zinc oxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4240	1314-13-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: zinc oxide	A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock. Molecular weight: 81.38 Formula: OZn CLOGP: LIPINSKI: None HAC: 1 HDO: 0 TPSA: 17.07 ALOGS: ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 16, 2006	FDA	DELCOR ASSET

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	1156.04	9.69	3672	283591	236543	46162256
Pemphigus	947.65	9.69	1277	285986	43997	46354802
Systemic lupus erythematosus	817.83	9.69	1451	285812	63729	46335070
Completed suicide	666.04	9.69	64	287199	145856	46252943
Glossodynia	630.31	9.69	1044	286219	43329	46355470
Hand deformity	467.69	9.69	796	286467	33778	46365021
Maternal exposure during pregnancy	459.35	9.69	1532	285731	101017	46297782
Arthropathy	397.73	9.69	1286	285977	83414	46315385
Toxicity to various agents	387.71	9.69	439	286824	211327	46187472
Alopecia	384.53	9.69	1994	285269	160420	46238379
Joint swelling	355.18	9.69	1983	285280	164090	46234709
Abdominal discomfort	350.25	9.69	1845	285418	149320	46249479
Infusion related reaction	344.22	9.69	1383	285880	99825	46298974
Pain	334.56	9.69	4434	282829	472514	45926285
Death	325.89	9.69	1022	286241	334526	46064273
Arthralgia	315.54	9.69	3528	283735	361075	46037724
Wound	299.73	9.69	751	286512	42051	46356748
Drug abuse	296.70	9.69	25	287238	63383	46335416
Exposure during pregnancy	286.64	9.69	1372	285891	106840	46291959
Synovitis	271.09	9.69	910	286353	60165	46338634
Intentional overdose	256.55	9.69	45	287218	64899	46333900
Contraindicated product administered	240.13	9.69	1052	286211	78895	46319904
Anti-cyclic citrullinated peptide antibody positive	226.82	9.69	416	286847	18729	46380070
Drug interaction	207.25	9.69	604	286659	202490	46196309
Pericarditis	203.53	9.69	453	286810	23474	46375325
Swelling	197.14	9.69	1377	285886	123134	46275665
Rheumatoid factor positive	195.41	9.69	406	286857	20055	46378744
Nasopharyngitis	188.07	9.69	1603	285660	152395	46246404
Overdose	179.30	9.69	218	287045	101761	46297038
C-reactive protein abnormal	179.01	9.69	401	286862	20869	46377930
Hip arthroplasty	173.68	9.69	360	286903	17752	46381047
Suicide attempt	164.84	9.69	66	287197	54970	46343829
Red blood cell sedimentation rate abnormal	159.69	9.69	295	286968	13354	46385445
Musculoskeletal stiffness	157.56	9.69	1088	286175	96905	46301894
Product use issue	156.44	9.69	1058	286205	93586	46305213
Knee arthroplasty	154.00	9.69	404	286859	23261	46375538
Cardiac arrest	152.91	9.69	199	287064	90200	46308599
Injection site erythema	141.44	9.69	862	286401	73565	46325234
Acute kidney injury	134.62	9.69	874	286389	234981	46163818
Sickle cell anaemia with crisis	131.74	9.69	142	287121	3850	46394949
Discomfort	130.94	9.69	602	286661	46068	46352731
Drug hypersensitivity	129.98	9.69	922	286341	242903	46155896
Pregnancy	129.00	9.69	414	286849	26723	46372076
Febrile neutropenia	128.87	9.69	241	287022	94386	46304413
Injection site pain	125.28	9.69	1105	286158	106047	46292752
Device expulsion	113.42	9.69	17	287246	27525	46371274
Injection site pruritus	108.06	9.69	508	286755	39235	46359564
Depressed level of consciousness	106.44	9.69	82	287181	47487	46351312
Drug ineffective	106.23	9.69	5139	282124	672699	45726100
Arthritis	105.13	9.69	825	286438	76491	46322308
Abortion spontaneous	103.10	9.69	536	286727	43110	46355689
Therapeutic product effect decreased	101.32	9.69	861	286402	81740	46317059
Bradycardia	100.18	9.69	158	287105	66140	46332659
Blood pressure fluctuation	99.33	9.69	411	286852	30037	46368762
Psoriatic arthropathy	98.90	9.69	465	286798	35914	46362885
Lactic acidosis	97.78	9.69	43	287220	33866	46364933
Respiratory arrest	92.69	9.69	46	287217	33770	46365029
Hyponatraemia	92.23	9.69	317	286946	101015	46297784
Injection site swelling	90.97	9.69	489	286774	39838	46358961
Malignant neoplasm progression	90.47	9.69	163	287100	64763	46334036
Cardiac failure	89.49	9.69	227	287036	79721	46319078
Injection site reaction	89.49	9.69	552	286711	47297	46351502
Electrocardiogram QT prolonged	86.74	9.69	113	287150	51212	46347587
Disease progression	86.25	9.69	281	286982	91019	46307780
Osteoarthritis	84.40	9.69	662	286601	61363	46337436
Treatment failure	84.26	9.69	910	286353	92177	46306622
Confusional state	83.46	9.69	608	286655	159284	46239515
Anxiety	83.35	9.69	717	286546	181240	46217559
Duodenal ulcer perforation	82.69	9.69	170	287093	8332	46390467
Basal cell carcinoma	78.55	9.69	291	286972	20196	46378603
Helicobacter infection	78.03	9.69	202	287061	11534	46387265
Dyspnoea	77.66	9.69	2500	284763	513048	45885751
Renal failure	74.20	9.69	403	286860	113191	46285608
Drug reaction with eosinophilia and systemic symptoms	74.01	9.69	45	287218	29503	46369296
Sopor	73.52	9.69	16	287247	19812	46378987
Agitation	72.91	9.69	144	287119	55271	46343528
Cardio-respiratory arrest	72.55	9.69	163	287100	59706	46339093
Tremor	72.40	9.69	416	286847	115223	46283576
Intentional self-injury	72.32	9.69	29	287234	24137	46374662
Joint effusion	72.21	9.69	199	287064	11796	46387003
Product quality issue	71.75	9.69	68	287195	35580	46363219
Rhabdomyolysis	70.07	9.69	93	287170	41816	46356983
Caesarean section	69.76	9.69	243	287020	16360	46382439
Disability assessment scale score increased	69.49	9.69	77	287186	2155	46396644
Neutropenia	67.94	9.69	559	286704	142645	46256154
Dizziness	65.69	9.69	1594	285669	338820	46059979
Drug withdrawal syndrome	64.11	9.69	45	287218	27339	46371460
Multiple sclerosis relapse	64	9.69	100	287163	42025	46356774
Sinusitis	63.19	9.69	1136	286127	128632	46270167
Lower respiratory tract infection	62.22	9.69	564	286699	54525	46344274
Somnolence	62.13	9.69	639	286624	155882	46242917
Asthma	61.31	9.69	322	286941	91220	46307579
Joint laxity	59.62	9.69	69	287194	2027	46396772
Impaired healing	59.60	9.69	409	286854	36334	46362465
Psoriasis	59.33	9.69	742	286521	77862	46320937
Constipation	59.18	9.69	736	286527	173361	46225438
Live birth	58.87	9.69	168	287095	10162	46388637
Hepatic enzyme increased	58.75	9.69	765	286498	81022	46317777
Injection site bruising	58.59	9.69	398	286865	35238	46363561
Localised infection	58.08	9.69	295	286968	23506	46375293
Nausea	57.60	9.69	3556	283707	683898	45714901
Hypotension	57.48	9.69	1046	286217	231543	46167256
Red blood cell sedimentation rate increased	56.77	9.69	285	286978	22604	46376195
Blood pressure diastolic abnormal	55.59	9.69	121	287142	6173	46392626
Osteoporosis	54.45	9.69	432	286831	40176	46358623
Premature labour	54.25	9.69	173	287090	11126	46387673
Neoplasm progression	53.58	9.69	51	287212	26632	46372167
Sedation	53.17	9.69	38	287225	22872	46375927
Insomnia	51.36	9.69	710	286553	164214	46234585
Injection site rash	51.21	9.69	213	287050	15600	46383199
Maternal drugs affecting foetus	50.94	9.69	108	287155	5410	46393389
Tachycardia	50.90	9.69	381	286882	99241	46299558
Loss of personal independence in daily activities	50.79	9.69	557	286706	56626	46342173
Rheumatoid nodule	50.73	9.69	146	287117	8874	46389925
Pre-eclampsia	50.50	9.69	135	287128	7859	46390940
