laninamivir octanoate hydrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals neuraminidase inhibitors 4822 203120-46-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • laninamivir octanoate hydrate
  • laninamivir octanoate
  • CS-8958
  • inavir
an antiviral agent
  • Molecular weight: 472.54
  • Formula: C21H36N4O8
  • CLOGP: -2.21
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 7
  • TPSA: 193.29
  • ALOGS: -3.41
  • ROTB: 7

Drug dosage:

DoseUnitRoute
40 mg Inhal.powder

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 10, 2010 PMDA Daiichi Sankyo Company, Limited

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AH04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Neuraminidase inhibitors
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Influenza indication 6142004 DOID:8469




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.71 acidic
pKa2 13.69 acidic
pKa3 9.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Neuraminidase Enzyme IC50 8.89 CHEMBL
Neuraminidase Enzyme IC50 5.51 CHEMBL

External reference:

IDSource
D09547 KEGG_DRUG
C4706204 UMLSCUI
CHEBI:134741 CHEBI
LVO PDB_CHEM_ID
LNV PDB_CHEM_ID
9847629 PUBCHEM_CID
CHEMBL467058 ChEMBL_ID
C546918 MESH_SUPPLEMENTAL_RECORD_UI
C546919 MESH_SUPPLEMENTAL_RECORD_UI
203120-17-6 SECONDARY_CAS_RN
E026V904RL UNII
502272 PUBCHEM_CID
DB11888 DRUGBANK_ID
DB12791 DRUGBANK_ID
C2931958 UMLSCUI
CHEMBL466246 ChEMBL_ID
9047 INN_ID
B408IW3GL5 UNII

Pharmaceutical products:

None