All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

calcium carbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4239	471-34-1

Description:

Molecule	Description
Synonyms: calcium carbonate carbonic acid calcium salt	Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement. Molecular weight: 100.09 Formula: CCaO3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
3	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 16, 2000	FDA	MCNEIL CONS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1266.98	11.23	328	967398	145345	62375951
Toxicity to various agents	654.03	11.23	1782	965944	245468	62275828
Myocardial infarction	602.48	11.23	3064	964662	96829	62424467
Drug abuse	590.09	11.23	185	967541	72333	62448963
Coronary artery disease	470.58	11.23	1318	966408	31059	62490237
Cerebrovascular accident	433.55	11.23	2977	964749	105047	62416249
Pemphigus	399.85	11.23	4422	963304	179304	62341992
Off label use	382.50	11.23	7619	960107	666843	61854453
Febrile neutropenia	382.40	11.23	767	966959	117682	62403614
Device expulsion	376.24	11.23	45	967681	34877	62486419
Acute myocardial infarction	370.98	11.23	1206	966520	30918	62490378
Systemic lupus erythematosus	361.23	11.23	4814	962912	204104	62317192
Cardiac failure congestive	355.37	11.23	2521	965205	89912	62431384
Glossodynia	320.50	11.23	4149	963577	174727	62346569
Intentional overdose	318.17	11.23	397	967329	73755	62447541
Drug ineffective	307.73	11.23	12921	954805	1031844	61489452
Death	295.04	11.23	3977	963749	370404	62150892
Malignant neoplasm progression	276.09	11.23	519	967207	81602	62439694
Suicide attempt	252.19	11.23	335	967391	60583	62460713
Abdominal discomfort	240.96	11.23	6500	961226	314385	62206911
Gastrointestinal haemorrhage	240.69	11.23	2085	965641	79091	62442205
Hand deformity	212.94	11.23	3515	964211	155942	62365354
Arthropathy	210.88	11.23	4873	962853	229919	62291377
Maternal exposure during pregnancy	208.17	11.23	4601	963125	215461	62305835
Disease progression	197.36	11.23	1081	966645	121677	62399619
Milk-alkali syndrome	188.15	11.23	131	967595	697	62520599
Transient ischaemic attack	187.65	11.23	1099	966627	36654	62484642
Product use in unapproved indication	184.37	11.23	1791	965935	177289	62344007
Wound	183.50	11.23	3502	964224	159761	62361535
Overdose	172.81	11.23	1036	966690	114042	62407254
Drug hypersensitivity	165.98	11.23	3541	964185	307146	62214150
Intentional self-injury	164.89	11.23	93	967633	25594	62495702
Alopecia	151.48	11.23	6439	961287	331097	62190199
Coronary arterial stent insertion	145.42	11.23	197	967529	2632	62518664
Angina unstable	141.89	11.23	326	967400	6769	62514527
Haemoglobin decreased	135.62	11.23	3036	964690	142449	62378847
No adverse event	135.36	11.23	266	967460	41139	62480157
Drug reaction with eosinophilia and systemic symptoms	133.09	11.23	193	967533	33643	62487653
Drug dependence	126.42	11.23	112	967614	24371	62496925
Rheumatoid arthritis	125.75	11.23	4894	962832	248925	62272371
Sopor	121.08	11.23	96	967630	22068	62499228
Pericarditis	120.49	11.23	2739	964987	128840	62392456
Plasma cell myeloma	116.37	11.23	941	966785	34964	62486332
Coronary artery bypass	114.30	11.23	160	967566	2209	62519087
Neutropenia	113.84	11.23	1928	965798	173077	62348219
Discomfort	112.70	11.23	3345	964381	164029	62357267
Angina pectoris	112.41	11.23	815	966911	29263	62492033
Intentional product misuse	110.65	11.23	514	967212	60403	62460893
Drug resistance	107.85	11.23	114	967612	22819	62498477
Anti-cyclic citrullinated peptide antibody positive	106.67	11.23	2420	965306	113792	62407504
Poisoning deliberate	105.96	11.23	21	967705	11197	62510099
Aspirin-exacerbated respiratory disease	104.96	11.23	96	967630	799	62520497
Pyrexia	104.20	11.23	5988	961738	464490	62056806
Drug ineffective for unapproved indication	103.61	11.23	228	967498	33835	62487461
Suicidal ideation	100.64	11.23	549	967177	61872	62459424
Coronary artery occlusion	99.54	11.23	313	967413	7878	62513418
Electrocardiogram QT prolonged	98.52	11.23	519	967207	59011	62462285
Wrong technique in product usage process	97.40	11.23	554	967172	61786	62459510
Respiratory arrest	97.26	11.23	221	967505	32424	62488872
Accidental exposure to product	96.73	11.23	168	967558	27237	62494059
Neoplasm progression	93.54	11.23	266	967460	36162	62485134
Drug withdrawal syndrome	92.13	11.23	171	967555	27023	62494273
Myelosuppression	90.50	11.23	138	967588	23565	62497731
Multiple sclerosis relapse	89.85	11.23	406	967320	48072	62473224
Cytomegalovirus infection	88.98	11.23	113	967613	20839	62500457
Swelling	83.31	11.23	5059	962667	270319	62250977
Device dislocation	83.28	11.23	166	967560	25539	62495757
Synovitis	82.38	11.23	3560	964166	183358	62337938
Somnolence	81.73	11.23	2085	965641	176600	62344696
Serotonin syndrome	81.59	11.23	199	967527	28483	62492813
Respiratory depression	80.62	11.23	55	967671	13660	62507636
Cardio-respiratory arrest	79.20	11.23	561	967165	59398	62461898
Hospitalisation	78.44	11.23	873	966853	84208	62437088
Device difficult to use	76.99	11.23	50	967676	12746	62508550
Urticaria	76.81	11.23	1931	965795	163871	62357425
Poisoning	76.53	11.23	58	967668	13642	62507654
Haematotoxicity	76.10	11.23	24	967702	9352	62511944
Coronary artery stenosis	75.79	11.23	200	967526	4544	62516752
Thrombosis in device	75.47	11.23	151	967575	2839	62518457
Exposure during pregnancy	74.79	11.23	2990	964736	152557	62368739
Sedation	74.36	11.23	321	967405	38488	62482808
Palmar-plantar erythrodysaesthesia syndrome	74.24	11.23	149	967577	22866	62498430
Helicobacter infection	73.00	11.23	1892	965834	90893	62430403
Myocardial ischaemia	72.30	11.23	387	967339	12472	62508824
Atrial fibrillation	71.56	11.23	2305	965421	114331	62406965
Full blood count decreased	71.22	11.23	657	967069	25367	62495929
Coma	69.89	11.23	635	967091	63729	62457567
Fall	69.41	11.23	6911	960815	385423	62135873
Duodenal ulcer	67.94	11.23	266	967460	7490	62513806
Labelled drug-drug interaction medication error	67.84	11.23	392	967334	13007	62508289
Tachycardia	67.30	11.23	1332	966394	116824	62404472
Cholestasis	67.02	11.23	227	967499	29207	62492089
Headache	65.85	11.23	8552	959174	624689	61896607
Unintentional medical device removal	65.57	11.23	8	967718	6107	62515189
Sickle cell anaemia with crisis	63.64	11.23	219	967507	5784	62515512
Anaphylactic shock	63.34	11.23	169	967557	23464	62497832
Neuroleptic malignant syndrome	62.42	11.23	55	967671	12001	62509295
Gastric ulcer	61.87	11.23	599	967127	23438	62497858
Duodenal ulcer perforation	61.69	11.23	1754	965972	85455	62435841
Pain	61.27	11.23	12478	955248	728150	61793146
Vascular stent thrombosis	61.14	11.23	75	967651	902	62520394
Upper gastrointestinal haemorrhage	61.04	11.23	494	967232	18358	62502938
Exposure to toxic agent	60.67	11.23	7	967719	5580	62515716
Hepatocellular injury	59.77	11.23	215	967511	27166	62494130
Acute myeloid leukaemia	58.82	11.23	107	967619	17040	62504256
Metastases to liver	58.23	11.23	176	967550	23463	62497833
Metastases to bone	58.10	11.23	148	967578	20871	62500425
