zinc oxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4240 1314-13-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zinc oxide
A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.
  • Molecular weight: 81.38
  • Formula: OZn
  • CLOGP:
  • LIPINSKI: None
  • HAC: 1
  • HDO: 0
  • TPSA: 17.07
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 16, 2006 FDA DELCOR ASSET

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1156.04 9.69 3672 283591 236543 46162256
Pemphigus 947.65 9.69 1277 285986 43997 46354802
Systemic lupus erythematosus 817.83 9.69 1451 285812 63729 46335070
Completed suicide 666.04 9.69 64 287199 145856 46252943
Glossodynia 630.31 9.69 1044 286219 43329 46355470
Hand deformity 467.69 9.69 796 286467 33778 46365021
Maternal exposure during pregnancy 459.35 9.69 1532 285731 101017 46297782
Arthropathy 397.73 9.69 1286 285977 83414 46315385
Toxicity to various agents 387.71 9.69 439 286824 211327 46187472
Alopecia 384.53 9.69 1994 285269 160420 46238379
Joint swelling 355.18 9.69 1983 285280 164090 46234709
Abdominal discomfort 350.25 9.69 1845 285418 149320 46249479
Infusion related reaction 344.22 9.69 1383 285880 99825 46298974
Pain 334.56 9.69 4434 282829 472514 45926285
Death 325.89 9.69 1022 286241 334526 46064273
Arthralgia 315.54 9.69 3528 283735 361075 46037724
Wound 299.73 9.69 751 286512 42051 46356748
Drug abuse 296.70 9.69 25 287238 63383 46335416
Exposure during pregnancy 286.64 9.69 1372 285891 106840 46291959
Synovitis 271.09 9.69 910 286353 60165 46338634
Intentional overdose 256.55 9.69 45 287218 64899 46333900
Contraindicated product administered 240.13 9.69 1052 286211 78895 46319904
Anti-cyclic citrullinated peptide antibody positive 226.82 9.69 416 286847 18729 46380070
Drug interaction 207.25 9.69 604 286659 202490 46196309
Pericarditis 203.53 9.69 453 286810 23474 46375325
Swelling 197.14 9.69 1377 285886 123134 46275665
Rheumatoid factor positive 195.41 9.69 406 286857 20055 46378744
Nasopharyngitis 188.07 9.69 1603 285660 152395 46246404
Overdose 179.30 9.69 218 287045 101761 46297038
C-reactive protein abnormal 179.01 9.69 401 286862 20869 46377930
Hip arthroplasty 173.68 9.69 360 286903 17752 46381047
Suicide attempt 164.84 9.69 66 287197 54970 46343829
Red blood cell sedimentation rate abnormal 159.69 9.69 295 286968 13354 46385445
Musculoskeletal stiffness 157.56 9.69 1088 286175 96905 46301894
Product use issue 156.44 9.69 1058 286205 93586 46305213
Knee arthroplasty 154.00 9.69 404 286859 23261 46375538
Cardiac arrest 152.91 9.69 199 287064 90200 46308599
Injection site erythema 141.44 9.69 862 286401 73565 46325234
Acute kidney injury 134.62 9.69 874 286389 234981 46163818
Sickle cell anaemia with crisis 131.74 9.69 142 287121 3850 46394949
Discomfort 130.94 9.69 602 286661 46068 46352731
Drug hypersensitivity 129.98 9.69 922 286341 242903 46155896
Pregnancy 129.00 9.69 414 286849 26723 46372076
Febrile neutropenia 128.87 9.69 241 287022 94386 46304413
Injection site pain 125.28 9.69 1105 286158 106047 46292752
Device expulsion 113.42 9.69 17 287246 27525 46371274
Injection site pruritus 108.06 9.69 508 286755 39235 46359564
Depressed level of consciousness 106.44 9.69 82 287181 47487 46351312
Drug ineffective 106.23 9.69 5139 282124 672699 45726100
Arthritis 105.13 9.69 825 286438 76491 46322308
Abortion spontaneous 103.10 9.69 536 286727 43110 46355689
Therapeutic product effect decreased 101.32 9.69 861 286402 81740 46317059
Bradycardia 100.18 9.69 158 287105 66140 46332659
Blood pressure fluctuation 99.33 9.69 411 286852 30037 46368762
Psoriatic arthropathy 98.90 9.69 465 286798 35914 46362885
Lactic acidosis 97.78 9.69 43 287220 33866 46364933
Respiratory arrest 92.69 9.69 46 287217 33770 46365029
Hyponatraemia 92.23 9.69 317 286946 101015 46297784
Injection site swelling 90.97 9.69 489 286774 39838 46358961
Malignant neoplasm progression 90.47 9.69 163 287100 64763 46334036
Cardiac failure 89.49 9.69 227 287036 79721 46319078
Injection site reaction 89.49 9.69 552 286711 47297 46351502
Electrocardiogram QT prolonged 86.74 9.69 113 287150 51212 46347587
Disease progression 86.25 9.69 281 286982 91019 46307780
Osteoarthritis 84.40 9.69 662 286601 61363 46337436
Treatment failure 84.26 9.69 910 286353 92177 46306622
Confusional state 83.46 9.69 608 286655 159284 46239515
Anxiety 83.35 9.69 717 286546 181240 46217559
Duodenal ulcer perforation 82.69 9.69 170 287093 8332 46390467
Basal cell carcinoma 78.55 9.69 291 286972 20196 46378603
Helicobacter infection 78.03 9.69 202 287061 11534 46387265
Dyspnoea 77.66 9.69 2500 284763 513048 45885751
Renal failure 74.20 9.69 403 286860 113191 46285608
Drug reaction with eosinophilia and systemic symptoms 74.01 9.69 45 287218 29503 46369296
Sopor 73.52 9.69 16 287247 19812 46378987
Agitation 72.91 9.69 144 287119 55271 46343528
Cardio-respiratory arrest 72.55 9.69 163 287100 59706 46339093
Tremor 72.40 9.69 416 286847 115223 46283576
Intentional self-injury 72.32 9.69 29 287234 24137 46374662
Joint effusion 72.21 9.69 199 287064 11796 46387003
Product quality issue 71.75 9.69 68 287195 35580 46363219
Rhabdomyolysis 70.07 9.69 93 287170 41816 46356983
Caesarean section 69.76 9.69 243 287020 16360 46382439
Disability assessment scale score increased 69.49 9.69 77 287186 2155 46396644
Neutropenia 67.94 9.69 559 286704 142645 46256154
Dizziness 65.69 9.69 1594 285669 338820 46059979
Drug withdrawal syndrome 64.11 9.69 45 287218 27339 46371460
Multiple sclerosis relapse 64 9.69 100 287163 42025 46356774
Sinusitis 63.19 9.69 1136 286127 128632 46270167
Lower respiratory tract infection 62.22 9.69 564 286699 54525 46344274
Somnolence 62.13 9.69 639 286624 155882 46242917
Asthma 61.31 9.69 322 286941 91220 46307579
Joint laxity 59.62 9.69 69 287194 2027 46396772
Impaired healing 59.60 9.69 409 286854 36334 46362465
Psoriasis 59.33 9.69 742 286521 77862 46320937
Constipation 59.18 9.69 736 286527 173361 46225438
Live birth 58.87 9.69 168 287095 10162 46388637
Hepatic enzyme increased 58.75 9.69 765 286498 81022 46317777
Injection site bruising 58.59 9.69 398 286865 35238 46363561
Localised infection 58.08 9.69 295 286968 23506 46375293
Nausea 57.60 9.69 3556 283707 683898 45714901
Hypotension 57.48 9.69 1046 286217 231543 46167256
Red blood cell sedimentation rate increased 56.77 9.69 285 286978 22604 46376195
Blood pressure diastolic abnormal 55.59 9.69 121 287142 6173 46392626
Osteoporosis 54.45 9.69 432 286831 40176 46358623
Premature labour 54.25 9.69 173 287090 11126 46387673
Neoplasm progression 53.58 9.69 51 287212 26632 46372167
Sedation 53.17 9.69 38 287225 22872 46375927
Insomnia 51.36 9.69 710 286553 164214 46234585
Injection site rash 51.21 9.69 213 287050 15600 46383199
Maternal drugs affecting foetus 50.94 9.69 108 287155 5410 46393389
Tachycardia 50.90 9.69 381 286882 99241 46299558
Loss of personal independence in daily activities 50.79 9.69 557 286706 56626 46342173
