zinc oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4240 1314-13-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zinc oxide
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
  • Molecular weight: 81.38
  • Formula: OZn
  • CLOGP: -1.12
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2 64
kinase-selectivity-class GRK2,GSK3B,HIPK2,MAP3K14,PIK3CG 5
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 16, 2006 FDA DELCOR ASSET

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1684.72 9.97 6486 788350 320378 89513233
Systemic lupus erythematosus 1676.22 9.97 6945 787891 354951 89478660
Glossodynia 1425.41 9.97 6093 788743 315686 89517925
Hand deformity 1188.12 9.97 5448 789388 290914 89542697
Arthropathy 1164.73 9.97 6304 788532 359938 89473673
Abdominal discomfort 1036.04 9.97 7448 787388 469880 89363731
Alopecia 1023.19 9.97 7635 787201 487436 89346175
Wound 986.45 9.97 5250 789586 297730 89535881
Synovitis 880.59 9.97 5420 789416 324332 89509279
Completed suicide 872.08 9.97 119 794717 144939 89688672
Toxicity to various agents 844.51 9.97 768 794068 287078 89546533
Maternal exposure during pregnancy 818.14 9.97 5683 789153 354380 89479231
Pericarditis 802.50 9.97 4567 790269 265584 89568027
Anti-cyclic citrullinated peptide antibody positive 801.53 9.97 4144 790692 232289 89601322
Swelling 795.58 9.97 6338 788498 412720 89420891
Discomfort 709.38 9.97 4473 790363 269862 89563749
Contraindicated product administered 707.15 9.97 5019 789817 315120 89518491
Infusion related reaction 664.53 9.97 6064 788772 410716 89422895
Joint swelling 652.61 9.97 7014 787822 496286 89337325
Duodenal ulcer perforation 649.05 9.97 3729 791107 217559 89616052
Death 597.61 9.97 2030 792806 454521 89379090
Helicobacter infection 596.35 9.97 3715 791121 223135 89610476
Drug interaction 552.72 9.97 986 793850 275467 89558144
Intentional overdose 549.89 9.97 83 794753 93751 89739860
Rheumatoid arthritis 506.04 9.97 5131 789705 357483 89476128
Rheumatoid factor positive 491.03 9.97 2874 791962 168776 89664835
Pain 488.84 9.97 11800 783036 984541 88849070
Psoriatic arthropathy 454.24 9.97 3493 791343 224842 89608769
Febrile neutropenia 433.33 9.97 449 794387 157900 89675711
Hepatic enzyme increased 419.46 9.97 4923 789913 355813 89477798
Drug abuse 405.44 9.97 110 794726 82237 89751374
Suicide attempt 380.21 9.97 96 794740 75303 89758308
Therapeutic product effect decreased 371.39 9.97 3895 790941 273676 89559935
Musculoskeletal stiffness 358.94 9.97 4079 790757 292453 89541158
Disease progression 348.92 9.97 520 794316 156095 89677516
Arthralgia 344.95 9.97 9099 785737 769423 89064188
Impaired healing 340.85 9.97 3344 791492 230855 89602756
Malignant neoplasm progression 337.80 9.97 265 794571 106605 89727006
Product use issue 331.61 9.97 4382 790454 325537 89508074
Depressed level of consciousness 331.59 9.97 112 794724 72672 89760939
Acute kidney injury 317.75 9.97 1586 793250 318801 89514810
Folliculitis 309.70 9.97 2943 791893 201410 89632201
Neutropenia 308.99 9.97 978 793858 223926 89609685
Rheumatic fever 307.99 9.97 2349 792487 150772 89682839
Blister 286.85 9.97 3459 791377 251539 89582072
Cardiac arrest 286.52 9.97 298 794538 104637 89728974
Constipation 283.77 9.97 1378 793458 279017 89554594
Overdose 279.92 9.97 603 794233 157106 89676505
Electrocardiogram QT prolonged 264.75 9.97 153 794683 72303 89761308
Muscle injury 262.13 9.97 2533 792303 174121 89659490
Drug intolerance 259.98 9.97 5434 789402 442157 89391454
Swollen joint count increased 252.88 9.97 1757 793079 109449 89724162
Sleep disorder due to general medical condition, insomnia type 247.52 9.97 1954 792882 126740 89706871
Irritable bowel syndrome 246.95 9.97 2845 791991 204603 89629008
Hyperhidrosis 244.52 9.97 518 794318 135787 89697824
Type 2 diabetes mellitus 241.33 9.97 2786 792050 200458 89633153
Lactic acidosis 234.53 9.97 75 794761 50388 89783223
Somnolence 231.48 9.97 994 793842 208090 89625521
Fibromyalgia 227.97 9.97 2789 792047 203480 89630131
Hypotension 227.27 9.97 1795 793041 323602 89510009
Hypersensitivity 224.96 9.97 5396 789440 449281 89384330
Exposure during pregnancy 224.33 9.97 3130 791706 235280 89598331
Hyponatraemia 223.59 9.97 527 794309 133011 89700600
Nausea 219.66 9.97 7755 787081 1102561 88731050
Treatment failure 218.83 9.97 3814 791022 300114 89533497
Nasopharyngitis 217.27 9.97 4883 789953 402221 89431390
Hip arthroplasty 214.50 9.97 1271 793565 74937 89758674
Sedation 212.77 9.97 78 794758 48093 89785518
Knee arthroplasty 210.64 9.97 1350 793486 81832 89751779
Lower respiratory tract infection 208.00 9.97 3220 791616 247439 89586172
Blood cholesterol increased 200.57 9.97 2743 792093 205269 89628342
C-reactive protein abnormal 199.85 9.97 1849 792987 125580 89708031
Cardiac failure 195.65 9.97 417 794419 109079 89724532
Bradycardia 191.98 9.97 273 794563 83574 89750037
Ill-defined disorder 189.37 9.97 2465 792371 182426 89651185
Drug ineffective for unapproved indication 184.48 9.97 187 794649 66457 89767154
Liver injury 174.65 9.97 2274 792562 168293 89665318
Drug reaction with eosinophilia and systemic symptoms 173.01 9.97 79 794757 42679 89790932
Agitation 172.72 9.97 200 794636 66898 89766713
Neoplasm progression 172.66 9.97 87 794749 44399 89789212
Tremor 172.07 9.97 724 794112 152449 89681162
Stomatitis 170.15 9.97 3368 791468 271330 89562281
Red blood cell sedimentation rate abnormal 168.20 9.97 531 794305 23673 89809938
Diarrhoea 165.15 9.97 6651 788185 932539 88901072
Myelosuppression 162.96 9.97 138 794698 53453 89780158
Serotonin syndrome 162.91 9.97 64 794772 37823 89795788
Cognitive disorder 162.89 9.97 222 794614 69185 89764426
Renal failure 159.34 9.97 600 794236 130407 89703204
Osteoarthritis 157.23 9.97 2501 792335 193229 89640382
Renal impairment 155.78 9.97 443 794393 104978 89728633
Contusion 154.19 9.97 3076 791760 248140 89585471
Thrombocytopenia 151.44 9.97 1139 793697 207586 89626025
Rhabdomyolysis 151.00 9.97 136 794700 51120 89782491
Angioedema 146.78 9.97 213 794623 64663 89768948
Coma 145.01 9.97 259 794577 72373 89761238
Sopor 143.89 9.97 22 794814 24622 89808989
Anaemia 141.28 9.97 2209 792627 350593 89483018
Neuropathy peripheral 140.85 9.97 669 794167 136301 89697310
Syncope 139.93 9.97 642 794194 132021 89701590
Sickle cell anaemia with crisis 139.93 9.97 239 794597 7058 89826553
Chest discomfort 139.84 9.97 680 794156 137685 89695926
Myalgia 137.06 9.97 935 793901 174190 89659421
Hypoglycaemia 136.83 9.97 252 794584 69596 89764015
No adverse event 136.10 9.97 242 794594 67740 89765871
Drug resistance 134.99 9.97 49 794787 30400 89803211
Intentional product use issue 134.50 9.97 2660 792176 214232 89619379
Respiratory failure 134.06 9.97 558 794278 117860 89715751
Respiratory arrest 132.53 9.97 63 794773 33248 89800363
Injury 131.47 9.97 2447 792389 194902 89638709
Joint range of motion decreased 130.80 9.97 1789 793047 133854 89699757
Off label use 127.79 9.97 8147 786689 1094105 88739506
Pregnancy 125.85 9.97 954 793882 61093 89772518
Intentional self-injury 125.39 9.97 50 794786 29284 89804327
Cytokine release syndrome 120.69 9.97 47 794789 27926 89805685
Metabolic acidosis 119.96 9.97 189 794647 55487 89778124
Multiple organ dysfunction syndrome 119.78 9.97 263 794573 68073 89765538
Intentional product misuse 118.55 9.97 396 794440 89208 89744403
Neutrophil count decreased 118.35 9.97 284 794552 71248 89762363
Cardio-respiratory arrest 117.39 9.97 235 794601 62905 89770706
COVID-19 117.01 9.97 933 793903 167910 89665701
Sinusitis 116.66 9.97 3883 790953 339205 89494406
Facet joint syndrome 116.36 9.97 1348 793488 97041 89736570
Grip strength decreased 115.19 9.97 1281 793555 91295 89742316
Palpitations 115.10 9.97 714 794122 136014 89697597
General physical health deterioration 114.66 9.97 3995 790841 351120 89482491
Dyspnoea 113.69 9.97 6445 788391 874510 88959101
Inflammation 112.29 9.97 2195 792641 176397 89657214
Weight increased 112.09 9.97 4606 790230 413321 89420290
Live birth 111.25 9.97 1122 793714 77985 89755626
White blood cell count decreased 110.97 9.97 934 793902 166175 89667436
Hyperglycaemia 110.79 9.97 172 794664 50798 89782813
Seizure 109.68 9.97 835 794001 151794 89681817
Balance disorder 109.54 9.97 458 794378 96622 89736989
Dysphagia 109.32 9.97 559 794277 111719 89721892
Peripheral swelling 108.76 9.97 4544 790292 408562 89425049
Orthostatic hypotension 108.38 9.97 124 794712 41703 89791908
Device expulsion 108.36 9.97 119 794717 40767 89792844
Dry skin 107.97 9.97 402 794434 87671 89745940
Hepatic function abnormal 107.66 9.97 149 794687 46139 89787472
Multiple sclerosis relapse 107.61 9.97 183 794653 52122 89781489
Vision blurred 106.89 9.97 550 794286 109743 89723868
Sedation complication 106.42 9.97 12 794824 16932 89816679
Hepatic failure 105.98 9.97 115 794721 39613 89793998
Altered state of consciousness 105.02 9.97 74 794762 31458 89802153
Tachycardia 104.81 9.97 881 793955 156792 89676819
Blood glucose increased 104.61 9.97 454 794382 94792 89738819
Accidental exposure to product 104.03 9.97 131 794705 42235 89791376
Mobility decreased 103.15 9.97 2905 791931 247829 89585782
Metastases to bone 101.83 9.97 48 794788 25457 89808154
Hypoxia 101.33 9.97 312 794524 72087 89761524
Pulmonary fibrosis 101.24 9.97 1412 793424 106091 89727520
Dehydration 100.86 9.97 1154 793682 193293 89640318
Rash 98.75 9.97 8183 786653 787917 89045694
Product dose omission issue 98.15 9.97 1884 792952 289803 89543808
Fatigue 97.60 9.97 11549 783287 1142474 88691137
Palmar-plantar erythrodysaesthesia syndrome 95.68 9.97 64 794772 27959 89805652
Deep vein thrombosis postoperative 95.61 9.97 996 793840 69813 89763798
Platelet count decreased 95.29 9.97 756 794080 136213 89697398
Anaphylactic reaction 95.02 9.97 419 794417 87105 89746506
Suicidal ideation 93.90 9.97 332 794504 73523 89760088
Encephalopathy 93.26 9.97 165 794671 46279 89787332
Hepatocellular injury 92.50 9.97 71 794765 28887 89804724
Drug withdrawal syndrome 92.29 9.97 70 794766 28653 89804958
Dysarthria 91.97 9.97 214 794622 54268 89779343
Condition aggravated 91.82 9.97 6229 788607 589316 89244295
Blood pressure systolic abnormal 91.49 9.97 376 794460 19102 89814509
Food allergy 91.37 9.97 55 794781 25423 89808188
Blood pressure diastolic abnormal 91.20 9.97 381 794455 19500 89814111
Hallucination 91.07 9.97 286 794550 65673 89767938
Hyperkalaemia 90.89 9.97 280 794556 64684 89768927
Restlessness 90.29 9.97 108 794728 35612 89797999
Shock 90.10 9.97 72 794764 28706 89804905
Feeling abnormal 90.09 9.97 984 793852 166251 89667360
Temperature regulation disorder 89.89 9.97 11 794825 14568 89819043
Wrong technique in product usage process 88.83 9.97 325 794511 71246 89762365
Lip dry 88.70 9.97 1310 793526 99645 89733966
Creatinine renal clearance decreased 87.97 9.97 28 794808 18871 89814740
Infection 87.27 9.97 3947 790889 358147 89475464
Anxiety 87.24 9.97 2059 792777 307713 89525898
Anaphylactic shock 87.17 9.97 89 794747 31528 89802083
Asthenia 86.27 9.97 3814 791022 529937 89303674
Vomiting 85.23 9.97 5861 788975 782432 89051179
Skin exfoliation 85.20 9.97 307 794529 67606 89766005
Rash erythematous 84.56 9.97 290 794546 64814 89768797
Sepsis 83.83 9.97 1092 793744 178722 89654889
Cardiac failure congestive 83.25 9.97 515 794321 98179 89735432
Cytomegalovirus infection 82.73 9.97 67 794769 26535 89807076
Disturbance in attention 81.98 9.97 182 794654 46927 89786684
Ejection fraction decreased 81.80 9.97 66 794770 26187 89807424
Sciatica 81.55 9.97 1296 793540 100086 89733525
Drug dependence 81.49 9.97 82 794754 29245 89804366
Foot deformity 80.98 9.97 840 793996 58811 89774800
Ventricular tachycardia 80.96 9.97 59 794777 24649 89808962
Wound infection 80.69 9.97 1347 793489 105055 89728556
Leukopenia 80.61 9.97 534 794302 100176 89733435
Blood calcium decreased 79.81 9.97 88 794748 30094 89803517
Disability assessment scale score increased 79.70 9.97 132 794704 3799 89829812
Cholestasis 78.41 9.97 123 794713 36176 89797435
Diabetic ketoacidosis 77.76 9.97 60 794776 24347 89809264
Cough 76.85 9.97 2558 792278 366404 89467207
Obesity 76.49 9.97 1326 793510 104181 89729430
Arthritis 76.34 9.97 1965 792871 165350 89668261
Product use in unapproved indication 76.07 9.97 2306 792530 333930 89499681
Mydriasis 75.89 9.97 19 794817 14993 89818618
Joint effusion 75.52 9.97 358 794478 19352 89814259
Autoimmune disorder 75.51 9.97 1016 793820 75728 89757883
Red blood cell sedimentation rate increased 75.41 9.97 1079 793757 81516 89752095
Drug level increased 74.46 9.97 80 794756 27682 89805929
Abortion spontaneous 74.23 9.97 763 794073 53293 89780318
Back pain 73.80 9.97 2167 792669 315008 89518603
Myocardial infarction 73.66 9.97 585 794251 105387 89728224
Personality disorder 72.90 9.97 11 794825 12433 89821178
Blood creatinine increased 72.66 9.97 555 794281 100831 89732780
Metastases to liver 71.85 9.97 88 794748 28719 89804892
Flushing 71.44 9.97 468 794368 88023 89745588
Respiratory depression 70.87 9.97 24 794812 15551 89818060
Blood pressure systolic increased 70.60 9.97 803 794033 57542 89776069
C-reactive protein increased 70.55 9.97 2087 792749 179302 89654309
Blood pressure decreased 70.03 9.97 378 794458 74517 89759094
Gamma-glutamyltransferase increased 69.91 9.97 142 794694 37810 89795801
Ascites 69.49 9.97 202 794634 47538 89786073
Neurotoxicity 69.38 9.97 52 794784 21415 89812196
Acute hepatic failure 68.70 9.97 58 794778 22503 89811108
Hypokalaemia 68.42 9.97 777 794059 130339 89703272
Erythema 68.11 9.97 1511 793325 227735 89605876
Fluid retention 68.06 9.97 472 794364 87619 89745992
Disorientation 67.67 9.97 182 794654 43932 89789679
Hypercholesterolaemia 67.48 9.97 1252 793584 99640 89733971
Torsade de pointes 66.34 9.97 25 794811 15157 89818454
Extrapyramidal disorder 66.14 9.97 30 794806 16273 89817338
Dermatitis atopic 65.94 9.97 65 794771 23407 89810204
Blood pressure fluctuation 65.52 9.97 726 794110 51687 89781924
Blood creatine phosphokinase increased 65.52 9.97 124 794712 33899 89799712
Depressed mood 65.03 9.97 224 794612 49998 89783613
Pulmonary embolism 64.88 9.97 784 794052 130036 89703575
Aphasia 64.64 9.97 178 794658 42634 89790977
Cerebral haemorrhage 63.73 9.97 129 794707 34393 89799218
Disease recurrence 63.47 9.97 148 794688 37505 89796106
Unresponsive to stimuli 63.33 9.97 151 794685 37970 89795641
Osteonecrosis of jaw 63.30 9.97 157 794679 38946 89794665
Hemiparesis 63.02 9.97 114 794722 31705 89801906
Joint destruction 62.81 9.97 257 794579 13030 89820581
Metastases to central nervous system 62.72 9.97 38 794798 17504 89816107
Blood alkaline phosphatase increased 62.55 9.97 214 794622 47865 89785746
Breast cancer stage III 62.54 9.97 1065 793771 83382 89750229
Musculoskeletal pain 62.48 9.97 1955 792881 169296 89664315
Adjustment disorder with depressed mood 62.01 9.97 766 794070 55987 89777624
Cerebrovascular accident 61.77 9.97 739 794097 122794 89710817
Loss of consciousness 61.61 9.97 862 793974 139376 89694235
Dislocation of vertebra 61.41 9.97 756 794080 55212 89778399
Dizziness 60.85 9.97 4398 790438 584886 89248725
Thrombotic microangiopathy 60.77 9.97 31 794805 15712 89817899
Withdrawal syndrome 60.30 9.97 65 794771 22459 89811152
Joint stiffness 60.28 9.97 991 793845 77051 89756560
Road traffic accident 60.11 9.97 1300 793536 106326 89727285
Parkinsonism 60.07 9.97 24 794812 14041 89819570
Juvenile idiopathic arthritis 59.49 9.97 117 794719 3860 89829751
Bursitis 59.40 9.97 1544 793292 130110 89703501
Exposure via skin contact 59.30 9.97 11 794825 10694 89822917
Foetal exposure during pregnancy 59.20 9.97 607 794229 42368 89791243
Vertigo 59.02 9.97 364 794472 69447 89764164
Emotional distress 58.72 9.97 148 794688 36514 89797097
Akathisia 58.63 9.97 13 794823 11146 89822465
Therapy partial responder 58.58 9.97 64 794772 21979 89811632
Gait inability 58.56 9.97 1691 793145 144765 89688846
Bone erosion 58.52 9.97 717 794119 52304 89781307
Peripheral venous disease 58.43 9.97 1048 793788 82873 89750738
Bone pain 58.41 9.97 312 794524 61671 89771940
Hemiplegia 57.79 9.97 35 794801 16125 89817486
Chronic kidney disease 57.73 9.97 235 794601 49956 89783655
Angina pectoris 57.51 9.97 165 794671 38995 89794616
Exposure to toxic agent 57.43 9.97 3 794833 7964 89825647
Device difficult to use 57.22 9.97 42 794794 17483 89816128
Posterior reversible encephalopathy syndrome 57.04 9.97 67 794769 22272 89811339
Eating disorder 57.03 9.97 99 794737 27974 89805637
Dysgeusia 56.81 9.97 252 794584 52308 89781303
Psoriasis 56.36 9.97 1696 793140 146058 89687553
Atrial fibrillation 56.33 9.97 828 794008 132783 89700828
Gastrointestinal disorder 56.24 9.97 2772 792064 253915 89579696
Polyarthritis 56.16 9.97 313 794523 18037 89815574
Adverse event 55.90 9.97 1387 793449 116031 89717580
Skin haemorrhage 55.81 9.97 63 794773 21317 89812294
Carotid artery thrombosis 55.71 9.97 7 794829 9085 89824526
Hypothermia 55.32 9.97 34 794802 15541 89818070
Polyneuropathy 54.98 9.97 53 794783 19288 89814323
Disseminated intravascular coagulation 54.56 9.97 65 794771 21473 89812138
Pain in jaw 54.36 9.97 226 794610 47759 89785852
Osteoporosis 54.23 9.97 1167 793669 95364 89738247
Ventricular fibrillation 53.70 9.97 28 794808 14016 89819595
Inappropriate antidiuretic hormone secretion 53.66 9.97 55 794781 19450 89814161
Swollen tongue 53.59 9.97 214 794622 45742 89787869
Mental status changes 53.41 9.97 206 794630 44473 89789138
Aspartate aminotransferase increased 53.31 9.97 611 794225 102326 89731285
Poisoning 52.97 9.97 34 794802 15183 89818428
Dyskinesia 52.87 9.97 155 794681 36379 89797232
Proteinuria 52.16 9.97 77 794759 23214 89810397
Pancreatitis acute 51.94 9.97 129 794707 31986 89801625
Joint laxity 51.61 9.97 87 794749 2541 89831070
Respiratory distress 51.59 9.97 172 794664 38774 89794837
Basal cell carcinoma 51.56 9.97 483 794353 32906 89800705
Pulmonary oedema 51.29 9.97 326 794510 61754 89771857
Second primary malignancy 50.81 9.97 14 794822 10364 89823247
Blood bilirubin increased 50.33 9.97 203 794633 43267 89790344
Prescribed underdose 50.18 9.97 931 793905 74088 89759523
Arrhythmia 50.08 9.97 196 794640 42136 89791475
Hypomagnesaemia 50.05 9.97 153 794683 35435 89798176
Miosis 49.93 9.97 11 794825 9473 89824138
Eczema 49.89 9.97 266 794570 52604 89781007
Haematotoxicity 49.42 9.97 24 794812 12511 89821100
Brain oedema 49.00 9.97 48 794788 17337 89816274
Alanine aminotransferase increased 48.96 9.97 736 794100 117602 89716009
Muscle spasticity 48.87 9.97 153 794683 35169 89798442
Gestational diabetes 48.70 9.97 203 794633 10379 89823232
Acute respiratory failure 48.70 9.97 202 794634 42716 89790895
Abnormal behaviour 48.56 9.97 77 794759 22551 89811060
Speech disorder 48.40 9.97 220 794616 45365 89788246
Myoclonus 48.39 9.97 58 794778 19110 89814501
Schizophrenia 48.36 9.97 36 794800 14878 89818733
Headache 48.14 9.97 6733 788103 856013 88977598
Lower limb fracture 47.83 9.97 1028 793808 83985 89749626
Diabetes mellitus inadequate control 47.75 9.97 56 794780 18628 89814983
Face oedema 47.58 9.97 82 794754 23236 89810375
Eye pruritus 47.41 9.97 116 794720 28911 89804700
Haemorrhage 47.25 9.97 385 794451 68984 89764627
Bronchospasm 46.83 9.97 68 794768 20641 89812970
Muscle twitching 46.79 9.97 88 794748 24114 89809497
Coordination abnormal 46.47 9.97 72 794764 21284 89812327
Pleural effusion 46.17 9.97 697 794139 111294 89722317
