia | 14.45 | 11.52 | 47 | 61462 | 10798 | 34884624 |
Nikolsky's sign | 14.25 | 11.52 | 7 | 61502 | 194 | 34895228 |
Cataract | 14.25 | 11.52 | 15 | 61494 | 26171 | 34869251 |
Death of relative | 14.25 | 11.52 | 4 | 61505 | 20 | 34895402 |
Dry age-related macular degeneration | 14.25 | 11.52 | 6 | 61503 | 115 | 34895307 |
Therapy cessation | 14.24 | 11.52 | 6 | 61503 | 16967 | 34878455 |
Haemorrhoids | 14.22 | 11.52 | 4 | 61505 | 14571 | 34880851 |
Sitting disability | 14.15 | 11.52 | 7 | 61502 | 197 | 34895225 |
Flatulence | 14.14 | 11.52 | 10 | 61499 | 21188 | 34874234 |
Clostridium difficile colitis | 14.13 | 11.52 | 5 | 61504 | 15725 | 34879697 |
Rash papular | 14.11 | 11.52 | 45 | 61464 | 10233 | 34885189 |
Multiple sclerosis | 13.99 | 11.52 | 34 | 61475 | 6611 | 34888811 |
Biopsy lymph gland abnormal | 13.96 | 11.52 | 3 | 61506 | 3 | 34895419 |
Kluver-Bucy syndrome | 13.96 | 11.52 | 3 | 61506 | 3 | 34895419 |
Hypoxia | 13.86 | 11.52 | 50 | 61459 | 55045 | 34840377 |
Head injury | 13.84 | 11.52 | 66 | 61443 | 18094 | 34877328 |
Conjunctivitis | 13.79 | 11.52 | 43 | 61466 | 9662 | 34885760 |
Cholinergic syndrome | 13.74 | 11.52 | 10 | 61499 | 577 | 34894845 |
Glomerular filtration rate decreased | 13.72 | 11.52 | 3 | 61506 | 12958 | 34882464 |
Genital ulceration | 13.72 | 11.52 | 9 | 61500 | 438 | 34894984 |
Onychophagia | 13.71 | 11.52 | 5 | 61504 | 64 | 34895358 |
Paresis | 13.63 | 11.52 | 18 | 61491 | 2168 | 34893254 |
Eosinophilic oesophagitis | 13.59 | 11.52 | 8 | 61501 | 321 | 34895101 |
Abulia | 13.54 | 11.52 | 10 | 61499 | 590 | 34894832 |
Acute respiratory failure | 13.43 | 11.52 | 21 | 61488 | 30907 | 34864515 |
Measles | 13.39 | 11.52 | 7 | 61502 | 222 | 34895200 |
Ammonia increased | 13.37 | 11.52 | 26 | 61483 | 4343 | 34891079 |
Maternal exposure during breast feeding | 13.37 | 11.52 | 15 | 61494 | 1526 | 34893896 |
Low set ears | 13.33 | 11.52 | 9 | 61500 | 460 | 34894962 |
Rebound effect | 13.24 | 11.52 | 22 | 61487 | 3252 | 34892170 |
Patient uncooperative | 13.23 | 11.52 | 9 | 61500 | 466 | 34894956 |
Fall | 13.19 | 11.52 | 458 | 61051 | 202427 | 34692995 |
Poverty of speech | 13.19 | 11.52 | 7 | 61502 | 229 | 34895193 |
Seizure cluster | 13.12 | 11.52 | 6 | 61503 | 141 | 34895281 |
Feeling of despair | 13.04 | 11.52 | 12 | 61497 | 965 | 34894457 |
Cryptorchism | 13.02 | 11.52 | 17 | 61492 | 2024 | 34893398 |
Cerebral palsy | 12.93 | 11.52 | 6 | 61503 | 146 | 34895276 |
Hypochloraemia | 12.90 | 11.52 | 10 | 61499 | 635 | 34894787 |
Congenital arterial malformation | 12.89 | 11.52 | 6 | 61503 | 147 | 34895275 |
Leukoplakia oral | 12.87 | 11.52 | 5 | 61504 | 77 | 34895345 |
Metastases to liver | 12.87 | 11.52 | 4 | 61505 | 13659 | 34881763 |
Paradoxical drug reaction | 12.87 | 11.52 | 22 | 61487 | 3329 | 34892093 |
Attention deficit hyperactivity disorder | 12.86 | 11.52 | 19 | 61490 | 2540 | 34892882 |
Blood glucose increased | 12.84 | 11.52 | 67 | 61442 | 66651 | 34828771 |
Tumour lysis syndrome | 12.83 | 11.52 | 7 | 61502 | 17052 | 34878370 |
Nephrolithiasis | 12.79 | 11.52 | 21 | 61488 | 30312 | 34865110 |
Subacute cutaneous lupus erythematosus | 12.78 | 11.52 | 12 | 61497 | 990 | 34894432 |
Trigeminal nerve disorder | 12.76 | 11.52 | 4 | 61505 | 31 | 34895391 |
Human herpesvirus 7 infection | 12.75 | 11.52 | 3 | 61506 | 6 | 34895416 |
Bronchitis | 12.72 | 11.52 | 35 | 61474 | 41928 | 34853494 |
Melaena | 12.71 | 11.52 | 27 | 61482 | 35353 | 34860069 |
Sinus node dysfunction | 12.66 | 11.52 | 25 | 61484 | 4224 | 34891198 |
Conjunctival disorder | 12.53 | 11.52 | 5 | 61504 | 83 | 34895339 |
Clostridium difficile infection | 12.50 | 11.52 | 9 | 61500 | 18889 | 34876533 |
Palmar-plantar erythrodysaesthesia syndrome | 12.47 | 11.52 | 7 | 61502 | 16788 | 34878634 |
Coma scale abnormal | 12.45 | 11.52 | 24 | 61485 | 3984 | 34891438 |
Blood creatinine increased | 12.44 | 11.52 | 107 | 61402 | 94869 | 34800553 |
Drug abuse | 12.39 | 11.52 | 244 | 61265 | 98852 | 34796570 |
Impulsive behaviour | 12.26 | 11.52 | 17 | 61492 | 2145 | 34893277 |
Staring | 12.23 | 11.52 | 14 | 61495 | 1456 | 34893966 |
Metastases to bone | 12.22 | 11.52 | 3 | 61506 | 11967 | 34883455 |
Blood urea decreased | 12.21 | 11.52 | 12 | 61497 | 1047 | 34894375 |
Salivary gland calculus | 12.21 | 11.52 | 5 | 61504 | 89 | 34895333 |
Treatment noncompliance | 12.19 | 11.52 | 88 | 61421 | 28012 | 34867410 |
Liver function test abnormal | 12.17 | 11.52 | 95 | 61414 | 30979 | 34864443 |
Ischaemic gastritis | 12.15 | 11.52 | 3 | 61506 | 8 | 34895414 |
Eyelid erosion | 12.15 | 11.52 | 3 | 61506 | 8 | 34895414 |
Hypercalcaemia | 12.15 | 11.52 | 6 | 61503 | 15462 | 34879960 |
Hypercapnic coma | 12.06 | 11.52 | 6 | 61503 | 171 | 34895251 |
Regressive behaviour | 12.04 | 11.52 | 4 | 61505 | 38 | 34895384 |
Cerebellar atrophy | 11.98 | 11.52 | 9 | 61500 | 545 | 34894877 |
Mycoplasma infection | 11.95 | 11.52 | 8 | 61501 | 403 | 34895019 |
Photophobia | 11.95 | 11.52 | 33 | 61476 | 6931 | 34888491 |
Cough | 11.93 | 11.52 | 189 | 61320 | 149951 | 34745471 |
Pigmentation disorder | 11.93 | 11.52 | 18 | 61491 | 2451 | 34892971 |
Drug half-life reduced | 11.89 | 11.52 | 3 | 61506 | 9 | 34895413 |
Blood lactate dehydrogenase | 11.89 | 11.52 | 3 | 61506 | 9 | 34895413 |
Wrong schedule | 11.84 | 11.52 | 6 | 61503 | 178 | 34895244 |
Multiple congenital abnormalities | 11.84 | 11.52 | 9 | 61500 | 555 | 34894867 |
Shock | 11.84 | 11.52 | 78 | 61431 | 24101 | 34871321 |
Anaplastic large cell lymphoma T- and null-cell types | 11.82 | 11.52 | 5 | 61504 | 97 | 34895325 |
Blood osmolarity decreased | 11.74 | 11.52 | 9 | 61500 | 562 | 34894860 |
Phonophobia | 11.72 | 11.52 | 6 | 61503 | 182 | 34895240 |
Trigemino-cardiac reflex | 11.57 | 11.52 | 6 | 61503 | 187 | 34895235 |
Tardive dyskinesia | 11.53 | 11.52 | 29 | 61480 | 5761 | 34889661 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 1568.00 | 10.35 | 1057 | 119405 | 63187 | 79560739 |
Seizure | 1449.75 | 10.35 | 1599 | 118863 | 187235 | 79436691 |
Toxicity to various agents | 842.70 | 10.35 | 1920 | 118542 | 419620 | 79204306 |
Generalised tonic-clonic seizure | 678.58 | 10.35 | 549 | 119913 | 43361 | 79580565 |
Drug interaction | 678.20 | 10.35 | 1750 | 118712 | 413433 | 79210493 |
Sedation complication | 630.44 | 10.35 | 355 | 120107 | 15314 | 79608612 |
Cognitive disorder | 592.88 | 10.35 | 625 | 119837 | 69301 | 79554625 |
Epilepsy | 587.64 | 10.35 | 490 | 119972 | 40370 | 79583556 |
Status epilepticus | 572.32 | 10.35 | 396 | 120066 | 24645 | 79599281 |
Balance disorder | 571.21 | 10.35 | 725 | 119737 | 98132 | 79525794 |
Anticonvulsant drug level increased | 570.58 | 10.35 | 196 | 120266 | 2457 | 79621469 |
Sedation | 567.90 | 10.35 | 533 | 119929 | 51362 | 79572564 |
Creatinine renal clearance decreased | 539.47 | 10.35 | 344 | 120118 | 18658 | 79605268 |
Depressed level of consciousness | 536.66 | 10.35 | 695 | 119767 | 95957 | 79527969 |
Stevens-Johnson syndrome | 518.76 | 10.35 | 448 | 120014 | 38718 | 79585208 |
Ataxia | 433.89 | 10.35 | 335 | 120127 | 24704 | 79599222 |
Blood calcium decreased | 427.52 | 10.35 | 367 | 120095 | 31452 | 79592474 |
Orthostatic hypotension | 387.88 | 10.35 | 451 | 120011 | 55713 | 79568213 |
Overdose | 359.90 | 10.35 | 833 | 119629 | 183373 | 79440553 |
Aggression | 356.58 | 10.35 | 412 | 120050 | 50546 | 79573380 |
Hyponatraemia | 337.31 | 10.35 | 795 | 119667 | 177053 | 79446873 |
Somnolence | 325.83 | 10.35 | 944 | 119518 | 238037 | 79385889 |
Diarrhoea | 306.83 | 10.35 | 539 | 119923 | 879950 | 78743976 |
Nystagmus | 297.86 | 10.35 | 186 | 120276 | 9718 | 79614208 |
Dyspnoea | 275.25 | 10.35 | 551 | 119911 | 856474 | 78767452 |
Petit mal epilepsy | 261.26 | 10.35 | 141 | 120321 | 5586 | 79618340 |
Psychotic disorder | 260.32 | 10.35 | 317 | 120145 | 41085 | 79582841 |
Arthralgia | 259.73 | 10.35 | 289 | 120173 | 571514 | 79052412 |
Drug eruption | 259.54 | 10.35 | 326 | 120136 | 43609 | 79580317 |
Joint swelling | 249.80 | 10.35 | 64 | 120398 | 288582 | 79335344 |
Drug level increased | 245.10 | 10.35 | 301 | 120161 | 39350 | 79584576 |
Partial seizures | 236.25 | 10.35 | 155 | 120307 | 8823 | 79615103 |
Diplopia | 231.43 | 10.35 | 269 | 120193 | 33197 | 79590729 |
Rheumatoid arthritis | 224.41 | 10.35 | 26 | 120436 | 208444 | 79415482 |
Electroencephalogram abnormal | 223.66 | 10.35 | 125 | 120337 | 5309 | 79618617 |
Focal dyscognitive seizures | 219.79 | 10.35 | 107 | 120355 | 3405 | 79620521 |
Schizophrenia | 219.48 | 10.35 | 184 | 120278 | 15256 | 79608670 |
Rash maculo-papular | 218.87 | 10.35 | 341 | 120121 | 55737 | 79568189 |
Gamma-glutamyltransferase increased | 215.51 | 10.35 | 334 | 120128 | 54346 | 79569580 |
Febrile neutropenia | 212.16 | 10.35 | 45 | 120417 | 230954 | 79392972 |
Synovitis | 211.92 | 10.35 | 3 | 120459 | 150731 | 79473195 |
Coma | 209.51 | 10.35 | 467 | 119995 | 100182 | 79523744 |
Anticonvulsant drug level above therapeutic | 207.83 | 10.35 | 75 | 120387 | 1096 | 79622830 |
Toxic epidermal necrolysis | 198.05 | 10.35 | 288 | 120174 | 44293 | 79579633 |
Sopor | 193.46 | 10.35 | 244 | 120218 | 32766 | 79591160 |