Therapeutic product effect incomplete	58.02	11.23	1456	966270	123600	62397696
Premature delivery	57.36	11.23	710	967016	29571	62491725
Vascular stent stenosis	56.59	11.23	55	967671	498	62520798
Arteriosclerosis coronary artery	55.52	11.23	264	967462	8109	62513187
Post transplant lymphoproliferative disorder	55.40	11.23	6	967720	5025	62516271
Anaphylactic reaction	55.24	11.23	693	967033	65407	62455889
Complication of device insertion	55.22	11.23	23	967703	7541	62513755
Drug use disorder	54.74	11.23	6	967720	4978	62516318
Hepatic failure	54.54	11.23	319	967407	35337	62485959
Lymphocyte count decreased	54.52	11.23	256	967470	30001	62491295
Respiratory disorder	54.42	11.23	360	967366	38722	62482574
Lacunar infarction	54.16	11.23	140	967586	3140	62518156
Nausea	53.80	11.23	11866	955860	842605	61678691
Product quality issue	53.74	11.23	323	967403	35542	62485754
Leukopenia	53.68	11.23	841	966885	76449	62444847
Coronary artery thrombosis	53.58	11.23	76	967650	1063	62520233
Rheumatoid factor positive	53.58	11.23	1675	966051	82731	62438565
Drug interaction	53.55	11.23	2900	964826	226231	62295065
Mucosal inflammation	53.14	11.23	458	967268	46470	62474826
Fatigue	52.64	11.23	14738	952988	873290	61648006
Febrile bone marrow aplasia	52.32	11.23	23	967703	7302	62513994
Device use error	51.93	11.23	12	967714	5749	62515547
Breast cancer stage I	51.84	11.23	20	967706	6869	62514427
Hip arthroplasty	51.74	11.23	1017	966709	46629	62474667
Carotid artery stenosis	51.69	11.23	185	967541	4985	62516311
Infective pulmonary exacerbation of cystic fibrosis	50.98	11.23	36	967690	8781	62512515
Knee arthroplasty	50.71	11.23	1132	966594	53074	62468222
Joint swelling	50.60	11.23	5720	962006	321946	62199350
Deafness transitory	50.34	11.23	100	967626	1870	62519426
Toxic skin eruption	50.18	11.23	74	967652	12811	62508485
Melaena	50.00	11.23	694	967032	29671	62491625
Ascites	50.00	11.23	389	967337	40339	62480957
Asthma	49.70	11.23	1522	966204	126039	62395257
Infusion related reaction	49.66	11.23	4367	963359	241154	62280142
Contusion	49.22	11.23	2777	964949	147267	62374029
Mydriasis	49.21	11.23	66	967660	11890	62509406
Chest pain	48.88	11.23	3874	963852	212085	62309211
Hepatic function abnormal	48.81	11.23	348	967378	36794	62484502
Thrombosis	48.78	11.23	1313	966413	63442	62457854
Haemophagocytic lymphohistiocytosis	48.67	11.23	54	967672	10573	62510723
Anxiety	48.50	11.23	2766	964960	214775	62306521
Recalled product	48.26	11.23	81	967645	1322	62519974
Femur fracture	47.98	11.23	899	966827	40857	62480439
Withdrawal syndrome	47.76	11.23	151	967575	19846	62501450
Temperature regulation disorder	47.50	11.23	17	967709	6115	62515181
Contraindicated product administered	47.27	11.23	3892	963834	213756	62307540
Encephalopathy	46.88	11.23	370	967356	38250	62483046
Device issue	46.60	11.23	195	967531	23586	62497710
Hepatic enzyme increased	46.53	11.23	3634	964092	198694	62322602
Posterior reversible encephalopathy syndrome	46.51	11.23	124	967602	17221	62504075
Insomnia	45.81	11.23	2749	964977	212503	62308793
Neurotoxicity	45.15	11.23	122	967604	16868	62504428
Dystonia	44.97	11.23	89	967637	13730	62507566
Cataract	44.75	11.23	1163	966563	55890	62465406
Therapy partial responder	44.72	11.23	58	967668	10600	62510696
Thrombotic microangiopathy	43.77	11.23	58	967668	10503	62510793
Uterine perforation	43.57	11.23	26	967700	6937	62514359
Agitation	43.28	11.23	645	967081	59112	62462184
Metastases to central nervous system	42.99	11.23	84	967642	13021	62508275
Retroperitoneal haemorrhage	42.75	11.23	116	967610	2681	62518615
Multiple-drug resistance	42.38	11.23	13	967713	5157	62516139
Incorrect route of product administration	42.31	11.23	245	967481	27207	62494089
Seizure	41.82	11.23	1625	966101	131009	62390287
Depressed level of consciousness	41.27	11.23	681	967045	61397	62459899
Irritability	41.14	11.23	298	967428	31396	62489900
Gastric ulcer haemorrhage	41.12	11.23	166	967560	4742	62516554
Flushing	41.09	11.23	852	966874	74235	62447061
Acute graft versus host disease in skin	41.03	11.23	3	967723	3449	62517847
Cytokine release syndrome	40.96	11.23	99	967627	14215	62507081
Coronary artery restenosis	40.82	11.23	39	967687	345	62520951
Acute graft versus host disease	40.36	11.23	9	967717	4419	62516877
Complication of device removal	40.26	11.23	14	967712	5128	62516168
Akathisia	40.23	11.23	48	967678	9098	62512198
Graft versus host disease	39.92	11.23	27	967699	6736	62514560
Gastritis erosive	39.75	11.23	190	967536	5849	62515447
Hypoxia	39.72	11.23	656	967070	59136	62462160
Arteriosclerosis	38.91	11.23	275	967451	9791	62511505
Red blood cell sedimentation rate abnormal	38.84	11.23	467	967259	19315	62501981
Bone marrow failure	38.70	11.23	274	967452	29016	62492280
Vomiting	38.58	11.23	7735	959991	551882	61969414
Graft versus host disease in gastrointestinal tract	38.00	11.23	3	967723	3238	62518058
Shunt stenosis	37.99	11.23	44	967682	496	62520800
Epstein-Barr virus infection	37.87	11.23	40	967686	8010	62513286
Agranulocytosis	37.84	11.23	226	967500	24908	62496388
Body temperature increased	37.78	11.23	373	967353	36819	62484477
Haematocrit decreased	37.57	11.23	824	966902	38516	62482780
Mitral valve incompetence	37.36	11.23	460	967266	19134	62502162
Neutrophil count decreased	37.09	11.23	620	967106	55786	62465510
Paradoxical drug reaction	36.73	11.23	9	967717	4143	62517153
Psoriatic arthropathy	36.55	11.23	1726	966000	89794	62431502
Thrombocytopenia	36.44	11.23	1907	965819	149250	62372046
Multiple organ dysfunction syndrome	36.28	11.23	627	967099	56125	62465171
Device breakage	36.14	11.23	76	967650	11466	62509830
Genital haemorrhage	36.13	11.23	35	967691	7297	62513999
Blood pressure systolic increased	35.97	11.23	962	966764	46435	62474861
Acute generalised exanthematous pustulosis	35.67	11.23	72	967654	11027	62510269
Erythema	35.55	11.23	2255	965471	173496	62347800
Migraine	35.07	11.23	1255	966471	102091	62419205
Cardiac arrest	34.39	11.23	1111	966615	91434	62429862
Muscle spasticity	33.86	11.23	194	967532	21600	62499696
Metastases to lung	33.55	11.23	92	967634	12658	62508638
Exposure via ingestion	33.26	11.23	3	967723	2906	62518390
Carotid artery thrombosis	33.25	11.23	106	967620	2688	62518608
Graft versus host disease in skin	33.20	11.23	3	967723	2902	62518394
Osteoarthritis	32.50	11.23	1771	965955	93572	62427724
Bronchopulmonary aspergillosis	32.27	11.23	51	967675	8584	62512712
Transplant dysfunction	32.20	11.23	17	967709	4855	62516441
Interstitial lung disease	31.97	11.23	709	967017	61199	62460097
Status epilepticus	31.68	11.23	122	967604	15111	62506185
Hyperprolactinaemia	31.62	11.23	10	967716	3890	62517406
Human herpesvirus 6 infection	31.39	11.23	4	967722	2953	62518343
Acute hepatic failure	31.32	11.23	158	967568	18169	62503127
Pathogen resistance	31.00	11.23	31	967695	6367	62514929
Vascular graft	30.96	11.23	50	967676	789	62520507
Food allergy	30.95	11.23	81	967645	11320	62509976
Second primary malignancy	30.65	11.23	46	967680	7907	62513389