Lethargy 46.01 9.97 344 794492 62795 89770816
Cytopenia 46.00 9.97 51 794785 17398 89816213
Stevens-Johnson syndrome 45.96 9.97 120 794716 29256 89804355
Gastrointestinal haemorrhage 45.83 9.97 538 794298 89710 89743901
Status epilepticus 45.67 9.97 59 794777 18815 89814796
Dystonia 45.63 9.97 48 794788 16771 89816840
Aggression 45.61 9.97 104 794732 26564 89807047
Adjustment disorder 45.39 9.97 14 794822 9628 89823983
Rebound effect 45.31 9.97 13 794823 9371 89824240
Toxic skin eruption 45.10 9.97 43 794793 15731 89817880
Acute generalised exanthematous pustulosis 44.53 9.97 33 794803 13670 89819941
Metastases to lung 44.10 9.97 45 794791 15946 89817665
Multiple drug therapy 43.93 9.97 5 794831 7004 89826607
Caesarean section 43.67 9.97 296 794540 18281 89815330
Illness 43.44 9.97 484 794352 81485 89752126
Psychotic disorder 43.40 9.97 135 794701 31095 89802516
Drug tolerance decreased 43.39 9.97 452 794384 31678 89801933
Loss of personal independence in daily activities 43.29 9.97 1529 793307 134576 89699035
Colitis 43.27 9.97 398 794438 69544 89764067
C-reactive protein 43.18 9.97 443 794393 30924 89802687
Affect lability 43.16 9.97 57 794779 18006 89815605
Arterial occlusive disease 43.06 9.97 28 794808 12418 89821193
Sleep disorder 43.03 9.97 2137 792699 195893 89637718
Fall 42.96 9.97 3639 791197 478171 89355440
Irritability 42.90 9.97 164 794672 35498 89798113
Hypothyroidism 42.86 9.97 281 794555 52846 89780765
Transplant rejection 42.41 9.97 30 794806 12728 89820883
Laryngitis 42.40 9.97 653 794183 50100 89783511
Eosinophilia 42.06 9.97 120 794716 28413 89805198
Hyperlipidaemia 41.99 9.97 86 794750 22830 89810781
Lupus-like syndrome 41.78 9.97 631 794205 48215 89785396
Bronchopulmonary aspergillosis 41.73 9.97 24 794812 11374 89822237
Motor dysfunction 41.69 9.97 65 794771 19165 89814446
Myocarditis 41.42 9.97 36 794800 13770 89819841
Hepatotoxicity 41.41 9.97 234 794602 45608 89788003
Chills 41.18 9.97 863 793973 131118 89702493
Anti-cyclic citrullinated peptide antibody 41.15 9.97 392 794444 26829 89806782
Haemophagocytic lymphohistiocytosis 40.95 9.97 45 794791 15414 89818197
Premature labour 40.83 9.97 228 794608 13148 89820463
Cardiogenic shock 40.58 9.97 97 794739 24371 89809240
Joint dislocation 40.52 9.97 582 794254 44000 89789611
Sinus tachycardia 40.52 9.97 122 794714 28391 89805220
Tardive dyskinesia 40.03 9.97 23 794813 10907 89822704
Cerebral infarction 39.84 9.97 111 794725 26485 89807126
Injection site reaction 39.83 9.97 1074 793762 91006 89742605
Lymphocyte count decreased 39.75 9.97 165 794671 34885 89798726
Drug dose omission by device 39.71 9.97 20 794816 10211 89823400
Forced expiratory volume decreased 39.44 9.97 3 794833 5805 89827806
Hospitalisation 38.98 9.97 841 793995 127259 89706352
Dry mouth 38.91 9.97 1981 792855 182078 89651533
Small for dates baby 38.67 9.97 114 794722 4893 89828718
Mania 38.66 9.97 40 794796 14084 89819527
Mental disorder 38.64 9.97 149 794687 32169 89801442
Muscle rigidity 38.63 9.97 41 794795 14268 89819343
Oedema 38.58 9.97 2137 792699 198158 89635453
Nightmare 38.57 9.97 83 794753 21642 89811969
X-ray abnormal 38.55 9.97 586 794250 44838 89788773
Atrioventricular block complete 38.35 9.97 19 794817 9792 89823819
Sensory loss 38.33 9.97 62 794774 18013 89815598
Tachypnoea 38.17 9.97 81 794755 21228 89812383
Lupus vulgaris 38.13 9.97 581 794255 44478 89789133
Blood pressure diastolic decreased 37.95 9.97 381 794455 26445 89807166
Asphyxia 37.88 9.97 8 794828 7095 89826516
Dyspnoea exertional 37.85 9.97 428 794408 71860 89761751
Deep vein thrombosis 37.50 9.97 571 794265 91049 89742562
Coagulopathy 37.31 9.97 94 794742 23195 89810416
Neck deformity 37.20 9.97 68 794768 2121 89831490
Haemorrhage intracranial 37.10 9.97 47 794789 15115 89818496
Haematoma 37.10 9.97 196 794640 38852 89794759
Disability 37.07 9.97 532 794304 40213 89793398
Stress cardiomyopathy 36.36 9.97 38 794798 13317 89820294
Graft versus host disease 36.28 9.97 13 794823 8131 89825480
Nodule 35.84 9.97 375 794461 26311 89807300
Pulmonary arterial hypertension 35.83 9.97 114 794722 26073 89807538
Melaena 35.72 9.97 170 794666 34627 89798984
Neuroleptic malignant syndrome 35.70 9.97 48 794788 15048 89818563
Hallucination, visual 35.62 9.97 95 794741 22997 89810614
Paralysis 35.58 9.97 29 794807 11449 89822162
Epistaxis 35.36 9.97 529 794307 84596 89749015
International normalised ratio increased 35.33 9.97 256 794580 47060 89786551
Retinitis 35.33 9.97 503 794333 37955 89795656
Aspergillus infection 35.26 9.97 26 794810 10797 89822814
Acute myeloid leukaemia 34.89 9.97 81 794755 20559 89813052
Device use error 34.87 9.97 10 794826 7211 89826400
Tumour lysis syndrome 34.79 9.97 28 794808 11124 89822487
Hepatic cytolysis 34.77 9.97 146 794690 30770 89802841
Gangrene 34.64 9.97 37 794799 12839 89820772
Seronegative arthritis 34.55 9.97 276 794560 17958 89815653
Tuberculosis 34.46 9.97 208 794628 12341 89821270
Urinary retention 34.46 9.97 192 794644 37552 89796059
Pain in extremity 34.20 9.97 4481 790355 446048 89387563
Acute graft versus host disease 34.02 9.97 4 794832 5464 89828147
Paradoxical drug reaction 34.00 9.97 5 794831 5761 89827850
Clostridium difficile colitis 33.98 9.97 120 794716 26586 89807025
Substance abuse 33.52 9.97 4 794832 5402 89828209
Haemoptysis 33.50 9.97 164 794672 33156 89800455
Onychomycosis 33.21 9.97 486 794350 36890 89796721
Infective pulmonary exacerbation of cystic fibrosis 33.09 9.97 25 794811 10254 89823357
Product preparation error 32.97 9.97 25 794811 10236 89823375
Cardiotoxicity 32.62 9.97 31 794805 11358 89822253
Drug hypersensitivity 32.51 9.97 3564 791272 460045 89373566
Bradyphrenia 32.49 9.97 13 794823 7599 89826012
Tinnitus 32.28 9.97 233 794603 42869 89790742
Ischaemic stroke 32.11 9.97 94 794742 22072 89811539
Multiple-drug resistance 32.03 9.97 14 794822 7762 89825849
Mucosal inflammation 31.84 9.97 337 794499 57288 89776323
Rheumatoid nodule 31.78 9.97 293 794543 19873 89813738
Wheelchair user 31.74 9.97 144 794692 7641 89825970
Ventricular septal defect 31.68 9.97 112 794724 5295 89828316
Pericardial effusion 31.68 9.97 191 794645 36642 89796969
Jaundice 31.58 9.97 162 794674 32355 89801256
Sleep apnoea syndrome 31.49 9.97 157 794679 31590 89802021
Complication of device removal 31.46 9.97 8 794828 6247 89827364
Infusion site pain 31.36 9.97 80 794756 19658 89813953
Swelling face 31.28 9.97 513 794323 80839 89752772
Cardiomyopathy 31.26 9.97 83 794753 20123 89813488
Maternal drugs affecting foetus 31.26 9.97 108 794728 5047 89828564
Multiple fractures 31.21 9.97 166 794670 9396 89824215
Psychomotor hyperactivity 31.06 9.97 40 794796 12773 89820838
Lymphopenia 31.03 9.97 100 794736 22781 89810830
Epstein-Barr virus infection 31 9.97 27 794809 10317 89823294
Diabetes mellitus 30.94 9.97 392 794444 64483 89769128
Acute graft versus host disease in skin 30.82 9.97 3 794833 4753 89828858
Hypoaesthesia 30.79 9.97 3177 791659 311033 89522578
Skin burning sensation 30.77 9.97 80 794756 19531 89814080
Device related infection 30.75 9.97 119 794717 25667 89807944
Heart rate decreased 30.74 9.97 649 794187 52856 89780755
Nervousness 30.68 9.97 174 794662 33882 89799729
Hepatic cirrhosis 30.64 9.97 749 794087 62504 89771107
Glycosylated haemoglobin increased 30.60 9.97 56 794780 15506 89818105
Pseudomonas infection 30.58 9.97 52 794784 14813 89818798
Inappropriate schedule of product administration 30.57 9.97 1042 793794 148891 89684720
Influenza like illness 30.44 9.97 510 794326 80101 89753510
Complication of device insertion 30.37 9.97 28 794808 10408 89823203
Exostosis 30.36 9.97 644 794192 52490 89781121
Maternal exposure before pregnancy 30.25 9.97 185 794651 11028 89822583
Lung disorder 30.22 9.97 1606 793230 148277 89685334
Immune reconstitution inflammatory syndrome 29.94 9.97 12 794824 7007 89826604
Tenderness 29.94 9.97 364 794472 26504 89807107
Lip swelling 29.75 9.97 207 794629 38403 89795208
Leukocytosis 29.75 9.97 155 794681 30835 89802776
Febrile bone marrow aplasia 29.69 9.97 25 794811 9713 89823898
Product administration error 29.58 9.97 125 794711 26298 89807313
Genital haemorrhage 29.54 9.97 20 794816 8682 89824929
Onychomadesis 29.44 9.97 567 794269 45431 89788180
Panic attack 29.35 9.97 125 794711 26240 89807371
Dysphonia 29.05 9.97 384 794452 62700 89770911
Dysuria 29.02 9.97 214 794622 39187 89794424
Product prescribing issue 28.93 9.97 17 794819 7962 89825649
Crying 28.91 9.97 121 794715 25524 89808087
Rash maculo-papular 28.88 9.97 225 794611 40708 89792903
Product prescribing error 28.81 9.97 151 794685 29994 89803617
Obstructive airways disorder 28.58 9.97 123 794713 25746 89807865
Accidental overdose 28.52 9.97 139 794697 28134 89805477
Nasal polyps 28.46 9.97 32 794804 10848 89822763
Pathogen resistance 28.43 9.97 18 794818 8097 89825514
Circulatory collapse 28.39 9.97 117 794719 24787 89808824
Toxic epidermal necrolysis 28.33 9.97 168 794668 32360 89801251
Fear 28.28 9.97 65 794771 16557 89817054
Device dislocation 28.27 9.97 161 794675 31321 89802290
Hot flush 28.17 9.97 360 794476 59128 89774483
Wheezing 28.05 9.97 2439 792397 235641 89597970
Interstitial lung disease 28.01 9.97 486 794350 75919 89757692
Delusion 27.94 9.97 49 794787 13791 89819820
Erythema multiforme 27.90 9.97 40 794796 12206 89821405
Sinus disorder 27.88 9.97 182 794654 34265 89799346
Acute respiratory distress syndrome 27.81 9.97 143 794693 28543 89805068
Urinary incontinence 27.69 9.97 204 794632 37362 89796249
Hypophagia 27.53 9.97 193 794643 35744 89797867
Rhinitis allergic 27.47 9.97 67 794769 16718 89816893
Premature rupture of membranes 27.46 9.97 109 794727 5449 89828162
Pulmonary hypertension 27.16 9.97 240 794596 42283 89791328
Respiratory acidosis 27.11 9.97 19 794817 8100 89825511
Aspiration 27.00 9.97 61 794775 15632 89817979
Hypomania 26.93 9.97 23 794813 8874 89824737
Blood potassium decreased 26.82 9.97 278 794558 47449 89786162
Heart rate increased 26.81 9.97 769 794067 112133 89721478
Sinus bradycardia 26.71 9.97 69 794767 16883 89816728
Ketoacidosis 26.56 9.97 8 794828 5587 89828024
Dyspepsia 26.54 9.97 2050 792786 196110 89637501
Blood urea increased 26.53 9.97 157 794679 30256 89803355
Pemphigoid 26.52 9.97 24 794812 9002 89824609
Blood pressure diastolic increased 26.48 9.97 199 794637 12707 89820904
Transaminases increased 26.45 9.97 204 794632 36988 89796623
Finger deformity 26.24 9.97 420 794416 32477 89801134
Blood glucose decreased 26.13 9.97 111 794725 23318 89810293
Abdominal pain 26.05 9.97 3055 791781 392666 89440945
Treatment noncompliance 26.02 9.97 309 794527 51418 89782193
Right ventricular failure 26.00 9.97 84 794752 19121 89814490
Breast cancer metastatic 25.89 9.97 59 794777 15073 89818538
Subarachnoid haemorrhage 25.88 9.97 76 794760 17828 89815783
Incorrect dose administered 25.84 9.97 512 794324 78418 89755193
Eye irritation 25.78 9.97 183 794653 33795 89799816
Middle insomnia 25.77 9.97 69 794767 16682 89816929
Toxic encephalopathy 25.72 9.97 23 794813 8676 89824935
Hypervolaemia 25.55 9.97 175 794661 32582 89801029
Renal tubular necrosis 25.51 9.97 56 794780 14499 89819112
Device breakage 25.48 9.97 53 794783 13991 89819620
Dysmorphism 25.36 9.97 64 794772 2504 89831107
Hypophosphataemia 25.34 9.97 58 794778 14796 89818815
Vascular device infection 25.34 9.97 41 794795 11911 89821700
Bradykinesia 25.27 9.97 14 794822 6774 89826837
Acute chest syndrome 25.25 9.97 40 794796 1108 89832503
Multiple sclerosis 25.21 9.97 142 794694 27698 89805913
Anuria 25.17 9.97 58 794778 14760 89818851
Cytomegalovirus infection reactivation 25.07 9.97 19 794817 7781 89825830
Body temperature decreased 24.97 9.97 319 794517 23497 89810114
Hyperbilirubinaemia 24.94 9.97 53 794783 13883 89819728
Pulmonary congestion 24.94 9.97 87 794749 19346 89814265
Eosinophil count increased 24.90 9.97 48 794788 13033 89820578
Colitis microscopic 24.88 9.97 37 794799 11122 89822489
Labelled drug-drug interaction medication error 24.83 9.97 57 794779 14525 89819086
Presyncope 24.76 9.97 170 794666 31635 89801976
Polyuria 24.69 9.97 31 794805 10009 89823602
Enthesopathy 24.64 9.97 154 794682 9250 89824361
Mood altered 24.62 9.97 73 794763 17071 89816540
Drug effective for unapproved indication 24.55 9.97 20 794816 7898 89825713
Myopathy 24.54 9.97 51 794785 13467 89820144
Sexual dysfunction 24.44 9.97 6 794830 4798 89828813
Atrial tachycardia 24.34 9.97 11 794825 5979 89827632
Limb deformity 24.32 9.97 86 794750 4066 89829545
Paranoia 24.03 9.97 48 794788 12860 89820751
Pallor 24.01 9.97 188 794648 33977 89799634
Breast cancer female 23.91 9.97 60 794776 14826 89818785
Smear cervix abnormal 23.76 9.97 71 794765 3071 89830540
Glomerular filtration rate decreased 23.66 9.97 73 794763 16859 89816752
Pulseless electrical activity 23.66 9.97 26 794810 8906 89824705
Multiple allergies 23.60 9.97 62 794774 15084 89818527
Ankylosing spondylitis 23.38 9.97 196 794640 12937 89820674
Dissociation 23.38 9.97 15 794821 6700 89826911
Bradypnoea 23.34 9.97 6 794830 4652 89828959
Product administered to patient of inappropriate age 23.31 9.97 6 794830 4647 89828964
Throat tightness 23.25 9.97 157 794679 29327 89804284
Lymphoedema 23.22 9.97 54 794782 13699 89819912
Latent tuberculosis 23.22 9.97 68 794768 2908 89830703
Head injury 23.16 9.97 169 794667 31019 89802592
Acidosis 23.16 9.97 48 794788 12688 89820923
Subdural haematoma 23.09 9.97 72 794764 16573 89817038
Cyanosis 23.06 9.97 90 794746 19365 89814246
Agranulocytosis 23.05 9.97 196 794640 34806 89798805
Malignant mediastinal neoplasm 23.00 9.97 43 794793 1365 89832246
Atrioventricular block 22.98 9.97 26 794810 8789 89824822
Atrial septal defect 22.94 9.97 137 794699 8097 89825514
Pulmonary alveolar haemorrhage 22.87 9.97 12 794824 5986 89827625
Prescribed overdose 22.77 9.97 1061 793775 96564 89737047
Blood lactic acid increased 22.76 9.97 26 794810 8752 89824859
Maternal exposure timing unspecified 22.67 9.97 299 794537 22184 89811427
Ileus 22.66 9.97 72 794764 16474 89817137
Tubulointerstitial nephritis 22.55 9.97 130 794706 25213 89808398
Cytomegalovirus viraemia 22.49 9.97 20 794816 7566 89826045
Skin toxicity 22.45 9.97 16 794820 6763 89826848
Complication associated with device 22.40 9.97 91 794745 19358 89814253
Therapy interrupted 22.35 9.97 307 794529 49801 89783810
Acute myocardial infarction 22.25 9.97 197 794639 34693 89798918
Metastases to lymph nodes 22.16 9.97 43 794793 11646 89821965
Respiratory tract congestion 22.10 9.97 145 794691 27265 89806346
Systemic inflammatory response syndrome 22.09 9.97 15 794821 6501 89827110
Generalised oedema 22.04 9.97 89 794747 18964 89814647
Insurance issue 21.93 9.97 39 794797 10919 89822692
Localised infection 21.92 9.97 415 794421 33147 89800464
Ear infection 21.72 9.97 782 794054 68993 89764618
Therapeutic response shortened 21.64 9.97 115 794721 22764 89810847
Sneezing 21.63 9.97 163 794673 29706 89803905
Schizoaffective disorder 21.63 9.97 9 794827 5138 89828473
Rales 21.58 9.97 69 794767 15758 89817853
Antinuclear antibody positive 21.58 9.97 147 794689 9094 89824517
Hepatitis acute 21.56 9.97 39 794797 10848 89822763
Blepharospasm 21.55 9.97 638 794198 54807 89778804
Rheumatoid lung 21.52 9.97 82 794754 4021 89829590
Drug tolerance 21.41 9.97 246 794590 17670 89815941
Graft versus host disease in gastrointestinal tract 21.33 9.97 6 794830 4382 89829229
Sputum discoloured 21.30 9.97 99 794737 20292 89813319
Respiration abnormal 21.29 9.97 23 794813 7940 89825671
Graft versus host disease in skin 21.26 9.97 4 794832 3849 89829762
Bacteraemia 21.15 9.97 112 794724 22188 89811423
Product administration interrupted 21.13 9.97 49 794787 12443 89821168
Electrocardiogram QRS complex prolonged 21.04 9.97 20 794816 7328 89826283
Rotator cuff repair 21.02 9.97 58 794778 2396 89831215
Transplant dysfunction 21.00 9.97 10 794826 5272 89828339
Urinary tract infection 20.94 9.97 2353 792483 303279 89530332
Hallucinations, mixed 20.72 9.97 13 794823 5876 89827735
Blood test abnormal 20.56 9.97 104 794732 20848 89812763
Hyperprolactinaemia 20.52 9.97 11 794825 5422 89828189
Infusion site erythema 20.51 9.97 57 794779 13613 89819998
Salivary hypersecretion 20.41 9.97 30 794806 9062 89824549
Synovial disorder 20.39 9.97 67 794769 3051 89830560
Body height below normal 20.35 9.97 53 794783 2115 89831496
Systemic candida 20.31 9.97 9 794827 4950 89828661
Acute coronary syndrome 20.31 9.97 40 794796 10773 89822838
Oliguria 20.21 9.97 39 794797 10585 89823026
Acute pulmonary oedema 20.18 9.97 33 794803 9547 89824064
Hallucination, auditory 20.18 9.97 72 794764 15903 89817708
Placental disorder 20.11 9.97 44 794792 1567 89832044
Sleep terror 20.10 9.97 7 794829 4457 89829154
Device issue 20.08 9.97 164 794672 29373 89804238
Product adhesion issue 20.04 9.97 10 794826 5132 89828479
Tenosynovitis stenosans 19.92 9.97 78 794758 3875 89829736
Body temperature increased 19.92 9.97 274 794562 44436 89789175
Synovial fluid analysis 19.74 9.97 62 794774 2756 89830855
Plasma cell myeloma 19.73 9.97 246 794590 40582 89793029
Blindness 19.71 9.97 144 794692 26424 89807187
Gastroenteritis viral 19.70 9.97 375 794461 29980 89803631
Bone marrow failure 19.65 9.97 184 794652 32037 89801574
Chronic graft versus host disease 19.50 9.97 6 794830 4133 89829478
Progressive multifocal leukoencephalopathy 19.48 9.97 71 794765 15584 89818027
Troponin increased 19.47 9.97 56 794780 13225 89820386
Developmental hip dysplasia 19.46 9.97 43 794793 1542 89832069
Klebsiella infection 19.42 9.97 38 794798 10259 89823352
Nail operation 19.35 9.97 48 794788 1858 89831753
Dementia 19.35 9.97 126 794710 23735 89809876
Renal injury 19.14 9.97 38 794798 10205 89823406
Post-traumatic stress disorder 19.07 9.97 19 794817 6809 89826802
Bone lesion 19.05 9.97 17 794819 6420 89827191
Hereditary angioedema 19.04 9.97 33 794803 9332 89824279
Chronic obstructive pulmonary disease 19.04 9.97 497 794339 73332 89760279
Lacrimation increased 18.98 9.97 149 794687 26913 89806698
Blood pressure inadequately controlled 18.95 9.97 16 794820 6208 89827403
Generalised tonic-clonic seizure 18.92 9.97 205 794631 34698 89798913
Red blood cell sedimentation rate 18.87 9.97 86 794750 4572 89829039
Tumour marker increased 18.85 9.97 14 794822 5793 89827818
Visual acuity reduced 18.79 9.97 124 794712 23286 89810325
Device leakage 18.73 9.97 37 794799 9954 89823657
Palmoplantar keratoderma 18.60 9.97 4 794832 3503 89830108
Walking aid user 18.59 9.97 425 794411 35081 89798530
End stage renal disease 18.55 9.97 29 794807 8542 89825069
Asthma 18.51 9.97 1850 792986 240310 89593301
Diabetes insipidus 18.45 9.97 3 794833 3209 89830402
Anti-neutrophil cytoplasmic antibody positive vasculitis 18.44 9.97 6 794830 3987 89829624
Coronary artery disease 18.42 9.97 197 794639 33426 89800185
Hyperuricaemia 18.42 9.97 19 794817 6700 89826911
Shock haemorrhagic 18.42 9.97 51 794785 12194 89821417
Thrombosis 18.40 9.97 495 794341 72756 89760855
Stillbirth 18.34 9.97 120 794716 7323 89826288
Foetal anticonvulsant syndrome 18.34 9.97 26 794810 651 89832960
Haematemesis 18.32 9.97 198 794638 33528 89800083
Loose body in joint 18.31 9.97 39 794797 1363 89832248
Hepatitis B reactivation 18.30 9.97 6 794830 3968 89829643
Neck mass 18.28 9.97 75 794761 3807 89829804
Affective disorder 18.21 9.97 25 794811 7768 89825843
Pre-eclampsia 18.16 9.97 162 794674 10886 89822725
Nystagmus 18.11 9.97 22 794814 7205 89826406
