All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hydrocortisone valerate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
corticosteroids, except prednisolone derivatives	4504	57524-89-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: hydrocortisone valerate hydrocortisone pentanoate	used in treatment of atopic dermatitis; RN given refers to 11beta-isomer Molecular weight: 446.58 Formula: C26H38O6 CLOGP: 4.01 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 100.90 ALOGS: -4.77 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.23 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
March 17, 1978	FDA	RANBAXY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteomyelitis	43.08	32.08	14	582	26006	63462420

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Psoriasis	63.15	32.66	24	569	89563	79654232
Periarthritis	33.43	32.66	7	586	2941	79740854

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D000893	Anti-Inflammatory Agents
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:50857	anti-allergic drugs
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:88188	allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.48	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
D02288	KEGG_DRUG
4017946	VUID
N0000179155	NUI
4017941	VANDF
4017946	VANDF
CHEBI:50865	CHEBI
CHEBI:17650	CHEBI
CHEMBL1200562	ChEMBL_ID
C038363	MESH_SUPPLEMENTAL_RECORD_UI
DB14544	DRUGBANK_ID
68717P8FUZ	UNII
DB00741	DRUGBANK_ID
27199	RXNORM
11849	MMSL
2500	MMSL
4837	MMSL
4844	MMSL
d00254	MMSL
002147	NDDF
002153	NDDF
16602005	SNOMEDCT_US
396458002	SNOMEDCT_US
51612003	SNOMEDCT_US
C0063079	UMLSCUI
C0020268	UMLSCUI
5282494	PUBCHEM_CID
38	INN_ID
5754	PUBCHEM_CID
D006854	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0560	OINTMENT	2 mg	TOPICAL	ANDA	21 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0560	OINTMENT	2 mg	TOPICAL	ANDA	21 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0668	CREAM	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0669	OINTMENT	2 mg	TOPICAL	ANDA	22 sections
HYDROCORTISONE VALERATE	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0720	CREAM	2 mg	TOPICAL	ANDA	18 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-730	CREAM	2 mg	TOPICAL	ANDA	22 sections
hydrocortisone valerate cream	HUMAN PRESCRIPTION DRUG LABEL	1	21922-007	CREAM	2 mg	TOPICAL	ANDA	18 sections
hydrocortisone valerate cream	HUMAN PRESCRIPTION DRUG LABEL	1	21922-007	CREAM	2 mg	TOPICAL	ANDA	18 sections
hydrocortisone valerate cream	HUMAN PRESCRIPTION DRUG LABEL	1	21922-007	CREAM	2 mg	TOPICAL	ANDA	18 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-455	CREAM	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-455	CREAM	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2525	CREAM	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1290	CREAM	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1290	CREAM	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1292	OINTMENT	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1292	OINTMENT	2 mg	TOPICAL	ANDA	22 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	54868-4451	CREAM	2 mg	TOPICAL	ANDA	11 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5251	OINTMENT	2 mg	TOPICAL	ANDA	11 sections
HYDROCORTISONE VALERATE	HUMAN PRESCRIPTION DRUG LABEL	1	61919-010	CREAM	2 mg	TOPICAL	ANDA	10 sections
HYDROCORTISONE VALERATE	HUMAN PRESCRIPTION DRUG LABEL	1	68180-954	CREAM	2 mg	TOPICAL	ANDA	18 sections
Hydrocortisone valerate	HUMAN PRESCRIPTION DRUG LABEL	1	68462-575	CREAM	2 mg	TOPICAL	ANDA	19 sections
Hydrocortisone Valerate	HUMAN PRESCRIPTION DRUG LABEL	1	68462-836	OINTMENT	2 mg	TOPICAL	ANDA	19 sections