Delirium	50.49	9.69	95	287168	37133	46361666
Pulmonary arterial hypertension	50.40	9.69	51	287212	25877	46372922
Drug dependence	50.27	9.69	30	287233	19871	46378928
Oropharyngeal pain	49.65	9.69	685	286578	73483	46325316
Intentional product misuse	49.55	9.69	138	287125	46990	46351809
No adverse event	49.44	9.69	84	287179	34147	46364652
Neck deformity	49.36	9.69	59	287204	1795	46397004
Coma	48.81	9.69	189	287074	58160	46340639
Hypoglycaemia	48.77	9.69	171	287092	54178	46344621
Asthenia	48.72	9.69	1500	285763	309575	46089224
Foetal exposure during pregnancy	48.54	9.69	340	286923	30407	46368392
Hepatic failure	48.26	9.69	82	287181	33334	46365465
Juvenile idiopathic arthritis	47.94	9.69	89	287174	4043	46394756
Serotonin syndrome	47.81	9.69	47	287216	24173	46374626
Cholestasis	46.69	9.69	58	287205	26835	46371964
Gestational diabetes	45.69	9.69	122	287141	7097	46391702
Encephalopathy	45.30	9.69	86	287177	33503	46365296
Musculoskeletal pain	45.06	9.69	643	286620	69485	46329314
Poisoning	44.90	9.69	15	287248	13979	46384820
Condition aggravated	44.82	9.69	1889	285374	243163	46155636
Drug intolerance	43.79	9.69	1200	286063	145849	46252950
Palmar-plantar erythrodysaesthesia syndrome	43.56	9.69	37	287226	20414	46378385
Hyperhidrosis	43.53	9.69	346	286917	88962	46309837
Herpes zoster	43.48	9.69	622	286641	67250	46331549
Renal impairment	43.14	9.69	274	286989	74098	46324701
Blood pressure systolic abnormal	43.08	9.69	101	287162	5416	46393383
Neuropathy peripheral	42.99	9.69	355	286908	90538	46308261
Tuberculosis	42.92	9.69	150	287113	10115	46388684
Foot deformity	42.52	9.69	198	287065	15227	46383572
Pain in extremity	42.45	9.69	1972	285291	256708	46142091
Hepatocellular injury	42.12	9.69	73	287190	29449	46369350
Hyperglycaemia	42.06	9.69	96	287167	34975	46363824
Metabolic acidosis	41.93	9.69	112	287151	38668	46360131
Joint stiffness	41.76	9.69	298	286965	26810	46371989
Therapeutic response decreased	41.46	9.69	427	286836	42718	46356081
Cytomegalovirus infection	40.93	9.69	31	287232	18113	46380686
Diarrhoea	40.45	9.69	2932	284331	556670	45842129
Bone erosion	40.36	9.69	139	287124	9304	46389495
Product use in unapproved indication	40.27	9.69	358	286905	89915	46308884
Vomiting	40.10	9.69	2329	284934	450465	45948334
Plasma cell myeloma	39.87	9.69	140	287123	44338	46354461
Altered state of consciousness	39.86	9.69	51	287212	23297	46375502
Disturbance in attention	39.82	9.69	84	287179	31476	46367323
Premature delivery	39.63	9.69	252	287011	21817	46376982
Blood pressure systolic increased	39.55	9.69	308	286955	28479	46370320
Drug resistance	38.77	9.69	30	287233	17338	46381461
Myalgia	38.62	9.69	529	286734	122559	46276240
Skin ulcer	38.54	9.69	336	286927	32122	46366677
Hallucination	37.91	9.69	168	287095	49783	46349016
Limb deformity	37.76	9.69	74	287189	3502	46395297
Infective pulmonary exacerbation of cystic fibrosis	37.56	9.69	10	287253	10797	46388002
Restlessness	37.44	9.69	62	287201	25462	46373337
Ventricular septal defect	37.29	9.69	79	287184	3955	46394844
Nodule	37.08	9.69	192	287071	15413	46383386
Cardiac failure congestive	37.02	9.69	373	286890	91377	46307422
Emotional distress	36.87	9.69	84	287179	30623	46368176
Hepatic function abnormal	36.77	9.69	100	287163	34321	46364478
Blood pressure diastolic decreased	36.70	9.69	179	287084	14032	46384767
Hyperkalaemia	35.85	9.69	175	287088	50534	46348265
Small for dates baby	35.70	9.69	73	287190	3564	46395235
Fatigue	35.63	9.69	4270	282993	604427	45794372
Influenza	35.49	9.69	758	286505	88512	46310287
Hypoxia	35.45	9.69	181	287082	51657	46347142
Inflammation	35.31	9.69	457	286806	48324	46350475
Osteonecrosis of jaw	35.23	9.69	102	287161	34300	46364499
Diabetic ketoacidosis	35.18	9.69	36	287227	18174	46380625
Malignant melanoma	34.84	9.69	140	287123	10094	46388705
Fibromyalgia	34.62	9.69	360	286903	36103	46362696
Oral herpes	34.56	9.69	221	287042	19169	46379630
Femur fracture	34.53	9.69	364	286899	36633	46362166
Injection site warmth	34.51	9.69	172	287091	13600	46385199
Grip strength decreased	34.47	9.69	124	287139	8482	46390317
Mydriasis	34.41	9.69	11	287252	10542	46388257
Peripheral swelling	34.40	9.69	1242	286021	156829	46241970
Arthritis infective	33.98	9.69	88	287175	5025	46393774
Disorientation	33.90	9.69	115	287148	36803	46361996
Shock	33.04	9.69	52	287211	21793	46377006
Heart rate decreased	32.91	9.69	319	286944	31404	46367395
Smear cervix abnormal	32.78	9.69	57	287206	2459	46396340
Syncope	32.66	9.69	451	286812	104352	46294447
General physical health deterioration	32.33	9.69	509	286754	115260	46283539
Neck mass	32.21	9.69	66	287197	3227	46395572
Ejection fraction decreased	31.86	9.69	38	287225	17899	46380900
Multiple organ dysfunction syndrome	31.82	9.69	187	287076	51523	46347276
Bronchitis	31.57	9.69	865	286398	105114	46293685
Enthesopathy	31.46	9.69	81	287182	4609	46394190
Developmental hip dysplasia	31.20	9.69	39	287224	1244	46397555
Urticaria	31.05	9.69	524	286739	117368	46281431
Weight increased	30.74	9.69	1271	285992	163202	46235597
Joint destruction	30.67	9.69	62	287201	3002	46395797
Blood glucose increased	30.63	9.69	289	286974	71724	46327075
Premature rupture of membranes	30.30	9.69	77	287186	4346	46394453
Blood pressure diastolic increased	30.09	9.69	93	287170	5881	46392918
Blood creatine phosphokinase increased	30.02	9.69	80	287183	27644	46371155
Hypokalaemia	29.92	9.69	372	286891	87652	46311147
Respiratory failure	29.91	9.69	407	286856	94409	46304390
Rash	29.57	9.69	2562	284701	353950	46044849
Seizure	29.54	9.69	556	286707	122498	46276301
Joint injury	29.49	9.69	211	287052	18998	46379801
Dyspnoea exertional	29.30	9.69	185	287078	50104	46348695
Multiple fractures	29.29	9.69	88	287175	5479	46393320
Abnormal behaviour	29.20	9.69	53	287210	21005	46377794
Posterior reversible encephalopathy syndrome	29.18	9.69	30	287233	15111	46383688
Anaphylactic reaction	29.12	9.69	199	287064	52913	46345886
Metastases to bone	28.99	9.69	39	287224	17437	46381362
Mental status changes	28.96	9.69	128	287135	37960	46360839
Loss of consciousness	28.86	9.69	480	286783	107758	46291041
Fluid retention	28.61	9.69	190	287073	50856	46347943
Postoperative wound infection	28.42	9.69	118	287145	8635	46390164
Swollen joint count increased	28.23	9.69	52	287211	2348	46396451
Pulmonary embolism	28.15	9.69	484	286779	108101	46290698
Depression	28.12	9.69	814	286449	169290	46229509
Tenderness	28.02	9.69	189	287074	16692	46382107
Joint range of motion decreased	27.96	9.69	174	287089	14950	46383849
Skin papilloma	27.89	9.69	72	287191	4104	46394695
Tenosynovitis stenosans	27.84	9.69	46	287217	1903	46396896
Speech disorder	27.83	9.69	121	287142	36046	46362753
Rheumatic fever	27.83	9.69	57	287206	2786	46396013
Decreased appetite	27.59	9.69	946	286317	192890	46205909
Hypothermia	27.25	9.69	21	287242	12162	46386637
Respiratory depression	27.23	9.69	19	287244	11581	46387218
Synovial cyst	27.04	9.69	103	287160	7243	46391556
Feeling abnormal	26.74	9.69	576	286687	124484	46274315
Cellulitis	26.71	9.69	593	286670	69695	46329104