Impaired gastric emptying 18.06 9.97 55 794781 12754 89820857
Adenovirus infection 17.99 9.97 9 794827 4613 89828998
Electrolyte imbalance 17.96 9.97 128 794708 23617 89809994
Diplopia 17.93 9.97 163 794673 28551 89805060
Hyperthermia 17.92 9.97 40 794796 10295 89823316
Abdominal distension 17.92 9.97 949 793887 129652 89703959
Bundle branch block right 17.89 9.97 13 794823 5440 89828171
Product dose omission in error 17.80 9.97 106 794730 20397 89813214
Therapy non-responder 17.77 9.97 1411 793425 135293 89698318
Hyperlactacidaemia 17.76 9.97 7 794829 4129 89829482
Bundle branch block left 17.72 9.97 26 794810 7859 89825752
Anhedonia 17.65 9.97 47 794789 11384 89822227
Pharyngeal swelling 17.65 9.97 38 794798 9906 89823705
Pyrexia 17.64 9.97 5348 789488 655137 89178474
Euglycaemic diabetic ketoacidosis 17.62 9.97 17 794819 6184 89827427
Antibody test positive 17.59 9.97 62 794774 2927 89830684
Haemodynamic instability 17.58 9.97 49 794787 11690 89821921
Clostridium test positive 17.56 9.97 13 794823 5388 89828223
Pruritus genital 17.56 9.97 9 794827 4549 89829062
Cleft lip and palate 17.54 9.97 27 794809 729 89832882
Temperature intolerance 17.43 9.97 51 794785 11979 89821632
Injection site erythema 17.42 9.97 1043 793793 97459 89736152
Night sweats 17.38 9.97 1333 793503 127433 89706178
Immune effector cell-associated neurotoxicity syndrome 17.35 9.97 15 794821 5753 89827858
Rhinovirus infection 17.35 9.97 16 794820 5947 89827664
Hypoalbuminaemia 17.31 9.97 76 794760 15821 89817790
Ventricular extrasystoles 17.22 9.97 59 794777 13191 89820420
Anosmia 17.17 9.97 38 794798 9810 89823801
Dermatitis exfoliative 17.14 9.97 14 794822 5522 89828089
Neuralgia 17.08 9.97 185 794651 31315 89802296
Injection site pruritus 16.92 9.97 604 794232 53230 89780381
Ankle arthroplasty 16.90 9.97 59 794777 2772 89830839
Extra dose administered 16.89 9.97 34 794802 9084 89824527
Product storage error 16.87 9.97 106 794730 20135 89813476
Spinal stenosis 16.86 9.97 230 794606 17194 89816417
Pain of skin 16.84 9.97 78 794758 16004 89817607
Postoperative wound infection 16.79 9.97 186 794650 13240 89820371
Hepatic necrosis 16.77 9.97 19 794817 6419 89827192
Amyloid arthropathy 16.73 9.97 42 794794 1638 89831973
Hypoglycaemic coma 16.72 9.97 3 794833 2987 89830624
Peripheral sensory neuropathy 16.70 9.97 35 794801 9215 89824396
Potentiating drug interaction 16.70 9.97 15 794821 5647 89827964
Skin lesion 16.64 9.97 229 794607 37136 89796475
Hypernatraemia 16.55 9.97 36 794800 9351 89824260
Cardiac disorder 16.54 9.97 376 794460 56496 89777115
Infusion site pruritus 16.52 9.97 21 794815 6744 89826867
Blood phosphorus decreased 16.52 9.97 12 794824 5022 89828589
Renal disorder 16.51 9.97 233 794603 37626 89795985
Tenosynovitis 16.51 9.97 198 794638 14369 89819242
Polyhydramnios 16.50 9.97 54 794782 2454 89831157
Facial paralysis 16.47 9.97 75 794761 15459 89818152
Liver disorder 16.47 9.97 1256 793580 120013 89713598
Type 1 diabetes mellitus 16.41 9.97 11 794825 4801 89828810
Nail disorder 16.24 9.97 653 794183 58414 89775197
Neutrophilia 16.23 9.97 16 794820 5762 89827849
Amylase increased 16.21 9.97 23 794813 7049 89826562
Catheter site pain 16.20 9.97 15 794821 5564 89828047
Synovial cyst 16.19 9.97 166 794670 11586 89822025
Trigeminal neuralgia 16.15 9.97 8 794828 4123 89829488
Unevaluable event 16.13 9.97 362 794474 54486 89779125
Human antichimeric antibody positive 16.09 9.97 43 794793 1743 89831868
Immune-mediated enterocolitis 16.06 9.97 11 794825 4746 89828865
Infusion site swelling 16.05 9.97 51 794785 11669 89821942
Feeding disorder 16.03 9.97 89 794747 17423 89816188
Septic shock 15.98 9.97 590 794246 83570 89750041
Congenital arterial malformation 15.95 9.97 17 794819 314 89833297
Blood lactate dehydrogenase increased 15.85 9.97 148 794688 25784 89807827
Pseudomonal sepsis 15.83 9.97 9 794827 4293 89829318
Skin ulcer 15.78 9.97 562 794274 49513 89784098
Spondylitis 15.76 9.97 192 794644 13986 89819625
Femur fracture 15.73 9.97 522 794314 45560 89788051
Maternal exposure during delivery 15.72 9.97 7 794829 3839 89829772
Hyperthyroidism 15.72 9.97 95 794741 18215 89815396
Arthritis infective 15.71 9.97 122 794714 7870 89825741
Product substitution issue 15.69 9.97 93 794743 17915 89815696
Hypogammaglobulinaemia 15.65 9.97 45 794791 10629 89822982
Cardiac failure acute 15.58 9.97 53 794783 11876 89821735
Ileus paralytic 15.57 9.97 13 794823 5072 89828539
Rash macular 15.57 9.97 180 794656 30100 89803511
Enterocolitis 15.55 9.97 44 794792 10446 89823165
Nephropathy toxic 15.49 9.97 58 794778 12630 89820981
Limb reduction defect 15.38 9.97 23 794813 605 89833006
Sleep disorder due to a general medical condition 15.31 9.97 288 794548 44450 89789161
Skin papilloma 15.26 9.97 93 794743 5537 89828074
Dermatitis acneiform 15.23 9.97 20 794816 6334 89827277
Pneumonitis 15.23 9.97 284 794552 43886 89789725
Clear cell renal cell carcinoma 15.21 9.97 39 794797 1541 89832070
Malignant melanoma 15.17 9.97 173 794663 12403 89821208
Laryngeal oedema 15.16 9.97 23 794813 6858 89826753
Candida infection 15.07 9.97 209 794627 33848 89799763
Device physical property issue 15.07 9.97 3 794833 2773 89830838
Lymphatic fistula 15.05 9.97 37 794799 1424 89832187
Erythema of eyelid 15.04 9.97 5 794831 3278 89830333
Pancreatitis 15.00 9.97 482 794354 69344 89764267
Hypertelorism 14.89 9.97 21 794815 523 89833088
Lung opacity 14.84 9.97 19 794817 6083 89827528
Hyperpyrexia 14.79 9.97 12 794824 4749 89828862
Pulmonary haemorrhage 14.74 9.97 30 794806 7983 89825628
Scleritis 14.74 9.97 87 794749 5121 89828490
Staphylococcal infection 14.73 9.97 318 794518 48121 89785490
Personality change 14.70 9.97 26 794810 7295 89826316
Reversible cerebral vasoconstriction syndrome 14.69 9.97 9 794827 4121 89829490
Loss of employment 14.68 9.97 4 794832 2983 89830628
Skin plaque 14.67 9.97 42 794794 9933 89823678
Activated partial thromboplastin time prolonged 14.65 9.97 29 794807 7796 89825815
Pneumonia viral 14.61 9.97 35 794801 8788 89824823
Feeling hot 14.56 9.97 548 794288 77460 89756151
Hypoventilation 14.49 9.97 15 794821 5281 89828330
Breast feeding 14.47 9.97 27 794809 856 89832755
Pneumatosis intestinalis 14.46 9.97 6 794830 3431 89830180
Varicella zoster virus infection 14.43 9.97 8 794828 3869 89829742
Nasal obstruction 14.37 9.97 53 794783 2559 89831052
Nasal oedema 14.35 9.97 103 794733 6481 89827130
Immune thrombocytopenia 14.33 9.97 64 794772 13262 89820349
Full blood count abnormal 14.32 9.97 230 794606 36367 89797244
Retrognathia 14.31 9.97 21 794815 543 89833068
Femoral hernia incarcerated 14.29 9.97 37 794799 1471 89832140
Restless legs syndrome 14.27 9.97 127 794709 22343 89811268
Ataxia 14.26 9.97 96 794740 17946 89815665
Blood sodium decreased 14.25 9.97 164 794672 27449 89806162
Jaundice cholestatic 14.25 9.97 43 794793 10000 89823611
Epstein-Barr virus associated lymphoproliferative disorder 14.23 9.97 3 794833 2664 89830947
Increased appetite 14.22 9.97 54 794782 11711 89821900
Pneumothorax 14.17 9.97 104 794732 19063 89814548
Purpura 14.14 9.97 74 794762 14704 89818907
Exercise tolerance decreased 14.12 9.97 28 794808 7523 89826088
Long QT syndrome 14.08 9.97 9 794827 4028 89829583
Metastasis 14.02 9.97 20 794816 6117 89827494
Abortion incomplete 14.01 9.97 5 794831 3135 89830476
Polydipsia 14.00 9.97 10 794826 4221 89829390
Bone density increased 13.91 9.97 27 794809 882 89832729
Intracranial pressure increased 13.85 9.97 24 794812 6787 89826824
Impaired quality of life 13.76 9.97 133 794703 23011 89810600
Laryngospasm 13.73 9.97 6 794830 3327 89830284
Wound infection pseudomonas 13.71 9.97 44 794792 1979 89831632
Lymph node calcification 13.68 9.97 17 794819 373 89833238
Haematuria 13.53 9.97 220 794616 34717 89798894
Nocardiosis 13.49 9.97 3 794833 2567 89831044
Haemorrhage in pregnancy 13.44 9.97 46 794790 2139 89831472
Iritis 13.44 9.97 66 794770 3620 89829991
Choking 13.42 9.97 57 794779 11976 89821635
Hepatitis cholestatic 13.37 9.97 35 794801 8526 89825085
Device use issue 13.33 9.97 8 794828 3705 89829906
Myocardial ischaemia 13.31 9.97 69 794767 13745 89819866
Cholecystitis chronic 13.28 9.97 43 794793 9783 89823828
Atrial flutter 13.25 9.97 49 794787 10709 89822902
Thirst 13.24 9.97 86 794750 16209 89817402
Speech disorder developmental 13.22 9.97 27 794809 916 89832695
Carotid artery occlusion 13.22 9.97 22 794814 6320 89827291
Neoplasm recurrence 13.22 9.97 6 794830 3253 89830358
Eosinophilic granulomatosis with polyangiitis 13.19 9.97 3 794833 2527 89831084
Hypokinesia 13.18 9.97 82 794754 15615 89817996
Pregnancy with contraceptive device 13.14 9.97 15 794821 5051 89828560
Endophthalmitis 13.13 9.97 13 794823 4672 89828939
Product residue present 13.10 9.97 11 794825 4280 89829331
Short stature 13.10 9.97 29 794807 1041 89832570
Central nervous system lesion 13.10 9.97 55 794781 11591 89822020
Fracture delayed union 13.08 9.97 50 794786 2456 89831155
Crohn's disease 13.06 9.97 80 794756 4771 89828840
Kidney transplant rejection 13.02 9.97 14 794822 4843 89828768
Hyperammonaemia 13 9.97 23 794813 6452 89827159
Anger 12.96 9.97 69 794767 13651 89819960
Atrioventricular block second degree 12.89 9.97 12 794824 4440 89829171
Ulcer haemorrhage 12.84 9.97 312 794524 26009 89807602
Pneumonia bacterial 12.83 9.97 63 794773 12727 89820884
Bezoar 12.82 9.97 4 794832 2730 89830881
Gastroschisis 12.75 9.97 17 794819 401 89833210
Back injury 12.72 9.97 515 794321 46107 89787504
Device malfunction 12.70 9.97 120 794716 20857 89812754
Mouth ulceration 12.68 9.97 449 794387 39525 89794086
Incoherent 12.63 9.97 15 794821 4962 89828649
Brain injury 12.58 9.97 31 794805 7707 89825904
Nail injury 12.58 9.97 24 794812 774 89832837
Product availability issue 12.56 9.97 29 794807 7375 89826236
Clostridium difficile infection 12.51 9.97 233 794603 36012 89797599
Uterine perforation 12.48 9.97 30 794806 7524 89826087
Disturbance in social behaviour 12.47 9.97 11 794825 4177 89829434
Osteonecrosis 12.35 9.97 159 794677 26082 89807529
Metastases to peritoneum 12.27 9.97 11 794825 4144 89829467
Device deployment issue 12.24 9.97 15 794821 4894 89828717
Hypotonia 12.21 9.97 55 794781 11371 89822240
Amenorrhoea 12.19 9.97 57 794779 11665 89821946
Hepatitis fulminant 12.19 9.97 10 794826 3935 89829676
Hyperreflexia 12.18 9.97 25 794811 6632 89826979
Lipase increased 12.17 9.97 53 794783 11058 89822553
Respiratory disorder 12.17 9.97 455 794381 64361 89769250
Major depression 12.17 9.97 46 794790 9989 89823622
Catheter site erythema 12.15 9.97 15 794821 4879 89828732
Abnormal dreams 12.15 9.97 54 794782 11203 89822408
Hypertransaminasaemia 12.12 9.97 85 794751 15740 89817871
International normalised ratio fluctuation 12.07 9.97 6 794830 3087 89830524
Eye swelling 12.07 9.97 183 794653 29203 89804408
Eyelid oedema 12.04 9.97 56 794780 11478 89822133
Blood potassium increased 12.01 9.97 120 794716 20629 89812982
Ageusia 11.99 9.97 87 794749 15989 89817622
Immunosuppressant drug level increased 11.99 9.97 14 794822 4666 89828945
Congenital anomaly 11.99 9.97 96 794740 6251 89827360
Confusional state 11.95 9.97 3675 791161 382530 89451081
Implant site pain 11.93 9.97 4 794832 2608 89831003
Intestinal ischaemia 11.92 9.97 39 794797 8844 89824767
Cerebral haematoma 11.91 9.97 12 794824 4277 89829334
Lung transplant 11.86 9.97 9 794827 3683 89829928
Hypocalcaemia 11.79 9.97 282 794554 42086 89791525
Broncholithiasis 11.77 9.97 14 794822 293 89833318
Lip oedema 11.75 9.97 14 794822 4625 89828986
Terminal state 11.73 9.97 5 794831 2813 89830798
Benign ovarian tumour 11.72 9.97 18 794818 485 89833126
Neutrophil count increased 11.71 9.97 111 794725 19279 89814332
Catheter site haemorrhage 11.71 9.97 9 794827 3659 89829952
Therapeutic response unexpected 11.67 9.97 129 794707 21751 89811860
Cushingoid 11.65 9.97 141 794695 10254 89823357
Ventricular hypokinesia 11.63 9.97 18 794818 5323 89828288
Cystitis haemorrhagic 11.60 9.97 19 794817 5494 89828117
Ingrown hair 11.60 9.97 20 794816 595 89833016
Decreased appetite 11.60 9.97 3030 791806 373510 89460101
Skin weeping 11.60 9.97 5 794831 2795 89830816
Malaise 11.59 9.97 4799 790037 581187 89252424
Pneumonia fungal 11.56 9.97 28 794808 7003 89826608
Hepatic encephalopathy 11.54 9.97 72 794764 13700 89819911
Inadequate analgesia 11.50 9.97 7 794829 3217 89830394
Cholangitis 11.50 9.97 29 794807 7153 89826458
Heparin-induced thrombocytopenia 11.47 9.97 18 794818 5294 89828317
Congenital cerebral cyst 11.47 9.97 13 794823 258 89833353
Micturition urgency 11.46 9.97 55 794781 11178 89822433
Hypercapnia 11.45 9.97 26 794810 6651 89826960
Bacterial infection 11.42 9.97 141 794695 23303 89810308
Oligoarthritis 11.42 9.97 19 794817 549 89833062
Poor quality device used 11.40 9.97 3 794833 2290 89831321
Persecutory delusion 11.40 9.97 7 794829 3201 89830410
Exomphalos 11.39 9.97 19 794817 550 89833061
Cardiac failure chronic 11.39 9.97 20 794816 5626 89827985
Pancreatic steatosis 11.39 9.97 36 794800 1606 89832005
Haemodialysis 11.33 9.97 39 794797 8708 89824903
Metabolic disorder 11.32 9.97 31 794805 7439 89826172
Mental impairment 11.29 9.97 93 794743 16627 89816984
Total lung capacity decreased 11.26 9.97 10 794826 3785 89829826
Upper-airway cough syndrome 11.24 9.97 82 794754 15053 89818558
Sensitisation 11.23 9.97 12 794824 4163 89829448
Inflammatory marker increased 11.23 9.97 127 794709 9087 89824524
Pulmonary function test abnormal 11.17 9.97 5 794831 2734 89830877
Cleft palate 11.17 9.97 31 794805 1285 89832326
Subacute cutaneous lupus erythematosus 11.17 9.97 9 794827 3573 89830038
Skin swelling 11.14 9.97 26 794810 6588 89827023
Type I hypersensitivity 11.11 9.97 12 794824 4143 89829468
Retinal haemorrhage 11.10 9.97 21 794815 5743 89827868
Cold sweat 11.09 9.97 75 794761 14006 89819605
Intraocular pressure increased 11.08 9.97 29 794807 7064 89826547
Drug screen positive 11.03 9.97 10 794826 3747 89829864
Facial pain 11.00 9.97 69 794767 13113 89820498
Ventricular arrhythmia 10.99 9.97 13 794823 4308 89829303
Learning disorder 10.98 9.97 24 794812 854 89832757
Sickle cell anaemia 10.98 9.97 20 794816 622 89832989
Physical deconditioning 10.97 9.97 3 794833 2232 89831379
Osteolysis 10.97 9.97 9 794827 3541 89830070
Human anti-human antibody test 10.95 9.97 16 794820 412 89833199
Metastases to spine 10.94 9.97 10 794826 3733 89829878
Tendonitis 10.93 9.97 255 794581 21117 89812494
Dermatitis contact 10.92 9.97 72 794764 13523 89820088
Liver function test increased 10.89 9.97 875 793961 83980 89749631
Cervical incompetence 10.85 9.97 20 794816 628 89832983
Cholecystitis acute 10.83 9.97 44 794792 9360 89824251
Immunisation 10.81 9.97 3 794833 2210 89831401
Pulmonary tuberculosis 10.76 9.97 76 794760 4758 89828853
Granuloma skin 10.75 9.97 142 794694 10538 89823073
Wrong product administered 10.75 9.97 33 794803 7632 89825979
Intervertebral disc degeneration 10.74 9.97 212 794624 17062 89816549
Blood loss anaemia 10.73 9.97 49 794787 10091 89823520
Cyst rupture 10.72 9.97 23 794813 808 89832803
Colorectal cancer 10.68 9.97 11 794825 3882 89829729
Incorrect product administration duration 10.67 9.97 113 794723 19209 89814402
Anal incontinence 10.63 9.97 91 794745 16139 89817472
Pathological fracture 10.63 9.97 46 794790 9614 89823997
Needle issue 10.59 9.97 75 794761 13859 89819752
Foetal distress syndrome 10.58 9.97 36 794800 1669 89831942
Skin fissures 10.58 9.97 124 794712 20685 89812926
Product physical issue 10.58 9.97 21 794815 5639 89827972
Formication 10.57 9.97 16 794820 4775 89828836
Skin cancer 10.56 9.97 172 794664 13347 89820264
Embolism 10.52 9.97 45 794791 9436 89824175
Cross sensitivity reaction 10.48 9.97 6 794830 2851 89830760
Cardiac tamponade 10.43 9.97 21 794815 5611 89828000
Depressive symptom 10.41 9.97 19 794817 5266 89828345
Cell death 10.40 9.97 7 794829 3048 89830563
Hypochloraemia 10.37 9.97 5 794831 2617 89830994
Lymph gland infection 10.36 9.97 18 794818 539 89833072
Dermatitis 10.32 9.97 135 794701 22085 89811526
Hydronephrosis 10.31 9.97 65 794771 12337 89821274
Apnoea 10.25 9.97 45 794791 9369 89824242
Injection site warmth 10.24 9.97 213 794623 17302 89816309
Cardiopulmonary failure 10.23 9.97 13 794823 4175 89829436
Dialysis 10.14 9.97 58 794778 11271 89822340
Insomnia 10.14 9.97 2685 792151 330789 89502822
Blood parathyroid hormone decreased 10.13 9.97 157 794679 12059 89821552
Staphylococcal sepsis 10.13 9.97 45 794791 9338 89824273
Blood calcium increased 10.12 9.97 63 794773 11995 89821616
Hypoglycaemia neonatal 10.09 9.97 27 794809 1095 89832516
Congestive cardiomyopathy 10.07 9.97 32 794804 7322 89826289
Tension headache 10.06 9.97 33 794803 7476 89826135
Pharyngeal oedema 10.04 9.97 75 794761 13696 89819915
Adverse drug reaction 10.03 9.97 1170 793666 115531 89718080
Pruritus 10.02 9.97 4445 790391 537080 89296531
Talipes 10.02 9.97 35 794801 1645 89831966
Productive cough 10.01 9.97 563 794273 76500 89757111
Vitamin D deficiency 9.97 9.97 102 794734 17454 89816157

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 644.03 10.23 936 218916 41504 42359979
Drug abuse 338.28 10.23 65 219787 104706 42296777
Foetal exposure during pregnancy 333.31 10.23 747 219105 46564 42354919
Toxicity to various agents 274.16 10.23 476 219376 228660 42172823
Psoriatic arthropathy 267.50 10.23 470 219382 24497 42376986
Arthralgia 249.50 10.23 1862 217990 203376 42198107
Completed suicide 194.76 10.23 129 219723 96336 42305147
Drug interaction 194.53 10.23 715 219137 266284 42135199
Psoriasis 163.34 10.23 587 219265 48017 42353466
Sickle cell anaemia with crisis 151.69 10.23 155 219697 4735 42396748
Joint swelling 143.02 10.23 712 219140 67310 42334173
Dysmorphism 138.77 10.23 124 219728 3192 42398291
Intentional overdose 123.96 10.23 55 219797 51401 42350082
Product use in unapproved indication 115.91 10.23 523 219329 183933 42217550
Pain 113.48 10.23 1833 218019 243015 42158468
Arthritis 107.32 10.23 466 219386 41599 42359884
Musculoskeletal stiffness 107.14 10.23 584 219268 57181 42344302
Synovitis 99.86 10.23 237 219615 15330 42386153
Blood pressure fluctuation 97.30 10.23 333 219519 26575 42374908
Off label use 96.62 10.23 2533 217319 635802 41765681
Premature baby 94.90 10.23 299 219553 22854 42378629
Enthesopathy 93.62 10.23 120 219732 4708 42396775
Small for dates baby 90.01 10.23 123 219729 5140 42396343
Blood pressure systolic increased 89.90 10.23 333 219519 27635 42373848
Coma 84.27 10.23 91 219761 53463 42348020
Death 84.03 10.23 1823 218029 469362 41932121
Exposure during pregnancy 82.72 10.23 154 219698 8394 42393089
Arthropathy 82.59 10.23 337 219515 29260 42372223
Tenosynovitis 79.20 10.23 109 219743 4586 42396897
Hepatic function abnormal 77.46 10.23 91 219761 51476 42350007
Acute kidney injury 76.96 10.23 1383 218469 365954 42035529
Disease progression 76.67 10.23 431 219421 143225 42258258
C-reactive protein abnormal 76.42 10.23 156 219696 9105 42392378
Blood pressure systolic abnormal 75.30 10.23 116 219736 5412 42396071
Serotonin syndrome 73.53 10.23 21 219831 25824 42375659
Speech disorder developmental 70.09 10.23 72 219780 2213 42399270
Neonatal respiratory distress syndrome 67.60 10.23 99 219753 4414 42397069
Drug resistance 67.47 10.23 47 219805 34201 42367282
Rhabdomyolysis 66.98 10.23 194 219658 77825 42323658
Sedation 66.71 10.23 37 219815 30438 42371045
Overdose 65.13 10.23 300 219552 104964 42296519
Maternal exposure during pregnancy 64.16 10.23 123 219729 6855 42394628