Gastrointestinal toxicity	30.59	11.23	44	967682	7697	62513599
Haemorrhage intracranial	30.51	11.23	326	967400	13093	62508203
Faeces discoloured	30.46	11.23	423	967303	18086	62503210
Cardiotoxicity	30.44	11.23	51	967675	8387	62512909
Product preparation error	30.11	11.23	29	967697	6063	62515233
Blood pressure diastolic decreased	29.69	11.23	499	967227	22207	62499089
Acute coronary syndrome	29.42	11.23	259	967467	9867	62511429
Disturbance in social behaviour	29.38	11.23	12	967714	3981	62517315
Shunt occlusion	29.28	11.23	43	967683	622	62520674
Cardiovascular disorder	29.25	11.23	292	967434	11520	62509776
Cytomegalovirus viraemia	28.97	11.23	26	967700	5623	62515673
Ear pain	28.94	11.23	382	967344	35736	62485560
Chronic graft versus host disease	28.90	11.23	6	967720	3096	62518200
Amenorrhoea	28.82	11.23	68	967658	9846	62511450
Systemic infection	28.80	11.23	144	967582	4516	62516780
Ventricular hypertrophy	28.62	11.23	116	967610	3320	62517976
Blood urea increased	28.62	11.23	563	967163	25816	62495480
Heart rate decreased	28.60	11.23	903	966823	44657	62476639
Live birth	28.48	11.23	549	967177	25081	62496215
Disseminated intravascular coagulation	28.31	11.23	172	967554	18879	62502417
Altered state of consciousness	28.22	11.23	247	967479	24983	62496313
Anosognosia	28.14	11.23	7	967719	3189	62518107
Mucormycosis	27.92	11.23	5	967721	2866	62518430
Immune reconstitution inflammatory syndrome	27.77	11.23	31	967695	6053	62515243
Disability assessment scale score increased	27.61	11.23	110	967616	3123	62518173
Hyperhidrosis	27.61	11.23	1352	966374	106484	62414812
Peripheral arterial occlusive disease	27.52	11.23	132	967594	4069	62517227
Adenovirus infection	27.49	11.23	10	967716	3561	62517735
Aspergillus infection	27.31	11.23	51	967675	8042	62513254
Abortion incomplete	27.29	11.23	7	967719	3124	62518172
Aortic valve stenosis	27.18	11.23	111	967615	3188	62518108
Duodenal ulcer haemorrhage	27.03	11.23	91	967635	2376	62518920
Hypocalcaemia	26.80	11.23	653	967073	31060	62490236
Lower gastrointestinal haemorrhage	26.77	11.23	209	967517	7681	62513615
Breast cancer female	26.68	11.23	111	967615	13448	62507848
Tumour lysis syndrome	26.66	11.23	61	967665	8929	62512367
Diverticulum	26.65	11.23	290	967436	11701	62509595
Arthralgia	26.52	11.23	9368	958358	560342	61960954
Inappropriate schedule of product administration	26.51	11.23	1304	966422	102661	62418635
Aplasia	26.51	11.23	16	967710	4243	62517053
Embedded device	26.40	11.23	10	967716	3473	62517823
Pruritus	26.34	11.23	4981	962745	356472	62164824
Brain oedema	26.23	11.23	119	967607	14076	62507220
Neurologic neglect syndrome	26.05	11.23	96	967630	2625	62518671
Pseudomonas infection	25.85	11.23	86	967640	11127	62510169
Eosinophilia	25.80	11.23	222	967504	22534	62498762
Pericardial haemorrhage	25.60	11.23	68	967658	1551	62519745
Hepatitis B reactivation	25.51	11.23	8	967718	3129	62518167
Rhabdomyolysis	25.50	11.23	863	966863	43088	62478208
Extrapyramidal disorder	25.37	11.23	110	967616	13174	62508122
Disturbance in attention	25.36	11.23	419	967307	37770	62483526
Premature labour	25.35	11.23	297	967429	12207	62509089
Spinal stenosis	25.34	11.23	343	967383	14582	62506714
Gastritis	25.20	11.23	746	966980	36557	62484739
Pulmonary toxicity	25.04	11.23	68	967658	9387	62511909
Sexual dysfunction	24.94	11.23	18	967708	4341	62516955
Multiple fractures	24.82	11.23	220	967506	8398	62512898
Pregnancy with contraceptive device	24.81	11.23	21	967705	4673	62516623
Substance abuse	24.80	11.23	22	967704	4785	62516511
Hypercalcaemia	24.79	11.23	586	967140	27736	62493560
Caesarean section	24.78	11.23	381	967345	16651	62504645
Adjustment disorder	24.67	11.23	105	967621	3073	62518223
Device malfunction	24.60	11.23	165	967561	17692	62503604
Nasopharyngitis	24.46	11.23	4318	963408	249939	62271357
Polyneuropathy	24.24	11.23	127	967599	14462	62506834
Skin toxicity	23.82	11.23	22	967704	4692	62516604
Metastases to lymph nodes	23.68	11.23	56	967670	8102	62513194
Sepsis	23.66	11.23	2010	965716	151113	62370183
Juvenile idiopathic arthritis	23.62	11.23	107	967619	3219	62518077
Haematochezia	23.59	11.23	1020	966706	52524	62468772
Bradyphrenia	23.55	11.23	44	967682	6936	62514360
Depression	23.54	11.23	2628	965098	193864	62327432
Blood loss anaemia	23.51	11.23	225	967501	8776	62512520
Hip fracture	23.45	11.23	602	967124	28872	62492424
Hallucination, auditory	23.40	11.23	108	967618	12716	62508580
Mania	23.26	11.23	103	967623	12264	62509032
Stent placement	23.18	11.23	116	967610	3639	62517657
Mood altered	23.03	11.23	131	967595	14612	62506684
Schizoaffective disorder	22.71	11.23	13	967713	3549	62517747
Disease recurrence	22.62	11.23	296	967430	27734	62493562
Haematoma	22.62	11.23	693	967033	34127	62487169
Ischaemic cardiomyopathy	22.55	11.23	86	967640	2391	62518905
Pain in extremity	22.54	11.23	5536	962190	325950	62195346
Lymphopenia	22.51	11.23	175	967551	18152	62503144
Pelvic pain	22.28	11.23	118	967608	13401	62507895
Chronic obstructive pulmonary disease	22.28	11.23	1169	966557	61517	62459779
Breast cancer stage II	22.27	11.23	64	967662	8672	62512624
Drug level increased	22.27	11.23	230	967496	22506	62498790
Infusion site pain	22.19	11.23	158	967568	16711	62504585
Osteonecrosis of jaw	22.14	11.23	389	967337	34734	62486562
Haemorrhage	22.10	11.23	1140	966586	59882	62461414
Mood swings	22.06	11.23	175	967551	18073	62503223
Gastrointestinal pain	21.99	11.23	237	967489	9539	62511757
Electrocardiogram ST segment elevation	21.95	11.23	118	967608	3809	62517487
Hereditary angioedema	21.88	11.23	52	967674	7510	62513786
Vascular pseudoaneurysm	21.84	11.23	62	967664	1472	62519824
Unintended pregnancy	21.69	11.23	38	967688	6141	62515155
Product adhesion issue	21.59	11.23	24	967702	4695	62516601
Device related infection	21.56	11.23	240	967486	23152	62498144
Acute respiratory distress syndrome	21.47	11.23	242	967484	23292	62498004
Blood pressure fluctuation	21.46	11.23	887	966839	45430	62475866
Joint effusion	21.25	11.23	372	967354	16688	62504608
Multiple injuries	21.20	11.23	68	967658	1730	62519566
Joint laxity	21.17	11.23	84	967642	2380	62518916
Diverticulum intestinal haemorrhagic	21.17	11.23	62	967664	1499	62519797
Rash maculo-papular	21.16	11.23	350	967376	31546	62489750
Rectal haemorrhage	21.16	11.23	932	966794	48098	62473198
Cerebral haemorrhage	21.15	11.23	616	967110	30113	62491183
Cystitis haemorrhagic	21.12	11.23	19	967707	4104	62517192
Hemiplegia	20.97	11.23	226	967500	9097	62512199
Colorectal cancer	20.92	11.23	15	967711	3630	62517666
BK virus infection	20.86	11.23	12	967714	3267	62518029
Hemiparesis	20.77	11.23	483	967243	22799	62498497
Blood prolactin increased	20.65	11.23	14	967712	3489	62517807
Metabolic acidosis	20.55	11.23	526	967200	44543	62476753
Haemorrhagic stroke	20.53	11.23	155	967571	5637	62515659
Cell death	20.51	11.23	7	967719	2594	62518702
Abnormal behaviour	20.48	11.23	218	967508	21208	62500088
Hepatic cytolysis	20.42	11.23	144	967582	15263	62506033
Respiratory failure	20.39	11.23	1308	966418	100550	62420746
Pre-eclampsia	20.36	11.23	221	967505	8912	62512384