Multiple-drug resistance | 188.86 | 10.35 | 134 | 120328 | 8674 | 79615252 |
Dysarthria | 188.38 | 10.35 | 354 | 120108 | 67268 | 79556658 |
Infusion related reaction | 188.06 | 10.35 | 57 | 120405 | 230180 | 79393746 |
Eosinophilia | 185.75 | 10.35 | 282 | 120180 | 45063 | 79578863 |
Suicide attempt | 181.89 | 10.35 | 393 | 120069 | 82539 | 79541387 |
Drug level decreased | 179.09 | 10.35 | 159 | 120303 | 14243 | 79609683 |
Peripheral swelling | 175.87 | 10.35 | 94 | 120368 | 269523 | 79354403 |
Death | 167.41 | 10.35 | 381 | 120081 | 566133 | 79057793 |
Loss of consciousness | 167.23 | 10.35 | 596 | 119866 | 167347 | 79456579 |
Contraindicated product administered | 163.79 | 10.35 | 22 | 120440 | 157516 | 79466410 |
Sudden unexplained death in epilepsy | 161.94 | 10.35 | 54 | 120408 | 614 | 79623312 |
Completed suicide | 161.44 | 10.35 | 767 | 119695 | 245000 | 79378926 |
Coordination abnormal | 159.67 | 10.35 | 162 | 120300 | 17150 | 79606776 |
Fatigue | 156.32 | 10.35 | 799 | 119663 | 928928 | 78694998 |
Irritability | 153.35 | 10.35 | 245 | 120217 | 40899 | 79583027 |
Altered state of consciousness | 148.54 | 10.35 | 250 | 120212 | 43572 | 79580354 |
Abnormal behaviour | 148.45 | 10.35 | 226 | 120236 | 36195 | 79587731 |
Fall | 148.23 | 10.35 | 1249 | 119213 | 486380 | 79137546 |
Intentional overdose | 147.45 | 10.35 | 422 | 120040 | 105538 | 79518388 |
Sinusitis | 146.45 | 10.35 | 56 | 120406 | 195445 | 79428481 |
Psychogenic seizure | 145.92 | 10.35 | 67 | 120395 | 1864 | 79622062 |
Hand deformity | 142.21 | 10.35 | 3 | 120459 | 103916 | 79520010 |
Jaundice cholestatic | 139.16 | 10.35 | 124 | 120338 | 11160 | 79612766 |
Anaemia | 137.36 | 10.35 | 292 | 120170 | 444723 | 79179203 |
Drug resistance | 135.41 | 10.35 | 235 | 120227 | 41978 | 79581948 |
Inappropriate antidiuretic hormone secretion | 133.21 | 10.35 | 181 | 120281 | 26132 | 79597794 |
Acute kidney injury | 132.72 | 10.35 | 376 | 120086 | 519028 | 79104898 |
Human herpes virus 6 serology positive | 128.81 | 10.35 | 35 | 120427 | 182 | 79623744 |
Swelling | 127.99 | 10.35 | 85 | 120377 | 216626 | 79407300 |
Lymphocyte stimulation test positive | 127.24 | 10.35 | 52 | 120410 | 1081 | 79622845 |
Trigeminal neuralgia | 127.09 | 10.35 | 75 | 120387 | 3534 | 79620392 |
Hyperammonaemia | 125.23 | 10.35 | 116 | 120346 | 10977 | 79612949 |
Pericarditis | 122.79 | 10.35 | 9 | 120453 | 104227 | 79519699 |
Erythema multiforme | 122.22 | 10.35 | 142 | 120320 | 17509 | 79606417 |
Alopecia | 120.90 | 10.35 | 103 | 120359 | 231252 | 79392674 |
Hyperammonaemic encephalopathy | 119.62 | 10.35 | 80 | 120382 | 4702 | 79619224 |
Mobility decreased | 119.36 | 10.35 | 431 | 120031 | 121744 | 79502182 |
Agitation | 117.88 | 10.35 | 375 | 120087 | 99340 | 79524586 |
Cross sensitivity reaction | 117.41 | 10.35 | 72 | 120390 | 3640 | 79620286 |
Pemphigus | 116.17 | 10.35 | 9 | 120453 | 99573 | 79524353 |
Dermatitis exfoliative | 116.03 | 10.35 | 110 | 120352 | 10719 | 79613207 |
Lymphadenopathy | 115.20 | 10.35 | 251 | 120211 | 52996 | 79570930 |
Drug intolerance | 111.60 | 10.35 | 141 | 120321 | 263978 | 79359948 |
Anticonvulsant drug level decreased | 109.37 | 10.35 | 55 | 120407 | 1879 | 79622047 |
Back pain | 107.42 | 10.35 | 184 | 120278 | 303996 | 79319930 |
Abdominal discomfort | 106.81 | 10.35 | 133 | 120329 | 250594 | 79373332 |
Intentional product use issue | 105.20 | 10.35 | 49 | 120413 | 152063 | 79471863 |
Arthropathy | 103.85 | 10.35 | 70 | 120392 | 177041 | 79446885 |
Wound | 103.85 | 10.35 | 24 | 120438 | 116155 | 79507771 |
Drug abuse | 101.87 | 10.35 | 501 | 119961 | 162190 | 79461736 |
Oral mucosa erosion | 97.46 | 10.35 | 51 | 120411 | 1896 | 79622030 |
Glossodynia | 97.16 | 10.35 | 19 | 120443 | 103318 | 79520608 |
Infection | 96.03 | 10.35 | 135 | 120327 | 241577 | 79382349 |
Anticonvulsant drug level below therapeutic | 96.03 | 10.35 | 42 | 120420 | 1039 | 79622887 |
Intentional self-injury | 95.64 | 10.35 | 174 | 120288 | 32245 | 79591681 |
Pain in extremity | 92.92 | 10.35 | 264 | 120198 | 364274 | 79259652 |
Mucosal erosion | 91.81 | 10.35 | 52 | 120410 | 2266 | 79621660 |
Neuroleptic malignant syndrome | 91.76 | 10.35 | 156 | 120306 | 27403 | 79596523 |
Pneumonia | 91.59 | 10.35 | 603 | 119859 | 659643 | 78964283 |
Hepatic function abnormal | 91.06 | 10.35 | 280 | 120182 | 72827 | 79551099 |
Systemic lupus erythematosus | 90.20 | 10.35 | 35 | 120427 | 121114 | 79502812 |
Myoclonus | 90.03 | 10.35 | 155 | 120307 | 27505 | 79596421 |
Myocardial infarction | 89.03 | 10.35 | 88 | 120374 | 184041 | 79439885 |
Speech disorder | 87.84 | 10.35 | 229 | 120233 | 54216 | 79569710 |
Lymphocyte morphology abnormal | 87.64 | 10.35 | 38 | 120424 | 920 | 79623006 |
Arthritis | 87.52 | 10.35 | 32 | 120430 | 114848 | 79509078 |
Toxic skin eruption | 86.17 | 10.35 | 135 | 120327 | 22158 | 79601768 |
Gastric lavage | 85.83 | 10.35 | 20 | 120442 | 47 | 79623879 |
Myoclonic epilepsy | 85.69 | 10.35 | 47 | 120415 | 1923 | 79622003 |
Cerebellar syndrome | 85.61 | 10.35 | 69 | 120393 | 5411 | 79618515 |
Aura | 84.98 | 10.35 | 37 | 120425 | 905 | 79623021 |
Bradyphrenia | 84.61 | 10.35 | 92 | 120370 | 10548 | 79613378 |
Vertigo | 82.72 | 10.35 | 261 | 120201 | 68821 | 79555105 |
Cardiac failure congestive | 82.51 | 10.35 | 57 | 120405 | 142345 | 79481581 |
Psoriatic arthropathy | 80.79 | 10.35 | 11 | 120451 | 77988 | 79545938 |
Tonic convulsion | 80.45 | 10.35 | 47 | 120415 | 2173 | 79621753 |
Therapeutic product effect decreased | 78.43 | 10.35 | 79 | 120383 | 163784 | 79460142 |
Chest pain | 77.53 | 10.35 | 197 | 120265 | 282107 | 79341819 |
Discomfort | 77.25 | 10.35 | 47 | 120415 | 125570 | 79498356 |
Rheumatoid factor positive | 77.21 | 10.35 | 3 | 120459 | 59836 | 79564090 |
Abdominal pain | 76.30 | 10.35 | 316 | 120146 | 389253 | 79234673 |
Neuropathy peripheral | 76.15 | 10.35 | 61 | 120401 | 141244 | 79482682 |
Intellectual disability | 76.00 | 10.35 | 38 | 120424 | 1282 | 79622644 |
Impaired healing | 74.66 | 10.35 | 20 | 120442 | 87635 | 79536291 |
Face oedema | 73.04 | 10.35 | 143 | 120319 | 27993 | 79595933 |
Malignant neoplasm progression | 72.91 | 10.35 | 59 | 120403 | 135931 | 79487995 |
Human herpesvirus 6 infection | 72.22 | 10.35 | 62 | 120400 | 5308 | 79618618 |
Nausea | 72.18 | 10.35 | 1016 | 119446 | 956180 | 78667746 |
Gastrointestinal haemorrhage | 72.09 | 10.35 | 70 | 120392 | 147649 | 79476277 |
Hypotonia | 72.03 | 10.35 | 93 | 120369 | 12777 | 79611149 |
Nasopharyngitis | 71.39 | 10.35 | 175 | 120287 | 253706 | 79370220 |
Gait disturbance | 70.13 | 10.35 | 545 | 119917 | 206961 | 79416965 |
Gaze palsy | 69.75 | 10.35 | 48 | 120414 | 2957 | 79620969 |
Helicobacter infection | 69.48 | 10.35 | 11 | 120451 | 69693 | 79554233 |
Off label use | 69.07 | 10.35 | 961 | 119501 | 906254 | 78717672 |
Sepsis | 67.97 | 10.35 | 196 | 120266 | 269232 | 79354694 |
General physical health deterioration | 67.43 | 10.35 | 203 | 120259 | 275035 | 79348891 |
Temporal lobe epilepsy | 66.02 | 10.35 | 25 | 120437 | 421 | 79623505 |
Dyskinesia | 64.86 | 10.35 | 181 | 120281 | 44592 | 79579334 |
Mania | 64.31 | 10.35 | 106 | 120356 | 18154 | 79605772 |
Atrial fibrillation | 64.20 | 10.35 | 126 | 120336 | 197760 | 79426166 |
Oppositional defiant disorder | 63.39 | 10.35 | 25 | 120437 | 472 | 79623454 |
COVID-19 | 62.66 | 10.35 | 88 | 120374 | 157586 | 79466340 |
Decreased eye contact | 62.20 | 10.35 | 29 | 120433 | 836 | 79623090 |
Folliculitis | 61.87 | 10.35 | 6 | 120456 | 55374 | 79568552 |
Lip erosion | 61.80 | 10.35 | 35 | 120427 | 1525 | 79622401 |
Product dose omission issue | 61.76 | 10.35 | 181 | 120281 | 247356 | 79376570 |
Simple partial seizures | 61.39 | 10.35 | 27 | 120435 | 677 | 79623249 |
Delusion | 60.72 | 10.35 | 110 | 120352 | 20313 | 79603613 |
Osteoarthritis | 60.54 | 10.35 | 28 | 120434 | 87281 | 79536645 |
Suicidal ideation | 60.39 | 10.35 | 252 | 120210 | 76088 | 79547838 |
Abdominal pain upper | 60.04 | 10.35 | 158 | 120304 | 223661 | 79400265 |
Psychomotor hyperactivity | 59.59 | 10.35 | 98 | 120364 | 16751 | 79607175 |
Weight decreased | 59.50 | 10.35 | 305 | 120157 | 354893 | 79269033 |
Pyrexia | 59.18 | 10.35 | 1391 | 119071 | 677318 | 78946608 |
Hypersensitivity | 58.93 | 10.35 | 201 | 120261 | 262038 | 79361888 |
Disease progression | 57.57 | 10.35 | 120 | 120342 | 184242 | 79439684 |
Partial seizures with secondary generalisation | 57.25 | 10.35 | 25 | 120437 | 616 | 79623310 |
Stomatitis | 57.23 | 10.35 | 83 | 120379 | 146674 | 79477252 |
Total lung capacity increased | 56.41 | 10.35 | 38 | 120424 | 2260 | 79621666 |
Extrapyramidal disorder | 56.14 | 10.35 | 113 | 120349 | 22566 | 79601360 |
Fibromyalgia | 54.19 | 10.35 | 15 | 120447 | 64325 | 79559601 |
Skin test positive | 53.81 | 10.35 | 29 | 120433 | 1145 | 79622781 |
Choreoathetosis | 53.64 | 10.35 | 32 | 120430 | 1538 | 79622388 |
Conjunctival hyperaemia | 53.43 | 10.35 | 48 | 120414 | 4365 | 79619561 |
Product use issue | 52.64 | 10.35 | 153 | 120309 | 209669 | 79414257 |
Altered pitch perception | 51.90 | 10.35 | 11 | 120451 | 13 | 79623913 |
Irritable bowel syndrome | 51.52 | 10.35 | 15 | 120447 | 62226 | 79561700 |
