allantoin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antiepileptics, hydantoin derivatives 4268 97-59-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • allantoin
  • 5-Ureidohydantoin
  • allantion
  • allantol
  • glyoxyldiureid
  • glyoxyldiureide
  • glyoxylic diureide
A urea hydantoin that is found in URINE and PLANTS and is used in dermatological preparations.
  • Molecular weight: 158.12
  • Formula: C4H6N4O3
  • CLOGP: -1.91
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 113.32
  • ALOGS: -1.52
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TTK 32
kinase-selectivity-class ACVR2B,AURKC,AXL,CDK16,CDK3,CDK9,GRK2,MAP3K14,MAP3K21,MAPK7,PDK1,SIK2,TEK,TGFBR1 14
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 1060.17 13.97 345 14091 37625 90576386
Chronic sinusitis 469.86 13.97 167 14269 23635 90590376
Paraesthesia oral 388.65 13.97 157 14279 31502 90582509
Vaginal flatulence 352.66 13.97 115 14321 12523 90601488
Proctitis 331.40 13.97 115 14321 15144 90598867
Sedation complication 330.94 13.97 118 14318 16826 90597185
Creatinine renal clearance decreased 325.74 13.97 120 14316 18779 90595232
Female genital tract fistula 321.10 13.97 117 14319 17751 90596260
Radiculopathy 309.74 13.97 115 14321 18390 90595621
Vaginal discharge 307.70 13.97 116 14320 19348 90594663
Procedural pain 307.62 13.97 135 14301 33225 90580786
Constipation 291.75 13.97 286 14150 280109 90333902
Blood calcium decreased 268.12 13.97 119 14317 30063 90583948
Oral candidiasis 240.67 13.97 116 14320 35339 90578672
Orthostatic hypotension 239.84 13.97 122 14314 41705 90572306
Sedation 234.78 13.97 126 14310 48045 90565966
Depressed level of consciousness 213.47 13.97 137 14299 72647 90541364
Colitis 196.12 13.97 128 14308 69814 90544197
Frequent bowel movements 194.25 13.97 118 14318 56817 90557194
Colitis ulcerative 188.07 13.97 118 14318 60148 90553863
Cognitive disorder 187.25 13.97 124 14312 69283 90544728
Haematochezia 177.65 13.97 121 14315 70792 90543219
Rectal haemorrhage 176.62 13.97 128 14308 82616 90531395
Balance disorder 154.21 13.97 126 14310 96954 90517057
Methaemoglobinaemia 151.39 13.97 46 14390 3969 90610042
Renal function test abnormal 143.83 13.97 51 14385 7140 90606871
Creatinine renal clearance increased 142.82 13.97 42 14394 3239 90610772
Therapeutic product effect incomplete 141.32 13.97 164 14272 193732 90420279
Dyspepsia 115.84 13.97 150 14286 198010 90416001
Abdominal pain 108.95 13.97 212 14224 395509 90218502
Weight decreased 97.88 13.97 198 14238 379712 90234299
Erythema 89.12 13.97 143 14293 229103 90384908
Multiple drug therapy 86.74 13.97 35 14401 6974 90607037
Drug ineffective 86.19 13.97 440 13996 1383858 89230153
Anaemia 73.72 13.97 169 14267 352633 90261378
Mobility decreased 66.03 13.97 132 14304 250602 90363409
Hypotension 63.72 13.97 152 14284 325245 90288766
Pain 63.32 13.97 319 14117 996022 89617989
Malaise 57.41 13.97 214 14222 585772 90028239
Pyrexia 54.07 13.97 228 14208 660257 89953754
Toxicity to various agents 53.69 13.97 132 14304 287714 90326297
Fatigue 52.80 13.97 64 14372 1153959 89460052
Infusion related reaction 42.24 13.97 154 14282 416626 90197385
Fall 41.45 13.97 169 14267 481641 90132370
Nausea 39.76 13.97 307 14129 1110009 89504002
Joint swelling 35.42 13.97 18 14418 503282 90110729
Synovitis 33.58 13.97 6 14430 329746 90284265
Glossodynia 32.46 13.97 6 14430 321773 90292238