Gastroenteritis viral	26.65	9.69	197	287066	17922	46380877
Gamma-glutamyltransferase increased	26.41	9.69	103	287160	31637	46367162
Unresponsive to stimuli	26.40	9.69	105	287158	32069	46366730
Schizophrenia	26.10	9.69	10	287253	8558	46390241
Ventricular tachycardia	26.03	9.69	40	287223	16927	46381872
Drug level increased	25.94	9.69	46	287217	18395	46380404
Thrombocytopenia	25.92	9.69	587	286676	125994	46272805
Muscle spasms	25.75	9.69	569	286694	122544	46276255
Neutrophil count decreased	25.69	9.69	159	287104	43267	46355532
Polyhydramnios	25.67	9.69	45	287218	1954	46396845
Cognitive disorder	25.66	9.69	128	287135	36755	46362044
Cerebral haemorrhage	25.62	9.69	89	287174	28282	46370517
Skin cancer	25.62	9.69	115	287148	8708	46390091
Acute generalised exanthematous pustulosis	25.46	9.69	13	287250	9392	46389407
Placental disorder	25.36	9.69	37	287226	1372	46397427
Disseminated intravascular coagulation	25.33	9.69	49	287214	18956	46379843
Contusion	25.19	9.69	711	286552	86776	46312023
Myocardial infarction	25.19	9.69	435	286828	97093	46301706
Pulmonary tuberculosis	25.09	9.69	75	287188	4656	46394143
Latent tuberculosis	25.01	9.69	44	287219	1916	46396883
Suicidal ideation	24.96	9.69	224	287039	56158	46342641
Blood pressure decreased	24.91	9.69	228	287035	56931	46341868
Torsade de pointes	24.67	9.69	23	287240	12131	46386668
Surgery	24.46	9.69	278	286985	28507	46370292
Product administration error	24.31	9.69	53	287210	19628	46379171
Ventricular fibrillation	24.24	9.69	21	287242	11475	46387324
Fracture	24.18	9.69	179	287084	16292	46382507
Disability	24.09	9.69	125	287138	10042	46388757
Angioedema	23.82	9.69	143	287120	39199	46359600
Polyarthritis	23.48	9.69	91	287172	6451	46392348
Extrapyramidal disorder	23.26	9.69	21	287242	11247	46387552
Psychotic disorder	23.21	9.69	67	287196	22554	46376245
Foetal death	23.20	9.69	111	287152	8632	46390167
Anaphylactic shock	23.11	9.69	57	287206	20217	46378582
Synovial fluid analysis	23.08	9.69	35	287228	1344	46397455
Injection site haemorrhage	22.85	9.69	211	287052	20498	46378301
Blood creatinine increased	22.66	9.69	332	286931	76071	46322728
Squamous cell carcinoma	22.65	9.69	102	287161	7734	46391065
Febrile bone marrow aplasia	22.65	9.69	7	287256	6855	46391944
Neuroleptic malignant syndrome	22.63	9.69	21	287242	11101	46387698
Immune reconstitution inflammatory syndrome	22.53	9.69	4	287259	5721	46393078
Metastases to liver	22.37	9.69	55	287208	19530	46379269
Dysarthria	22.33	9.69	137	287126	37361	46361438
Acute hepatic failure	22.30	9.69	35	287228	14686	46384113
Mouth ulceration	22.29	9.69	258	287005	26574	46372225
Cystitis	22.04	9.69	374	286889	41867	46356932
Pancytopenia	21.97	9.69	682	286581	84376	46314423
Anaemia	21.96	9.69	1319	285944	254460	46144339
Injection site haematoma	21.92	9.69	85	287178	6027	46392772
Acute chest syndrome	21.90	9.69	22	287241	548	46398251
Hypersensitivity	21.90	9.69	1133	286130	149188	46249611
Akathisia	21.89	9.69	10	287253	7704	46391095
Atrial septal defect	21.86	9.69	87	287176	6245	46392554
Body height below normal	21.83	9.69	40	287223	1799	46397000
Vertigo	21.65	9.69	210	287053	51838	46346961
Memory impairment	21.59	9.69	340	286923	76997	46321802
Brain oedema	21.57	9.69	27	287236	12451	46386348
Antinuclear antibody positive	21.45	9.69	86	287177	6194	46392605
Blood alkaline phosphatase increased	21.42	9.69	149	287114	39460	46359339
Neurotoxicity	21.37	9.69	32	287231	13685	46385114
Blood bilirubin increased	21.36	9.69	123	287140	34061	46364738
Immunodeficiency	21.31	9.69	146	287117	12960	46385839
Chest discomfort	21.30	9.69	409	286854	89860	46308939
Nightmare	21.09	9.69	44	287219	16554	46382245
Inappropriate antidiuretic hormone secretion	20.92	9.69	34	287229	14068	46384731
Accidental overdose	20.91	9.69	59	287204	20007	46378792
Loose body in joint	20.88	9.69	29	287234	1027	46397772
Gestational hypertension	20.85	9.69	43	287220	2112	46396687
Complication of device insertion	20.47	9.69	3	287260	4941	46393858
Immunosuppression	20.47	9.69	96	287167	7404	46391395
Diabetes mellitus inadequate control	20.42	9.69	31	287232	13183	46385616
Arrhythmia	20.38	9.69	128	287135	34713	46364086
Clear cell renal cell carcinoma	20.17	9.69	28	287235	991	46397808
Jaundice	20.12	9.69	100	287163	28745	46370054
Ascites	20.09	9.69	137	287126	36447	46362352
Hospitalisation	20.01	9.69	272	286991	63113	46335686
Respiratory disorder	20.00	9.69	93	287170	27207	46371592
Aspartate aminotransferase increased	20.00	9.69	352	286911	78348	46320451
Atrioventricular block complete	19.97	9.69	11	287252	7616	46391183
Cushingoid	19.97	9.69	84	287179	6182	46392617
Blood pressure increased	19.95	9.69	962	286301	125704	46273095
Breast feeding	19.91	9.69	26	287237	867	46397932
Infection	19.88	9.69	1009	286254	132583	46266216
Vision blurred	19.79	9.69	358	286905	79350	46319449
Transplant rejection	19.67	9.69	18	287245	9578	46389221
Dysgeusia	19.66	9.69	157	287106	40334	46358465
Fear	19.61	9.69	44	287219	16128	46382671
Congenital arterial malformation	19.58	9.69	17	287246	350	46398449
Muscle spasticity	19.52	9.69	25	287238	11415	46387384
Bradyphrenia	19.43	9.69	7	287256	6223	46392576
Cytokine release syndrome	19.40	9.69	7	287256	6216	46392583
Polyneuropathy	19.30	9.69	26	287237	11618	46387181
Deep vein thrombosis	19.27	9.69	360	286903	79413	46319386
Balance disorder	19.26	9.69	280	286983	64241	46334558
Scleritis	19.23	9.69	50	287213	2862	46395937
Haemoglobin decreased	19.20	9.69	974	286289	127975	46270824
Injection site irritation	19.11	9.69	64	287199	4223	46394576
Multiple sclerosis	19.04	9.69	83	287180	24708	46374091
Laryngitis	19.02	9.69	110	287153	9206	46389593
Wheelchair user	18.91	9.69	61	287202	3947	46394852
Pulmonary fibrosis	18.89	9.69	198	287065	19894	46378905
Spinal stenosis	18.80	9.69	137	287126	12406	46386393
Respiratory distress	18.80	9.69	117	287146	31799	46367000
Crying	18.64	9.69	67	287196	21074	46377725
Fluid overload	18.54	9.69	95	287168	27090	46371709
Pain in jaw	18.53	9.69	149	287114	38223	46360576
Antibody test positive	18.42	9.69	41	287222	2124	46396675
Asphyxia	18.37	9.69	5	287258	5321	46393478
Wheezing	18.37	9.69	225	287038	53161	46345638
Arthritis bacterial	18.36	9.69	77	287186	5659	46393140
Oedema	18.34	9.69	296	286967	66775	46332024
Joint noise	18.32	9.69	52	287211	3135	46395664
Tooth infection	18.31	9.69	134	287129	12152	46386647
Palpitations	18.31	9.69	446	286817	94813	46303986
Dry eye	18.27	9.69	275	286988	30047	46368752
Poor venous access	18.22	9.69	100	287163	8208	46390591
Synovial disorder	17.98	9.69	24	287239	818	46397981
C-reactive protein increased	17.94	9.69	480	286783	58110	46340689
Agranulocytosis	17.82	9.69	73	287190	22112	46376687
Serum ferritin increased	17.77	9.69	72	287191	5211	46393588
Bone disorder	17.71	9.69	195	287068	19838	46378961
Stillbirth	17.66	9.69	83	287180	6408	46392391
Leukopenia	17.58	9.69	305	286958	68038	46330761
Ischaemic stroke	17.55	9.69	49	287214	16673	46382126
Bone pain	17.54	9.69	194	287069	46696	46352103
Injection site urticaria	17.54	9.69	130	287133	11837	46386962
Exomphalos	17.48	9.69	19	287244	520	46398279
