bupranolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| beta-adrenoreceptor antagonists | 433 | 14556-46-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An adrenergic-beta-2 antagonist that has been used for cardiac arrhythmia, angina pectoris, hypertension, glaucoma, and as an antithrombotic.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 7.41 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C07AA19 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, non-selective |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D000319 | Adrenergic beta-Antagonists |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Glaucoma | indication | 23986001 | DOID:1686 |
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.31 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 9 | IUPHAR | IUPHAR | |||
| Beta-2 adrenergic receptor | GPCR | ANTAGONIST | Ki | 9.10 | IUPHAR | IUPHAR | |||
| Beta-3 adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.30 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| N0000166825 | NUI |
| D01454 | KEGG_DRUG |
| 15148-80-8 | SECONDARY_CAS_RN |
| 1817 | RXNORM |
| C0006403 | UMLSCUI |
| CHEBI:135123 | CHEBI |
| CHEMBL305380 | ChEMBL_ID |
| DB08808 | DRUGBANK_ID |
| D002046 | MESH_DESCRIPTOR_UI |
| 2475 | PUBCHEM_CID |
| 550 | IUPHAR_LIGAND_ID |
| 3166 | INN_ID |
| 858YGI5PIT | UNII |
| 006894 | NDDF |
| 006895 | NDDF |
Pharmaceutical products:
None