fenbendazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anthelminthics, tiabendazole derivatives | 4536 | 43210-67-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antinematodal benzimidazole used in veterinary medicine.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P02CA06 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Benzimidazole derivatives |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| CHEBI has role | CHEBI:35444 | antinematodal drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Removal and control of lungworm, Dictyocaulus viviparus | Indication |
| Cattle | Removal and control of stomach worm (adults) | Indication |
| Cattle | Removal and control of brown stomach wormd, Ostertagia ostertagi | Indication |
| Cattle | Removal and control of stomach worms (adults and 4th-stage larvae) | Indication |
| Cattle | Removal and control of barberpole worms, H placei | Indication |
| Cattle | Removal and control of small stomach worms, Trichostrongylus axei | Indication |
| Cattle | Removal and control of intestinal worms (adults and 4th-stage larvae) | Indication |
| Cattle | Removal and control of hookworm, Bunostomum phlebotomum | Indication |
| Cattle | Removal and control of threadnecked intestinal worms, Nematodirus helvetianus | Indication |
| Cattle | Removal and control of small intestinal worms, Cooperia punctata | Indication |
| Cattle | Removal and control of bankrupt worms, Trichostrongylus colubriformis | Indication |
| Cattle | Removal and control of nodular worm, Oesophagostomum radiatum | Indication |
| Cattle | Removal and control of barberpole worms, H placei | Indication |
| Cattle | Removal and control of small intestinal worms, C oncophora | Indication |
| Goats | Removal and control of stomach worms, Haemonchus contortus (adults) | Indication |
| Goats | Removal and control of stomach worms, Teladorsagia circumcincta | Indication |
| Horses | Control of large strongyles, Strongylus edentatus | Indication |
| Horses | Control of small strongyles, Cyathostomum species | Indication |
| Horses | Control of pinworms, Oxyuris equi | Indication |
| Horses | Control of ascarids (Parascaris equorum) | Indication |
| Horses | Control of large strongyles, S equinus | Indication |
| Horses | Control of large strongyles, S vulgaris | Indication |
| Horses | Control of small strongyles, Cylicocyclus species | Indication |
| Horses | Control of small strongyles, Cylicostephanus species | Indication |
| Horses | Control of small strongyles, Triodontophorus species | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Panacur Suspension 10% | Intervet Inc. | 1 |
| Panacur Granules 22.2% | Intervet Inc. | 1 |
| panacur, safe-guard | Intervet Inc. | 1 |
| Panacur C (OTC), Safe-Guard Canine (OTC), Panacur Granules 22.2% (Rx) | Intervet Inc. | 1 |
| Safe-Guard , Panacur | Intervet Inc. | 1 |
| Safe-Guard | Intervet Inc. | 1 |
| Panacur 10% Paste, Safe-Guard | Intervet Inc. | 1 |
| Safe-Guard Type A Medicated Article | Intervet Inc. | 1 |
| Safe-Guard | Intervet Inc. | 1 |
| SAFE-GUARD plus LINCOMIX | Intervet Inc. | 2 |
| BMD / Safe-Guard | Zoetis Inc. | 2 |
| Panacur Plus | Intervet Inc. | 3 |
| Safe-Guard AquaSol | Intervet Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.61 | acidic |
| pKa2 | 13.2 | acidic |
| pKa3 | 3.71 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | Kinase | IC50 | 5.50 | DRUG MATRIX | |||||
| Beta-lactamase 1 | Enzyme | IC50 | 5.22 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| D04140 | KEGG_DRUG |
| N0000166935 | NUI |
| CHEBI:77092 | CHEBI |
| CHEMBL37161 | ChEMBL_ID |
| 3395 | INN_ID |
| DB11410 | DRUGBANK_ID |
| 621BVT9M36 | UNII |
| 4325 | RXNORM |
| NOCODE | MMSL |
| 013514 | NDDF |
| 96134008 | SNOMEDCT_US |
| C0015821 | UMLSCUI |
| D005273 | MESH_DESCRIPTOR_UI |
| 3334 | PUBCHEM_CID |
Pharmaceutical products:
None