All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

cisplatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastic agents, platinum derivatives	4392	15663-27-1

Description:

Molecule

Description

Synonyms: cisplatin platinum diamminodichloride cis-Platinum

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Molecular weight: 300.05 Formula: Cl2H6N2Pt CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	2.53 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	2.30 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	4.75 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Dec. 19, 1978	FDA	HQ SPCLT PHARMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1196.26	15.18	945	58515	117504	63312058
Neutropenia	1169.36	15.18	1102	58358	173903	63255659
Disease progression	1092.92	15.18	910	58550	121848	63307714
Thrombocytopenia	833.89	15.18	858	58602	150299	63279263
Malignant neoplasm progression	676.97	15.18	583	58877	81538	63348024
Haematotoxicity	573.12	15.18	243	59217	9133	63420429
Mucosal inflammation	552.89	15.18	411	59049	46517	63383045
Bone marrow failure	539.09	15.18	338	59122	28952	63400610
Anaemia	474.86	15.18	924	58536	292506	63137056
Ototoxicity	426.69	15.18	120	59340	1242	63428320
Myelosuppression	419.79	15.18	267	59193	23436	63406126
Vomiting	416.66	15.18	1307	58153	558310	62871252
Pancytopenia	416.44	15.18	483	58977	96450	63333112
Leukopenia	300.26	15.18	366	59094	76924	63352638
Arthralgia	297.83	15.18	83	59377	569627	62859935
Acute myeloid leukaemia	283.46	15.18	185	59275	16962	63412600
Nausea	281.77	15.18	1553	57907	852918	62576644
Dehydration	276.16	15.18	543	58917	172811	63256751
Posterior reversible encephalopathy syndrome	264.60	15.18	178	59282	17167	63412395
Off label use	255.69	15.18	1275	58185	673187	62756375
Second primary malignancy	249.32	15.18	130	59330	7823	63421739
Hypomagnesaemia	242.49	15.18	207	59253	28530	63401032
Neutrophil count decreased	241.91	15.18	281	59179	56125	63373437
Joint swelling	238.53	15.18	18	59442	327648	63101914
Hypokalaemia	229.11	15.18	375	59085	103429	63326133
Rheumatoid arthritis	222.06	15.18	3	59457	253816	63175746
Diffuse large B-cell lymphoma recurrent	207.10	15.18	79	59381	2241	63427321
Renal salt-wasting syndrome	202.87	15.18	50	59410	292	63429270
Myelodysplastic syndrome	195.49	15.18	146	59314	16608	63412954
Neoplasm progression	195.18	15.18	204	59256	36224	63393338
Pain	192.24	15.18	248	59212	740380	62689182
Abdominal discomfort	184.52	15.18	38	59422	320847	63108715
Arthropathy	182.50	15.18	9	59451	234783	63194779
Deafness	169.41	15.18	138	59322	17819	63411743
Product dose omission issue	161.90	15.18	16	59444	234297	63195265
Metastases to central nervous system	161.43	15.18	118	59342	12987	63416575
Contraindicated product administered	161.04	15.18	11	59449	217637	63211925
Platelet count decreased	159.05	15.18	342	59118	115780	63313782
Nephropathy toxic	158.43	15.18	103	59357	9376	63420186
Peripheral swelling	155.97	15.18	30	59430	265912	63163650
Neutropenic sepsis	152.28	15.18	125	59335	16313	63413249
Musculoskeletal stiffness	150.42	15.18	5	59455	184613	63244949
Therapy partial responder	149.80	15.18	104	59356	10554	63419008
Drug resistance	149.71	15.18	143	59317	22790	63406772
Aortic thrombosis	149.10	15.18	51	59409	1048	63428514
Metastases to lung	148.51	15.18	111	59349	12639	63416923
Therapeutic product effect decreased	148.23	15.18	8	59452	193179	63236383
Sepsis	147.13	15.18	393	59067	152730	63276832
Fall	145.92	15.18	94	59366	392240	63037322
Acute kidney injury	144.13	15.18	557	58903	262858	63166704
Swelling	141.90	15.18	41	59419	275337	63154225
Gastrointestinal toxicity	141.49	15.18	89	59371	7652	63421910
Hyponatraemia	134.64	15.18	313	59147	111587	63317975
Oesophagitis	128.40	15.18	109	59351	14899	63414663
Teratoma	124.59	15.18	29	59431	127	63429435
Neurotoxicity	124.51	15.18	113	59347	16877	63412685
Pulmonary embolism	122.85	15.18	310	59150	116374	63313188
Hypocalcaemia	122.74	15.18	150	59310	31563	63397999
Ovarian germ cell teratoma	120.97	15.18	25	59435	53	63429509
Nasopharyngitis	120.14	15.18	44	59416	254213	63175349
Weight increased	120.11	15.18	47	59413	260745	63168817
Cardiotoxicity	117.79	15.18	82	59378	8356	63421206
Diffuse large B-cell lymphoma refractory	117.45	15.18	44	59416	1186	63428376
Drug hypersensitivity	114.68	15.18	75	59385	310612	63118950
Pyrexia	114.08	15.18	792	58668	469686	62959876
Urogenital fistula	113.40	15.18	29	59431	201	63429361
Wound	110.53	15.18	12	59448	163251	63266311
Pain in extremity	109.42	15.18	90	59370	331396	63098166
Headache	108.35	15.18	274	59186	632967	62796595
Neuropathy peripheral	105.36	15.18	288	59172	113379	63316183
Metastases to liver	103.35	15.18	119	59341	23520	63406042
Renal failure	103.04	15.18	292	59168	117360	63312202
Cardiomyopathy	102.36	15.18	103	59357	17481	63412081
Septic shock	101.41	15.18	205	59255	66424	63363138
Rash	100.36	15.18	237	59223	560634	62868928
Tumour lysis syndrome	99.67	15.18	76	59384	8914	63420648
Hydronephrosis	98.59	15.18	81	59379	10581	63418981
White blood cell count decreased	98.15	15.18	320	59140	138784	63290778
Pruritus	96.57	15.18	118	59342	361335	63068227
Sinusitis	93.14	15.18	48	59412	226605	63202957
Pericarditis	90.79	15.18	9	59451	131570	63297992
Condition aggravated	89.94	15.18	149	59311	402068	63027494
Contusion	89.89	15.18	16	59444	150028	63279534
Metastases to lymph nodes	88.32	15.18	68	59392	8090	63421472
Arthritis	88.27	15.18	5	59455	115916	63313646
Asthma	87.30	15.18	9	59451	127552	63302010
Product use in unapproved indication	86.10	15.18	364	59096	178716	63250846
Polyneuropathy	85.92	15.18	86	59374	14503	63415059
Hepatic enzyme increased	85.91	15.18	41	59419	202287	63227275
Drug intolerance	84.29	15.18	99	59361	308562	63121000
Disease recurrence	84.17	15.18	117	59343	27913	63401649
Insomnia	82.08	15.18	50	59410	215202	63214360
Blister	81.89	15.18	12	59448	129802	63299760
Metastases to skin	81.78	15.18	37	59423	1626	63427936
Oesophageal fistula	81.44	15.18	21	59439	151	63429411
Electrolyte imbalance	81.01	15.18	97	59363	19979	63409583
Migraine	80.12	15.18	4	59456	103342	63326220
Hypophagia	80.05	15.18	121	59339	31138	63398424
Renal impairment	80.00	15.18	222	59238	88133	63341429
Injection site pain	79.60	15.18	13	59447	129787	63299775
Discomfort	72.46	15.18	33	59427	167341	63262221
Teratoma benign	71.36	15.18	16	59444	57	63429505
Infusion related reaction	71.12	15.18	75	59385	245446	63184116
Renal tubular disorder	70.48	15.18	39	59421	2643	63426919
Muscle spasms	70.44	15.18	29	59431	156121	63273441
Metastases to bone	69.59	15.18	92	59368	20927	63408635
Ascites	68.85	15.18	131	59329	40597	63388965
Tinnitus	68.31	15.18	121	59339	35507	63394055
Palmar-plantar erythrodysaesthesia syndrome	67.51	15.18	95	59365	22920	63406642
Febrile bone marrow aplasia	66.37	15.18	55	59405	7270	63422292
Pleural effusion	65.32	15.18	214	59246	92996	63336566
Osteoarthritis	64.53	15.18	7	59453	95336	63334226
Loss of personal independence in daily activities	63.71	15.18	8	59452	97282	63332280
Gastrointestinal perforation	63.45	15.18	40	59420	3451	63426111
Lymphoma	63.02	15.18	67	59393	12120	63417442
Radiation skin injury	62.83	15.18	26	59434	917	63428645
Fibromyalgia	62.69	15.18	3	59457	80417	63349145
Cytopenia	60.38	15.18	64	59396	11537	63418025
Urticaria	59.79	15.18	41	59419	165761	63263801
Leukoencephalopathy	59.53	15.18	42	59418	4371	63425191
Renal tubular necrosis	59.13	15.18	64	59396	11814	63417748
Mobility decreased	58.83	15.18	20	59440	121139	63308423
Metastases to breast	56.70	15.18	18	59442	290	63429272
Decreased appetite	56.19	15.18	415	59045	250637	63178925
Gait disturbance	55.25	15.18	54	59406	183124	63246438
Deafness bilateral	55.23	15.18	27	59433	1415	63428147
Ovarian cancer recurrent	54.40	15.18	24	59436	993	63428569
Diarrhoea	54.19	15.18	955	58505	714411	62715151
Alopecia	52.31	15.18	153	59307	337383	63092179
Large intestine perforation	51.79	15.18	51	59409	8431	63421131
Feeling abnormal	51.79	15.18	38	59422	148354	63281208
Depression	50.46	15.18	66	59394	196426	63233136
Inappropriate antidiuretic hormone secretion	50.14	15.18	67	59393	15395	63414167
Abdominal pain	50.00	15.18	456	59004	293000	63136562
Encephalopathy	49.68	15.18	111	59349	38509	63391053
Fatigue	49.63	15.18	563	58897	887465	62542097
Metastases to peritoneum	49.33	15.18	34	59426	3408	63426154
Overdose	49.31	15.18	23	59437	115055	63314507
Bronchitis	49.03	15.18	28	59432	124907	63304655
Blood creatinine increased	48.91	15.18	187	59273	87657	63341905
Blood cholesterol increased	48.37	15.18	14	59446	94018	63335544
Injury	48.01	15.18	6	59454	73241	63356321
Deep vein thrombosis	47.99	15.18	180	59280	83620	63345942
Myasthenia gravis crisis	47.74	15.18	18	59442	494	63429068
Injection site erythema	47.41	15.18	10	59450	83164	63346398
Haemoglobin decreased	47.01	15.18	264	59196	145221	63284341
Adverse drug reaction	46.65	15.18	9	59451	79705	63349857
Suicidal ideation	46.58	15.18	3	59457	62418	63367144
Ileus	46.52	15.18	63	59397	14662	63414900
Lower respiratory tract infection	46.01	15.18	34	59426	132273	63297289
Drug clearance decreased	45.77	15.18	24	59436	1460	63428102
Anastomotic leak	45.31	15.18	17	59443	460	63429102
Hospitalisation	45.00	15.18	12	59448	85069	63344493
Peripheral artery thrombosis	44.93	15.18	26	59434	1920	63427642
Dizziness	43.54	15.18	231	59229	429694	62999868
Exposure during pregnancy	43.37	15.18	49	59411	155498	63274064
Folliculitis	43.19	15.18	7	59453	70310	63359252
Wheezing	42.70	15.18	18	59442	95577	63333985
Nasal abscess	42.37	15.18	13	59447	186	63429376
Mesenteric abscess	41.97	15.18	11	59449	85	63429477
Somnolence	40.97	15.18	65	59395	178620	63250942
Metastasis	40.91	15.18	36	59424	5161	63424401
Neutropenic colitis	40.69	15.18	29	59431	3066	63426496
Chemical peritonitis	40.29	15.18	11	59449	101	63429461
Malignant transformation	40.12	15.18	15	59445	402	63429160
Maternal exposure during pregnancy	40.00	15.18	92	59368	219970	63209592
Intentional product misuse	39.90	15.18	5	59455	60912	63368650
Blood lactate dehydrogenase increased	39.86	15.18	75	59385	23041	63406521
Cystitis haemorrhagic	39.54	15.18	32	59428	4091	63425471
Large intestinal ulcer perforation	39.39	15.18	10	59450	67	63429495
Nasal congestion	39.31	15.18	7	59453	65653	63363909
Balance disorder	39.17	15.18	15	59445	84407	63345155
Cataract	39.08	15.18	4	59456	57049	63372513
Venoocclusive liver disease	39.08	15.18	34	59426	4801	63424761
Gastrointestinal fungal infection	38.89	15.18	14	59446	336	63429226
Bicytopenia	38.89	15.18	26	59434	2479	63427083
Adverse event	38.75	15.18	8	59452	67551	63362011
Performance status decreased	38.38	15.18	30	59430	3648	63425914
Drug ineffective	38.19	15.18	720	58740	1044045	62385517
Wernicke's encephalopathy	37.79	15.18	8	59452	20	63429542
Gastric perforation	37.62	15.18	22	59438	1657	63427905
Metastases to adrenals	37.55	15.18	17	59443	748	63428814
Cardiac tamponade	37.44	15.18	33	59427	4742	63424820
Varicella zoster virus infection	37.22	15.18	26	59434	2663	63426899
Cervix neoplasm	37.14	15.18	12	59448	205	63429357
Dermatitis	36.99	15.18	61	59399	16897	63412665
Ureteric rupture	36.98	15.18	7	59453	7	63429555
Recall phenomenon	36.91	15.18	16	59444	634	63428928
Stress	36.43	15.18	9	59451	67158	63362404
Anxiety	36.36	15.18	95	59365	217446	63212116
Embryonal rhabdomyosarcoma	36.04	15.18	7	59453	9	63429553
Nephritis bacterial	36.01	15.18	8	59452	27	63429535
Asthenia	35.98	15.18	531	58929	383073	63046489
Memory impairment	35.98	15.18	27	59433	104231	63325331
Bladder perforation	35.88	15.18	11	59449	157	63429405
Injection site reaction	35.56	15.18	6	59454	58518	63371044
Treatment failure	35.54	15.18	84	59376	198959	63230603
Axillary vein thrombosis	35.36	15.18	13	59447	332	63429230
Hypoalbuminaemia	35.02	15.18	49	59411	11756	63417806
Peripheral ischaemia	34.87	15.18	32	59428	4846	63424716
Impaired healing	34.82	15.18	27	59433	102515	63327047
Metastases to abdominal wall	34.36	15.18	10	59450	118	63429444
Dysphagia	34.27	15.18	169	59291	88416	63341146
Unevaluable event	34.19	15.18	4	59456	51382	63378180
Radiation injury	34.18	15.18	14	59446	481	63429081
Stress cardiomyopathy	33.83	15.18	43	59417	9407	63420155
Melanoderma	33.67	15.18	11	59449	195	63429367
Respiratory failure	33.66	15.18	186	59274	101672	63327890
Multiple organ dysfunction syndrome	33.40	15.18	123	59337	56629	63372933
Cerebral venous thrombosis	33.34	15.18	22	59438	2052	63427510
Sinus polyp	33.33	15.18	13	59447	392	63429170
Inappropriate schedule of product administration	33.28	15.18	29	59431	103936	63325626
Malaise	33.01	15.18	241	59219	415713	63013849
Tumour haemorrhage	32.97	15.18	20	59440	1611	63427951
Cerebellar haemangioma	32.45	15.18	9	59451	88	63429474
Product use issue	31.96	15.18	103	59357	220417	63209145
Chloroma	31.89	15.18	11	59449	232	63429330
Haemolytic uraemic syndrome	31.87	15.18	23	59437	2480	63427082
Hypoaesthesia	31.74	15.18	69	59391	168324	63261238
Embolism	31.56	15.18	38	59422	7868	63421694
Gastrooesophageal reflux disease	31.44	15.18	26	59434	95613	63333949