Product substitution issue | 51.43 | 10.35 | 102 | 120360 | 20154 | 79603772 |
Injection site pain | 51.05 | 10.35 | 73 | 120389 | 129765 | 79494161 |
Hyporeflexia | 49.63 | 10.35 | 42 | 120420 | 3526 | 79620400 |
Atonic seizures | 49.61 | 10.35 | 24 | 120438 | 753 | 79623173 |
Skin erosion | 49.24 | 10.35 | 46 | 120416 | 4399 | 79619527 |
Pulmonary pain | 49.00 | 10.35 | 46 | 120416 | 4427 | 79619499 |
Gastrointestinal disorder | 48.75 | 10.35 | 68 | 120394 | 122137 | 79501789 |
Blood lactate dehydrogenase increased | 48.74 | 10.35 | 150 | 120312 | 39020 | 79584906 |
Change in seizure presentation | 48.71 | 10.35 | 21 | 120441 | 501 | 79623425 |
Asterixis | 48.59 | 10.35 | 37 | 120425 | 2670 | 79621256 |
Alanine aminotransferase increased | 47.39 | 10.35 | 413 | 120049 | 162157 | 79461769 |
Headache | 47.00 | 10.35 | 700 | 119762 | 653072 | 78970854 |
Apathy | 46.60 | 10.35 | 76 | 120386 | 12901 | 79611025 |
Oculomucocutaneous syndrome | 46.59 | 10.35 | 18 | 120444 | 321 | 79623605 |
Dysmorphism | 46.56 | 10.35 | 21 | 120441 | 560 | 79623366 |
Hepatic adenoma | 46.54 | 10.35 | 18 | 120444 | 322 | 79623604 |
Bronchitis | 46.08 | 10.35 | 79 | 120383 | 130565 | 79493361 |
Postictal psychosis | 46.01 | 10.35 | 15 | 120447 | 158 | 79623768 |
Chest discomfort | 45.54 | 10.35 | 87 | 120375 | 137957 | 79485969 |
Rash | 45.45 | 10.35 | 1169 | 119293 | 577189 | 79046737 |
Hypomagnesaemia | 45.43 | 10.35 | 8 | 120454 | 46903 | 79577023 |
Bruxism | 45.25 | 10.35 | 42 | 120420 | 3984 | 79619942 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 44.98 | 10.35 | 38 | 120424 | 3183 | 79620743 |
Obsessive-compulsive disorder | 44.96 | 10.35 | 50 | 120412 | 5877 | 79618049 |
Psychomotor retardation | 44.91 | 10.35 | 51 | 120411 | 6133 | 79617793 |
Contusion | 44.64 | 10.35 | 99 | 120363 | 148677 | 79475249 |
Restlessness | 44.51 | 10.35 | 163 | 120299 | 46329 | 79577597 |
Fluid retention | 44.50 | 10.35 | 25 | 120437 | 69784 | 79554142 |
Thinking abnormal | 44.47 | 10.35 | 75 | 120387 | 13086 | 79610840 |
Psychiatric symptom | 44.42 | 10.35 | 54 | 120408 | 6981 | 79616945 |
Injection site erythema | 44.36 | 10.35 | 32 | 120430 | 78165 | 79545761 |
Nikolsky's sign | 43.89 | 10.35 | 16 | 120446 | 241 | 79623685 |
Ovarian granulosa-theca cell tumour | 43.69 | 10.35 | 10 | 120452 | 21 | 79623905 |
Septic shock | 43.55 | 10.35 | 74 | 120388 | 122727 | 79501199 |
Tremor | 43.45 | 10.35 | 420 | 120042 | 169663 | 79454263 |
Hepatotoxicity | 43.37 | 10.35 | 173 | 120289 | 51179 | 79572747 |
Hospitalisation | 43.31 | 10.35 | 47 | 120415 | 94189 | 79529737 |
Shock | 42.81 | 10.35 | 154 | 120308 | 43394 | 79580532 |
Disturbance in attention | 42.79 | 10.35 | 171 | 120291 | 50630 | 79573296 |
Multiple sclerosis relapse | 42.75 | 10.35 | 161 | 120301 | 46372 | 79577554 |
Blood alkaline phosphatase increased | 42.65 | 10.35 | 200 | 120262 | 63464 | 79560462 |
Hypertension | 42.44 | 10.35 | 309 | 120153 | 330683 | 79293243 |
Behaviour disorder | 42.39 | 10.35 | 50 | 120412 | 6263 | 79617663 |
Hip arthroplasty | 42.35 | 10.35 | 3 | 120459 | 35753 | 79588173 |
Stupor | 42.18 | 10.35 | 52 | 120410 | 6820 | 79617106 |
Skin exfoliation | 42.11 | 10.35 | 180 | 120282 | 54920 | 79569006 |
Constipation | 41.93 | 10.35 | 630 | 119832 | 282420 | 79341506 |
Mood altered | 41.90 | 10.35 | 87 | 120375 | 17760 | 79606166 |
Musculoskeletal stiffness | 41.46 | 10.35 | 131 | 120331 | 174877 | 79449049 |
Cough | 40.75 | 10.35 | 356 | 120106 | 366433 | 79257493 |
Paraplegia | 40.71 | 10.35 | 44 | 120418 | 5009 | 79618917 |
Poisoning | 40.45 | 10.35 | 106 | 120356 | 25166 | 79598760 |
Paradoxical drug reaction | 40.33 | 10.35 | 52 | 120410 | 7133 | 79616793 |
Oxygen saturation decreased | 40.27 | 10.35 | 84 | 120378 | 128963 | 79494963 |
Mucosal inflammation | 40.24 | 10.35 | 33 | 120429 | 75547 | 79548379 |
Neutropenia | 40.14 | 10.35 | 262 | 120200 | 287448 | 79336478 |
Exposure during pregnancy | 40.08 | 10.35 | 276 | 120186 | 100856 | 79523070 |
Diverticulitis | 40.03 | 10.35 | 10 | 120452 | 45926 | 79578000 |
Hepatocellular injury | 39.92 | 10.35 | 160 | 120302 | 47433 | 79576493 |
Lymphocytosis | 39.82 | 10.35 | 42 | 120420 | 4651 | 79619275 |
Cholelithiasis | 39.44 | 10.35 | 171 | 120291 | 52493 | 79571433 |
Conjunctivitis | 39.27 | 10.35 | 106 | 120356 | 25609 | 79598317 |
Injection site pruritus | 39.27 | 10.35 | 8 | 120454 | 42275 | 79581651 |
Mental impairment | 39.20 | 10.35 | 88 | 120374 | 18948 | 79604978 |
Roseolovirus test positive | 38.95 | 10.35 | 14 | 120448 | 202 | 79623724 |
Histiocytosis | 38.93 | 10.35 | 10 | 120452 | 40 | 79623886 |
Accidental overdose | 38.93 | 10.35 | 140 | 120322 | 39441 | 79584485 |
Prostate cancer | 38.81 | 10.35 | 3 | 120459 | 33265 | 79590661 |
Aspartate aminotransferase increased | 38.74 | 10.35 | 349 | 120113 | 138292 | 79485634 |
Homicidal ideation | 38.73 | 10.35 | 36 | 120426 | 3421 | 79620505 |
Middle insomnia | 38.51 | 10.35 | 79 | 120383 | 15990 | 79607936 |
Hypotension | 38.14 | 10.35 | 902 | 119560 | 439415 | 79184511 |
Autism spectrum disorder | 38.12 | 10.35 | 23 | 120439 | 1129 | 79622797 |
Skin ulcer | 38.11 | 10.35 | 17 | 120445 | 54133 | 79569793 |
Postictal paralysis | 37.82 | 10.35 | 16 | 120446 | 364 | 79623562 |
Decreased appetite | 37.75 | 10.35 | 333 | 120129 | 342085 | 79281841 |
Dehydration | 37.74 | 10.35 | 220 | 120242 | 247967 | 79375959 |
Psychomotor skills impaired | 37.71 | 10.35 | 43 | 120419 | 5194 | 79618732 |
Hallucination, auditory | 37.51 | 10.35 | 91 | 120371 | 20602 | 79603324 |
Pain | 37.39 | 10.35 | 795 | 119667 | 703007 | 78920919 |
Multiple drug therapy | 37.30 | 10.35 | 38 | 120424 | 4040 | 79619886 |
Dysmetria | 37.04 | 10.35 | 22 | 120440 | 1049 | 79622877 |
Epistaxis | 37.02 | 10.35 | 70 | 120392 | 111445 | 79512481 |
Angiofibroma | 37.02 | 10.35 | 12 | 120450 | 124 | 79623802 |
Coma scale abnormal | 36.99 | 10.35 | 55 | 120407 | 8623 | 79615303 |
Epileptic psychosis | 36.64 | 10.35 | 10 | 120452 | 53 | 79623873 |
Ascites | 36.63 | 10.35 | 36 | 120426 | 75526 | 79548400 |
Cellulitis | 36.61 | 10.35 | 68 | 120394 | 108992 | 79514934 |
Hypogammaglobulinaemia | 36.29 | 10.35 | 68 | 120394 | 12883 | 79611043 |
Joint range of motion decreased | 36.16 | 10.35 | 4 | 120458 | 33278 | 79590648 |
Angiomyolipoma | 36.08 | 10.35 | 13 | 120449 | 189 | 79623737 |
Ill-defined disorder | 36.03 | 10.35 | 28 | 120434 | 65847 | 79558079 |
Hypervolaemia | 35.86 | 10.35 | 10 | 120452 | 42680 | 79581246 |
Cardiac failure | 35.22 | 10.35 | 118 | 120344 | 154724 | 79469202 |
Multiple sclerosis | 35.19 | 10.35 | 93 | 120369 | 22189 | 79601737 |
Rectal haemorrhage | 35.12 | 10.35 | 38 | 120424 | 76262 | 79547664 |
Radiation inflammation | 35.03 | 10.35 | 20 | 120442 | 885 | 79623041 |
Pleural effusion | 34.92 | 10.35 | 108 | 120354 | 145154 | 79478772 |
Plasmapheresis | 34.85 | 10.35 | 18 | 120444 | 651 | 79623275 |
Facial pain | 34.80 | 10.35 | 65 | 120397 | 12285 | 79611641 |
Pneumonitis | 34.40 | 10.35 | 25 | 120437 | 60835 | 79563091 |
Lymphocytic infiltration | 34.16 | 10.35 | 24 | 120438 | 1529 | 79622397 |
Slow speech | 34.12 | 10.35 | 29 | 120433 | 2449 | 79621477 |
Renal failure | 33.93 | 10.35 | 172 | 120290 | 200796 | 79423130 |
Nephrogenic diabetes insipidus | 33.61 | 10.35 | 27 | 120435 | 2107 | 79621819 |
Pneumonia aspiration | 33.52 | 10.35 | 194 | 120268 | 66773 | 79557153 |
Abortion induced | 33.13 | 10.35 | 47 | 120415 | 7062 | 79616864 |
Myalgia | 33.01 | 10.35 | 156 | 120306 | 185485 | 79438441 |
Osteonecrosis of jaw | 32.98 | 10.35 | 12 | 120450 | 43214 | 79580712 |
Injection site reaction | 32.98 | 10.35 | 21 | 120441 | 54764 | 79569162 |
Influenza | 32.86 | 10.35 | 94 | 120368 | 129512 | 79494414 |
Blood pressure increased | 32.85 | 10.35 | 186 | 120276 | 211174 | 79412752 |
Bursitis | 32.84 | 10.35 | 7 | 120455 | 35837 | 79588089 |
Lower respiratory tract infection | 32.55 | 10.35 | 94 | 120368 | 129126 | 79494800 |
Pregnancy with implant contraceptive | 32.50 | 10.35 | 25 | 120437 | 1831 | 79622095 |
Urinary tract infection | 32.48 | 10.35 | 262 | 120200 | 274250 | 79349676 |
Dystonia | 32.47 | 10.35 | 88 | 120374 | 21311 | 79602615 |
Adverse event | 32.42 | 10.35 | 26 | 120436 | 60188 | 79563738 |
Thrombosis | 32.35 | 10.35 | 48 | 120414 | 84052 | 79539874 |
Depressed mood | 32.25 | 10.35 | 152 | 120310 | 48328 | 79575598 |
Dyspepsia | 32.05 | 10.35 | 73 | 120389 | 108614 | 79515312 |
Palpitations | 31.97 | 10.35 | 92 | 120370 | 126518 | 79497408 |
Coronary artery disease | 31.96 | 10.35 | 31 | 120431 | 65443 | 79558483 |
Eosinophil count increased | 31.84 | 10.35 | 76 | 120386 | 17029 | 79606897 |
Sinus arrest | 31.78 | 10.35 | 33 | 120429 | 3589 | 79620337 |
Wrong patient received product | 31.71 | 10.35 | 37 | 120425 | 4581 | 79619345 |
Papule | 31.65 | 10.35 | 47 | 120415 | 7360 | 79616566 |
Aphasia | 31.44 | 10.35 | 147 | 120315 | 46585 | 79577341 |
Amyloid arthropathy | 31.35 | 10.35 | 16 | 120446 | 564 | 79623362 |
Injection site swelling | 31.32 | 10.35 | 16 | 120446 | 47116 | 79576810 |
Lennox-Gastaut syndrome | 31.27 | 10.35 | 12 | 120450 | 210 | 79623716 |
