iclaprim 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antimicrobials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim analogues	4573	192314-93-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

iclaprim
iclaprim mesylate
iclaprim mesilate

has antiviral activity

Molecular weight: 354.41
Formula: C19H22N4O3
CLOGP: 2.64
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 105.51
ALOGS: -3.40
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01EA03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Trimethoprim and derivatives
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D005493	Folic Acid Antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.01	Basic
pKa2	0.6	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Dihydrofolate reductase	Enzyme	P00374	DYR_HUMAN		Ki	6.11		CHEMBL
Dihydrofolate reductase	Enzyme		DYR_PNECA		IC50	5.62		CHEMBL
Dihydrofolate reductase	Enzyme		DYR_ECOLI		IC50	8.15		CHEMBL
Dihydrofolate reductase	Enzyme		B0BL08_ECOLX		IC50	8.15		CHEMBL
Dihydrofolate reductase	Enzyme		DYR_STAAU		Ki	10.10		CHEMBL

External reference:

ID	Source
D08337	KEGG_DRUG
CHEMBL134561	ChEMBL_ID
C486448	MESH_SUPPLEMENTAL_RECORD_UI
10820	IUPHAR_LIGAND_ID
8315	INN_ID
474793-41-4	SECONDARY_CAS_RN
DB06358	DRUGBANK_ID
42445HUU0O	UNII
725576004	SNOMEDCT_US
C3654387	UMLSCUI
CHEMBL2105645	ChEMBL_ID
213043	PUBCHEM_CID

Pharmaceutical products:

None