levomethadone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4586	125-58-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

levomethadone
levomethadone hydrochloride
levomethadone HCl

Molecular weight: 309.45
Formula: C21H27NO
CLOGP: 4.17
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 20.31
ALOGS: -4.72
ROTB: 7

Drug dosage:

Dose	Unit	Route
15	mg	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Logorrhoea	146.90	67.30	29	958	2397	34953547
Aggression	135.47	67.30	48	939	38916	34917028
Restlessness	110.18	67.30	37	950	25445	34930499
Bradykinesia	100.28	67.30	23	964	3870	34952074
Dysarthria	98.92	67.30	37	950	34745	34921199
Drug abuse	95.18	67.30	49	938	99047	34856897
Bradyphrenia	90.36	67.30	22	965	4776	34951168
Substance abuse	71.00	67.30	20	967	7621	34948323

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aggression	211.71	68.89	62	1157	50896	79692273
Logorrhoea	172.24	68.89	33	1186	4332	79738837
Drug abuse	164.63	68.89	69	1150	162622	79580547
Restlessness	130.74	68.89	42	1177	46450	79696719
Patient uncooperative	130.44	68.89	20	1199	694	79742475
Dysarthria	115.32	68.89	42	1177	67580	79675589
Bradyphrenia	111.49	68.89	27	1192	10613	79732556
Bradykinesia	97.66	68.89	23	1196	8020	79735149
Substance abuse	96.52	68.89	24	1195	10502	79732667
Abnormal behaviour	86.53	68.89	29	1190	36392	79706777
Drug dependence	71.90	68.89	26	1193	40743	79702426

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N07BC05	NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS DRUGS USED IN ADDICTIVE DISORDERS Drugs used in opioid dependence
CHEBI has role	CHEBI:35482	narcotic analgesic
CHEBI has role	CHEBI:51177	anti-tussive
CHEBI has role	CHEBI:55322	mu-opioid agonists
CHEBI has role	CHEBI:60643	N-methyl-D-aspartate receptor antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Opioid dependence	indication	75544000	DOID:2559

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.55	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Opioid receptor	GPCR		OPRD_RAT OPRM_RAT OPRK_RAT SGMR1_RAT		Ki	8.70		CHEMBL

External reference:

ID	Source
D08121	KEGG_DRUG
5967-73-7	SECONDARY_CAS_RN
CHEBI:136003	CHEBI
CHEMBL159659	ChEMBL_ID
5002	INN_ID
DB13515	DRUGBANK_ID
6Y75Z4E8NS	UNII
236913	RXNORM
007175	NDDF
007176	NDDF
1156227003	SNOMEDCT_US
C0772241	UMLSCUI
22267	PUBCHEM_CID

Pharmaceutical products:

None