Unintended pregnancy | 31.26 | 10.35 | 34 | 120428 | 3899 | 79620027 |
Erythema | 31.13 | 10.35 | 492 | 119970 | 222798 | 79401128 |
Mental disorder | 31.02 | 10.35 | 111 | 120351 | 31191 | 79592735 |
Epidermolysis bullosa | 30.96 | 10.35 | 12 | 120450 | 216 | 79623710 |
Agnosia | 30.96 | 10.35 | 12 | 120450 | 216 | 79623710 |
Psoriasis | 30.84 | 10.35 | 55 | 120407 | 89532 | 79534394 |
Haemoglobin decreased | 30.60 | 10.35 | 203 | 120259 | 221916 | 79402010 |
Osteomalacia | 30.54 | 10.35 | 22 | 120440 | 1458 | 79622468 |
Seizure cluster | 30.54 | 10.35 | 14 | 120448 | 388 | 79623538 |
Epileptic aura | 30.14 | 10.35 | 9 | 120453 | 69 | 79623857 |
Colitis | 30.03 | 10.35 | 40 | 120422 | 73267 | 79550659 |
Medication error | 30.01 | 10.35 | 192 | 120270 | 68450 | 79555476 |
Posture abnormal | 29.99 | 10.35 | 33 | 120429 | 3833 | 79620093 |
Musculoskeletal pain | 29.98 | 10.35 | 69 | 120393 | 102285 | 79521641 |
Treatment failure | 29.88 | 10.35 | 144 | 120318 | 170342 | 79453584 |
Trismus | 29.80 | 10.35 | 39 | 120423 | 5428 | 79618498 |
Microcephaly | 29.62 | 10.35 | 11 | 120451 | 175 | 79623751 |
Chronic kidney disease | 29.29 | 10.35 | 34 | 120428 | 66120 | 79557806 |
Oedema peripheral | 29.29 | 10.35 | 242 | 120220 | 252046 | 79371880 |
Rash morbilliform | 29.16 | 10.35 | 41 | 120421 | 6109 | 79617817 |
Mouth ulceration | 29.01 | 10.35 | 125 | 120337 | 38269 | 79585657 |
Cerebral atrophy | 28.60 | 10.35 | 47 | 120415 | 8028 | 79615898 |
Oscillopsia | 28.43 | 10.35 | 11 | 120451 | 197 | 79623729 |
Self esteem decreased | 28.08 | 10.35 | 18 | 120444 | 984 | 79622942 |
Cerebellar atrophy | 28.03 | 10.35 | 19 | 120443 | 1142 | 79622784 |
Hyperkinesia | 27.87 | 10.35 | 27 | 120435 | 2702 | 79621224 |
Excessive eye blinking | 27.81 | 10.35 | 22 | 120440 | 1679 | 79622247 |
Ammonia increased | 27.80 | 10.35 | 45 | 120417 | 7590 | 79616336 |
Clostridium difficile infection | 27.62 | 10.35 | 15 | 120447 | 42670 | 79581256 |
Blood bilirubin increased | 27.58 | 10.35 | 183 | 120279 | 66049 | 79557877 |
Normal newborn | 27.57 | 10.35 | 43 | 120419 | 7029 | 79616897 |
Sarcoidosis | 27.50 | 10.35 | 47 | 120415 | 8288 | 79615638 |
Terminal insomnia | 27.22 | 10.35 | 19 | 120443 | 1198 | 79622728 |
Muscle spasms | 27.02 | 10.35 | 154 | 120308 | 174576 | 79449350 |
Drug withdrawal syndrome | 26.97 | 10.35 | 114 | 120348 | 34604 | 79589322 |
Joint stiffness | 26.93 | 10.35 | 14 | 120448 | 40816 | 79583110 |
Dry mouth | 26.87 | 10.35 | 58 | 120404 | 87961 | 79535965 |
Personality change | 26.77 | 10.35 | 52 | 120410 | 10118 | 79613808 |
Rash erythematous | 26.76 | 10.35 | 164 | 120298 | 57605 | 79566321 |
Persecutory delusion | 26.73 | 10.35 | 35 | 120427 | 4874 | 79619052 |
Lymphangioleiomyomatosis | 26.71 | 10.35 | 10 | 120452 | 163 | 79623763 |
Neonatal pneumonia | 26.68 | 10.35 | 7 | 120455 | 31 | 79623895 |
Drug withdrawal convulsions | 26.59 | 10.35 | 24 | 120438 | 2196 | 79621730 |
Blood creatine phosphokinase increased | 26.55 | 10.35 | 181 | 120281 | 65909 | 79558017 |
Stereotypy | 26.54 | 10.35 | 17 | 120445 | 928 | 79622998 |
Neonatal hypotension | 26.50 | 10.35 | 7 | 120455 | 32 | 79623894 |
Conversion disorder | 26.08 | 10.35 | 22 | 120440 | 1839 | 79622087 |
Bradykinesia | 26.08 | 10.35 | 45 | 120417 | 7998 | 79615928 |
Trigeminal nerve disorder | 26.06 | 10.35 | 10 | 120452 | 175 | 79623751 |
Hyperexplexia | 25.99 | 10.35 | 7 | 120455 | 35 | 79623891 |
Peripheral nerve decompression | 25.96 | 10.35 | 8 | 120454 | 69 | 79623857 |
Mucosal ulceration | 25.95 | 10.35 | 22 | 120440 | 1851 | 79622075 |
Drug level below therapeutic | 25.77 | 10.35 | 50 | 120412 | 9720 | 79614206 |
Dysgeusia | 25.74 | 10.35 | 29 | 120433 | 57148 | 79566778 |
Hypercalcaemia | 25.61 | 10.35 | 13 | 120449 | 38417 | 79585509 |
Cerebellar ataxia | 25.47 | 10.35 | 22 | 120440 | 1899 | 79622027 |
Hyperkalaemia | 25.45 | 10.35 | 88 | 120374 | 114310 | 79509616 |
Dizziness | 25.22 | 10.35 | 1003 | 119459 | 525438 | 79098488 |
Hepatosplenomegaly | 25.20 | 10.35 | 38 | 120424 | 6031 | 79617895 |
Blood pressure fluctuation | 25.17 | 10.35 | 39 | 120423 | 67106 | 79556820 |
Prominent epicanthal folds | 25.14 | 10.35 | 5 | 120457 | 3 | 79623923 |
Pseudolymphoma | 25.07 | 10.35 | 18 | 120444 | 1187 | 79622739 |
Acute myocardial infarction | 25.01 | 10.35 | 49 | 120413 | 76987 | 79546939 |
Haematochezia | 24.93 | 10.35 | 60 | 120402 | 87585 | 79536341 |
Non-24-hour sleep-wake disorder | 24.92 | 10.35 | 7 | 120455 | 42 | 79623884 |
Euphoric mood | 24.75 | 10.35 | 43 | 120419 | 7683 | 79616243 |
Brugada syndrome | 24.63 | 10.35 | 18 | 120444 | 1220 | 79622706 |
Hypospadias | 24.60 | 10.35 | 9 | 120453 | 137 | 79623789 |
Purpura | 24.50 | 10.35 | 75 | 120387 | 19452 | 79604474 |
Anger | 24.48 | 10.35 | 69 | 120393 | 17093 | 79606833 |
Gout | 24.45 | 10.35 | 4 | 120458 | 24745 | 79599181 |
Basal cell carcinoma | 24.38 | 10.35 | 13 | 120449 | 37362 | 79586564 |
Dysphagia | 24.35 | 10.35 | 287 | 120175 | 121849 | 79502077 |
Mydriasis | 24.26 | 10.35 | 70 | 120392 | 17573 | 79606353 |
Affect lability | 24.25 | 10.35 | 53 | 120409 | 11206 | 79612720 |
Bacteriuria | 24.21 | 10.35 | 18 | 120444 | 1253 | 79622673 |
Palmar-plantar erythrodysaesthesia syndrome | 23.95 | 10.35 | 10 | 120452 | 33124 | 79590802 |
Memory impairment | 23.82 | 10.35 | 266 | 120196 | 111468 | 79512458 |
Toxic encephalopathy | 23.68 | 10.35 | 53 | 120409 | 11387 | 79612539 |
Brain malformation | 23.64 | 10.35 | 7 | 120455 | 52 | 79623874 |
Genital erosion | 23.52 | 10.35 | 12 | 120450 | 423 | 79623503 |
Blood osmolarity decreased | 23.47 | 10.35 | 18 | 120444 | 1313 | 79622613 |
Anaphylactic reaction | 23.29 | 10.35 | 58 | 120404 | 83685 | 79540241 |
Acute generalised exanthematous pustulosis | 23.28 | 10.35 | 68 | 120394 | 17186 | 79606740 |
Illusion | 23.21 | 10.35 | 20 | 120442 | 1721 | 79622205 |
Enanthema | 23.17 | 10.35 | 15 | 120447 | 834 | 79623092 |
Cheilitis | 22.98 | 10.35 | 34 | 120428 | 5307 | 79618619 |
Mitochondrial enzyme deficiency | 22.98 | 10.35 | 6 | 120456 | 26 | 79623900 |
Hepatic cirrhosis | 22.97 | 10.35 | 12 | 120450 | 34894 | 79589032 |
Loose associations | 22.97 | 10.35 | 7 | 120455 | 58 | 79623868 |
Learning disorder | 22.96 | 10.35 | 13 | 120449 | 566 | 79623360 |
Plasma cell myeloma | 22.91 | 10.35 | 28 | 120434 | 53231 | 79570695 |
Abdominal distension | 22.79 | 10.35 | 98 | 120364 | 119552 | 79504374 |
Acute hepatic failure | 22.72 | 10.35 | 98 | 120364 | 30015 | 79593911 |
Neuromyelitis optica spectrum disorder | 22.68 | 10.35 | 16 | 120446 | 1026 | 79622900 |
Respiratory disorder neonatal | 22.65 | 10.35 | 7 | 120455 | 61 | 79623865 |
Poverty of speech | 22.65 | 10.35 | 13 | 120449 | 581 | 79623345 |
Drug-induced liver injury | 22.49 | 10.35 | 174 | 120288 | 65943 | 79557983 |
Leukocytosis | 22.47 | 10.35 | 127 | 120335 | 43328 | 79580598 |
Lethargy | 22.37 | 10.35 | 204 | 120258 | 81088 | 79542838 |
Eye movement disorder | 22.37 | 10.35 | 42 | 120420 | 7969 | 79615957 |
Haemorrhoids | 22.37 | 10.35 | 8 | 120454 | 29120 | 79594806 |
Sinus node dysfunction | 22.29 | 10.35 | 41 | 120421 | 7660 | 79616266 |
Blood pressure systolic increased | 22.27 | 10.35 | 42 | 120420 | 66944 | 79556982 |
Bone pain | 22.24 | 10.35 | 31 | 120431 | 55711 | 79568215 |
Procedural pain | 22.21 | 10.35 | 4 | 120458 | 23080 | 79600846 |
Pulmonary hypertension | 22.06 | 10.35 | 24 | 120438 | 48056 | 79575870 |
Intra-abdominal pressure increased | 22.05 | 10.35 | 10 | 120452 | 270 | 79623656 |
Communication disorder | 22.02 | 10.35 | 29 | 120433 | 4061 | 79619865 |
Congenital inguinal hernia | 22.01 | 10.35 | 5 | 120457 | 10 | 79623916 |
Opticokinetic nystagmus tests abnormal | 21.99 | 10.35 | 4 | 120458 | 0 | 79623926 |
Water intoxication | 21.93 | 10.35 | 14 | 120448 | 760 | 79623166 |
Vaccination site reaction | 21.91 | 10.35 | 8 | 120454 | 121 | 79623805 |
Renal impairment | 21.82 | 10.35 | 144 | 120318 | 157639 | 79466287 |
Therapeutic product ineffective for unapproved indication | 21.81 | 10.35 | 9 | 120453 | 192 | 79623734 |
Haemorrhage | 21.71 | 10.35 | 68 | 120394 | 91050 | 79532876 |
Febrile convulsion | 21.70 | 10.35 | 15 | 120447 | 931 | 79622995 |
Blood immunoglobulin M decreased | 21.55 | 10.35 | 17 | 120445 | 1292 | 79622634 |
Cataract | 21.50 | 10.35 | 38 | 120424 | 62082 | 79561844 |
Eyelid oedema | 21.49 | 10.35 | 57 | 120405 | 13630 | 79610296 |
Pulmonary arterial hypertension | 21.43 | 10.35 | 8 | 120454 | 28358 | 79595568 |
Clumsiness | 21.38 | 10.35 | 25 | 120437 | 3102 | 79620824 |
Metastases to liver | 21.37 | 10.35 | 8 | 120454 | 28306 | 79595620 |
Nasal congestion | 21.31 | 10.35 | 53 | 120409 | 76499 | 79547427 |
Gingival hypertrophy | 21.29 | 10.35 | 25 | 120437 | 3117 | 79620809 |
Blood sodium decreased | 21.20 | 10.35 | 103 | 120359 | 33152 | 79590774 |
Gingival atrophy | 21.20 | 10.35 | 7 | 120455 | 77 | 79623849 |
Cardiac disorder | 21.19 | 10.35 | 42 | 120420 | 65715 | 79558211 |
Nasal polyps | 21.19 | 10.35 | 39 | 120423 | 7288 | 79616638 |
Hyperpyrexia | 20.96 | 10.35 | 35 | 120427 | 6057 | 79617869 |
