captodiame 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
aptamers, classical and mirror ones 483 486-17-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • captodiamine hydrochloride
  • captodiame
  • captodiam
  • captodiamin
  • captodiamine
  • captodramin
  • captodramine
  • captodiamine HCl
Captodiamine represents an interesting strategy for achieving benzodiazepine substitution with a low risk of dependence or impairment of cognitive function
  • Molecular weight: 359.59
  • Formula: C21H29NS2
  • CLOGP: 6.41
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -6.78
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 58
kinase-selectivity-class GRK2,PDK4 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BB02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Diphenylmethane derivatives
CHEBI has role CHEBI:35474 anxiolytic drug

Related Drugs by ATC class:

N05BB Diphenylmethane derivatives 1 drug
hydroxyzine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anxiety disorder indication 197480006 DOID:2030




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.14 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07316 KEGG_DRUG
236176 RXNORM
C0301409 UMLSCUI
CHEBI:135521 CHEBI
CHEMBL2110809 ChEMBL_ID
CHEMBL2106143 ChEMBL_ID
DB09014 DRUGBANK_ID
10240 PUBCHEM_CID
625 INN_ID
H93K9455DD UNII
4025009 SNOMEDCT_US
C495502 MESH_SUPPLEMENTAL_RECORD_UI
005298 NDDF
005299 NDDF

Pharmaceutical products:

None