cobamamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4404	13870-90-1

Description:

Molecule

Description

Synonyms:

cobamamide
adenosylcobalamin
cobalamin coenzyme
Vitamin B12 coenzyme

Molecular weight: 1579.61
Formula: C72H100CoN18O17P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 608.02
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ejection fraction abnormal	66.06	40.49	13	1052	1772	63486185
Sensitisation	57.77	40.49	13	1052	3373	63484584
Polycystic ovaries	54.17	40.49	13	1052	4458	63483499
Carpal tunnel syndrome	49.53	40.49	17	1048	20800	63467157
Dementia	43.35	40.49	15	1050	18779	63469178
Rhinitis allergic	41.76	40.49	13	1052	11714	63476243
Sleep disorder due to a general medical condition	41.26	40.49	13	1052	12175	63475782

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ultrasound antenatal screen	96.65	79.37	15	545	541	34955830
Trisomy 18	91.75	79.37	15	545	756	34955615
Hydrops foetalis	89.99	79.37	15	545	852	34955519
Cleft lip and palate	89.23	79.37	15	545	897	34955474

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hydrops foetalis	102.11	38.72	17	1572	761	79742038
Trisomy 18	99.04	38.72	16	1573	593	79742206
Ultrasound antenatal screen	96.98	38.72	16	1573	677	79742122
Cleft lip and palate	96.86	38.72	16	1573	682	79742117
Ejection fraction abnormal	59.75	38.72	13	1576	2427	79740372
Sensitisation	55.80	38.72	13	1576	3298	79739501
Polycystic ovaries	54.09	38.72	13	1576	3766	79739033
Foetal exposure during pregnancy	48.59	38.72	13	1576	5777	79737022
Needle fatigue	46.99	38.72	9	1580	893	79741906
Gait spastic	44.45	38.72	9	1580	1188	79741611
Relapsing-remitting multiple sclerosis	42.31	38.72	9	1580	1510	79741289
Rhinitis allergic	38.95	38.72	13	1576	12256	79730543

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03BA04	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS VITAMIN B12 AND FOLIC ACID Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role	CHEBI:23354	coenzymes
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:26348	prosthetic groups
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Prevention of Vitamin B12 Deficiency	indication
Hypokalemia	contraindication	43339004
Gastrectomy	contraindication	53442002
Leber's optic atrophy	contraindication	58610003	DOID:705
Atrophic gastritis	contraindication	84568007	DOID:8929

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D00042	KEGG_DRUG
C0056039	UMLSCUI
CHEBI:18408	CHEBI
B1Z	PDB_CHEM_ID
CHEMBL3833359	ChEMBL_ID
DB11191	DRUGBANK_ID
C000913	MESH_SUPPLEMENTAL_RECORD_UI
1915	INN_ID
F0R1QK73KB	UNII
131635025	PUBCHEM_CID
21373	RXNORM
NOCODE	MMSL
004345	NDDF
259509008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
EnBrace HR	HUMAN PRESCRIPTION DRUG LABEL	16	64661-650	CAPSULE, DELAYED RELEASE PELLETS	50 ug	ORAL	UNAPPROVED DRUG OTHER	11 sections
EnBrace HR	HUMAN PRESCRIPTION DRUG LABEL	16	64661-650	CAPSULE, DELAYED RELEASE PELLETS	50 ug	ORAL	UNAPPROVED DRUG OTHER	11 sections
EnBrace HR	HUMAN PRESCRIPTION DRUG LABEL	16	64661-650	CAPSULE, DELAYED RELEASE PELLETS	50 ug	ORAL	UNAPPROVED DRUG OTHER	11 sections
EnLyte	HUMAN PRESCRIPTION DRUG LABEL	18	64661-711	CAPSULE, DELAYED RELEASE PELLETS	50 ug	ORAL	unapproved drug other	12 sections
Biopar delta-FORTE	HUMAN PRESCRIPTION DRUG LABEL	6	64661-793	CAPSULE	50 ug	ORAL	unapproved drug other	11 sections
Biopar delta-FORTE	HUMAN PRESCRIPTION DRUG LABEL	6	64661-793	CAPSULE	50 ug	ORAL	unapproved drug other	11 sections
Biopar delta-FORTE	HUMAN PRESCRIPTION DRUG LABEL	6	64661-793	CAPSULE	50 ug	ORAL	unapproved drug other	11 sections