Developmental regression | 20.82 | 10.35 | 6 | 120456 | 40 | 79623886 |
Night sweats | 20.76 | 10.35 | 29 | 120433 | 52066 | 79571860 |
Abortion spontaneous | 20.72 | 10.35 | 94 | 120368 | 29413 | 79594513 |
Pulmonary mass | 20.61 | 10.35 | 9 | 120453 | 29025 | 79594901 |
Photophobia | 20.52 | 10.35 | 73 | 120389 | 20455 | 79603471 |
Sputum discoloured | 20.43 | 10.35 | 4 | 120458 | 21739 | 79602187 |
B-lymphocyte count decreased | 20.40 | 10.35 | 17 | 120445 | 1397 | 79622529 |
Retinal deposits | 20.39 | 10.35 | 8 | 120454 | 149 | 79623777 |
Product complaint | 20.36 | 10.35 | 55 | 120407 | 13294 | 79610632 |
Rhesus incompatibility | 20.33 | 10.35 | 5 | 120457 | 16 | 79623910 |
Central nervous system lesion | 20.31 | 10.35 | 55 | 120407 | 13313 | 79610613 |
Condition aggravated | 20.23 | 10.35 | 938 | 119524 | 500186 | 79123740 |
Ultrasound ovary abnormal | 20.21 | 10.35 | 7 | 120455 | 90 | 79623836 |
Immune thrombocytopenia | 20.15 | 10.35 | 66 | 120396 | 17739 | 79606187 |
Disorientation | 20.14 | 10.35 | 163 | 120299 | 62613 | 79561313 |
Fungal infection | 20.10 | 10.35 | 20 | 120442 | 41728 | 79582198 |
Selective IgG subclass deficiency | 20.10 | 10.35 | 5 | 120457 | 17 | 79623909 |
Salivary hypersecretion | 20.10 | 10.35 | 57 | 120405 | 14167 | 79609759 |
Dyspnoea exertional | 20.04 | 10.35 | 66 | 120396 | 87007 | 79536919 |
Device expulsion | 20.04 | 10.35 | 7 | 120455 | 25854 | 79598072 |
Withdrawal syndrome | 19.95 | 10.35 | 87 | 120375 | 26767 | 79597159 |
Ejection fraction decreased | 19.81 | 10.35 | 14 | 120448 | 34563 | 79589363 |
Tracheo-oesophageal fistula | 19.80 | 10.35 | 12 | 120450 | 594 | 79623332 |
Catatonia | 19.76 | 10.35 | 42 | 120420 | 8714 | 79615212 |
Dexamethasone suppression test positive | 19.75 | 10.35 | 4 | 120458 | 3 | 79623923 |
Brain lobectomy | 19.75 | 10.35 | 4 | 120458 | 3 | 79623923 |
Frequent bowel movements | 19.67 | 10.35 | 10 | 120452 | 29529 | 79594397 |
Brain oedema | 19.66 | 10.35 | 83 | 120379 | 25180 | 79598746 |
Bladder cancer | 19.64 | 10.35 | 3 | 120459 | 19523 | 79604403 |
Potentiating drug interaction | 19.55 | 10.35 | 42 | 120420 | 8777 | 79615149 |
Full blood count decreased | 19.54 | 10.35 | 8 | 120454 | 26811 | 79597115 |
Convulsive threshold lowered | 19.37 | 10.35 | 14 | 120448 | 933 | 79622993 |
Injection site bruising | 19.34 | 10.35 | 20 | 120442 | 40982 | 79582944 |
Respiratory arrest | 19.32 | 10.35 | 151 | 120311 | 57399 | 79566527 |
Anaemia megaloblastic | 19.28 | 10.35 | 12 | 120450 | 623 | 79623303 |
Adverse drug reaction | 19.24 | 10.35 | 45 | 120417 | 66347 | 79557579 |
Confusional state | 19.17 | 10.35 | 622 | 119840 | 317375 | 79306551 |
Red blood cell sedimentation rate increased | 18.88 | 10.35 | 25 | 120437 | 45917 | 79578009 |
Affective disorder | 18.88 | 10.35 | 40 | 120422 | 8279 | 79615647 |
COVID-19 pneumonia | 18.86 | 10.35 | 10 | 120452 | 28839 | 79595087 |
Urinary incontinence | 18.86 | 10.35 | 116 | 120346 | 40793 | 79583133 |
Gastroenteritis viral | 18.76 | 10.35 | 7 | 120455 | 24824 | 79599102 |
Candida infection | 18.76 | 10.35 | 18 | 120444 | 38196 | 79585730 |
Perseveration | 18.74 | 10.35 | 10 | 120452 | 387 | 79623539 |
Blood hyposmosis | 18.73 | 10.35 | 5 | 120457 | 24 | 79623902 |
Fabry's disease | 18.73 | 10.35 | 5 | 120457 | 24 | 79623902 |
Incoherent | 18.65 | 10.35 | 38 | 120424 | 7654 | 79616272 |
Measles | 18.65 | 10.35 | 10 | 120452 | 391 | 79623535 |
Atrioventricular block | 18.62 | 10.35 | 55 | 120407 | 13986 | 79609940 |
Hyperdynamic left ventricle | 18.60 | 10.35 | 10 | 120452 | 393 | 79623533 |
Cardiac arrest | 18.53 | 10.35 | 364 | 120098 | 171732 | 79452194 |
Fanconi syndrome | 18.16 | 10.35 | 22 | 120440 | 2834 | 79621092 |
Dermatitis bullous | 18.14 | 10.35 | 55 | 120407 | 14190 | 79609736 |
Abortion threatened | 18.10 | 10.35 | 10 | 120452 | 415 | 79623511 |
Polydipsia psychogenic | 17.99 | 10.35 | 8 | 120454 | 206 | 79623720 |
Transfusion | 17.91 | 10.35 | 5 | 120457 | 21325 | 79602601 |
Hyperthermia | 17.91 | 10.35 | 64 | 120398 | 17973 | 79605953 |
Diabetic neuropathy | 17.87 | 10.35 | 33 | 120429 | 6183 | 79617743 |
Emotional disorder | 17.81 | 10.35 | 55 | 120407 | 14332 | 79609594 |
Right ventricular dilatation | 17.71 | 10.35 | 18 | 120444 | 1908 | 79622018 |
Fulminant type 1 diabetes mellitus | 17.70 | 10.35 | 16 | 120446 | 1467 | 79622459 |
Logorrhoea | 17.66 | 10.35 | 27 | 120435 | 4338 | 79619588 |
Hyperprolactinaemia | 17.63 | 10.35 | 28 | 120434 | 4648 | 79619278 |
Therapy interrupted | 17.55 | 10.35 | 13 | 120449 | 31328 | 79592598 |
Pneumocystis jirovecii pneumonia | 17.54 | 10.35 | 14 | 120448 | 32494 | 79591432 |
Genital ulceration | 17.50 | 10.35 | 14 | 120448 | 1086 | 79622840 |
Unevaluable event | 17.49 | 10.35 | 36 | 120426 | 55549 | 79568377 |
Rickets | 17.48 | 10.35 | 6 | 120456 | 75 | 79623851 |
Eosinophilic oesophagitis | 17.47 | 10.35 | 11 | 120451 | 583 | 79623343 |
Unresponsive to stimuli | 17.44 | 10.35 | 144 | 120318 | 55644 | 79568282 |
Bipolar disorder | 17.43 | 10.35 | 37 | 120425 | 7670 | 79616256 |
Transplant rejection | 17.39 | 10.35 | 4 | 120458 | 19433 | 79604493 |
Epidermal necrosis | 17.39 | 10.35 | 16 | 120446 | 1501 | 79622425 |
Thrombocytopenic purpura | 17.32 | 10.35 | 20 | 120442 | 2449 | 79621477 |
Derailment | 17.26 | 10.35 | 6 | 120456 | 78 | 79623848 |
Herpes zoster | 17.26 | 10.35 | 77 | 120385 | 93006 | 79530920 |
Benzodiazepine drug level increased | 17.24 | 10.35 | 8 | 120454 | 228 | 79623698 |
Lactate pyruvate ratio increased | 17.20 | 10.35 | 6 | 120456 | 79 | 79623847 |
Labelled drug-drug interaction medication error | 17.17 | 10.35 | 85 | 120377 | 27565 | 79596361 |
Mitral valve incompetence | 17.12 | 10.35 | 11 | 120451 | 28554 | 79595372 |
Oedema | 17.11 | 10.35 | 108 | 120354 | 119472 | 79504454 |
Wrong technique in product usage process | 17.00 | 10.35 | 56 | 120406 | 73819 | 79550107 |
Inappropriate schedule of product administration | 16.98 | 10.35 | 125 | 120337 | 133503 | 79490423 |
Conjunctival oedema | 16.87 | 10.35 | 14 | 120448 | 1144 | 79622782 |
Muscle rigidity | 16.80 | 10.35 | 67 | 120395 | 19815 | 79604111 |
Feeling of despair | 16.76 | 10.35 | 21 | 120441 | 2800 | 79621126 |
Paresis | 16.74 | 10.35 | 26 | 120436 | 4235 | 79619691 |
Extensor plantar response | 16.71 | 10.35 | 17 | 120445 | 1804 | 79622122 |
Areflexia | 16.70 | 10.35 | 30 | 120432 | 5504 | 79618422 |
Chills | 16.68 | 10.35 | 158 | 120304 | 160076 | 79463850 |
Cytomegalovirus mucocutaneous ulcer | 16.67 | 10.35 | 6 | 120456 | 87 | 79623839 |
Bacteraemia | 16.66 | 10.35 | 15 | 120447 | 32809 | 79591117 |
Pleural neoplasm | 16.62 | 10.35 | 9 | 120453 | 359 | 79623567 |
Suspiciousness | 16.61 | 10.35 | 11 | 120451 | 636 | 79623290 |
Scab | 16.57 | 10.35 | 44 | 120418 | 10528 | 79613398 |
Nodule | 16.53 | 10.35 | 7 | 120455 | 22987 | 79600939 |
Drug level above therapeutic | 16.50 | 10.35 | 39 | 120423 | 8684 | 79615242 |
SUNCT syndrome | 16.49 | 10.35 | 3 | 120459 | 0 | 79623926 |
Tensilon test abnormal | 16.49 | 10.35 | 3 | 120459 | 0 | 79623926 |
Urticaria vesiculosa | 16.46 | 10.35 | 4 | 120458 | 12 | 79623914 |
Malaise | 16.44 | 10.35 | 590 | 119872 | 489279 | 79134647 |
Hepatitis | 16.44 | 10.35 | 142 | 120320 | 55585 | 79568341 |
Bradycardia | 16.42 | 10.35 | 292 | 120170 | 135265 | 79488661 |
Carcinoembryonic antigen | 16.36 | 10.35 | 6 | 120456 | 92 | 79623834 |
Nephrolithiasis | 16.36 | 10.35 | 35 | 120427 | 53256 | 79570670 |
Petechiae | 16.34 | 10.35 | 68 | 120394 | 20497 | 79603429 |
Foot deformity | 16.26 | 10.35 | 8 | 120454 | 24066 | 79599860 |
Vaginal erosion | 16.22 | 10.35 | 4 | 120458 | 13 | 79623913 |
Carbohydrate antigen 15-3 | 16.18 | 10.35 | 6 | 120456 | 95 | 79623831 |
Pulmonary fibrosis | 16.17 | 10.35 | 26 | 120436 | 44086 | 79579840 |
Drowning | 16.17 | 10.35 | 12 | 120450 | 833 | 79623093 |
Encephalocele | 16.14 | 10.35 | 5 | 120457 | 44 | 79623882 |
Tumour lysis syndrome | 16.10 | 10.35 | 8 | 120454 | 23931 | 79599995 |
Clostridium difficile colitis | 16.09 | 10.35 | 15 | 120447 | 32268 | 79591658 |
Hot flush | 16.06 | 10.35 | 37 | 120425 | 54840 | 79569086 |
Vaginal ulceration | 15.97 | 10.35 | 8 | 120454 | 271 | 79623655 |
Low set ears | 15.90 | 10.35 | 6 | 120456 | 100 | 79623826 |
Hallucination, visual | 15.85 | 10.35 | 94 | 120368 | 32635 | 79591291 |
Tic | 15.81 | 10.35 | 21 | 120441 | 2965 | 79620961 |
Subacute cutaneous lupus erythematosus | 15.80 | 10.35 | 23 | 120439 | 3538 | 79620388 |
Right ventricular failure | 15.58 | 10.35 | 8 | 120454 | 23489 | 79600437 |
Ultrasound liver abnormal | 15.58 | 10.35 | 7 | 120455 | 185 | 79623741 |
Cholestasis | 15.49 | 10.35 | 133 | 120329 | 51976 | 79571950 |
Drug dependence | 15.40 | 10.35 | 110 | 120352 | 40659 | 79583267 |
Sensory disturbance | 15.40 | 10.35 | 54 | 120408 | 15023 | 79608903 |
Upper respiratory tract infection | 15.39 | 10.35 | 78 | 120384 | 91090 | 79532836 |
Therapeutic product effective for unapproved indication | 15.38 | 10.35 | 6 | 120456 | 110 | 79623816 |
Vitamin D deficiency | 15.33 | 10.35 | 52 | 120410 | 14227 | 79609699 |
Dry skin | 15.33 | 10.35 | 52 | 120410 | 67943 | 79555983 |