Hypomania	17.41	9.69	3	287260	4385	46394414
Human antichimeric antibody positive	17.38	9.69	31	287232	1365	46397434
Device dislocation	17.35	9.69	72	287191	21730	46377069
Bronchospasm	17.25	9.69	45	287218	15662	46383137
Talipes	17.20	9.69	31	287232	1376	46397423
Dyskinesia	17.06	9.69	106	287157	28819	46369980
Diverticulitis	17.04	9.69	292	286971	32747	46366052
Withdrawal syndrome	16.98	9.69	56	287207	18078	46380721
Status epilepticus	16.98	9.69	38	287225	13941	46384858
Chronic kidney disease	16.96	9.69	165	287098	40706	46358093
Cervical incompetence	16.87	9.69	20	287243	603	46398196
Post procedural infection	16.86	9.69	91	287172	7422	46391377
Cerebrovascular accident	16.81	9.69	483	286780	100556	46298243
Premature baby	16.80	9.69	178	287085	17934	46380865
Dehydration	16.80	9.69	806	286457	158734	46240065
Coagulopathy	16.73	9.69	58	287205	18441	46380358
Cholestasis of pregnancy	16.69	9.69	27	287236	1097	46397702
Pharyngitis streptococcal	16.65	9.69	99	287164	8369	46390430
Irritability	16.59	9.69	107	287156	28839	46369960
Graft versus host disease	16.54	9.69	10	287253	6578	46392221
Thrombotic microangiopathy	16.53	9.69	16	287247	8290	46390509
Injury	16.53	9.69	182	287081	43845	46354954
Alanine aminotransferase increased	16.49	9.69	416	286847	88035	46310764
Bone density abnormal	16.46	9.69	49	287214	3035	46395764
Toxic skin eruption	16.45	9.69	32	287231	12355	46386444
Product adhesion issue	16.45	9.69	5	287258	4950	46393849
Haemorrhage	16.42	9.69	238	287025	54631	46344168
White blood cell count decreased	16.35	9.69	546	286717	111685	46287114
Skin laceration	16.31	9.69	180	287083	18322	46380477
Eosinophilia	16.22	9.69	62	287201	19155	46379644
Anhedonia	16.21	9.69	24	287239	10311	46388488
Substance abuse	16.20	9.69	3	287260	4164	46394635
Tenosynovitis	16.18	9.69	90	287173	7425	46391374
Foot fracture	16.14	9.69	188	287075	19394	46379405
Bursitis	16.13	9.69	190	287073	19652	46379147
Joint dislocation	16.10	9.69	121	287142	11065	46387734
Knee operation	16.06	9.69	65	287198	4701	46394098
Paralysis	16.00	9.69	18	287245	8703	46390096
Rotator cuff repair	15.98	9.69	31	287232	1456	46397343
Hallucination, auditory	15.89	9.69	26	287237	10730	46388069
Blood iron increased	15.86	9.69	29	287234	1302	46397497
Foetal distress syndrome	15.82	9.69	28	287235	1225	46397574
Pancreatitis acute	15.80	9.69	89	287174	24783	46374016
Injection site extravasation	15.79	9.69	83	287180	6702	46392097
Aggression	15.78	9.69	79	287184	22665	46376134
Metastases to central nervous system	15.78	9.69	28	287235	11193	46387606
Hiatus hernia	15.66	9.69	177	287086	18125	46380674
Maternal exposure during breast feeding	15.54	9.69	45	287218	2744	46396055
Dactylitis	15.51	9.69	27	287236	1166	46397633
Miosis	15.50	9.69	11	287252	6646	46392153
Stress cardiomyopathy	15.48	9.69	15	287248	7769	46391030
Acute graft versus host disease	15.46	9.69	3	287260	4027	46394772
Pyrexia	15.42	9.69	1895	285368	346907	46051892
Cytopenia	15.42	9.69	15	287248	7753	46391046
Face oedema	15.40	9.69	63	287200	19090	46379709
Psychomotor hyperactivity	15.39	9.69	22	287241	9591	46389208
Device use error	15.36	9.69	6	287257	5075	46393724
Mania	15.31	9.69	27	287236	10819	46387980
Device difficult to use	15.26	9.69	16	287247	7988	46390811
Carpal tunnel syndrome	15.25	9.69	157	287106	15702	46383097
Melaena	15.25	9.69	104	287159	27668	46371131
Joint lock	15.18	9.69	37	287226	2034	46396765
Haemorrhage in pregnancy	15.18	9.69	32	287231	1596	46397203
Second primary malignancy	15.17	9.69	11	287252	6573	46392226
Breast cancer metastatic	15.17	9.69	39	287224	13639	46385160
Obstructive airways disorder	15.06	9.69	38	287225	13374	46385425
Ketoacidosis	15.06	9.69	3	287260	3952	46394847
Eye infection	15.06	9.69	102	287161	9021	46389778
Fracture delayed union	14.96	9.69	38	287225	2144	46396655
Atrioventricular block	14.90	9.69	12	287251	6799	46392000
Erythema multiforme	14.77	9.69	23	287240	9681	46389118
Induced labour	14.64	9.69	23	287240	911	46397888
Acute respiratory failure	14.60	9.69	112	287151	29026	46369773
Pleuritic pain	14.60	9.69	78	287185	6338	46392461
Acute myeloid leukaemia	14.58	9.69	49	287214	15729	46383070
Tardive dyskinesia	14.47	9.69	15	287248	7528	46391271
Off label use	14.47	9.69	2083	285180	377758	46021041
Viral infection	14.45	9.69	264	286999	29971	46368828
Sickle cell anaemia	14.40	9.69	18	287245	574	46398225
Lupus-like syndrome	14.35	9.69	90	287173	7754	46391045
Joint warmth	14.34	9.69	27	287236	1240	46397559
Ingrown hair	14.32	9.69	16	287247	452	46398347
Platelet count decreased	14.25	9.69	488	286775	99536	46299263
Maternal exposure before pregnancy	14.23	9.69	60	287203	4421	46394378
Cyst	14.23	9.69	125	287138	11975	46386824
Lymphoma	14.04	9.69	106	287157	9707	46389092
Body temperature decreased	13.99	9.69	135	287128	13274	46385525
Lymphadenectomy	13.96	9.69	22	287241	874	46397925
Lung neoplasm malignant	13.80	9.69	151	287112	15338	46383461
Injection site induration	13.74	9.69	91	287172	7988	46390811
Tendon disorder	13.68	9.69	64	287199	4931	46393868
Glycosylated haemoglobin increased	13.67	9.69	29	287234	10847	46387952
Myoclonus	13.66	9.69	44	287219	14308	46384491
Abortion missed	13.63	9.69	30	287233	1542	46397257
Weight decreased	13.43	9.69	1488	285775	209361	46189438
Pulmonary hypertension	13.42	9.69	149	287114	35844	46362955
Sedation complication	13.39	9.69	3	287260	3642	46395157
Red blood cell sedimentation rate	13.35	9.69	32	287231	1741	46397058
Hypomagnesaemia	13.30	9.69	81	287182	22129	46376670
Atrial fibrillation	13.26	9.69	512	286751	103078	46295721
Tumour lysis syndrome	13.21	9.69	15	287248	7221	46391578
Cholecystitis chronic	13.20	9.69	28	287235	10471	46388328
Drug ineffective for unapproved indication	13.19	9.69	54	287209	16359	46382440
Pulmonary oedema	13.17	9.69	228	287035	50877	46347922
Pancreatitis	13.14	9.69	189	287074	43438	46355361
Cardiogenic shock	13.11	9.69	54	287209	16330	46382469
Incorrect route of product administration	13.10	9.69	54	287209	16329	46382470
Panic attack	13.10	9.69	72	287191	20170	46378629
Cerebral infarction	13.08	9.69	87	287176	23279	46375520
Autism spectrum disorder	13.06	9.69	17	287246	565	46398234
Foetal anticonvulsant syndrome	12.95	9.69	15	287248	441	46398358
Anterior chamber cleavage syndrome	12.92	9.69	10	287253	174	46398625
Parkinsonism	12.92	9.69	18	287245	7930	46390869
Wound infection pseudomonas	12.88	9.69	28	287235	1427	46397372
Ear infection	12.83	9.69	206	287057	22807	46375992
Limb injury	12.78	9.69	177	287086	18997	46379802
Chest pain	12.78	9.69	923	286340	175401	46223398
Skin infection	12.75	9.69	116	287147	11223	46387576
Upper respiratory tract infection	12.75	9.69	495	286768	63061	46335738
Orthostatic hypotension	12.73	9.69	94	287169	24564	46374235
Wrong technique in product usage process	12.71	9.69	247	287016	54175	46344624
Myopathy	12.63	9.69	22	287241	8859	46389940
Ulcer	12.61	9.69	163	287100	17229	46381570
Post transplant lymphoproliferative disorder	12.61	9.69	4	287259	3852	46394947
Shock haemorrhagic	12.60	9.69	21	287242	8603	46390196
