laropiprant Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandin receptors antagonists, non-prostanoids 4326 571170-77-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • laropiprant
  • MK 0524
  • MK-0524
a potent orally active human prostaglandin D(2) receptor 1 antagonist
  • Molecular weight: 435.89
  • Formula: C21H19ClFNO4S
  • CLOGP: 3.87
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 76.37
  • ALOGS: -5.01
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.21 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dyslipidemia indication 370992007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.04 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin D2 receptor GPCR ANTAGONIST Kd 10.52 CHEMBL SCIENTIFIC LITERATURE
Prostaglandin F2-alpha receptor GPCR Ki 5 CHEMBL
Prostacyclin receptor GPCR Ki 5.18 CHEMBL
Prostaglandin E2 receptor EP2 subtype GPCR Ki 6.87 CHEMBL
Prostaglandin E2 receptor EP3 subtype GPCR Ki 6.05 CHEMBL
Prostaglandin D2 receptor 2 GPCR Ki 6.13 CHEMBL
Thromboxane A2 receptor GPCR Ki 8.53 CHEMBL
Prostaglandin E2 receptor EP1 subtype GPCR Ki 5.94 CHEMBL

External reference:

IDSource
D08940 KEGG_DRUG
C1956497 UMLSCUI
CHEBI:135942 CHEBI
CHEMBL426559 ChEMBL_ID
DB11629 DRUGBANK_ID
C518174 MESH_SUPPLEMENTAL_RECORD_UI
3356 IUPHAR_LIGAND_ID
8855 INN_ID
G7N11T8O78 UNII
9867642 PUBCHEM_CID
013266 NDDF

Pharmaceutical products:

None