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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
laropiprant 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
prostaglandin receptors antagonists, non-prostanoids
4326
571170-77-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
laropiprant
MK 0524
MK-0524
a potent orally active human prostaglandin D(2) receptor 1 antagonist
Molecular weight: 435.89
Formula: C21H19ClFNO4S
CLOGP: 3.87
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 76.37
ALOGS: -5.01
ROTB: 5
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
11.80 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
1.21 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
1 L/kg
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Dyslipidemia
indication
370992007
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
5.04
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prostaglandin D2 receptor
GPCR
Q13258
PD2R_HUMAN
ANTAGONIST
Kd
10.52
CHEMBL
SCIENTIFIC LITERATURE
Prostaglandin E2 receptor EP1 subtype
GPCR
P34995
PE2R1_HUMAN
Ki
5.94
CHEMBL
Prostaglandin D2 receptor 2
GPCR
Q9Y5Y4
PD2R2_HUMAN
Ki
6.13
CHEMBL
Prostaglandin E2 receptor EP3 subtype
GPCR
P43115
PE2R3_HUMAN
Ki
6.05
CHEMBL
Prostacyclin receptor
GPCR
P43119
PI2R_HUMAN
Ki
5.18
CHEMBL
Prostaglandin E2 receptor EP2 subtype
GPCR
P43116
PE2R2_HUMAN
Ki
6.87
CHEMBL
Prostaglandin F2-alpha receptor
GPCR
P43088
PF2R_HUMAN
Ki
5
CHEMBL
Thromboxane A2 receptor
GPCR
P21731
TA2R_HUMAN
Ki
8.53
CHEMBL
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External reference:
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ID
Source
013266
NDDF
3356
IUPHAR_LIGAND_ID
8855
INN_ID
9867642
PUBCHEM_CID
C1956497
UMLSCUI
C518174
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135942
CHEBI
CHEMBL426559
ChEMBL_ID
D08940
KEGG_DRUG
DB11629
DRUGBANK_ID
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Pharmaceutical products:
None
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laropiprant