iclaprim 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antimicrobials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim analogues 4573 192314-93-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iclaprim
  • iclaprim mesylate
  • iclaprim mesilate
has antiviral activity
  • Molecular weight: 354.41
  • Formula: C19H22N4O3
  • CLOGP: 2.64
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 105.51
  • ALOGS: -3.40
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01EA03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Trimethoprim and derivatives
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.01 Basic
pKa2 0.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydrofolate reductase Enzyme Ki 6.11 CHEMBL
Dihydrofolate reductase Enzyme IC50 5.62 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.15 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.15 CHEMBL
Dihydrofolate reductase Enzyme Ki 10.10 CHEMBL

External reference:

IDSource
D08337 KEGG_DRUG
CHEMBL134561 ChEMBL_ID
C486448 MESH_SUPPLEMENTAL_RECORD_UI
10820 IUPHAR_LIGAND_ID
8315 INN_ID
474793-41-4 SECONDARY_CAS_RN
DB06358 DRUGBANK_ID
42445HUU0O UNII
725576004 SNOMEDCT_US
C3654387 UMLSCUI
CHEMBL2105645 ChEMBL_ID
213043 PUBCHEM_CID

Pharmaceutical products:

None