Osteoporosis	20.32	11.23	1069	966657	56269	62465027
Catatonia	20.23	11.23	23	967703	4454	62516842
Haematemesis	20.22	11.23	607	967119	29805	62491491
Hiatus hernia	20.20	11.23	451	967275	21143	62500153
Cardiac disorder	20.20	11.23	958	966768	49858	62471438
Retroperitoneal haematoma	20.16	11.23	93	967633	2820	62518476
Transplant rejection	20.14	11.23	90	967636	10690	62510606
Dermatitis acneiform	20.14	11.23	28	967698	4968	62516328
Aggression	20.14	11.23	245	967481	23253	62498043
Tooth disorder	20.09	11.23	567	967159	27590	62493706
Rib deformity	20.08	11.23	23	967703	256	62521040
Acute lymphocytic leukaemia recurrent	19.92	11.23	5	967721	2264	62519032
Nephrocalcinosis	19.89	11.23	48	967678	1030	62520266
Psoriasis	19.82	11.23	1561	966165	85396	62435900
Tardive dyskinesia	19.74	11.23	65	967661	8437	62512859
Product dose omission issue	19.55	11.23	3205	964521	231108	62290188
Urinary tract infection	19.53	11.23	4437	963289	260247	62261049
Blood pressure diastolic abnormal	19.53	11.23	321	967405	14221	62507075
Hypertransaminasaemia	19.48	11.23	45	967681	6564	62514732
Peripheral vascular disorder	19.46	11.23	158	967568	5877	62515419
Panic attack	19.45	11.23	232	967494	22099	62499197
Rheumatic fever	19.38	11.23	823	966903	42288	62479008
Dyskinesia	19.36	11.23	357	967369	31645	62489651
Coronary artery aneurysm	19.32	11.23	10	967716	27	62521269
Hepatotoxicity	19.18	11.23	424	967302	36617	62484679
Galactorrhoea	19.15	11.23	21	967705	4134	62517162
Carotid arteriosclerosis	19.08	11.23	48	967678	1058	62520238
Product substitution issue	19.06	11.23	154	967572	15842	62505454
Abnormal loss of weight	18.98	11.23	152	967574	5630	62515666
Oral allergy syndrome	18.92	11.23	12	967714	53	62521243
Pneumonia viral	18.79	11.23	60	967666	7862	62513434
Face oedema	18.77	11.23	207	967519	20005	62501291
Basal cell carcinoma	18.69	11.23	559	967167	27432	62493864
Bradypnoea	18.62	11.23	16	967710	3534	62517762
Musculoskeletal stiffness	18.58	11.23	3143	964583	181475	62339821
Aneurysm	18.55	11.23	89	967637	2744	62518552
Blood pressure increased	18.47	11.23	2778	964948	159284	62362012
Blood calcium increased	18.47	11.23	221	967505	9129	62512167
Injection site haematoma	18.45	11.23	172	967554	6660	62514636
Spinal osteoarthritis	18.42	11.23	348	967378	15838	62505458
Product use issue	18.36	11.23	3718	964008	216802	62304494
Incorrect product administration duration	18.36	11.23	102	967624	11444	62509852
Red blood cell count decreased	18.29	11.23	776	966950	39869	62481427
Bone disorder	18.28	11.23	440	967286	20886	62500410
Wrist fracture	18.28	11.23	300	967426	13287	62508009
Swollen joint count increased	18.23	11.23	697	967029	35357	62485939
Breast cancer stage IV	18.18	11.23	4	967722	1982	62519314
Tremor	18.08	11.23	1752	965974	130487	62390809
Malignant melanoma	18.07	11.23	258	967468	11098	62510198
Eating disorder	18.06	11.23	398	967328	18618	62502678
Accidental death	18.04	11.23	4	967722	1972	62519324
Restlessness	18.00	11.23	328	967398	29125	62492171
Affective disorder	17.99	11.23	42	967684	6104	62515192
Localised infection	17.99	11.23	595	967131	29615	62491681
Oedema peripheral	17.95	11.23	3216	964510	186295	62335001
Miosis	17.93	11.23	55	967671	7298	62513998
Blood pressure systolic abnormal	17.80	11.23	295	967431	13091	62508205
Arthritis	17.76	11.23	2023	965703	113898	62407398
Transaminases increased	17.73	11.23	354	967372	31013	62490283
Aortic arteriosclerosis	17.62	11.23	158	967568	6051	62515245
Rectal polyp	17.57	11.23	50	967676	1189	62520107
Klebsiella infection	17.56	11.23	69	967657	8497	62512799
Sinus node dysfunction	17.53	11.23	127	967599	4558	62516738
Cerebral ischaemia	17.48	11.23	168	967558	6560	62514736
Blood iron abnormal	17.42	11.23	20	967706	3856	62517440
Feeling hot	17.41	11.23	610	967116	49744	62471552
Epilepsy	17.30	11.23	299	967427	26766	62494530
Fracture delayed union	17.27	11.23	78	967648	2344	62518952
Arterial stenosis	17.26	11.23	32	967694	567	62520729
Bradykinesia	17.24	11.23	33	967693	5155	62516141
Dilatation atrial	17.21	11.23	68	967658	1923	62519373
Gamma-glutamyltransferase increased	17.21	11.23	391	967335	33640	62487656
Occult blood positive	17.06	11.23	105	967621	3565	62517731
Aortic stenosis	17.05	11.23	133	967593	4887	62516409
Forced expiratory volume decreased	17.04	11.23	31	967695	4937	62516359
Lung neoplasm	17.02	11.23	152	967574	5814	62515482
Sleep disorder	16.92	11.23	1044	966682	80522	62440774
Product administered to patient of inappropriate age	16.81	11.23	15	967711	3253	62518043
Coeliac disease	16.76	11.23	120	967606	12677	62508619
Diabetic ketoacidosis	16.75	11.23	216	967510	20289	62501007
Aortic valve sclerosis	16.70	11.23	48	967678	1148	62520148
Nicotine dependence	16.67	11.23	35	967691	682	62520614
Rebound effect	16.66	11.23	27	967699	4499	62516797
Device deployment issue	16.62	11.23	21	967705	3881	62517415
Product storage error	16.47	11.23	147	967579	14809	62506487
Cerebral infarction	16.46	11.23	479	967247	23414	62497882
Atrial septal defect	16.45	11.23	170	967556	6768	62514528
Post procedural haematoma	16.45	11.23	50	967676	1235	62520061
Bronchospasm	16.44	11.23	176	967550	17104	62504192
Humerus fracture	16.43	11.23	208	967518	8708	62512588
Vasoplegia syndrome	16.43	11.23	3	967723	1696	62519600
Drug dose omission by device	16.43	11.23	30	967696	4771	62516525
Hyperbilirubinaemia	16.37	11.23	103	967623	11211	62510085
Electrocardiogram ST-T change	16.29	11.23	44	967682	1014	62520282
Coronary angioplasty	16.28	11.23	13	967713	88	62521208
Hyperlipidaemia	16.24	11.23	402	967324	19169	62502127
Maternal drugs affecting foetus	16.24	11.23	136	967590	5106	62516190
Analgesic drug level increased	16.09	11.23	8	967718	2364	62518932
Accidental overdose	16.05	11.23	254	967472	23055	62498241
Shock	16.05	11.23	256	967470	23207	62498089
Aortic aneurysm	16.03	11.23	107	967619	3737	62517559
Laboratory test abnormal	16.01	11.23	530	967196	26382	62494914
Ventricular septal defect	15.99	11.23	118	967608	4260	62517036
Menstruation irregular	15.95	11.23	54	967672	6950	62514346
Metastases to meninges	15.88	11.23	10	967716	2592	62518704
Hypersensitivity myocarditis	15.87	11.23	18	967708	198	62521098
Cerebellar haemorrhage	15.79	11.23	52	967674	1342	62519954
Complication associated with device	15.72	11.23	174	967552	16804	62504492
Vascular dementia	15.72	11.23	30	967696	544	62520752
Nasal obstruction	15.68	11.23	60	967666	1671	62519625
Neck deformity	15.64	11.23	69	967657	2052	62519244
Hypophosphataemic osteomalacia	15.60	11.23	18	967708	202	62521094
Hypertension	15.52	11.23	4625	963101	274678	62246618
Intervertebral disc degeneration	15.49	11.23	331	967395	15401	62505895
Rectourethral fistula	15.43	11.23	9	967717	33	62521263
Implant site pain	15.42	11.23	9	967717	2431	62518865
Urinary retention	15.36	11.23	348	967378	29953	62491343
Coordination abnormal	15.29	11.23	295	967431	13478	62507818
Platelet aggregation increased	15.24	11.23	7	967719	13	62521283
Cerebrovascular disorder	15.21	11.23	82	967644	2650	62518646
