ipidacrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
acridine derivatives	4808	62732-44-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ipidacrine hydrochloride hydrate
CV71VTP0VN
ipidacrine
neuromidine
ipidacrine hydrochloride
NIK-247
amiridine
ipidacrine HCl

do not confuse with neuromedin

Molecular weight: 188.27
Formula: C12H16N2
CLOGP: 2.90
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 38.91
ALOGS: -2.07
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06DA05	NERVOUS SYSTEM PSYCHOANALEPTICS ANTI-DEMENTIA DRUGS Anticholinesterases

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Alzheimer's disease	indication	26929004	DOID:10652

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.22	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.18		CHEMBL
Acetylcholinesterase	Enzyme		ACES_ELEEL		IC50	6.77		CHEMBL
Cholinesterase	Enzyme		CHLE_HORSE		IC50	7.15		CHEMBL
Butyrylcholinesterase; Protein Bche	Enzyme		Q9JKC1_RAT		IC50	6.66		SCIENTIFIC LITERATURE
Acetylcholinesterase	Enzyme		ACES_RAT		IC50	6.57		SCIENTIFIC LITERATURE

External reference:

ID	Source
CV71VTP0VN	UNII
D09750	KEGG_DRUG
C0051691	UMLSCUI
CHEBI:125612	CHEBI
R9W	PDB_CHEM_ID
CHEMBL130880	ChEMBL_ID
604519	PUBCHEM_CID
DB13668	DRUGBANK_ID
C049860	MESH_SUPPLEMENTAL_RECORD_UI
7385	INN_ID

Pharmaceutical products:

None