sulfisoxazole acetyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4458	80-74-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sulfisoxazole acetyl
acetylsulfisoxazole
gantrisin

Molecular weight: 309.34
Formula: C13H15N3O4S
CLOGP: 1.03
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 106.50
ALOGS: -3.36
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
fu (Fraction unbound in plasma)	0 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

Date	Agency	Company	Orphan
Dec. 4, 1953	FDA	ROCHE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000890	Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.49	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Endothelin-1 receptor	GPCR	P25101	EDNRA_HUMAN		IC50	6.11		CHEMBL
Endothelin B receptor	GPCR	P24530	EDNRB_HUMAN		IC50	4.62		CHEMBL
Dihydropteroate synthase	Enzyme		DHPS_ECOLI	INHIBITOR				CHEMBL	CHEMBL
Endothelin-1 receptor	GPCR		EDNRA_RAT		IC50	6.11		CHEMBL

External reference:

ID	Source
D05956	KEGG_DRUG
4017766	VUID
N0000179292	NUI
4017766	VANDF
CHEBI:135975	CHEBI
CHEMBL1200910	ChEMBL_ID
DB14033	DRUGBANK_ID
C005387	MESH_SUPPLEMENTAL_RECORD_UI
WBT5QH3KED	UNII
6662	PUBCHEM_CID
224975	RXNORM
3965	MMSL
499	MMSL
5532	MMSL
002819	NDDF
88757004	SNOMEDCT_US
C0081437	UMLSCUI
D013444	MESH_DESCRIPTOR_UI
CHEMBL453	ChEMBL_ID
CHEMBL1200321	ChEMBL_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ERYTHROMYCIN ETHYLSUCCINATE AND SULFISOXAZOLE ACETYL	HUMAN PRESCRIPTION DRUG LABEL	2	21695-690	GRANULE, FOR SUSPENSION	600 mg	ORAL	ANDA	26 sections
ERYTHROMYCIN ETHYLSUCCINATE AND SULFISOXAZOLE ACETYL	HUMAN PRESCRIPTION DRUG LABEL	2	54868-0971	GRANULE, FOR SUSPENSION	600 mg	ORAL	ANDA	26 sections