Radiation oesophagitis	31.37	15.18	12	59448	343	63429219
Haemophagocytic lymphohistiocytosis	31.36	15.18	44	59416	10583	63418979
Herpes simplex encephalitis	31.24	15.18	12	59448	347	63429215
Malnutrition	30.67	15.18	53	59407	15245	63414317
Abortion spontaneous	30.60	15.18	4	59456	47191	63382371
Pneumonitis	30.38	15.18	87	59373	35135	63394427
Hypersensitivity	30.30	15.18	156	59304	292529	63137033
Systemic infection	30.29	15.18	29	59431	4631	63424931
Peripheral sensory neuropathy	30.05	15.18	36	59424	7415	63422147
Disseminated intravascular coagulation	29.42	15.18	59	59401	18992	63410570
Cytokine release syndrome	29.23	15.18	50	59410	14264	63415298
Wrong technique in product usage process	29.04	15.18	11	59449	62329	63367233
Chronic kidney disease	28.93	15.18	101	59359	45297	63384265
Pericardial effusion	28.65	15.18	77	59383	29981	63399581
Osteoporosis	28.64	15.18	9	59451	57329	63372233
Neoplasm recurrence	28.58	15.18	22	59438	2616	63426946
Enteritis	28.56	15.18	37	59423	8249	63421313
Bacteraemia	28.33	15.18	55	59405	17293	63412269
Metastases to abdominal cavity	28.31	15.18	12	59448	450	63429112
Arteriospasm coronary	28.30	15.18	26	59434	3942	63425620
Sleep disorder	28.30	15.18	21	59439	81545	63348017
White blood cell count abnormal	28.25	15.18	32	59428	6210	63423352
Acoustic stimulation tests abnormal	28.00	15.18	8	59452	88	63429474
Unmasking of previously unidentified disease	27.88	15.18	15	59445	961	63428601
Acquired gene mutation	27.78	15.18	15	59445	968	63428594
Enterococcal sepsis	27.67	15.18	17	59443	1401	63428161
Enterocolitis infectious	27.66	15.18	18	59442	1640	63427922
Vena cava thrombosis	27.63	15.18	20	59440	2167	63427395
Procalcitonin abnormal	27.55	15.18	6	59454	18	63429544
Intestinal perforation	27.40	15.18	44	59416	11919	63417643
Vesical fistula	27.37	15.18	8	59452	96	63429466
Alveolar soft part sarcoma	27.14	15.18	8	59452	99	63429463
Type 2 diabetes mellitus	26.99	15.18	13	59447	63855	63365707
Neutrophil count abnormal	26.79	15.18	22	59438	2870	63426692
Metastases to meninges	26.67	15.18	21	59439	2581	63426981
Pneumonia salmonella	26.41	15.18	5	59455	5	63429557
Cannabinoid hyperemesis syndrome	26.38	15.18	7	59453	57	63429505
Suicide attempt	26.36	15.18	12	59448	60906	63368656
Cholangitis	26.01	15.18	29	59431	5532	63424030
Radiation pneumonitis	25.96	15.18	17	59443	1566	63427996
Thymus enlargement	25.91	15.18	8	59452	117	63429445
Osteoradionecrosis	25.85	15.18	8	59452	118	63429444
Thrombotic microangiopathy	25.79	15.18	40	59420	10521	63419041
Clostridium bacteraemia	25.78	15.18	9	59451	197	63429365
Extremity necrosis	25.66	15.18	17	59443	1596	63427966
Incorrect dose administered	25.66	15.18	12	59448	59956	63369606
Acute respiratory distress syndrome	25.22	15.18	63	59397	23471	63406091
Klebsiella test positive	25.15	15.18	15	59445	1172	63428390
Osteosarcoma	25.08	15.18	8	59452	131	63429431
Amputation stump pain	24.96	15.18	6	59454	31	63429531
Hepatic function abnormal	24.86	15.18	84	59376	37058	63392504
Influenza like illness	24.78	15.18	16	59444	66808	63362754
Radiation proctitis	24.73	15.18	5	59455	9	63429553
Cervix carcinoma recurrent	24.43	15.18	8	59452	143	63429419
Bursitis	24.36	15.18	3	59457	37038	63392524
Jaw operation	24.08	15.18	13	59447	839	63428723
Road traffic accident	24.01	15.18	3	59457	36629	63392933
Fluid retention	23.95	15.18	13	59447	59673	63369889
Lymphopenia	23.93	15.18	53	59407	18274	63411288
Stem cell transplant	23.79	15.18	17	59443	1805	63427757
Blood pressure fluctuation	23.62	15.18	7	59453	46310	63383252
Influenza	23.56	15.18	41	59419	108681	63320881
Fistula of small intestine	23.51	15.18	10	59450	378	63429184
Cytomegalovirus oesophagitis	23.47	15.18	9	59451	259	63429303
Hypophosphataemia	23.45	15.18	40	59420	11386	63418176
Aortic embolus	23.41	15.18	6	59454	42	63429520
Malignant peritoneal neoplasm	23.27	15.18	12	59448	705	63428857
Cerebral ischaemia	23.12	15.18	30	59430	6698	63422864
Anti-Muellerian hormone level decreased	23.02	15.18	7	59453	97	63429465
Myalgia	22.96	15.18	66	59394	146463	63283099
Fanconi syndrome	22.95	15.18	15	59445	1377	63428185
Peritonitis	22.84	15.18	50	59410	17104	63412458
Urinary tract infection bacterial	22.74	15.18	26	59434	5096	63424466
Blood glucose increased	22.67	15.18	27	59433	83729	63345833
Neck pain	22.59	15.18	19	59441	69299	63360263
Lymphangioleiomyomatosis	22.54	15.18	8	59452	184	63429378
Oesophageal stenosis	22.52	15.18	21	59439	3245	63426317
Acute myelomonocytic leukaemia	22.50	15.18	8	59452	185	63429377
Vision blurred	22.45	15.18	32	59428	91892	63337670
Cytomegalovirus infection	22.36	15.18	56	59404	20896	63408666
Odynophagia	22.10	15.18	31	59429	7455	63422107
Respiratory symptom	22.08	15.18	21	59439	3326	63426236
Blood pressure increased	21.90	15.18	78	59382	161984	63267578
Pregnancy	21.89	15.18	4	59456	36832	63392730
Streptococcal bacteraemia	21.88	15.18	16	59444	1761	63427801
Femur fracture	21.87	15.18	6	59454	41750	63387812
Female genital tract fistula	21.87	15.18	31	59429	7528	63422034
Mucosal erosion	21.78	15.18	15	59445	1501	63428061
Oroticaciduria	21.66	15.18	4	59456	3	63429559
Osteosarcoma metastatic	21.65	15.18	5	59455	21	63429541
Drug reaction with eosinophilia and systemic symptoms	21.62	15.18	3	59457	33833	63395729
Burning sensation	21.62	15.18	12	59448	54395	63375167
Failure to thrive	21.53	15.18	30	59430	7168	63422394
Median nerve injury	21.46	15.18	5	59455	22	63429540
Ovarian vein thrombosis	21.43	15.18	6	59454	61	63429501
Therapy responder	21.32	15.18	9	59451	334	63429228
Cerebral salt-wasting syndrome	21.17	15.18	6	59454	64	63429498
Maternal death affecting foetus	21.13	15.18	4	59456	4	63429558
Product quality issue	21.09	15.18	4	59456	35861	63393701
Oesophageal infection	20.80	15.18	9	59451	355	63429207
Medulloblastoma recurrent	20.76	15.18	6	59454	69	63429493
Plasma cell leukaemia	20.67	15.18	13	59447	1117	63428445
Blood magnesium decreased	20.53	15.18	41	59419	13157	63416405
Sarcomatoid carcinoma	20.46	15.18	5	59455	28	63429534
Gastric disorder	20.28	15.18	5	59455	37364	63392198
Aspergilloma	20.24	15.18	8	59452	250	63429312
Vaginitis gardnerella	20.17	15.18	5	59455	30	63429532
Joint stiffness	20.16	15.18	7	59453	41862	63387700
VIth nerve paresis	20.01	15.18	6	59454	79	63429483
Pulmonary vascular disorder	19.92	15.18	9	59451	394	63429168
Peritoneal gliomatosis	19.86	15.18	4	59456	7	63429555
Radiation mucositis	19.76	15.18	5	59455	33	63429529
Pain in jaw	19.72	15.18	8	59452	43488	63386074
Leukaemic lymphoma	19.68	15.18	6	59454	84	63429478
Bronchial fistula	19.63	15.18	5	59455	34	63429528
Superior sagittal sinus thrombosis	19.42	15.18	11	59449	780	63428782
Gastrointestinal necrosis	19.31	15.18	18	59442	2780	63426782
Dry eye	19.31	15.18	7	59453	40754	63388808
Lip swelling	19.28	15.18	3	59457	31060	63398502
Salivary gland cancer	19.22	15.18	7	59453	174	63429388
Blood sodium decreased	19.10	15.18	58	59402	24194	63405368
Lymphocele	19.09	15.18	11	59449	806	63428756
Ear infection	19.08	15.18	6	59454	38207	63391355
Granulocytopenia	19.04	15.18	25	59435	5647	63423915
Marchiafava-Bignami disease	18.90	15.18	4	59456	10	63429552
Blood creatine phosphokinase increased	18.75	15.18	3	59457	30427	63399135
Hiccups	18.66	15.18	16	59444	2215	63427347
Respiratory distress	18.66	15.18	72	59388	33879	63395683
Aortitis	18.62	15.18	12	59448	1075	63428487
Metastases to pelvis	18.58	15.18	9	59451	462	63429100
Gastroenteritis radiation	18.57	15.18	9	59451	463	63429099
Adrenocortical carcinoma	18.50	15.18	5	59455	44	63429518
Vascular compression	18.47	15.18	7	59453	195	63429367
Pelvic fluid collection	18.38	15.18	11	59449	865	63428697
Obesity	18.35	15.18	3	59457	29949	63399613
Sweat gland tumour	18.33	15.18	6	59454	107	63429455
Intentional product use issue	18.33	15.18	60	59400	127832	63301730
Hypoacusis	18.31	15.18	57	59403	24094	63405468
Therapy interrupted	18.29	15.18	4	59456	32451	63397111
Joint range of motion decreased	18.27	15.18	4	59456	32424	63397138
Confusional state	18.22	15.18	138	59322	236242	63193320
Death	18.17	15.18	469	58991	373912	63055650
Uterine atrophy	18.11	15.18	5	59455	48	63429514
Tumour associated fever	18.06	15.18	8	59452	334	63429228
Hypoglossal nerve paresis	18.03	15.18	6	59454	113	63429449
Candida infection	18.00	15.18	63	59397	28288	63401274
Urinary tract toxicity	17.92	15.18	3	59457	0	63429562
Gait inability	17.90	15.18	14	59446	52945	63376617
Transdifferentiation of neoplasm	17.89	15.18	4	59456	14	63429548
Sedation	17.82	15.18	7	59453	38802	63390760
Tachycardia	17.79	15.18	179	59281	117977	63311585
Hypoglycaemia	17.76	15.18	18	59442	60047	63369515
Purulent pericarditis	17.67	15.18	5	59455	53	63429509
Neurosensory hypoacusis	17.58	15.18	7	59453	223	63429339
Ill-defined disorder	17.56	15.18	31	59429	81724	63347838
Palpitations	17.51	15.18	51	59409	112719	63316843
Ovarian disorder	17.51	15.18	10	59450	720	63428842
Central nervous system vasculitis	17.51	15.18	11	59449	943	63428619
Refeeding syndrome	17.50	15.18	5	59455	55	63429507
Eye pain	17.48	15.18	5	59455	33849	63395713
Heart rate increased	17.43	15.18	39	59421	94199	63335363
Drug clearance increased	17.37	15.18	6	59454	127	63429435
Blood lactate dehydrogenase abnormal	17.36	15.18	8	59452	367	63429195
Central obesity	17.35	15.18	12	59448	1209	63428353
Hepatic lesion	17.34	15.18	22	59438	4803	63424759
Fungal oesophagitis	17.34	15.18	10	59450	734	63428828
Surgery	17.30	15.18	6	59454	35906	63393656
Blood pressure immeasurable	17.26	15.18	12	59448	1220	63428342
Urogenital disorder	17.26	15.18	5	59455	58	63429504
Sinus tachycardia	17.24	15.18	56	59404	24212	63405350
Deafness neurosensory	17.24	15.18	22	59438	4833	63424729
Chronic obstructive pulmonary disease	17.18	15.18	20	59440	62666	63366896
Roseolovirus test positive	17.18	15.18	5	59455	59	63429503
Cardiopulmonary failure	17.17	15.18	19	59441	3593	63425969
Liver abscess	17.13	15.18	17	59443	2837	63426725
Fluid intake reduced	17.05	15.18	19	59441	3622	63425940
Renal-limited thrombotic microangiopathy	17.03	15.18	5	59455	61	63429501
Throat irritation	16.95	15.18	7	59453	37640	63391922
Tumour thrombosis	16.92	15.18	4	59456	19	63429543
Melanosis	16.92	15.18	4	59456	19	63429543
Ureteric obstruction	16.85	15.18	14	59446	1856	63427706
Rhinorrhoea	16.84	15.18	22	59438	65555	63364007
Myasthenic syndrome	16.75	15.18	7	59453	253	63429309
Tearfulness	16.70	15.18	20	59440	4119	63425443
Metastases to pleura	16.70	15.18	13	59447	1572	63427990
Hallucination	16.70	15.18	16	59444	54801	63374761
Abdominal compartment syndrome	16.62	15.18	9	59451	584	63428978
Necrosis	16.61	15.18	23	59437	5464	63424098
Ovarian failure	16.59	15.18	12	59448	1298	63428264
Tumour invasion	16.59	15.18	6	59454	146	63429416
Necrotising colitis	16.48	15.18	9	59451	594	63428968
Low cardiac output syndrome	16.48	15.18	8	59452	413	63429149
Muscular weakness	16.45	15.18	59	59401	122294	63307268
Haemoglobin abnormal	16.42	15.18	22	59438	5066	63424496
Hypoxia	16.40	15.18	104	59356	59688	63369874
Underdose	16.27	15.18	3	59457	27453	63402109
Small cell lung cancer	16.24	15.18	13	59447	1636	63427926
Renal tubular dysfunction	16.23	15.18	8	59452	427	63429135
Skin toxicity	16.17	15.18	21	59439	4693	63424869
Staphylococcal infection	16.15	15.18	79	59381	41177	63388385
Metastases to retroperitoneum	16.15	15.18	6	59454	158	63429404
Aorto-oesophageal fistula	16.14	15.18	4	59456	24	63429538
Tracheal stenosis	16.11	15.18	6	59454	159	63429403
Metastatic neoplasm	16.10	15.18	20	59440	4275	63425287
Blood culture positive	16.09	15.18	21	59439	4714	63424848
Limb discomfort	16.08	15.18	4	59456	29712	63399850
Clostridium difficile colitis	16.02	15.18	49	59411	20520	63409042
VIth nerve disorder	15.85	15.18	3	59457	3	63429559
Stomatitis	15.81	15.18	199	59261	138526	63291036
Stent malfunction	15.78	15.18	5	59455	80	63429482
Bacterial sepsis	15.76	15.18	19	59441	3939	63425623
Pseudomonal sepsis	15.72	15.18	15	59445	2386	63427176
Blood phosphorus decreased	15.53	15.18	20	59440	4433	63425129
Neuromyopathy	15.49	15.18	9	59451	670	63428892
Metastases to the mediastinum	15.36	15.18	8	59452	480	63429082
Acute promyelocytic leukaemia	15.31	15.18	10	59450	917	63428645
Electrocardiogram ST segment depression	15.20	15.18	16	59444	2861	63426701
Drug-device interaction	15.18	15.18	5	59455	91	63429471

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1417.99	13.27	1713	84514	135136	34735568
Neutropenia	1019.04	13.27	1566	84661	155212	34715492
Disease progression	848.28	13.27	1181	85046	106896	34763808
Mucosal inflammation	763.61	13.27	685	85542	37937	34832767
Malignant neoplasm progression	602.26	13.27	902	85325	87144	34783560
Thrombocytopenia	602.23	13.27	1243	84984	155004	34715700
Myelosuppression	462.36	13.27	382	85845	18883	34851821
Pancytopenia	429.95	13.27	810	85417	94347	34776357
Bone marrow failure	376.86	13.27	411	85816	28842	34841862
Dehydration	351.56	13.27	900	85327	129069	34741635
Leukopenia	343.95	13.27	582	85645	62274	34808430
Haematotoxicity	342.50	13.27	227	86000	7967	34862737
Neoplasm progression	292.49	13.27	323	85904	22977	34847727