Blood pressure diastolic abnormal 63.86 10.23 114 219738 6014 42395469
Foetal anticonvulsant syndrome 62.67 10.23 51 219801 1151 42400332
Suicide attempt 61.38 10.23 89 219763 46011 42355472
Drug dependence 61.30 10.23 37 219815 29057 42372426
Intentional product misuse 60.70 10.23 144 219708 61756 42339727
Low birth weight baby 60.04 10.23 148 219704 9807 42391676
Multiple organ dysfunction syndrome 59.76 10.23 277 219575 96758 42304725
Pancytopenia 58.77 10.23 893 218959 116850 42284633
Weight decreased 58.54 10.23 1445 218407 206503 42194980
Alanine aminotransferase abnormal 56.77 10.23 96 219756 4848 42396635
Hypoglycaemia neonatal 55.80 10.23 62 219790 2088 42399395
Osteoarthritis 55.23 10.23 261 219591 24144 42377339
Heart rate decreased 53.36 10.23 347 219505 36185 42365298
Hypospadias 53.07 10.23 78 219774 3489 42397994
Maternal drugs affecting foetus 52.91 10.23 81 219771 3758 42397725
Atrial septal defect 52.35 10.23 122 219730 7797 42393686
Learning disorder 51.35 10.23 44 219808 1069 42400414
Cryptorchism 48.44 10.23 56 219796 1971 42399512
Autism spectrum disorder 48.35 10.23 68 219784 2920 42398563
Blood pressure diastolic decreased 48.16 10.23 140 219712 10235 42391248
Drug ineffective for unapproved indication 48.01 10.23 104 219748 46059 42355424
Peripheral swelling 47.91 10.23 692 219160 89578 42311905
Angioedema 47.31 10.23 92 219760 42385 42359098
Joint effusion 47.08 10.23 98 219754 5799 42395684
Rheumatoid nodule 46.75 10.23 67 219785 2928 42398555
Nasopharyngitis 46.62 10.23 649 219203 83347 42318136
Appendicolith 46.36 10.23 7 219845 13449 42388034
Pain in extremity 45.21 10.23 1056 218796 149548 42251935
Palmar-plantar erythrodysaesthesia syndrome 43.60 10.23 26 219826 20556 42380927
Jaundice neonatal 43.58 10.23 55 219797 2124 42399359
Suicidal ideation 43.37 10.23 117 219735 48044 42353439
Drug ineffective 43.01 10.23 2740 217112 627457 41774026
Bradycardia 42.63 10.23 262 219590 85222 42316261
Haemoglobin decreased 42.61 10.23 938 218914 131533 42269950
Ventricular septal defect 42.25 10.23 79 219773 4320 42397163
Blood pressure diastolic increased 41.60 10.23 98 219754 6307 42395176
Colitis ulcerative 41.56 10.23 254 219598 25921 42375562
No adverse event 41.34 10.23 87 219765 38934 42362549
Syndactyly 41.06 10.23 36 219816 903 42400580
Haematochezia 40.71 10.23 471 219381 57965 42343518
Maternal exposure during breast feeding 40.63 10.23 45 219807 1510 42399973
Cytomegalovirus infection 40.47 10.23 65 219787 32241 42369242
Altered state of consciousness 40.43 10.23 55 219797 29204 42372279
Grip strength decreased 40.31 10.23 69 219783 3519 42397964
Tongue disorder 40.13 10.23 87 219765 5296 42396187
Inflammation 39.78 10.23 305 219547 33542 42367941
Body temperature decreased 39.32 10.23 163 219689 14250 42387233
Hand deformity 39.14 10.23 70 219782 3698 42397785
Infusion related reaction 38.81 10.23 482 219370 60324 42341159
Febrile neutropenia 38.81 10.23 699 219153 185004 42216479
Knee arthroplasty 38.39 10.23 116 219736 8665 42392818
Myelosuppression 38.19 10.23 96 219756 40365 42361118
Foot deformity 37.89 10.23 82 219770 4986 42396497
Neuroleptic malignant syndrome 37.81 10.23 33 219819 21439 42380044
Cardiogenic shock 37.30 10.23 80 219772 35560 42365923
Sopor 37.05 10.23 11 219841 13191 42388292
Sleep disorder due to a general medical condition 37.04 10.23 22 219830 17431 42384052
Blood pressure increased 36.76 10.23 734 219118 101194 42300289
Exposure via breast milk 36.61 10.23 54 219798 2423 42399060
Poisoning 36.53 10.23 15 219837 14684 42386799
C-reactive protein increased 36.03 10.23 493 219359 63067 42338416
Joint laxity 35.58 10.23 24 219828 402 42401081
Malignant neoplasm progression 35.23 10.23 373 219479 108027 42293456
Drug reaction with eosinophilia and systemic symptoms 35.10 10.23 106 219746 41969 42359514
Pathogen resistance 35.08 10.23 8 219844 11442 42390041
Lactic acidosis 34.98 10.23 118 219734 45143 42356340
Anal fissure 34.95 10.23 81 219771 5158 42396325
Foetal growth restriction 34.50 10.23 81 219771 5202 42396281
Red blood cell sedimentation rate increased 34.29 10.23 121 219731 9803 42391680
Abdominal discomfort 33.84 10.23 561 219291 74694 42326789
Depressed level of consciousness 33.80 10.23 130 219722 47840 42353643
Cardiac murmur 33.70 10.23 143 219709 12632 42388851
Bradycardia neonatal 33.49 10.23 38 219814 1310 42400173
Toxic epidermal necrolysis 33.34 10.23 54 219798 26696 42374787
Lower respiratory tract infection 33.25 10.23 342 219510 40864 42360619
Cytokine release syndrome 33.12 10.23 118 219734 44409 42357074
Polyarthritis 33.05 10.23 78 219774 5026 42396457
Developmental delay 32.90 10.23 59 219793 3123 42398360
Ventricular fibrillation 32.89 10.23 66 219786 30057 42371426
Renal impairment 32.77 10.23 387 219465 109841 42291642
Respiratory disorder neonatal 32.13 10.23 45 219807 1925 42399558
Psychotic disorder 31.89 10.23 64 219788 29144 42372339
Wound 31.67 10.23 173 219679 16944 42384539
Acute chest syndrome 31.66 10.23 33 219819 1032 42400451
Acute hepatic failure 31.60 10.23 25 219827 17048 42384435
Tendonitis 31.11 10.23 117 219735 9777 42391706
Pulmonary alveolar haemorrhage 30.99 10.23 19 219833 14797 42386686
Catarrh 30.95 10.23 84 219768 5902 42395581
Drug withdrawal syndrome neonatal 30.89 10.23 70 219782 4391 42397092
Cardiac failure 30.31 10.23 379 219473 106477 42295006
Plagiocephaly 30.25 10.23 25 219827 577 42400906
Drug use disorder 30.13 10.23 8 219844 10325 42391158
Agitation 30.07 10.23 201 219651 64113 42337370
Substance abuse 29.85 10.23 5 219847 8900 42392583
Caesarean section 29.82 10.23 45 219807 2061 42399422
Basal cell carcinoma 29.65 10.23 210 219642 22523 42378960
Hypermobility syndrome 29.24 10.23 20 219832 343 42401140
Talipes 29.17 10.23 46 219806 2190 42399293
Finger deformity 29.16 10.23 39 219813 1596 42399887
Mucocutaneous ulceration 28.99 10.23 23 219829 500 42400983
Dysgraphia 28.91 10.23 49 219803 2479 42399004
Anaphylactic shock 28.82 10.23 48 219804 23469 42378014
Respiratory arrest 28.76 10.23 65 219787 28359 42373124
Forced expiratory volume decreased 28.64 10.23 3 219849 7627 42393856
Congenital hand malformation 28.45 10.23 25 219827 629 42400854
Electrocardiogram QT prolonged 28.25 10.23 139 219713 47806 42353677
Venoocclusive liver disease 28.16 10.23 9 219843 10293 42391190
Cardiac arrest 27.99 10.23 396 219456 108924 42292559
Large for dates baby 27.98 10.23 29 219823 901 42400582
Shock 27.55 10.23 69 219783 29052 42372431
Hypoglycaemia 27.52 10.23 188 219664 59666 42341817
Immune reconstitution inflammatory syndrome 27.48 10.23 9 219843 10134 42391349
Neurotoxicity 27.41 10.23 50 219802 23601 42377882
Therapy partial responder 27.29 10.23 38 219814 19983 42381500
Intentional self-injury 27.21 10.23 23 219829 15179 42386304
Delirium 27.21 10.23 159 219693 52360 42349123
BK virus infection 27.18 10.23 6 219846 8778 42392705
Burns second degree 27.09 10.23 81 219771 6015 42395468
Akathisia 27.07 10.23 10 219842 10441 42391042
Musculoskeletal pain 27.04 10.23 277 219575 33063 42368420
Ankylosing spondylitis 26.98 10.23 89 219763 6967 42394516
Agitation neonatal 26.91 10.23 35 219817 1393 42400090
Haematocrit decreased 26.88 10.23 287 219565 34621 42366862
Cytomegalovirus infection reactivation 26.83 10.23 12 219840 11166 42390317
Post transplant lymphoproliferative disorder 26.71 10.23 7 219845 9113 42392370
Wrong technique in product usage process 26.65 10.23 121 219731 42514 42358969
Respiratory depression 26.54 10.23 35 219817 18833 42382650
Frequent bowel movements 26.33 10.23 195 219657 21212 42380271
Joint range of motion decreased 26.33 10.23 94 219758 7659 42393824
Mucormycosis 26.32 10.23 3 219849 7140 42394343
Diaphragmatic disorder 25.94 10.23 32 219820 1207 42400276
Systemic lupus erythematosus 25.87 10.23 106 219746 9218 42392265
Hyperglycaemia 25.86 10.23 135 219717 45724 42355759
Tuberculosis 25.83 10.23 112 219740 9987 42391496
Language disorder 25.73 10.23 46 219806 2429 42399054
Ultrasound antenatal screen 25.42 10.23 22 219830 542 42400941
Appendicitis 25.33 10.23 42 219810 20571 42380912
Hydrops foetalis 25.06 10.23 27 219825 878 42400605
Aspergillus infection 24.81 10.23 27 219825 15810 42385673
Fatigue 24.76 10.23 2587 217265 433054 41968429
Arthritis infective 24.71 10.23 61 219791 4045 42397438
Foetal disorder 24.44 10.23 29 219823 1050 42400433
Therapeutic product effect decreased 24.40 10.23 309 219543 38841 42362642
Trisomy 18 24.29 10.23 26 219826 839 42400644
Respiratory failure 23.77 10.23 492 219360 127640 42273843
Anal fistula 23.43 10.23 78 219774 6135 42395348
Skin cancer 23.37 10.23 119 219733 11343 42390140
Oxygen saturation decreased 23.37 10.23 466 219386 64221 42337262
Hepatic failure 23.30 10.23 109 219743 37991 42363492
Somnolence 23.27 10.23 552 219300 140553 42260930
Localised infection 23.06 10.23 182 219670 20191 42381292
Nasal disorder 23.05 10.23 39 219813 1970 42399513
Maternal exposure before pregnancy 22.85 10.23 28 219824 1049 42400434
Lung neoplasm malignant 22.75 10.23 173 219679 18974 42382509
Selective eating disorder 22.61 10.23 36 219816 1728 42399755
Astigmatism 22.60 10.23 31 219821 1300 42400183
Parosmia 22.59 10.23 89 219763 7602 42393881
Hyperbilirubinaemia neonatal 22.57 10.23 25 219827 839 42400644
Dyspraxia 22.44 10.23 19 219833 454 42401029
Adenovirus infection 22.44 10.23 4 219848 6805 42394678
Hypokalaemia 22.40 10.23 249 219603 71472 42330011
Gingival pain 22.34 10.23 95 219757 8399 42393084
Drug intolerance 22.31 10.23 558 219294 79866 42321617
Withdrawal syndrome 22.26 10.23 26 219826 14749 42386734
Tachycardia 22.21 10.23 377 219475 100710 42300773
Radiation inflammation 21.83 10.23 27 219825 1021 42400462
Vitamin D deficiency 21.79 10.23 91 219761 7982 42393501
Renal failure 21.61 10.23 570 219282 143156 42258327
Hypotonia neonatal 21.43 10.23 32 219820 1452 42400031
Temperature regulation disorder 21.21 10.23 28 219824 1131 42400352
Knee deformity 21.15 10.23 23 219829 756 42400727
Joint stiffness 21.12 10.23 122 219730 12200 42389283
Motor developmental delay 21.08 10.23 22 219830 689 42400794
Acute graft versus host disease 21.04 10.23 8 219844 8207 42393276
Cellulitis 21.04 10.23 440 219412 61145 42340338
Cleft lip and palate 21.03 10.23 25 219827 907 42400576
Rebound effect 20.98 10.23 6 219846 7373 42394110
Arthrodesis 20.96 10.23 20 219832 561 42400922
Crohn's disease 20.86 10.23 47 219805 2937 42398546
Conjunctivitis allergic 20.54 10.23 3 219849 5908 42395575
Influenza 20.52 10.23 442 219410 61733 42339750
Drug withdrawal syndrome 20.43 10.23 51 219801 21498 42379985
Intellectual disability 20.27 10.23 36 219816 1891 42399592
Umbilical hernia 20.20 10.23 68 219784 5379 42396104
Anal inflammation 20.13 10.23 39 219813 2190 42399293
Thymus disorder 20.03 10.23 14 219838 249 42401234
Blood phosphorus increased 20.01 10.23 21 219831 12504 42388979
Dyslexia 20.01 10.23 16 219836 352 42401131
Serum ferritin increased 19.97 10.23 82 219770 7137 42394346
Steroid dependence 19.92 10.23 78 219774 6644 42394839
SARS-CoV-2 test negative 19.76 10.23 34 219818 1741 42399742
Loss of personal independence in daily activities 19.74 10.23 364 219488 49452 42352031
Suspected suicide 19.66 10.23 4 219848 6195 42395288
Ankyloglossia congenital 19.63 10.23 16 219836 362 42401121
Transient aphasia 19.62 10.23 20 219832 609 42400874
Congenital foot malformation 19.54 10.23 17 219835 422 42401061
Post procedural infection 19.53 10.23 70 219782 5715 42395768
Central nervous system mass 19.48 10.23 23 219829 828 42400655
Wall motion score index abnormal 19.40 10.23 23 219829 832 42400651
Aggression 19.18 10.23 141 219711 44022 42357461
Polyomavirus-associated nephropathy 19.16 10.23 3 219849 5612 42395871
Congenital anomaly 19.14 10.23 31 219821 1510 42399973
Metabolic acidosis 19.12 10.23 173 219679 51685 42349798
Hypopnoea 19.09 10.23 86 219766 7796 42393687
Cystitis haemorrhagic 19.00 10.23 7 219845 7322 42394161
Ear disorder 18.95 10.23 36 219816 1992 42399491
Cardiac septal defect 18.83 10.23 24 219828 936 42400547
Ventricular tachycardia 18.61 10.23 86 219766 30074 42371409
Spinal disorder 18.54 10.23 59 219793 4532 42396951
Airway remodelling 18.45 10.23 23 219829 877 42400606
Proteinuria 18.39 10.23 59 219793 22924 42378559
Blood creatine phosphokinase increased 18.38 10.23 160 219692 48178 42353305
Drug dose omission by device 18.26 10.23 4 219848 5882 42395601
Infection 18.23 10.23 729 219123 111339 42290144
Back pain 18.18 10.23 900 218952 140876 42260607
Pneumonia 18.13 10.23 2463 217389 419686 41981797
Osteonecrosis of jaw 18.12 10.23 45 219807 19004 42382479
Red blood cell sedimentation rate 18.11 10.23 25 219827 1055 42400428
Malignant melanoma 18.07 10.23 96 219756 9304 42392179
Medical device implantation 18.03 10.23 19 219833 602 42400881
Spina bifida 18.03 10.23 16 219836 408 42401075
Pulmonary vasculitis 17.99 10.23 5 219847 6261 42395222
Transfusion-related circulatory overload 17.97 10.23 21 219831 748 42400735
Synovial cyst 17.92 10.23 41 219811 2588 42398895
Cardiotoxicity 17.86 10.23 8 219844 7437 42394046
Syringe issue 17.85 10.23 11 219841 8545 42392938
Multiple congenital abnormalities 17.82 10.23 18 219834 542 42400941
Haemolysis 17.80 10.23 97 219755 9492 42391991
Acute graft versus host disease in skin 17.77 10.23 8 219844 7416 42394067
Headache 17.71 10.23 1449 218403 237920 42163563
Oropharyngeal pain 17.68 10.23 313 219539 42197 42359286
Blood parathyroid hormone decreased 17.68 10.23 31 219821 1612 42399871
Renal aplasia 17.66 10.23 21 219831 762 42400721
Fistula discharge 17.61 10.23 25 219827 1083 42400400
Fall 17.56 10.23 1421 218431 233099 42168384
Intervertebral disc degeneration 17.56 10.23 80 219772 7287 42394196
Bronchiolitis 17.45 10.23 52 219800 3854 42397629
Squamous cell carcinoma of lung 17.44 10.23 37 219815 2219 42399264
Hypoxia 17.43 10.23 254 219598 69532 42331951
Upper respiratory tract infection 17.36 10.23 310 219542 41863 42359620
Arthritis bacterial 17.31 10.23 68 219784 5800 42395683
Hydrocele 17.30 10.23 40 219812 2543 42398940
Cleft lip 17.28 10.23 14 219838 314 42401169
Joint ankylosis 17.22 10.23 31 219821 1646 42399837
Alcohol poisoning 17.13 10.23 81 219771 7493 42393990
Limb reduction defect 17.13 10.23 14 219838 318 42401165
Cerebral haemorrhage 17.12 10.23 124 219728 38842 42362641
Ear infection 17.12 10.23 119 219733 12685 42388798
Lacrimal disorder 17.05 10.23 14 219838 320 42401163
Cytomegalovirus viraemia 17.03 10.23 17 219835 10360 42391123
Rhinitis 17.02 10.23 113 219739 11864 42389619
Atopy 17.00 10.23 23 219829 952 42400531
Vitamin B12 deficiency 16.99 10.23 60 219792 4862 42396621
Congenital bladder anomaly 16.93 10.23 13 219839 269 42401214
Septic arthritis staphylococcal 16.83 10.23 17 219835 512 42400971
Neurological symptom 16.82 10.23 16 219836 9975 42391508
Pulmonary fibrosis 16.80 10.23 211 219641 26470 42375013
Weight decrease neonatal 16.80 10.23 14 219838 327 42401156
Anti-cyclic citrullinated peptide antibody positive 16.72 10.23 33 219819 1879 42399604
Device leakage 16.71 10.23 17 219835 10268 42391215
Sexual dysfunction 16.69 10.23 7 219845 6768 42394715
Haemangioma congenital 16.56 10.23 17 219835 522 42400961
Accidental exposure to product 16.56 10.23 52 219800 20341 42381142
Weight increased 16.55 10.23 698 219154 107285 42294198
Mite allergy 16.55 10.23 3 219849 5043 42396440
Granuloma skin 16.49 10.23 25 219827 1150 42400333
Otitis media 16.43 10.23 49 219803 3634 42397849
Pectus excavatum 16.41 10.23 12 219840 230 42401253
Incorrect route of product administration 16.40 10.23 67 219785 24238 42377245
Hypertelorism 16.32 10.23 18 219834 601 42400882
Neck mass 16.26 10.23 32 219820 1818 42399665
Patent ductus arteriosus 16.22 10.23 47 219805 3429 42398054
Back disorder 16.02 10.23 79 219773 7435 42394048
Hepatic steatosis 15.89 10.23 175 219677 21273 42380210
Heart rate irregular 15.82 10.23 139 219713 15911 42385572
Myoclonus 15.70 10.23 41 219811 17024 42384459
Sinusitis 15.54 10.23 336 219516 46956 42354527
Neoplasm progression 15.45 10.23 87 219765 28913 42372570
Loss of consciousness 15.29 10.23 361 219491 91993 42309490
Red blood cell sedimentation rate abnormal 15.22 10.23 49 219803 3787 42397696
Chronic graft versus host disease 15.21 10.23 6 219846 6019 42395464
Spondyloarthropathy 15.09 10.23 21 219831 893 42400590
Nephropathy toxic 15.08 10.23 41 219811 16797 42384686
Hypertriglyceridaemia 15.06 10.23 18 219834 10108 42391375
Bone cyst 15.05 10.23 29 219823 1622 42399861
Bursitis 15.03 10.23 68 219784 6176 42395307
Neutropenia neonatal 14.98 10.23 21 219831 899 42400584
Posterior reversible encephalopathy syndrome 14.95 10.23 27 219825 12794 42388689
Pruritus 14.86 10.23 809 219043 187962 42213521
Constipation 14.80 10.23 685 219167 161606 42239877
Abortion spontaneous 14.75 10.23 14 219838 390 42401093
Red blood cell count decreased 14.74 10.23 244 219608 32471 42369012
Pulmonary pain 14.73 10.23 28 219824 1550 42399933
Immunosuppression 14.69 10.23 84 219768 8369 42393114
Microangiopathy 14.67 10.23 29 219823 1653 42399830
Acute respiratory distress syndrome 14.62 10.23 93 219759 30015 42371468
Juvenile idiopathic arthritis 14.62 10.23 38 219814 2601 42398882
Ascites 14.61 10.23 205 219647 56473 42345010
Skin injury 14.61 10.23 38 219814 2603 42398880
Carcinoid tumour of the small bowel 14.61 10.23 14 219838 395 42401088
Cytomegalovirus chorioretinitis 14.57 10.23 3 219849 4608 42396875
Dermatitis atopic 14.57 10.23 26 219826 12378 42389105
Lung cancer metastatic 14.55 10.23 41 219811 2945 42398538
Exposure via skin contact 14.50 10.23 4 219848 5034 42396449
Colorectal cancer 14.50 10.23 4 219848 5034 42396449
Injection site haemorrhage 14.49 10.23 107 219745 11629 42389854
Asphyxia 14.41 10.23 13 219839 8313 42393170
Dysstasia 14.41 10.23 123 219729 13963 42387520
Oesophageal fibrosis 14.40 10.23 10 219842 176 42401307
Glycosylated haemoglobin increased 14.38 10.23 28 219824 12896 42388587
Electrocardiogram QRS complex prolonged 14.37 10.23 6 219846 5817 42395666
Exposure to toxic agent 14.36 10.23 4 219848 5000 42396483
Disability assessment scale score increased 14.35 10.23 14 219838 404 42401079
C-reactive protein decreased 14.29 10.23 34 219818 2202 42399281
Hernia pain 14.23 10.23 12 219840 285 42401198
Polydactyly 14.22 10.23 24 219828 1210 42400273
Tooth malformation 14.16 10.23 10 219842 181 42401302
Hypertransaminasaemia 14.16 10.23 16 219836 9211 42392272
Agranulocytosis 14.14 10.23 96 219756 30516 42370967
Contusion 14.02 10.23 299 219553 41686 42359797
Melaena 13.96 10.23 130 219722 38616 42362867
Potentiating drug interaction 13.94 10.23 8 219844 6460 42395023
Haematotoxicity 13.85 10.23 22 219830 10963 42390520
Low set ears 13.77 10.23 15 219837 494 42400989
Hypocalcaemia 13.75 10.23 95 219757 30078 42371405
Gastrointestinal infection 13.74 10.23 70 219782 6673 42394810
Mydriasis 13.68 10.23 15 219837 8755 42392728
Obsessive-compulsive disorder 13.62 10.23 9 219843 6734 42394749
Cholelithiasis 13.60 10.23 182 219670 23164 42378319
Haemangioma 13.58 10.23 31 219821 1954 42399529
Foetal distress syndrome 13.58 10.23 23 219829 1163 42400320
Neck pain 13.57 10.23 224 219628 29790 42371693
Attention deficit hyperactivity disorder 13.53 10.23 41 219811 3067 42398416
Urticaria 13.51 10.23 285 219567 73751 42327732
Blister infected 13.41 10.23 15 219837 509 42400974