Rheumatoid nodule 50.73 9.69 146 287117 8874 46389925
Pre-eclampsia 50.50 9.69 135 287128 7859 46390940
Delirium 50.49 9.69 95 287168 37133 46361666
Pulmonary arterial hypertension 50.40 9.69 51 287212 25877 46372922
Drug dependence 50.27 9.69 30 287233 19871 46378928
Oropharyngeal pain 49.65 9.69 685 286578 73483 46325316
Intentional product misuse 49.55 9.69 138 287125 46990 46351809
No adverse event 49.44 9.69 84 287179 34147 46364652
Neck deformity 49.36 9.69 59 287204 1795 46397004
Coma 48.81 9.69 189 287074 58160 46340639
Hypoglycaemia 48.77 9.69 171 287092 54178 46344621
Asthenia 48.72 9.69 1500 285763 309575 46089224
Foetal exposure during pregnancy 48.54 9.69 340 286923 30407 46368392
Hepatic failure 48.26 9.69 82 287181 33334 46365465
Juvenile idiopathic arthritis 47.94 9.69 89 287174 4043 46394756
Serotonin syndrome 47.81 9.69 47 287216 24173 46374626
Cholestasis 46.69 9.69 58 287205 26835 46371964
Gestational diabetes 45.69 9.69 122 287141 7097 46391702
Encephalopathy 45.30 9.69 86 287177 33503 46365296
Musculoskeletal pain 45.06 9.69 643 286620 69485 46329314
Poisoning 44.90 9.69 15 287248 13979 46384820
Condition aggravated 44.82 9.69 1889 285374 243163 46155636
Drug intolerance 43.79 9.69 1200 286063 145849 46252950
Palmar-plantar erythrodysaesthesia syndrome 43.56 9.69 37 287226 20414 46378385
Hyperhidrosis 43.53 9.69 346 286917 88962 46309837
Herpes zoster 43.48 9.69 622 286641 67250 46331549
Renal impairment 43.14 9.69 274 286989 74098 46324701
Blood pressure systolic abnormal 43.08 9.69 101 287162 5416 46393383
Neuropathy peripheral 42.99 9.69 355 286908 90538 46308261
Tuberculosis 42.92 9.69 150 287113 10115 46388684
Foot deformity 42.52 9.69 198 287065 15227 46383572
Pain in extremity 42.45 9.69 1972 285291 256708 46142091
Hepatocellular injury 42.12 9.69 73 287190 29449 46369350
Hyperglycaemia 42.06 9.69 96 287167 34975 46363824
Metabolic acidosis 41.93 9.69 112 287151 38668 46360131
Joint stiffness 41.76 9.69 298 286965 26810 46371989
Therapeutic response decreased 41.46 9.69 427 286836 42718 46356081
Cytomegalovirus infection 40.93 9.69 31 287232 18113 46380686
Diarrhoea 40.45 9.69 2932 284331 556670 45842129
Bone erosion 40.36 9.69 139 287124 9304 46389495
Product use in unapproved indication 40.27 9.69 358 286905 89915 46308884
Vomiting 40.10 9.69 2329 284934 450465 45948334
Plasma cell myeloma 39.87 9.69 140 287123 44338 46354461
Altered state of consciousness 39.86 9.69 51 287212 23297 46375502
Disturbance in attention 39.82 9.69 84 287179 31476 46367323
Premature delivery 39.63 9.69 252 287011 21817 46376982
Blood pressure systolic increased 39.55 9.69 308 286955 28479 46370320
Drug resistance 38.77 9.69 30 287233 17338 46381461
Myalgia 38.62 9.69 529 286734 122559 46276240
Skin ulcer 38.54 9.69 336 286927 32122 46366677
Hallucination 37.91 9.69 168 287095 49783 46349016
Limb deformity 37.76 9.69 74 287189 3502 46395297
Infective pulmonary exacerbation of cystic fibrosis 37.56 9.69 10 287253 10797 46388002
Restlessness 37.44 9.69 62 287201 25462 46373337
Ventricular septal defect 37.29 9.69 79 287184 3955 46394844
Nodule 37.08 9.69 192 287071 15413 46383386
Cardiac failure congestive 37.02 9.69 373 286890 91377 46307422
Emotional distress 36.87 9.69 84 287179 30623 46368176
Hepatic function abnormal 36.77 9.69 100 287163 34321 46364478
Blood pressure diastolic decreased 36.70 9.69 179 287084 14032 46384767
Hyperkalaemia 35.85 9.69 175 287088 50534 46348265
Small for dates baby 35.70 9.69 73 287190 3564 46395235
Fatigue 35.63 9.69 4270 282993 604427 45794372
Influenza 35.49 9.69 758 286505 88512 46310287
Hypoxia 35.45 9.69 181 287082 51657 46347142
Inflammation 35.31 9.69 457 286806 48324 46350475
Osteonecrosis of jaw 35.23 9.69 102 287161 34300 46364499
Diabetic ketoacidosis 35.18 9.69 36 287227 18174 46380625
Malignant melanoma 34.84 9.69 140 287123 10094 46388705
Fibromyalgia 34.62 9.69 360 286903 36103 46362696
Oral herpes 34.56 9.69 221 287042 19169 46379630
Femur fracture 34.53 9.69 364 286899 36633 46362166
Injection site warmth 34.51 9.69 172 287091 13600 46385199
Grip strength decreased 34.47 9.69 124 287139 8482 46390317
Mydriasis 34.41 9.69 11 287252 10542 46388257
Peripheral swelling 34.40 9.69 1242 286021 156829 46241970
Arthritis infective 33.98 9.69 88 287175 5025 46393774
Disorientation 33.90 9.69 115 287148 36803 46361996
Shock 33.04 9.69 52 287211 21793 46377006
Heart rate decreased 32.91 9.69 319 286944 31404 46367395
Smear cervix abnormal 32.78 9.69 57 287206 2459 46396340
Syncope 32.66 9.69 451 286812 104352 46294447
General physical health deterioration 32.33 9.69 509 286754 115260 46283539
Neck mass 32.21 9.69 66 287197 3227 46395572
Ejection fraction decreased 31.86 9.69 38 287225 17899 46380900
Multiple organ dysfunction syndrome 31.82 9.69 187 287076 51523 46347276
Bronchitis 31.57 9.69 865 286398 105114 46293685
Enthesopathy 31.46 9.69 81 287182 4609 46394190
Developmental hip dysplasia 31.20 9.69 39 287224 1244 46397555
Urticaria 31.05 9.69 524 286739 117368 46281431
Weight increased 30.74 9.69 1271 285992 163202 46235597
Joint destruction 30.67 9.69 62 287201 3002 46395797
Blood glucose increased 30.63 9.69 289 286974 71724 46327075
Premature rupture of membranes 30.30 9.69 77 287186 4346 46394453
Blood pressure diastolic increased 30.09 9.69 93 287170 5881 46392918
Blood creatine phosphokinase increased 30.02 9.69 80 287183 27644 46371155
Hypokalaemia 29.92 9.69 372 286891 87652 46311147
Respiratory failure 29.91 9.69 407 286856 94409 46304390
Rash 29.57 9.69 2562 284701 353950 46044849
Seizure 29.54 9.69 556 286707 122498 46276301
Joint injury 29.49 9.69 211 287052 18998 46379801
Dyspnoea exertional 29.30 9.69 185 287078 50104 46348695
Multiple fractures 29.29 9.69 88 287175 5479 46393320
Abnormal behaviour 29.20 9.69 53 287210 21005 46377794
Posterior reversible encephalopathy syndrome 29.18 9.69 30 287233 15111 46383688
Anaphylactic reaction 29.12 9.69 199 287064 52913 46345886
Metastases to bone 28.99 9.69 39 287224 17437 46381362
Mental status changes 28.96 9.69 128 287135 37960 46360839
Loss of consciousness 28.86 9.69 480 286783 107758 46291041
Fluid retention 28.61 9.69 190 287073 50856 46347943
Postoperative wound infection 28.42 9.69 118 287145 8635 46390164
Swollen joint count increased 28.23 9.69 52 287211 2348 46396451
Pulmonary embolism 28.15 9.69 484 286779 108101 46290698
Depression 28.12 9.69 814 286449 169290 46229509
Tenderness 28.02 9.69 189 287074 16692 46382107
Joint range of motion decreased 27.96 9.69 174 287089 14950 46383849
Skin papilloma 27.89 9.69 72 287191 4104 46394695
Tenosynovitis stenosans 27.84 9.69 46 287217 1903 46396896
Speech disorder 27.83 9.69 121 287142 36046 46362753
Rheumatic fever 27.83 9.69 57 287206 2786 46396013
Decreased appetite 27.59 9.69 946 286317 192890 46205909
Hypothermia 27.25 9.69 21 287242 12162 46386637