Reye's syndrome	15.13	11.23	6	967720	6	62521290
Cross sensitivity reaction	15.11	11.23	7	967719	2155	62519141
Salivary gland calculus	15.11	11.23	16	967710	162	62521134
Hyperthermia	15.04	11.23	80	967646	9076	62512220
Ejection fraction	15.03	11.23	9	967717	2397	62518899
Non-cardiac chest pain	15.03	11.23	154	967572	6118	62515178
Chest discomfort	15.03	11.23	1457	966269	108512	62412784
Nightmare	15.01	11.23	204	967522	18990	62502306
Aspartate aminotransferase increased	15.01	11.23	1178	966548	89099	62432197
Neutropenic colitis	14.99	11.23	15	967711	3080	62518216
Musculoskeletal discomfort	14.89	11.23	369	967357	17598	62503698
Device use issue	14.86	11.23	11	967715	2619	62518677
Oesophagitis haemorrhagic	14.85	11.23	27	967699	471	62520825
Haemorrhagic transformation stroke	14.83	11.23	47	967679	1188	62520108
Sinus arrest	14.83	11.23	64	967662	1885	62519411
Peripheral ischaemia	14.81	11.23	126	967600	4752	62516544
Torsade de pointes	14.80	11.23	131	967595	13220	62508076
Vital capacity decreased	14.80	11.23	4	967722	1724	62519572
Therapy interrupted	14.73	11.23	379	967347	32076	62489220
Oculogyric crisis	14.71	11.23	4	967722	1717	62519579
Premature rupture of membranes	14.66	11.23	128	967598	4865	62516431
Heart rate irregular	14.50	11.23	446	967280	21975	62499321
Middle insomnia	14.49	11.23	123	967603	12520	62508776
Angiopathy	14.46	11.23	120	967606	4493	62516803
Calciphylaxis	14.35	11.23	88	967638	2984	62518312
Diverticulum intestinal	14.30	11.23	161	967565	6552	62514744
Cytomegalovirus infection reactivation	14.25	11.23	24	967702	3939	62517357
Crying	14.25	11.23	260	967466	23083	62498213
Myoclonus	14.15	11.23	164	967562	15704	62505592
Latent tuberculosis	14.05	11.23	78	967648	2549	62518747
Metastasis	14.05	11.23	37	967689	5160	62516136
Muscle rigidity	14.04	11.23	110	967616	11390	62509906
Carotid artery disease	14.00	11.23	56	967670	1593	62519703
Postoperative wound infection	13.88	11.23	239	967487	10686	62510610
Venoocclusive disease	13.87	11.23	7	967719	2051	62519245
Aortic valve incompetence	13.86	11.23	146	967580	5842	62515454
Lichen planopilaris	13.82	11.23	9	967717	42	62521254
Haptoglobin increased	13.82	11.23	9	967717	42	62521254
Weight decreased	13.79	11.23	4564	963162	272234	62249062
Throat clearing	13.73	11.23	73	967653	2346	62518950
Heparin-induced thrombocytopenia	13.73	11.23	118	967608	4464	62516832
Multiple use of single-use product	13.67	11.23	3	967723	1489	62519807
Infusion site erythema	13.66	11.23	113	967613	11566	62509730
Subdural haematoma	13.64	11.23	300	967426	14028	62507268
Twin pregnancy	13.50	11.23	44	967682	1129	62520167
Epstein-Barr virus associated lymphoproliferative disorder	13.44	11.23	6	967720	1888	62519408
Duodenitis	13.37	11.23	101	967625	3674	62517622
Vitello-intestinal duct remnant	13.35	11.23	9	967717	45	62521251
Vascular graft occlusion	13.29	11.23	17	967709	214	62521082
Fluid retention	13.26	11.23	759	966967	58927	62462369
Large intestine polyp	13.25	11.23	186	967540	7971	62513325
Cytopenia	13.23	11.23	113	967613	11488	62509808
Loss of employment	13.19	11.23	9	967717	2235	62519061
Malaise	13.18	11.23	5937	961789	410017	62111279
Increased tendency to bruise	13.11	11.23	230	967496	10322	62510974
Blood cholesterol increased	13.07	11.23	1631	966095	92401	62428895
Varicella zoster virus infection	13.06	11.23	13	967713	2676	62518620
Virologic failure	13.06	11.23	6	967720	1856	62519440
Platelet dysfunction	13.02	11.23	12	967714	101	62521195
Cardiac valve disease	13.00	11.23	110	967616	4142	62517154
Metabolic disorder	12.94	11.23	53	967673	6450	62514846
Crohn's disease	12.92	11.23	123	967603	4790	62516506
Embolic stroke	12.80	11.23	100	967626	3676	62517620
Erythroblast count increased	12.80	11.23	4	967722	0	62521296
Acute lung injury	12.79	11.23	4	967722	1567	62519729
HELLP syndrome	12.78	11.23	40	967686	1004	62520292
Generalised oedema	12.78	11.23	167	967559	15651	62505645
Tenderness	12.76	11.23	442	967284	22136	62499160
Self-injurious ideation	12.75	11.23	13	967713	2646	62518650
Congenital hydronephrosis	12.74	11.23	23	967703	399	62520897
Polycystic ovaries	12.73	11.23	31	967695	4440	62516856
Application site pain	12.71	11.23	28	967698	4154	62517142
Coronary artery reocclusion	12.67	11.23	8	967718	35	62521261
Psychotic symptom	12.66	11.23	4	967722	1557	62519739
Metabolic alkalosis	12.64	11.23	85	967641	2976	62518320
Dyspnoea	12.64	11.23	9582	958144	651731	61869565
Otitis media staphylococcal	12.61	11.23	5	967721	5	62521291
Otitis media bacterial	12.61	11.23	5	967721	5	62521291
Blood creatine phosphokinase MB increased	12.58	11.23	44	967682	1172	62520124
Vascular device infection	12.52	11.23	63	967663	7249	62514047
Shoulder arthroplasty	12.49	11.23	104	967622	3898	62517398
Thrombotic stroke	12.47	11.23	26	967700	504	62520792
Pneumonia fungal	12.47	11.23	42	967684	5413	62515883
Diabetes insipidus	12.40	11.23	13	967713	2612	62518684
Skin cancer	12.35	11.23	245	967481	11250	62510046
Stevens-Johnson syndrome	12.24	11.23	288	967438	24662	62496634
Pharyngeal haemorrhage	12.24	11.23	27	967699	545	62520751
Metastases to peritoneum	12.24	11.23	21	967705	3421	62517875
Device leakage	12.22	11.23	61	967665	7035	62514261
Dysphoria	12.21	11.23	37	967689	4929	62516367
Pelvic haematoma	12.20	11.23	28	967698	581	62520715
Liver function test increased	12.16	11.23	394	967332	32417	62488879
Abdominal pain	12.16	11.23	4148	963578	289308	62231988
Cardiac murmur	12.10	11.23	299	967427	14253	62507043
Psychomotor hyperactivity	12.10	11.23	104	967622	10559	62510737
Septic shock	12.10	11.23	863	966863	65766	62455530
Ileus	12.07	11.23	155	967571	14570	62506726
Eye excision	12.02	11.23	8	967718	39	62521257
Mitral valve calcification	12.00	11.23	38	967688	960	62520336
Vision blurred	11.99	11.23	1222	966504	90702	62430594
Diverticulitis	11.98	11.23	727	966999	38830	62482466
Normal newborn	11.91	11.23	186	967540	8155	62513141
Ischaemia	11.83	11.23	118	967608	4654	62516642
Feeling abnormal	11.80	11.23	2035	965691	146357	62374939
Hepatitis C	11.78	11.23	41	967685	5233	62516063
Tetany	11.78	11.23	61	967665	1940	62519356
Acute myeloid leukaemia recurrent	11.74	11.23	5	967721	1618	62519678
Arterial stent insertion	11.74	11.23	7	967719	27	62521269
Respiration abnormal	11.73	11.23	54	967672	6363	62514933
Infusion site swelling	11.67	11.23	94	967632	9676	62511620
Mitral valve stenosis	11.67	11.23	42	967684	1135	62520161
Peritoneal dialysis complication	11.64	11.23	43	967683	1177	62520119
Hypercalciuria	11.63	11.23	19	967707	303	62520993
Congenital uterine anomaly	11.59	11.23	12	967714	118	62521178
Pain in jaw	11.59	11.23	543	967183	42953	62478343
Body height decreased	11.58	11.23	217	967509	9861	62511435
Glomerular filtration rate increased	11.55	11.23	35	967691	863	62520433
Drug effective for unapproved indication	11.53	11.23	21	967705	3343	62517953
Clear cell renal cell carcinoma	11.48	11.23	49	967677	1436	62519860
Small for dates baby	11.45	11.23	97	967629	3654	62517642
Diverticulitis intestinal haemorrhagic	11.44	11.23	12	967714	120	62521176