Peripheral swelling 31.82 13.97 13 14423 413093 90200918
Drug intolerance 31.49 13.97 16 14420 447575 90166436
Pemphigus 31.09 13.97 7 14429 326857 90287154
Hand deformity 31.04 13.97 5 14431 296357 90317654
Swelling 30.98 13.97 14 14422 419044 90194967
Systemic lupus erythematosus 30.21 13.97 10 14426 361886 90252125
Overdose 30.07 13.97 73 14363 157636 90456375
Hepatic enzyme increased 30.05 13.97 10 14426 360726 90253285
Product complaint 29.02 13.97 21 14415 13479 90600532
Drug abuse 28.74 13.97 49 14387 82298 90531713
Product dose omission issue 28.24 13.97 6 14430 291681 90322330
Weight increased 27.85 13.97 16 14420 417911 90196100
Off label use 26.64 13.97 280 14156 1101972 89512039
Pericarditis 25.26 13.97 6 14430 270145 90343866
Abdominal discomfort 24.45 13.97 24 14412 477304 90136707
Rheumatoid arthritis 23.99 13.97 14 14422 362600 90251411
Electrocardiogram PR shortened 23.87 13.97 7 14429 534 90613477
Product use issue 22.89 13.97 12 14424 329907 90284104
Treatment failure 22.69 13.97 10 14426 303918 90310093
Cyanosis 22.29 13.97 21 14415 19434 90594577
Rash 22.06 13.97 60 14376 796040 89817971
Alopecia 21.96 13.97 28 14408 495043 90118968
Arthralgia 21.33 13.97 59 14377 778463 89835548
Discomfort 20.52 13.97 9 14427 274326 90339685
Nasopharyngitis 20.24 13.97 21 14415 407083 90206928
Fibula agenesis 20.09 13.97 4 14432 57 90613954
Spina bifida occulta 20.03 13.97 4 14432 58 90613953
Wound 19.61 13.97 12 14424 302968 90311043
Helicobacter infection 19.39 13.97 6 14430 226844 90387167
Bladder disorder 19.24 13.97 15 14421 10757 90603254
Disinhibition 19.19 13.97 7 14429 1061 90612950
Death 19.04 13.97 27 14409 456524 90157487
Pustule 18.24 13.97 9 14427 2874 90611137
Folliculitis 18.21 13.97 5 14431 204348 90409663
Psoriatic arthropathy 17.87 13.97 7 14429 228328 90385683
Sinusitis 17.85 13.97 17 14419 343071 90270940
Superinfection 17.59 13.97 9 14427 3103 90610908
Dementia 17.02 13.97 20 14416 23841 90590170
General physical health deterioration 16.89 13.97 19 14417 355096 90258915
Irritable bowel syndrome 16.83 13.97 6 14430 207442 90406569
Pruritus 16.38 13.97 39 14397 541486 90072525
Impaired healing 15.54 13.97 9 14427 234190 90379821
Gastrointestinal disorder 15.48 13.97 11 14425 256676 90357335
Duodenal ulcer perforation 15.41 13.97 8 14428 221280 90392731
Contraindicated product administered 15.36 13.97 17 14419 320122 90293889
Maternal exposure during pregnancy 15.30 13.97 21 14415 360042 90253969
Fibromyalgia 15.06 13.97 7 14429 206262 90407749
Arthropathy 14.93 13.97 22 14414 366220 90247791
Intentional product use issue 14.87 13.97 8 14428 216884 90397127
Sleep disorder 14.03 13.97 7 14429 198023 90415988
Completed suicide 14.00 13.97 3 14433 145055 90468956

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 203.96 18.45 89 10852 13367 42597027
Blood phosphorus increased 193.60 18.45 84 10857 12441 42597953
Appendicitis 179.23 18.45 93 10848 20520 42589874
Myasthenia gravis 173.24 18.45 84 10857 16053 42594341
Hyperphosphataemia 158.87 18.45 74 10867 12930 42597464
Ventricular fibrillation 146.37 18.45 93 10848 30030 42580364
Analgesic therapy 138.85 18.45 55 10886 6469 42603925
Drug therapy 129.57 18.45 52 10889 6328 42604066
Sleep disorder therapy 129.06 18.45 53 10888 6841 42603553
Hypophosphataemia 128.26 18.45 75 10866 20870 42589524
Stress 127.13 18.45 99 10842 44113 42566281