Respiratory depression 27.23 9.69 19 287244 11581 46387218
Synovial cyst 27.04 9.69 103 287160 7243 46391556
Feeling abnormal 26.74 9.69 576 286687 124484 46274315
Cellulitis 26.71 9.69 593 286670 69695 46329104
Gastroenteritis viral 26.65 9.69 197 287066 17922 46380877
Gamma-glutamyltransferase increased 26.41 9.69 103 287160 31637 46367162
Unresponsive to stimuli 26.40 9.69 105 287158 32069 46366730
Schizophrenia 26.10 9.69 10 287253 8558 46390241
Ventricular tachycardia 26.03 9.69 40 287223 16927 46381872
Drug level increased 25.94 9.69 46 287217 18395 46380404
Thrombocytopenia 25.92 9.69 587 286676 125994 46272805
Muscle spasms 25.75 9.69 569 286694 122544 46276255
Neutrophil count decreased 25.69 9.69 159 287104 43267 46355532
Polyhydramnios 25.67 9.69 45 287218 1954 46396845
Cognitive disorder 25.66 9.69 128 287135 36755 46362044
Cerebral haemorrhage 25.62 9.69 89 287174 28282 46370517
Skin cancer 25.62 9.69 115 287148 8708 46390091
Acute generalised exanthematous pustulosis 25.46 9.69 13 287250 9392 46389407
Placental disorder 25.36 9.69 37 287226 1372 46397427
Disseminated intravascular coagulation 25.33 9.69 49 287214 18956 46379843
Contusion 25.19 9.69 711 286552 86776 46312023
Myocardial infarction 25.19 9.69 435 286828 97093 46301706
Pulmonary tuberculosis 25.09 9.69 75 287188 4656 46394143
Latent tuberculosis 25.01 9.69 44 287219 1916 46396883
Suicidal ideation 24.96 9.69 224 287039 56158 46342641
Blood pressure decreased 24.91 9.69 228 287035 56931 46341868
Torsade de pointes 24.67 9.69 23 287240 12131 46386668
Surgery 24.46 9.69 278 286985 28507 46370292
Product administration error 24.31 9.69 53 287210 19628 46379171
Ventricular fibrillation 24.24 9.69 21 287242 11475 46387324
Fracture 24.18 9.69 179 287084 16292 46382507
Disability 24.09 9.69 125 287138 10042 46388757
Angioedema 23.82 9.69 143 287120 39199 46359600
Polyarthritis 23.48 9.69 91 287172 6451 46392348
Extrapyramidal disorder 23.26 9.69 21 287242 11247 46387552
Psychotic disorder 23.21 9.69 67 287196 22554 46376245
Foetal death 23.20 9.69 111 287152 8632 46390167
Anaphylactic shock 23.11 9.69 57 287206 20217 46378582
Synovial fluid analysis 23.08 9.69 35 287228 1344 46397455
Injection site haemorrhage 22.85 9.69 211 287052 20498 46378301
Blood creatinine increased 22.66 9.69 332 286931 76071 46322728
Squamous cell carcinoma 22.65 9.69 102 287161 7734 46391065
Febrile bone marrow aplasia 22.65 9.69 7 287256 6855 46391944
Neuroleptic malignant syndrome 22.63 9.69 21 287242 11101 46387698
Immune reconstitution inflammatory syndrome 22.53 9.69 4 287259 5721 46393078
Metastases to liver 22.37 9.69 55 287208 19530 46379269
Dysarthria 22.33 9.69 137 287126 37361 46361438
Acute hepatic failure 22.30 9.69 35 287228 14686 46384113
Mouth ulceration 22.29 9.69 258 287005 26574 46372225
Cystitis 22.04 9.69 374 286889 41867 46356932
Pancytopenia 21.97 9.69 682 286581 84376 46314423
Anaemia 21.96 9.69 1319 285944 254460 46144339
Injection site haematoma 21.92 9.69 85 287178 6027 46392772
Acute chest syndrome 21.90 9.69 22 287241 548 46398251
Hypersensitivity 21.90 9.69 1133 286130 149188 46249611
Akathisia 21.89 9.69 10 287253 7704 46391095
Atrial septal defect 21.86 9.69 87 287176 6245 46392554
Body height below normal 21.83 9.69 40 287223 1799 46397000
Vertigo 21.65 9.69 210 287053 51838 46346961
Memory impairment 21.59 9.69 340 286923 76997 46321802
Brain oedema 21.57 9.69 27 287236 12451 46386348
Antinuclear antibody positive 21.45 9.69 86 287177 6194 46392605
Blood alkaline phosphatase increased 21.42 9.69 149 287114 39460 46359339
Neurotoxicity 21.37 9.69 32 287231 13685 46385114
Blood bilirubin increased 21.36 9.69 123 287140 34061 46364738
Immunodeficiency 21.31 9.69 146 287117 12960 46385839
Chest discomfort 21.30 9.69 409 286854 89860 46308939
Nightmare 21.09 9.69 44 287219 16554 46382245
Inappropriate antidiuretic hormone secretion 20.92 9.69 34 287229 14068 46384731
Accidental overdose 20.91 9.69 59 287204 20007 46378792
Loose body in joint 20.88 9.69 29 287234 1027 46397772
Gestational hypertension 20.85 9.69 43 287220 2112 46396687
Complication of device insertion 20.47 9.69 3 287260 4941 46393858
Immunosuppression 20.47 9.69 96 287167 7404 46391395
Diabetes mellitus inadequate control 20.42 9.69 31 287232 13183 46385616
Arrhythmia 20.38 9.69 128 287135 34713 46364086
Clear cell renal cell carcinoma 20.17 9.69 28 287235 991 46397808
Jaundice 20.12 9.69 100 287163 28745 46370054
Ascites 20.09 9.69 137 287126 36447 46362352
Hospitalisation 20.01 9.69 272 286991 63113 46335686
Respiratory disorder 20.00 9.69 93 287170 27207 46371592
Aspartate aminotransferase increased 20.00 9.69 352 286911 78348 46320451
Atrioventricular block complete 19.97 9.69 11 287252 7616 46391183
Cushingoid 19.97 9.69 84 287179 6182 46392617
Blood pressure increased 19.95 9.69 962 286301 125704 46273095
Breast feeding 19.91 9.69 26 287237 867 46397932
Infection 19.88 9.69 1009 286254 132583 46266216
Vision blurred 19.79 9.69 358 286905 79350 46319449
Transplant rejection 19.67 9.69 18 287245 9578 46389221
Dysgeusia 19.66 9.69 157 287106 40334 46358465
Fear 19.61 9.69 44 287219 16128 46382671
Congenital arterial malformation 19.58 9.69 17 287246 350 46398449
Muscle spasticity 19.52 9.69 25 287238 11415 46387384
Bradyphrenia 19.43 9.69 7 287256 6223 46392576
Cytokine release syndrome 19.40 9.69 7 287256 6216 46392583
Polyneuropathy 19.30 9.69 26 287237 11618 46387181
Deep vein thrombosis 19.27 9.69 360 286903 79413 46319386
Balance disorder 19.26 9.69 280 286983 64241 46334558
Scleritis 19.23 9.69 50 287213 2862 46395937
Haemoglobin decreased 19.20 9.69 974 286289 127975 46270824
Injection site irritation 19.11 9.69 64 287199 4223 46394576
Multiple sclerosis 19.04 9.69 83 287180 24708 46374091
Laryngitis 19.02 9.69 110 287153 9206 46389593
Wheelchair user 18.91 9.69 61 287202 3947 46394852
Pulmonary fibrosis 18.89 9.69 198 287065 19894 46378905
Spinal stenosis 18.80 9.69 137 287126 12406 46386393
Respiratory distress 18.80 9.69 117 287146 31799 46367000
Crying 18.64 9.69 67 287196 21074 46377725
Fluid overload 18.54 9.69 95 287168 27090 46371709
Pain in jaw 18.53 9.69 149 287114 38223 46360576
Antibody test positive 18.42 9.69 41 287222 2124 46396675
Asphyxia 18.37 9.69 5 287258 5321 46393478
Wheezing 18.37 9.69 225 287038 53161 46345638
Arthritis bacterial 18.36 9.69 77 287186 5659 46393140
Oedema 18.34 9.69 296 286967 66775 46332024
Joint noise 18.32 9.69 52 287211 3135 46395664
Tooth infection 18.31 9.69 134 287129 12152 46386647
Palpitations 18.31 9.69 446 286817 94813 46303986
Dry eye 18.27 9.69 275 286988 30047 46368752
Poor venous access 18.22 9.69 100 287163 8208 46390591
Synovial disorder 17.98 9.69 24 287239 818 46397981
C-reactive protein increased 17.94 9.69 480 286783 58110 46340689
Agranulocytosis 17.82 9.69 73 287190 22112 46376687
Serum ferritin increased 17.77 9.69 72 287191 5211 46393588