Cranial nerve disorder | 15.30 | 10.35 | 13 | 120449 | 1097 | 79622829 |
Polydipsia | 15.27 | 10.35 | 32 | 120430 | 6573 | 79617353 |
Oral mucosal eruption | 15.26 | 10.35 | 11 | 120451 | 730 | 79623196 |
Colitis ulcerative | 15.23 | 10.35 | 18 | 120444 | 34724 | 79589202 |
Distractibility | 15.20 | 10.35 | 11 | 120451 | 734 | 79623192 |
Neurosis | 15.17 | 10.35 | 9 | 120453 | 428 | 79623498 |
Encephalopathy | 15.07 | 10.35 | 162 | 120300 | 67235 | 79556691 |
Weight increased | 15.05 | 10.35 | 312 | 120150 | 277074 | 79346852 |
SJS-TEN overlap | 15.02 | 10.35 | 11 | 120451 | 748 | 79623178 |
Learning disability | 14.98 | 10.35 | 7 | 120455 | 203 | 79623723 |
Lip ulceration | 14.93 | 10.35 | 18 | 120444 | 2307 | 79621619 |
Idiopathic generalised epilepsy | 14.90 | 10.35 | 5 | 120457 | 58 | 79623868 |
Hypothermia | 14.90 | 10.35 | 71 | 120391 | 22675 | 79601251 |
Ulcer | 14.85 | 10.35 | 14 | 120448 | 29958 | 79593968 |
Cytomegalovirus infection | 14.83 | 10.35 | 26 | 120436 | 42618 | 79581308 |
Blood citric acid increased | 14.83 | 10.35 | 5 | 120457 | 59 | 79623867 |
Peripheral venous disease | 14.79 | 10.35 | 3 | 120459 | 15906 | 79608020 |
Sciatica | 14.79 | 10.35 | 17 | 120445 | 33205 | 79590721 |
Depressive symptom | 14.71 | 10.35 | 31 | 120431 | 6392 | 79617534 |
Frontotemporal dementia | 14.69 | 10.35 | 10 | 120452 | 605 | 79623321 |
Hangover | 14.63 | 10.35 | 17 | 120445 | 2095 | 79621831 |
Disorganised speech | 14.60 | 10.35 | 17 | 120445 | 2100 | 79621826 |
Negative thoughts | 14.59 | 10.35 | 14 | 120448 | 1385 | 79622541 |
Hypomania | 14.56 | 10.35 | 34 | 120428 | 7510 | 79616416 |
Visual field defect | 14.54 | 10.35 | 38 | 120424 | 9007 | 79614919 |
Pericardial effusion | 14.50 | 10.35 | 30 | 120432 | 46207 | 79577719 |
Acute respiratory failure | 14.49 | 10.35 | 44 | 120418 | 59497 | 79564429 |
Paranoia | 14.47 | 10.35 | 63 | 120399 | 19369 | 79604557 |
Human herpesvirus 7 infection | 14.45 | 10.35 | 6 | 120456 | 130 | 79623796 |
Macule | 14.45 | 10.35 | 20 | 120442 | 2937 | 79620989 |
Hypoglycaemia | 14.41 | 10.35 | 92 | 120370 | 101502 | 79522424 |
Sinus disorder | 14.38 | 10.35 | 8 | 120454 | 22456 | 79601470 |
Priapism | 14.34 | 10.35 | 25 | 120437 | 4480 | 79619446 |
Angina pectoris | 14.25 | 10.35 | 36 | 120426 | 51696 | 79572230 |
Neoplasm progression | 14.21 | 10.35 | 36 | 120426 | 51646 | 79572280 |
Skin lesion | 14.16 | 10.35 | 110 | 120352 | 41734 | 79582192 |
Developmental delay | 14.14 | 10.35 | 13 | 120449 | 1218 | 79622708 |
Migraine | 14.13 | 10.35 | 76 | 120386 | 87417 | 79536509 |
Epileptic encephalopathy | 14.12 | 10.35 | 9 | 120453 | 487 | 79623439 |
Melaena | 14.11 | 10.35 | 46 | 120416 | 60844 | 79563082 |
Wrong dose | 14.09 | 10.35 | 15 | 120447 | 1679 | 79622247 |
Antipsychotic drug level below therapeutic | 14.08 | 10.35 | 13 | 120449 | 1225 | 79622701 |
Screaming | 14.08 | 10.35 | 23 | 120439 | 3910 | 79620016 |
Liver function test increased | 14.06 | 10.35 | 24 | 120438 | 39749 | 79584177 |
Loss of personal independence in daily activities | 13.99 | 10.35 | 94 | 120368 | 102486 | 79521440 |
Tooth development disorder | 13.99 | 10.35 | 5 | 120457 | 71 | 79623855 |
Joint injury | 13.98 | 10.35 | 16 | 120446 | 31319 | 79592607 |
Bundle branch block right | 13.91 | 10.35 | 43 | 120419 | 11208 | 79612718 |
Red cell distribution width increased | 13.91 | 10.35 | 3 | 120459 | 15239 | 79608687 |
Therapy cessation | 13.90 | 10.35 | 22 | 120440 | 37540 | 79586386 |
Vision blurred | 13.87 | 10.35 | 231 | 120231 | 105667 | 79518259 |
Respiratory depression | 13.79 | 10.35 | 80 | 120382 | 27550 | 79596376 |
Gastric disorder | 13.78 | 10.35 | 22 | 120440 | 37411 | 79586515 |
Rash pustular | 13.78 | 10.35 | 43 | 120419 | 11268 | 79612658 |
Bone metabolism disorder | 13.77 | 10.35 | 9 | 120453 | 509 | 79623417 |
Guillain-Barre syndrome | 13.73 | 10.35 | 37 | 120425 | 8928 | 79614998 |
Congenital arterial malformation | 13.71 | 10.35 | 4 | 120458 | 28 | 79623898 |
Blood immunoglobulin G decreased | 13.67 | 10.35 | 21 | 120441 | 3388 | 79620538 |
Pyroglutamate increased | 13.54 | 10.35 | 10 | 120452 | 689 | 79623237 |
Gastrooesophageal reflux disease | 13.49 | 10.35 | 97 | 120365 | 104149 | 79519777 |
Diverticulum | 13.46 | 10.35 | 3 | 120459 | 14893 | 79609033 |
Rhinitis allergic | 13.46 | 10.35 | 45 | 120417 | 12224 | 79611702 |
Juvenile myoclonic epilepsy | 13.44 | 10.35 | 5 | 120457 | 80 | 79623846 |
Hypoxia | 13.39 | 10.35 | 96 | 120366 | 103147 | 79520779 |
Blood test abnormal | 13.37 | 10.35 | 5 | 120457 | 17705 | 79606221 |
Treatment noncompliance | 13.30 | 10.35 | 129 | 120333 | 52139 | 79571787 |
Blood creatinine increased | 13.27 | 10.35 | 160 | 120302 | 154897 | 79469029 |
Antisocial behaviour | 13.26 | 10.35 | 10 | 120452 | 711 | 79623215 |
Inhibitory drug interaction | 13.26 | 10.35 | 24 | 120438 | 4429 | 79619497 |
Paralogism | 13.25 | 10.35 | 4 | 120458 | 32 | 79623894 |
Drug half-life reduced | 13.20 | 10.35 | 3 | 120459 | 6 | 79623920 |
Apgar score low | 13.20 | 10.35 | 3 | 120459 | 6 | 79623920 |
Thrombotic microangiopathy | 13.17 | 10.35 | 7 | 120455 | 20162 | 79603764 |
Pyuria | 13.17 | 10.35 | 17 | 120445 | 2335 | 79621591 |
Flatulence | 13.16 | 10.35 | 28 | 120434 | 42696 | 79581230 |
Lower gastrointestinal haemorrhage | 13.13 | 10.35 | 4 | 120458 | 16121 | 79607805 |
Xanthelasma | 13.13 | 10.35 | 6 | 120456 | 165 | 79623761 |
Sluggishness | 13.11 | 10.35 | 30 | 120432 | 6542 | 79617384 |
Obsessive thoughts | 13.09 | 10.35 | 12 | 120450 | 1120 | 79622806 |
Staring | 13.09 | 10.35 | 18 | 120444 | 2627 | 79621299 |
Pancytopenia | 13.08 | 10.35 | 174 | 120288 | 165571 | 79458355 |
Infrapatellar fat pad inflammation | 13.06 | 10.35 | 6 | 120456 | 167 | 79623759 |
Coagulation time shortened | 13.05 | 10.35 | 8 | 120454 | 404 | 79623522 |
Device issue | 13.04 | 10.35 | 13 | 120449 | 27095 | 79596831 |
Rheumatoid nodule | 13.04 | 10.35 | 5 | 120457 | 17433 | 79606493 |
Medulloblastoma | 13.00 | 10.35 | 5 | 120457 | 88 | 79623838 |
Localised infection | 12.99 | 10.35 | 23 | 120439 | 37552 | 79586374 |
Drug level changed | 12.91 | 10.35 | 9 | 120453 | 566 | 79623360 |
Agranulocytosis | 12.90 | 10.35 | 114 | 120348 | 44916 | 79579010 |
Caesarean section | 12.89 | 10.35 | 45 | 120417 | 12490 | 79611436 |
Bipolar I disorder | 12.89 | 10.35 | 16 | 120446 | 2113 | 79621813 |
Sinus congestion | 12.86 | 10.35 | 7 | 120455 | 19889 | 79604037 |
Diabetes insipidus | 12.85 | 10.35 | 26 | 120436 | 5211 | 79618715 |
Therapeutic response shortened | 12.80 | 10.35 | 4 | 120458 | 15859 | 79608067 |
Intentional product misuse to child | 12.80 | 10.35 | 5 | 120457 | 92 | 79623834 |
Device related infection | 12.77 | 10.35 | 20 | 120442 | 34274 | 79589652 |
Thyroid adenoma | 12.77 | 10.35 | 6 | 120456 | 176 | 79623750 |
Second primary malignancy | 12.75 | 10.35 | 3 | 120459 | 14347 | 79609579 |
Pigmentation disorder | 12.74 | 10.35 | 27 | 120435 | 5591 | 79618335 |
Illiteracy | 12.73 | 10.35 | 4 | 120458 | 37 | 79623889 |
Dry age-related macular degeneration | 12.73 | 10.35 | 7 | 120455 | 288 | 79623638 |
Intervertebral disc degeneration | 12.71 | 10.35 | 4 | 120458 | 15781 | 79608145 |
Wrong drug | 12.70 | 10.35 | 7 | 120455 | 289 | 79623637 |
Disability | 12.65 | 10.35 | 5 | 120457 | 17115 | 79606811 |
Abortion | 12.65 | 10.35 | 13 | 120449 | 1397 | 79622529 |
Wrong product administered | 12.62 | 10.35 | 36 | 120426 | 8976 | 79614950 |
Granulocytopenia | 12.60 | 10.35 | 42 | 120420 | 11389 | 79612537 |
Muscle twitching | 12.56 | 10.35 | 72 | 120390 | 24692 | 79599234 |
Eye discharge | 12.54 | 10.35 | 28 | 120434 | 6006 | 79617920 |
Glycosuria | 12.54 | 10.35 | 16 | 120446 | 2172 | 79621754 |
Pupillary reflex impaired | 12.53 | 10.35 | 20 | 120442 | 3333 | 79620593 |
Lower limb fracture | 12.52 | 10.35 | 10 | 120452 | 23205 | 79600721 |
Cardiomyopathy | 12.51 | 10.35 | 15 | 120447 | 28759 | 79595167 |
Squamous cell carcinoma | 12.50 | 10.35 | 4 | 120458 | 15618 | 79608308 |
Automatism | 12.50 | 10.35 | 6 | 120456 | 185 | 79623741 |
Throat irritation | 12.48 | 10.35 | 27 | 120435 | 40919 | 79583007 |
Appendicitis | 12.47 | 10.35 | 8 | 120454 | 20786 | 79603140 |
Gastric hypomotility | 12.47 | 10.35 | 6 | 120456 | 186 | 79623740 |
Niemann-Pick disease | 12.46 | 10.35 | 4 | 120458 | 40 | 79623886 |
Open angle glaucoma | 12.45 | 10.35 | 8 | 120454 | 439 | 79623487 |
Hypersexuality | 12.45 | 10.35 | 14 | 120448 | 1666 | 79622260 |
Neurotoxicity | 12.44 | 10.35 | 88 | 120374 | 32430 | 79591496 |
Maternal drugs affecting foetus | 12.43 | 10.35 | 14 | 120448 | 1669 | 79622257 |
Pseudophaeochromocytoma | 12.37 | 10.35 | 5 | 120457 | 101 | 79623825 |
Crying | 12.35 | 10.35 | 68 | 120394 | 22975 | 79600951 |
Grip strength decreased | 12.34 | 10.35 | 9 | 120453 | 21860 | 79602066 |
Drug ineffective | 12.32 | 10.35 | 1836 | 118626 | 1079077 | 78544849 |
Bone marrow failure | 12.27 | 10.35 | 38 | 120424 | 51069 | 79572857 |
Hypochloraemia | 12.27 | 10.35 | 17 | 120445 | 2498 | 79621428 |
Product dispensing error | 12.27 | 10.35 | 46 | 120416 | 13217 | 79610709 |
