diosmetin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4601 | 520-34-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a 5,7-dihydroxyflavone
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22586 | antioxidants |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:48422 | angiogenesis antagonist |
| CHEBI has role | CHEBI:50646 | antiosteoporotic |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
| CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:77307 | cardioprotective agents |
| CHEBI has role | CHEBI:140489 | TrkB receptor agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.68 | acidic |
| pKa2 | 9.12 | acidic |
| pKa3 | 10.43 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Multidrug resistance-associated protein 1 | Transporter | IC50 | 5.52 | CHEMBL | |||||
| Cytochrome P450 1B1 | Enzyme | IC50 | 7.54 | CHEMBL | |||||
| Lysine-specific histone demethylase 1A | Enzyme | IC50 | 4.55 | CHEMBL | |||||
| Inositol polyphosphate multikinase | Kinase | IC50 | 5.14 | CHEMBL | |||||
| Inositol hexakisphosphate kinase 2 | Kinase | IC50 | 6.05 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:4630 | CHEBI |
| J8D | PDB_CHEM_ID |
| CHEMBL90568 | ChEMBL_ID |
| C039602 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11259 | DRUGBANK_ID |
| TWZ37241OT | UNII |
| 1314347 | RXNORM |
| C0114217 | UMLSCUI |
| 5281612 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| GONGJINHYANG SEOL WHITENING | HUMAN OTC DRUG LABEL | 1 | 53208-372 | CREAM | 0.10 g | TOPICAL | OTC monograph not final | 12 sections |
| ISA KNOX WXII PLUS WHITENING REVOLUTION SERUM | HUMAN OTC DRUG LABEL | 1 | 53208-424 | CREAM | 0.11 mL | TOPICAL | OTC monograph not final | 10 sections |
| Whoo Gongjinhyang Seol Whitening Jin Essence | HUMAN OTC DRUG LABEL | 1 | 53208-427 | CREAM | 0.06 mL | TOPICAL | unapproved drug other | 12 sections |
| ISAKNOX X202 WHITENING SECRET ESSENCE | HUMAN OTC DRUG LABEL | 1 | 53208-531 | CREAM | 0.06 mL | TOPICAL | unapproved drug other | 9 sections |