camostat Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
proteolytic enzyme inhibitors 471 59721-28-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • camostat monomethanesulfonate
  • camostat
  • camostat mesilate
  • camostat mesylate
  • Molecular weight: 398.42
  • Formula: C20H22N4O5
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 134.81
  • ALOGS: -3.80
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC B02AB04 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
ANTIFIBRINOLYTICS
Proteinase inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
MeSH PA D015842 Serine Proteinase Inhibitors
MeSH PA D014361 Trypsin Inhibitors
CHEBI has role CHEBI:22587 antiviral agents
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:48675 antifibrinolytic agents
CHEBI has role CHEBI:64926 serine proteinase inhibitors
CHEBI has role CHEBI:67079 antiinflammatory agents
CHEBI has role CHEBI:149553 anti-coronaviral agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Gastro-esophageal reflux disease with esophagitis indication 266433003

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Trypsin-1 Enzyme INHIBITOR IC50 7.30 CHEMBL IUPHAR
Solute carrier family 22 member 2 Transporter IC50 4.78 CHEMBL
Kallikrein-1 Enzyme IC50 5.83 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.90 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.54 CHEMBL
Prothrombin Enzyme IC50 4.50 CHEMBL
Hepatocyte growth factor activator Enzyme IC50 4.49 CHEMBL
Plasminogen Enzyme IC50 5.58 CHEMBL

External reference:

IDSource
D01766 KEGG_DRUG
59721-29-8 SECONDARY_CAS_RN
C0129975 UMLSCUI
CHEBI:135632 CHEBI
CHEMBL590799 ChEMBL_ID
DB13729 DRUGBANK_ID
5068 INN_ID
C034532 MESH_SUPPLEMENTAL_RECORD_UI
2536 PUBCHEM_CID
6432 IUPHAR_LIGAND_ID
0FD207WKDU UNII
018673 NDDF
018674 NDDF

Pharmaceutical products:

None