Scoliosis 13.39 10.23 41 219811 3085 42398398
Haemoptysis 13.36 10.23 163 219689 46004 42355479
Autoscopy 13.34 10.23 11 219841 253 42401230
Arnold-Chiari malformation 13.33 10.23 13 219839 375 42401108
Mobility decreased 13.30 10.23 256 219596 35050 42366433
Microcephaly 13.29 10.23 20 219832 914 42400569
Maternal exposure timing unspecified 13.27 10.23 13 219839 377 42401106
Thrombotic microangiopathy 13.24 10.23 36 219816 14746 42386737
Hepatitis E antibody positive 13.23 10.23 11 219841 256 42401227
Myasthenia gravis 13.21 10.23 41 219811 16096 42385387
Respiratory rate increased 13.17 10.23 100 219752 10962 42390521
Diverticulum 13.14 10.23 75 219777 7466 42394017
Dystonia 13.14 10.23 29 219823 12761 42388722
Impaired work ability 13.13 10.23 107 219745 11984 42389499
Gangrene neonatal 13.10 10.23 10 219842 205 42401278
Cystitis bacterial 13.06 10.23 10 219842 206 42401277
Respiratory tract infection viral 13.06 10.23 43 219809 3363 42398120
Tinea pedis 12.94 10.23 31 219821 2017 42399466
Psychiatric decompensation 12.83 10.23 3 219849 4219 42397264
Hepatic enzyme increased 12.79 10.23 318 219534 45466 42356017
Infective pulmonary exacerbation of cystic fibrosis 12.61 10.23 13 219839 7805 42393678
Hepatic encephalopathy 12.61 10.23 43 219809 16399 42385084
Rash maculo-papular 12.60 10.23 128 219724 37375 42364108
Diverticular perforation 12.57 10.23 45 219807 3671 42397812
Anaemia vitamin B12 deficiency 12.53 10.23 15 219837 548 42400935
Blood albumin decreased 12.50 10.23 128 219724 15274 42386209
Mania 12.49 10.23 22 219830 10525 42390958
Nephrotic syndrome 12.44 10.23 16 219836 8702 42392781
Anal atresia 12.38 10.23 11 219841 281 42401202
Immunodeficiency 12.38 10.23 72 219780 7218 42394265
Eosinophilic myocarditis 12.37 10.23 24 219828 1349 42400134
Dry throat 12.37 10.23 38 219814 2864 42398619
Pleural fibrosis 12.36 10.23 24 219828 1350 42400133
Developmental coordination disorder 12.35 10.23 10 219842 224 42401259
Hyponatraemia 12.35 10.23 414 219438 101048 42300435
Ligament rupture 12.29 10.23 24 219828 1356 42400127
Pharyngeal disorder 12.23 10.23 19 219833 893 42400590
Educational problem 12.22 10.23 15 219837 563 42400920
Asymptomatic bacteriuria 12.20 10.23 10 219842 228 42401255
Euglycaemic diabetic ketoacidosis 12.20 10.23 7 219845 5653 42395830
Foetal heart rate deceleration abnormality 12.20 10.23 15 219837 564 42400919
Strabismus 12.19 10.23 33 219819 2315 42399168
Drug level increased 12.18 10.23 82 219770 26118 42375365
Bone erosion 12.17 10.23 50 219802 4353 42397130
Skin abrasion 12.14 10.23 78 219774 8097 42393386
Hallucination 12.13 10.23 216 219636 57291 42344192
Vascular insufficiency 12.11 10.23 12 219840 353 42401130
Pharyngitis 12.11 10.23 83 219769 8807 42392676
Lower respiratory tract congestion 12.09 10.23 26 219826 1574 42399909
Fistula 12.07 10.23 76 219776 7836 42393647
Inguinal hernia 12.01 10.23 83 219769 8829 42392654
Tinnitus 12.01 10.23 213 219639 28725 42372758
Blood insulin increased 12.00 10.23 12 219840 357 42401126
Gross motor delay 11.94 10.23 12 219840 359 42401124
Hepatitis E virus test positive 11.87 10.23 11 219841 297 42401186
Mesothelioma 11.84 10.23 13 219839 432 42401051
Disease recurrence 11.83 10.23 97 219755 29581 42371902
Hypermetropia 11.82 10.23 14 219838 506 42400977
Abnormal behaviour 11.70 10.23 84 219768 26367 42375116
Abdominal adhesions 11.69 10.23 27 219825 1715 42399768
Asthma 11.63 10.23 239 219613 62075 42339408
Nephrolithiasis 11.57 10.23 260 219592 36570 42364913
Nail bed bleeding 11.53 10.23 13 219839 445 42401038
Palindromic rheumatism 11.53 10.23 9 219843 191 42401292
Blood folate increased 11.52 10.23 11 219841 309 42401174
Lung opacity 11.51 10.23 8 219844 5829 42395654
Pleuritic pain 11.44 10.23 69 219783 7008 42394475
Psychomotor retardation 11.42 10.23 49 219803 4350 42397133
Mucosal ulceration 11.40 10.23 23 219829 1331 42400152
Latent tuberculosis 11.39 10.23 26 219826 1639 42399844
Disinhibition 11.39 10.23 3 219849 3892 42397591
Vein disorder 11.38 10.23 30 219822 2072 42399411
Nerve compression 11.34 10.23 46 219806 3982 42397501
Disseminated intravascular coagulation 11.33 10.23 78 219774 24716 42376767
Blood test abnormal 11.32 10.23 109 219743 12797 42388686
Hallucination, auditory 11.31 10.23 39 219813 14825 42386658
Poor venous access 11.27 10.23 70 219782 7182 42394301
Congenital hydronephrosis 11.24 10.23 17 219835 780 42400703
Peripheral artery thrombosis 11.20 10.23 35 219817 2662 42398821
Facial pain 11.16 10.23 4 219848 4256 42397227
Rotator cuff syndrome 11.15 10.23 65 219787 6521 42394962
Drug-induced liver injury 11.12 10.23 135 219717 38138 42363345
Tender joint count decreased 11.11 10.23 10 219842 260 42401223
Swollen joint count decreased 11.11 10.23 10 219842 260 42401223
Fever neonatal 11.09 10.23 8 219844 150 42401333
Glomerular filtration rate decreased 11.08 10.23 45 219807 16306 42385177
Arrhythmia 11.05 10.23 144 219708 40173 42361310
Protein deficiency 11.04 10.23 10 219842 262 42401221
Unresponsive to stimuli 11.04 10.23 106 219746 31297 42370186
Complications of transplanted kidney 11.00 10.23 7 219845 5343 42396140
Hypothyroidism 10.99 10.23 109 219743 31975 42369508
Stress ulcer 10.98 10.23 10 219842 264 42401219
Myopia 10.95 10.23 22 219830 1269 42400214
Bronchitis 10.95 10.23 320 219532 46881 42354602
Haemodynamic instability 10.93 10.23 31 219821 12526 42388957
Multiple-drug resistance 10.91 10.23 13 219839 7309 42394174
Dehiscence 10.90 10.23 15 219837 631 42400852
Hepatitis fulminant 10.88 10.23 6 219846 4953 42396530
Anal spasm 10.86 10.23 8 219844 155 42401328
Skin graft failure 10.86 10.23 8 219844 155 42401328
Excessive cerumen production 10.84 10.23 11 219841 333 42401150
Vomiting 10.80 10.23 1319 218533 288404 42113079
Congenital genital malformation 10.78 10.23 8 219844 157 42401326
Palmoplantar pustulosis 10.71 10.23 13 219839 482 42401001
Panniculitis 10.68 10.23 30 219822 2151 42399332
Osteochondrosis 10.67 10.23 23 219829 1395 42400088
Visuospatial deficit 10.65 10.23 7 219845 112 42401371
Ear malformation 10.63 10.23 11 219841 341 42401142
Rectal haemorrhage 10.62 10.23 333 219519 49273 42352210
Diabetes insipidus 10.59 10.23 3 219849 3710 42397773
Psychomotor skills impaired 10.59 10.23 54 219798 5150 42396333
Vitamin B complex deficiency 10.57 10.23 13 219839 489 42400994
Hypophosphataemia 10.53 10.23 64 219788 20881 42380602
Hand fracture 10.53 10.23 36 219816 2870 42398613
Bronchopulmonary aspergillosis 10.50 10.23 58 219794 19371 42382112
Graft versus host disease 10.47 10.23 33 219819 12892 42388591
Product quality issue 10.44 10.23 52 219800 17830 42383653
Necrotising fasciitis streptococcal 10.44 10.23 8 219844 165 42401318
Emphysema 10.40 10.23 100 219752 11735 42389748
Diabetic ketoacidosis 10.40 10.23 70 219782 22297 42379186
Progressive multifocal leukoencephalopathy 10.40 10.23 28 219824 11508 42389975
Nocardiosis 10.38 10.23 7 219845 5183 42396300
Dry mouth 10.36 10.23 144 219708 39735 42361748
Non-Hodgkin's lymphoma 10.35 10.23 23 219829 1424 42400059
End stage renal disease 10.34 10.23 47 219805 16511 42384972
Kyphosis 10.34 10.23 22 219830 1322 42400161
Gait disturbance 10.34 10.23 611 219241 97389 42304094
Nail pitting 10.30 10.23 12 219840 426 42401057
Blood homocysteine increased 10.29 10.23 10 219842 287 42401196
Behaviour disorder 10.29 10.23 67 219785 6987 42394496
Cataract 10.23 10.23 218 219634 30386 42371097
Tooth injury 10.23 10.23 21 219831 1230 42400253

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Systemic lupus erythematosus 1150.59 9.70 4247 795290 250091 109539671
Arthropathy 1111.10 9.70 4568 794969 282954 109506808
Toxicity to various agents 1104.70 9.70 1107 798430 479448 109310314
Synovitis 1075.97 9.70 4376 795161 269716 109520046
Pemphigus 1059.08 9.70 3687 795850 210883 109578879
Completed suicide 1040.64 9.70 238 799299 242143 109547619
Hand deformity 1039.21 9.70 3709 795828 214797 109574965
Joint swelling 974.48 9.70 5999 793538 436846 109352916
Glossodynia 955.60 9.70 3649 795888 218355 109571407
Wound 830.33 9.70 3628 795909 230809 109558953
Anti-cyclic citrullinated peptide antibody positive 829.41 9.70 3047 796490 178937 109610825
Rheumatoid arthritis 802.29 9.70 4278 795259 295335 109494427
Pericarditis 792.88 9.70 3413 796124 215701 109574061
Drug abuse 792.48 9.70 159 799378 177252 109612510
Drug interaction 740.59 9.70 1568 797969 498615 109291147
Infusion related reaction 734.69 9.70 4995 794542 376167 109413595
Maternal exposure during pregnancy 730.39 9.70 3709 795828 251174 109538588
Duodenal ulcer perforation 712.66 9.70 2857 796680 174843 109614919
Abdominal discomfort 698.53 9.70 5058 794479 388800 109400962
Arthralgia 687.90 9.70 8629 790908 771003 109018759
Helicobacter infection 672.53 9.70 2852 796685 179025 109610737
Swelling 656.06 9.70 4566 794971 346475 109443287
Alopecia 619.69 9.70 4637 794900 360116 109429646
Psoriatic arthropathy 618.32 9.70 2940 796597 193821 109595941
Therapeutic product effect decreased 592.58 9.70 3397 796140 240919 109548843
Intentional overdose 564.76 9.70 132 799405 132369 109657393
Death 549.96 9.70 2892 796645 695977 109093785
Pain 540.94 9.70 9797 789740 945158 108844604
Discomfort 537.54 9.70 3011 796526 211696 109578066
Rheumatoid factor positive 524.87 9.70 2113 797424 129527 109660235
Contraindicated product administered 505.92 9.70 3300 796237 244967 109544795
Musculoskeletal stiffness 492.47 9.70 3588 795949 276234 109513528
Impaired healing 486.62 9.70 2750 796787 193967 109595795
Hepatic enzyme increased 477.41 9.70 3957 795580 316935 109472827
Acute kidney injury 462.82 9.70 2697 796840 632733 109157029
Folliculitis 436.15 9.70 2376 797161 165277 109624485
Febrile neutropenia 434.93 9.70 1034 798503 315733 109474029
Nasopharyngitis 418.45 9.70 4526 795011 389835 109399927
Blister 395.05 9.70 2907 796630 224469 109565293
Irritable bowel syndrome 391.22 9.70 2273 797264 161942 109627820
Muscle injury 388.35 9.70 2028 797509 138779 109650983
C-reactive protein abnormal 385.73 9.70 1908 797629 127787 109661975
Drug intolerance 363.58 9.70 4514 795023 401998 109387764
Fibromyalgia 358.57 9.70 2289 797248 168620 109621142
Rheumatic fever 357.23 9.70 1793 797744 120786 109668976
Lower respiratory tract infection 354.02 9.70 2984 796553 240122 109549640
Sleep disorder due to general medical condition, insomnia type 348.13 9.70 1601 797936 104042 109685720
Suicide attempt 339.54 9.70 161 799376 103233 109686529
Disease progression 337.75 9.70 793 798744 243241 109546521
Exposure during pregnancy 336.35 9.70 2218 797319 165206 109624556
Depressed level of consciousness 331.81 9.70 200 799337 112078 109677684
Cardiac arrest 310.18 9.70 594 798943 196159 109593603
Sinusitis 304.34 9.70 3383 796154 293305 109496457
Osteoarthritis 303.08 9.70 2310 797227 180313 109609449
Ill-defined disorder 296.52 9.70 2047 797490 154806 109634956
Malignant neoplasm progression 293.97 9.70 506 799031 174061 109615701
Peripheral swelling 293.91 9.70 4323 795214 399711 109390051
Hypersensitivity 288.94 9.70 4310 795227 399688 109390074
Type 2 diabetes mellitus 275.97 9.70 2209 797328 175023 109614739
Swollen joint count increased 274.24 9.70 1266 798271 82395 109707367
Stomatitis 270.11 9.70 3066 796471 267176 109522586
Weight increased 263.36 9.70 4380 795157 415264 109374498
Sedation 258.89 9.70 90 799447 69593 109720169
Overdose 257.11 9.70 849 798688 232945 109556817
Rhabdomyolysis 253.24 9.70 298 799239 120103 109669659
Inflammation 252.76 9.70 2317 797220 190921 109598841
Lactic acidosis 247.79 9.70 185 799352 92626 109697136
Bradycardia 246.42 9.70 468 799069 155049 109634713
Neutropenia 244.89 9.70 1643 797894 372977 109416785
Multiple organ dysfunction syndrome 238.24 9.70 459 799078 151251 109638511
Treatment failure 237.18 9.70 3054 796483 274180 109515582
Contusion 232.90 9.70 2647 796890 230714 109559048
Hyponatraemia 228.05 9.70 807 798730 216846 109572916
Joint range of motion decreased 226.12 9.70 1583 797954 120249 109669513
Cardiac failure 225.68 9.70 654 798883 186972 109602790
Coma 222.86 9.70 316 799221 117553 109672209
Facet joint syndrome 221.31 9.70 1326 798211 95502 109694260
Hepatic function abnormal 217.27 9.70 195 799342 89100 109700662
Serotonin syndrome 215.32 9.70 79 799458 59074 109730688
Constipation 214.40 9.70 1609 797928 356177 109433585
Sickle cell anaemia with crisis 214.33 9.70 303 799234 9242 109780520
Red blood cell sedimentation rate abnormal 213.87 9.70 517 799020 23992 109765770
Hypotension 213.26 9.70 2592 796945 521257 109268505
Respiratory failure 211.45 9.70 820 798717 214512 109575250
Drug resistance 210.83 9.70 72 799465 56302 109733460
Electrocardiogram QT prolonged 208.11 9.70 290 799247 108670 109681092
Myelosuppression 206.55 9.70 226 799311 94114 109695648
Renal impairment 204.64 9.70 688 798849 187757 109602005
Drug reaction with eosinophilia and systemic symptoms 203.69 9.70 176 799361 81919 109707843
Knee arthroplasty 203.45 9.70 970 798567 63978 109725784
Somnolence 203.24 9.70 1287 798250 296162 109493600
Grip strength decreased 201.51 9.70 1126 798411 79048 109710714
Blood cholesterol increased 200.88 9.70 2132 797405 182653 109607109
Arthritis 196.64 9.70 1964 797573 165622 109624140
Drug ineffective for unapproved indication 196.12 9.70 274 799263 102564 109687198
Renal failure 193.48 9.70 910 798627 225664 109564098
Pregnancy 189.48 9.70 802 798735 50265 109739497
Product use issue 183.30 9.70 3220 796317 308475 109481287
Hip arthroplasty 181.72 9.70 843 798694 54970 109734792
Lip dry 180.22 9.70 1291 798246 98792 109690970
Angioedema 178.47 9.70 272 799265 98228 109691534
Blood pressure systolic abnormal 178.35 9.70 487 799050 24363 109765399
Infection 177.40 9.70 3638 795899 358562 109431200
Agitation 176.64 9.70 343 799194 112708 109677054
Blood pressure fluctuation 175.04 9.70 1031 798506 73793 109715969
Mobility decreased 174.65 9.70 2546 796991 234876 109554886
Respiratory arrest 172.01 9.70 104 799433 58195 109731567
Blood pressure systolic increased 170.56 9.70 1106 798431 81885 109707877
Cytokine release syndrome 170.48 9.70 154 799383 70152 109719610
Hyperhidrosis 169.03 9.70 737 798800 186561 109603201
Intentional product use issue 168.62 9.70 2623 796914 245283 109544479
Blood pressure diastolic abnormal 167.74 9.70 488 799049 25327 109764435
Musculoskeletal pain 167.49 9.70 2042 797495 180981 109608781
Hypoglycaemia 167.27 9.70 369 799168 115735 109674027
Neoplasm progression 167.03 9.70 133 799404 64462 109725300
Sopor 166.83 9.70 31 799506 36515 109753247
Injury 166.25 9.70 1987 797550 175278 109614484
Bursitis 159.93 9.70 1538 797999 128380 109661382
Live birth 157.78 9.70 950 798587 68534 109721228
Altered state of consciousness 156.24 9.70 113 799424 57513 109732249
Intentional product misuse 154.21 9.70 471 799066 132433 109657329
Off label use 152.83 9.70 9088 790449 1491097 108298665
C-reactive protein increased 152.12 9.70 2316 797221 215603 109574159
Cytomegalovirus infection 146.00 9.70 108 799429 54336 109735426
Red blood cell sedimentation rate increased 145.61 9.70 1018 798519 77284 109712478
Deep vein thrombosis postoperative 141.29 9.70 821 798716 58470 109731292
Hepatic failure 139.38 9.70 175 799362 68564 109721198
Abortion spontaneous 138.71 9.70 553 798984 33729 109756033
Sciatica 138.52 9.70 1142 798395 91257 109698505
Cardio-respiratory arrest 138.36 9.70 405 799132 115431 109674331
Sepsis 137.15 9.70 1609 797928 325737 109464025
Hyperglycaemia 135.70 9.70 255 799282 84835 109704927
Tachycardia 135.32 9.70 1020 798517 225625 109564137
Thrombocytopenia 135.18 9.70 1744 797793 347141 109442621
Metabolic acidosis 134.83 9.70 328 799209 99416 109690346
Neuropathy peripheral 133.84 9.70 754 798783 178523 109611239
Gastrointestinal disorder 133.19 9.70 2474 797063 239478 109550284
Wound infection 132.88 9.70 1170 798367 95295 109694467
Obesity 132.73 9.70 1328 798209 112023 109677739
Breast cancer stage III 131.85 9.70 1002 798535 78115 109711647
Liver injury 131.08 9.70 1663 797874 148750 109641012
Shock 128.01 9.70 119 799418 53469 109736293
Drug dependence 126.83 9.70 105 799432 49915 109739847
Hypoxia 125.31 9.70 496 799041 129019 109660743
Peripheral venous disease 125.21 9.70 1038 798499 83079 109706683
Joint effusion 124.30 9.70 383 799154 20522 109769240
Intentional self-injury 121.77 9.70 59 799478 37370 109752392
Respiratory depression 121.18 9.70 40 799497 31961 109757801
Ventricular fibrillation 120.07 9.70 75 799462 41238 109748524
Product use in unapproved indication 119.35 9.70 2398 797139 444979 109344783
Anaphylactic shock 119.01 9.70 118 799419 51428 109738334
Cognitive disorder 116.53 9.70 290 799247 87221 109702541
Syncope 116.44 9.70 921 798616 201615 109588147
Autoimmune disorder 114.60 9.70 839 798698 64644 109725118
Pain in extremity 114.06 9.70 4453 795084 482665 109307097
Foot deformity 114.02 9.70 669 798868 47811 109741951
Psoriasis 113.28 9.70 1527 798010 138466 109651296
Hyperkalaemia 113.20 9.70 550 798987 135246 109654516
Anaemia 112.82 9.70 3051 796486 544035 109245727
Ventricular tachycardia 112.59 9.70 117 799420 49892 109739870
Joint stiffness 111.70 9.70 851 798686 66392 109723370
Condition aggravated 110.62 9.70 6429 793108 728407 109061355
Palmar-plantar erythrodysaesthesia syndrome 109.21 9.70 82 799455 40943 109748819
Seizure 108.88 9.70 1047 798490 220138 109569624
Bone erosion 105.91 9.70 635 798902 45736 109744026
Disability assessment scale score increased 105.57 9.70 142 799395 4128 109785634
Road traffic accident 104.70 9.70 1213 798324 106185 109683577
Cardiogenic shock 103.22 9.70 159 799378 57179 109732583
Drug use disorder 103.19 9.70 7 799530 18067 109771695
Neurotoxicity 102.87 9.70 92 799445 42115 109747647
Encephalopathy 101.51 9.70 277 799260 80778 109708984
Poisoning 100.76 9.70 42 799495 29063 109760699
Ascites 100.60 9.70 339 799198 92469 109697293
Suicidal ideation 100.55 9.70 345 799192 93592 109696170
Rash 100.31 9.70 7055 792482 813909 108975853
Gait inability 99.65 9.70 1461 798076 134915 109654847
Sedation complication 99.34 9.70 13 799524 19842 109769920
Tremor 99.23 9.70 958 798579 201274 109588488
No adverse event 98.08 9.70 245 799292 73594 109716168
Blood pressure diastolic decreased 96.90 9.70 514 799023 35371 109754391
Osteoporosis 95.80 9.70 1008 798529 86144 109703618
Neutrophil count decreased 95.57 9.70 499 799038 120442 109669320
Myalgia 95.46 9.70 1087 798450 221294 109568468
Cerebral haemorrhage 94.78 9.70 205 799332 64763 109724999
Disseminated intravascular coagulation 94.75 9.70 95 799442 41191 109748571
Hepatocellular injury 94.49 9.70 137 799400 50505 109739257
General physical health deterioration 94.20 9.70 3865 795672 421430 109368332
Acute hepatic failure 93.14 9.70 76 799461 36392 109753370
Blood creatinine increased 92.88 9.70 859 798678 182030 109607732
Fatigue 92.76 9.70 10091 789446 1205867 108583895
Suspected suicide 92.64 9.70 4 799533 15195 109774567
Dehydration 92.05 9.70 1443 798094 278068 109511694
Restlessness 92.01 9.70 166 799371 56093 109733669
Blood creatine phosphokinase increased 91.31 9.70 250 799287 72827 109716935
Neuroleptic malignant syndrome 90.76 9.70 68 799469 33991 109755771
Leukopenia 90.51 9.70 666 798871 148125 109641637
Injection site reaction 90.43 9.70 1014 798523 88056 109701706
Hypokalaemia 90.05 9.70 863 798674 181585 109608177