Bone disorder 17.71 9.69 195 287068 19838 46378961
Stillbirth 17.66 9.69 83 287180 6408 46392391
Leukopenia 17.58 9.69 305 286958 68038 46330761
Ischaemic stroke 17.55 9.69 49 287214 16673 46382126
Bone pain 17.54 9.69 194 287069 46696 46352103
Injection site urticaria 17.54 9.69 130 287133 11837 46386962
Exomphalos 17.48 9.69 19 287244 520 46398279
Hypomania 17.41 9.69 3 287260 4385 46394414
Human antichimeric antibody positive 17.38 9.69 31 287232 1365 46397434
Device dislocation 17.35 9.69 72 287191 21730 46377069
Bronchospasm 17.25 9.69 45 287218 15662 46383137
Talipes 17.20 9.69 31 287232 1376 46397423
Dyskinesia 17.06 9.69 106 287157 28819 46369980
Diverticulitis 17.04 9.69 292 286971 32747 46366052
Withdrawal syndrome 16.98 9.69 56 287207 18078 46380721
Status epilepticus 16.98 9.69 38 287225 13941 46384858
Chronic kidney disease 16.96 9.69 165 287098 40706 46358093
Cervical incompetence 16.87 9.69 20 287243 603 46398196
Post procedural infection 16.86 9.69 91 287172 7422 46391377
Cerebrovascular accident 16.81 9.69 483 286780 100556 46298243
Premature baby 16.80 9.69 178 287085 17934 46380865
Dehydration 16.80 9.69 806 286457 158734 46240065
Coagulopathy 16.73 9.69 58 287205 18441 46380358
Cholestasis of pregnancy 16.69 9.69 27 287236 1097 46397702
Pharyngitis streptococcal 16.65 9.69 99 287164 8369 46390430
Irritability 16.59 9.69 107 287156 28839 46369960
Graft versus host disease 16.54 9.69 10 287253 6578 46392221
Thrombotic microangiopathy 16.53 9.69 16 287247 8290 46390509
Injury 16.53 9.69 182 287081 43845 46354954
Alanine aminotransferase increased 16.49 9.69 416 286847 88035 46310764
Bone density abnormal 16.46 9.69 49 287214 3035 46395764
Toxic skin eruption 16.45 9.69 32 287231 12355 46386444
Product adhesion issue 16.45 9.69 5 287258 4950 46393849
Haemorrhage 16.42 9.69 238 287025 54631 46344168
White blood cell count decreased 16.35 9.69 546 286717 111685 46287114
Skin laceration 16.31 9.69 180 287083 18322 46380477
Eosinophilia 16.22 9.69 62 287201 19155 46379644
Anhedonia 16.21 9.69 24 287239 10311 46388488
Substance abuse 16.20 9.69 3 287260 4164 46394635
Tenosynovitis 16.18 9.69 90 287173 7425 46391374
Foot fracture 16.14 9.69 188 287075 19394 46379405
Bursitis 16.13 9.69 190 287073 19652 46379147
Joint dislocation 16.10 9.69 121 287142 11065 46387734
Knee operation 16.06 9.69 65 287198 4701 46394098
Paralysis 16.00 9.69 18 287245 8703 46390096
Rotator cuff repair 15.98 9.69 31 287232 1456 46397343
Hallucination, auditory 15.89 9.69 26 287237 10730 46388069
Blood iron increased 15.86 9.69 29 287234 1302 46397497
Foetal distress syndrome 15.82 9.69 28 287235 1225 46397574
Pancreatitis acute 15.80 9.69 89 287174 24783 46374016
Injection site extravasation 15.79 9.69 83 287180 6702 46392097
Aggression 15.78 9.69 79 287184 22665 46376134
Metastases to central nervous system 15.78 9.69 28 287235 11193 46387606
Hiatus hernia 15.66 9.69 177 287086 18125 46380674
Maternal exposure during breast feeding 15.54 9.69 45 287218 2744 46396055
Dactylitis 15.51 9.69 27 287236 1166 46397633
Miosis 15.50 9.69 11 287252 6646 46392153
Stress cardiomyopathy 15.48 9.69 15 287248 7769 46391030
Acute graft versus host disease 15.46 9.69 3 287260 4027 46394772
Pyrexia 15.42 9.69 1895 285368 346907 46051892
Cytopenia 15.42 9.69 15 287248 7753 46391046
Face oedema 15.40 9.69 63 287200 19090 46379709
Psychomotor hyperactivity 15.39 9.69 22 287241 9591 46389208
Device use error 15.36 9.69 6 287257 5075 46393724
Mania 15.31 9.69 27 287236 10819 46387980
Device difficult to use 15.26 9.69 16 287247 7988 46390811
Carpal tunnel syndrome 15.25 9.69 157 287106 15702 46383097
Melaena 15.25 9.69 104 287159 27668 46371131
Joint lock 15.18 9.69 37 287226 2034 46396765
Haemorrhage in pregnancy 15.18 9.69 32 287231 1596 46397203
Second primary malignancy 15.17 9.69 11 287252 6573 46392226
Breast cancer metastatic 15.17 9.69 39 287224 13639 46385160
Obstructive airways disorder 15.06 9.69 38 287225 13374 46385425
Ketoacidosis 15.06 9.69 3 287260 3952 46394847
Eye infection 15.06 9.69 102 287161 9021 46389778
Fracture delayed union 14.96 9.69 38 287225 2144 46396655
Atrioventricular block 14.90 9.69 12 287251 6799 46392000
Erythema multiforme 14.77 9.69 23 287240 9681 46389118
Induced labour 14.64 9.69 23 287240 911 46397888
Acute respiratory failure 14.60 9.69 112 287151 29026 46369773
Pleuritic pain 14.60 9.69 78 287185 6338 46392461
Acute myeloid leukaemia 14.58 9.69 49 287214 15729 46383070
Tardive dyskinesia 14.47 9.69 15 287248 7528 46391271
Off label use 14.47 9.69 2083 285180 377758 46021041
Viral infection 14.45 9.69 264 286999 29971 46368828
Sickle cell anaemia 14.40 9.69 18 287245 574 46398225
Lupus-like syndrome 14.35 9.69 90 287173 7754 46391045
Joint warmth 14.34 9.69 27 287236 1240 46397559
Ingrown hair 14.32 9.69 16 287247 452 46398347
Platelet count decreased 14.25 9.69 488 286775 99536 46299263
Maternal exposure before pregnancy 14.23 9.69 60 287203 4421 46394378
Cyst 14.23 9.69 125 287138 11975 46386824
Lymphoma 14.04 9.69 106 287157 9707 46389092
Body temperature decreased 13.99 9.69 135 287128 13274 46385525
Lymphadenectomy 13.96 9.69 22 287241 874 46397925
Lung neoplasm malignant 13.80 9.69 151 287112 15338 46383461
Injection site induration 13.74 9.69 91 287172 7988 46390811
Tendon disorder 13.68 9.69 64 287199 4931 46393868
Glycosylated haemoglobin increased 13.67 9.69 29 287234 10847 46387952
Myoclonus 13.66 9.69 44 287219 14308 46384491
Abortion missed 13.63 9.69 30 287233 1542 46397257
Weight decreased 13.43 9.69 1488 285775 209361 46189438
Pulmonary hypertension 13.42 9.69 149 287114 35844 46362955
Sedation complication 13.39 9.69 3 287260 3642 46395157
Red blood cell sedimentation rate 13.35 9.69 32 287231 1741 46397058
Hypomagnesaemia 13.30 9.69 81 287182 22129 46376670
Atrial fibrillation 13.26 9.69 512 286751 103078 46295721
Tumour lysis syndrome 13.21 9.69 15 287248 7221 46391578
Cholecystitis chronic 13.20 9.69 28 287235 10471 46388328
Drug ineffective for unapproved indication 13.19 9.69 54 287209 16359 46382440
Pulmonary oedema 13.17 9.69 228 287035 50877 46347922
Pancreatitis 13.14 9.69 189 287074 43438 46355361
Cardiogenic shock 13.11 9.69 54 287209 16330 46382469
Incorrect route of product administration 13.10 9.69 54 287209 16329 46382470
Panic attack 13.10 9.69 72 287191 20170 46378629
Cerebral infarction 13.08 9.69 87 287176 23279 46375520
Autism spectrum disorder 13.06 9.69 17 287246 565 46398234
Foetal anticonvulsant syndrome 12.95 9.69 15 287248 441 46398358
Anterior chamber cleavage syndrome 12.92 9.69 10 287253 174 46398625
Parkinsonism 12.92 9.69 18 287245 7930 46390869
Wound infection pseudomonas 12.88 9.69 28 287235 1427 46397372
Ear infection 12.83 9.69 206 287057 22807 46375992
Limb injury 12.78 9.69 177 287086 18997 46379802
Chest pain 12.78 9.69 923 286340 175401 46223398