Neuralgia 124.13 18.45 79 10862 25568 42584826
Blood uric acid increased 117.75 18.45 64 10877 15483 42594911
Cardiogenic shock 116.12 18.45 86 10855 35554 42574840
Dry mouth 114.00 18.45 89 10852 39790 42570604
Bacterial infection 110.94 18.45 76 10865 27803 42582591
Methaemoglobinaemia 110.16 18.45 45 10896 5729 42604665
Ascites 107.65 18.45 100 10841 56578 42553816
Incorrect route of product administration 100.84 18.45 68 10873 24237 42586157
Abdominal distension 96.55 18.45 105 10836 71630 42538764
Hyponatraemia 95.98 18.45 124 10817 101338 42509056
Multiple organ dysfunction syndrome 90.85 18.45 118 10823 96917 42513477
Activated partial thromboplastin time prolonged 89.64 18.45 54 10887 15849 42594545
Blood cholesterol increased 88.14 18.45 65 10876 26676 42583718
Diabetes mellitus 87.99 18.45 92 10849 59995 42550399
Iron deficiency 85.04 18.45 46 10895 11015 42599379
Blood calcium increased 73.02 18.45 38 10903 8416 42601978
Anticoagulant therapy 71.95 18.45 31 10910 4504 42605890
Swelling 71.48 18.45 79 10862 54806 42555588
Antacid therapy 70.77 18.45 31 10910 4686 42605708
Intentional product misuse 68.66 18.45 82 10859 61818 42548576
Thrombosis 68.30 18.45 86 10855 68425 42541969
Congenital hiatus hernia 65.79 18.45 32 10909 6142 42604252
Chronic obstructive pulmonary disease 64.14 18.45 80 10861 63034 42547360
Somnolence 63.94 18.45 123 10818 140982 42469412
Sleep disorder 62.23 18.45 69 10872 48026 42562368
Drug hypersensitivity 59.64 18.45 98 10843 99291 42511103
Ulcer 58.79 18.45 42 10899 16399 42593995
Bronchopulmonary aspergillosis allergic 58.72 18.45 27 10914 4571 42605823
End stage renal disease 56.24 18.45 41 10900 16517 42593877
Blood test abnormal 55.65 18.45 37 10904 12869 42597525
Abdominal pain 54.45 18.45 138 10803 190333 42420061
General physical health deterioration 53.41 18.45 119 10822 151127 42459267
Sepsis 49.43 18.45 137 10804 199197 42411197
Drug intolerance 47.82 18.45 79 10862 80345 42530049
Total lung capacity decreased 45.70 18.45 21 10920 3549 42606845
Troponin increased 44.83 18.45 38 10903 19024 42591370
Hyperlipidaemia 44.77 18.45 40 10901 21476 42588918
Gout 44.72 18.45 45 10896 28010 42582384
Bacteroides infection 42.07 18.45 18 10923 2569 42607825
Vomiting 42.04 18.45 166 10775 289557 42320837
Pulmonary embolism 40.94 18.45 93 10848 119519 42490875
Injection related reaction 40.12 18.45 12 10929 604 42609790
Pleuritic pain 39.78 18.45 24 10917 7053 42603341
Lung opacity 35.96 18.45 21 10920 5816 42604578
Aortic stenosis 35.13 18.45 24 10917 8721 42601673
Aspiration 34.76 18.45 32 10909 17854 42592540
Breath sounds abnormal 34.53 18.45 27 10914 12066 42598328
Condition aggravated 31.99 18.45 142 10799 260612 42349782
Cardiovascular disorder 30.11 18.45 26 10915 13339 42597055
Micturition urgency 28.55 18.45 24 10917 11874 42598520
Hypercholesterolaemia 26.95 18.45 24 10917 12825 42597569
Benign prostatic hyperplasia 25.15 18.45 29 10912 21023 42589371
Joint injury 24.23 18.45 24 10917 14652 42595742
Lower respiratory tract infection 23.82 18.45 40 10901 41166 42569228
Respiratory symptom 23.80 18.45 21 10920 11085 42599309
Product complaint 23.06 18.45 16 10925 5961 42604433
Oesophageal injury 22.08 18.45 6 10935 213 42610181
Aspartate aminotransferase increased 22.07 18.45 56 10885 77107 42533287
Anaemia 20.84 18.45 133 10808 280145 42330249
