DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
camostat 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
proteolytic enzyme inhibitors
471
59721-28-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
camostat monomethanesulfonate
camostat
camostat mesilate
camostat mesylate
Molecular weight: 398.42
Formula: C20H22N4O5
CLOGP: 1.66
LIPINSKI: 0
HAC: 9
HDO: 3
TPSA: 134.81
ALOGS: -3.80
ROTB: 9
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
B02AB04
BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
ANTIFIBRINOLYTICS
Proteinase inhibitors
CHEBI has role
CHEBI:22587
antiviral agents
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:35674
antihypertensive drugs
CHEBI has role
CHEBI:48675
antifibrinolytic agent
CHEBI has role
CHEBI:64926
serine protease inhibitors
CHEBI has role
CHEBI:67079
anti-inflammatory agents
CHEBI has role
CHEBI:149553
anticoronaviral drug
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D011480
Protease Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Gastro-esophageal reflux disease with esophagitis
indication
266433003
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
10.66
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Trypsin-1
Enzyme
P07477
TRY1_HUMAN
INHIBITOR
IC50
7.30
CHEMBL
IUPHAR
Kallikrein-1
Enzyme
P06870
KLK1_HUMAN
IC50
5.83
CHEMBL
Solute carrier family 22 member 2
Transporter
O15244
S22A2_HUMAN
IC50
4.78
CHEMBL
Multidrug and toxin extrusion protein 1
Transporter
Q96FL8
S47A1_HUMAN
IC50
5.54
CHEMBL
Multidrug and toxin extrusion protein 2
Transporter
Q86VL8
S47A2_HUMAN
IC50
4.90
CHEMBL
Serine protease hepsin
Enzyme
P05981
HEPS_HUMAN
IC50
7.54
CHEMBL
Hepatocyte growth factor activator
Enzyme
Q04756
HGFA_HUMAN
IC50
4.49
CHEMBL
Prothrombin
Enzyme
P00734
THRB_HUMAN
IC50
4.50
CHEMBL
Transmembrane protease serine 2
Enzyme
O15393
TMPS2_HUMAN
INHIBITOR
IC50
6
IUPHAR
Plasminogen
Enzyme
PLMN_RAT
IC50
5.58
CHEMBL
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External reference:
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ID
Source
018673
NDDF
018674
NDDF
0FD207WKDU
UNII
1179628001
SNOMEDCT_US
1187213009
SNOMEDCT_US
1187214003
SNOMEDCT_US
2536
PUBCHEM_CID
5068
INN_ID
59721-29-8
SECONDARY_CAS_RN
6432
IUPHAR_LIGAND_ID
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Pharmaceutical products:
None
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Structure 🔎
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camostat