Hypoaesthesia 89.10 9.70 2936 796601 311287 109478475
Nausea 89.03 9.70 7709 791828 1227981 108561781
Enthesopathy 89.01 9.70 244 799293 12234 109777528
Pulmonary fibrosis 88.79 9.70 1128 798409 100914 109688848
Lower limb fracture 88.79 9.70 884 798653 74464 109715298
Mydriasis 88.77 9.70 25 799512 22132 109767630
Heart rate decreased 88.55 9.70 952 798585 81804 109707958
Adverse event 88.49 9.70 1188 798349 107621 109682141
Cardiac failure congestive 87.08 9.70 686 798851 150314 109639448
Orthostatic hypotension 87.07 9.70 221 799316 66028 109723734
Disturbance in attention 86.06 9.70 201 799336 61794 109727968
Adjustment disorder with depressed mood 84.82 9.70 576 798961 43307 109746455
Chest discomfort 84.67 9.70 825 798712 173023 109616739
Hypercholesterolaemia 84.58 9.70 1017 798520 89820 109699942
Wrong technique in product usage process 84.18 9.70 335 799202 87013 109702749
Polyarthritis 83.33 9.70 314 799223 18649 109771113
Hallucination 83.27 9.70 413 799124 101019 109688743
Dry skin 82.93 9.70 448 799089 107205 109682557
Dislocation of vertebra 82.80 9.70 571 798966 43150 109746612
Dry mouth 81.52 9.70 1957 797580 197991 109591771
Atrial fibrillation 81.30 9.70 1169 798368 228473 109561289
Myocardial infarction 81.22 9.70 942 798595 191141 109598621
Post transplant lymphoproliferative disorder 81.12 9.70 9 799528 15604 109774158
Aspergillus infection 80.89 9.70 42 799495 25574 109764188
Myoclonus 80.33 9.70 72 799465 32926 109756836
Joint destruction 79.07 9.70 215 799322 10728 109779034
Cholestasis 78.92 9.70 223 799314 64295 109725467
Rheumatoid nodule 78.61 9.70 323 799214 19973 109769789
Platelet count decreased 78.48 9.70 1182 798355 229261 109560501
Venoocclusive liver disease 78.43 9.70 9 799528 15198 109774564
Juvenile idiopathic arthritis 78.13 9.70 149 799388 5858 109783904
Drug withdrawal syndrome 78.07 9.70 96 799441 37958 109751804
Appendicolith 77.24 9.70 7 799530 14248 109775514
Thrombotic microangiopathy 76.64 9.70 59 799478 29090 109760672
Aggression 75.91 9.70 200 799337 59010 109730752
Withdrawal syndrome 75.76 9.70 69 799468 31311 109758451
Therapy partial responder 75.50 9.70 94 799443 36967 109752795
Vision blurred 75.40 9.70 584 798953 128438 109661324
Blood glucose increased 74.98 9.70 605 798932 131891 109657871
C-reactive protein 74.22 9.70 423 799114 29908 109759854
Proteinuria 73.94 9.70 109 799428 39909 109749853
Accidental exposure to product 73.61 9.70 157 799380 49851 109739911
Disorientation 73.32 9.70 263 799274 70408 109719354
Pulmonary alveolar haemorrhage 73.18 9.70 27 799510 20123 109769639
Temperature regulation disorder 73.13 9.70 5 799532 12821 109776941
Dysphagia 73.09 9.70 733 798804 152867 109636895
Akathisia 72.99 9.70 17 799520 17096 109772666
Torsade de pointes 72.95 9.70 36 799501 22564 109767198
Forced expiratory volume decreased 72.68 9.70 6 799531 13170 109776592
Night sweats 72.63 9.70 1367 798170 132616 109657146
BK virus infection 72.20 9.70 6 799531 13100 109776662
Cerebral infarction 72.01 9.70 168 799369 51670 109738092
Anaphylactic reaction 71.75 9.70 507 799030 113793 109675969
Ejection fraction decreased 71.08 9.70 116 799421 40764 109748998
Cytomegalovirus infection reactivation 71.04 9.70 22 799515 18311 109771451
Miosis 70.98 9.70 35 799502 21948 109767814
Dysarthria 69.93 9.70 341 799196 83780 109705982
Skin exfoliation 69.61 9.70 361 799176 87290 109702472
Pathogen resistance 68.85 9.70 21 799516 17651 109772111
White blood cell count decreased 68.70 9.70 1205 798332 228185 109561577
Bronchopulmonary aspergillosis 68.21 9.70 69 799468 29794 109759968
Diabetic ketoacidosis 67.97 9.70 125 799412 41933 109747829
Haemoptysis 67.91 9.70 275 799262 71079 109718683
Exposure to toxic agent 67.86 9.70 7 799530 12851 109776911
Drug level increased 67.62 9.70 153 799384 47566 109742196
Sleep disorder 67.51 9.70 1898 797639 196746 109593016
Respiratory distress 67.10 9.70 263 799274 68611 109721151
Gamma-glutamyltransferase increased 67.09 9.70 223 799314 61086 109728676
Tenosynovitis 66.95 9.70 264 799273 16019 109773743
Hypothermia 66.94 9.70 55 799482 26247 109763515
Disease recurrence 66.58 9.70 221 799316 60563 109729199
Onychomycosis 66.45 9.70 492 799045 38039 109751723
Blood pressure diastolic increased 66.40 9.70 291 799246 18516 109771246
Loss of consciousness 66.12 9.70 1009 798528 195297 109594465
Onychomadesis 66.09 9.70 560 798977 45103 109744659
Dyspnoea 65.68 9.70 7004 792533 1099868 108689894
Immune reconstitution inflammatory syndrome 65.58 9.70 18 799519 16208 109773554
Substance abuse 65.22 9.70 7 799530 12456 109777306
Posterior reversible encephalopathy syndrome 64.76 9.70 90 799447 33771 109755991
Balance disorder 64.69 9.70 535 799002 116025 109673737
Haematotoxicity 64.48 9.70 36 799501 21046 109768716
Extrapyramidal disorder 64.46 9.70 68 799469 28799 109760963
Finger deformity 64.34 9.70 435 799102 32657 109757105
Caesarean section 64.24 9.70 233 799304 13584 109776178
Creatinine renal clearance decreased 64.23 9.70 39 799498 21776 109767986
Laryngitis 63.99 9.70 525 799012 41886 109747876
Body temperature decreased 63.91 9.70 472 799065 36463 109753299
Unresponsive to stimuli 63.81 9.70 241 799296 63549 109726213
Abnormal behaviour 63.12 9.70 116 799421 38923 109750839
Acute graft versus host disease 63.10 9.70 9 799528 12872 109776890
Asphyxia 62.90 9.70 13 799524 14202 109775560
Blepharospasm 61.50 9.70 637 798900 54214 109735548
Joint laxity 61.42 9.70 83 799454 2424 109787338
Melaena 61.12 9.70 272 799265 68485 109721277
Psychotic disorder 60.88 9.70 178 799359 50759 109739003
Arrhythmia 60.79 9.70 277 799260 69298 109720464
Acute respiratory distress syndrome 60.65 9.70 190 799347 53008 109736754
Hemiplegia 60.04 9.70 46 799491 22736 109767026
Oedema 59.23 9.70 1961 797576 208015 109581747
Localised infection 59.20 9.70 522 799015 42526 109747236
Loss of personal independence in daily activities 58.93 9.70 1461 798076 148559 109641203
Wheezing 58.88 9.70 2330 797207 252900 109536862
Irritability 58.66 9.70 165 799372 47644 109742118
Interstitial lung disease 58.63 9.70 684 798853 138650 109651112
Mucormycosis 58.18 9.70 5 799532 10623 109779139
X-ray abnormal 58.13 9.70 473 799064 37644 109752118
Lung disorder 57.51 9.70 1707 797830 178340 109611422
Dystonia 57.38 9.70 61 799476 25744 109764018
Lupus-like syndrome 57.33 9.70 497 799040 40295 109749467
Brain oedema 57.16 9.70 85 799452 31013 109758749
Rebound effect 56.96 9.70 18 799519 14788 109774974
Exostosis 56.50 9.70 544 798993 45412 109744350
Status epilepticus 56.39 9.70 88 799449 31483 109758279
Personality disorder 56.27 9.70 12 799525 12825 109776937
Exposure via skin contact 56.19 9.70 13 799524 13134 109776628
Inappropriate antidiuretic hormone secretion 56.15 9.70 99 799438 33752 109756010
Ear infection 56.08 9.70 697 798840 62035 109727727
Pulmonary oedema 55.86 9.70 462 799075 100197 109689565
Aphasia 55.75 9.70 228 799309 58769 109730993
Toxic epidermal necrolysis 55.65 9.70 216 799321 56511 109733251
Eosinophilia 55.32 9.70 223 799314 57713 109732049
Anti-cyclic citrullinated peptide antibody 55.31 9.70 288 799249 19676 109770086
Gestational diabetes 55.22 9.70 147 799390 7242 109782520
Neurologic neglect syndrome 54.90 9.70 3 799534 9295 109780467
Graft versus host disease 54.85 9.70 34 799503 18772 109770990
Retinitis 54.74 9.70 411 799126 31916 109757846
Psychomotor hyperactivity 54.65 9.70 40 799497 20237 109769525
Second primary malignancy 53.62 9.70 32 799505 18036 109771726
Pancreatitis acute 53.24 9.70 239 799298 60035 109729727
Dyskinesia 53.00 9.70 192 799345 51254 109738508
Unintentional medical device removal 52.31 9.70 3 799534 8920 109780842
Clostridium difficile colitis 52.31 9.70 153 799384 43625 109746137
Speech disorder 52.09 9.70 248 799289 61321 109728441
Coagulopathy 51.83 9.70 139 799398 40772 109748990
Drug dose omission by device 51.80 9.70 20 799517 14496 109775266
Haemophagocytic lymphohistiocytosis 51.71 9.70 93 799444 31466 109758296
Bronchospasm 51.47 9.70 87 799450 30152 109759610
Transplant rejection 51.43 9.70 61 799476 24506 109765256
Lupus vulgaris 51.42 9.70 420 799117 33463 109756299
Basal cell carcinoma 51.35 9.70 527 799010 44743 109745019
Hepatic cirrhosis 50.38 9.70 727 798810 66899 109722863
Palpitations 50.36 9.70 828 798709 158384 109631378
COVID-19 50.32 9.70 1367 798170 243693 109546069
Tumour lysis syndrome 50.26 9.70 91 799446 30710 109759052
Pulmonary embolism 49.77 9.70 1175 798362 213299 109576463
Osteonecrosis of jaw 49.61 9.70 179 799358 47838 109741924
Dermatitis atopic 48.73 9.70 68 799469 25473 109764289
Acute respiratory failure 48.62 9.70 331 799206 74929 109714833
Hypothyroidism 48.41 9.70 318 799219 72581 109717181
Blood calcium decreased 48.33 9.70 118 799419 35727 109754035
Tachypnoea 48.30 9.70 136 799401 39259 109750503
Cytopenia 48.23 9.70 90 799447 30026 109759736
Angina pectoris 48.11 9.70 259 799278 62036 109727726
Nail disorder 48.11 9.70 635 798902 57300 109732462
Cytomegalovirus viraemia 47.93 9.70 35 799502 17729 109772033
Joint dislocation 47.75 9.70 416 799121 33774 109755988
Hallucination, visual 47.62 9.70 138 799399 39467 109750295
Diarrhoea 47.38 9.70 7375 792162 1132130 108657632
Polyomavirus-associated nephropathy 47.34 9.70 3 799534 8198 109781564
Septic shock 47.31 9.70 827 798710 156701 109633061
Acute graft versus host disease in skin 47.16 9.70 10 799527 10730 109779032
Rash erythematous 47.06 9.70 372 799165 81460 109708302
Face oedema 46.86 9.70 108 799429 33361 109756401
Adenovirus infection 46.73 9.70 11 799526 10983 109778779
Chronic kidney disease 46.62 9.70 341 799196 75950 109713812
Carotid artery thrombosis 46.60 9.70 7 799530 9631 109780131
Mania 46.42 9.70 49 799488 20747 109769015
Maternal exposure timing unspecified 46.24 9.70 285 799252 20728 109769034
Prescribed overdose 46.23 9.70 890 798647 86691 109703071
Acute chest syndrome 46.10 9.70 66 799471 2037 109787725
Hypomagnesaemia 46.07 9.70 252 799285 60118 109729644
Muscle rigidity 45.83 9.70 64 799473 23967 109765795
Blood alkaline phosphatase increased 45.82 9.70 312 799225 70623 109719139
Blood bilirubin increased 45.74 9.70 341 799196 75631 109714131
Hypophosphataemia 45.72 9.70 108 799429 33074 109756688
Gastrointestinal haemorrhage 45.63 9.70 882 798655 164636 109625126
Red blood cell sedimentation rate 45.50 9.70 110 799427 5104 109784658
Hemiparesis 45.13 9.70 164 799373 43739 109746023
Stevens-Johnson syndrome 45.11 9.70 180 799357 46721 109743041
Cerebrovascular accident 44.94 9.70 983 798554 180301 109609461
Mental status changes 44.73 9.70 344 799193 75778 109713984
Graft versus host disease in gastrointestinal tract 44.56 9.70 6 799531 8962 109780800
Coordination abnormal 44.41 9.70 71 799466 25157 109764605
Tendonitis 44.38 9.70 332 799205 25751 109764011
Metastases to central nervous system 44.29 9.70 60 799477 22757 109767005
Haemorrhage intracranial 44.28 9.70 89 799448 28880 109760882
Lymphocyte count decreased 44.20 9.70 238 799299 57005 109732757
Metastases to bone 44.11 9.70 101 799436 31271 109758491
Bradyphrenia 43.81 9.70 15 799522 11713 109778049
Device difficult to use 43.46 9.70 43 799494 18762 109771000
Pleural effusion 43.37 9.70 966 798571 176743 109613019
Maternal exposure before pregnancy 43.10 9.70 133 799404 7132 109782630
Rash maculo-papular 42.87 9.70 337 799200 73885 109715877
Injection site erythema 42.47 9.70 935 798602 93241 109696521
Wheelchair user 42.35 9.70 139 799398 7703 109782059
Agranulocytosis 42.24 9.70 267 799270 61493 109728269
Colitis ulcerative 42.15 9.70 790 798747 76573 109713189
Hyperbilirubinaemia 42.12 9.70 100 799437 30571 109759191
Ischaemic stroke 41.85 9.70 155 799382 41108 109748654
Prescribed underdose 41.77 9.70 683 798854 64491 109725271
Drug tolerance decreased 41.59 9.70 341 799196 27199 109762563
Paradoxical drug reaction 41.38 9.70 10 799527 9807 109779955
Alanine aminotransferase abnormal 41.38 9.70 155 799382 9179 109780583
Blood pressure decreased 41.37 9.70 584 798953 114507 109675255
Metastases to liver 41.32 9.70 125 799412 35261 109754501
Hyperthermia 41.22 9.70 56 799481 21216 109768546
Coronary artery disease 41.17 9.70 326 799211 71364 109718398
Flushing 41.08 9.70 522 799015 104214 109685548
Acute generalised exanthematous pustulosis 41.01 9.70 58 799479 21606 109768156
Cardiomyopathy 40.91 9.70 116 799421 33409 109756353
Leukocytosis 40.90 9.70 225 799312 53603 109736159
Urinary retention 40.89 9.70 315 799222 69368 109720394
Cardiotoxicity 40.89 9.70 37 799500 16844 109772918
Back injury 40.81 9.70 523 799014 46876 109742886
Muscle twitching 40.79 9.70 98 799439 29837 109759925
Haemorrhage 40.28 9.70 536 799001 106156 109683606
Tongue disorder 40.12 9.70 207 799330 14091 109775671
Depressed mood 40.00 9.70 266 799271 60543 109729219
Sinus tachycardia 39.55 9.70 176 799361 44317 109745445
Emotional distress 39.50 9.70 178 799359 44669 109745093
Glycosylated haemoglobin increased 39.24 9.70 69 799468 23550 109766212
Appendicitis 38.93 9.70 93 799444 28371 109761391
Premature labour 38.76 9.70 150 799387 9022 109780740
Generalised tonic-clonic seizure 38.64 9.70 234 799303 54446 109735316
Parkinsonism 38.54 9.70 63 799474 22124 109767638
Multiple-drug resistance 38.50 9.70 24 799513 13211 109776551
Toxic skin eruption 38.35 9.70 89 799448 27426 109762336
Blood phosphorus increased 38.19 9.70 37 799500 16303 109773459
Multiple sclerosis relapse 38.18 9.70 210 799327 50030 109739732
Neck deformity 38.17 9.70 57 799480 1829 109787933
Myocarditis 38.16 9.70 102 799435 29953 109759809
Bacteraemia 38.09 9.70 167 799370 42223 109747539
Femur fracture 38.01 9.70 490 799047 43979 109745783
Disability 37.77 9.70 359 799178 29864 109759898
Tardive dyskinesia 37.63 9.70 26 799511 13553 109776209
Fluid retention 37.37 9.70 469 799068 93838 109695924
Chronic graft versus host disease 37.28 9.70 11 799526 9446 109780316
Acidosis 37.27 9.70 66 799471 22465 109767297
Nodule 37.07 9.70 380 799157 32251 109757511
Fracture 36.94 9.70 306 799231 24482 109765280
Haematoma 36.88 9.70 259 799278 58217 109731545
Epstein-Barr virus infection 36.65 9.70 49 799488 18689 109771073
Aspartate aminotransferase increased 36.61 9.70 878 798659 159058 109630704
Shock haemorrhagic 36.50 9.70 90 799447 27157 109762605
Premature rupture of membranes 36.44 9.70 94 799443 4543 109785219
Motor dysfunction 36.44 9.70 76 799461 24330 109765432
Tenderness 35.96 9.70 348 799189 29089 109760673
Injection site pruritus 35.81 9.70 545 798992 50713 109739049
Dyspepsia 35.70 9.70 1706 797831 189259 109600503
Fear 35.67 9.70 71 799466 23122 109766640
Erythema multiforme 35.63 9.70 61 799476 21036 109768726
Glomerular filtration rate decreased 35.47 9.70 100 799437 28856 109760906
Potentiating drug interaction 35.44 9.70 20 799517 11623 109778139
Eating disorder 35.32 9.70 110 799427 30748 109759014
Synovial cyst 35.27 9.70 170 799367 11260 109778502
Infective pulmonary exacerbation of cystic fibrosis 35.04 9.70 33 799504 14738 109775024
Nocardiosis 34.93 9.70 6 799531 7480 109782282
Skin haemorrhage 34.85 9.70 80 799457 24747 109765015
Latent tuberculosis 34.81 9.70 84 799453 3893 109785869
Device expulsion 34.74 9.70 111 799426 30780 109758982
Electrocardiogram QRS complex prolonged 34.69 9.70 26 799511 12995 109776767
Vomiting 34.52 9.70 5924 793613 904751 108885011
Ankylosing spondylitis 34.51 9.70 212 799325 15400 109774362
Obstructive airways disorder 34.47 9.70 194 799343 45955 109743807
Haemodynamic instability 34.41 9.70 71 799466 22817 109766945
Acute myeloid leukaemia 34.33 9.70 150 799387 37960 109751802
Feeling abnormal 34.05 9.70 1020 798517 179691 109610071
Bone pain 33.88 9.70 304 799233 64829 109724933
Respiratory acidosis 33.86 9.70 30 799507 13796 109775966
Seronegative arthritis 33.72 9.70 186 799351 12991 109776771
Smear cervix abnormal 33.72 9.70 66 799471 2646 109787116
Pneumonia aspiration 33.69 9.70 400 799137 80833 109708929
Klebsiella infection 33.66 9.70 58 799479 19951 109769811
Diabetes insipidus 33.60 9.70 4 799533 6566 109783196
Device leakage 33.43 9.70 40 799497 16008 109773754
Acute myocardial infarction 33.43 9.70 416 799121 83361 109706401
Stress cardiomyopathy 33.35 9.70 39 799498 15767 109773995
Subdural haematoma 33.13 9.70 143 799394 36311 109753451
Cystitis haemorrhagic 33.02 9.70 24 799513 12185 109777577
Blood parathyroid hormone decreased 32.99 9.70 184 799353 12905 109776857
Tuberculosis 32.98 9.70 231 799306 17543 109772219
Mental disorder 32.96 9.70 156 799381 38635 109751127
Hepatic encephalopathy 32.86 9.70 100 799437 28156 109761606
Nephropathy toxic 32.85 9.70 96 799441 27382 109762380
Arthritis infective 32.82 9.70 156 799381 10273 109779489
Dissociation 32.81 9.70 15 799522 9827 109779935
Pseudomonas infection 32.80 9.70 98 799439 27755 109762007
Hepatitis B reactivation 32.79 9.70 7 799530 7477 109782285
Cardiac failure acute 32.67 9.70 79 799458 23999 109765763
Polyneuropathy 32.63 9.70 120 799417 31892 109757870
Migraine 32.63 9.70 1536 798001 170116 109619646
Food allergy 32.49 9.70 59 799478 19889 109769873
Sinus bradycardia 32.42 9.70 107 799430 29376 109760386
Liver disorder 32.42 9.70 1297 798240 140946 109648816
Dust allergy 32.37 9.70 3 799534 5998 109783764
Adjustment disorder 32.20 9.70 19 799518 10776 109778986
Neck mass 32.15 9.70 92 799445 4729 109785033
Granuloma skin 32.11 9.70 164 799373 11119 109778643
Spinal stenosis 32.11 9.70 242 799295 18814 109770948
End stage renal disease 31.95 9.70 67 799470 21406 109768356
Scleritis 31.94 9.70 99 799438 5321 109784441
Frequent bowel movements 31.94 9.70 708 798829 70682 109719080
Anxiety 31.94 9.70 2107 797430 342971 109446791
Metastases to lung 31.83 9.70 75 799462 22988 109766774
Labelled drug-drug interaction medication error 31.77 9.70 107 799430 29195 109760567
Sexual dysfunction 31.71 9.70 11 799526 8519 109781243
Skin ulcer 31.65 9.70 641 798896 63004 109726758
Hyperuricaemia 31.59 9.70 35 799502 14496 109775266
Candida infection 31.58 9.70 210 799327 47799 109741963
Product prescribing error 31.57 9.70 229 799308 51102 109738660
Oliguria 31.46 9.70 54 799483 18603 109771159
Pre-eclampsia 31.42 9.70 135 799402 8515 109781247
Conjunctivitis allergic 31.38 9.70 6 799531 6925 109782837
Anuria 31.37 9.70 82 799455 24259 109765503
Blood lactic acid increased 31.32 9.70 41 799496 15780 109773982
Pulmonary vasculitis 31.18 9.70 5 799532 6555 109783207
Lethargy 30.80 9.70 483 799054 93093 109696669
Generalised oedema 30.71 9.70 116 799421 30588 109759174
Cyanosis 30.63 9.70 111 799426 29630 109760132
Delusion 30.63 9.70 80 799457 23675 109766087
Multiple fractures 30.56 9.70 137 799400 8803 109780959
Limb deformity 30.54 9.70 77 799460 3669 109786093
Pneumothorax 30.51 9.70 141 799396 35144 109754618
Acute coronary syndrome 30.44 9.70 77 799460 23035 109766727
Weight decreased 30.33 9.70 3846 795691 464211 109325551
Cardiac failure chronic 30.32 9.70 33 799504 13778 109775984
Antinuclear antibody positive 30.22 9.70 139 799398 9029 109780733
Colorectal cancer 30.21 9.70 14 799523 9100 109780662
Ileus 30.15 9.70 117 799420 30612 109759150
Hepatitis acute 30.12 9.70 56 799481 18710 109771052
Graft versus host disease in skin 30.08 9.70 11 799526 8243 109781519
Device use error 30.07 9.70 14 799523 9075 109780687
Pulmonary arterial hypertension 30.06 9.70 127 799410 32441 109757321
Euglycaemic diabetic ketoacidosis 29.96 9.70 24 799513 11599 109778163