Stomatitis	290.78	13.27	436	85791	42078	34828626
Vomiting	281.92	13.27	1282	84945	246339	34624365
Neutropenic sepsis	267.45	13.27	242	85985	13525	34857179
Anaemia	262.50	13.27	1204	85023	232131	34638573
Acute myeloid leukaemia	249.82	13.27	265	85962	18005	34852699
Dysphagia	247.37	13.27	503	85724	61878	34808826
Therapy partial responder	246.05	13.27	198	86029	9418	34861286
Nausea	231.51	13.27	1530	84697	338378	34532326
Renal salt-wasting syndrome	230.78	13.27	68	86159	277	34870427
Drug abuse	228.57	13.27	3	86224	99093	34771611
Nephropathy toxic	228.41	13.27	213	86014	12375	34858329
Second primary malignancy	226.84	13.27	174	86053	7712	34862992
Completed suicide	226.31	13.27	3	86224	98165	34772539
Product dose omission issue	224.60	13.27	19	86208	119692	34751012
Off label use	220.78	13.27	1775	84452	417749	34452955
Neutrophil count decreased	216.89	13.27	424	85803	50680	34820024
Arthralgia	193.10	13.27	89	86138	169952	34700752
Fall	180.32	13.27	142	86085	202743	34667961
Aortic thrombosis	176.55	13.27	68	86159	710	34869994
Pulmonary embolism	169.81	13.27	547	85680	89199	34781505
Myelodysplastic syndrome	154.70	13.27	213	86014	18995	34851709
Tumour lysis syndrome	153.98	13.27	200	86027	16859	34853845
Drug interaction	144.05	13.27	209	86018	225737	34644967
Ototoxicity	142.60	13.27	77	86150	1840	34868864
Decreased appetite	139.24	13.27	791	85436	165601	34705103
Pyrexia	132.40	13.27	1327	84900	331686	34539018
Cardiotoxicity	127.16	13.27	108	86119	5540	34865164
Headache	122.59	13.27	191	86036	200444	34670260
Overdose	119.30	13.27	38	86189	91021	34779683
Hyponatraemia	118.45	13.27	460	85767	82231	34788473
Diffuse large B-cell lymphoma refractory	114.60	13.27	58	86169	1208	34869496
White blood cell count decreased	111.68	13.27	499	85728	94946	34775758
Weight increased	111.37	13.27	45	86182	92988	34777716
Diffuse large B-cell lymphoma recurrent	110.27	13.27	79	86148	3149	34867555
Acute kidney injury	107.28	13.27	1186	85041	303802	34566902
Septic shock	105.64	13.27	403	85824	71431	34799273
Anastomotic leak	104.61	13.27	44	86183	587	34870117
Hypomagnesaemia	103.39	13.27	190	86037	21661	34849043
Depression	102.32	13.27	56	86171	97042	34773662
Oesophagitis	102.21	13.27	144	86083	13117	34857587
Arterial thrombosis	102.07	13.27	57	86170	1458	34869246
Febrile bone marrow aplasia	101.58	13.27	113	86114	8096	34862608
Rhabdomyolysis	99.50	13.27	23	86204	68140	34802564
Intentional product misuse	95.23	13.27	4	86223	45607	34825097
Radiation skin injury	94.41	13.27	43	86184	702	34870002
Hospitalisation	94.18	13.27	14	86213	56888	34813816
Platelet count decreased	91.52	13.27	556	85671	119161	34751543
Anxiety	91.50	13.27	67	86160	99361	34771343
Metastases to central nervous system	91.46	13.27	107	86120	8098	34862606
Aorto-oesophageal fistula	90.90	13.27	22	86205	31	34870673
Cardiac failure congestive	90.72	13.27	46	86181	83224	34787480
Muscle spasms	90.21	13.27	36	86191	74965	34795739
Peripheral swelling	88.42	13.27	39	86188	76502	34794202
Sepsis	87.58	13.27	706	85521	165855	34704849
Hypophagia	87.26	13.27	187	86040	23835	34846869
Insomnia	85.70	13.27	78	86149	103829	34766875
Deafness	84.86	13.27	121	86106	11144	34859560
Renal impairment	84.70	13.27	458	85769	94055	34776649
Metastases to lung	83.67	13.27	109	86118	9211	34861493
Nasopharyngitis	83.47	13.27	34	86193	69934	34800770
Condition aggravated	82.51	13.27	224	86003	191972	34678732
Joint swelling	82.04	13.27	23	86204	59867	34810837
Osteoradionecrosis	80.59	13.27	22	86205	63	34870641
Inappropriate antidiuretic hormone secretion	80.35	13.27	126	86101	12627	34858077
Blood pressure increased	80.24	13.27	60	86167	88042	34782662
Gastric perforation	80.01	13.27	59	86168	2461	34868243
Suicide attempt	79.80	13.27	4	86223	39112	34831592
Suicidal ideation	79.72	13.27	5	86222	40383	34830321
Myalgia	79.59	13.27	55	86172	84055	34786649
Peripheral artery thrombosis	78.88	13.27	57	86170	2303	34868401
Odynophagia	78.86	13.27	82	86145	5439	34865265
Peripheral ischaemia	76.84	13.27	82	86145	5605	34865099
Musculoskeletal stiffness	76.07	13.27	12	86215	46668	34824036
Hypokalaemia	75.44	13.27	314	85913	57900	34812804
Inappropriate schedule of product administration	74.75	13.27	30	86197	62266	34808438
Pain in extremity	72.91	13.27	125	86102	126388	34744316
Pneumonitis	72.79	13.27	216	86011	33662	34837042
Vena cava thrombosis	71.66	13.27	42	86185	1180	34869524
Product use in unapproved indication	70.03	13.27	513	85714	116986	34753718
Tinnitus	68.96	13.27	153	86074	19965	34850739
Drug reaction with eosinophilia and systemic symptoms	68.56	13.27	3	86224	33009	34837695
Neutropenic colitis	68.49	13.27	59	86168	3085	34867619
Oesophageal fistula	67.28	13.27	26	86201	274	34870430
Asthma	67.22	13.27	12	86215	42644	34828060
Hepatitis B	66.65	13.27	78	86149	5905	34864799
Blood lactate dehydrogenase increased	65.87	13.27	163	86064	22827	34847877
Psoriasis	65.50	13.27	9	86218	38803	34831901
Deafness neurosensory	64.83	13.27	55	86172	2816	34867888
Disease recurrence	64.38	13.27	155	86072	21335	34849369
General physical health deterioration	64.29	13.27	538	85689	127731	34742973
Rheumatoid arthritis	64.22	13.27	9	86218	38229	34832475
Portal venous gas	64.07	13.27	27	86200	362	34870342
Cardiac disorder	64.04	13.27	14	86213	43112	34827592
Radiation pneumonitis	62.56	13.27	52	86175	2588	34868116
Wheezing	62.38	13.27	13	86214	41389	34829315
Renal failure	61.96	13.27	541	85686	130016	34740688
B-cell lymphoma recurrent	61.78	13.27	33	86194	771	34869933
Aplasia	61.72	13.27	66	86161	4522	34866182
Death	60.31	13.27	660	85567	397389	34473315
Splenic infarction	60.14	13.27	46	86181	2029	34868675
Neuropathy peripheral	59.99	13.27	381	85846	82882	34787822
Pruritus	59.74	13.27	167	86060	141814	34728890
Heart rate decreased	59.58	13.27	5	86222	31740	34838964
Bacterial translocation	59.33	13.27	25	86202	335	34870369
Injection site pain	59.27	13.27	12	86215	38993	34831711
Gastrointestinal toxicity	59.18	13.27	51	86176	2668	34868036
Colitis	58.95	13.27	216	86011	37534	34833170
Dermatitis	58.89	13.27	93	86134	9375	34861329
Prostate cancer	58.61	13.27	13	86214	39636	34831068
Deep vein thrombosis	58.28	13.27	316	85911	64932	34805772
Dizziness	57.84	13.27	310	85917	218211	34652493
Hiccups	57.22	13.27	95	86132	9987	34860717
Hallucination	56.74	13.27	28	86199	51470	34819234
Oesophageal stenosis	56.04	13.27	41	86186	1689	34869015
Somnolence	55.94	13.27	119	86108	110997	34759707
Aggression	55.18	13.27	14	86213	38950	34831754
Tremor	54.88	13.27	74	86153	82513	34788191
Influenza	54.73	13.27	27	86200	49639	34821065
Tumour necrosis	54.58	13.27	36	86191	1252	34869452
Gait disturbance	53.87	13.27	79	86148	85061	34785643
Metastases to liver	53.86	13.27	110	86117	13553	34857151
Vision blurred	53.73	13.27	23	86204	45940	34824764
Bacteraemia	53.56	13.27	137	86090	19580	34851124
Oesophagobronchial fistula	52.21	13.27	19	86208	167	34870537
Malignant transformation	51.89	13.27	30	86197	821	34869883
Feeling abnormal	51.48	13.27	48	86179	63187	34807517
Radiation oesophagitis	51.34	13.27	24	86203	417	34870287
Mobility decreased	50.81	13.27	7	86220	30121	34840583
Hypertension	50.62	13.27	170	86057	136273	34734431
Osteosarcoma	50.48	13.27	21	86206	272	34870432
Progressive multifocal leukoencephalopathy	50.14	13.27	88	86139	9676	34861028
Electrolyte imbalance	49.83	13.27	110	86117	14302	34856402
Arthritis	48.99	13.27	9	86218	31337	34839367
Wrong technique in product usage process	48.94	13.27	14	86213	35972	34834732
Acute respiratory distress syndrome	48.75	13.27	158	86069	25811	34844893
Blood creatine phosphokinase increased	48.50	13.27	25	86202	44832	34825872
Thrombotic microangiopathy	48.48	13.27	91	86136	10539	34860165
Incorrect dose administered	47.80	13.27	20	86207	40495	34830209
Urticaria	47.72	13.27	50	86177	62327	34808377
Blood pressure fluctuation	47.32	13.27	4	86223	25245	34845459
Memory impairment	47.05	13.27	24	86203	43294	34827410
Respiratory failure	46.94	13.27	441	85786	108131	34762573
Metastases to lymph nodes	46.71	13.27	58	86169	4670	34866034
Coronary artery disease	46.46	13.27	31	86196	48274	34822430
Pulmonary vascular disorder	46.45	13.27	26	86201	668	34870036
Ameloblastoma	46.29	13.27	15	86212	89	34870615
Hypocalcaemia	45.80	13.27	148	86079	24141	34846563
Leukoencephalopathy	45.37	13.27	54	86173	4161	34866543
Interstitial lung disease	45.33	13.27	296	85931	64986	34805718
Atypical haemolytic uraemic syndrome	45.14	13.27	20	86207	305	34870399
Abdominal discomfort	44.62	13.27	49	86178	59786	34810918
Drug hypersensitivity	44.17	13.27	82	86145	80447	34790257
Mantle cell lymphoma recurrent	44.15	13.27	26	86201	737	34869967
Carotid artery thrombosis	43.45	13.27	20	86207	335	34870369
Foetal exposure during pregnancy	43.07	13.27	20	86207	38081	34832623
Large intestine perforation	42.84	13.27	76	86151	8427	34862277
Renal tubular disorder	42.77	13.27	55	86172	4588	34866116
Neoplasm recurrence	42.61	13.27	39	86188	2210	34868494
Adverse drug reaction	42.61	13.27	10	86217	29332	34841372
Cytomegalovirus oesophagitis	42.38	13.27	22	86205	484	34870220
Embolism arterial	42.31	13.27	24	86203	633	34870071
Azoospermia	42.26	13.27	21	86206	420	34870284
Salivary gland cancer	42.23	13.27	19	86208	301	34870403
Product prescribing error	41.97	13.27	4	86223	22923	34847781
Angioedema	41.66	13.27	20	86207	37354	34833350
Hyperammonaemic encephalopathy	41.52	13.27	39	86188	2285	34868419
Intestinal ischaemia	41.00	13.27	71	86156	7723	34862981
Renal infarct	40.97	13.27	31	86196	1345	34869359
Influenza like illness	40.96	13.27	9	86218	27625	34843079
Embolism	40.77	13.27	71	86156	7758	34862946
Balance disorder	40.59	13.27	25	86202	40629	34830075
Pulmonary arteriopathy	40.28	13.27	13	86214	76	34870628
Metastasis	39.61	13.27	50	86177	4094	34866610
Hypoglycaemia	39.38	13.27	46	86181	54594	34816110
Pain	39.15	13.27	320	85907	204355	34666349
Pulmonary toxicity	39.09	13.27	61	86166	6086	34864618
Enteritis	38.76	13.27	71	86156	8071	34862633
Tumour perforation	38.60	13.27	18	86209	311	34870393
Pneumatosis intestinalis	38.56	13.27	48	86179	3875	34866829
Electrocardiogram QT prolonged	38.42	13.27	27	86200	40925	34829779
Therapeutic product effect decreased	38.10	13.27	19	86208	34724	34835980
Anastomotic complication	37.96	13.27	19	86208	386	34870318
Cataract	37.87	13.27	9	86218	26177	34844527
Bronchial fistula	37.54	13.27	15	86212	174	34870530
Nasal congestion	37.39	13.27	6	86221	23051	34847653
Blood stem cell transplant failure	37.23	13.27	19	86208	403	34870301
Unevaluable event	37	13.27	17	86210	32573	34838131
Sleep disorder	36.81	13.27	16	86211	31672	34839032
Osteoarthritis	36.75	13.27	4	86223	20638	34850066
Confusional state	36.72	13.27	207	86020	143953	34726751
Rash	36.60	13.27	362	85865	222390	34648314
Myocardial infarction	36.47	13.27	164	86063	120921	34749783
Depressed mood	36.36	13.27	3	86224	19314	34851390
International normalised ratio increased	36.13	13.27	38	86189	47289	34823415
Chest discomfort	36.07	13.27	49	86178	54481	34816223
Lymphopenia	35.89	13.27	105	86122	16230	34854474
Back pain	35.46	13.27	167	86060	121622	34749082
Chronic obstructive pulmonary disease	35.44	13.27	41	86186	48877	34821827
Contusion	35.42	13.27	23	86204	36341	34834363
Toxicity to various agents	35.31	13.27	320	85907	200042	34670662
Bradycardia	35.30	13.27	84	86143	75334	34795370
Radiation mucositis	35.27	13.27	15	86212	206	34870498
Chemotherapy	35.27	13.27	21	86206	608	34870096
Blood sodium decreased	35.26	13.27	104	86123	16147	34854557
Cytopenia	35.17	13.27	89	86138	12634	34858070
Tracheo-oesophageal fistula	35.15	13.27	19	86208	455	34870249
Sedation	35.14	13.27	5	86222	21001	34849703
Neurosensory hypoacusis	35.05	13.27	7	86220	0	34870704
Teratoma	34.90	13.27	9	86218	19	34870685
Lymphadenopathy	34.88	13.27	151	86076	28312	34842392
Blood glucose increased	34.78	13.27	70	86157	66648	34804056
Recall phenomenon	34.48	13.27	20	86207	551	34870153
Cystitis haemorrhagic	34.24	13.27	55	86172	5624	34865080
Tumour haemorrhage	33.63	13.27	39	86188	2923	34867781
Alopecia	33.61	13.27	134	86093	24221	34846483
Blood creatinine increased	33.48	13.27	370	85857	94606	34776098
Chloroma	33.30	13.27	19	86208	507	34870197
Neurotoxicity	33.28	13.27	109	86118	17901	34852803
Acquired gene mutation	32.75	13.27	27	86200	1328	34869376
Serotonin syndrome	32.75	13.27	5	86222	19928	34850776
Nephrolithiasis	32.65	13.27	17	86210	30316	34840388
Empyema	32.46	13.27	40	86187	3196	34867508
Blood cholesterol increased	31.88	13.27	6	86221	20537	34850167
Sinusitis	31.87	13.27	33	86194	41369	34829335
Dyskinesia	31.83	13.27	8	86219	22405	34848299
Malaise	31.78	13.27	299	85928	185526	34685178
Bicytopenia	31.55	13.27	34	86193	2350	34868354
Hypoacusis	31.34	13.27	100	86127	16201	34854503
Gout	31.25	13.27	5	86222	19248	34851456
Hepatitis B reactivation	31.09	13.27	43	86184	3848	34866856
Pancreatitis	31.08	13.27	30	86197	38861	34831843
Blood pressure systolic increased	31.08	13.27	9	86218	22943	34847761
Blood HIV RNA increased	30.76	13.27	25	86202	1205	34869499