Biopsy skin abnormal | 12.26 | 10.35 | 6 | 120456 | 193 | 79623733 |
Low birth weight baby | 12.26 | 10.35 | 9 | 120453 | 614 | 79623312 |
Impaired driving ability | 12.25 | 10.35 | 26 | 120436 | 5389 | 79618537 |
Onychophagia | 12.19 | 10.35 | 5 | 120457 | 105 | 79623821 |
Injury | 12.14 | 10.35 | 68 | 120394 | 77428 | 79546498 |
Tonic clonic movements | 12.11 | 10.35 | 16 | 120446 | 2248 | 79621678 |
Hyperglycinaemia | 12.11 | 10.35 | 3 | 120459 | 10 | 79623916 |
Selective IgA immunodeficiency | 12.11 | 10.35 | 3 | 120459 | 10 | 79623916 |
Injection site rash | 12.07 | 10.35 | 6 | 120456 | 17948 | 79605978 |
Blood pressure diastolic abnormal | 12.06 | 10.35 | 7 | 120455 | 19195 | 79604731 |
Iliac artery occlusion | 12.05 | 10.35 | 7 | 120455 | 320 | 79623606 |
Nephropathy toxic | 12.05 | 10.35 | 8 | 120454 | 20411 | 79603515 |
Skin oedema | 12.04 | 10.35 | 14 | 120448 | 1727 | 79622199 |
Genital burning sensation | 12.03 | 10.35 | 7 | 120455 | 321 | 79623605 |
Glomerular filtration rate decreased | 11.97 | 10.35 | 10 | 120452 | 22692 | 79601234 |
Tuberculosis | 11.97 | 10.35 | 4 | 120458 | 15194 | 79608732 |
Tendonitis | 11.96 | 10.35 | 11 | 120451 | 23819 | 79600107 |
Heart rate decreased | 11.96 | 10.35 | 60 | 120402 | 70256 | 79553670 |
Feeling hot | 11.94 | 10.35 | 48 | 120414 | 59686 | 79564240 |
Odynophagia | 11.94 | 10.35 | 41 | 120421 | 11286 | 79612640 |
Neutropenic sepsis | 11.88 | 10.35 | 14 | 120448 | 27050 | 79596876 |
Device dislocation | 11.88 | 10.35 | 13 | 120449 | 25957 | 79597969 |
Renal phospholipidosis | 11.85 | 10.35 | 5 | 120457 | 113 | 79623813 |
Atelectasis | 11.84 | 10.35 | 19 | 120443 | 32238 | 79591688 |
Impulsive behaviour | 11.82 | 10.35 | 18 | 120444 | 2882 | 79621044 |
Encapsulating peritoneal sclerosis | 11.80 | 10.35 | 10 | 120452 | 841 | 79623085 |
Peritonitis | 11.79 | 10.35 | 15 | 120447 | 28021 | 79595905 |
Conjunctival disorder | 11.78 | 10.35 | 7 | 120455 | 334 | 79623592 |
Mucosal disorder | 11.78 | 10.35 | 20 | 120442 | 3508 | 79620418 |
Rhinorrhoea | 11.78 | 10.35 | 67 | 120395 | 76007 | 79547919 |
Parkinsonism | 11.77 | 10.35 | 53 | 120409 | 16531 | 79607395 |
Major depression | 11.74 | 10.35 | 35 | 120427 | 8945 | 79614981 |
Hepatomegaly | 11.70 | 10.35 | 58 | 120404 | 18816 | 79605110 |
Dissociative amnesia | 11.69 | 10.35 | 5 | 120457 | 117 | 79623809 |
Biopsy lymph gland abnormal | 11.68 | 10.35 | 3 | 120459 | 12 | 79623914 |
Hypoosmolar state | 11.67 | 10.35 | 7 | 120455 | 340 | 79623586 |
Near drowning | 11.65 | 10.35 | 4 | 120458 | 50 | 79623876 |
Acanthosis | 11.65 | 10.35 | 8 | 120454 | 491 | 79623435 |
Injection site haemorrhage | 11.62 | 10.35 | 15 | 120447 | 27855 | 79596071 |
Neuropsychiatric syndrome | 11.61 | 10.35 | 5 | 120457 | 119 | 79623807 |
Necrosis ischaemic | 11.54 | 10.35 | 11 | 120451 | 1079 | 79622847 |
Pulmonary embolism | 11.53 | 10.35 | 186 | 120276 | 171468 | 79452458 |
Speech disorder developmental | 11.51 | 10.35 | 9 | 120453 | 675 | 79623251 |
Cardio-respiratory arrest | 11.50 | 10.35 | 229 | 120233 | 108281 | 79515645 |
Ischaemic gastritis | 11.49 | 10.35 | 3 | 120459 | 13 | 79623913 |
Angiosclerosis | 11.49 | 10.35 | 3 | 120459 | 13 | 79623913 |
Disseminated intravascular coagulation | 11.46 | 10.35 | 93 | 120369 | 35749 | 79588177 |
Pneumatosis | 11.42 | 10.35 | 10 | 120452 | 879 | 79623047 |
Sensorimotor disorder | 11.37 | 10.35 | 10 | 120452 | 884 | 79623042 |
Type 2 diabetes mellitus | 11.36 | 10.35 | 46 | 120416 | 57076 | 79566850 |
Carnitine decreased | 11.31 | 10.35 | 3 | 120459 | 14 | 79623912 |
Conjunctival discolouration | 11.27 | 10.35 | 5 | 120457 | 128 | 79623798 |
Tricuspid valve incompetence | 11.27 | 10.35 | 8 | 120454 | 19704 | 79604222 |
Colectomy total | 11.24 | 10.35 | 7 | 120455 | 364 | 79623562 |
Acid base balance abnormal | 11.22 | 10.35 | 7 | 120455 | 365 | 79623561 |
Tetany | 11.21 | 10.35 | 17 | 120445 | 2711 | 79621215 |
Ileus paralytic | 11.19 | 10.35 | 36 | 120426 | 9584 | 79614342 |
Patient uncooperative | 11.17 | 10.35 | 9 | 120453 | 705 | 79623221 |
Hepatitis fulminant | 11.15 | 10.35 | 30 | 120432 | 7232 | 79616694 |
Enlarged cerebral perivascular spaces | 11.14 | 10.35 | 3 | 120459 | 15 | 79623911 |
Myelosuppression | 11.13 | 10.35 | 28 | 120434 | 40268 | 79583658 |
Vestibular disorder | 11.10 | 10.35 | 16 | 120446 | 2439 | 79621487 |
Nervous system disorder | 11.05 | 10.35 | 74 | 120388 | 26782 | 79597144 |
Oral disorder | 11.05 | 10.35 | 37 | 120425 | 10058 | 79613868 |
Deep vein thrombosis | 11.04 | 10.35 | 123 | 120339 | 120796 | 79503130 |
Hypoproteinaemia | 11.03 | 10.35 | 21 | 120441 | 4025 | 79619901 |
Febrile bone marrow aplasia | 11.03 | 10.35 | 3 | 120459 | 13017 | 79610909 |
Respiratory disorder | 11.02 | 10.35 | 33 | 120429 | 44823 | 79579103 |
Histiocytic necrotising lymphadenitis | 10.99 | 10.35 | 4 | 120458 | 60 | 79623866 |
Congenital anomaly | 10.98 | 10.35 | 7 | 120455 | 379 | 79623547 |
Wound infection | 10.98 | 10.35 | 12 | 120450 | 23979 | 79599947 |
Myelodysplastic syndrome | 10.98 | 10.35 | 18 | 120444 | 30283 | 79593643 |
Anaplastic large cell lymphoma T- and null-cell types | 10.93 | 10.35 | 5 | 120457 | 138 | 79623788 |
Lip swelling | 10.92 | 10.35 | 102 | 120360 | 40809 | 79583117 |
Tardive dyskinesia | 10.92 | 10.35 | 38 | 120424 | 10533 | 79613393 |
Pathogen resistance | 10.91 | 10.35 | 4 | 120458 | 14338 | 79609588 |
Head injury | 10.91 | 10.35 | 95 | 120367 | 37274 | 79586652 |
Pulmonary toxicity | 10.89 | 10.35 | 3 | 120459 | 12911 | 79611015 |
Enterococcal infection | 10.89 | 10.35 | 5 | 120457 | 15655 | 79608271 |
Blood glucose increased | 10.87 | 10.35 | 116 | 120346 | 114859 | 79509067 |
Poor venous access | 10.86 | 10.35 | 7 | 120455 | 18142 | 79605784 |
Effusion | 10.86 | 10.35 | 15 | 120447 | 2199 | 79621727 |
Hyperacusis | 10.81 | 10.35 | 15 | 120447 | 2208 | 79621718 |
Cardiac murmur | 10.81 | 10.35 | 50 | 120412 | 15774 | 79608152 |
Sitting disability | 10.80 | 10.35 | 7 | 120455 | 390 | 79623536 |
Altered visual depth perception | 10.80 | 10.35 | 7 | 120455 | 390 | 79623536 |
Dementia | 10.79 | 10.35 | 69 | 120393 | 24590 | 79599336 |
Maculopathy | 10.77 | 10.35 | 17 | 120445 | 2808 | 79621118 |
Uveitis | 10.76 | 10.35 | 6 | 120456 | 16824 | 79607102 |
Lymphopenia | 10.72 | 10.35 | 81 | 120381 | 30476 | 79593450 |
Infusion site pain | 10.70 | 10.35 | 4 | 120458 | 14172 | 79609754 |
Basilar migraine | 10.69 | 10.35 | 4 | 120458 | 65 | 79623861 |
Growth hormone-producing pituitary tumour | 10.69 | 10.35 | 4 | 120458 | 65 | 79623861 |
Acinetobacter test positive | 10.69 | 10.35 | 6 | 120456 | 257 | 79623669 |
Breath odour | 10.68 | 10.35 | 13 | 120449 | 1683 | 79622243 |
Salivary gland calculus | 10.64 | 10.35 | 6 | 120456 | 259 | 79623667 |
Human herpesvirus 6 infection reactivation | 10.63 | 10.35 | 8 | 120454 | 567 | 79623359 |
Gastric ulcer | 10.63 | 10.35 | 22 | 120440 | 33883 | 79590043 |
Pain in jaw | 10.60 | 10.35 | 35 | 120427 | 46116 | 79577810 |
Mitochondrial cytopathy | 10.60 | 10.35 | 7 | 120455 | 403 | 79623523 |
Sperm concentration decreased | 10.58 | 10.35 | 4 | 120458 | 67 | 79623859 |
Anticonvulsant drug level abnormal | 10.58 | 10.35 | 4 | 120458 | 67 | 79623859 |
Trigemino-cardiac reflex | 10.56 | 10.35 | 6 | 120456 | 263 | 79623663 |
Erythema of eyelid | 10.54 | 10.35 | 16 | 120446 | 2554 | 79621372 |
Educational problem | 10.53 | 10.35 | 7 | 120455 | 407 | 79623519 |
Squamous cell carcinoma of skin | 10.53 | 10.35 | 4 | 120458 | 14029 | 79609897 |
Breast cancer | 10.52 | 10.35 | 22 | 120440 | 33759 | 79590167 |
Liver function test abnormal | 10.51 | 10.35 | 146 | 120316 | 64329 | 79559597 |
Respiratory tract infection | 10.46 | 10.35 | 38 | 120424 | 48651 | 79575275 |
Hyperbilirubinaemia | 10.43 | 10.35 | 13 | 120449 | 24505 | 79599421 |
Eyelid erosion | 10.42 | 10.35 | 4 | 120458 | 70 | 79623856 |
Lung disorder | 10.40 | 10.35 | 75 | 120387 | 80482 | 79543444 |
Stab wound | 10.40 | 10.35 | 6 | 120456 | 271 | 79623655 |
Mycoplasma infection | 10.39 | 10.35 | 9 | 120453 | 780 | 79623146 |
None
Source | Code | Description |
---|---|---|
ATC | N03AF01 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Carboxamide derivatives |
FDA PE | N0000008486 | Decreased Central Nervous System Disorganized Electrical Activity |
CHEBI has role | CHEBI:35477 | antimanic drugs |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:38633 | sodium channel blockers |
CHEBI has role | CHEBI:52290 | mitogens |
CHEBI has role | CHEBI:61115 | histone deacetylase inhibitors |
CHEBI has role | CHEBI:64370 | glutamate transporter activators |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D018692 | Antimanic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D065701 | Cytochrome P-450 CYP3A Inducers |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D026941 | Sodium Channel Blockers |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175751 | Mood Stabilizer |
FDA MoA | N0000185506 | Cytochrome P450 3A4 Inducers |
FDA MoA | N0000185507 | Cytochrome P450 2C9 Inducers |
FDA MoA | N0000185607 | Cytochrome P450 2C19 Inducers |
FDA MoA | N0000187064 | Cytochrome P450 2B6 Inducers |
