AI ASSISTANT
Ask DrugCentral
Explore drug information in your own words.
Type a question in the search bar above to get started. Each question is answered independently.
Try a sample question
Select a question to fill the search bar, then submit it or edit it first.
AI can make mistakes. Verify answers against the original sources before relying on them.
laninamivir octanoate hydrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antivirals neuraminidase inhibitors | 4822 | 203120-46-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an antiviral agent
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 40 | mg | Inhal.powder |
| 0.16 | g | Inhal.solution |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PLK1,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 50 | |||
| kinase-selectivity-class | AXL,EPHB4,GRK2,MAP2K6,MAPK7,STK33,TEK | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 10, 2010 | PMDA | Daiichi Sankyo Company, Limited |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J05AH04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Neuraminidase inhibitors |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
Related Drugs by ATC class:
J05AH Neuraminidase inhibitors 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Influenza | indication | 6142004 | DOID:8469 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.71 | acidic |
| pKa2 | 13.69 | acidic |
| pKa3 | 9.82 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Neuraminidase | Enzyme | IC50 | 8.89 | CHEMBL | |||||
| Neuraminidase | Enzyme | IC50 | 5.51 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D09547 | KEGG_DRUG |
| C4706204 | UMLSCUI |
| LVO | PDB_CHEM_ID |
| LNV | PDB_CHEM_ID |
| 46919879 | PUBCHEM_CID |
| CHEMBL467058 | ChEMBL_ID |
| C546918 | MESH_SUPPLEMENTAL_RECORD_UI |
| C546919 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11888 | DRUGBANK_ID |
| DB12791 | DRUGBANK_ID |
| C2931958 | UMLSCUI |
| CHEBI:134741 | CHEBI |
| CHEMBL466246 | ChEMBL_ID |
| 203120-17-6 | SECONDARY_CAS_RN |
| 502272 | PUBCHEM_CID |
| E026V904RL | UNII |
| 9047 | INN_ID |
| B408IW3GL5 | UNII |
Pharmaceutical products:
None