Radiation injury	30.58	13.27	18	86209	510	34870194
Immune-mediated hepatic disorder	30.35	13.27	23	86204	1000	34869704
Injury	30.13	13.27	7	86220	20680	34850024
Lymphoma	30.01	13.27	83	86144	12424	34858280
Localised infection	29.86	13.27	4	86223	17583	34853121
Osteosarcoma recurrent	29.81	13.27	8	86219	21	34870683
Loss of personal independence in daily activities	29.67	13.27	23	86204	33156	34837548
Palmar-plantar erythrodysaesthesia syndrome	29.57	13.27	100	86127	16695	34854009
Diarrhoea	29.48	13.27	1208	85019	388704	34482000
Pharyngeal inflammation	29.23	13.27	15	86212	322	34870382
Drug resistance	29.10	13.27	134	86093	25793	34844911
Papillary thyroid cancer	29.08	13.27	19	86208	650	34870054
Flagellate dermatitis	28.97	13.27	10	86217	74	34870630
Arterial occlusive disease	28.95	13.27	44	86183	4290	34866414
Oedema peripheral	28.92	13.27	175	86052	119637	34751067
Gait inability	28.36	13.27	8	86219	20750	34849954
Gastrooesophageal reflux disease	28.33	13.27	31	86196	37893	34832811
Diabetes mellitus	28.19	13.27	45	86182	46828	34823876
Hepatic candidiasis	28.12	13.27	9	86218	51	34870653
Spinal column injury	27.81	13.27	18	86209	606	34870098
Haematochezia	27.68	13.27	45	86182	46489	34824215
Lactic acidosis	27.58	13.27	27	86200	34745	34835959
Peritonitis	27.55	13.27	96	86131	16269	34854435
Liver function test abnormal	27.21	13.27	22	86205	31052	34839652
Oesophageal perforation	27.14	13.27	23	86204	1176	34869528
Product administration error	27.08	13.27	4	86223	16340	34854364
Blindness cortical	27.06	13.27	15	86212	378	34870326
Hyperhidrosis	26.90	13.27	96	86131	75596	34795108
Abnormal behaviour	26.86	13.27	14	86213	24955	34845749
Abdominal neoplasm	26.78	13.27	15	86212	386	34870318
Primitive neuroectodermal tumour	26.63	13.27	9	86218	62	34870642
Emotional distress	26.53	13.27	3	86224	15023	34855681
Arteriospasm coronary	26.46	13.27	37	86190	3345	34867359
Thrombophlebitis	26.34	13.27	36	86191	3186	34867518
Labelled drug-drug interaction medication error	26.33	13.27	3	86224	14936	34855768
Wound	26.16	13.27	3	86224	14861	34855843
Swelling	26.11	13.27	40	86187	42326	34828378
Upper respiratory tract infection	25.84	13.27	26	86201	33033	34837671
Diaphragm muscle weakness	25.74	13.27	11	86216	153	34870551
Sleep apnoea syndrome	25.68	13.27	9	86218	20312	34850392
Disseminated intravascular coagulation	25.41	13.27	114	86113	21702	34849002
Road traffic accident	25.23	13.27	6	86221	17444	34853260
Cerebral infarction	25.19	13.27	134	86093	27321	34843383
Lymphadenopathy mediastinal	25.10	13.27	31	86196	2482	34868222
Extravasation	25.09	13.27	27	86200	1863	34868841
Irritability	24.90	13.27	15	86212	24675	34846029
Visual impairment	24.88	13.27	31	86196	35771	34834933
Transient ischaemic attack	24.87	13.27	19	86208	27594	34843110
Fluid retention	24.86	13.27	18	86209	26869	34843835
Hot flush	24.61	13.27	7	86220	18059	34852645
Dermatitis acneiform	24.59	13.27	50	86177	6139	34864565
Agitation	24.49	13.27	67	86160	57332	34813372
Refeeding syndrome	24.48	13.27	7	86220	25	34870679
Psychotic disorder	24.45	13.27	15	86212	24437	34846267
Superior mesenteric artery syndrome	24.35	13.27	9	86218	83	34870621
Therapy cessation	24.22	13.27	6	86221	16967	34853737
Testicular malignant teratoma	24.18	13.27	6	86221	10	34870694
Enterocolitis	24.15	13.27	58	86169	7968	34862736
Angina pectoris	24.14	13.27	25	86202	31338	34839366
Cholelithiasis	24.05	13.27	11	86216	21137	34849567
Oral candidiasis	23.93	13.27	75	86152	12035	34858669
Cerebral ischaemia	23.86	13.27	50	86177	6272	34864432
Peripheral sensory neuropathy	23.82	13.27	52	86175	6708	34863996
Herpes zoster	23.68	13.27	30	86197	34369	34836335
Accidental overdose	23.66	13.27	10	86217	20130	34850574
Muscular weakness	23.61	13.27	96	86131	72801	34797903
Myoclonus	23.50	13.27	4	86223	14721	34855983
Granulocyte count decreased	23.47	13.27	18	86209	797	34869907
Disturbance in attention	23.18	13.27	18	86209	25927	34844777
Immune-mediated dermatitis	23.15	13.27	13	86214	336	34870368
Illness	23.15	13.27	3	86224	13526	34857178
Drug intolerance	22.90	13.27	73	86154	59497	34811207
Refractory cancer	22.90	13.27	10	86217	147	34870557
Retinal toxicity	22.89	13.27	14	86213	426	34870278
Medulloblastoma recurrent	22.64	13.27	8	86219	64	34870640
Cerebral venous sinus thrombosis	22.63	13.27	15	86212	526	34870178
Adenoviral hepatitis	22.55	13.27	15	86212	529	34870175
Cerebral venous thrombosis	22.48	13.27	17	86210	737	34869967
Deafness bilateral	22.45	13.27	20	86207	1094	34869610
BK virus infection	22.38	13.27	46	86181	5692	34865012
Paraneoplastic syndrome	22.33	13.27	15	86212	538	34870166
Performance status decreased	22.17	13.27	38	86189	4099	34866605
COVID-19	22.17	13.27	107	86120	77443	34793261
Granulocyte-colony stimulating factor level increased	22.11	13.27	5	86222	4	34870700
Bronchitis	21.89	13.27	44	86183	41919	34828785
EGFR gene mutation	21.75	13.27	10	86217	167	34870537
Meningitis tuberculous	21.66	13.27	16	86211	669	34870035
Pleural effusion	21.53	13.27	301	85926	81245	34789459
Accidental exposure to product	21.52	13.27	3	86224	12799	34857905
Frequent bowel movements	21.49	13.27	3	86224	12784	34857920
Speech disorder	21.49	13.27	19	86208	25667	34845037
Underdose	21.44	13.27	4	86223	13776	34856928
Necrosis	21.29	13.27	45	86182	5678	34865026
Full blood count decreased	21.22	13.27	9	86218	18079	34852625
Procedural nausea	21.16	13.27	8	86219	79	34870625
Palpitations	20.79	13.27	42	86185	39944	34830760
Choriocarcinoma	20.68	13.27	5	86222	7	34870697
Coronary artery thrombosis	20.55	13.27	26	86201	2133	34868571
Metastases to peritoneum	20.47	13.27	24	86203	1820	34868884
Soft tissue disorder	20.37	13.27	16	86211	734	34869970
Loss of consciousness	20.33	13.27	120	86107	82547	34788157
Morphoea	20.31	13.27	10	86217	196	34870508
Gene mutation	20.26	13.27	21	86206	1387	34869317
Blood glucose decreased	20.26	13.27	4	86223	13233	34857471
Burning sensation	20.26	13.27	10	86217	18384	34852320
Hypochloraemia	20.25	13.27	15	86212	630	34870074
Poisoning	20.24	13.27	3	86224	12223	34858481
Acquired tracheo-oesophageal fistula	20.24	13.27	8	86219	90	34870614
Hypogammaglobulinaemia	20.21	13.27	53	86174	7687	34863017
Hepatic steatosis	20.19	13.27	10	86217	18352	34852352
Erectile dysfunction	20.17	13.27	13	86214	20624	34850080
Injection site erythema	20.16	13.27	7	86220	15892	34854812
Pneumonia escherichia	20.10	13.27	13	86214	437	34870267
Eosinophilia	20.07	13.27	21	86206	26201	34844503
Metastases to skin	20.05	13.27	13	86214	439	34870265
Mitral valve incompetence	19.97	13.27	6	86221	14937	34855767
Metastases to bone	19.96	13.27	70	86157	11900	34858804
Gastrointestinal obstruction	19.88	13.27	17	86210	880	34869824
Hypoaesthesia	19.84	13.27	81	86146	61363	34809341
Polyneuropathy	19.78	13.27	81	86146	14815	34855889
Vascular injury	19.74	13.27	11	86216	280	34870424
Arteritis	19.74	13.27	12	86215	361	34870343
Candida pneumonia	19.71	13.27	13	86214	452	34870252
Necrosis ischaemic	19.71	13.27	11	86216	281	34870423
Adrenocortical carcinoma	19.71	13.27	6	86221	28	34870676
Metastases to meninges	19.70	13.27	21	86206	1433	34869271
Gastrointestinal ischaemia	19.68	13.27	10	86217	210	34870494
Neuroblastoma recurrent	19.65	13.27	9	86218	149	34870555
Pneumonia adenoviral	19.62	13.27	12	86215	365	34870339
Hallucination, auditory	19.55	13.27	3	86224	11914	34858790
Campylobacter test positive	19.53	13.27	6	86221	29	34870675
Obesity	19.48	13.27	4	86223	12874	34857830
Pneumothorax	19.48	13.27	96	86131	18996	34851708
Swelling face	19.44	13.27	17	86210	23088	34847616
Dementia	19.35	13.27	5	86222	13743	34856961
Tumour thrombosis	19.34	13.27	8	86219	102	34870602
Procedural vomiting	19.30	13.27	10	86217	219	34870485
Transitional cell carcinoma recurrent	19.25	13.27	5	86222	11	34870693
Peritoneal lesion	19.20	13.27	8	86219	104	34870600
Respiratory depression	19.19	13.27	8	86219	16237	34854467
Carotid artery dissection	19.17	13.27	9	86218	158	34870546
Product quality issue	19.16	13.27	9	86218	17026	34853678
Plasma cell leukaemia	19.13	13.27	17	86210	927	34869777
Delusion	18.96	13.27	4	86223	12631	34858073
Iliac artery occlusion	18.87	13.27	9	86218	164	34870540
Treatment noncompliance	18.83	13.27	25	86202	28075	34842629
Hepatic enzyme increased	18.70	13.27	43	86184	39037	34831667
Injection site swelling	18.69	13.27	3	86224	11524	34859180
Oesophageal pain	18.63	13.27	16	86211	833	34869871
Withdrawal syndrome	18.57	13.27	4	86223	12451	34858253
Traumatic lung injury	18.51	13.27	19	86208	1241	34869463
Migraine	18.51	13.27	10	86217	17468	34853236
Thrombocytosis	18.50	13.27	35	86192	4077	34866627
Fanconi syndrome	18.45	13.27	22	86205	1698	34869006
B-cell lymphoma refractory	18.39	13.27	9	86218	174	34870530
Laryngeal pain	18.38	13.27	28	86199	2736	34867968
Neutrophil count abnormal	18.26	13.27	23	86204	1879	34868825
Skin toxicity	18.24	13.27	38	86189	4746	34865958
Visceral venous thrombosis	18.14	13.27	5	86222	15	34870689
Movement disorder	18.13	13.27	4	86223	12244	34858460
Neoplasm	18.08	13.27	41	86186	5426	34865278
Mucosal toxicity	18.07	13.27	10	86217	251	34870453
Dry skin	17.91	13.27	31	86196	31256	34839448
Transformation to acute myeloid leukaemia	17.83	13.27	15	86212	759	34869945
Paranoia	17.74	13.27	4	86223	12064	34858640
Bladder cancer	17.70	13.27	9	86218	16269	34854435
Venous thrombosis	17.69	13.27	31	86196	3404	34867300
Failure to thrive	17.67	13.27	54	86173	8547	34862157
Urinary tract infection	17.66	13.27	128	86099	83953	34786751
Intestinal infarction	17.63	13.27	13	86214	542	34870162
Hypoalbuminaemia	17.62	13.27	68	86159	12106	34858598
Extremity necrosis	17.60	13.27	23	86204	1949	34868755
Gastrointestinal perforation	17.52	13.27	33	86194	3830	34866874
Cardiogenic shock	17.51	13.27	24	86203	26594	34844110
White blood cell disorder	17.50	13.27	21	86206	1632	34869072
Osteomyelitis	17.43	13.27	9	86218	16127	34854577
Chromaturia	17.39	13.27	7	86220	14513	34856191
Metastases to chest wall	17.34	13.27	9	86218	198	34870506
Trigeminal nerve paresis	17.27	13.27	4	86223	4	34870700
Joint stiffness	17.25	13.27	3	86224	10870	34859834
Hypophosphataemia	17.13	13.27	63	86164	10963	34859741
Blood creatinine	17.09	13.27	6	86221	47	34870657
Infected neoplasm	17.09	13.27	7	86220	87	34870617
Human chorionic gonadotropin increased	17.04	13.27	5	86222	20	34870684
Head injury	17.00	13.27	12	86215	18148	34852556
Dermatitis diaper	16.97	13.27	10	86217	284	34870420
Eye pain	16.95	13.27	6	86221	13456	34857248
Chemotherapeutic drug level increased	16.90	13.27	9	86218	209	34870495
Cell-mediated immune deficiency	16.87	13.27	6	86221	49	34870655
Laryngeal inflammation	16.85	13.27	5	86222	21	34870683
Haemorrhagic tumour necrosis	16.80	13.27	4	86223	5	34870699
Blister	16.72	13.27	19	86208	22839	34847865
Immune-mediated renal disorder	16.71	13.27	8	86219	147	34870557
Blood triglycerides increased	16.68	13.27	7	86220	14152	34856552
Small cell lung cancer	16.66	13.27	22	86205	1883	34868821
Dyspnoea	16.64	13.27	760	85467	376022	34494682
Gingivitis ulcerative	16.56	13.27	6	86221	52	34870652
Hypersomnia	16.55	13.27	5	86222	12402	34858302
Haemoptysis	16.53	13.27	145	86082	34861	34835843
Hyperglycaemic hyperosmolar nonketotic syndrome	16.49	13.27	18	86209	1262	34869442
Muscle rigidity	16.48	13.27	3	86224	10515	34860189
Amnesia	16.44	13.27	25	86202	26538	34844166
Dysstasia	16.11	13.27	5	86222	12190	34858514
Subdural haematoma	16.03	13.27	16	86211	20405	34850299
Dyspnoea exertional	15.97	13.27	54	86173	43225	34827479
Brachiocephalic vein thrombosis	15.96	13.27	7	86220	104	34870600
Myeloid leukaemia	15.95	13.27	11	86216	412	34870292
Drug clearance decreased	15.91	13.27	21	86206	1797	34868907
Basal cell carcinoma	15.90	13.27	15	86212	19643	34851061
Ureteric dilatation	15.88	13.27	8	86219	165	34870539
Premature baby	15.85	13.27	15	86212	19618	34851086
Urine sodium increased	15.81	13.27	6	86221	60	34870644
Testicular germ cell cancer metastatic	15.81	13.27	6	86221	60	34870644
Wound evisceration	15.78	13.27	7	86220	107	34870597
Cellulitis	15.75	13.27	72	86155	52879	34817825
Subcutaneous emphysema	15.75	13.27	17	86210	1177	34869527
Rectal haemorrhage	15.70	13.27	49	86178	40200	34830504
Ill-defined disorder	15.69	13.27	72	86155	13837	34856867
Ganglioneuroma	15.66	13.27	4	86223	8	34870696
Rib fracture	15.60	13.27	8	86219	14392	34856312
Aortitis	15.56	13.27	11	86216	429	34870275
Hip fracture	15.56	13.27	5	86222	11920	34858784
Gastrointestinal anastomotic leak	15.47	13.27	11	86216	433	34870271
Staphylococcus test positive	15.44	13.27	28	86199	3158	34867546
Lymphangiosis carcinomatosa	15.43	13.27	15	86212	917	34869787
Monocyte count decreased	15.38	13.27	17	86210	1209	34869495
Osteosarcoma metastatic	15.34	13.27	4	86223	9	34870695
Seizure	15.32	13.27	175	86052	104682	34766022
Recurrent cancer	15.31	13.27	18	86209	1369	34869335
Candida infection	15.26	13.27	85	86142	17630	34853074
Tooth disorder	15.23	13.27	4	86223	10878	34859826
Anaplastic lymphoma kinase gene mutation	15.11	13.27	7	86220	119	34870585
Evans syndrome	15.10	13.27	9	86218	261	34870443
Limb injury	15.08	13.27	5	86222	11684	34859020
