ipidacrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 4808 62732-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ipidacrine hydrochloride hydrate
  • CV71VTP0VN
  • ipidacrine
  • neuromidine
  • ipidacrine hydrochloride
  • NIK-247
  • amiridine
  • ipidacrine HCl
do not confuse with neuromedin
  • Molecular weight: 188.27
  • Formula: C12H16N2
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 38.91
  • ALOGS: -2.07
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06DA05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTI-DEMENTIA DRUGS
Anticholinesterases

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Alzheimer's disease indication 26929004 DOID:10652

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme IC50 6.18 CHEMBL
Acetylcholinesterase Enzyme IC50 6.57 SCIENTIFIC LITERATURE
Butyrylcholinesterase; Protein Bche Enzyme IC50 6.66 SCIENTIFIC LITERATURE
Acetylcholinesterase Enzyme IC50 6.77 CHEMBL
Cholinesterase Enzyme IC50 7.15 CHEMBL

External reference:

IDSource
D09750 KEGG_DRUG
CV71VTP0VN UNII
7385 INN_ID
604519 PUBCHEM_CID
CHEBI:125612 CHEBI
CHEMBL130880 ChEMBL_ID
DB13668 DRUGBANK_ID
C049860 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None