Skin infection 12.75 9.69 116 287147 11223 46387576
Upper respiratory tract infection 12.75 9.69 495 286768 63061 46335738
Orthostatic hypotension 12.73 9.69 94 287169 24564 46374235
Wrong technique in product usage process 12.71 9.69 247 287016 54175 46344624
Myopathy 12.63 9.69 22 287241 8859 46389940
Ulcer 12.61 9.69 163 287100 17229 46381570
Post transplant lymphoproliferative disorder 12.61 9.69 4 287259 3852 46394947
Shock haemorrhagic 12.60 9.69 21 287242 8603 46390196
Crohn's disease 12.58 9.69 78 287185 6693 46392106
Lymphatic fistula 12.56 9.69 21 287242 877 46397922
Hypertransaminasaemia 12.56 9.69 3 287260 3485 46395314
Lung neoplasm 12.53 9.69 69 287194 5671 46393128
Uterine contractions during pregnancy 12.52 9.69 16 287247 522 46398277
Rhinorrhoea 12.52 9.69 383 286880 47282 46351517
Crystal nephropathy 12.50 9.69 20 287243 805 46397994
Forceps delivery 12.50 9.69 10 287253 183 46398616
Pemphigoid 12.49 9.69 10 287253 5681 46393118
Human anti-human antibody test 12.46 9.69 13 287250 339 46398460
Cardiac failure acute 12.44 9.69 19 287244 8059 46390740
Foetal growth restriction 12.42 9.69 76 287187 6491 46392308
Femoral hernia incarcerated 12.38 9.69 21 287242 888 46397911
Renal injury 12.37 9.69 25 287238 9516 46389283
Proteinuria 12.36 9.69 56 287207 16497 46382302
Placental insufficiency 12.23 9.69 26 287237 1305 46397494
Labyrinthitis 12.13 9.69 34 287229 2035 46396764
Hemiparesis 12.12 9.69 73 287190 19996 46378803
Pancreatic steatosis 12.11 9.69 22 287241 983 46397816
Hyperuricaemia 12.07 9.69 7 287256 4710 46394089
Vacuum extractor delivery 12.05 9.69 9 287254 148 46398651
Renal mass 12.01 9.69 31 287232 1767 46397032
Nail injury 12.00 9.69 14 287249 415 46398384
Mass 12.00 9.69 117 287146 11536 46387263
Haematotoxicity 11.98 9.69 15 287248 6918 46391881
Hyperlipidaemia 11.96 9.69 66 287197 18473 46380326
Transplant dysfunction 11.91 9.69 7 287256 4675 46394124
Endodontic procedure 11.89 9.69 38 287225 2447 46396352
Dysmorphism 11.84 9.69 32 287231 1875 46396924
Vascular rupture 11.83 9.69 25 287238 1249 46397550
Aspergillus infection 11.81 9.69 15 287248 6875 46391924
Flushing 11.74 9.69 305 286958 64309 46334490
Tonsillitis 11.74 9.69 61 287202 4903 46393896
Intervertebral disc degeneration 11.72 9.69 129 287134 13123 46385676
Normal newborn 11.70 9.69 70 287193 5931 46392868
Myofascial pain syndrome 11.69 9.69 32 287231 1889 46396910
Pathogen resistance 11.68 9.69 12 287251 6048 46392751
Frequent bowel movements 11.65 9.69 124 287139 12508 46386291
Abdominal distension 11.61 9.69 353 286910 72998 46325801
Subdural haematoma 11.58 9.69 41 287222 12956 46385843
Inflammatory pain 11.58 9.69 17 287246 634 46398165
Drug-induced liver injury 11.57 9.69 100 287163 25268 46373531
Genital haemorrhage 11.57 9.69 14 287249 6552 46392247
Haemophagocytic lymphohistiocytosis 11.56 9.69 21 287242 8321 46390478
Acidosis 11.53 9.69 33 287230 11141 46387658
Colitis microscopic 11.53 9.69 14 287249 6542 46392257
Ankylosing spondylitis 11.52 9.69 76 287187 6661 46392138
Pleural effusion 11.51 9.69 406 286857 82546 46316253
Metastases to lung 11.48 9.69 31 287232 10665 46388134
Neonatal respiratory distress syndrome 11.45 9.69 38 287225 2495 46396304
Haemorrhage intracranial 11.43 9.69 40 287223 12684 46386115
Bone marrow failure 11.39 9.69 122 287141 29547 46369252
Mycobacterium tuberculosis complex test positive 11.37 9.69 28 287235 1550 46397249
Hallucination, visual 11.33 9.69 64 287199 17809 46380990
Disseminated tuberculosis 11.32 9.69 40 287223 2712 46396087
Oliguria 11.31 9.69 23 287240 8736 46390063
Photophobia 11.27 9.69 138 287125 14406 46384393
Haematocrit decreased 11.25 9.69 289 286974 34768 46364031
Drug abuser 11.22 9.69 3 287260 3230 46395569
Myocarditis 11.16 9.69 19 287244 7720 46391079
Abortion threatened 11.16 9.69 16 287247 584 46398215
Wound infection 11.15 9.69 105 287158 10254 46388545
Cartilage injury 11.15 9.69 28 287235 1569 46397230
Large for dates baby 11.14 9.69 14 287249 449 46398350
Carcinoma in situ of skin 11.12 9.69 10 287253 216 46398583
Dysphagia 11.05 9.69 377 286886 76935 46321864
Congenital hydronephrosis 11.02 9.69 13 287250 390 46398409
Mood altered 10.96 9.69 42 287221 12965 46385834
Failed induction of labour 10.91 9.69 12 287251 333 46398466
International normalised ratio increased 10.88 9.69 213 287050 46670 46352129
Delusion 10.86 9.69 34 287229 11154 46387645
Incorrect product administration duration 10.86 9.69 27 287236 9550 46389249
Aortic valve stenosis 10.84 9.69 43 287220 3081 46395718
Stress at work 10.83 9.69 21 287242 986 46397813
Oligohydramnios 10.82 9.69 64 287199 5401 46393398
Infusion site erythema 10.81 9.69 19 287244 7623 46391176
Decreased insulin requirement 10.74 9.69 8 287255 131 46398668
Catheter site pain 10.70 9.69 5 287258 3801 46394998
Arthropod bite 10.67 9.69 67 287196 5774 46393025
Unevaluable event 10.65 9.69 210 287053 45965 46352834
Joint arthroplasty 10.62 9.69 32 287231 1995 46396804
Nervousness 10.57 9.69 118 287145 28357 46370442
Stevens-Johnson syndrome 10.55 9.69 92 287171 23205 46375594
Complication associated with device 10.50 9.69 54 287209 15387 46383412
Sinus tachycardia 10.48 9.69 84 287179 21565 46377234
Device breakage 10.47 9.69 28 287235 9664 46389135
Tubulointerstitial nephritis 10.47 9.69 51 287212 14737 46384062
Kidney infection 10.40 9.69 153 287110 16636 46382163
Ill-defined disorder 10.40 9.69 227 287036 26600 46372199
Nodal osteoarthritis 10.36 9.69 18 287245 776 46398023
Bowen's disease 10.33 9.69 10 287253 238 46398561
Infusion site pain 10.32 9.69 30 287233 10077 46388722
Muscular weakness 10.26 9.69 461 286802 91383 46307416
Ileus paralytic 10.26 9.69 7 287256 4316 46394483
Inflammatory bowel disease 10.24 9.69 43 287220 3162 46395637
Chondropathy 10.23 9.69 31 287232 1939 46396860
Patent ductus arteriosus 10.23 9.69 49 287214 3813 46394986
Tuberculin test positive 10.15 9.69 41 287222 2963 46395836
Cold type haemolytic anaemia 10.14 9.69 9 287254 191 46398608
Product prescribing error 10.07 9.69 77 287186 19970 46378829
Rheumatoid lung 10.03 9.69 28 287235 1672 46397127
Impaired quality of life 9.98 9.69 43 287220 3199 46395600
Dermatitis allergic 9.94 9.69 120 287143 12483 46386316
Threatened labour 9.92 9.69 18 287245 803 46397996
Bundle branch block right 9.92 9.69 9 287254 4810 46393989
Therapy change 9.90 9.69 10 287253 5080 46393719
Bundle branch block left 9.90 9.69 15 287248 6384 46392415
Respiratory tract infection 9.89 9.69 248 287015 29724 46369075
Complication of pregnancy 9.89 9.69 14 287249 505 46398294
Tachypnoea 9.87 9.69 50 287213 14301 46384498
Respiration abnormal 9.85 9.69 8 287255 4513 46394286
Fear of injection 9.84 9.69 51 287212 4096 46394703
Intestinal stenosis 9.82 9.69 36 287227 2485 46396314
Pregnancy with contraceptive device 9.77 9.69 8 287255 4495 46394304
Cyst rupture 9.74 9.69 13 287250 443 46398356