Salivary gland cancer recurrent	15.02	13.27	3	86224	0	34870704
Pharyngeal stenosis	15.02	13.27	3	86224	0	34870704
Heart rate increased	15.02	13.27	61	86166	46282	34824422
Chronic hepatitis B	14.98	13.27	5	86222	33	34870671
Immune-mediated lung disease	14.89	13.27	19	86208	1572	34869132
Device issue	14.87	13.27	3	86224	9774	34860930
Laboratory test abnormal	14.86	13.27	17	86210	20374	34850330
Testicular cancer metastatic	14.83	13.27	6	86221	72	34870632
Blastic plasmacytoid dendritic cell neoplasia	14.76	13.27	6	86221	73	34870631
No adverse event	14.76	13.27	21	86206	22906	34847798
Agranulocytosis	14.73	13.27	105	86122	23716	34846988
Malassezia infection	14.73	13.27	5	86222	35	34870669
Myelitis transverse	14.63	13.27	16	86211	1124	34869580
Hypovolaemia	14.54	13.27	53	86174	9181	34861523
Pulmonary oedema	14.51	13.27	64	86163	47465	34823239
Metapneumovirus bronchiolitis	14.51	13.27	4	86223	12	34870692
Haemorrhoids	14.49	13.27	9	86218	14566	34856138
Dysphonia	14.48	13.27	22	86205	23361	34847343
Abdominal pain upper	14.45	13.27	110	86117	71380	34799324
Hyperlipidaemia	14.41	13.27	9	86218	14520	34856184
Benign prostatic hyperplasia	14.34	13.27	9	86218	14486	34856218
Thrombotic thrombocytopenic purpura	14.32	13.27	28	86199	3342	34867362
Hypercreatininaemia	14.28	13.27	11	86216	490	34870214
Cough	14.15	13.27	273	85954	149867	34720837
Haematoma	14.09	13.27	26	86201	25579	34845125
Heart rate irregular	14.08	13.27	11	86216	15796	34854908
Ventricular extrasystoles	14.04	13.27	6	86221	12002	34858702
Apparent mineralocorticoid excess	14.04	13.27	5	86222	41	34870663
Renal tubular necrosis	14.02	13.27	76	86151	15604	34855100
Subclavian vein thrombosis	13.99	13.27	14	86213	887	34869817
Nocturia	13.83	13.27	4	86223	10206	34860498
Dropped head syndrome	13.82	13.27	7	86220	146	34870558
Cerebrovascular accident	13.82	13.27	138	86089	84673	34786031
Cholangitis	13.79	13.27	50	86177	8639	34862065
Sarcoma	13.75	13.27	10	86217	408	34870296
Ventricular tachycardia	13.75	13.27	28	86199	26551	34844153
Therapeutic embolisation	13.67	13.27	9	86218	312	34870392
Torulopsis infection	13.63	13.27	4	86223	16	34870688
Escherichia bacteraemia	13.63	13.27	27	86200	3253	34867451
Penile vein thrombosis	13.63	13.27	4	86223	16	34870688
Malocclusion	13.63	13.27	6	86221	90	34870614
Discomfort	13.58	13.27	16	86211	18922	34851782
Red blood cell sedimentation rate increased	13.54	13.27	3	86224	9159	34861545
Chondrosarcoma	13.54	13.27	5	86222	46	34870658
Melanosis	13.44	13.27	4	86223	17	34870687
Focal nodular hyperplasia	13.40	13.27	7	86220	156	34870548
Systemic toxicity	13.35	13.27	5	86222	48	34870656
Immunosuppression	13.35	13.27	40	86187	6264	34864440
Lip swelling	13.32	13.27	12	86215	16068	34854636

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	2362.74	12.74	2333	124465	228666	79388924
Neutropenia	1941.01	12.74	2334	124464	285376	79332214
Disease progression	1406.73	12.74	1595	125203	182767	79434823
Thrombocytopenia	1369.03	12.74	1886	124912	263373	79354217
Malignant neoplasm progression	1256.39	12.74	1302	125496	134688	79482902
Mucosal inflammation	1155.74	12.74	959	125839	74621	79542969
Pancytopenia	898.26	12.74	1208	125590	164537	79453053
Bone marrow failure	836.65	12.74	675	126123	50432	79567158
Myelosuppression	834.37	12.74	612	126186	39684	79577906
Haematotoxicity	781.59	12.74	415	126383	15104	79602486
Anaemia	665.18	12.74	1875	124923	443140	79174450
Leukopenia	574.73	12.74	812	125986	115701	79501889
Acute myeloid leukaemia	539.68	12.74	424	126374	30461	79587129
Arthralgia	515.28	12.74	137	126661	571666	79045924
Dehydration	490.95	12.74	1163	125635	247024	79370566
Vomiting	454.64	12.74	2175	124623	663653	78953937
Second primary malignancy	450.14	12.74	282	126516	14068	79603522
Renal salt-wasting syndrome	416.94	12.74	115	126683	601	79616989
Off label use	394.06	12.74	2624	124174	904591	78712999
Neutrophil count decreased	392.78	12.74	606	126192	93353	79524237
Completed suicide	373.77	12.74	3	126795	245764	79371826
Neoplasm progression	369.25	12.74	433	126365	51249	79566341
Therapy partial responder	350.44	12.74	260	126538	17137	79600453
Ototoxicity	349.36	12.74	147	126651	3127	79614463
Neutropenic sepsis	345.44	12.74	310	126488	26754	79590836
Nausea	341.00	12.74	2640	124158	954556	78663034
Nephropathy toxic	334.60	12.74	270	126528	20149	79597441
Aortic thrombosis	330.70	12.74	118	126680	1577	79616013
Joint swelling	324.51	12.74	39	126759	288607	79328983
Fall	318.11	12.74	191	126607	487438	79130152
Myelodysplastic syndrome	295.25	12.74	299	126499	30002	79587588
Product dose omission issue	286.90	12.74	30	126768	247507	79370083
Rheumatoid arthritis	283.42	12.74	11	126787	208459	79409131
Acute kidney injury	280.38	12.74	1591	125207	517813	79099777
Hypomagnesaemia	280.01	12.74	359	126439	46552	79571038
Tumour lysis syndrome	266.36	12.74	254	126544	23685	79593905
Pulmonary embolism	258.00	12.74	726	126072	170928	79446662
Pain	251.85	12.74	460	126338	703342	78914248
Peripheral swelling	241.61	12.74	65	126733	269552	79348038
Arthropathy	238.53	12.74	10	126788	177101	79440489
Drug abuse	238.27	12.74	4	126794	162687	79454903
Headache	236.80	12.74	424	126374	653348	78964242
Pyrexia	233.04	12.74	1858	124940	676851	78940739
Platelet count decreased	232.12	12.74	759	126039	193905	79423685
Sepsis	230.48	12.74	943	125855	268485	79349105
Diffuse large B-cell lymphoma recurrent	230.29	12.74	119	126679	4088	79613502
Weight increased	223.30	12.74	81	126717	277305	79340285
Musculoskeletal stiffness	222.70	12.74	14	126784	174994	79442596
Metastases to central nervous system	217.76	12.74	192	126606	16183	79601407
Cardiotoxicity	215.84	12.74	169	126629	12070	79605520
Dysphagia	215.18	12.74	548	126250	121588	79496002
Nasopharyngitis	213.24	12.74	69	126729	253812	79363778
Hypokalaemia	206.45	12.74	599	126199	143441	79474149
Abdominal discomfort	203.87	12.74	72	126726	250655	79366935
Metastases to lung	202.60	12.74	193	126605	17970	79599620
Deafness	200.22	12.74	205	126593	20832	79596758
Decreased appetite	193.06	12.74	1062	125736	341356	79276234
Drug hypersensitivity	189.24	12.74	121	126677	298795	79318795
Septic shock	188.96	12.74	524	126274	122277	79495313
Hyponatraemia	188.72	12.74	667	126131	177181	79440409
Therapeutic product effect decreased	186.89	12.74	21	126777	163842	79453748
White blood cell count decreased	186.11	12.74	690	126108	187598	79429992
Posterior reversible encephalopathy syndrome	185.68	12.74	219	126579	26062	79591528
Pain in extremity	185.12	12.74	184	126614	364354	79253236
Renal impairment	184.25	12.74	611	126187	157172	79460418
Anastomotic leak	177.46	12.74	66	126732	999	79616591
Oesophagitis	174.25	12.74	204	126594	24085	79593505
Systemic lupus erythematosus	173.28	12.74	4	126794	121145	79496445
Swelling	168.17	12.74	67	126731	216644	79400946
Neuropathy peripheral	165.69	12.74	548	126250	140757	79476833
Condition aggravated	162.99	12.74	346	126452	500778	79116812
Renal failure	162.79	12.74	692	126106	200276	79417314
Product use in unapproved indication	156.38	12.74	799	125999	249560	79368030
Stomatitis	155.30	12.74	550	126248	146207	79471383
Drug resistance	153.96	12.74	256	126542	41957	79575633
Overdose	152.98	12.74	51	126747	184155	79433435
Asthma	152.33	12.74	18	126780	135077	79482513
Insomnia	151.41	12.74	102	126696	245068	79372522
Glossodynia	149.41	12.74	3	126795	103334	79514256
Pruritus	148.93	12.74	249	126549	394399	79223191
Contraindicated product administered	146.79	12.74	35	126763	157503	79460087
Radiation skin injury	145.07	12.74	62	126736	1372	79616218
Injection site pain	144.68	12.74	18	126780	129820	79487770
Contusion	140.71	12.74	32	126766	148744	79468846
Wound	140.04	12.74	12	126786	116167	79501423
Pemphigus	139.72	12.74	4	126794	99578	79518012
Metastases to liver	137.43	12.74	196	126602	28118	79589472
Muscle spasms	137.22	12.74	53	126745	174677	79442913
Tinnitus	137.11	12.74	250	126548	44083	79573507
Oesophageal fistula	136.17	12.74	44	126754	425	79617165
Arthritis	135.42	12.74	13	126785	114867	79502723
Inappropriate antidiuretic hormone secretion	134.91	12.74	187	126611	26126	79591464
Diffuse large B-cell lymphoma refractory	131.95	12.74	58	126740	1377	79616213
Disease recurrence	131.71	12.74	245	126553	43864	79573726
Teratoma	131.05	12.74	34	126764	134	79617456
Febrile bone marrow aplasia	129.60	12.74	130	126668	12890	79604700
Sinusitis	129.44	12.74	75	126723	195426	79422164
Hypocalcaemia	127.98	12.74	260	126538	49664	79567926
Intentional product misuse	126.04	12.74	6	126792	95159	79522431
Peripheral artery thrombosis	125.99	12.74	75	126723	3408	79614182
Gastrointestinal toxicity	123.96	12.74	103	126695	8006	79609584
Depression	122.44	12.74	99	126699	216691	79400899
Deep vein thrombosis	119.28	12.74	443	126355	120476	79497114
Metastases to lymph nodes	118.85	12.74	112	126686	10285	79607305
Mobility decreased	118.12	12.74	25	126773	122150	79495440
Hypophagia	117.16	12.74	237	126561	45130	79572460
Neurotoxicity	114.31	12.74	194	126604	32324	79585266
Anxiety	113.29	12.74	137	126661	248375	79369215
Blister	112.37	12.74	26	126772	119450	79498140
Aorto-oesophageal fistula	111.81	12.74	26	126772	56	79617534
Osteoarthritis	110.98	12.74	7	126791	87302	79530288
Gastric perforation	108.49	12.74	72	126726	3965	79613625
Migraine	108.34	12.74	8	126790	87485	79530105
Ovarian germ cell teratoma	107.78	12.74	25	126773	53	79617537
Drug intolerance	106.80	12.74	159	126639	263960	79353630
Wheezing	106.57	12.74	27	126771	116637	79500953
Urticaria	106.55	12.74	83	126715	185118	79432472
Hepatic enzyme increased	106.12	12.74	81	126717	182529	79435061
Psoriasis	105.95	12.74	10	126788	89577	79528013
Pneumonitis	104.96	12.74	271	126527	60589	79557001
Palmar-plantar erythrodysaesthesia syndrome	102.64	12.74	187	126611	32947	79584643
Peripheral ischaemia	102.64	12.74	99	126699	9358	79608232
Renal tubular disorder	102.52	12.74	84	126714	6402	79611188
Dizziness	102.24	12.74	460	126338	525981	79091609
Discomfort	102.16	12.74	36	126762	125581	79492009
Venoocclusive liver disease	101.80	12.74	109	126689	11662	79605928
Electrolyte imbalance	101.70	12.74	179	126619	30702	79586888
Gait disturbance	101.53	12.74	108	126690	207398	79410192
Rash	101.51	12.74	524	126274	577834	79039756
Leukoencephalopathy	101.50	12.74	91	126707	7838	79609752
Arterial thrombosis	100.45	12.74	59	126739	2615	79614975
Hiccups	97.72	12.74	99	126699	9932	79607658
Suicidal ideation	97.39	12.74	6	126792	76334	79541256
Blood pressure increased	96.87	12.74	116	126682	211244	79406346
Bacteraemia	93.87	12.74	179	126619	32645	79584945
Stress	93.85	12.74	9	126789	79603	79537987
Hospitalisation	93.76	12.74	18	126780	94218	79523372
Radiation pneumonitis	93.45	12.74	65	126733	3868	79613722
Osteoradionecrosis	92.83	12.74	24	126774	93	79617497
Odynophagia	91.18	12.74	101	126697	11226	79606364
Dermatitis	91.08	12.74	139	126659	21182	79596408
Injury	90.72	12.74	9	126789	77487	79540103
Nasal congestion	89.33	12.74	9	126789	76543	79541047
Malignant transformation	89.16	12.74	42	126756	1176	79616414
Fibromyalgia	88.76	12.74	3	126795	64337	79553253
Feeling abnormal	88.25	12.74	74	126724	159125	79458465
Loss of personal independence in daily activities	87.62	12.74	27	126771	102553	79515037
Inappropriate schedule of product administration	87.38	12.74	52	126746	133576	79484014
Myalgia	87.09	12.74	100	126698	185541	79432049
Bronchitis	86.62	12.74	50	126748	130594	79486996
Suicide attempt	86.52	12.74	14	126784	82918	79534672
Infusion related reaction	86.07	12.74	146	126652	230091	79387499
Hypoacusis	85.70	12.74	164	126634	29986	79587604
Drug interaction	84.68	12.74	356	126442	414827	79202763
Colitis	82.05	12.74	280	126518	73027	79544563
Blood creatinine increased	81.93	12.74	473	126325	154584	79463006
Blood cholesterol increased	81.19	12.74	17	126781	83703	79533887
Teratoma benign	81.04	12.74	20	126778	61	79617529
Somnolence	80.92	12.74	161	126637	238820	79378770
Urogenital fistula	80.02	12.74	23	126775	143	79617447
Large intestine perforation	79.93	12.74	107	126691	14460	79603130
Acute respiratory distress syndrome	79.90	12.74	200	126598	43867	79573723
Blood lactate dehydrogenase increased	79.84	12.74	186	126612	38984	79578606
Recall phenomenon	79.54	12.74	38	126760	1099	79616491
Osteosarcoma	79.45	12.74	28	126770	360	79617230
Balance disorder	79.24	12.74	29	126769	98828	79518762
Drug reaction with eosinophilia and systemic symptoms	79.18	12.74	6	126792	64238	79553352
Injection site erythema	77.66	12.74	15	126783	78182	79539408
Radiation oesophagitis	76.99	12.74	32	126766	659	79616931
Metastasis	76.51	12.74	73	126725	6807	79610783
Respiratory failure	75.74	12.74	520	126278	180391	79437199
Metastases to skin	75.04	12.74	42	126756	1697	79615893
Thrombotic microangiopathy	74.45	12.74	123	126675	20046	79597544
Influenza	73.37	12.74	59	126739	129547	79488043
Blood pressure fluctuation	73.12	12.74	10	126788	67135	79550455
Bicytopenia	72.80	12.74	60	126738	4610	79612980
Cystitis haemorrhagic	72.48	12.74	81	126717	9091	79608499
Enteritis	72.31	12.74	102	126696	14481	79603109