Crohn's disease	12.58	9.69	78	287185	6693	46392106
Lymphatic fistula	12.56	9.69	21	287242	877	46397922
Hypertransaminasaemia	12.56	9.69	3	287260	3485	46395314
Lung neoplasm	12.53	9.69	69	287194	5671	46393128
Uterine contractions during pregnancy	12.52	9.69	16	287247	522	46398277
Rhinorrhoea	12.52	9.69	383	286880	47282	46351517
Crystal nephropathy	12.50	9.69	20	287243	805	46397994
Forceps delivery	12.50	9.69	10	287253	183	46398616
Pemphigoid	12.49	9.69	10	287253	5681	46393118
Human anti-human antibody test	12.46	9.69	13	287250	339	46398460
Cardiac failure acute	12.44	9.69	19	287244	8059	46390740
Foetal growth restriction	12.42	9.69	76	287187	6491	46392308
Femoral hernia incarcerated	12.38	9.69	21	287242	888	46397911
Renal injury	12.37	9.69	25	287238	9516	46389283
Proteinuria	12.36	9.69	56	287207	16497	46382302
Placental insufficiency	12.23	9.69	26	287237	1305	46397494
Labyrinthitis	12.13	9.69	34	287229	2035	46396764
Hemiparesis	12.12	9.69	73	287190	19996	46378803
Pancreatic steatosis	12.11	9.69	22	287241	983	46397816
Hyperuricaemia	12.07	9.69	7	287256	4710	46394089
Vacuum extractor delivery	12.05	9.69	9	287254	148	46398651
Renal mass	12.01	9.69	31	287232	1767	46397032
Nail injury	12.00	9.69	14	287249	415	46398384
Mass	12.00	9.69	117	287146	11536	46387263
Haematotoxicity	11.98	9.69	15	287248	6918	46391881
Hyperlipidaemia	11.96	9.69	66	287197	18473	46380326
Transplant dysfunction	11.91	9.69	7	287256	4675	46394124
Endodontic procedure	11.89	9.69	38	287225	2447	46396352
Dysmorphism	11.84	9.69	32	287231	1875	46396924
Vascular rupture	11.83	9.69	25	287238	1249	46397550
Aspergillus infection	11.81	9.69	15	287248	6875	46391924
Flushing	11.74	9.69	305	286958	64309	46334490
Tonsillitis	11.74	9.69	61	287202	4903	46393896
Intervertebral disc degeneration	11.72	9.69	129	287134	13123	46385676
Normal newborn	11.70	9.69	70	287193	5931	46392868
Myofascial pain syndrome	11.69	9.69	32	287231	1889	46396910
Pathogen resistance	11.68	9.69	12	287251	6048	46392751
Frequent bowel movements	11.65	9.69	124	287139	12508	46386291
Abdominal distension	11.61	9.69	353	286910	72998	46325801
Subdural haematoma	11.58	9.69	41	287222	12956	46385843
Inflammatory pain	11.58	9.69	17	287246	634	46398165
Drug-induced liver injury	11.57	9.69	100	287163	25268	46373531
Genital haemorrhage	11.57	9.69	14	287249	6552	46392247
Haemophagocytic lymphohistiocytosis	11.56	9.69	21	287242	8321	46390478
Acidosis	11.53	9.69	33	287230	11141	46387658
Colitis microscopic	11.53	9.69	14	287249	6542	46392257
Ankylosing spondylitis	11.52	9.69	76	287187	6661	46392138
Pleural effusion	11.51	9.69	406	286857	82546	46316253
Metastases to lung	11.48	9.69	31	287232	10665	46388134
Neonatal respiratory distress syndrome	11.45	9.69	38	287225	2495	46396304
Haemorrhage intracranial	11.43	9.69	40	287223	12684	46386115
Bone marrow failure	11.39	9.69	122	287141	29547	46369252
Mycobacterium tuberculosis complex test positive	11.37	9.69	28	287235	1550	46397249
Hallucination, visual	11.33	9.69	64	287199	17809	46380990
Disseminated tuberculosis	11.32	9.69	40	287223	2712	46396087
Oliguria	11.31	9.69	23	287240	8736	46390063
Photophobia	11.27	9.69	138	287125	14406	46384393
Haematocrit decreased	11.25	9.69	289	286974	34768	46364031
Drug abuser	11.22	9.69	3	287260	3230	46395569
Myocarditis	11.16	9.69	19	287244	7720	46391079
Abortion threatened	11.16	9.69	16	287247	584	46398215
Wound infection	11.15	9.69	105	287158	10254	46388545
Cartilage injury	11.15	9.69	28	287235	1569	46397230
Large for dates baby	11.14	9.69	14	287249	449	46398350
Carcinoma in situ of skin	11.12	9.69	10	287253	216	46398583
Dysphagia	11.05	9.69	377	286886	76935	46321864
Congenital hydronephrosis	11.02	9.69	13	287250	390	46398409
Mood altered	10.96	9.69	42	287221	12965	46385834
Failed induction of labour	10.91	9.69	12	287251	333	46398466
International normalised ratio increased	10.88	9.69	213	287050	46670	46352129
Delusion	10.86	9.69	34	287229	11154	46387645
Incorrect product administration duration	10.86	9.69	27	287236	9550	46389249
Aortic valve stenosis	10.84	9.69	43	287220	3081	46395718
Stress at work	10.83	9.69	21	287242	986	46397813
Oligohydramnios	10.82	9.69	64	287199	5401	46393398
Infusion site erythema	10.81	9.69	19	287244	7623	46391176
Decreased insulin requirement	10.74	9.69	8	287255	131	46398668
Catheter site pain	10.70	9.69	5	287258	3801	46394998
Arthropod bite	10.67	9.69	67	287196	5774	46393025
Unevaluable event	10.65	9.69	210	287053	45965	46352834
Joint arthroplasty	10.62	9.69	32	287231	1995	46396804
Nervousness	10.57	9.69	118	287145	28357	46370442
Stevens-Johnson syndrome	10.55	9.69	92	287171	23205	46375594
Complication associated with device	10.50	9.69	54	287209	15387	46383412
Sinus tachycardia	10.48	9.69	84	287179	21565	46377234
Device breakage	10.47	9.69	28	287235	9664	46389135
Tubulointerstitial nephritis	10.47	9.69	51	287212	14737	46384062
Kidney infection	10.40	9.69	153	287110	16636	46382163
Ill-defined disorder	10.40	9.69	227	287036	26600	46372199
Nodal osteoarthritis	10.36	9.69	18	287245	776	46398023
Bowen's disease	10.33	9.69	10	287253	238	46398561
Infusion site pain	10.32	9.69	30	287233	10077	46388722
Muscular weakness	10.26	9.69	461	286802	91383	46307416
Ileus paralytic	10.26	9.69	7	287256	4316	46394483
Inflammatory bowel disease	10.24	9.69	43	287220	3162	46395637
Chondropathy	10.23	9.69	31	287232	1939	46396860
Patent ductus arteriosus	10.23	9.69	49	287214	3813	46394986
Tuberculin test positive	10.15	9.69	41	287222	2963	46395836
Cold type haemolytic anaemia	10.14	9.69	9	287254	191	46398608
Product prescribing error	10.07	9.69	77	287186	19970	46378829
Rheumatoid lung	10.03	9.69	28	287235	1672	46397127
Impaired quality of life	9.98	9.69	43	287220	3199	46395600
Dermatitis allergic	9.94	9.69	120	287143	12483	46386316
Threatened labour	9.92	9.69	18	287245	803	46397996
Bundle branch block right	9.92	9.69	9	287254	4810	46393989
Therapy change	9.90	9.69	10	287253	5080	46393719
Bundle branch block left	9.90	9.69	15	287248	6384	46392415
Respiratory tract infection	9.89	9.69	248	287015	29724	46369075
Complication of pregnancy	9.89	9.69	14	287249	505	46398294
Tachypnoea	9.87	9.69	50	287213	14301	46384498
Respiration abnormal	9.85	9.69	8	287255	4513	46394286
Fear of injection	9.84	9.69	51	287212	4096	46394703
Intestinal stenosis	9.82	9.69	36	287227	2485	46396314
Pregnancy with contraceptive device	9.77	9.69	8	287255	4495	46394304
Cyst rupture	9.74	9.69	13	287250	443	46398356
Conjunctivitis	9.73	9.69	141	287122	15283	46383516
Gastroenteritis	9.73	9.69	206	287057	24013	46374786
Dystonia	9.71	9.69	36	287227	11221	46387578
Delivery	9.70	9.69	16	287247	661	46398138

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	463.29	9.92	700	122562	40497	29788719
Drug abuse	289.51	9.92	11	123251	82061	29747155
Foetal exposure during pregnancy	227.28	9.92	482	122780	36389	29792827
Arthralgia	204.30	9.92	1099	122163	134692	29694524
Completed suicide	200.90	9.92	79	123183	99413	29729803
Toxicity to various agents	189.79	9.92	272	122990	176911	29652305
