corticorelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
pituitary hormone-release stimulating peptides 4858 86784-80-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • corticorelin
  • corticotropin-releasing factor (human)
  • corticorelin human
  • corticorelin acetate
  • Molecular weight: 4757.52
  • Formula: C208H344N60O63S2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 123
  • HDO: 67
  • TPSA: 1998.99
  • ALOGS:
  • ROTB: 163

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V04CD04 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for pituitary function

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diagnosis of Hypercortisolism indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.12 acidic
pKa2 3.55 acidic
pKa3 3.77 acidic
pKa4 3.97 acidic
pKa5 4.16 acidic
pKa6 4.38 acidic
pKa7 4.88 acidic
pKa8 12.2 acidic
pKa9 12.33 acidic
pKa10 12.56 acidic
pKa11 12.67 acidic
pKa12 12.8 acidic
pKa13 12.81 acidic
pKa14 13.01 acidic
pKa15 13.03 acidic
pKa16 13.2 acidic
pKa17 13.27 acidic
pKa18 13.28 acidic
pKa19 13.32 acidic
pKa20 13.47 acidic
pKa21 13.49 acidic
pKa22 13.55 acidic
pKa23 13.55 acidic
pKa24 13.65 acidic
pKa25 13.68 acidic
pKa26 13.79 acidic
pKa27 13.86 acidic
pKa28 13.87 acidic
pKa29 11.4 Basic
pKa30 10.93 Basic
pKa31 10.57 Basic
pKa32 10.16 Basic
pKa33 7.66 Basic
pKa34 6.99 Basic
pKa35 6.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Corticotropin-releasing factor receptor 1 GPCR AGONIST Kd 8.48 SCIENTIFIC LITERATURE IUPHAR
Corticotropin-releasing factor receptor 2 GPCR AGONIST Kd 7.40 IUPHAR
Corticotropin-releasing factor receptor 2 GPCR AGONIST Ki 7.80 IUPHAR
Corticotropin-releasing factor receptor 2 GPCR AGONIST Kd 7.90 IUPHAR

External reference:

IDSource
D03591 KEGG_DRUG
N0000007539 NUI
CHEBI:65312 CHEBI
CHEMBL2108182 ChEMBL_ID
6666 INN_ID
1312542-61-2 SECONDARY_CAS_RN
DB05394 DRUGBANK_ID
305OE8862Y UNII
16186200 PUBCHEM_CID
DB12915 DRUGBANK_ID
1927940 RXNORM
d04013 MMSL
006760 NDDF
007305 NDDF
71971001 SNOMEDCT_US
84986000 SNOMEDCT_US
C0010132 UMLSCUI
CHEMBL2107324 ChEMBL_ID

Pharmaceutical products:

None