Deafness bilateral	71.19	12.74	44	126754	2141	79615449
Exposure during pregnancy	70.99	12.74	36	126762	101096	79516494
Pleural effusion	70.88	12.74	434	126364	144828	79472762
Cytomegalovirus oesophagitis	70.80	12.74	31	126767	729	79616861
Rhabdomyolysis	70.48	12.74	38	126760	103093	79514497
Portal venous gas	70.37	12.74	26	126772	386	79617204
Neutropenic colitis	70.11	12.74	64	126734	5643	79611947
Wrong technique in product usage process	69.61	12.74	16	126782	73859	79543731
Deafness neurosensory	68.88	12.74	69	126729	6829	79610761
Memory impairment	68.23	12.74	47	126751	111687	79505903
Oesophageal stenosis	68	12.74	56	126742	4298	79613292
Chloroma	67.19	12.74	30	126768	740	79616850
Metastases to bone	67.14	12.74	131	126667	24296	79593294
Cytopenia	66.92	12.74	118	126680	20265	79597325
Pulmonary vascular disorder	66.76	12.74	33	126765	1030	79616560
Heart rate decreased	66.71	12.74	15	126783	70301	79547289
Influenza like illness	66.64	12.74	16	126782	71691	79545899
Hepatitis B	66.56	12.74	74	126724	8258	79609332
Oesophagobronchial fistula	66.19	12.74	22	126776	234	79617356
Pericarditis	66.15	12.74	42	126756	104194	79513396
Maternal exposure during pregnancy	65.72	12.74	72	126726	136466	79481124
Bronchial fistula	65.34	12.74	21	126777	199	79617391
Aplasia	65.15	12.74	71	126727	7749	79609841
Radiation injury	64.59	12.74	30	126768	813	79616777
Malaise	64.01	12.74	486	126312	489383	79128207
B-cell lymphoma recurrent	62.67	12.74	31	126767	969	79616621
Renal tubular necrosis	62.50	12.74	129	126669	24910	79592680
Interstitial lung disease	62.43	12.74	348	126450	112252	79505338
Embolism	62.34	12.74	93	126705	13889	79603701
Cardiac failure congestive	62.25	12.74	81	126717	142321	79475269
Adverse drug reaction	61.33	12.74	15	126783	66377	79551213
Cardiomyopathy	61.25	12.74	139	126659	28635	79588955
Diarrhoea	61.16	12.74	1831	124967	878658	78738932
Duodenal ulcer perforation	61.08	12.74	15	126783	66196	79551394
Polyneuropathy	60.96	12.74	125	126673	24026	79593564
Sleep disorder	60.88	12.74	30	126768	85647	79531943
Acquired gene mutation	60.43	12.74	40	126758	2193	79615397
Cataract	59.44	12.74	13	126785	62107	79555483
Injection site swelling	59.24	12.74	4	126794	47128	79570462
Osteoporosis	59.06	12.74	8	126790	54104	79563486
Bacterial translocation	58.43	12.74	26	126772	636	79616954
Vision blurred	57.73	12.74	50	126748	105848	79511742
Red blood cell sedimentation rate increased	57.45	12.74	4	126794	45938	79571652
Gastrooesophageal reflux disease	57.09	12.74	49	126749	104197	79513393
Salivary gland cancer	57.04	12.74	23	126775	437	79617153
Osteosarcoma metastatic	56.90	12.74	14	126784	42	79617548
Drug clearance decreased	56.63	12.74	45	126753	3282	79614308
Electrocardiogram QT prolonged	56.56	12.74	37	126761	90349	79527241
Hypoaesthesia	56.36	12.74	126	126672	179226	79438364
Pulmonary arteriopathy	56.29	12.74	16	126782	95	79617495
Atypical haemolytic uraemic syndrome	55.93	12.74	29	126769	1003	79616587
Metastases to breast	55.93	12.74	20	126778	269	79617321
Tumour necrosis	55.85	12.74	36	126762	1886	79615704
General physical health deterioration	55.35	12.74	675	126123	274563	79343027
Disseminated intravascular coagulation	55.12	12.74	153	126645	35689	79581901
Sedation	53.60	12.74	9	126789	51886	79565704
Serotonin syndrome	53.31	12.74	5	126793	45022	79572568
Vena cava thrombosis	53.27	12.74	41	126757	2854	79614736
Hypoglycaemia	52.95	12.74	50	126748	101544	79516046
Splenic infarction	52.83	12.74	45	126753	3619	79613971
Ameloblastoma	52.78	12.74	15	126783	89	79617501
Peritonitis	52.68	12.74	129	126669	27907	79589683
Tumour haemorrhage	51.94	12.74	47	126751	4097	79613493
Renal infarct	51.47	12.74	39	126759	2652	79614938
Incorrect dose administered	51.25	12.74	29	126769	76601	79540989
Mantle cell lymphoma recurrent	50.97	12.74	23	126775	582	79617008
Arteriospasm coronary	50.83	12.74	58	126740	6658	79610932
Cerebral infarction	50.69	12.74	174	126624	45502	79572088
Empyema	50.67	12.74	47	126751	4229	79613361
Performance status decreased	50.05	12.74	55	126743	6058	79611532
Fatigue	49.93	12.74	1113	125685	928614	78688976
Anastomotic complication	49.80	12.74	21	126777	449	79617141
Back pain	49.69	12.74	282	126516	303898	79313692
Lymphopenia	49.55	12.74	133	126665	30424	79587166
Neoplasm recurrence	49.32	12.74	46	126752	4168	79613422
Road traffic accident	48.75	12.74	6	126792	43658	79573932
Lower respiratory tract infection	48.21	12.74	82	126716	129138	79488452
Gastrointestinal perforation	48.15	12.74	54	126744	6083	79611507
Hypophosphataemia	47.84	12.74	101	126697	19812	79597778
Tremor	47.53	12.74	127	126671	169956	79447634
Lymphadenopathy	47.48	12.74	189	126609	53058	79564532
Hallucination	47.33	12.74	40	126758	85705	79531885
Fluid retention	47.29	12.74	26	126772	69783	79547807
Blood pressure systolic increased	46.77	12.74	24	126774	66962	79550628
Pulmonary toxicity	46.65	12.74	78	126720	12836	79604754
Heart rate increased	46.53	12.74	75	126723	120649	79496941
Cerebral venous thrombosis	46.36	12.74	37	126761	2716	79614874
Cardiac disorder	45.26	12.74	24	126774	65733	79551857
Tumour perforation	45.24	12.74	19	126779	402	79617188
Confusional state	44.61	12.74	309	126489	317688	79299902
Cholangitis	44.60	12.74	76	126722	12700	79604890
Hypersensitivity	44.53	12.74	240	126558	261999	79355591
Gait inability	44.39	12.74	19	126779	58898	79558692
Progressive multifocal leukoencephalopathy	44.38	12.74	100	126698	20500	79597090
Burning sensation	44.03	12.74	19	126779	58613	79558977
Blood stem cell transplant failure	44.00	12.74	20	126778	515	79617075
Palpitations	43.95	12.74	84	126714	126526	79491064
Product prescribing error	43.65	12.74	9	126789	44804	79572786
Blood sodium decreased	43.51	12.74	134	126664	33121	79584469
Drug withdrawal syndrome	43.48	12.74	3	126795	34715	79582875
Embolism arterial	43.05	12.74	28	126770	1490	79616100
Pneumatosis intestinalis	43.02	12.74	52	126746	6345	79611245
Blood creatine phosphokinase increased	42.80	12.74	26	126772	66064	79551526
Oedema peripheral	42.77	12.74	231	126567	252057	79365533
Aggression	42.46	12.74	14	126784	50944	79566646
Impaired healing	42.42	12.74	46	126752	87609	79529981
Injection site reaction	42.35	12.74	17	126781	54768	79562822
Extremity necrosis	41.89	12.74	37	126761	3124	79614466
Immune-mediated hepatic disorder	41.80	12.74	28	126770	1566	79616024
Hydronephrosis	41.32	12.74	88	126710	17366	79600224
Intestinal ischaemia	41.23	12.74	75	126723	13195	79604395
Chronic obstructive pulmonary disease	41.14	12.74	45	126753	85374	79532216
Fanconi syndrome	41.02	12.74	35	126763	2821	79614769
Necrosis	40.70	12.74	62	126736	9431	79608159
Metastases to peritoneum	40.50	12.74	42	126756	4330	79613260
Hypoalbuminaemia	40.02	12.74	98	126700	21199	79596391
Localised infection	39.97	12.74	6	126792	37569	79580021
Lactic acidosis	39.85	12.74	32	126766	70327	79547263
Radiation mucositis	39.80	12.74	15	126783	236	79617354
Dermatitis acneiform	39.68	12.74	63	126735	9930	79607660
Peripheral sensory neuropathy	39.66	12.74	73	126725	12960	79604630
Cerebral ischaemia	39.62	12.74	67	126731	11128	79606462
Type 2 diabetes mellitus	39.09	12.74	21	126777	57101	79560489
Angioedema	38.95	12.74	38	126760	75997	79541593
Nervousness	38.80	12.74	4	126794	33411	79584179
Small cell lung cancer	38.75	12.74	34	126764	2846	79614744
Sciatica	38.51	12.74	4	126794	33218	79584372
Haemophagocytic lymphohistiocytosis	38.42	12.74	98	126700	21739	79595851
Adrenocortical carcinoma	38.32	12.74	11	126787	68	79617522
Gastrointestinal fungal infection	38.21	12.74	18	126780	504	79617086
Joint stiffness	38.15	12.74	9	126789	40821	79576769
Osteosarcoma recurrent	38.04	12.74	10	126788	42	79617548
Blindness cortical	37.66	12.74	22	126776	965	79616625
Unevaluable event	37.22	12.74	21	126777	55564	79562026
Refeeding syndrome	37.03	12.74	11	126787	78	79617512
Pneumothorax	36.93	12.74	114	126684	28209	79589381
Coronary artery thrombosis	36.54	12.74	34	126764	3072	79614518
Metastases to adrenals	36.42	12.74	24	126774	1306	79616284
Throat irritation	36.38	12.74	10	126788	40936	79576654
Nasal abscess	36.01	12.74	13	126785	180	79617410
Prescribed underdose	35.69	12.74	3	126795	29511	79588079
Abortion spontaneous	35.68	12.74	3	126795	29504	79588086
Gastric disorder	35.48	12.74	8	126790	37425	79580165
Myasthenia gravis crisis	35.25	12.74	22	126776	1089	79616501
Oesophageal perforation	35.09	12.74	25	126773	1546	79616044
Product use issue	35.07	12.74	193	126605	209629	79407961
Upper respiratory tract infection	34.79	12.74	57	126741	91111	79526479
Extravasation	34.69	12.74	36	126762	3714	79613876
Lip swelling	34.51	12.74	11	126787	40900	79576690
Plasma cell leukaemia	34.42	12.74	26	126772	1760	79615830
Obesity	34.32	12.74	7	126791	35118	79582472
Gastrointestinal anastomotic leak	34.32	12.74	17	126781	533	79617057
Blood glucose increased	34.32	12.74	83	126715	114892	79502698
Neoplasm	34.19	12.74	56	126742	9060	79608530
Large intestinal ulcer perforation	34.15	12.74	10	126788	67	79617523
Metastases to meninges	34.09	12.74	35	126763	3566	79614024
Cytokine release syndrome	33.90	12.74	130	126668	35868	79581722
Neurosensory hypoacusis	33.79	12.74	13	126785	217	79617373
Eye pain	33.73	12.74	9	126789	37569	79580021
Musculoskeletal pain	33.72	12.74	70	126728	102284	79515306
Cholelithiasis	33.71	12.74	21	126777	52643	79564947
Candida infection	33.56	12.74	135	126663	38079	79579511
Refractory cancer	33.46	12.74	13	126785	223	79617367
Ear infection	33.36	12.74	7	126791	34425	79583165
Accidental exposure to product	33.32	12.74	5	126793	31317	79586273
Hyperhidrosis	33.28	12.74	126	126672	151366	79466224
Ureteric rupture	33.28	12.74	7	126791	7	79617583
Injection site haemorrhage	33.24	12.74	3	126795	27867	79589723
Coronary artery disease	33.21	12.74	33	126765	65441	79552149
Muscular weakness	33.20	12.74	137	126661	160592	79456998
Frequent bowel movements	33.12	12.74	4	126794	29535	79588055
Labelled drug-drug interaction medication error	32.92	12.74	3	126795	27647	79589943
BK virus infection	32.91	12.74	54	126744	8750	79608840
Melanoderma	32.69	12.74	15	126783	395	79617195
Wernicke's encephalopathy	32.51	12.74	8	126790	24	79617566
Acoustic stimulation tests abnormal	32.51	12.74	8	126790	24	79617566
Skin toxicity	32.44	12.74	52	126746	8262	79609328
Thrombophlebitis	32.43	12.74	45	126753	6290	79611300
Cervix neoplasm	32.30	12.74	12	126786	181	79617409
COVID-19	32.20	12.74	135	126663	157539	79460051
Hepatitis B reactivation	32.19	12.74	44	126754	6064	79611526
Product administration error	31.85	12.74	6	126792	31840	79585750
Blood pressure diastolic decreased	31.74	12.74	5	126793	30211	79587379
Pregnancy	31.73	12.74	3	126795	26848	79590742
Flagellate dermatitis	31.63	12.74	13	126785	260	79617330
Basal cell carcinoma	31.62	12.74	10	126788	37365	79580225
Plasmacytoma	31.60	12.74	37	126761	4366	79613224
Underdose	31.59	12.74	7	126791	33144	79584446
Intestinal perforation	31.49	12.74	79	126719	17347	79600243
Limb discomfort	31.17	12.74	7	126791	32843	79584747
Mesenteric abscess	31.17	12.74	11	126787	142	79617448
Limb injury	30.76	12.74	5	126793	29523	79588067
Hyperammonaemic encephalopathy	30.75	12.74	38	126760	4744	79612846
Intentional product use issue	30.59	12.74	131	126667	151981	79465609
Prescribed overdose	30.54	12.74	11	126787	37872	79579718
Rhinorrhoea	30.51	12.74	46	126752	76028	79541562
Sleep apnoea syndrome	30.43	12.74	10	126788	36468	79581122
Chemical peritonitis	30.40	12.74	13	126785	288	79617302
Myoclonus	30.40	12.74	4	126794	27656	79589934
Folliculitis	30.36	12.74	26	126772	55354	79562236
Hepatic steatosis	30.35	12.74	11	126787	37727	79579863
Tumour thrombosis	30.17	12.74	11	126787	157	79617433
Lymphangiosis carcinomatosa	30.13	12.74	26	126772	2128	79615462
Visceral venous thrombosis	30.13	12.74	7	126791	15	79617575
Emotional distress	29.93	12.74	13	126785	39956	79577634
Toxicity to various agents	29.81	12.74	481	126317	421059	79196531
Blood HIV RNA increased	29.81	12.74	24	126774	1784	79615806
Swelling face	29.60	12.74	42	126756	71170	79546420
Nephritis bacterial	29.46	12.74	8	126790	39	79617551
Medulloblastoma recurrent	29.46	12.74	10	126788	114	79617476
Lymphoma	29.32	12.74	77	126721	17383	79600207
Urinary tract infection	29.24	12.74	287	126511	274225	79343365
Hepatic candidiasis	28.82	12.74	9	126789	77	79617513
Superior mesenteric artery syndrome	28.73	12.74	11	126787	181	79617409
International normalised ratio increased	28.71	12.74	57	126741	84664	79532926
Diaphragm muscle weakness	28.68	12.74	11	126787	182	79617408
Swollen tongue	28.62	12.74	16	126782	42554	79575036
Melanosis	28.51	12.74	8	126790	45	79617545
Dyskinesia	28.45	12.74	18	126780	44755	79572835
Amnesia	28.45	12.74	35	126763	63022	79554568
Irritability	28.34	12.74	15	126783	41129	79576461
Femur fracture	28.27	12.74	13	126785	38639	79578951
Abdominal pain upper	28.25	12.74	224	126574	223595	79393995
Medication error	28.02	12.74	41	126757	68601	79548989
Pancreatitis	27.95	12.74	41	126757	68534	79549056
EGFR gene mutation	27.94	12.74	14	126784	450	79617140