Psoriatic arthropathy	126.12	9.92	230	123032	15531	29813685
Sickle cell anaemia with crisis	103.52	9.92	83	123179	2319	29826897
Joint swelling	103.48	9.92	425	122837	46521	29782695
Premature baby	95.70	9.92	212	123050	16479	29812737
Drug interaction	92.29	9.92	465	122797	199103	29630113
Exposure during pregnancy	86.91	9.92	145	123117	9116	29820100
Intentional overdose	81.92	9.92	34	123228	41447	29787769
Neonatal respiratory distress syndrome	74.12	9.92	87	123175	3925	29825291
Tenosynovitis	73.02	9.92	81	123181	3434	29825782
Atrial septal defect	69.79	9.92	110	123152	6591	29822625
Overdose	69.73	9.92	152	123110	84185	29745031
Enthesopathy	67.44	9.92	71	123191	2835	29826381
Nasopharyngitis	65.66	9.92	441	122821	58408	29770808
Blood pressure fluctuation	64.45	9.92	188	123074	17315	29811901
Death	61.23	9.92	1069	122193	356214	29473002
Maternal drugs affecting foetus	60.32	9.92	81	123181	4192	29825024
Musculoskeletal stiffness	56.22	9.92	294	122968	35587	29793629
Acute kidney injury	55.35	9.92	794	122468	273048	29556168
Suicide attempt	55.32	9.92	42	123220	36655	29792561
Hypospadias	54.39	9.92	61	123201	2618	29826598
Synovitis	53.55	9.92	122	123140	9661	29819555
Small for dates baby	48.67	9.92	63	123199	3145	29826071
Psoriasis	48.28	9.92	320	122942	42186	29787030
Maternal exposure during pregnancy	48.09	9.92	69	123193	3802	29825414
Tongue disorder	47.88	9.92	73	123189	4249	29824967
Low birth weight baby	47.75	9.92	88	123174	5988	29823228
Maternal exposure during breast feeding	47.32	9.92	45	123217	1587	29827629
Ventricular septal defect	46.95	9.92	65	123197	3464	29825752
Dysmorphism	46.31	9.92	49	123213	1968	29827248
C-reactive protein abnormal	45.21	9.92	82	123180	5511	29823705
Hypoglycaemia neonatal	44.67	9.92	43	123219	1540	29827676
Infusion related reaction	44.64	9.92	303	122959	40261	29788955
Haemoglobin decreased	43.05	9.92	684	122578	113414	29715802
Pain	42.78	9.92	970	122292	171671	29657545
Drug reaction with eosinophilia and systemic symptoms	42.43	9.92	33	123229	28455	29800761
Serotonin syndrome	41.73	9.92	11	123251	17880	29811336
Pulmonary fibrosis	41.63	9.92	152	123110	15738	29813478
Cryptorchism	40.76	9.92	42	123220	1635	29827581
Arthritis	40.35	9.92	203	123059	24198	29805018
Drug intolerance	39.96	9.92	321	122941	44970	29784246
Intentional product misuse	39.24	9.92	51	123211	34616	29794600
Lower respiratory tract infection	39.19	9.92	215	123047	26499	29802717
Pancytopenia	37.99	9.92	525	122737	84527	29744689
Hepatic function abnormal	37.70	9.92	72	123190	41873	29787343
Basal cell carcinoma	37.39	9.92	148	123114	15920	29813296
Drug resistance	37.39	9.92	18	123244	20115	29809101
Coma	35.86	9.92	70	123192	40379	29788837
Syndactyly	35.03	9.92	27	123235	711	29828505
Rhabdomyolysis	34.79	9.92	139	123123	63441	29765775
Blood pressure systolic increased	34.22	9.92	138	123124	14972	29814244
Exposure via breast milk	34.00	9.92	37	123225	1535	29827681
Arthropathy	33.96	9.92	172	123090	20555	29808661
Osteoarthritis	33.46	9.92	157	123105	18192	29811024
Product use in unapproved indication	33.23	9.92	173	123089	73520	29755696
Large for dates baby	33.17	9.92	28	123234	842	29828374
Drug withdrawal syndrome	32.05	9.92	21	123241	19788	29809428
Foetal anticonvulsant syndrome	31.78	9.92	26	123236	748	29828468
Alanine aminotransferase abnormal	30.10	9.92	45	123217	2574	29826642
Angioedema	30.05	9.92	60	123202	34324	29794892
Loss of personal independence in daily activities	30.05	9.92	171	123091	21364	29807852
Bradycardia	30.01	9.92	153	123109	65373	29763843
Renal failure	29.58	9.92	364	122898	128602	29700614
Blood pressure increased	28.93	9.92	436	122826	71492	29757724
Juvenile idiopathic arthritis	28.81	9.92	28	123234	1015	29828201
Intentional self-injury	28.52	9.92	10	123252	13522	29815694
Agitation	28.46	9.92	120	123142	53953	29775263
Blood pressure systolic abnormal	28.37	9.92	33	123229	1474	29827742
Suicidal ideation	28.27	9.92	67	123195	36047	29793169
Skin cancer	27.86	9.92	84	123178	7877	29821339
Drug dependence	27.70	9.92	28	123234	21267	29807949
Rheumatoid nodule	26.91	9.92	34	123228	1656	29827560
Cytomegalovirus infection	26.61	9.92	35	123227	23639	29805577
Congenital hand malformation	26.49	9.92	19	123243	447	29828769
Cardiac arrest	26.12	9.92	250	123012	92600	29736616
Lactic acidosis	25.98	9.92	56	123206	31157	29798059
Serum ferritin increased	25.64	9.92	64	123198	5373	29823843
Tendonitis	25.54	9.92	82	123180	7954	29821262
Musculoskeletal pain	25.52	9.92	216	123046	30724	29798492
Selective eating disorder	25.43	9.92	33	123229	1651	29827565
Knee arthroplasty	25.23	9.92	65	123197	5565	29823651
Palmar-plantar erythrodysaesthesia syndrome	25.11	9.92	15	123247	14855	29814361
Caesarean section	24.96	9.92	37	123225	2100	29827116
Peripheral swelling	24.87	9.92	371	122891	60703	29768513
Respiratory arrest	24.76	9.92	52	123210	29206	29800010
Injection site pain	24.68	9.92	211	123051	30099	29799117
Foetal growth restriction	24.58	9.92	49	123213	3536	29825680
Body temperature decreased	24.15	9.92	91	123171	9564	29819652
Medical device implantation	24.15	9.92	19	123243	516	29828700
Agitation neonatal	23.71	9.92	25	123237	1000	29828216
Arthritis bacterial	23.69	9.92	55	123207	4409	29824807
Poisoning	23	9.92	9	123253	11373	29817843
Cardiac failure	22.87	9.92	226	123036	83192	29746024
Hypoglycaemia	22.79	9.92	120	123142	50861	29778355
Pain in extremity	22.66	9.92	604	122658	109617	29719599
Febrile neutropenia	22.65	9.92	306	122956	106387	29722829
Infective pulmonary exacerbation of cystic fibrosis	22.57	9.92	4	123258	8568	29820648
Talipes	22.50	9.92	31	123231	1644	29827572
Pneumonia	22.26	9.92	1629	121633	332677	29496539
Cellulitis	22.19	9.92	292	122970	46492	29782724
Joint effusion	21.53	9.92	47	123215	3616	29825600
Vitamin D deficiency	21.45	9.92	58	123204	5112	29824104
Hand deformity	21.26	9.92	32	123230	1841	29827375
Poor venous access	20.86	9.92	37	123225	2443	29826773
Speech disorder developmental	20.84	9.92	25	123237	1154	29828062
Post procedural infection	20.71	9.92	53	123209	4519	29824697
Hyperglycaemia	20.51	9.92	75	123187	35125	29794091
Haemangioma congenital	20.20	9.92	17	123245	509	29828707
Patent ductus arteriosus	20.17	9.92	42	123220	3127	29826089
Prostate cancer	20.15	9.92	168	123094	23789	29805427
Haematocrit decreased	20.11	9.92	204	123058	30495	29798721
Hyperbilirubinaemia neonatal	19.96	9.92	19	123243	671	29828545
Lacrimal disorder	19.95	9.92	14	123248	318	29828898
Cleft lip	19.91	9.92	14	123248	319	29828897
Lung neoplasm malignant	19.71	9.92	118	123144	15014	29814202
Somnolence	19.65	9.92	280	122982	96483	29732733
Off label use	19.33	9.92	834	122428	248456	29580760
Psychotic disorder	19.27	9.92	37	123225	21478	29807738
Substance abuse	19.17	9.92	3	123259	7037	29822179
Shock	19.03	9.92	41	123221	22818	29806398
Jaundice neonatal	18.97	9.92	23	123239	1074	29828142
Anal fistula	18.88	9.92	47	123215	3939	29825277
Bradycardia neonatal	18.84	9.92	21	123241	895	29828321
Malignant melanoma	18.66	9.92	70	123192	7341	29821875
Congenital bladder anomaly	18.61	9.92	13	123249	293	29828923