Skin reaction 20.66 18.45 16 10925 7051 42603343
Volvulus 20.15 18.45 10 10931 2003 42608391
Blood creatinine increased 19.20 18.45 67 10874 109936 42500458
Arthralgia 18.91 18.45 15 10926 205223 42405171

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Chronic sinusitis 400.21 13.33 164 23873 24920 110540342
Macular degeneration 395.29 13.33 156 23881 21503 110543759
Paraesthesia oral 325.99 13.33 155 23882 33516 110531746
Vaginal flatulence 318.18 13.33 114 23923 12030 110553232
Proctitis 291.71 13.33 117 23920 16810 110548452
Female genital tract fistula 290.99 13.33 116 23921 16403 110548859
Sedation complication 283.63 13.33 120 23917 19735 110545527
Creatinine renal clearance decreased 282.50 13.33 123 23914 21692 110543570
Vaginal discharge 278.53 13.33 115 23922 17793 110547469
Radiculopathy 270.02 13.33 115 23922 19221 110546041
Procedural pain 256.33 13.33 134 23903 35431 110529831
Methaemoglobinaemia 247.48 13.33 88 23949 9080 110556182
Blood calcium decreased 232.78 13.33 126 23911 35719 110529543
Constipation 227.53 13.33 331 23706 357455 110207807
Appendicolith 216.46 13.33 90 23947 14165 110551097
Oral candidiasis 188.96 13.33 119 23918 44641 110520621
Blood phosphorus increased 188.59 13.33 85 23952 16255 110549007
Appendicitis 170.84 13.33 95 23942 28369 110536893
Myasthenia gravis 169.25 13.33 86 23951 21425 110543837
Sedation 169.22 13.33 132 23905 69551 110495711
Orthostatic hypotension 164.14 13.33 127 23910 66122 110499140
Hyperphosphataemia 160.29 13.33 76 23961 16305 110548957
Depressed level of consciousness 150.77 13.33 152 23885 112126 110453136
Analgesic therapy 145.34 13.33 56 23981 7228 110558034
Abdominal pain 138.39 13.33 328 23709 512661 110052601
Ventricular fibrillation 138.23 13.33 95 23942 41218 110524044
Sleep disorder therapy 136.91 13.33 54 23983 7417 110557845
Frequent bowel movements 135.10 13.33 117 23920 71273 110493989
Drug therapy 134.66 13.33 53 23984 7238 110558024
Cognitive disorder 131.49 13.33 126 23911 87385 110477877
Colitis ulcerative 126.99 13.33 117 23920 77246 110488016
Creatinine renal clearance increased 125.82 13.33 42 23995 3583 110561679
Renal function test abnormal 120.88 13.33 52 23985 8894 110556368
Colitis 116.74 13.33 127 23910 102196 110463066
Blood uric acid increased 116.08 13.33 67 23970 21462 110543800
Hypophosphataemia 115.03 13.33 78 23959 33104 110532158
Balance disorder 113.11 13.33 133 23904 116427 110448835
Rectal haemorrhage 108.51 13.33 132 23905 119701 110445561
Haematochezia 107.45 13.33 129 23908 115395 110449867
Bacterial infection 96.42 13.33 80 23957 45956 110519306
Cardiogenic shock 94.63 13.33 87 23950 57251 110508011
Neuralgia 92.81 13.33 80 23957 48398 110516864
Anaemia 92.60 13.33 295 23742 546791 110018471
Ascites 91.86 13.33 107 23930 92701 110472561
Dyspepsia 88.37 13.33 153 23884 190812 110374450
Activated partial thromboplastin time prolonged 85.78 13.33 56 23981 22312 110542950
Therapeutic product effect incomplete 84.24 13.33 164 23873 223641 110341621
Stress 82.57 13.33 108 23929 105240 110460022
Multiple drug therapy 80.91 13.33 38 23999 7976 110557286
Iron deficiency 72.67 13.33 47 23990 18429 110546833
Anticoagulant therapy 71.90 13.33 31 24006 5330 110559932
Antacid therapy 71.22 13.33 31 24006 5453 110559809
Multiple organ dysfunction syndrome 70.75 13.33 122 23915 151588 110413674
Congenital hiatus hernia 70.43 13.33 32 24005 6227 110559035
