laropiprant 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prostaglandin receptors antagonists, non-prostanoids | 4326 | 571170-77-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a potent orally active human prostaglandin D(2) receptor 1 antagonist
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 1 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.21 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 11.80 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dyslipidemia | indication | 370992007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.04 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin D2 receptor | GPCR | ANTAGONIST | Kd | 10.52 | CHEMBL | SCIENTIFIC LITERATURE | |||
| Prostaglandin E2 receptor EP1 subtype | GPCR | Ki | 5.94 | CHEMBL | |||||
| Prostaglandin D2 receptor 2 | GPCR | Ki | 6.13 | CHEMBL | |||||
| Prostaglandin E2 receptor EP3 subtype | GPCR | Ki | 6.05 | CHEMBL | |||||
| Prostacyclin receptor | GPCR | Ki | 5.18 | CHEMBL | |||||
| Prostaglandin E2 receptor EP2 subtype | GPCR | Ki | 6.87 | CHEMBL | |||||
| Prostaglandin F2-alpha receptor | GPCR | Ki | 5 | CHEMBL | |||||
| Thromboxane A2 receptor | GPCR | Ki | 8.53 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08940 | KEGG_DRUG |
| C1956497 | UMLSCUI |
| CHEBI:135942 | CHEBI |
| CHEMBL426559 | ChEMBL_ID |
| DB11629 | DRUGBANK_ID |
| C518174 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3356 | IUPHAR_LIGAND_ID |
| 8855 | INN_ID |
| G7N11T8O78 | UNII |
| 9867642 | PUBCHEM_CID |
| 013266 | NDDF |
Pharmaceutical products:
None