Conjunctivitis 9.73 9.69 141 287122 15283 46383516
Gastroenteritis 9.73 9.69 206 287057 24013 46374786
Dystonia 9.71 9.69 36 287227 11221 46387578
Delivery 9.70 9.69 16 287247 661 46398138

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 463.29 9.92 700 122562 40497 29788719
Drug abuse 289.51 9.92 11 123251 82061 29747155
Foetal exposure during pregnancy 227.28 9.92 482 122780 36389 29792827
Arthralgia 204.30 9.92 1099 122163 134692 29694524
Completed suicide 200.90 9.92 79 123183 99413 29729803
Toxicity to various agents 189.79 9.92 272 122990 176911 29652305
Psoriatic arthropathy 126.12 9.92 230 123032 15531 29813685
Sickle cell anaemia with crisis 103.52 9.92 83 123179 2319 29826897
Joint swelling 103.48 9.92 425 122837 46521 29782695
Premature baby 95.70 9.92 212 123050 16479 29812737
Drug interaction 92.29 9.92 465 122797 199103 29630113
Exposure during pregnancy 86.91 9.92 145 123117 9116 29820100
Intentional overdose 81.92 9.92 34 123228 41447 29787769
Neonatal respiratory distress syndrome 74.12 9.92 87 123175 3925 29825291
Tenosynovitis 73.02 9.92 81 123181 3434 29825782
Atrial septal defect 69.79 9.92 110 123152 6591 29822625
Overdose 69.73 9.92 152 123110 84185 29745031
Enthesopathy 67.44 9.92 71 123191 2835 29826381
Nasopharyngitis 65.66 9.92 441 122821 58408 29770808
Blood pressure fluctuation 64.45 9.92 188 123074 17315 29811901
Death 61.23 9.92 1069 122193 356214 29473002
Maternal drugs affecting foetus 60.32 9.92 81 123181 4192 29825024
Musculoskeletal stiffness 56.22 9.92 294 122968 35587 29793629
Acute kidney injury 55.35 9.92 794 122468 273048 29556168
Suicide attempt 55.32 9.92 42 123220 36655 29792561
Hypospadias 54.39 9.92 61 123201 2618 29826598
Synovitis 53.55 9.92 122 123140 9661 29819555
Small for dates baby 48.67 9.92 63 123199 3145 29826071
Psoriasis 48.28 9.92 320 122942 42186 29787030
Maternal exposure during pregnancy 48.09 9.92 69 123193 3802 29825414
Tongue disorder 47.88 9.92 73 123189 4249 29824967
Low birth weight baby 47.75 9.92 88 123174 5988 29823228
Maternal exposure during breast feeding 47.32 9.92 45 123217 1587 29827629
Ventricular septal defect 46.95 9.92 65 123197 3464 29825752
Dysmorphism 46.31 9.92 49 123213 1968 29827248
C-reactive protein abnormal 45.21 9.92 82 123180 5511 29823705
Hypoglycaemia neonatal 44.67 9.92 43 123219 1540 29827676
Infusion related reaction 44.64 9.92 303 122959 40261 29788955
Haemoglobin decreased 43.05 9.92 684 122578 113414 29715802
Pain 42.78 9.92 970 122292 171671 29657545
Drug reaction with eosinophilia and systemic symptoms 42.43 9.92 33 123229 28455 29800761
Serotonin syndrome 41.73 9.92 11 123251 17880 29811336
Pulmonary fibrosis 41.63 9.92 152 123110 15738 29813478
Cryptorchism 40.76 9.92 42 123220 1635 29827581
Arthritis 40.35 9.92 203 123059 24198 29805018
Drug intolerance 39.96 9.92 321 122941 44970 29784246
Intentional product misuse 39.24 9.92 51 123211 34616 29794600
Lower respiratory tract infection 39.19 9.92 215 123047 26499 29802717
Pancytopenia 37.99 9.92 525 122737 84527 29744689
Hepatic function abnormal 37.70 9.92 72 123190 41873 29787343
Basal cell carcinoma 37.39 9.92 148 123114 15920 29813296
Drug resistance 37.39 9.92 18 123244 20115 29809101
Coma 35.86 9.92 70 123192 40379 29788837
Syndactyly 35.03 9.92 27 123235 711 29828505
Rhabdomyolysis 34.79 9.92 139 123123 63441 29765775
Blood pressure systolic increased 34.22 9.92 138 123124 14972 29814244
Exposure via breast milk 34.00 9.92 37 123225 1535 29827681
Arthropathy 33.96 9.92 172 123090 20555 29808661
Osteoarthritis 33.46 9.92 157 123105 18192 29811024
Product use in unapproved indication 33.23 9.92 173 123089 73520 29755696
Large for dates baby 33.17 9.92 28 123234 842 29828374
Drug withdrawal syndrome 32.05 9.92 21 123241 19788 29809428
Foetal anticonvulsant syndrome 31.78 9.92 26 123236 748 29828468
Alanine aminotransferase abnormal 30.10 9.92 45 123217 2574 29826642
Angioedema 30.05 9.92 60 123202 34324 29794892
Loss of personal independence in daily activities 30.05 9.92 171 123091 21364 29807852
Bradycardia 30.01 9.92 153 123109 65373 29763843
Renal failure 29.58 9.92 364 122898 128602 29700614
Blood pressure increased 28.93 9.92 436 122826 71492 29757724
Juvenile idiopathic arthritis 28.81 9.92 28 123234 1015 29828201
Intentional self-injury 28.52 9.92 10 123252 13522 29815694
Agitation 28.46 9.92 120 123142 53953 29775263
Blood pressure systolic abnormal 28.37 9.92 33 123229 1474 29827742
Suicidal ideation 28.27 9.92 67 123195 36047 29793169
Skin cancer 27.86 9.92 84 123178 7877 29821339
Drug dependence 27.70 9.92 28 123234 21267 29807949
Rheumatoid nodule 26.91 9.92 34 123228 1656 29827560
Cytomegalovirus infection 26.61 9.92 35 123227 23639 29805577
Congenital hand malformation 26.49 9.92 19 123243 447 29828769
Cardiac arrest 26.12 9.92 250 123012 92600 29736616
Lactic acidosis 25.98 9.92 56 123206 31157 29798059
Serum ferritin increased 25.64 9.92 64 123198 5373 29823843
Tendonitis 25.54 9.92 82 123180 7954 29821262
Musculoskeletal pain 25.52 9.92 216 123046 30724 29798492
Selective eating disorder 25.43 9.92 33 123229 1651 29827565
Knee arthroplasty 25.23 9.92 65 123197 5565 29823651
Palmar-plantar erythrodysaesthesia syndrome 25.11 9.92 15 123247 14855 29814361
Caesarean section 24.96 9.92 37 123225 2100 29827116
Peripheral swelling 24.87 9.92 371 122891 60703 29768513
Respiratory arrest 24.76 9.92 52 123210 29206 29800010
Injection site pain 24.68 9.92 211 123051 30099 29799117
Foetal growth restriction 24.58 9.92 49 123213 3536 29825680
Body temperature decreased 24.15 9.92 91 123171 9564 29819652
Medical device implantation 24.15 9.92 19 123243 516 29828700
Agitation neonatal 23.71 9.92 25 123237 1000 29828216
Arthritis bacterial 23.69 9.92 55 123207 4409 29824807
Poisoning 23 9.92 9 123253 11373 29817843
Cardiac failure 22.87 9.92 226 123036 83192 29746024
Hypoglycaemia 22.79 9.92 120 123142 50861 29778355
Pain in extremity 22.66 9.92 604 122658 109617 29719599
Febrile neutropenia 22.65 9.92 306 122956 106387 29722829
Infective pulmonary exacerbation of cystic fibrosis 22.57 9.92 4 123258 8568 29820648
Talipes 22.50 9.92 31 123231 1644 29827572
Pneumonia 22.26 9.92 1629 121633 332677 29496539
Cellulitis 22.19 9.92 292 122970 46492 29782724
Joint effusion 21.53 9.92 47 123215 3616 29825600
Vitamin D deficiency 21.45 9.92 58 123204 5112 29824104
Hand deformity 21.26 9.92 32 123230 1841 29827375
Poor venous access 20.86 9.92 37 123225 2443 29826773
Speech disorder developmental 20.84 9.92 25 123237 1154 29828062
Post procedural infection 20.71 9.92 53 123209 4519 29824697
Hyperglycaemia 20.51 9.92 75 123187 35125 29794091
Haemangioma congenital 20.20 9.92 17 123245 509 29828707
Patent ductus arteriosus 20.17 9.92 42 123220 3127 29826089
Prostate cancer 20.15 9.92 168 123094 23789 29805427
Haematocrit decreased 20.11 9.92 204 123058 30495 29798721