Diabetes mellitus 68.91 13.33 96 23941 99285 110465977
Hyponatraemia 63.80 13.33 144 23893 217509 110347753
Erythema 63.40 13.33 172 23865 291275 110273987
Abdominal distension 60.67 13.33 124 23913 174979 110390283
Weight decreased 57.25 13.33 227 23810 467830 110097432
Incorrect route of product administration 57.03 13.33 70 23967 63991 110501271
Fatigue 54.91 13.33 114 23923 1215844 109349418
Bronchopulmonary aspergillosis allergic 52.95 13.33 29 24008 8397 110556865
Blood calcium increased 52.25 13.33 38 23999 18002 110547260
Joint swelling 51.68 13.33 16 24021 442829 110122433
Thrombosis 51.45 13.33 88 23949 108574 110456688
End stage renal disease 50.63 13.33 40 23997 21433 110543829
Mobility decreased 46.57 13.33 135 23902 237287 110327975
Peripheral swelling 46.42 13.33 15 24022 404019 110161243
Chronic obstructive pulmonary disease 44.74 13.33 83 23954 109075 110456187
Arthralgia 43.37 13.33 64 23973 779568 109785694
Bacteroides infection 42.86 13.33 18 24019 2901 110562361
Gout 42.74 13.33 46 23991 36520 110528742
Synovitis 42.25 13.33 5 24032 274087 110291175
Pain 41.93 13.33 352 23685 954603 109610659
Treatment failure 40.48 13.33 6 24031 277228 110288034
Somnolence 40.21 13.33 149 23888 297300 110267962
Weight increased 38.02 13.33 22 24015 419622 110145640
Nausea 35.95 13.33 418 23619 1235272 109329990
Troponin increased 35.77 13.33 38 23999 29728 110535534
Ulcer 35.00 13.33 45 23992 43071 110522191
Sepsis 34.67 13.33 152 23885 327194 110238068
Pyrexia 34.18 13.33 321 23716 897944 109667318
Hand deformity 33.64 13.33 4 24033 218502 110346760
Intentional product misuse 33.55 13.33 83 23954 132821 110432441
Blood test abnormal 33.51 13.33 36 24001 28518 110536744
Product use issue 33.35 13.33 13 24024 311682 110253580
Hyperlipidaemia 33.25 13.33 40 23997 35808 110529454
Rheumatoid arthritis 32.89 13.33 12 24025 299601 110265661
Product complaint 32.88 13.33 26 24011 13946 110551316
Total lung capacity decreased 32.75 13.33 20 24017 7094 110558168
Contraindicated product administered 32.71 13.33 7 24030 248260 110317002
Benign prostatic hyperplasia 32.69 13.33 29 24008 18205 110547057
Intentional product use issue 32.64 13.33 7 24030 247899 110317363
Systemic lupus erythematosus 31.86 13.33 8 24029 254330 110310932
Pericarditis 31.39 13.33 5 24032 219109 110346153
Injection related reaction 31.01 13.33 12 24025 1566 110563696
Hepatic enzyme increased 30.25 13.33 16 24021 320876 110244386
Aortic stenosis 30.08 13.33 24 24013 13035 110552227
Glossodynia 29.78 13.33 6 24031 221998 110343264
Infusion related reaction 29.62 13.33 162 23875 381000 110184262
Pulmonary embolism 29.43 13.33 108 23929 214366 110350896
Dry mouth 29.41 13.33 103 23934 199845 110365417
Pemphigus 28.37 13.33 6 24031 214564 110350698
Breath sounds abnormal 28.02 13.33 31 24006 25373 110539889
Pleuritic pain 27.61 13.33 25 24012 16115 110549147
Aspiration 26.58 13.33 33 24004 30500 110534762
Nasopharyngitis 26.46 13.33 28 24009 394333 110170929
Rash 26.32 13.33 91 23946 820873 109744389
Completed suicide 26.10 13.33 10 24027 242371 110322891
Pain in extremity 26.07 13.33 41 23996 487077 110078185
Lung opacity 25.96 13.33 21 24016 11631 110553631
Psoriatic arthropathy 25.01 13.33 6 24031 196755 110368507
Helicobacter infection 24.22 13.33 5 24032 181872 110383390
Hypotension 23.91 13.33 195 23842 523654 110041608
