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| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4839 | 9087-70-1 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
|
| Dose | Unit | Route |
|---|---|---|
| 500 | TU | P |
None
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| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 29, 1993 | FDA | BAYER HLTHCARE |
None
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product use in unapproved indication | 246.01 | 212.31 | 69 | 134 | 184387 | 42436745 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product use in unapproved indication | 289.76 | 148.68 | 85 | 217 | 447292 | 110141705 |
| Off label use | 162.74 | 148.68 | 77 | 225 | 1500108 | 109088889 |
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| Source | Code | Description |
|---|---|---|
| ATC | B02AB01 | BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS ANTIFIBRINOLYTICS Proteinase inhibitors |
| MeSH PA | D003029 | Coagulants |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D006490 | Hemostatics |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D014361 | Trypsin Inhibitors |
| MeSH PA | D015842 | Serine Proteinase Inhibitors |
| FDA PE | N0000175632 | Decreased Fibrinolysis |
| FDA EPC | N0000175634 | Antifibrinolytic Agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hemorrhage | indication | 50960005 |
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None
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| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Plasminogen | Enzyme | INHIBITOR | IC50 | 6.80 | IUPHAR | CHEMBL | |||
| Plasma kallikrein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
| ID | Source |
|---|---|
| 04XPW8C0FL | UNII |
| 4020852 | VUID |
| N0000148360 | NUI |
| 4020852 | VANDF |
| C0003641 | UMLSCUI |
| CHEBI:749537 | CHEBI |
| CHEMBL1201619 | ChEMBL_ID |
| 16130295 | PUBCHEM_CID |
| DB06692 | DRUGBANK_ID |
| D007611 | MESH_DESCRIPTOR_UI |
| 2481 | INN_ID |
| 6570 | IUPHAR_LIGAND_ID |
| 1056 | RXNORM |
| 1439 | MMSL |
| 4215 | MMSL |
| d03185 | MMSL |
| 003455 | NDDF |
| 109008002 | SNOMEDCT_US |
| 386961008 | SNOMEDCT_US |
None