Hyperbilirubinaemia neonatal 19.96 9.92 19 123243 671 29828545
Lacrimal disorder 19.95 9.92 14 123248 318 29828898
Cleft lip 19.91 9.92 14 123248 319 29828897
Lung neoplasm malignant 19.71 9.92 118 123144 15014 29814202
Somnolence 19.65 9.92 280 122982 96483 29732733
Off label use 19.33 9.92 834 122428 248456 29580760
Psychotic disorder 19.27 9.92 37 123225 21478 29807738
Substance abuse 19.17 9.92 3 123259 7037 29822179
Shock 19.03 9.92 41 123221 22818 29806398
Jaundice neonatal 18.97 9.92 23 123239 1074 29828142
Anal fistula 18.88 9.92 47 123215 3939 29825277
Bradycardia neonatal 18.84 9.92 21 123241 895 29828321
Malignant melanoma 18.66 9.92 70 123192 7341 29821875
Congenital bladder anomaly 18.61 9.92 13 123249 293 29828923
Delirium 18.52 9.92 95 123167 40536 29788680
Hallucination 18.46 9.92 122 123140 48937 29780279
Wound 18.31 9.92 100 123162 12302 29816914
Infection 18.15 9.92 435 122827 77639 29751577
Pathogen resistance 18.10 9.92 6 123256 8404 29820812
Septic arthritis staphylococcal 18.03 9.92 15 123247 442 29828774
Hydrocele 17.85 9.92 31 123231 2013 29827203
Sedation 17.60 9.92 25 123237 16348 29812868
Urticaria 17.57 9.92 142 123120 54464 29774752
Weight decrease neonatal 17.48 9.92 13 123249 324 29828892
Contraindicated product administered 17.36 9.92 126 123136 17105 29812111
Constipation 17.29 9.92 344 122918 112562 29716654
Altered state of consciousness 17.20 9.92 35 123227 19884 29809332
Therapeutic product effect decreased 17.07 9.92 189 123073 28887 29800329
Aggression 16.99 9.92 86 123176 36821 29792395
Foetal disorder 16.94 9.92 17 123245 641 29828575
Arthrodesis 16.93 9.92 14 123248 409 29828807
Blood pressure diastolic increased 16.91 9.92 36 123226 2722 29826494
Ankyloglossia congenital 16.89 9.92 12 123250 278 29828938
Electrocardiogram QT prolonged 16.78 9.92 83 123179 35752 29793464
Immunodeficiency 16.65 9.92 47 123215 4247 29824969
Injection site bruising 16.60 9.92 67 123195 7271 29821945
Multiple congenital abnormalities 16.58 9.92 15 123247 496 29828720
Renal aplasia 16.51 9.92 17 123245 661 29828555
Tonsil cancer 16.48 9.92 18 123244 750 29828466
Joint stiffness 16.27 9.92 79 123183 9282 29819934
Crohn's disease 16.26 9.92 47 123215 4305 29824911
Hypermobility syndrome 16.26 9.92 11 123251 235 29828981
Joint range of motion decreased 16.24 9.92 57 123205 5788 29823428
Blood creatine phosphokinase increased 16.02 9.92 110 123152 43738 29785478
Depressed level of consciousness 15.97 9.92 92 123170 38130 29791086
Peripheral artery thrombosis 15.90 9.92 31 123231 2201 29827015
Drug withdrawal syndrome neonatal 15.64 9.92 38 123224 3137 29826079
Congenital anomaly 15.60 9.92 23 123239 1299 29827917
Grip strength decreased 15.30 9.92 30 123232 2138 29827078
Mouth ulceration 15.30 9.92 85 123177 10524 29818692
Oropharyngeal pain 15.28 9.92 182 123080 28314 29800902
Injection site swelling 15.19 9.92 74 123188 8706 29820510
Arthritis infective 15.12 9.92 34 123228 2668 29826548
Blood pressure diastolic decreased 14.99 9.92 58 123204 6173 29823043
Weight decreased 14.78 9.92 761 122501 150160 29679056
No adverse event 14.70 9.92 31 123231 17388 29811828
Neck mass 14.66 9.92 23 123239 1372 29827844
Neuroleptic malignant syndrome 14.61 9.92 28 123234 16267 29812949
Multiple organ dysfunction syndrome 14.60 9.92 179 123083 63308 29765908
Renal impairment 14.59 9.92 251 123011 83933 29745283
Vascular insufficiency 14.56 9.92 12 123250 349 29828867
Product quality issue 14.55 9.92 35 123227 18739 29810477
Maternal exposure timing unspecified 14.47 9.92 12 123250 352 29828864
Hepatocellular injury 14.36 9.92 55 123207 25416 29803800
Rash maculo-papular 14.26 9.92 55 123207 25363 29803853
Hernia pain 14.21 9.92 10 123252 228 29828988
Steatorrhoea 14.20 9.92 16 123246 690 29828526
Autism spectrum disorder 14.14 9.92 22 123240 1303 29827913
Sinusitis 14.13 9.92 204 123058 33141 29796075
Umbilical hernia 14.13 9.92 40 123222 3621 29825595
Blood insulin increased 14.02 9.92 12 123250 368 29828848
Emphysema 14.01 9.92 76 123186 9326 29819890
Otitis media 14.00 9.92 32 123230 2539 29826677
Pyelocaliectasis 13.93 9.92 19 123243 998 29828218
Tuberculosis 13.92 9.92 68 123194 8009 29821207
Hypertriglyceridaemia 13.91 9.92 8 123254 8090 29821126
Kidney infection 13.91 9.92 46 123216 4532 29824684
C-reactive protein decreased 13.87 9.92 24 123238 1554 29827662
Acute hepatic failure 13.79 9.92 17 123245 11810 29817406
Anal atresia 13.79 9.92 11 123251 305 29828911
Back disorder 13.77 9.92 55 123207 5939 29823277
Foot deformity 13.70 9.92 38 123224 3399 29825817
Intellectual disability 13.57 9.92 17 123245 821 29828395
Neonatal seizure 13.47 9.92 13 123249 467 29828749
Dermatitis psoriasiform 13.28 9.92 20 123242 1151 29828065
Agranulocytosis 13.28 9.92 46 123216 21896 29807320
Injection site erythema 13.27 9.92 100 123162 13734 29815482
Lung cancer metastatic 13.25 9.92 31 123231 2497 29826719
Plagiocephaly 13.25 9.92 11 123251 323 29828893
Upper respiratory tract infection 13.24 9.92 172 123090 27304 29801912
Blood pressure diastolic abnormal 13.23 9.92 21 123241 1266 29827950
Developmental delay 13.19 9.92 28 123234 2113 29827103
Palindromic rheumatism 13.15 9.92 9 123253 196 29829020
Hepatic failure 13.14 9.92 84 123178 33959 29795257
Excessive cerumen production 13.02 9.92 10 123252 262 29828954
Status epilepticus 12.82 9.92 16 123246 11056 29818160
Foetal distress syndrome 12.80 9.92 18 123244 973 29828243
Gangrene neonatal 12.80 9.92 9 123253 205 29829011
Foetal heart rate deceleration abnormality 12.79 9.92 12 123250 416 29828800
Pulmonary artery stenosis congenital 12.74 9.92 13 123249 500 29828716
Pleural fibrosis 12.74 9.92 22 123240 1422 29827794
Osteonecrosis of jaw 12.69 9.92 37 123225 18581 29810635
Respiratory rate increased 12.57 9.92 71 123191 8844 29820372
Heart rate decreased 12.57 9.92 137 123125 20857 29808359
Knee deformity 12.56 9.92 11 123251 348 29828868
Diverticular perforation 12.54 9.92 35 123227 3142 29826074
Congenital diaphragmatic hernia 12.36 9.92 9 123253 217 29828999
Lung neoplasm 12.34 9.92 44 123218 4502 29824714
Red blood cell sedimentation rate increased 12.27 9.92 61 123201 7234 29821982
Diabetic ketoacidosis 12.24 9.92 30 123232 15956 29813260
Abnormal behaviour 12.20 9.92 59 123203 25564 29803652
Hypocalcaemia 12.15 9.92 46 123216 21330 29807886
Hepatitis 12.14 9.92 49 123213 22307 29806909
Asthma 12.13 9.92 93 123169 36081 29793135
Hypokalaemia 12.12 9.92 140 123122 50052 29779164
Foetal hypokinesia 12.10 9.92 11 123251 366 29828850
Subdural haematoma 12.01 9.92 39 123223 18933 29810283
Red blood cell count decreased 11.95 9.92 163 123099 26158 29803058
Back pain 11.87 9.92 526 122736 102070 29727146
Haemolysis 11.84 9.92 60 123202 7171 29822045
Disease progression 11.73 9.92 245 123017 79629 29749587
Moaning 11.72 9.92 15 123247 740 29828476
Joint instability 11.66 9.92 11 123251 384 29828832