Delirium	18.52	9.92	95	123167	40536	29788680
Hallucination	18.46	9.92	122	123140	48937	29780279
Wound	18.31	9.92	100	123162	12302	29816914
Infection	18.15	9.92	435	122827	77639	29751577
Pathogen resistance	18.10	9.92	6	123256	8404	29820812
Septic arthritis staphylococcal	18.03	9.92	15	123247	442	29828774
Hydrocele	17.85	9.92	31	123231	2013	29827203
Sedation	17.60	9.92	25	123237	16348	29812868
Urticaria	17.57	9.92	142	123120	54464	29774752
Weight decrease neonatal	17.48	9.92	13	123249	324	29828892
Contraindicated product administered	17.36	9.92	126	123136	17105	29812111
Constipation	17.29	9.92	344	122918	112562	29716654
Altered state of consciousness	17.20	9.92	35	123227	19884	29809332
Therapeutic product effect decreased	17.07	9.92	189	123073	28887	29800329
Aggression	16.99	9.92	86	123176	36821	29792395
Foetal disorder	16.94	9.92	17	123245	641	29828575
Arthrodesis	16.93	9.92	14	123248	409	29828807
Blood pressure diastolic increased	16.91	9.92	36	123226	2722	29826494
Ankyloglossia congenital	16.89	9.92	12	123250	278	29828938
Electrocardiogram QT prolonged	16.78	9.92	83	123179	35752	29793464
Immunodeficiency	16.65	9.92	47	123215	4247	29824969
Injection site bruising	16.60	9.92	67	123195	7271	29821945
Multiple congenital abnormalities	16.58	9.92	15	123247	496	29828720
Renal aplasia	16.51	9.92	17	123245	661	29828555
Tonsil cancer	16.48	9.92	18	123244	750	29828466
Joint stiffness	16.27	9.92	79	123183	9282	29819934
Crohn's disease	16.26	9.92	47	123215	4305	29824911
Hypermobility syndrome	16.26	9.92	11	123251	235	29828981
Joint range of motion decreased	16.24	9.92	57	123205	5788	29823428
Blood creatine phosphokinase increased	16.02	9.92	110	123152	43738	29785478
Depressed level of consciousness	15.97	9.92	92	123170	38130	29791086
Peripheral artery thrombosis	15.90	9.92	31	123231	2201	29827015
Drug withdrawal syndrome neonatal	15.64	9.92	38	123224	3137	29826079
Congenital anomaly	15.60	9.92	23	123239	1299	29827917
Grip strength decreased	15.30	9.92	30	123232	2138	29827078
Mouth ulceration	15.30	9.92	85	123177	10524	29818692
Oropharyngeal pain	15.28	9.92	182	123080	28314	29800902
Injection site swelling	15.19	9.92	74	123188	8706	29820510
Arthritis infective	15.12	9.92	34	123228	2668	29826548
Blood pressure diastolic decreased	14.99	9.92	58	123204	6173	29823043
Weight decreased	14.78	9.92	761	122501	150160	29679056
No adverse event	14.70	9.92	31	123231	17388	29811828
Neck mass	14.66	9.92	23	123239	1372	29827844
Neuroleptic malignant syndrome	14.61	9.92	28	123234	16267	29812949
Multiple organ dysfunction syndrome	14.60	9.92	179	123083	63308	29765908
Renal impairment	14.59	9.92	251	123011	83933	29745283
Vascular insufficiency	14.56	9.92	12	123250	349	29828867
Product quality issue	14.55	9.92	35	123227	18739	29810477
Maternal exposure timing unspecified	14.47	9.92	12	123250	352	29828864
Hepatocellular injury	14.36	9.92	55	123207	25416	29803800
Rash maculo-papular	14.26	9.92	55	123207	25363	29803853
Hernia pain	14.21	9.92	10	123252	228	29828988
Steatorrhoea	14.20	9.92	16	123246	690	29828526
Autism spectrum disorder	14.14	9.92	22	123240	1303	29827913
Sinusitis	14.13	9.92	204	123058	33141	29796075
Umbilical hernia	14.13	9.92	40	123222	3621	29825595
Blood insulin increased	14.02	9.92	12	123250	368	29828848
Emphysema	14.01	9.92	76	123186	9326	29819890
Otitis media	14.00	9.92	32	123230	2539	29826677
Pyelocaliectasis	13.93	9.92	19	123243	998	29828218
Tuberculosis	13.92	9.92	68	123194	8009	29821207
Hypertriglyceridaemia	13.91	9.92	8	123254	8090	29821126
Kidney infection	13.91	9.92	46	123216	4532	29824684
C-reactive protein decreased	13.87	9.92	24	123238	1554	29827662
Acute hepatic failure	13.79	9.92	17	123245	11810	29817406
Anal atresia	13.79	9.92	11	123251	305	29828911
Back disorder	13.77	9.92	55	123207	5939	29823277
Foot deformity	13.70	9.92	38	123224	3399	29825817
Intellectual disability	13.57	9.92	17	123245	821	29828395
Neonatal seizure	13.47	9.92	13	123249	467	29828749
Dermatitis psoriasiform	13.28	9.92	20	123242	1151	29828065
Agranulocytosis	13.28	9.92	46	123216	21896	29807320
Injection site erythema	13.27	9.92	100	123162	13734	29815482
Lung cancer metastatic	13.25	9.92	31	123231	2497	29826719
Plagiocephaly	13.25	9.92	11	123251	323	29828893
Upper respiratory tract infection	13.24	9.92	172	123090	27304	29801912
Blood pressure diastolic abnormal	13.23	9.92	21	123241	1266	29827950
Developmental delay	13.19	9.92	28	123234	2113	29827103
Palindromic rheumatism	13.15	9.92	9	123253	196	29829020
Hepatic failure	13.14	9.92	84	123178	33959	29795257
Excessive cerumen production	13.02	9.92	10	123252	262	29828954
Status epilepticus	12.82	9.92	16	123246	11056	29818160
Foetal distress syndrome	12.80	9.92	18	123244	973	29828243
Gangrene neonatal	12.80	9.92	9	123253	205	29829011
Foetal heart rate deceleration abnormality	12.79	9.92	12	123250	416	29828800
Pulmonary artery stenosis congenital	12.74	9.92	13	123249	500	29828716
Pleural fibrosis	12.74	9.92	22	123240	1422	29827794
Osteonecrosis of jaw	12.69	9.92	37	123225	18581	29810635
Respiratory rate increased	12.57	9.92	71	123191	8844	29820372
Heart rate decreased	12.57	9.92	137	123125	20857	29808359
Knee deformity	12.56	9.92	11	123251	348	29828868
Diverticular perforation	12.54	9.92	35	123227	3142	29826074
Congenital diaphragmatic hernia	12.36	9.92	9	123253	217	29828999
Lung neoplasm	12.34	9.92	44	123218	4502	29824714
Red blood cell sedimentation rate increased	12.27	9.92	61	123201	7234	29821982
Diabetic ketoacidosis	12.24	9.92	30	123232	15956	29813260
Abnormal behaviour	12.20	9.92	59	123203	25564	29803652
Hypocalcaemia	12.15	9.92	46	123216	21330	29807886
Hepatitis	12.14	9.92	49	123213	22307	29806909
Asthma	12.13	9.92	93	123169	36081	29793135
Hypokalaemia	12.12	9.92	140	123122	50052	29779164
Foetal hypokinesia	12.10	9.92	11	123251	366	29828850
Subdural haematoma	12.01	9.92	39	123223	18933	29810283
Red blood cell count decreased	11.95	9.92	163	123099	26158	29803058
Back pain	11.87	9.92	526	122736	102070	29727146
Haemolysis	11.84	9.92	60	123202	7171	29822045
Disease progression	11.73	9.92	245	123017	79629	29749587
Moaning	11.72	9.92	15	123247	740	29828476
Joint instability	11.66	9.92	11	123251	384	29828832
Pulmonary toxicity	11.66	9.92	43	123219	4473	29824743
Cholestasis	11.56	9.92	58	123204	24892	29804324
Immunosuppression	11.51	9.92	47	123215	5128	29824088
Plasma cell myeloma	11.45	9.92	153	123109	53309	29775907
Congenital hydronephrosis	11.39	9.92	14	123248	663	29828553
Hepatic siderosis	11.39	9.92	8	123254	182	29829034
Injection site haemorrhage	11.37	9.92	63	123199	7792	29821424
Finger deformity	11.33	9.92	17	123245	975	29828241
Pancreatic duct stenosis	11.20	9.92	8	123254	187	29829029
Mean cell volume increased	11.20	9.92	26	123236	2084	29827132
Gangrene	11.14	9.92	43	123219	4571	29824645
Polydactyly	11.14	9.92	19	123243	1216	29828000
Folate deficiency	11.12	9.92	17	123245	992	29828224
Proteinuria	11.07	9.92	32	123230	16113	29813103
Tooth fracture	11.02	9.92	34	123228	3228	29825988
Spina bifida	10.99	9.92	10	123252	333	29828883
