DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
Substructure SMILES Example:
n1cnccc1
gemigliptin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
dipeptidyl aminopeptidase-IV inhibitors
4833
911637-19-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
gemigliptin
zemiglo
LC15-0444
Dipeptidyl Peptidase IV Inhibitors; orally active small molecule for the treatment of type II diabetes
Molecular weight: 489.37
Formula: C18H19F8N5O2
CLOGP: 0.87
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 92.42
ALOGS: -3.77
ROTB: 6
Drug dosage:
Dose
Unit
Route
50
mg
O
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
June 27, 2012
Korean Food and Drug Administration (KFDA)
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1
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A10BD18
ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
ATC
A10BH06
ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors
ATC
A10BH52
ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Diabetes mellitus type 2
indication
44054006
DOID:9352
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.86
Basic
pKa2
0.44
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Dipeptidyl peptidase 4
Enzyme
P27487
DPP4_HUMAN
INHIBITOR
IC50
7.80
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Dipeptidyl peptidase 9
Enzyme
Q86TI2
DPP9_HUMAN
IC50
4.33
SCIENTIFIC LITERATURE
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External reference:
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ID
Source
11953153
PUBCHEM_CID
5DHU18M5D6
UNII
9291
INN_ID
C3501981
UMLSCUI
C534891
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:134731
CHEBI
CHEMBL3707235
ChEMBL_ID
D10502
KEGG_DRUG
DB12412
DRUGBANK_ID
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Pharmaceutical products:
None
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gemigliptin