Neoplasm recurrence	11.44	11.23	14	967712	2624	62518672
Haemarthrosis	11.44	11.23	85	967641	3076	62518220
Skin plaque	11.40	11.23	77	967649	8243	62513053
Intraventricular haemorrhage	11.38	11.23	63	967663	2057	62519239
COVID-19	11.37	11.23	1530	966196	111573	62409723
Rheumatoid factor increased	11.33	11.23	57	967669	1792	62519504
Catheter site haematoma	11.31	11.23	14	967712	170	62521126
Peritonitis bacterial	11.31	11.23	119	967607	4760	62516536
Alcohol interaction	11.30	11.23	12	967714	2397	62518899
Extraocular muscle disorder	11.29	11.23	12	967714	122	62521174
Metastases to pleura	11.28	11.23	5	967721	1580	62519716
Blood iron increased	11.25	11.23	50	967676	1492	62519804

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	1437.22	12.48	4963	596103	116122	34239743
Drug abuse	1196.29	12.48	148	600918	98948	34256917
Coronary artery disease	1131.10	12.48	2539	598527	45766	34310099
Toxicity to various agents	933.91	12.48	1248	599818	199114	34156751
Completed suicide	780.93	12.48	355	600711	97813	34258052
Off label use	769.84	12.48	4163	596903	415361	33940504
Cardiac failure congestive	680.60	12.48	3037	598029	80233	34275632
Acute myocardial infarction	669.48	12.48	2240	598826	51479	34304386
Drug ineffective	653.73	12.48	4891	596175	451860	33904005
Cerebrovascular accident	422.13	12.48	2699	598367	82112	34273753
Gastrointestinal haemorrhage	419.24	12.48	2781	598285	85696	34270169
Febrile neutropenia	418.68	12.48	1099	599967	135750	34220115
Product use in unapproved indication	394.43	12.48	899	600167	116600	34239265
Gastric haemorrhage	349.73	12.48	631	600435	9630	34346235
Angina unstable	335.71	12.48	667	600399	10986	34344879
Angina pectoris	315.65	12.48	1220	599846	30143	34325722
Death	304.27	12.48	4917	596149	393132	33962733
Coronary arterial stent insertion	284.22	12.48	353	600713	3776	34352089
Coronary artery bypass	276.62	12.48	380	600686	4522	34351343
Chest pain	235.03	12.48	3265	597801	123497	34232368
Thrombosis in device	234.88	12.48	288	600778	3037	34352828
Coronary artery occlusion	216.96	12.48	540	600526	10422	34345443
Disease progression	197.63	12.48	1071	599995	107006	34248859
Drug dependence	176.71	12.48	98	600968	24119	34331746
Intentional product misuse	176.69	12.48	321	600745	45290	34310575
Pyrexia	167.13	12.48	4405	596661	328608	34027257
Myocardial ischaemia	166.88	12.48	667	600399	16741	34339124
Coronary artery stenosis	165.96	12.48	450	600616	9166	34346699
Intentional overdose	162.45	12.48	315	600751	43359	34312506
Malignant neoplasm progression	162.31	12.48	870	600196	87176	34268689
Melaena	159.51	12.48	1099	599967	34281	34321584
Suicide attempt	158.12	12.48	268	600798	38848	34317017
Drug reaction with eosinophilia and systemic symptoms	158.07	12.48	201	600865	32811	34323054
Haemorrhage	157.78	12.48	1461	599605	49909	34305956
Neutropenia	154.40	12.48	1838	599228	154940	34200925
Upper gastrointestinal haemorrhage	151.65	12.48	851	600215	24667	34331198
Overdose	142.88	12.48	947	600119	90112	34265753
Transient ischaemic attack	136.08	12.48	877	600189	26736	34329129
Haemoglobin decreased	135.15	12.48	2868	598198	117904	34237961
Drug resistance	134.68	12.48	148	600918	25779	34330086
Coma	134.06	12.48	374	600692	45304	34310561
Milk-alkali syndrome	129.98	12.48	97	600969	508	34355357
Syncope	121.55	12.48	2229	598837	89222	34266643
Cytomegalovirus infection	121.15	12.48	163	600903	25972	34329893
Dizziness	117.74	12.48	4733	596333	213788	34142077
Atrial fibrillation	117.39	12.48	2844	598222	119549	34236316
Serotonin syndrome	114.76	12.48	104	600962	19829	34336036
Appendicolith	113.71	12.48	9	601057	8592	34347273
Vascular stent thrombosis	107.11	12.48	186	600880	2749	34353116
Multiple organ dysfunction syndrome	106.61	12.48	824	600242	75742	34280123
Labelled drug-drug interaction medication error	106.50	12.48	524	600542	14415	34341450
Gastric ulcer	105.97	12.48	541	600525	15109	34340756
Intentional self-injury	101.52	12.48	55	601011	13716	34342149
Immune reconstitution inflammatory syndrome	101.02	12.48	15	601051	8744	34347121
Somnolence	100.92	12.48	1325	599741	109791	34246074
Poisoning	100.60	12.48	42	601024	12184	34343681
Plasma cell myeloma	100.57	12.48	1136	599930	40901	34314964
Sopor	99.37	12.48	42	601024	12094	34343771
Respiratory depression	96.85	12.48	82	600984	16163	34339702
Psychotic disorder	96.56	12.48	170	600896	24282	34331583
Poisoning deliberate	96.32	12.48	11	601055	7833	34348032
Haematemesis	95.84	12.48	809	600257	26902	34328963
Hepatocellular injury	94.61	12.48	147	600919	22064	34333801
Post transplant lymphoproliferative disorder	91.70	12.48	5	601061	6523	34349342
Pathogen resistance	91.18	12.48	25	601041	9457	34346408
Myelosuppression	90.46	12.48	119	600947	19146	34336719
Treatment failure	89.61	12.48	455	600611	46242	34309623
Product use issue	89.56	12.48	677	600389	62539	34293326
Fall	88.79	12.48	4302	596764	198583	34157282
Neuroleptic malignant syndrome	88.14	12.48	107	600959	17827	34338038
Duodenal ulcer	88.14	12.48	382	600684	9950	34345915
Rheumatoid arthritis	87.28	12.48	1024	600042	37214	34318651
Venoocclusive liver disease	86.63	12.48	16	601050	7950	34347915
Suicidal ideation	85.41	12.48	380	600686	40008	34315857
Respiratory arrest	84.22	12.48	227	600839	27816	34328049
Drug interaction	84.20	12.48	3107	597959	222839	34133026
Septic shock	82.71	12.48	812	600254	71022	34284843
Drug ineffective for unapproved indication	81.44	12.48	179	600887	23536	34332329
Vascular graft	81.41	12.48	115	600951	1407	34354458
Haemorrhage intracranial	80.12	12.48	509	600557	15437	34340428
Ascites	79.89	12.48	471	600595	46100	34309765
Diverticulum	78.23	12.48	286	600780	6873	34348992
Acute graft versus host disease	77.68	12.48	10	601056	6493	34349372
Carotid artery stenosis	76.93	12.48	225	600841	4794	34351071
Hospitalisation	76.58	12.48	618	600448	56284	34299581
Fatigue	76.35	12.48	7379	593687	363274	33992591
Faeces discoloured	76.05	12.48	477	600589	14401	34341464
Neurotoxicity	75.94	12.48	120	600946	17890	34337975
Haematocrit decreased	75.42	12.48	867	600199	31349	34324516
Sepsis	75.08	12.48	2235	598831	164326	34191539
Hepatic function abnormal	73.30	12.48	454	600612	43909	34311956
Mitral valve incompetence	72.63	12.48	473	600593	14470	34341395
Lower gastrointestinal haemorrhage	72.04	12.48	338	600728	9114	34346751
Thrombosis	72.00	12.48	1244	599822	49214	34306651
Sedation	71.76	12.48	159	600907	20847	34335018
Interstitial lung disease	71.40	12.48	747	600319	64535	34291330
Coronary artery thrombosis	71.32	12.48	131	600935	2028	34353837
Arteriosclerosis	71.01	12.48	399	600667	11569	34344296
Coronary artery restenosis	70.52	12.48	88	600978	946	34354919
Mucosal inflammation	70.36	12.48	383	600683	38239	34317626
Substance abuse	70.08	12.48	22	601044	7619	34348246
Akathisia	69.78	12.48	26	601040	8083	34347782
Seizure	69.41	12.48	1327	599739	103530	34252335
Bronchopulmonary aspergillosis	69.39	12.48	90	600976	14569	34341296
Ischaemic cardiomyopathy	68.77	12.48	254	600812	6135	34349730