Colitis ulcerative	10.98	9.92	99	123163	14335	29814881
Squamous cell carcinoma	10.93	9.92	76	123186	10174	29819042
Cleft palate	10.92	9.92	13	123249	595	29828621
Non-Hodgkin's lymphoma	10.90	9.92	23	123239	1728	29827488
Hypotonia neonatal	10.86	9.92	17	123245	1012	29828204
Skin turgor decreased	10.83	9.92	11	123251	421	29828795
Cerebral haemorrhage	10.81	9.92	85	123177	32802	29796414
Exostosis	10.75	9.92	35	123227	3420	29825796
Venoocclusive liver disease	10.71	9.92	7	123255	6606	29822610
Pulmonary tuberculosis	10.71	9.92	44	123218	4813	29824403
Retinopathy hypertensive	10.71	9.92	9	123253	269	29828947
Pharyngitis	10.66	9.92	56	123206	6786	29822430
Inflammation	10.66	9.92	138	123124	21888	29807328
Lipase increased	10.62	9.92	12	123250	8664	29820552
Vitamin B12 deficiency	10.58	9.92	29	123233	2576	29826640
Incorrect route of product administration	10.54	9.92	19	123243	11296	29817920
Necrotising fasciitis streptococcal	10.53	9.92	7	123255	145	29829071
Neutropenia neonatal	10.44	9.92	12	123250	529	29828687
Placental insufficiency	10.43	9.92	6	123256	95	29829121
Blood albumin decreased	10.43	9.92	88	123174	12504	29816712
Oxygen saturation decreased	10.38	9.92	243	123019	43197	29786019
Pulmonary valve stenosis	10.37	9.92	10	123252	359	29828857
Skin lesion	10.31	9.92	119	123143	18375	29810841
Maternal exposure before pregnancy	10.30	9.92	10	123252	362	29828854
Sexual dysfunction	10.21	9.92	6	123256	5995	29823221
Cardio-respiratory arrest	10.20	9.92	170	123092	57136	29772080
Restlessness	10.20	9.92	53	123209	22546	29806670
Microcephaly	10.20	9.92	13	123249	639	29828577
Duodenal perforation	10.18	9.92	18	123244	1186	29828030
Haemoglobinuria	10.18	9.92	12	123250	544	29828672
Skin graft failure	10.17	9.92	7	123255	154	29829062
Decreased vibratory sense	10.12	9.92	10	123252	370	29828846
Drug-induced liver injury	10.12	9.92	49	123213	21225	29807991
Congenital aortic valve incompetence	10.09	9.92	7	123255	156	29829060
Mesothelioma	10.02	9.92	11	123251	461	29828755
Nose deformity	9.97	9.92	7	123255	159	29829057
Ankylosing spondylitis	9.94	9.92	41	123221	4493	29824723

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Proctitis	indication	3951002	DOID:3127
Tinea pedis	indication	6020002	DOID:12403
Wound	indication	13924000
Burn injury	indication	48333001
Candidiasis of skin	indication	49883006
Pityriasis versicolor	indication	56454009	DOID:9060
Hemorrhoids	indication	70153002	DOID:9746
Rectal pain	indication	77880009
Tinea corporis	indication	84849002
Pruritus ani	indication	90446007
Diaper rash	indication	91487003
Eruption of skin	indication	271807003	DOID:0050486
Skin irritation	indication	367466007
Tinea cruris	indication	399029005
Arthropod bite wound	indication	409985002
Itching of skin	indication	418363000
Minor Bacterial Skin Infections	indication
Paronychia	off-label use	71906005	DOID:13117
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Conduction disorder of the heart	contraindication	44808001
Anxiety	contraindication	48694002
Wilson's disease	contraindication	88518009
Anemia due to enzyme deficiency	contraindication	111577008
Open wound	contraindication	125643001
Hb SS disease	contraindication	127040003	DOID:10923
Benign prostatic hyperplasia	contraindication	266569009
Hemochromatosis	contraindication	399187006	DOID:2352
Disorder of coronary artery	contraindication	414024009
Denuded skin	contraindication	418242004
Nervousness	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019034	VUID
N0000147305	NUI
D01170	KEGG_DRUG
4017643	VANDF
4019034	VANDF
4019036	VANDF
C0043491	UMLSCUI
CHEBI:36560	CHEBI
CHEMBL3988900	ChEMBL_ID
D015034	MESH_DESCRIPTOR_UI
SOI2LOH54Z	UNII
14806	PUBCHEM_CID
DB09321	DRUGBANK_ID
11423	RXNORM
5049	MMSL
5709	MMSL
001922	NDDF
398971002	SNOMEDCT_US
42841002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen	HUMAN OTC DRUG LABEL	3	0023-5494	LOTION	80 mg	TOPICAL	OTC MONOGRAPH NOT FINULLL	14 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted)	HUMAN OTC DRUG LABEL	4	0023-5497	LOTION	80 mg	TOPICAL	OTC MONOGRAPH NOT FINULLL	14 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen	HUMAN OTC DRUG LABEL	4	0023-5501	LOTION	10 mg	TOPICAL	OTC MONOGRAPH NOT FINULLL	14 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen	HUMAN OTC DRUG LABEL	2	0023-5675	LOTION	60 mg	TOPICAL	OTC MONOGRAPH NOT FINULLL	14 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen	HUMAN OTC DRUG LABEL	2	0023-5703	LOTION	60 mg	TOPICAL	OTC MONOGRAPH NOT FINULLL	14 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen	HUMAN OTC DRUG LABEL	2	0023-5738	LOTION	120 mg	TOPICAL	OTC MONOGRAPH NOT FINULLL	14 sections
Solbar Shield SPF40	HUMAN OTC DRUG LABEL	2	0096-0682	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Zinc SPF38	HUMAN OTC DRUG LABEL	3	0096-0688	CREAM	0.08 1	TOPICAL	OTC monograph final	8 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0194	PASTE	40 g	TOPICAL	OTC monograph final	11 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0323	CREAM	40 g	TOPICAL	OTC MONOGRAPH FINULLL	12 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0324	OINTMENT	16 g	TOPICAL	OTC MONOGRAPH FINULLL	12 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0333	CREAM	16 g	TOPICAL	OTC monograph final	11 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0334	CREAM	16 g	TOPICAL	OTC monograph final	11 sections
Boudreauxs	HUMAN OTC DRUG LABEL	1	0132-0557	CREAM	16 g	TOPICAL	export only	11 sections
Selan Plus Zinc Oxide	HUMAN OTC DRUG LABEL	2	0159-2200	CREAM	2 g	TOPICAL	OTC monograph final	11 sections
CALENDULA DIAPER RASH CREAM	HUMAN OTC DRUG LABEL	1	0164-2189	CREAM	12 g	TOPICAL	OTC monograph final	8 sections
WHITE MALLOW DIAPER RASH CREAM	HUMAN OTC DRUG LABEL	1	0164-2207	CREAM	14 g	TOPICAL	OTC monograph final	8 sections
ZINC OXIDE	HUMAN OTC DRUG LABEL	1	0168-0062	OINTMENT	200 mg	TOPICAL	OTC monograph final	9 sections
DR SMITHS DIAPER	HUMAN OTC DRUG LABEL	1	0178-0330	OINTMENT	100 mg	TOPICAL	OTC monograph final	12 sections
Dr Smiths Diaper Rash	HUMAN OTC DRUG LABEL	1	0178-0340	SPRAY	10 g	TOPICAL	OTC monograph final	8 sections
Dr Smiths Diaper Rash	HUMAN OTC DRUG LABEL	1	0178-0345	SPRAY	10 g	TOPICAL	OTC monograph final	8 sections
Dr Smiths Diaper Rash	HUMAN OTC DRUG LABEL	1	0178-0348	SPRAY	10 g	TOPICAL	OTC monograph final	8 sections
Dr. Smiths Rash and Skin	HUMAN OTC DRUG LABEL	1	0178-0370	OINTMENT	10 g	TOPICAL	OTC monograph not final	12 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	25 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN OTC DRUG LABEL	14	0178-0829	TABLET	25 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	13	0178-0858	TABLET	25 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	14	0178-0859	TABLET	25 mg	ORAL	Unapproved drug other	9 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	25 mg	ORAL	Unapproved drug other	11 sections
Caladryl	HUMAN OTC DRUG LABEL	3	0187-5465	LOTION	78.65 mg	TOPICAL	OTC monograph final	14 sections
Calcemin Advance	HUMAN OTC DRUG LABEL	5	0280-0272	TABLET, FILM COATED	7.50 mg	ORAL	Export only	2 sections