FDA MoA | N0000191266 | Cytochrome P450 1A2 Inducers |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Mixed bipolar I disorder | indication | 16506000 | DOID:3312 |
Trigeminal neuralgia | indication | 31681005 | DOID:12098 |
Glossopharyngeal neuralgia | indication | 43763009 | DOID:14423 |
Tonic-clonic seizure | indication | 54200006 | |
Epilepsy | indication | 84757009 | DOID:1826 |
Bipolar disorder in remission | indication | 85248005 | |
Bipolar affective disorder, current episode manic | indication | 191618007 | |
Localization-related epilepsy | indication | 230381009 | DOID:2234 |
Lennox-Gastaut syndrome | indication | 230418006 | |
Tonic-clonic epilepsy | indication | 352818000 | DOID:7725 |
Epilepsy characterized by intractable complex partial seizures | indication | 442481002 | |
Simple partial seizure | indication | 117891000119100 | |
Mixed Epilepsy | indication | ||
Neurohypophyseal diabetes insipidus | off-label use | 45369008 | DOID:12388 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Neuropathic pain | off-label use | 247398009 | |
Attention deficit hyperactivity disorder | off-label use | 406506008 | |
Prevention of Seizures following Cranial Trauma or Surgery | off-label use | ||
Rapid Cycling Bipolar Affective Disorder | off-label use | ||
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Suicidal thoughts | contraindication | 6471006 | |
Hypercholesterolemia | contraindication | 13644009 | |
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Mood swings | contraindication | 18963009 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Complete atrioventricular block | contraindication | 27885002 | |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Absence seizure | contraindication | 79631006 | |
Hyponatremia | contraindication | 89627008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Pancytopenia | contraindication | 127034005 | DOID:12450 |
Impaired renal function disorder | contraindication | 197663003 | |
Non-infective meningitis | contraindication | 230155003 | |
Acute intermittent porphyria | contraindication | 234422006 | DOID:3890 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Aplastic anemia | contraindication | 306058006 | DOID:12449 |
Bone marrow depression | contraindication | 307762000 | |
Disorder of coronary artery | contraindication | 414024009 | |
HLA-B 1502 Positive Status | contraindication | ||
Carbamazepine Toxicity | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.13 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
100MG | EQUETRO | VALIDUS PHARMS | N021710 | Dec. 10, 2004 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 6977253 | May 19, 2024 | THE RECOMMENDED INITIAL DOSE OF EQUETRO IS 400MG/DAY GIVEN IN DIVIDED DOSES, TWICE DAILY. THE DOSE SHOULD BE ADJUSTED IN 200MG DAILY INCREMENTS TO ACHIEVE OPTIMAL CLINICAL RESPONSE. |
200MG | EQUETRO | VALIDUS PHARMS | N021710 | Dec. 10, 2004 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 6977253 | May 19, 2024 | THE RECOMMENDED INITIAL DOSE OF EQUETRO IS 400MG/DAY GIVEN IN DIVIDED DOSES, TWICE DAILY. THE DOSE SHOULD BE ADJUSTED IN 200MG DAILY INCREMENTS TO ACHIEVE OPTIMAL CLINICAL RESPONSE. |
300MG | EQUETRO | VALIDUS PHARMS | N021710 | Dec. 10, 2004 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 6977253 | May 19, 2024 | THE RECOMMENDED INITIAL DOSE OF EQUETRO IS 400MG/DAY GIVEN IN DIVIDED DOSES, TWICE DAILY. THE DOSE SHOULD BE ADJUSTED IN 200MG DAILY INCREMENTS TO ACHIEVE OPTIMAL CLINICAL RESPONSE. |
200MG/20ML (10MG/ML) | CARNEXIV | LUNDBECK PHARMS LLC | N206030 | Oct. 7, 2016 | DISCN | SOLUTION | INTRAVENOUS | 9629797 | Nov. 10, 2028 | REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE IN ADULTS WITH GENERALIZED TONIC-CLONIC SEIZURES |
200MG/20ML (10MG/ML) | CARNEXIV | LUNDBECK PHARMS LLC | N206030 | Oct. 7, 2016 | DISCN | SOLUTION | INTRAVENOUS | 9629797 | Nov. 10, 2028 | REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE IN ADULTS WITH MIXED SEIZURE PATTERNS THAT INCLUDE PARTIAL SEIZURES WITH COMPLEX SYMPTOMATOLOGY, GENERALIZED TONIC-CLONIC SEIZURES, OR OTHER PARTIAL OR GENERALIZED SEIZURES |
200MG/20ML (10MG/ML) | CARNEXIV | LUNDBECK PHARMS LLC | N206030 | Oct. 7, 2016 | DISCN | SOLUTION | INTRAVENOUS | 9629797 | Nov. 10, 2028 | REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE IN ADULTS WITH PARTIAL SEIZURES WITH COMPLEX SYMPTOMATOLOGY |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
200MG/20ML (10MG/ML) | CARNEXIV | LUNDBECK PHARMS LLC | N206030 | Oct. 7, 2016 | DISCN | SOLUTION | INTRAVENOUS | Oct. 7, 2023 | REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE FORMULATIONS, WHEN ORAL ADMINISTRATION IS TEMPORARILY NOT FEASIBLE, IN ADULTS WITH THE FOLLOWING SEIZURE TYPES: PARTIAL WITH COMPLEX SYMPTOMOLOGY, GENERALIZED CLONIC-TONIC, AND MIXED |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 4 subunit alpha | Ion channel | BLOCKER | Ki | 4.28 | CHEMBL | CHEMBL | |||
Sodium channel protein type 9 subunit alpha | Ion channel | BLOCKER | IC50 | 4.66 | CHEMBL | CHEMBL | |||
Sodium channel protein type 5 subunit alpha | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | WOMBAT-PK | |||||||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | WOMBAT-PK | |||||||
Neuronal acetylcholine receptor; alpha2/beta4 | Ion channel | IC50 | 4.31 | WOMBAT-PK | |||||
Frizzled-8 | GPCR | ALLOSTERIC MODULATOR | Kd | 4.77 | IUPHAR | ||||
Sodium-dependent serotonin transporter | Transporter | Kd | 4.50 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 4.13 | WOMBAT-PK | |||||
Frizzled-8 | GPCR | Kd | 4.78 | CHEMBL |
ID | Source |
---|---|
4017873 | VUID |
N0000146226 | NUI |
D00252 | KEGG_DRUG |
2002 | RXNORM |
C0006949 | UMLSCUI |
CHEBI:3387 | CHEBI |
N6W | PDB_CHEM_ID |
CHEMBL108 | ChEMBL_ID |
DB00564 | DRUGBANK_ID |
D002220 | MESH_DESCRIPTOR_UI |
2554 | PUBCHEM_CID |
5339 | IUPHAR_LIGAND_ID |
1836 | INN_ID |
85756-57-6 | SECONDARY_CAS_RN |
33CM23913M | UNII |
4350 | MMSL |
513 | MMSL |
d00058 | MMSL |
387222003 | SNOMEDCT_US |
40820003 | SNOMEDCT_US |
4017873 | VANDF |
001634 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Tegretol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0508 | SUSPENSION | 100 mg | ORAL | NDA | 27 sections |
Tegretol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0508 | SUSPENSION | 100 mg | ORAL | NDA | 27 sections |
Tegretol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0508 | SUSPENSION | 100 mg | ORAL | NDA | 27 sections |
Tegretol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0509 | TABLET | 200 mg | ORAL | NDA | 27 sections |
Tegretol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0509 | TABLET | 200 mg | ORAL | NDA | 27 sections |
Tegretol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0509 | TABLET | 200 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0510 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0510 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0510 | TABLET, EXTENDED RELEASE | 100 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0511 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0511 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0511 | TABLET, EXTENDED RELEASE | 200 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0512 | TABLET, EXTENDED RELEASE | 400 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0512 | TABLET, EXTENDED RELEASE | 400 mg | ORAL | NDA | 27 sections |
TegretolXR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0512 | TABLET, EXTENDED RELEASE | 400 mg | ORAL | NDA | 27 sections |
Epitol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0090 | TABLET | 200 mg | ORAL | ANDA | 27 sections |
Epitol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0090 | TABLET | 200 mg | ORAL | ANDA | 27 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0109 | TABLET | 200 mg | ORAL | ANDA | 27 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0109 | TABLET | 200 mg | ORAL | ANDA | 27 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0778 | TABLET, CHEWABLE | 100 mg | ORAL | ANDA | 27 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0778 | TABLET, CHEWABLE | 100 mg | ORAL | ANDA | 27 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0862 | SUSPENSION | 100 mg | ORAL | ANDA | 28 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0947 | SUSPENSION | 100 mg | ORAL | ANDA | 29 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0947 | SUSPENSION | 100 mg | ORAL | ANDA | 29 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1724 | SUSPENSION | 200 mg | ORAL | ANDA | 28 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1894 | SUSPENSION | 200 mg | ORAL | ANDA | 29 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1894 | SUSPENSION | 200 mg | ORAL | ANDA | 29 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-3505 | TABLET | 200 mg | ORAL | ANDA | 21 sections |
CARBAMAZEPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-4515 | TABLET | 100 mg | ORAL | ANDA | 25 sections |
Carbamazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8125 | TABLET, CHEWABLE | 100 mg | ORAL | ANDA | 29 sections |