All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

dexrabeprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antiulcer, benzimidazole derivatives	4867	177795-60-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: E3810 dexrabeprazole dexrabeprazole sodium dexpure	Molecular weight: 359.44 Formula: C18H21N3O3S CLOGP: 2.08 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 77.10 ALOGS: -3.03 ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02BC07	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors
MeSH PA	D000897	Anti-Ulcer Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D054328	Proton Pump Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Erosive esophagitis	indication	40719004
Duodenal ulcer disease	indication	51868009	DOID:1724
Zollinger-Ellison syndrome	indication	53132006	DOID:0050782
Peptic reflux disease	indication	57643001
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Gastric ulcer	indication	397825006	DOID:10808
Gastric Hypersecretory Conditions	indication
Maintenance of Healing Erosive Esophagitis	indication
Duodenal Ulcer due to H. Pylori	indication
Pathological Gastric Hypersecretory Condition	indication
Upper gastrointestinal hemorrhage	off-label use	37372002
Chronic heart failure	contraindication	48447003
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Osteoporosis	contraindication	64859006	DOID:11476
Oliguria	contraindication	83128009
Atrophic gastritis	contraindication	84568007	DOID:8929
Fracture of bone	contraindication	125605004
Hypomagnesemia	contraindication	190855004
Disease of liver	contraindication	235856003	DOID:409
Edema	contraindication	267038008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.23	acidic
pKa2	3.9	Basic
pKa3	2.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Potassium-transporting ATPase	Transporter	P20648 P51164	ATP4A_HUMAN ATP4B_HUMAN	INHIBITOR				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.10		CHEMBL
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.74		CHEMBL
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN		IC50	5.07		CHEMBL
Platelet-derived growth factor receptor beta	Kinase	P09619	PGFRB_HUMAN		Kd	6.56		CHEMBL
Pyridoxal kinase	Kinase	O00764	PDXK_HUMAN		Kd	4.79		CHEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret	Kinase	P07949	RET_HUMAN		Kd	8.30		CHEMBL
Vascular endothelial growth factor receptor 1	Kinase	P17948	VGFR1_HUMAN		IC50	8.15		CHEMBL
Vascular endothelial growth factor receptor 2	Kinase	P35968	VGFR2_HUMAN		IC50	7.60		CHEMBL
Vascular endothelial growth factor receptor 3	Kinase	P35916	VGFR3_HUMAN		IC50	8		CHEMBL
Fibroblast growth factor receptor 3	Kinase	P22607	FGFR3_HUMAN		IC50	6.62		CHEMBL
Tyrosine-protein kinase Lyn	Kinase	P07948	LYN_HUMAN		Kd	5.56		CHEMBL
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.10		CHEMBL
Fatty acid synthase	Enzyme	P49327	FAS_HUMAN		Ki	5.23		CHEMBL
Fibroblast growth factor receptor 2	Kinase	P21802	FGFR2_HUMAN		IC50	7.08		CHEMBL
Receptor-interacting serine/threonine-protein kinase 2	Kinase	O43353	RIPK2_HUMAN		Kd	6.70		CHEMBL
Epithelial discoidin domain-containing receptor 1	Kinase	Q08345	DDR1_HUMAN		Kd	7.85		CHEMBL
Discoidin domain-containing receptor 2	Kinase	Q16832	DDR2_HUMAN		Kd	7.03		CHEMBL
Aurora kinase B	Kinase	Q96GD4	AURKB_HUMAN		Kd	4.64		CHEMBL
Insulin-degrading enzyme	Enzyme	P14735	IDE_HUMAN		IC50	4.96		CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Enzyme	O94760	DDAH1_HUMAN		IC50	4.28		CHEMBL
Cytosolic endo-beta-N-acetylglucosaminidase	Enzyme	Q8NFI3	ENASE_HUMAN		IC50	5.35		CHEMBL
Sterile alpha and TIR motif-containing protein 1	Unclassified	Q6SZW1	SARM1_HUMAN		IC50	5.50		CHEMBL
Fibroblast growth factor receptor 1	Kinase	P11362	FGFR1_HUMAN		IC50	7.76		CHEMBL

External reference:

ID	Source
65JK8810RM	UNII
171440-18-9	SECONDARY_CAS_RN
C3661450	UMLSCUI
CHEBI:134729	CHEBI
CHEMBL1615209	ChEMBL_ID
9906855	PUBCHEM_CID
DB13762	DRUGBANK_ID
CHEMBL2220486	ChEMBL_ID
CHEMBL1219	ChEMBL_ID
CHEMBL1200930	ChEMBL_ID
D064750	MESH_DESCRIPTOR_UI
C000595232	MESH_SUPPLEMENTAL_RECORD_UI
1177188006	SNOMEDCT_US
1179585005	SNOMEDCT_US
RZX	PDB_CHEM_ID

Pharmaceutical products:

None