sodium thiosalicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4856 134-23-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rexolate
  • thiosalicylic acid
  • sodium thiosalicylate
a degradation product of thimerosal; RN given refers to parent cpd
  • Molecular weight: 154.18
  • Formula: C7H6O2S
  • CLOGP: 2.44
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.96
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Rheumatic fever indication 58718002 DOID:1586
Osteoarthritis indication 396275006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.76 acidic
pKa2 6.38 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histone deacetylase 8 Enzyme EC50 4.77 CHEMBL

External reference:

IDSource
147-93-3 SECONDARY_CAS_RN
4019013 VANDF
CHEBI:9182 CHEBI
JKE PDB_CHEM_ID
C026196 MESH_SUPPLEMENTAL_RECORD_UI
C441201 MESH_SUPPLEMENTAL_RECORD_UI
C2D9ITW04B UNII
23690429 PUBCHEM_CID
DB14026 DRUGBANK_ID
219648 RXNORM
1165 MMSL
3661 MMSL
5498 MMSL
d00844 MMSL
001598 NDDF
25486007 SNOMEDCT_US
786423008 SNOMEDCT_US
C0304347 UMLSCUI
CHEMBL119888 ChEMBL_ID

Pharmaceutical products:

None