Jaundice 29.72 9.70 279 799258 58957 109730805
Hallucination, auditory 29.58 9.70 95 799442 26302 109763460
Hepatotoxicity 29.55 9.70 304 799233 63096 109726666
Rotator cuff repair 29.22 9.70 56 799481 2210 109787552
Mouth ulceration 29.21 9.70 500 799037 47638 109742124
Enterocolitis 29.15 9.70 58 799479 18891 109770871
Transaminases increased 29.11 9.70 305 799232 63085 109726677
Atrial tachycardia 29.05 9.70 15 799522 9163 109780599
Pemphigoid 28.89 9.70 62 799475 19645 109770117
Hyperammonaemia 28.85 9.70 34 799503 13698 109776064
Blood urea increased 28.81 9.70 256 799281 54701 109735061
Diabetes mellitus 28.80 9.70 525 799012 98856 109690906
Gastroenteritis viral 28.80 9.70 349 799188 30877 109758885
Pruritus genital 28.78 9.70 6 799531 6516 109783246
Diplopia 28.71 9.70 181 799356 41713 109748049
Multiple drug therapy 28.66 9.70 11 799526 8003 109781759
Cytomegalovirus chorioretinitis 28.63 9.70 8 799529 7120 109782642
Hyperlactacidaemia 28.61 9.70 12 799525 8274 109781488
Vasoplegia syndrome 28.60 9.70 3 799534 5436 109784326
Immune effector cell-associated neurotoxicity syndrome 28.56 9.70 39 799498 14743 109775019
Mite allergy 28.55 9.70 4 799533 5799 109783963
Pneumatosis intestinalis 28.43 9.70 13 799524 8516 109781246
Malignant mediastinal neoplasm 28.39 9.70 42 799495 1336 109788426
Drug tolerance 28.16 9.70 211 799326 16374 109773388
Febrile bone marrow aplasia 28.14 9.70 52 799485 17413 109772349
Myasthenia gravis 28.08 9.70 72 799465 21439 109768323
Bacterial infection 28.01 9.70 206 799331 45830 109743932
Hypoalbuminaemia 27.99 9.70 111 799426 28863 109760899
Synovial disorder 27.93 9.70 65 799472 2942 109786820
Pulseless electrical activity 27.80 9.70 49 799488 16708 109773054
Hyperlipidaemia 27.70 9.70 149 799388 35699 109754063
Toxic encephalopathy 27.56 9.70 42 799495 15172 109774590
Epistaxis 27.33 9.70 725 798812 129647 109660115
Liver function test increased 27.31 9.70 836 798701 87712 109702050
Skin toxicity 27.17 9.70 27 799510 11756 109778006
Sensory loss 27.11 9.70 73 799464 21384 109768378
Hypernatraemia 27.08 9.70 55 799482 17778 109771984
Lip swelling 27.01 9.70 235 799302 50432 109739330
Paranoia 26.87 9.70 78 799459 22296 109767466
Hepatitis cholestatic 26.82 9.70 54 799483 17512 109772250
Pyrexia 26.76 9.70 5916 793621 892349 108897413
Rheumatoid lung 26.66 9.70 80 799457 4224 109785538
Peripheral sensory neuropathy 26.58 9.70 50 799487 16630 109773132
Lung opacity 26.52 9.70 27 799510 11625 109778137
Paralysis 26.44 9.70 45 799492 15555 109774207
Device related infection 26.43 9.70 172 799365 39347 109750415
Panniculitis 26.32 9.70 198 799339 15384 109774378
Troponin increased 26.30 9.70 118 799419 29648 109760114
Hypocalcaemia 26.30 9.70 324 799213 65042 109724720
Affect lability 26.20 9.70 60 799477 18577 109771185
Bronchitis 26.08 9.70 1387 798150 155645 109634117
Neck pain 26.06 9.70 1114 798423 122016 109667746
Synovial fluid analysis 26.06 9.70 59 799478 2622 109787140
Eye pruritus 26.01 9.70 135 799402 32640 109757122
Premature delivery 25.95 9.70 337 799200 30295 109759467
Hyperpyrexia 25.82 9.70 13 799524 8056 109781706
Myopathy 25.81 9.70 93 799444 24867 109764895
Progressive multifocal leukoencephalopathy 25.80 9.70 93 799444 24863 109764899
Lymphopenia 25.78 9.70 177 799360 39993 109749769
Drug effective for unapproved indication 25.77 9.70 39 799498 14128 109775634
Ankle arthroplasty 25.76 9.70 57 799480 2494 109787268
Therapy non-responder 25.64 9.70 1387 798150 155920 109633842
Pulmonary haemorrhage 25.63 9.70 50 799487 16406 109773356
Hepatitis fulminant 25.63 9.70 15 799522 8545 109781217
Subarachnoid haemorrhage 25.50 9.70 119 799418 29583 109760179
Sleep terror 25.49 9.70 8 799529 6602 109783160
Chills 25.22 9.70 1123 798414 189457 109600305
Diabetes mellitus inadequate control 25.15 9.70 120 799417 29655 109760107
Dermatitis acneiform 25.03 9.70 33 799504 12662 109777100
Thrombosis 25.00 9.70 596 798941 108066 109681696
Product preparation error 25 9.70 25 799512 10854 109778908
International normalised ratio increased 24.95 9.70 459 799078 86313 109703449
Immune-mediated myositis 24.74 9.70 7 799530 6179 109783583
Right ventricular failure 24.71 9.70 100 799437 25854 109763908
Myocardial ischaemia 24.67 9.70 104 799433 26580 109763182
Bone disorder 24.66 9.70 248 799289 20944 109768818
Ventricular arrhythmia 24.56 9.70 22 799515 10065 109779697
Gangrene 24.30 9.70 51 799486 16290 109773472
Tenosynovitis stenosans 24.27 9.70 69 799468 3534 109786228
Polyuria 24.22 9.70 58 799479 17680 109772082
Pancytopenia 24.21 9.70 1794 797743 207819 109581943
Product administered to patient of inappropriate age 24.18 9.70 14 799523 8022 109781740
Hypogammaglobulinaemia 24.10 9.70 70 799467 20006 109769756
Circulatory collapse 24.00 9.70 197 799340 42796 109746966
Cleft lip and palate 23.94 9.70 28 799509 704 109789058
Alanine aminotransferase increased 23.88 9.70 1085 798452 182688 109607074
Pneumonia bacterial 23.88 9.70 103 799434 26158 109763604
Skin papilloma 23.81 9.70 106 799431 6790 109782972
Bladder cancer 23.46 9.70 72 799465 20220 109769542
Blindness 23.44 9.70 160 799377 36199 109753563
Bradykinesia 23.43 9.70 26 799511 10762 109779000
Atrioventricular block complete 23.40 9.70 71 799466 20011 109769751
Product dose omission issue 23.37 9.70 2005 797532 319777 109469985
Loose body in joint 23.32 9.70 39 799498 1381 109788381
Strongyloidiasis 23.25 9.70 4 799533 4982 109784780
Respiration abnormal 23.17 9.70 22 799515 9787 109779975
Hypercapnia 23.05 9.70 28 799509 11131 109778631
Virologic failure 23.04 9.70 4 799533 4948 109784814
Normal newborn 23.01 9.70 251 799286 21645 109768117
Blood pressure increased 22.95 9.70 2168 797369 256205 109533557
Presyncope 22.95 9.70 234 799303 48653 109741109
Pericardial effusion 22.87 9.70 284 799253 56933 109732829
Full blood count abnormal 22.86 9.70 277 799260 55775 109733987
Cross sensitivity reaction 22.83 9.70 6 799531 5561 109784201
Schizophrenia 22.79 9.70 81 799456 21745 109768017
Kidney transplant rejection 22.78 9.70 32 799505 11955 109777807
Joint injury 22.69 9.70 411 799126 39583 109750179
Dysphonia 22.67 9.70 399 799138 75530 109714232
Walking aid user 22.58 9.70 279 799258 24796 109764966
Product label confusion 22.48 9.70 257 799280 22420 109767342
Hydrops foetalis 22.48 9.70 28 799509 753 109789009
Product prescribing issue 22.43 9.70 36 799501 12736 109777026
Atrioventricular block 22.41 9.70 56 799481 16821 109772941
Affective disorder 22.39 9.70 29 799508 11212 109778550
Haematemesis 22.29 9.70 297 799240 58811 109730951
Amyloid arthropathy 22.26 9.70 42 799495 1638 109788124
Venoocclusive disease 22.25 9.70 9 799528 6341 109783421
Sputum discoloured 22.24 9.70 115 799422 27830 109761932
Acute myeloid leukaemia recurrent 22.13 9.70 5 799532 5134 109784628
Foot fracture 22.05 9.70 282 799255 25264 109764498
Nasal oedema 22.04 9.70 103 799434 6736 109783026
Nail operation 22.01 9.70 42 799495 1652 109788110
Dyspnoea exertional 21.99 9.70 578 798959 103482 109686280
Hyperprolactinaemia 21.95 9.70 10 799527 6565 109783197
Hypoxic-ischaemic encephalopathy 21.90 9.70 19 799518 8828 109780934
Gastric haemorrhage 21.77 9.70 52 799485 15863 109773899
Renal tubular necrosis 21.75 9.70 130 799407 30345 109759417
Pulmonary hypertension 21.73 9.70 275 799262 54945 109734817
Poor venous access 21.72 9.70 272 799265 24250 109765512
Transplant dysfunction 21.71 9.70 17 799520 8311 109781451
Type 1 diabetes mellitus 21.71 9.70 20 799517 9027 109780735
Bacterial sepsis 21.70 9.70 26 799511 10400 109779362
Adverse drug reaction 21.67 9.70 952 798585 104607 109685155
Postoperative wound infection 21.65 9.70 191 799346 15562 109774200
Immune-mediated enterocolitis 21.63 9.70 25 799512 10160 109779602
Pulmonary congestion 21.62 9.70 133 799404 30833 109758929
Immunosuppressant drug level increased 21.59 9.70 32 799505 11692 109778070
Hypertransaminasaemia 21.52 9.70 96 799441 24159 109765603
Acute graft versus host disease in intestine 21.44 9.70 7 799530 5632 109784130
Ultrasound antenatal screen 21.43 9.70 26 799511 680 109789082
Spondylitis 21.42 9.70 148 799389 11190 109778572
Renal injury 21.21 9.70 67 799470 18646 109771116
Human antichimeric antibody positive 21.18 9.70 42 799495 1700 109788062
Ketoacidosis 21.16 9.70 25 799512 10062 109779700
Ulcer haemorrhage 21.13 9.70 253 799284 22318 109767444
Mucocutaneous ulceration 21.06 9.70 27 799510 748 109789014
Product administration error 21.02 9.70 170 799367 37047 109752715
Fracture delayed union 20.91 9.70 48 799489 2153 109787609
Bradypnoea 20.90 9.70 19 799518 8630 109781132
COVID-19 pneumonia 20.82 9.70 170 799367 36973 109752789
Rales 20.72 9.70 100 799437 24639 109765123
Capillary leak syndrome 20.69 9.70 5 799532 4903 109784859
Acute lymphocytic leukaemia recurrent 20.60 9.70 8 799529 5779 109783983
Dysgeusia 20.50 9.70 369 799168 69616 109720146
Human herpesvirus 6 infection 20.47 9.70 11 799526 6570 109783192
Lipase increased 20.37 9.70 68 799469 18604 109771158
Sleep disorder due to a general medical condition 20.33 9.70 260 799277 51852 109737910
Hepatocellular carcinoma 20.19 9.70 25 799512 9855 109779907
Metastasis 20.17 9.70 18 799519 8249 109781513
Arterial occlusive disease 20.16 9.70 51 799486 15257 109774505
Vertigo 20.12 9.70 476 799061 86394 109703368
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.11 9.70 7 799530 5410 109784352
Pain in jaw 20.09 9.70 255 799282 50922 109738840
Blood lactate dehydrogenase increased 20.08 9.70 214 799323 44120 109745642
Joint noise 20.04 9.70 82 799455 5061 109784701
Salivary hypersecretion 20.01 9.70 62 799475 17359 109772403
Palmoplantar keratoderma 19.93 9.70 7 799530 5380 109784382
Foot operation 19.91 9.70 105 799432 7208 109782554
Acute pulmonary oedema 19.87 9.70 60 799477 16936 109772826
Ventricular extrasystoles 19.86 9.70 90 799447 22551 109767211
Fear of injection 19.69 9.70 121 799416 8790 109780972
Polydipsia 19.66 9.70 16 799521 7672 109782090
Amylase increased 19.53 9.70 38 799499 12481 109777281
Linear IgA disease 19.45 9.70 4 799533 4385 109785377
Incoherent 19.45 9.70 19 799518 8339 109781423
Accidental death 19.43 9.70 6 799531 5003 109784759
Breast cancer stage I 19.36 9.70 15 799522 7372 109782390
Lymphatic fistula 19.34 9.70 37 799500 1458 109788304
Anosmia 19.34 9.70 38 799499 12434 109777328
Heparin-induced thrombocytopenia 19.32 9.70 33 799504 11391 109778371
Epilepsy 19.31 9.70 898 798639 99311 109690451
Therapy interrupted 19.28 9.70 249 799288 49573 109740189
Total lung capacity decreased 19.22 9.70 14 799523 7100 109782662
Ingrown hair 19.17 9.70 26 799511 762 109789000
Femoral hernia incarcerated 19.10 9.70 37 799500 1472 109788290
Trisomy 18 19.07 9.70 23 799514 598 109789164
Neurological symptom 19.05 9.70 54 799483 15554 109774208
Congestive cardiomyopathy 19.02 9.70 47 799490 14172 109775590
Hypertriglyceridaemia 18.91 9.70 57 799480 16097 109773665
Psychiatric decompensation 18.89 9.70 9 799528 5756 109784006
Therapeutic response decreased 18.87 9.70 866 798671 95633 109694129
Ileus paralytic 18.86 9.70 35 799502 11702 109778060
Intervertebral disc degeneration 18.86 9.70 207 799330 17878 109771884
Oesophageal carcinoma 18.84 9.70 34 799503 11490 109778272
Laryngeal oedema 18.82 9.70 26 799511 9781 109779981
Exposure via ingestion 18.77 9.70 6 799531 4894 109784868
Analgesic drug level increased 18.77 9.70 3 799534 3943 109785819
Skin cancer 18.75 9.70 204 799333 17580 109772182
Prostatic specific antigen increased 18.65 9.70 39 799498 12472 109777290
Systemic candida 18.59 9.70 27 799510 9947 109779815
Depressive symptom 18.59 9.70 20 799517 8394 109781368
Foetal exposure during pregnancy 18.58 9.70 105 799432 7400 109782362
Left ventricular dysfunction 18.51 9.70 97 799440 23396 109766366
Oropharyngeal pain 18.47 9.70 1174 798363 134102 109655660
Complications of transplanted kidney 18.40 9.70 16 799521 7426 109782336
Antibody test positive 18.40 9.70 57 799480 3063 109786699
Anhedonia 18.37 9.70 54 799483 15374 109774388
Systemic inflammatory response syndrome 18.33 9.70 42 799495 13001 109776761
Hyperphosphataemia 18.32 9.70 59 799478 16322 109773440
Treatment noncompliance 18.30 9.70 395 799142 72595 109717167
Body height below normal 18.22 9.70 44 799493 2040 109787722
Intracranial pressure increased 18.22 9.70 30 799507 10505 109779257
Polyhydramnios 18.19 9.70 42 799495 1891 109787871
Neuritis 18.18 9.70 16 799521 7383 109782379
Swelling face 18.16 9.70 518 799019 91803 109697959
Colitis microscopic 18.13 9.70 44 799493 13350 109776412
Wound infection pseudomonas 18.05 9.70 48 799489 2363 109787399
Short stature 18.05 9.70 30 799507 1057 109788705
Vascular stent thrombosis 18.01 9.70 4 799533 4157 109785605
Disturbance in social behaviour 18.00 9.70 7 799530 5051 109784711
Sudden death 17.98 9.70 103 799434 24292 109765470
Temperature intolerance 17.97 9.70 47 799490 13903 109775859
Long QT syndrome 17.97 9.70 15 799522 7103 109782659
Eosinophilic granulomatosis with polyangiitis 17.95 9.70 31 799506 10655 109779107
Malignant melanoma 17.92 9.70 194 799343 16697 109773065
Varicella zoster virus infection 17.91 9.70 12 799525 6356 109783406
Hypertensive crisis 17.91 9.70 103 799434 24269 109765493
Methaemoglobinaemia 17.90 9.70 24 799513 9144 109780618
Breast feeding 17.83 9.70 24 799513 698 109789064
Skin burning sensation 17.83 9.70 89 799448 21736 109768026
Mucosal inflammation 17.77 9.70 544 798993 95597 109694165
Deep vein thrombosis 17.75 9.70 828 798709 139059 109650703
Post procedural infection 17.74 9.70 165 799372 13644 109776118
Pulmonary function test abnormal 17.66 9.70 7 799530 4993 109784769
Hydrocephalus 17.52 9.70 30 799507 10345 109779417
Cholangitis 17.47 9.70 60 799477 16275 109773487
Hypotonia 17.41 9.70 57 799480 15688 109774074
Pseudomonal sepsis 17.34 9.70 24 799513 9022 109780740
Herpes zoster 17.34 9.70 954 798583 107425 109682337
Neutrophilia 17.32 9.70 30 799507 10299 109779463
Hypophagia 17.19 9.70 272 799265 52354 109737408
Cryptococcosis 17.17 9.70 6 799531 4625 109785137
Therapeutic product effect incomplete 17.15 9.70 1859 797678 221946 109567816
Injection site warmth 17.14 9.70 197 799340 17208 109772554
Rhinitis allergic 17.10 9.70 69 799468 17853 109771909
Hypervolaemia 17.06 9.70 253 799284 49207 109740555
Eczema 17.05 9.70 395 799142 71898 109717864
Porphyria acute 16.93 9.70 209 799328 18571 109771191
Metastases to lymph nodes 16.91 9.70 54 799483 14978 109774784
Brain injury 16.91 9.70 46 799491 13430 109776332
Asthenia 16.89 9.70 4578 794959 684421 109105341
Hyperthyroidism 16.83 9.70 133 799404 29128 109760634
Jaundice cholestatic 16.77 9.70 52 799485 14556 109775206
Haematuria 16.77 9.70 464 799073 82541 109707221
Placental disorder 16.71 9.70 28 799509 993 109788769
Creatinine renal clearance increased 16.71 9.70 3 799534 3622 109786140
Brain natriuretic peptide increased 16.66 9.70 35 799502 11174 109778588
Personality change 16.65 9.70 34 799503 10968 109778794
Tetany 16.57 9.70 3 799534 3601 109786161
Eosinophil count increased 16.56 9.70 87 799450 20971 109768791
Abdominal pain upper 16.55 9.70 2818 796719 346293 109443469
Myoglobin blood increased 16.54 9.70 5 799532 4227 109785535
Post-traumatic stress disorder 16.53 9.70 14 799523 6582 109783180
Nervous system disorder 16.52 9.70 148 799389 31573 109758189
Antineutrophil cytoplasmic antibody positive 16.51 9.70 8 799529 5068 109784694
Mood altered 16.43 9.70 89 799448 21286 109768476
Endodontic procedure 16.41 9.70 55 799482 3081 109786681
Small for dates baby 16.34 9.70 22 799515 640 109789122
Concomitant disease aggravated 16.25 9.70 62 799475 16302 109773460
Pulmonary pain 16.22 9.70 89 799448 6204 109783558
Cardiac septal defect 16.19 9.70 27 799510 954 109788808
Erectile dysfunction 16.13 9.70 74 799463 18482 109771280
Vascular device infection 16.11 9.70 63 799474 16449 109773313
Injection site bruising 16.08 9.70 485 799052 50778 109738984
Confusional state 16.07 9.70 3723 795814 464957 109324805
Maternal exposure during breast feeding 16.06 9.70 67 799470 4171 109785591
Blood glucose decreased 16.06 9.70 136 799401 29352 109760410
Osteonecrosis 16.05 9.70 161 799376 33580 109756182
Hepatitis B 16.04 9.70 28 799509 9584 109780178
Gait disturbance 16.00 9.70 2270 797267 275938 109513824
Incorrect dose administered 15.99 9.70 600 798937 103041 109686721
Hepatitis C 15.71 9.70 43 799494 12530 109777232
Syringe issue 15.67 9.70 28 799509 9497 109780265
Extra dose administered 15.64 9.70 41 799496 12118 109777644
Infection reactivation 15.63 9.70 5 799532 4076 109785686
Diaphragmatic disorder 15.62 9.70 39 799498 1847 109787915
Drug screen positive 15.59 9.70 14 799523 6396 109783366
Benign ovarian tumour 15.53 9.70 18 799519 448 109789314
Type I hypersensitivity 15.50 9.70 14 799523 6379 109783383
Compartment syndrome 15.49 9.70 12 799525 5898 109783864
Electrolyte imbalance 15.48 9.70 182 799355 36846 109752916
Complication of device removal 15.46 9.70 7 799530 4613 109785149
Lower respiratory tract congestion 15.28 9.70 72 799465 4724 109785038
Plasma cell myeloma recurrent 15.27 9.70 17 799520 7025 109782737
Foetal distress syndrome 15.21 9.70 21 799516 626 109789136
Pharyngeal swelling 15.15 9.70 41 799496 11991 109777771
Anticholinergic syndrome 15.10 9.70 6 799531 4274 109785488
Extradural haematoma 15.08 9.70 3 799534 3366 109786396
Stillbirth 15.07 9.70 66 799471 4198 109785564
Insurance issue 15.05 9.70 34 799503 10578 109779184
Device loosening 15.01 9.70 24 799513 818 109788944
Enterococcal infection 15.00 9.70 86 799451 20280 109769482
Epstein-Barr virus associated lymphoproliferative disorder 14.98 9.70 8 799529 4794 109784968
Mental impairment 14.90 9.70 99 799438 22540 109767222
Radiation inflammation 14.89 9.70 27 799510 1021 109788741
Erythema 14.88 9.70 1862 797675 289585 109500177
Head injury 14.85 9.70 220 799317 42797 109746965
Hepatic cancer 14.82 9.70 37 799500 11119 109778643
Autonomic nervous system imbalance 14.82 9.70 12 799525 5768 109783994
Device occlusion 14.78 9.70 58 799479 15127 109774635
Anal fissure 14.73 9.70 122 799415 9759 109780003
Hepatic necrosis 14.73 9.70 31 799506 9891 109779871
Nervousness 14.69 9.70 183 799354 36668 109753094
Visual acuity reduced 14.69 9.70 155 799382 32018 109757744
Activated partial thromboplastin time prolonged 14.63 9.70 98 799439 22270 109767492
Catarrh 14.61 9.70 97 799440 7238 109782524
Bone density increased 14.60 9.70 26 799511 969 109788793
Clostridium test positive 14.57 9.70 36 799501 10857 109778905
Colitis 14.56 9.70 598 798939 101725 109688037
Atrial flutter 14.55 9.70 109 799428 24153 109765609
Multiple allergies 14.55 9.70 43 799494 12220 109777542
Swollen joint count 14.53 9.70 110 799427 8564 109781198
Neoplasm recurrence 14.52 9.70 10 799527 5222 109784540
Extravascular haemolysis 14.49 9.70 17 799520 429 109789333
Nightmare 14.39 9.70 196 799341 38667 109751095
Sickle cell anaemia 14.38 9.70 23 799514 784 109788978
Haemorrhage in pregnancy 14.35 9.70 35 799502 1633 109788129
Infusion site reaction 14.34 9.70 193 799344 17489 109772273
Osteopenia 14.32 9.70 233 799304 21976 109767786
Placental insufficiency 14.31 9.70 30 799507 1264 109788498
Mitochondrial toxicity 14.29 9.70 3 799534 3242 109786520
Nail injury 14.26 9.70 23 799514 790 109788972
Plasma cell myeloma 14.26 9.70 346 799191 62590 109727172
Staphylococcal bacteraemia 14.24 9.70 67 799470 16621 109773141
