All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

bufylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
N-methylated xanthine derivatives	4426	5634-34-4

Description:

Molecule	Description
Synonyms: bufylline ambuphylline butaphyllamine theophylline aminoisobutanol	Molecular weight: 269.31 Formula: C11H19N5O3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 69.30 ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03DA10	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D014665	Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Phosphodiesterase 4	Enzyme	P27815 Q07343 Q08493 Q08499	PDE4A_HUMAN PDE4B_HUMAN PDE4C_HUMAN PDE4D_HUMAN	INHIBITOR	Ki	4.25		CHEMBL	CHEMBL
Adenosine receptor A1	GPCR	P30542	AA1R_HUMAN	ANTAGONIST	Ki	9.22		CHEMBL	CHEMBL
Adenosine receptor A2b	GPCR	P29275	AA2BR_HUMAN	ANTAGONIST	Ki	5.57		CHEMBL	CHEMBL
Adenosine A2 receptor	GPCR	P29274 P29275	AA2AR_HUMAN AA2BR_HUMAN	ANTAGONIST	Ki	4.85		CHEMBL	CHEMBL
Phosphodiesterase 3	Enzyme	Q13370 Q14432	PDE3B_HUMAN PDE3A_HUMAN	INHIBITOR				CHEMBL	CHEMBL
Adenosine receptor A2a	GPCR	P29274	AA2AR_HUMAN	ANTAGONIST	Ki	9.22		CHEMBL	CHEMBL
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN	ANTAGONIST	Ki	7.85		CHEMBL
Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	P05186	PPBT_HUMAN		Ki	4.09		CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Kinase	O00329	PK3CD_HUMAN		IC50	4.12		CHEMBL
Uncharacterized protein	Enzyme		E1BN64_BOVIN		Ki	4.11		CHEMBL
Adenosine receptor A3	GPCR		AA3R_RAT		Ki	4.07		CHEMBL
Adenosine receptor A1	GPCR		AA1R_BOVIN		Ki	5.42		CHEMBL
Adenosine receptor A1	GPCR		AA1R_CAVPO		Ki	5.01		CHEMBL
Adenosine A2 receptor	GPCR		AA2BR_RAT AA2AR_RAT		Ki	5.88		CHEMBL
Adenosine A2b receptor	GPCR		AA2BR_RAT		Ki	4.82		CHEMBL
Adenosine receptor	GPCR		AA1R_RAT AA3R_RAT AA2BR_RAT AA2AR_RAT		Ki	4.70		CHEMBL
Heart phosphodiesterase	Enzyme		E1BN64_BOVIN PDE1A_BOVIN PDE1B_BOVIN		IC50	4.04		CHEMBL
Adenosine A2a receptor	GPCR		AA2AR_CAVPO		Ki	4.89		CHEMBL
Adenosine receptor A1	GPCR		AA1R_RAT		Ki	6.15		CHEMBL
Adenosine receptor A2a	GPCR		AA2AR_RAT		Ki	5.17		CHEMBL

External reference:

ID	Source
D02884	KEGG_DRUG
C3652921	UMLSCUI
CHEMBL2104089	ChEMBL_ID
DB13812	DRUGBANK_ID
C006485	MESH_SUPPLEMENTAL_RECORD_UI
21850	PUBCHEM_CID
006001	NDDF
7302008	SNOMEDCT_US
VOU5V0B772	UNII

Pharmaceutical products:

None