Aggression	68.47	12.48	391	600675	38573	34317292
Arteriosclerosis coronary artery	68.06	12.48	407	600659	12078	34343787
Vomiting	68.03	12.48	3522	597544	244099	34111766
Posterior reversible encephalopathy syndrome	67.40	12.48	44	601022	9910	34345955
Gastritis erosive	67.38	12.48	240	600826	5692	34350173
Vascular stent stenosis	67.31	12.48	92	600974	1089	34354776
Neoplasm progression	66.71	12.48	193	600873	23107	34332758
Rash maculo-papular	66.17	12.48	258	600808	28193	34327672
Haematuria	66.00	12.48	1219	599847	48847	34307018
Haemophagocytic lymphohistiocytosis	65.25	12.48	76	600990	12897	34342968
Graft versus host disease	64.68	12.48	52	601014	10517	34345348
Gastritis	64.58	12.48	617	600449	21256	34334609
Drug withdrawal syndrome	62.27	12.48	157	600909	19677	34336188
Infective pulmonary exacerbation of cystic fibrosis	61.63	12.48	20	601046	6781	34349084
Cardiac disorder	61.44	12.48	1063	600003	42063	34313802
Incorrect route of product administration	60.63	12.48	101	600965	14744	34341121
Intentional product use issue	60.41	12.48	697	600369	59119	34296746
Mucormycosis	60.35	12.48	14	601052	5928	34349937
Haematotoxicity	60.00	12.48	33	601033	8161	34347704
Acute graft versus host disease in skin	59.77	12.48	9	601057	5192	34350673
Cytokine release syndrome	59.47	12.48	198	600868	22679	34333186
Aspergillus infection	59.29	12.48	74	600992	12180	34343685
Therapy partial responder	59.23	12.48	47	601019	9569	34346296
Hyperlipidaemia	58.91	12.48	440	600626	14089	34341776
Toxic epidermal necrolysis	57.90	12.48	185	600881	21461	34334404
Suspected suicide	57.45	12.48	7	601059	4741	34351124
Gastrooesophageal reflux disease	56.28	12.48	941	600125	36983	34318882
Acute coronary syndrome	55.94	12.48	412	600654	13133	34342732
Cerebral haemorrhage	55.62	12.48	877	600189	34060	34321805
Agranulocytosis	54.77	12.48	217	600849	23604	34332261
Haematochezia	54.55	12.48	1113	599953	45421	34310444
Agitation	54.46	12.48	678	600388	56721	34299144
Cytomegalovirus viraemia	54.30	12.48	30	601036	7400	34348465
Accidental exposure to product	54.26	12.48	85	600981	12717	34343148
Adenovirus infection	54.17	12.48	12	601054	5245	34350620
Occult blood positive	54.13	12.48	173	600893	3875	34351990
Bone marrow failure	53.88	12.48	289	600777	28964	34326901
Leukopenia	52.90	12.48	761	600305	62095	34293770
Rectal haemorrhage	52.70	12.48	979	600087	39270	34316595
Wrong technique in product usage process	50.66	12.48	386	600680	35600	34320265
Multiple-drug resistance	50.02	12.48	14	601052	5225	34350640
Appendicitis	49.83	12.48	113	600953	14694	34341171
Hepatic failure	49.75	12.48	368	600698	34163	34321702
Aspirin-exacerbated respiratory disease	49.59	12.48	46	601020	341	34355524
Subdural haematoma	49.34	12.48	553	600513	19868	34335997
Stomatitis	49.15	12.48	480	600586	42034	34313831
Peripheral vascular disorder	49.09	12.48	194	600872	4842	34351023
Hepatitis B reactivation	48.94	12.48	5	601061	3886	34351979
Status epilepticus	48.63	12.48	89	600977	12525	34343340
Febrile bone marrow aplasia	47.05	12.48	43	601023	8166	34347699
BK virus infection	46.75	12.48	20	601046	5718	34350147
Miosis	46.74	12.48	57	601009	9478	34346387
Dyspnoea	46.55	12.48	7266	593800	369516	33986349
Drug use disorder	46.48	12.48	8	601058	4183	34351682
Cardio-respiratory arrest	46.23	12.48	670	600396	54603	34301262
Tumour lysis syndrome	46.18	12.48	145	600921	16914	34338951
Contusion	46.06	12.48	880	600186	35484	34320381
Thrombocytopenia	46.00	12.48	2206	598860	154041	34201824
Dystonia	45.97	12.48	72	600994	10773	34345092
Cystitis haemorrhagic	45.94	12.48	20	601046	5659	34350206
No adverse event	45.92	12.48	220	600846	22707	34333158
Graft versus host disease in gastrointestinal tract	45.64	12.48	5	601061	3678	34352187
Thrombotic microangiopathy	45.60	12.48	70	600996	10560	34345305
Systemic infection	45.45	12.48	194	600872	5018	34350847
Respiratory failure	45.42	12.48	1471	599595	107101	34248764
Chronic graft versus host disease	45.02	12.48	10	601056	4363	34351502
International normalised ratio increased	44.77	12.48	1098	599968	46229	34309636
Palmar-plantar erythrodysaesthesia syndrome	44.60	12.48	144	600922	16651	34339214
Ventricular hypertrophy	44.53	12.48	177	600889	4430	34351435
Altered state of consciousness	44.51	12.48	222	600844	22671	34333194
Hyperthermia	44.09	12.48	71	600995	10506	34345359
Tricuspid valve incompetence	43.86	12.48	303	600763	9457	34346408
Withdrawal syndrome	43.60	12.48	93	600973	12362	34343503
Cholestasis	42.85	12.48	279	600787	26669	34329196
Pain in extremity	42.61	12.48	2619	598447	123894	34231971
Chronic obstructive pulmonary disease	42.18	12.48	1121	599945	47797	34308068
Depressed level of consciousness	42.17	12.48	502	600564	42339	34313526
Condition aggravated	41.72	12.48	2795	598271	189401	34166464
Shunt stenosis	41.70	12.48	59	601007	723	34355142
Hyperbilirubinaemia	41.60	12.48	149	600917	16694	34339171
Cardiovascular disorder	41.60	12.48	306	600760	9750	34346115
Dyspnoea exertional	41.51	12.48	1006	600060	42273	34313592
Colorectal cancer	41.41	12.48	15	601051	4746	34351119
Neutrophil count decreased	41.17	12.48	624	600442	50480	34305385
Exposure to toxic agent	40.79	12.48	7	601059	3668	34352197
Progressive multifocal leukoencephalopathy	40.28	12.48	66	601000	9698	34346167
Pneumocystis jirovecii pneumonia	40.14	12.48	188	600878	19522	34336343
Pneumonia aspiration	40.10	12.48	494	600572	41409	34314456
Virologic failure	40.04	12.48	6	601060	3474	34352391
Chest discomfort	39.93	12.48	1224	599842	53306	34302559
Diastolic dysfunction	39.90	12.48	212	600854	6015	34349850
Syringe issue	39.78	12.48	24	601042	5640	34350225
Myalgia	39.35	12.48	1796	599270	82314	34273551
Asthenia	39.24	12.48	4803	596263	240448	34115417
Epstein-Barr virus infection	39.11	12.48	44	601022	7584	34348281
Haematoma	38.97	12.48	638	600428	24967	34330898
Irritability	38.56	12.48	257	600809	24433	34331432
Obsessive-compulsive disorder	38.49	12.48	24	601042	5540	34350325
Hyperammonaemia	38.12	12.48	32	601034	6335	34349530
Lymphopenia	38.07	12.48	148	600918	16187	34339678
Rhabdomyolysis	37.64	12.48	1481	599585	66682	34289183
Hiatus hernia	37.15	12.48	242	600824	7403	34348462
Therapeutic product effect incomplete	36.76	12.48	629	600437	49912	34305953
Ventricular extrasystoles	36.57	12.48	341	600725	11667	34344198
Brain oedema	36.35	12.48	119	600947	13702	34342163
Apparent death	36.20	12.48	9	601057	3635	34352230
Disinhibition	36.13	12.48	6	601060	3220	34352645
Dysmorphism	36.11	12.48	128	600938	3028	34352837
Stent placement	36.11	12.48	178	600888	4900	34350965
Multiple injuries	36.08	12.48	92	600974	1803	34354062
Abnormal behaviour	36.01	12.48	266	600800	24703	34331162
Acute myeloid leukaemia	35.61	12.48	177	600889	18093	34337772
Venoocclusive disease	35.25	12.48	4	601062	2863	34353002
Carotid artery disease	34.81	12.48	59	601007	854	34355011
Device leakage	34.73	12.48	37	601029	6538	34349327
Anaemia	34.41	12.48	4547	596519	228788	34127077
Muscle spasms	34.32	12.48	1598	599468	73403	34282462