Laryngospasm 14.23 9.70 8 799529 4660 109785102
Swollen tongue 14.18 9.70 330 799207 60032 109729730
Staphylococcal infection 14.12 9.70 391 799146 69553 109720209
Hyperventilation 14.10 9.70 27 799510 8920 109780842
Wrong product administered 14.06 9.70 37 799500 10923 109778839
Breast cancer stage II 14.04 9.70 277 799260 27098 109762664
Accidental overdose 14.04 9.70 277 799260 51557 109738205
Ear pain 13.96 9.70 493 799044 52733 109737029
Cough 13.92 9.70 3038 796499 458603 109331159
Ligament rupture 13.92 9.70 62 799475 3973 109785789
Hallucinations, mixed 13.90 9.70 26 799511 8667 109781095
Metabolic disorder 13.86 9.70 35 799502 10475 109779287
Renal cancer 13.86 9.70 48 799489 12986 109776776
Sneezing 13.84 9.70 156 799381 31828 109757934
Retinal haemorrhage 13.84 9.70 30 799507 9471 109780291
Corneal oedema 13.84 9.70 3 799534 3170 109786592
Central nervous system mass 13.82 9.70 23 799514 811 109788951
Eyelid oedema 13.79 9.70 60 799477 15202 109774560
Cyst 13.77 9.70 181 799356 16315 109773447
Lip oedema 13.75 9.70 21 799516 7579 109782183
Immune-mediated hepatitis 13.69 9.70 17 799520 6694 109783068
Troponin T increased 13.69 9.70 7 799530 4299 109785463
Wall motion score index abnormal 13.68 9.70 23 799514 818 109788944
Cerebral toxoplasmosis 13.64 9.70 3 799534 3139 109786623
Vasculitis 13.62 9.70 180 799357 35693 109754069
Anger 13.61 9.70 81 799456 18926 109770836
Cushingoid 13.60 9.70 137 799400 11575 109778187
Aspiration 13.58 9.70 148 799389 30385 109759377
Hypoglycaemic coma 13.56 9.70 12 799525 5521 109784241
Spinal cord compression 13.54 9.70 21 799516 7531 109782231
Immune thrombocytopenia 13.52 9.70 101 799436 22393 109767369
Lacrimal disorder 13.52 9.70 18 799519 518 109789244
Cardiac dysfunction 13.52 9.70 15 799522 6208 109783554
Lymph gland infection 13.50 9.70 20 799517 637 109789125
Bone density abnormal 13.48 9.70 60 799477 3843 109785919
Mitral valve incompetence 13.48 9.70 165 799372 33164 109756598
Blood folate increased 13.45 9.70 19 799518 579 109789183
Bronchial secretion retention 13.42 9.70 10 799527 5014 109784748
Respiratory tract infection 13.42 9.70 640 798897 70977 109718785
Hypertension 13.41 9.70 4006 795531 506078 109283684
Delayed graft function 13.41 9.70 7 799530 4250 109785512
Bone marrow failure 13.39 9.70 317 799220 57531 109732231
Pancreatic steatosis 13.37 9.70 36 799501 1786 109787976
Steroid diabetes 13.35 9.70 11 799526 5243 109784519
Nephrotic syndrome 13.35 9.70 53 799484 13778 109775984
Reversible cerebral vasoconstriction syndrome 13.35 9.70 9 799528 4752 109785010
Granulocyte count decreased 13.33 9.70 6 799531 3968 109785794
Pneumonia fungal 13.33 9.70 58 799479 14696 109775066
Induced labour 13.32 9.70 24 799513 903 109788859
Blood potassium increased 13.30 9.70 165 799372 33084 109756678
Haematocrit decreased 13.28 9.70 595 798942 65522 109724240
Cytomegalovirus colitis 13.27 9.70 19 799518 7042 109782720
Cervical incompetence 13.23 9.70 18 799519 529 109789233
Abortion incomplete 13.20 9.70 3 799534 3069 109786693
Kounis syndrome 13.18 9.70 14 799523 5911 109783851
Upper gastrointestinal haemorrhage 13.18 9.70 269 799268 49827 109739935
Spinal osteoarthritis 13.11 9.70 212 799325 19971 109769791
Obsessive-compulsive disorder 13.11 9.70 20 799517 7221 109782541
Injection site swelling 13.06 9.70 559 798978 61231 109728531
Urinary incontinence 13.05 9.70 260 799277 48327 109741435
Cyst rupture 13.02 9.70 23 799514 852 109788910
Ataxia 12.97 9.70 147 799390 29961 109759801
Heart rate irregular 12.92 9.70 332 799205 33942 109755820
Fungaemia 12.86 9.70 15 799522 6071 109783691
Taste disorder 12.82 9.70 587 798950 64800 109724962
Iritis 12.81 9.70 67 799470 4585 109785177
Blood loss anaemia 12.80 9.70 77 799460 17948 109771814
Complication of device insertion 12.80 9.70 28 799509 8810 109780952
Gastric cancer 12.77 9.70 39 799498 10969 109778793
Broncholithiasis 12.74 9.70 13 799524 279 109789483
Nystagmus 12.74 9.70 42 799495 11535 109778227
Impaired gastric emptying 12.73 9.70 51 799486 13224 109776538
Injection site rash 12.70 9.70 239 799298 23180 109766582
Chronic obstructive pulmonary disease 12.69 9.70 652 798885 108506 109681256
Epstein-Barr viraemia 12.66 9.70 5 799532 3574 109786188
Dizziness 12.63 9.70 4696 794841 693497 109096265
Uveitis 12.63 9.70 224 799313 21486 109768276
Enterobacter infection 12.63 9.70 14 799523 5797 109783965
Leukoencephalopathy 12.61 9.70 30 799507 9165 109780597
Panic attack 12.58 9.70 141 799396 28799 109760963
Product dose omission in error 12.55 9.70 109 799428 23403 109766359
Viraemia 12.55 9.70 7 799530 4095 109785667
Vein disorder 12.54 9.70 83 799454 6187 109783575
Breast cancer female 12.53 9.70 47 799490 12421 109777341
Device breakage 12.52 9.70 54 799483 13715 109776047
Liver abscess 12.51 9.70 23 799514 7716 109782046
Wrong patient received product 12.50 9.70 18 799519 6656 109783106
Hand fracture 12.50 9.70 101 799436 8021 109781741
Embolism 12.42 9.70 68 799469 16221 109773541
Dactylitis 12.42 9.70 61 799476 4072 109785690
SARS-CoV-2 test negative 12.39 9.70 39 799498 2114 109787648
Burns second degree 12.36 9.70 97 799440 7636 109782126
Transient aphasia 12.36 9.70 20 799517 689 109789073
Product monitoring error 12.34 9.70 29 799508 8898 109780864
Coeliac disease 12.34 9.70 404 799133 42783 109746979
Injection site extravasation 12.31 9.70 120 799417 10049 109779713
Fanconi syndrome 12.31 9.70 5 799532 3514 109786248
Defaecation disorder 12.30 9.70 22 799515 823 109788939
Increased appetite 12.28 9.70 61 799476 14916 109774846
Joint lock 12.28 9.70 55 799482 3533 109786229
Human anti-human antibody test 12.26 9.70 15 799522 396 109789366
Sleep disorder therapy 12.25 9.70 22 799515 7449 109782313
Pneumomediastinum 12.24 9.70 11 799526 5025 109784737
Arteriospasm coronary 12.23 9.70 30 799507 9070 109780692
Oligoarthritis 12.23 9.70 21 799516 760 109789002
Genital haemorrhage 12.22 9.70 21 799516 7231 109782531
Hypoventilation 12.20 9.70 25 799512 8056 109781706
Vascular purpura 12.18 9.70 6 799531 3765 109785997
Lymphoedema 12.13 9.70 61 799476 14868 109774894
Tumour haemorrhage 12.11 9.70 12 799525 5233 109784529
Accidental exposure to product by child 12.10 9.70 4 799533 3194 109786568
Renal tubular disorder 12.07 9.70 22 799515 7407 109782355
Infusion site pain 12.07 9.70 75 799462 17344 109772418
Tender joint count increased 12.05 9.70 15 799522 403 109789359
Behaviour disorder 12.05 9.70 33 799504 9614 109780148
Parvovirus B19 infection 12.02 9.70 3 799534 2878 109786884
Immunisation 12.01 9.70 4 799533 3179 109786583
Pain of skin 12.01 9.70 90 799447 19939 109769823
Areflexia 11.96 9.70 19 799518 6750 109783012
Bronchopulmonary aspergillosis allergic 11.95 9.70 27 799510 8399 109781363
Muscle spasticity 11.95 9.70 185 799352 35730 109754032
Tension headache 11.94 9.70 33 799504 9585 109780177
Terminal state 11.94 9.70 14 799523 5653 109784109
Dermatitis exfoliative 11.92 9.70 42 799495 11305 109778457
Poor quality device used 11.91 9.70 3 799534 2860 109786902
Tubulointerstitial nephritis 11.87 9.70 300 799237 53984 109735778
Threatened labour 11.85 9.70 19 799518 649 109789113
C-reactive protein decreased 11.83 9.70 47 799490 2862 109786900
Cold sweat 11.82 9.70 102 799435 21929 109767833
Airway remodelling 11.80 9.70 23 799514 919 109788843
Drug abuser 11.79 9.70 13 799524 5396 109784366
Hypovolaemia 11.79 9.70 100 799437 21574 109768188
Cardiac tamponade 11.78 9.70 42 799495 11265 109778497
Cogwheel rigidity 11.77 9.70 6 799531 3692 109786070
Purpura 11.75 9.70 116 799421 24272 109765490
Schizoaffective disorder 11.73 9.70 4 799533 3132 109786630
Drooling 11.73 9.70 21 799516 7118 109782644
Mesothelioma 11.73 9.70 14 799523 360 109789402
Alcohol abuse 11.71 9.70 11 799526 4918 109784844
Rash morbilliform 11.67 9.70 25 799512 7926 109781836
Throat tightness 11.65 9.70 171 799366 33318 109756444
Bone fissure 11.64 9.70 18 799519 596 109789166
Lower gastrointestinal haemorrhage 11.59 9.70 82 799455 18404 109771358
Pancreatitis 11.59 9.70 555 798982 92978 109696784
Dysuria 11.58 9.70 339 799198 59892 109729870
Choking 11.57 9.70 63 799474 15047 109774715
Liver transplant rejection 11.54 9.70 7 799530 3911 109785851
Erythema of eyelid 11.53 9.70 7 799530 3908 109785854
Musculoskeletal disorder 11.51 9.70 229 799308 22435 109767327
Clonus 11.51 9.70 29 799508 8687 109781075
Crying 11.49 9.70 124 799413 25504 109764258
Carcinoid tumour of the small bowel 11.44 9.70 15 799522 425 109789337
Thirst 11.43 9.70 101 799436 21606 109768156
Oesophageal fibrosis 11.41 9.70 10 799527 176 109789586
Blood uric acid increased 11.41 9.70 100 799437 21429 109768333
Hypopituitarism 11.40 9.70 9 799528 4381 109785381
Joint warmth 11.33 9.70 37 799500 2045 109787717
Hypochloraemia 11.32 9.70 6 799531 3612 109786150
Inadequate analgesia 11.29 9.70 12 799525 5065 109784697
Labyrinthitis 11.29 9.70 48 799489 3014 109786748
Hypomania 11.26 9.70 37 799500 10173 109779589
Anaesthetic complication 11.26 9.70 6 799531 3600 109786162
Pseudomembranous colitis 11.24 9.70 18 799519 6373 109783389
Unevaluable event 11.22 9.70 334 799203 58893 109730869
Ulcer 11.22 9.70 399 799138 42717 109747045
Pharyngitis streptococcal 11.22 9.70 146 799391 13131 109776631
Tumour marker increased 11.21 9.70 12 799525 5048 109784714
Oxygen saturation decreased 11.21 9.70 1298 798239 155684 109634078
Lung transplant 11.20 9.70 13 799524 5273 109784489
Haemorrhagic transformation stroke 11.15 9.70 4 799533 3033 109786729
Epstein-Barr virus infection reactivation 11.08 9.70 8 799529 4076 109785686
Hypertonia 11.08 9.70 28 799509 8378 109781384
Oculogyric crisis 11.08 9.70 7 799530 3825 109785937
Brain abscess 11.06 9.70 20 799517 6754 109783008
Disorganised speech 11.06 9.70 5 799532 3298 109786464
Hypovolaemic shock 11.05 9.70 61 799476 14522 109775240
Arteriosclerosis 11.04 9.70 120 799417 24647 109765115
Neutrophil count increased 11.02 9.70 180 799357 34472 109755290
Feeding disorder 10.98 9.70 100 799437 21262 109768500
Apnoea 10.92 9.70 56 799481 13583 109776179
Facial paralysis 10.92 9.70 117 799420 24097 109765665
Apraxia 10.89 9.70 6 799531 3534 109786228
Osteoporotic fracture 10.88 9.70 71 799466 5266 109784496
Gastric ulcer haemorrhage 10.85 9.70 37 799500 10057 109779705
Pancreatic carcinoma 10.85 9.70 63 799474 14809 109774953
Fibroadenoma of breast 10.83 9.70 19 799518 700 109789062
Skin necrosis 10.81 9.70 217 799320 21295 109768467
Myofascial pain syndrome 10.81 9.70 42 799495 2531 109787231
Persecutory delusion 10.80 9.70 18 799519 6273 109783489
Clear cell renal cell carcinoma 10.78 9.70 44 799493 2712 109787050
CD4 lymphocytes decreased 10.77 9.70 4 799533 2970 109786792
Hospitalisation 10.76 9.70 885 798652 141608 109648154
Hereditary angioedema 10.75 9.70 22 799515 7092 109782670
Abortion threatened 10.75 9.70 15 799522 452 109789310
Angina unstable 10.75 9.70 72 799465 16360 109773402
Pneumonitis 10.73 9.70 448 799089 76083 109713679
Pupillary reflex impaired 10.72 9.70 8 799529 4007 109785755
Productive cough 10.72 9.70 697 798840 113608 109676154
Lymph node calcification 10.70 9.70 15 799522 454 109789308
Skin graft failure 10.67 9.70 11 799526 239 109789523
Staphylococcal sepsis 10.67 9.70 78 799459 17376 109772386
Cardiopulmonary failure 10.67 9.70 26 799511 7877 109781885
Lip blister 10.66 9.70 50 799487 3275 109786487
Tonic clonic movements 10.65 9.70 4 799533 2948 109786814
Autoimmune hepatitis 10.64 9.70 63 799474 14741 109775021
Analgesic therapy 10.61 9.70 23 799514 7261 109782501
Quadriparesis 10.61 9.70 11 799526 4696 109785066
Bradyarrhythmia 10.60 9.70 12 799525 4922 109784840
Tooth disorder 10.59 9.70 284 799253 29225 109760537
Brain herniation 10.57 9.70 31 799506 8832 109780930
Exercise tolerance decreased 10.56 9.70 48 799489 12019 109777743
Pallor 10.56 9.70 319 799218 56148 109733614
Medication error 10.56 9.70 892 798645 104474 109685288
Prerenal failure 10.53 9.70 10 799527 4449 109785313
Middle insomnia 10.53 9.70 96 799441 20406 109769356
Subileus 10.52 9.70 19 799518 6418 109783344
Blood phosphorus decreased 10.52 9.70 25 799512 7640 109782122
Catatonia 10.47 9.70 44 799493 11256 109778506
Breast abscess 10.45 9.70 32 799505 1709 109788053
Secondary adrenocortical insufficiency 10.41 9.70 10 799527 4424 109785338
Cholecystitis acute 10.40 9.70 69 799468 15713 109774049
Twin pregnancy 10.35 9.70 22 799515 936 109788826
Alcohol interaction 10.33 9.70 7 799530 3687 109786075
Haemorrhage subcutaneous 10.32 9.70 15 799522 5524 109784238
Trismus 10.31 9.70 20 799517 6576 109783186
Arteriosclerosis coronary artery 10.29 9.70 124 799413 24994 109764768
Lip and/or oral cavity cancer 10.27 9.70 25 799512 1165 109788597
Rhinovirus infection 10.26 9.70 47 799490 11742 109778020
Peritoneal dialysis complication 10.24 9.70 41 799496 2505 109787257
Aphthous ulcer 10.22 9.70 212 799325 20924 109768838
Tuberculin test positive 10.22 9.70 53 799484 3615 109786147
Brain death 10.21 9.70 20 799517 6553 109783209
Atrioventricular block second degree 10.21 9.70 28 799509 8153 109781609
Cancer pain 10.18 9.70 21 799516 6751 109783011
Drug specific antibody 10.17 9.70 44 799493 2784 109786978
Hemianopia 10.15 9.70 4 799533 2864 109786898
Swollen joint count decreased 10.15 9.70 13 799524 360 109789402
Device issue 10.14 9.70 182 799355 34353 109755409
Facial pain 10.14 9.70 67 799470 15272 109774490
Post procedural haemorrhage 10.13 9.70 68 799469 15444 109774318
Vacuum extractor delivery 10.13 9.70 8 799529 121 109789641
Sleep apnoea syndrome 10.11 9.70 219 799318 40228 109749534
Hyporesponsive to stimuli 10.11 9.70 4 799533 2856 109786906
Disinhibition 10.10 9.70 5 799532 3129 109786633
Vertebral osteophyte 10.10 9.70 16 799521 541 109789221
Knee operation 10.10 9.70 86 799451 6936 109782826
Loss of libido 10.10 9.70 5 799532 3128 109786634
Hyperreflexia 10.04 9.70 35 799502 9450 109780312
Hypokinesia 10.03 9.70 105 799432 21721 109768041
Hepatitis E antibody positive 10.01 9.70 11 799526 258 109789504
Impaired work ability 9.99 9.70 256 799281 26163 109763599
Squamous cell carcinoma of lung 9.98 9.70 43 799494 2716 109787046
Foetal hypokinesia 9.95 9.70 14 799523 425 109789337
Malnutrition 9.95 9.70 138 799399 27141 109762621
Back pain 9.94 9.70 2455 797082 368541 109421221
Abortion missed 9.93 9.70 29 799508 1508 109788254
Dermatitis bullous 9.93 9.70 80 799457 17449 109772313
Palmoplantar pustulosis 9.92 9.70 22 799515 964 109788798
Multiple injuries 9.91 9.70 7 799530 3607 109786155
Respiratory tract congestion 9.91 9.70 160 799377 30697 109759065
Anal inflammation 9.89 9.70 40 799497 2456 109787306
Joint ankylosis 9.88 9.70 40 799497 2457 109787305
Product administration interrupted 9.84 9.70 45 799492 11247 109778515
Drug therapy 9.83 9.70 24 799513 7267 109782495
Bone lesion 9.82 9.70 23 799514 7064 109782698
Hepatic cytolysis 9.81 9.70 313 799224 54740 109735022
Meningitis cryptococcal 9.78 9.70 12 799525 4750 109785012
Transfusion-related circulatory overload 9.78 9.70 21 799516 900 109788862
Radiation pneumonitis 9.78 9.70 11 799526 4525 109785237
Functional gastrointestinal disorder 9.75 9.70 18 799519 6031 109783731
Nasal obstruction 9.75 9.70 49 799488 3301 109786461
Coronary artery bypass 9.72 9.70 18 799519 6024 109783738

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Tinea pedis indication 6020002 DOID:12403
Wound indication 13924000
Burn injury indication 48333001
Candidiasis of skin indication 49883006
Pityriasis versicolor indication 56454009 DOID:9060
Hemorrhoids indication 70153002 DOID:9746
Rectal pain indication 77880009
Tinea corporis indication 84849002
Pruritus ani indication 90446007
Diaper rash indication 91487003
Eruption of skin indication 271807003 DOID:0050486
Skin irritation indication 367466007
Tinea cruris indication 399029005
Arthropod bite wound indication 409985002
Itching of skin indication 418363000
Minor Bacterial Skin Infections indication
Paronychia off-label use 71906005 DOID:13117
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Anxiety contraindication 48694002
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Hb SS disease contraindication 127040003 DOID:10923
Benign prostatic hyperplasia contraindication 266569009
Hemochromatosis contraindication 399187006 DOID:2352
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Nervousness contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.25%;81.35%;15% VUSION MYLAN N021026 Feb. 16, 2006 RX OINTMENT TOPICAL 8147852 March 30, 2028 USE FOR TREATMENT OF DIAPER DERMATITIS COMPLICATED BY CANDIDIASIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
SOI2LOH54Z UNII
4019034 VUID
N0000147305 NUI
D01170 KEGG_DRUG
4017643 VANDF
4019034 VANDF
4019036 VANDF
C0043491 UMLSCUI
CHEBI:36560 CHEBI
CHEMBL3988900 ChEMBL_ID
3007857 PUBCHEM_CID
DB09321 DRUGBANK_ID
D015034 MESH_DESCRIPTOR_UI
11423 RXNORM
5049 MMSL
5709 MMSL
001922 NDDF
398971002 SNOMEDCT_US
42841002 SNOMEDCT_US
SOI2LOH54Z INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 80 mg TOPICAL OTC Monograph Drug 13 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 80 mg TOPICAL OTC Monograph Drug 13 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 60 mg TOPICAL OTC Monograph Drug 13 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 60 mg TOPICAL OTC Monograph Drug 13 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 120 mg TOPICAL OTC Monograph Drug 13 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
SOLBAR SUNSCREEN 40 ZINC HUMAN OTC DRUG LABEL 3 0096-0691 CREAM 75 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 40 SHIELD HUMAN OTC DRUG LABEL 2 0096-0692 CREAM 75 mg TOPICAL OTC Monograph Drug 10 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0323 CREAM 40 g TOPICAL OTC Monograph Drug 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0323 CREAM 40 g TOPICAL OTC Monograph Drug 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0324 OINTMENT 16 g TOPICAL OTC Monograph Drug 13 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0333 CREAM 16 g TOPICAL OTC Monograph Drug 13 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0333 CREAM 16 g TOPICAL OTC Monograph Drug 13 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0334 CREAM 16 g TOPICAL OTC Monograph Drug 13 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0334 CREAM 16 g TOPICAL OTC Monograph Drug 13 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0557 CREAM 16 g TOPICAL export only 11 sections
Selan Plus Zinc Oxide HUMAN OTC DRUG LABEL 2 0159-2200 CREAM 2 g TOPICAL OTC Monograph Drug 11 sections
Selan Plus Zinc Oxide HUMAN OTC DRUG LABEL 2 0159-2200 CREAM 2 g TOPICAL OTC Monograph Drug 11 sections
CALENDULA DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2189 CREAM 12 g TOPICAL OTC monograph final 8 sections
WHITE MALLOW DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2207 CREAM 14 g TOPICAL OTC monograph final 8 sections
DR SMITHS DIAPER HUMAN OTC DRUG LABEL 1 0178-0330 OINTMENT 100 mg TOPICAL OTC Monograph Drug 11 sections
Dr. Smiths Rash and Skin HUMAN OTC DRUG LABEL 1 0178-0370 OINTMENT 10 g TOPICAL OTC monograph not final 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 25 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 25 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 25 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 25 mg ORAL Unapproved drug other 11 sections