Pulmonary toxicity 11.66 9.92 43 123219 4473 29824743
Cholestasis 11.56 9.92 58 123204 24892 29804324
Immunosuppression 11.51 9.92 47 123215 5128 29824088
Plasma cell myeloma 11.45 9.92 153 123109 53309 29775907
Congenital hydronephrosis 11.39 9.92 14 123248 663 29828553
Hepatic siderosis 11.39 9.92 8 123254 182 29829034
Injection site haemorrhage 11.37 9.92 63 123199 7792 29821424
Finger deformity 11.33 9.92 17 123245 975 29828241
Pancreatic duct stenosis 11.20 9.92 8 123254 187 29829029
Mean cell volume increased 11.20 9.92 26 123236 2084 29827132
Gangrene 11.14 9.92 43 123219 4571 29824645
Polydactyly 11.14 9.92 19 123243 1216 29828000
Folate deficiency 11.12 9.92 17 123245 992 29828224
Proteinuria 11.07 9.92 32 123230 16113 29813103
Tooth fracture 11.02 9.92 34 123228 3228 29825988
Spina bifida 10.99 9.92 10 123252 333 29828883
Colitis ulcerative 10.98 9.92 99 123163 14335 29814881
Squamous cell carcinoma 10.93 9.92 76 123186 10174 29819042
Cleft palate 10.92 9.92 13 123249 595 29828621
Non-Hodgkin's lymphoma 10.90 9.92 23 123239 1728 29827488
Hypotonia neonatal 10.86 9.92 17 123245 1012 29828204
Skin turgor decreased 10.83 9.92 11 123251 421 29828795
Cerebral haemorrhage 10.81 9.92 85 123177 32802 29796414
Exostosis 10.75 9.92 35 123227 3420 29825796
Venoocclusive liver disease 10.71 9.92 7 123255 6606 29822610
Pulmonary tuberculosis 10.71 9.92 44 123218 4813 29824403
Retinopathy hypertensive 10.71 9.92 9 123253 269 29828947
Pharyngitis 10.66 9.92 56 123206 6786 29822430
Inflammation 10.66 9.92 138 123124 21888 29807328
Lipase increased 10.62 9.92 12 123250 8664 29820552
Vitamin B12 deficiency 10.58 9.92 29 123233 2576 29826640
Incorrect route of product administration 10.54 9.92 19 123243 11296 29817920
Necrotising fasciitis streptococcal 10.53 9.92 7 123255 145 29829071
Neutropenia neonatal 10.44 9.92 12 123250 529 29828687
Placental insufficiency 10.43 9.92 6 123256 95 29829121
Blood albumin decreased 10.43 9.92 88 123174 12504 29816712
Oxygen saturation decreased 10.38 9.92 243 123019 43197 29786019
Pulmonary valve stenosis 10.37 9.92 10 123252 359 29828857
Skin lesion 10.31 9.92 119 123143 18375 29810841
Maternal exposure before pregnancy 10.30 9.92 10 123252 362 29828854
Sexual dysfunction 10.21 9.92 6 123256 5995 29823221
Cardio-respiratory arrest 10.20 9.92 170 123092 57136 29772080
Restlessness 10.20 9.92 53 123209 22546 29806670
Microcephaly 10.20 9.92 13 123249 639 29828577
Duodenal perforation 10.18 9.92 18 123244 1186 29828030
Haemoglobinuria 10.18 9.92 12 123250 544 29828672
Skin graft failure 10.17 9.92 7 123255 154 29829062
Decreased vibratory sense 10.12 9.92 10 123252 370 29828846
Drug-induced liver injury 10.12 9.92 49 123213 21225 29807991
Congenital aortic valve incompetence 10.09 9.92 7 123255 156 29829060
Mesothelioma 10.02 9.92 11 123251 461 29828755
Nose deformity 9.97 9.92 7 123255 159 29829057
Ankylosing spondylitis 9.94 9.92 41 123221 4493 29824723

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Tinea pedis indication 6020002 DOID:12403
Wound indication 13924000
Burn injury indication 48333001
Candidiasis of skin indication 49883006
Pityriasis versicolor indication 56454009 DOID:9060
Hemorrhoids indication 70153002 DOID:9746
Rectal pain indication 77880009
Tinea corporis indication 84849002
Pruritus ani indication 90446007
Diaper rash indication 91487003
Eruption of skin indication 271807003 DOID:0050486
Skin irritation indication 367466007
Tinea cruris indication 399029005
Arthropod bite wound indication 409985002
Itching of skin indication 418363000
Minor Bacterial Skin Infections indication
Paronychia off-label use 71906005 DOID:13117
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Anxiety contraindication 48694002
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Hb SS disease contraindication 127040003 DOID:10923
Benign prostatic hyperplasia contraindication 266569009
Hemochromatosis contraindication 399187006 DOID:2352
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Nervousness contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019034 VUID
N0000147305 NUI
D01170 KEGG_DRUG
4017643 VANDF
4019034 VANDF
4019036 VANDF
C0043491 UMLSCUI
CHEBI:36560 CHEBI
CHEMBL3988900 ChEMBL_ID
D015034 MESH_DESCRIPTOR_UI
SOI2LOH54Z UNII
14806 PUBCHEM_CID
DB09321 DRUGBANK_ID
11423 RXNORM
5049 MMSL
5709 MMSL
001922 NDDF
398971002 SNOMEDCT_US
42841002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 80 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 80 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen HUMAN OTC DRUG LABEL 4 0023-5501 LOTION 10 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 60 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 60 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 120 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.08 g TOPICAL OTC monograph final 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 1 TOPICAL OTC monograph final 8 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0194 PASTE 40 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0323 CREAM 40 g TOPICAL OTC MONOGRAPH FINULLL 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0324 OINTMENT 16 g TOPICAL OTC MONOGRAPH FINULLL 12 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0333 CREAM 16 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0334 CREAM 16 g TOPICAL OTC monograph final 11 sections
Boudreauxs HUMAN OTC DRUG LABEL 1 0132-0557 CREAM 16 g TOPICAL export only 11 sections
Selan Plus Zinc Oxide HUMAN OTC DRUG LABEL 2 0159-2200 CREAM 2 g TOPICAL OTC monograph final 11 sections
CALENDULA DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2189 CREAM 12 g TOPICAL OTC monograph final 8 sections
WHITE MALLOW DIAPER RASH CREAM HUMAN OTC DRUG LABEL 1 0164-2207 CREAM 14 g TOPICAL OTC monograph final 8 sections
ZINC OXIDE HUMAN OTC DRUG LABEL 1 0168-0062 OINTMENT 200 mg TOPICAL OTC monograph final 9 sections
DR SMITHS DIAPER HUMAN OTC DRUG LABEL 1 0178-0330 OINTMENT 100 mg TOPICAL OTC monograph final 12 sections
Dr Smiths Diaper Rash HUMAN OTC DRUG LABEL 1 0178-0340 SPRAY 10 g TOPICAL OTC monograph final 8 sections
Dr Smiths Diaper Rash HUMAN OTC DRUG LABEL 1 0178-0345 SPRAY 10 g TOPICAL OTC monograph final 8 sections
Dr Smiths Diaper Rash HUMAN OTC DRUG LABEL 1 0178-0348 SPRAY 10 g TOPICAL OTC monograph final 8 sections
Dr. Smiths Rash and Skin HUMAN OTC DRUG LABEL 1 0178-0370 OINTMENT 10 g TOPICAL OTC monograph not final 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 25 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 25 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 25 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 25 mg ORAL Unapproved drug other 11 sections
Caladryl HUMAN OTC DRUG LABEL 3 0187-5465 LOTION 78.65 mg TOPICAL OTC monograph final 14 sections
Calcemin Advance HUMAN OTC DRUG LABEL 5 0280-0272 TABLET, FILM COATED 7.50 mg ORAL Export only 2 sections