Cardiovascular disorder 23.78 13.33 27 24010 22733 110542529
Folliculitis 23.62 13.33 4 24033 167649 110397613
Sinusitis 23.56 13.33 18 24019 296670 110268592
Aspartate aminotransferase increased 23.18 13.33 82 23955 159854 110405408
Wound 23.13 13.33 11 24026 234426 110330836
Micturition urgency 22.04 13.33 24 24013 19296 110545966
Respiratory symptom 21.45 13.33 21 24016 14924 110550338
Abdominal discomfort 21.21 13.33 33 24004 393825 110171437
Alopecia 21.17 13.33 29 24008 364724 110200538
Oesophageal injury 20.95 13.33 6 24031 307 110564955
Arthropathy 20.91 13.33 19 24018 287503 110277759
Diarrhoea 20.68 13.33 154 23883 1139351 109425911
Fibromyalgia 20.23 13.33 6 24031 170903 110394359
Malaise 20.21 13.33 229 23808 671590 109893672
Hypersensitivity 19.77 13.33 36 24001 403962 110161300
Overdose 19.25 13.33 101 23936 233693 110331569
Irritable bowel syndrome 19.01 13.33 6 24031 164209 110401053
Cyanosis 18.07 13.33 27 24010 29714 110535548
Infection 17.96 13.33 32 24005 362168 110203094
Discomfort 17.08 13.33 13 24024 214694 110350568
Rheumatoid factor positive 16.76 13.33 4 24033 131636 110433626
Blood cholesterol increased 16.73 13.33 82 23955 184703 110380559
Bladder disorder 16.64 13.33 16 24021 11121 110554141
Muscle injury 16.56 13.33 5 24032 140802 110424460
Duodenal ulcer perforation 16.53 13.33 9 24028 177691 110387571
Volvulus 16.48 13.33 10 24027 3508 110561754
Type 2 diabetes mellitus 16.45 13.33 9 24028 177223 110388039
Psoriasis 16.41 13.33 5 24032 139988 110425274
Confusional state 16.34 13.33 50 23987 468630 110096632
Wheezing 16.14 13.33 19 24018 255211 110310051
Ill-defined disorder 16.03 13.33 7 24030 156846 110408416
Impaired healing 15.53 13.33 12 24025 196705 110368557
Night sweats 15.32 13.33 5 24032 133978 110431284
Maternal exposure during pregnancy 15.05 13.33 20 24017 254863 110310399
Paraesthesia 15.04 13.33 23 24014 276498 110288764
Inflammation 14.99 13.33 12 24025 193226 110372036
Arthritis 14.86 13.33 9 24028 167577 110397685
Back pain 14.85 13.33 37 24000 370959 110194303
Osteoarthritis 14.60 13.33 11 24026 182612 110382650
Pustule 13.99 13.33 9 24028 3495 110561767
Sleep disorder due to general medical condition, insomnia type 13.87 13.33 3 24034 105640 110459622
Injury 13.76 13.33 11 24026 177254 110388008
Product dose omission issue 13.75 13.33 31 24006 321751 110243511
Fall 13.57 13.33 195 23842 603287 109961975
Muscle spasms 13.41 13.33 25 24012 278132 110287130
Obesity 13.37 13.33 4 24033 113347 110451915

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis simplex indication 200767005
Skin irritation indication 367466007
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Folliculitis contraindication 13600006 DOID:4409
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Open wound contraindication 125643001
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Porphyria contraindication 418470004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.71 acidic
pKa2 10.76 acidic
pKa3 11.46 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018613 VUID
N0000146926 NUI
D00121 KEGG_DRUG
4018613 VANDF
C0002083 UMLSCUI
CHEBI:15676 CHEBI
2AL PDB_CHEM_ID
CHEMBL593429 ChEMBL_ID
D000481 MESH_DESCRIPTOR_UI
DB11100 DRUGBANK_ID
344S277G0Z UNII
204 PUBCHEM_CID
508 RXNORM
4149 MMSL
72840 MMSL
002009 NDDF
395933009 SNOMEDCT_US
404834008 SNOMEDCT_US
