ipidacrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
acridine derivatives	4808	62732-44-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ipidacrine hydrochloride hydrate
CV71VTP0VN
ipidacrine
neuromidine
ipidacrine hydrochloride
NIK-247
amiridine
ipidacrine HCl

do not confuse with neuromedin

Molecular weight: 188.27
Formula: C12H16N2
CLOGP: 2.90
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 38.91
ALOGS: -2.07
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rehabilitation therapy	27.60	27.13	3	3	879	34956046

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06DA05	NERVOUS SYSTEM PSYCHOANALEPTICS ANTI-DEMENTIA DRUGS Anticholinesterases

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Alzheimer's disease	indication	26929004	DOID:10652

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.22	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.18		CHEMBL
Butyrylcholinesterase; Protein Bche	Enzyme		Q9JKC1_RAT		IC50	6.66		SCIENTIFIC LITERATURE
Acetylcholinesterase	Enzyme		ACES_ELEEL		IC50	6.77		CHEMBL
Cholinesterase	Enzyme		CHLE_HORSE		IC50	7.15		CHEMBL
Acetylcholinesterase	Enzyme		ACES_RAT		IC50	6.57		SCIENTIFIC LITERATURE

External reference:

ID	Source
CV71VTP0VN	UNII
D09750	KEGG_DRUG
C0051691	UMLSCUI
CHEBI:125612	CHEBI
CHEMBL130880	ChEMBL_ID
604519	PUBCHEM_CID
DB13668	DRUGBANK_ID
7385	INN_ID
C049860	MESH_SUPPLEMENTAL_RECORD_UI
R9W	PDB_CHEM_ID

Pharmaceutical products:

None