Malnutrition	27.89	12.74	89	126709	22413	79595177
Nightmare	27.81	12.74	4	126794	25857	79591733
Traumatic lung injury	27.79	12.74	26	126772	2365	79615225
Myocardial infarction	27.77	12.74	175	126623	183954	79433636
Cerebellar haemangioma	27.75	12.74	9	126789	88	79617502
Haemoptysis	27.72	12.74	168	126630	55831	79561759
Dry eye	27.68	12.74	12	126786	36919	79580671
Neutrophil count abnormal	27.62	12.74	31	126767	3495	79614095
Metastatic neoplasm	27.61	12.74	37	126761	5005	79612585
Agranulocytosis	27.54	12.74	143	126655	44887	79572703
Enterocolitis	27.50	12.74	67	126731	14445	79603145
Device issue	27.34	12.74	5	126793	27103	79590487
Stress cardiomyopathy	27.25	12.74	57	126741	11109	79606481
Tracheo-oesophageal fistula	27.14	12.74	15	126783	591	79616999
Myeloid leukaemia	27.08	12.74	16	126782	717	79616873
Herpes simplex encephalitis	27.02	12.74	16	126782	720	79616870
Intervertebral disc protrusion	26.98	12.74	3	126795	23618	79593972
Aortitis	26.98	12.74	21	126777	1486	79616104
Dyspnoea	26.97	12.74	1102	125696	855923	78761667
Poisoning	26.96	12.74	4	126794	25268	79592322
Clostridium bacteraemia	26.93	12.74	13	126785	385	79617205
Therapy cessation	26.91	12.74	13	126785	37549	79580041
Nephrolithiasis	26.87	12.74	27	126771	53264	79564326
Testicular malignant teratoma	26.81	12.74	6	126792	10	79617580
Right ventricular failure	26.80	12.74	3	126795	23494	79594096
Lymphadenopathy mediastinal	26.78	12.74	34	126764	4362	79613228
Haemoglobin decreased	26.73	12.74	499	126299	221620	79395970
Tracheal stenosis	26.71	12.74	13	126785	392	79617198
Hepatic cirrhosis	26.71	12.74	11	126787	34895	79582695
Agitation	26.69	12.74	76	126722	99639	79517951
Necrotising colitis	26.63	12.74	18	126780	1022	79616568
Liver abscess	26.61	12.74	40	126758	6014	79611576
Hip fracture	26.43	12.74	8	126790	30753	79586837
Rib fracture	26.43	12.74	6	126792	27941	79589649
Gout	26.21	12.74	4	126794	24745	79592845
Blood glucose decreased	26.11	12.74	5	126793	26229	79591361
Device related infection	26.11	12.74	116	126682	34178	79583412
Failure to thrive	26.08	12.74	58	126740	11786	79605804
Papillary thyroid cancer	26.06	12.74	26	126772	2560	79615030
Erythropenia	25.94	12.74	13	126785	418	79617172
Alpha 1 foetoprotein increased	25.64	12.74	16	126782	792	79616798
Acne	25.39	12.74	6	126792	27184	79590406
Ascites	25.24	12.74	206	126592	75356	79542234
Cystitis	25.15	12.74	28	126770	52704	79564886
Multiple sclerosis	25.03	12.74	3	126795	22279	79595311
Acute promyelocytic leukaemia	25.02	12.74	20	126778	1471	79616119
Ileus	24.96	12.74	95	126703	26116	79591474
Varicella zoster virus infection	24.95	12.74	33	126765	4408	79613182
Blood magnesium decreased	24.91	12.74	70	126728	16442	79601148
Cerebral venous sinus thrombosis	24.89	12.74	24	126774	2267	79615323
Pain in jaw	24.89	12.74	22	126776	46129	79571461
Encephalopathy	24.86	12.74	188	126610	67209	79550381
Hepatic function abnormal	24.80	12.74	200	126598	72907	79544683
Diabetes mellitus	24.67	12.74	55	126743	78335	79539255
Joint range of motion decreased	24.65	12.74	11	126787	33271	79584319
Wound evisceration	24.65	12.74	9	126789	129	79617461
Klebsiella test positive	24.51	12.74	21	126777	1702	79615888
Sopor	24.31	12.74	11	126787	32999	79584591
Granulocyte-colony stimulating factor level increased	24.30	12.74	5	126793	4	79617586
Metastases to pleura	24.30	12.74	20	126778	1534	79616056
Dysstasia	24.24	12.74	7	126791	27739	79589851
Multiple organ dysfunction syndrome	24.17	12.74	295	126503	119951	79497639
Product quality issue	23.93	12.74	12	126786	33928	79583662
Crying	23.79	12.74	4	126794	23039	79594551
Hypogammaglobulinaemia	23.70	12.74	59	126739	12892	79604698
Asthenia	23.70	12.74	1017	125781	510672	79106918
Accidental overdose	23.69	12.74	17	126781	39564	79578026
Ovarian vein thrombosis	23.64	12.74	7	126791	49	79617541
Movement disorder	23.59	12.74	7	126791	27252	79590338
Adverse event	23.58	12.74	37	126761	60177	79557413
Subclavian vein thrombosis	23.48	12.74	24	126774	2433	79615157
Gene mutation	23.45	12.74	25	126773	2661	79614929
Fanconi syndrome acquired	23.39	12.74	25	126773	2669	79614921
Plasma cell myeloma recurrent	23.36	12.74	34	126764	4967	79612623
Iron deficiency anaemia	23.32	12.74	6	126792	25666	79591924
Sinus polyp	23.23	12.74	13	126785	525	79617065
Stem cell transplant	23.12	12.74	29	126769	3675	79613915
Prostate cancer	23.10	12.74	12	126786	33256	79584334
Immune-mediated lung disease	23.04	12.74	23	126775	2267	79615323
Transient ischaemic attack	22.99	12.74	30	126768	52665	79564925
Hallucination, auditory	22.72	12.74	3	126795	20690	79596900
Immune-mediated myocarditis	22.70	12.74	17	126781	1136	79616454
Retroperitoneal neoplasm metastatic	22.67	12.74	6	126792	26	79617564
Haematoma	22.48	12.74	30	126768	52165	79565425
Bradycardia	22.47	12.74	125	126673	135432	79482158
Clostridium colitis	22.31	12.74	25	126773	2814	79614776
Tooth disorder	22.22	12.74	7	126791	26226	79591364
Cannabinoid hyperemesis syndrome	22.20	12.74	7	126791	62	79617528
Liver function test abnormal	22.17	12.74	43	126755	64432	79553158
Streptococcal bacteraemia	22.14	12.74	28	126770	3578	79614012
Immune-mediated dermatitis	22.11	12.74	13	126785	577	79617013
Pharyngeal inflammation	22.11	12.74	16	126782	1014	79616576
Retinopathy	21.99	12.74	29	126769	3862	79613728
Gastrointestinal necrosis	21.98	12.74	35	126763	5530	79612060
Staphylococcus test positive	21.90	12.74	38	126760	6443	79611147
Granulocyte count decreased	21.67	12.74	20	126778	1788	79615802
Recurrent cancer	21.65	12.74	24	126774	2669	79614921
Chromaturia	21.58	12.74	7	126791	25739	79591851
Lung cancer metastatic	21.57	12.74	28	126770	3671	79613919
Muscle spasticity	21.57	12.74	4	126794	21471	79596119
Mood swings	21.55	12.74	3	126795	19877	79597713
Chest discomfort	21.43	12.74	130	126668	137914	79479676
Transitional cell carcinoma recurrent	21.43	12.74	5	126793	11	79617579
Gingivitis ulcerative	21.39	12.74	10	126788	275	79617315
Unmasking of previously unidentified disease	21.32	12.74	21	126777	2036	79615554
Arteritis	21.28	12.74	15	126783	912	79616678
Axillary vein thrombosis	21.23	12.74	13	126785	622	79616968
Renal tubular dysfunction	21.22	12.74	14	126784	763	79616827
Extrapyramidal disorder	21.19	12.74	5	126793	22674	79594916
Staphylococcal infection	21.16	12.74	162	126636	58133	79559457
Angina pectoris	21.02	12.74	31	126767	51701	79565889
Aortic embolus	21.01	12.74	7	126791	75	79617515
Heart rate irregular	20.96	12.74	13	126785	32666	79584924
Acquired tracheo-oesophageal fistula	20.93	12.74	8	126790	131	79617459
Amputation stump pain	20.92	12.74	6	126792	37	79617553
Sinus disorder	20.89	12.74	5	126793	22459	79595131
Metastases to abdominal cavity	20.70	12.74	13	126785	651	79616939
Hypercalcaemia of malignancy	20.69	12.74	11	126787	401	79617189
Purulent pericarditis	20.61	12.74	7	126791	80	79617510
Bone marrow disorder	20.59	12.74	26	126772	3317	79614273
Blood culture positive	20.53	12.74	43	126755	8386	79609204
Clonal haematopoiesis	20.52	12.74	6	126792	40	79617550
Eye irritation	20.46	12.74	4	126794	20677	79596913
Fistula of small intestine	20.43	12.74	14	126784	813	79616777
Enterocolitis infectious	20.41	12.74	24	126774	2845	79614745
Myelitis transverse	20.41	12.74	20	126778	1927	79615663
Jaw operation	20.40	12.74	14	126784	815	79616775
Candida pneumonia	20.39	12.74	13	126785	668	79616922
Sarcomatoid carcinoma	20.39	12.74	6	126792	41	79617549
Dysphonia	20.38	12.74	37	126761	56835	79560755
Eye pruritus	20.31	12.74	4	126794	20566	79597024
Embryonal rhabdomyosarcoma	20.26	12.74	6	126792	42	79617548
Liver function test increased	20.22	12.74	20	126778	39753	79577837
Pneumonia	20.12	12.74	1261	125537	658985	78958605
Disturbance in attention	20.10	12.74	31	126767	50770	79566820
Iliac artery occlusion	20.09	12.74	10	126788	317	79617273
Abnormal behaviour	20.08	12.74	17	126781	36404	79581186
Gastrointestinal obstruction	20.08	12.74	19	126779	1753	79615837
Uterine atrophy	20.08	12.74	5	126793	16	79617574
Adrenal insufficiency	19.93	12.74	94	126704	28393	79589197
Apparent mineralocorticoid excess	19.91	12.74	6	126792	45	79617545
Viral load increased	19.89	12.74	24	126774	2924	79614666
Subcutaneous emphysema	19.88	12.74	19	126779	1775	79615815
Meningitis tuberculous	19.87	12.74	16	126782	1189	79616401
Hypersomnia	19.84	12.74	6	126792	23080	79594510
Haematochezia	19.83	12.74	72	126726	87573	79530017
Neck pain	19.80	12.74	58	126740	75359	79542231
Depressed mood	19.74	12.74	29	126769	48451	79569139
Surgery	19.71	12.74	14	126784	32752	79584838
Alveolar soft part sarcoma	19.65	12.74	7	126791	93	79617497
Hyperpyrexia	19.65	12.74	35	126763	6057	79611533
Staphylococcal bacteraemia	19.62	12.74	53	126745	12165	79605425
Azoospermia	19.60	12.74	8	126790	157	79617433
Breast cancer	19.59	12.74	15	126783	33766	79583824
Oroticaciduria	19.55	12.74	4	126794	3	79617587
Oesophageal squamous cell carcinoma metastatic	19.55	12.74	4	126794	3	79617587
Systemic infection	19.53	12.74	46	126752	9706	79607884
Myositis	19.53	12.74	71	126727	19097	79598493
Haemoperitoneum	19.52	12.74	29	126769	4314	79613276
Ischaemic stroke	19.43	12.74	104	126694	33027	79584563
Hot flush	19.40	12.74	36	126762	54841	79562749
Anti-Muellerian hormone level decreased	19.38	12.74	7	126791	97	79617493
Therapy interrupted	19.37	12.74	13	126785	31328	79586262
Sinus congestion	19.37	12.74	4	126794	19892	79597698
Mucosal toxicity	19.34	12.74	12	126786	588	79617002
Hypovolaemia	19.28	12.74	67	126731	17624	79599966
Lung abscess	19.27	12.74	28	126770	4084	79613506
Chemotherapeutic drug level increased	19.26	12.74	10	126788	347	79617243
Carotid artery dissection	19.26	12.74	10	126788	347	79617243
Pharyngeal stenosis	19.21	12.74	5	126793	20	79617570
Glaucoma	19.18	12.74	4	126794	19757	79597833
Abdominal neoplasm	19.17	12.74	12	126786	597	79616993
Enterococcal bacteraemia	19.12	12.74	24	126774	3044	79614546
Thrombocytopenia neonatal	19.02	12.74	5	126793	21	79617569
Maternal death affecting foetus	19.02	12.74	4	126794	4	79617586
Trigeminal nerve paresis	19.02	12.74	4	126794	4	79617586
Adenoviral hepatitis	18.99	12.74	14	126784	913	79616677
Ureteric dilatation	18.89	12.74	8	126790	173	79617417
Dry mouth	18.82	12.74	74	126724	87945	79529645
Granulocytopenia	18.78	12.74	50	126748	11381	79606209
Transplant rejection	18.73	12.74	4	126794	19433	79598157
Retinal ischaemia	18.67	12.74	13	126785	775	79616815
Bone erosion	18.64	12.74	3	126795	17844	79599746
Muscle twitching	18.63	12.74	8	126790	24756	79592834
Renal tubular injury	18.59	12.74	17	126781	1502	79616088
Eosinophilia	18.59	12.74	27	126771	45318	79572272
Testicular germ cell cancer metastatic	18.47	12.74	6	126792	59	79617531
Pneumonia adenoviral	18.45	12.74	11	126787	501	79617089
Immune-mediated renal disorder	18.39	12.74	8	126790	185	79617405
Choriocarcinoma	18.38	12.74	6	126792	60	79617530
Chemotherapy	18.33	12.74	18	126780	1739	79615851
Metastases to abdominal wall	18.24	12.74	8	126790	189	79617401
Colitis ulcerative	18.21	12.74	17	126781	34725	79582865
Sweat gland tumour	18.14	12.74	11	126787	517	79617073
Delusion	18.12	12.74	5	126793	20418	79597172
Organising pneumonia	18.12	12.74	48	126750	10891	79606699
Visual impairment	18.12	12.74	80	126718	92051	79525539
Procedural pain	18.11	12.74	7	126791	23077	79594513
Metastases to retroperitoneum	18.09	12.74	10	126788	394	79617196
Mental disorder	18.02	12.74	14	126784	31288	79586302
Vaginitis gardnerella	17.99	12.74	5	126793	27	79617563
Testicular cancer metastatic	17.95	12.74	6	126792	65	79617525
Thrombocytosis	17.93	12.74	41	126757	8485	79609105
Campylobacter test positive	17.79	12.74	6	126792	67	79617523
Small intestinal perforation	17.75	12.74	24	126774	3273	79614317
Peritoneal gliomatosis	17.75	12.74	4	126794	7	79617583
Body temperature decreased	17.73	12.74	15	126783	32130	79585460
Hypertension	17.72	12.74	396	126402	330596	79286994
Alopecia	17.68	12.74	260	126538	231095	79386495
Restless legs syndrome	17.68	12.74	5	126793	20087	79597503
Cerebral salt-wasting syndrome	17.56	12.74	7	126791	129	79617461
Hepatic lesion	17.54	12.74	36	126762	6923	79610667
Hernia	17.52	12.74	3	126795	17056	79600534
Vertigo	17.51	12.74	54	126744	69028	79548562
Cardiac pseudoaneurysm	17.47	12.74	6	126792	71	79617519
Rash pruritic	17.45	12.74	57	126741	71572	79546018
Median nerve injury	17.41	12.74	5	126793	31	79617559
Oral candidiasis	17.37	12.74	93	126705	29535	79588055
Malignant pleural effusion	17.29	12.74	24	126774	3356	79614234
Oxygen saturation decreased	17.29	12.74	127	126671	128920	79488670
Primitive neuroectodermal tumour	17.27	12.74	5	126793	32	79617558
Acute myelomonocytic leukaemia	17.26	12.74	9	126789	315	79617275
Paraneoplastic dermatomyositis	17.25	12.74	6	126792	74	79617516
Anaplastic lymphoma kinase gene mutation	17.22	12.74	7	126791	136	79617454
Ovarian cancer recurrent	17.21	12.74	10	126788	434	79617156
Embolism venous	17.21	12.74	27	126771	4212	79613378
Gastroenteritis viral	17.18	12.74	9	126789	24822	79592768
Pneumonia escherichia	17.12	12.74	13	126785	887	79616703