344S277G0Z INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mederma Advanced Scar HUMAN OTC DRUG LABEL 1 0113-4085 GEL 5 mg TOPICAL OTC Monograph Drug 13 sections
Mederma for Kids HUMAN OTC DRUG LABEL 1 0113-4126 GEL 1 g TOPICAL OTC Monograph Drug 13 sections
Cetaphil Baby Soothe and Protect Cream HUMAN OTC DRUG LABEL 1 0299-4103 CREAM 5 mg TOPICAL OTC Monograph Drug 7 sections
Cetaphil Soothing Gel Cream HUMAN OTC DRUG LABEL 1 0299-4105 CREAM 5 mg TOPICAL OTC Monograph Drug 7 sections
Walgreens Advanced Scar Gel HUMAN OTC DRUG LABEL 1 0363-2312 GEL 5 mg TOPICAL OTC Monograph Drug 12 sections
Scar HUMAN OTC DRUG LABEL 1 0363-3131 GEL 0.50 g TOPICAL OTC monograph final 12 sections
Walgreens Advanced Wound Hydrogel HUMAN OTC DRUG LABEL 2 0363-9655 GEL 0.50 mg TOPICAL OTC Monograph Drug 13 sections
ANBESOL COLD SORE THERAPY HUMAN OTC DRUG LABEL 4 0573-0246 OINTMENT 10 mg TOPICAL OTC monograph not final 14 sections
Orajel Cold Sore Moisturelock HUMAN OTC DRUG LABEL 6 10237-761 CREAM 5 mg TOPICAL OTC Monograph Drug 12 sections
TriDerma Genuine Aloe Burn HUMAN OTC DRUG LABEL 1 10738-026 CREAM 1.50 g TOPICAL OTC Monograph Drug 10 sections
Nasal Dryness Relief Gel HUMAN OTC DRUG LABEL 1 10738-051 GEL 0.50 g TOPICAL OTC Monograph Drug 15 sections
TRIDERMA PROTECT AND HEAL NON- GREASY BARRIER HUMAN OTC DRUG LABEL 2 10738-061 CREAM 1.50 g TOPICAL OTC Monograph Drug 11 sections
TriDerma Foot Defense HUMAN OTC DRUG LABEL 1 10738-064 CREAM 15 mg TOPICAL OTC Monograph Drug 13 sections
TriDerma Stubborn Diaper Rash Relief HUMAN OTC DRUG LABEL 2 10738-068 CREAM 1.50 g TOPICAL OTC Monograph Drug 11 sections
TriDerma Aloe Zinc Occlusive HUMAN OTC DRUG LABEL 1 10738-123 CREAM 1.50 g TOPICAL OTC Monograph Drug 11 sections
TriDerma Protect Heal Non Greasy Barrier Cream HUMAN OTC DRUG LABEL 1 10738-161 CREAM 1.50 g TOPICAL OTC Monograph Drug 11 sections
TriDerma Stubborn Diaper Rash Relief HUMAN OTC DRUG LABEL 1 10738-168 CREAM 1.50 g TOPICAL OTC Monograph Drug 14 sections
TriDerma LipSore Relief Cream HUMAN OTC DRUG LABEL 1 10738-920 CREAM 1.50 g TOPICAL OTC Monograph Drug 11 sections
SBS 40 HUMAN OTC DRUG LABEL 1 11084-040 LOTION 0.50 mL TOPICAL OTC monograph final 11 sections
Cool Melon HUMAN OTC DRUG LABEL 1 11084-042 CREAM 0.50 mL TOPICAL OTC monograph final 9 sections
SBS 40 HUMAN OTC DRUG LABEL 1 11084-240 CREAM 5 mg TOPICAL OTC monograph final 11 sections
Sheffield Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11527-725 GEL 5 mg TOPICAL OTC Monograph Drug 12 sections
Target Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11673-725 GEL 5 mg TOPICAL OTC Monograph Drug 12 sections
Scar Care HUMAN OTC DRUG LABEL 1 11673-777 GEL 0.50 g TOPICAL OTC monograph final 11 sections
Rite Aid Scar HUMAN OTC DRUG LABEL 1 11822-1297 GEL 0.50 g TOPICAL OTC Monograph Drug 7 sections
Rite Aid Advanced Scar Gel HUMAN OTC DRUG LABEL 1 11822-8214 GEL 5 mg TOPICAL OTC Monograph Drug 12 sections
SOOTHE Sensitive Skin Treatment HUMAN OTC DRUG LABEL 2 14222-2420 LOTION 0.50 g TOPICAL OTC Monograph Drug 12 sections
Bodyglide anti chafe balm HUMAN OTC DRUG LABEL 1 15197-007 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 8 sections
Chamois Glide HUMAN OTC DRUG LABEL 1 15197-008 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 8 sections
Bodyglide For Her HUMAN OTC DRUG LABEL 1 15197-009 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 8 sections