tonzonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quaternary ammonium compounds	4605	553-08-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tonzonium
thonzonium bromide
tonzonium bromide
thonzide
thonzonium

a surfactant with antifungal activity; also inhibits osteoclast formation

Molecular weight: 511.82
Formula: C32H55N4O
CLOGP: 6.43
LIPINSKI: 2
HAC: 5
HDO: 0
TPSA: 38.25
ALOGS: -7.48
ROTB: 22

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 17, 1962	FDA	PAR STERILE PRODUCTS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Mastoidectomy Cavity Infections	indication
Chronic purulent otitis media	off-label use	38394007	DOID:14247
Herpes zoster auricularis	contraindication	21954000	DOID:9210
Bullous myringitis	contraindication	33528003	DOID:13791
Perforation of tympanic membrane	contraindication	60442001
Herpes simplex	contraindication	88594005	DOID:8566
Tuberculosis of ear	contraindication	186269001
Viral ear infection	contraindication	312137007
Fungal ear infection	contraindication	312148000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.47	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin-degrading enzyme	Enzyme	P14735	IDE_HUMAN		EC50	4.27		CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Kinase		DYR1A_RAT		AC50	5.03		CHEMBL

External reference:

ID	Source
D02140	KEGG_DRUG
4018647	VUID
N0000146960	NUI
25466-36-8	SECONDARY_CAS_RN
4018647	VANDF
C0772395	UMLSCUI
CHEBI:94514	CHEBI
CHEMBL1201322	ChEMBL_ID
5456	PUBCHEM_CID
DB09552	DRUGBANK_ID
CHEMBL1200883	ChEMBL_ID
C000609116	MESH_SUPPLEMENTAL_RECORD_UI
221171	RXNORM
5576	MMSL
007523	NDDF
007524	NDDF
1559	INN_ID
JI2B19CR0R	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cortisporin-TC	HUMAN PRESCRIPTION DRUG LABEL	4	54868-0564	SUSPENSION	0.50 mg	AURICULAR (OTIC)	NDA	22 sections
Cortisporin TC	HUMAN PRESCRIPTION DRUG LABEL	4	63481-529	SUSPENSION	0.50 mg	AURICULAR (OTIC)	NDA	22 sections