tenidap Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4728 120210-48-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tenidap sodium
  • tenidap
  • Molecular weight: 320.75
  • Formula: C14H9ClN2O3S
  • CLOGP: 2.30
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 83.63
  • ALOGS: -4.53
  • ROTB: 1

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.11 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.06 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 22.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AX23 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.03 acidic
pKa2 13.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme IC50 6.57 DRUG MATRIX
Prostaglandin G/H synthase 1 Enzyme IC50 7.26 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 6.15 DRUG MATRIX
Cytochrome P450 1A2 Enzyme IC50 6 DRUG MATRIX
Inward rectifier potassium channel 4 Ion channel ACTIVATOR EC50 6.40 IUPHAR
Prostaglandin G/H synthase 1 Enzyme IC50 5.59 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.08 CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 5.05 CHEMBL
Cyclooxygenase Enzyme IC50 8 CHEMBL

External reference:

IDSource
D06072 KEGG_DRUG
9K7CJ74ONH UNII
6421 INN_ID
119784-94-0 SECONDARY_CAS_RN
CHEBI:35847 CHEBI
DB13481 DRUGBANK_ID
CHEMBL1908355 ChEMBL_ID
CHEMBL2104833 ChEMBL_ID
60712 PUBCHEM_CID
2395 IUPHAR_LIGAND_ID
C062866 MESH_SUPPLEMENTAL_RECORD_UI
008173 NDDF

Pharmaceutical products:

None