Morphoea	17.11	12.74	10	126788	439	79617151
Jugular vein occlusion	17.08	12.74	4	126794	9	79617581
Laryngeal pain	17.06	12.74	33	126765	6081	79611509
Venous thrombosis	16.98	12.74	36	126762	7080	79610510
Dementia	16.97	12.74	9	126789	24650	79592940
Cough	16.86	12.74	449	126349	366340	79251250
Ganglioneuroma	16.85	12.74	7	126791	144	79617446
Dropped head syndrome	16.80	12.74	9	126789	333	79617257
Cellulitis	16.77	12.74	103	126695	108957	79508633
Malassezia infection	16.77	12.74	5	126793	36	79617554
Upper limb fracture	16.71	12.74	4	126794	17963	79599627
Metastases to the mediastinum	16.68	12.74	11	126787	599	79616991
Dry skin	16.64	12.74	54	126744	67941	79549649
Vascular injury	16.64	12.74	14	126784	1107	79616483
B-cell lymphoma refractory	16.59	12.74	7	126791	150	79617440
Kidney infection	16.53	12.74	7	126791	21844	79595746
Leukaemic lymphoma	16.49	12.74	6	126792	85	79617505
Enterococcal sepsis	16.47	12.74	21	126777	2705	79614885
Nephropathy	16.41	12.74	43	126755	9695	79607895
Sepsis pasteurella	16.34	12.74	3	126795	0	79617590
Deafness congenital	16.34	12.74	3	126795	0	79617590
Oesophageal squamous cell carcinoma recurrent	16.34	12.74	3	126795	0	79617590
Procedural vomiting	16.33	12.74	12	126786	779	79616811
Skin exfoliation	16.26	12.74	40	126758	55060	79562530
Metapneumovirus bronchiolitis	16.26	12.74	4	126794	12	79617578
Cervix carcinoma recurrent	16.26	12.74	4	126794	12	79617578
Osteomyelitis	16.17	12.74	17	126781	32848	79584742
Gastrointestinal ischaemia	16.17	12.74	10	126788	487	79617103
Incorrect route of product administration	16.16	12.74	19	126779	34910	79582680
Depressed level of consciousness	16.08	12.74	89	126709	96563	79521027
Poor quality sleep	16.07	12.74	8	126790	22714	79594876
Marchiafava-Bignami disease	16.02	12.74	4	126794	13	79617577
Oesophageal squamous cell carcinoma	16.01	12.74	10	126788	496	79617094
Adrenocorticotropic hormone deficiency	15.98	12.74	15	126783	1370	79616220
Pericardial effusion	15.95	12.74	127	126671	46110	79571480
Pelvic fluid collection	15.95	12.74	12	126786	807	79616783
Capillary leak syndrome	15.94	12.74	25	126773	3900	79613690
Hyperlipidaemia	15.89	12.74	11	126787	26082	79591508
Live birth	15.88	12.74	5	126793	18739	79598851
Obstructive airways disorder	15.79	12.74	16	126782	31443	79586147
Retinal toxicity	15.74	12.74	15	126783	1396	79616194
Enterobacter infection	15.74	12.74	27	126771	4535	79613055
Spinal stenosis	15.74	12.74	3	126795	15788	79601802
Dyspnoea exertional	15.71	12.74	78	126720	86995	79530595
Portal vein thrombosis	15.71	12.74	31	126767	5796	79611794
Cardiac tamponade	15.67	12.74	41	126757	9235	79608355
Myasthenic syndrome	15.66	12.74	12	126786	830	79616760
Acute monocytic leukaemia	15.43	12.74	10	126788	529	79617061
Oral fungal infection	15.42	12.74	24	126774	3719	79613871
Noctiphobia	15.37	12.74	4	126794	16	79617574
Paraneoplastic syndrome	15.35	12.74	13	126785	1037	79616553
White blood cell disorder	15.34	12.74	22	126776	3170	79614420
Herpes zoster	15.33	12.74	86	126712	92997	79524593
Blood loss anaemia	15.33	12.74	3	126795	15495	79602095
Unresponsive to stimuli	15.31	12.74	42	126756	55746	79561844
Blood iron decreased	15.24	12.74	3	126795	15431	79602159
Night sweats	15.23	12.74	38	126760	52057	79565533
Carpal tunnel syndrome	15.19	12.74	6	126792	19522	79598068
Vascular pseudoaneurysm	15.15	12.74	23	126775	3487	79614103
Diabetes mellitus inadequate control	15.08	12.74	10	126788	24254	79593336
Paranoia	15.07	12.74	6	126792	19426	79598164
Fracture	14.94	12.74	8	126790	21793	79595797
Necrosis ischaemic	14.93	12.74	13	126785	1077	79616513
Thrombotic thrombocytopenic purpura	14.92	12.74	32	126766	6344	79611246
Glycosylated haemoglobin increased	14.85	12.74	6	126792	19254	79598336
Metastases to thorax	14.73	12.74	7	126791	200	79617390
Mood altered	14.70	12.74	5	126793	17842	79599748
Skin ulcer	14.69	12.74	41	126757	54109	79563481
Evans syndrome	14.67	12.74	9	126789	432	79617158
Hypoglossal nerve paresis	14.64	12.74	6	126792	119	79617471
Immune-mediated enterocolitis	14.63	12.74	27	126771	4803	79612787
Carotid artery thrombosis	14.61	12.74	21	126777	3032	79614558
Hypoxia	14.58	12.74	238	126560	103005	79514585
Respiratory arrest	14.58	12.74	45	126753	57505	79560085
Thrombophlebitis migrans	14.56	12.74	9	126789	438	79617152
Intestinal infarction	14.52	12.74	14	126784	1322	79616268
Device malfunction	14.51	12.74	8	126790	21440	79596150
Gastroenteritis pseudomonas	14.50	12.74	5	126793	60	79617530
Pneumonia salmonella	14.50	12.74	5	126793	60	79617530
Coma	14.49	12.74	97	126701	100552	79517038
Mydriasis	14.43	12.74	5	126793	17638	79599952
Haemorrhoids	14.41	12.74	15	126783	29113	79588477
BRAF gene mutation	14.35	12.74	5	126793	62	79617528
Hyperglycaemic hyperosmolar nonketotic syndrome	14.33	12.74	18	126780	2285	79615305
Toxic leukoencephalopathy	14.29	12.74	13	126785	1141	79616449
Thymus enlargement	14.28	12.74	6	126792	127	79617463
Eastern Cooperative Oncology Group performance status worsened	14.24	12.74	17	126781	2048	79615542
Mucosal erosion	14.23	12.74	18	126780	2300	79615290
Eczema	14.23	12.74	27	126771	40791	79576799
Chest pain	14.19	12.74	341	126457	281963	79335627
Conjunctivitis	14.18	12.74	12	126786	25703	79591887
Cell-mediated immune deficiency	14.16	12.74	6	126792	130	79617460
Laryngitis	14.10	12.74	4	126794	16035	79601555
Platelet transfusion	14.09	12.74	18	126780	2324	79615266
Pulmonary artery thrombosis	14.04	12.74	14	126784	1378	79616212
Feeling cold	13.98	12.74	15	126783	28714	79588876
Laryngeal cancer stage IV	13.90	12.74	4	126794	25	79617565
Stent malfunction	13.87	12.74	5	126793	69	79617521
Sneezing	13.82	12.74	7	126791	19676	79597914
Drug level decreased	13.80	12.74	3	126795	14399	79603191
Oesophageal prosthesis insertion	13.80	12.74	3	126795	4	79617586
VIth nerve paresis	13.79	12.74	6	126792	139	79617451
Endothelial dysfunction	13.77	12.74	7	126791	232	79617358
Fear	13.75	12.74	9	126789	21977	79595613
Pseudocellulitis	13.73	12.74	5	126793	71	79617519
Culture urine positive	13.69	12.74	25	126773	4410	79613180
Vitamin D deficiency	13.63	12.74	3	126795	14276	79603314
Neoplasm malignant	13.62	12.74	92	126706	31718	79585872
Conductive deafness	13.61	12.74	7	126791	238	79617352
Mania	13.58	12.74	6	126792	18254	79599336
Metastases to pelvis	13.57	12.74	10	126788	652	79616938
Adenocarcinoma of appendix	13.55	12.74	5	126793	74	79617516
Delirium	13.50	12.74	79	126719	84548	79533042
Procedural nausea	13.50	12.74	11	126787	832	79616758
Infective spondylitis	13.41	12.74	9	126789	505	79617085
Post procedural diarrhoea	13.41	12.74	10	126788	664	79616926
Spinal column injury	13.39	12.74	17	126781	2181	79615409
Rotator cuff syndrome	13.38	12.74	3	126795	14092	79603498
Ovarian failure	13.38	12.74	10	126788	666	79616924
Non-small cell lung cancer metastatic	13.38	12.74	12	126786	1034	79616556
Pneumocystis jirovecii pneumonia	13.32	12.74	93	126705	32415	79585175
Hypothermia	13.31	12.74	10	126788	22736	79594854
Squamous cell carcinoma of the cervix	13.30	12.74	7	126791	250	79617340
Colony stimulating factor therapy	13.25	12.74	9	126789	515	79617075
Hemianopia	13.21	12.74	15	126783	1713	79615877
Injection site rash	13.19	12.74	6	126792	17948	79599642
Intestinal metastasis	13.16	12.74	8	126790	378	79617212
Treatment noncompliance	13.15	12.74	41	126757	52227	79565363
Streptococcus test positive	13.15	12.74	17	126781	2221	79615369
Gastroenteritis sapovirus	13.11	12.74	6	126792	157	79617433
Dystonia	13.06	12.74	9	126789	21390	79596200
Peritoneal sarcoma	13.05	12.74	3	126795	6	79617584
Ecchymosis	12.98	12.74	4	126794	15202	79602388
Adenocarcinoma gastric	12.98	12.74	15	126783	1746	79615844
Metastases to kidney	12.95	12.74	9	126789	535	79617055
Facial paralysis	12.94	12.74	67	126731	21005	79596585
Chromosomal deletion	12.94	12.74	6	126792	162	79617428
Oesophageal haemorrhage	12.94	12.74	15	126783	1752	79615838
Brachiocephalic vein thrombosis	12.90	12.74	7	126791	266	79617324
Malignant peritoneal neoplasm	12.89	12.74	10	126788	704	79616886
Retroperitoneal lymphadenopathy	12.86	12.74	12	126786	1088	79616502
Synovial sarcoma	12.86	12.74	5	126793	86	79617504
Blastic plasmacytoid dendritic cell neoplasia	12.86	12.74	5	126793	86	79617504
Respiratory depression	12.82	12.74	15	126783	27615	79589975
Drug-device interaction	12.81	12.74	5	126793	87	79617503
Lymphangioleiomyomatosis	12.77	12.74	6	126792	167	79617423
Hepatic artery occlusion	12.75	12.74	5	126793	88	79617502

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01XA01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Platinum compounds
FDA EXT	N0000175073	Platinum-containing Compounds
FDA EPC	N0000175413	Platinum-based Drug
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D003432	Cross-Linking Reagents
MeSH PA	D007202	Indicators and Reagents
MeSH PA	D011838	Radiation-Sensitizing Agents
CHEBI has role	CHEBI:25435	mutagens
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:47868	photosensitising agent
CHEBI has role	CHEBI:50684	cross-linking reagents
CHEBI has role	CHEBI:50902	genotoxic agent
CHEBI has role	CHEBI:61015	nephrotoxins
CHEBI has role	CHEBI:68495	Type I cell-death inducers
CHEBI has role	CHEBI:173085	ferroptosis inducers

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Malignant tumor of ovary	indication	363443007	DOID:2394
Ovarian Germ Cell Tumor Carcinoma	indication
Testicular Germ Cell Tumor	indication
Invasive Bladder Malignancy	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	5.95		CHEMBL
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	5.37		CHEMBL
Canalicular multispecific organic anion transporter 1	Transporter	Q92887	MRP2_HUMAN					WOMBAT-PK
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.62		DRUG MATRIX
Multidrug resistance-associated protein 6	Transporter	O95255	MRP6_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 5	Transporter	O15440	MRP5_HUMAN					WOMBAT-PK
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN		IC50	5.58		DRUG MATRIX
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN		IC50	4.64		DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	5.32		DRUG MATRIX
C-X-C chemokine receptor type 2	GPCR	P25025	CXCR2_HUMAN		Ki	5.02		DRUG MATRIX
Thromboxane-A synthase	Enzyme	P24557	THAS_HUMAN		IC50	5.03		DRUG MATRIX
C-C chemokine receptor type 2	GPCR	P41597	CCR2_HUMAN		Ki	5.15		DRUG MATRIX
Mitogen-activated protein kinase 3	Kinase	P27361	MK03_HUMAN		IC50	5.34		DRUG MATRIX
Melanocortin receptor 5	GPCR	P33032	MC5R_HUMAN		Ki	5.22		DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-2	Ion channel		AT1A2_PIG		IC50	5.03		DRUG MATRIX

External reference:

ID	Source
D00275	KEGG_DRUG
4018139	VUID
N0000146476	NUI
4018139	VANDF
C0008838	UMLSCUI
CHEBI:27899	CHEBI
CPT	PDB_CHEM_ID
CHEMBL1386	ChEMBL_ID
CHEMBL11359	ChEMBL_ID
CHEMBL2068237	ChEMBL_ID
DB00515	DRUGBANK_ID
5343	IUPHAR_LIGAND_ID
4426	INN_ID
Q20Q21Q62J	UNII
5702198	PUBCHEM_CID
2555	RXNORM
31747	MMSL
4456	MMSL
d00195	MMSL
002641	NDDF
387318005	SNOMEDCT_US
57066004	SNOMEDCT_US
D002945	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9504	INJECTION	1 mg	INTRAVENOUS	ANDA	19 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9505	INJECTION	1 mg	INTRAVENOUS	ANDA	19 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5747	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5747	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5748	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5748	INJECTION, SOLUTION	100 mg	INTRAVENOUS	ANDA	29 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	16729-288	INJECTION	1 mg	INTRAVENOUS	ANDA	26 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	25021-253	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	21 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-509	INJECTION, SOLUTION	1 mg	INTRAVENOUS	NDA	19 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-510	INJECTION, SOLUTION	1 mg	INTRAVENOUS	NDA	19 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-511	INJECTION, SOLUTION	1 mg	INTRAVENOUS	NDA	19 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	44567-530	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	1 mg	INTRAVENOUS	NDA	26 sections
CISplatin	HUMAN PRESCRIPTION DRUG LABEL	1	60505-6277	INJECTION, SOLUTION	50 mg	INTRAVENOUS	Unapproved drug for use in drug shortage	2 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	63323-103	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	68001-283	INJECTION	1 mg	INTRAVENOUS	ANDA	26 sections
CISPLATIN	Human Prescription Drug Label	1	68083-162	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections
CISPLATIN	Human Prescription Drug Label	1	68083-163	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections
Cisplatin	HUMAN PRESCRIPTION DRUG LABEL	1	70860-206	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	21 sections
CISPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	72266-252	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections
CISPLATIN	HUMAN PRESCRIPTION DRUG LABEL	1	72266-253	INJECTION, SOLUTION	1 mg	INTRAVENOUS	ANDA	13 sections