Gastric ulcer haemorrhage	34.28	12.48	185	600881	5281	34350584
Lacunar infarction	34.23	12.48	124	600942	2966	34352899
Viral mutation identified	34.20	12.48	5	601061	2949	34352916
Cytomegalovirus infection reactivation	34.14	12.48	23	601043	5095	34350770
Vascular pseudoaneurysm	34.03	12.48	98	600968	2069	34353796
Delirium	33.79	12.48	542	600524	43449	34312416
Ventricular dysfunction	33.78	12.48	145	600921	3760	34352105
Polyomavirus-associated nephropathy	33.62	12.48	12	601054	3832	34352033
Hepatitis B	33.51	12.48	32	601034	5951	34349914
Prostate cancer stage I	33.43	12.48	3	601063	2586	34353279
Encephalopathy	33.19	12.48	418	600648	34901	34320964
Peripheral arterial occlusive disease	32.99	12.48	193	600873	5681	34350184
Hepatic encephalopathy	32.98	12.48	135	600931	14550	34341315
Respiratory distress	32.44	12.48	425	600641	35240	34320625
Arterial occlusive disease	32.31	12.48	154	600912	4180	34351685
Subarachnoid haemorrhage	32.29	12.48	346	600720	12289	34343576
Tachycardia	31.86	12.48	1164	599902	83608	34272257
Lipodystrophy acquired	31.81	12.48	9	601057	3335	34352530
Cytomegalovirus chorioretinitis	31.74	12.48	11	601055	3578	34352287
Angiopathy	31.64	12.48	149	600917	4024	34351841
Intermittent claudication	31.55	12.48	99	600967	2195	34353670
Bundle branch block left	31.37	12.48	193	600873	5786	34350079
Osteoarthritis	31.29	12.48	514	600552	20128	34335737
Hyponatraemia	30.94	12.48	1136	599930	81555	34274310
Electrocardiogram abnormal	30.93	12.48	268	600798	8979	34346886
Oedema peripheral	30.35	12.48	2423	598643	117389	34238476
Shunt occlusion	30.28	12.48	54	601012	816	34355049
Left ventricular failure	30.19	12.48	171	600895	4973	34350892
Alcohol abuse	30.07	12.48	22	601044	4668	34351197
Graft versus host disease in skin	29.93	12.48	15	601051	3910	34351955
Lymphocyte count decreased	29.82	12.48	247	600819	22375	34333490
Mydriasis	29.77	12.48	49	601017	7188	34348677
Psychiatric decompensation	29.67	12.48	7	601059	2930	34352935
Aplastic anaemia	29.66	12.48	78	600988	9638	34346227
Peptic ulcer	29.42	12.48	110	600956	2673	34353192
Non-cardiac chest pain	29.40	12.48	149	600917	4148	34351717
Cardiac murmur	29.35	12.48	233	600833	7604	34348261
Fungal infection	29.02	12.48	158	600908	15777	34340088
Helicobacter gastritis	28.92	12.48	65	601001	1171	34354694
Lactic acidosis	28.89	12.48	422	600644	34350	34321515
Full blood count decreased	28.76	12.48	454	600612	17634	34338231
Electrocardiogram QT prolonged	28.71	12.48	513	600553	40439	34315426
Post procedural complication	28.70	12.48	311	600755	11077	34344788
Ejection fraction decreased	28.68	12.48	476	600590	18678	34337187
Post procedural haemorrhage	28.65	12.48	242	600824	8047	34347818
Eye haemorrhage	28.57	12.48	148	600918	4157	34351708
Euphoric mood	28.42	12.48	33	601033	5608	34350257
Diffuse large B-cell lymphoma recurrent	28.37	12.48	10	601056	3218	34352647
Aortic stenosis	28.35	12.48	149	600917	4209	34351656
Duodenal ulcer haemorrhage	28.34	12.48	165	600901	4848	34351017
Acute graft versus host disease in intestine	28.27	12.48	6	601060	2702	34353163
Sickle cell anaemia with crisis	28.06	12.48	141	600925	3912	34351953
Hepatocellular carcinoma	28.05	12.48	54	601012	7455	34348410
Extrapyramidal disorder	27.94	12.48	120	600946	12760	34343105
Iron deficiency anaemia	27.88	12.48	286	600780	10043	34345822
Percutaneous coronary intervention	27.84	12.48	27	601039	213	34355652
Hypercholesterolaemia	27.79	12.48	251	600815	8511	34347354
Ventricular hypokinesia	27.75	12.48	177	600889	5375	34350490
Hallucination, auditory	27.75	12.48	108	600958	11809	34344056
Acute respiratory distress syndrome	27.63	12.48	299	600767	25670	34330195
Drug hypersensitivity	27.56	12.48	1118	599948	79411	34276454
Aplasia	27.54	12.48	23	601043	4565	34351300
Wrong patient received product	27.46	12.48	6	601060	2648	34353217
Ventricular tachycardia	27.37	12.48	624	600442	25955	34329910
Nausea	27.34	12.48	5291	595775	334617	34021248
Injection site pain	27.22	12.48	489	600577	38516	34317349
Retroperitoneal haemorrhage	27.15	12.48	110	600956	2778	34353087
Pseudomonas infection	27.08	12.48	115	600951	12267	34343598
Drug level increased	27.02	12.48	246	600820	21850	34334015
Hyperthermia malignant	26.86	12.48	3	601063	2174	34353691
Sinus node dysfunction	26.77	12.48	144	600922	4105	34351760
Prostate cancer stage IV	26.74	12.48	5	601061	2463	34353402
Unintentional medical device removal	26.71	12.48	7	601059	2729	34353136
Duodenitis	26.70	12.48	158	600908	4670	34351195
Transaminases increased	26.51	12.48	314	600752	26509	34329356
Prescription drug used without a prescription	26.50	12.48	3	601063	2151	34353714
Acute hepatic failure	26.49	12.48	138	600928	13936	34341929
Paranoia	26.45	12.48	112	600954	11956	34343909
Gastrointestinal arteriovenous malformation	26.33	12.48	32	601034	334	34355531
Transplant rejection	26.28	12.48	90	600976	10221	34345644
Aortic aneurysm	26.19	12.48	203	600863	6576	34349289
Cardiomegaly	25.89	12.48	391	600675	15047	34340818
Ecchymosis	25.89	12.48	203	600863	6600	34349265
Speech disorder developmental	25.84	12.48	90	600976	2110	34353755
Adrenal insufficiency	25.74	12.48	139	600927	13908	34341957
Hypokalaemia	25.71	12.48	783	600283	57431	34298434
Blood urea increased	25.65	12.48	694	600372	29670	34326195
Accidental overdose	25.60	12.48	222	600844	19918	34335947
Back disorder	25.60	12.48	199	600867	6452	34349413
Arterial restenosis	25.39	12.48	16	601050	60	34355805
Toxic skin eruption	25.36	12.48	105	600961	11280	34344585
Device use error	25.34	12.48	5	601061	2370	34353495
Retroperitoneal haematoma	25.17	12.48	102	600964	2576	34353289
Nephropathy toxic	25.09	12.48	121	600945	12467	34343398
Haemorrhagic stroke	24.81	12.48	195	600871	6344	34349521
Nocardiosis	24.73	12.48	19	601047	3932	34351933
Benign prostatic hyperplasia	24.65	12.48	368	600698	14127	34341738
Aortic valve incompetence	24.61	12.48	180	600886	5724	34350141
Small intestinal haemorrhage	24.60	12.48	86	600980	2020	34353845
Disseminated intravascular coagulation	24.51	12.48	248	600818	21568	34334297
Mitochondrial toxicity	24.35	12.48	8	601058	2691	34353174
Arthralgia	24.33	12.48	3308	597758	166733	34189132
Tooth disorder	24.19	12.48	290	600776	10592	34345273
Electrocardiogram Q wave abnormal	24.13	12.48	34	601032	415	34355450
Skin toxicity	24.09	12.48	28	601038	4756	34351109
Blood glucose increased	23.91	12.48	1389	599677	65329	34290536
Intraventricular haemorrhage	23.86	12.48	122	600944	3409	34352456
Psychomotor hyperactivity	23.84	12.48	85	600981	9537	34346328
Osteonecrosis of jaw	23.73	12.48	195	600871	17694	34338171
Dilatation atrial	23.68	12.48	83	600983	1952	34353913
Arterial haemorrhage	23.63	12.48	49	601017	833	34355032
Second primary malignancy	23.55	12.48	64	601002	7822	34348043
Acute generalised exanthematous pustulosis	23.38	12.48	51	601015	6725	34349140
Cytopenia	23.26	12.48	126	600940	12597	34343268
Large intestine polyp	23.23	12.48	223	600843	7691	34348174
Carotid bruit	23.13	12.48	22	601044	169	34355696
Arthropathy	23.02	12.48	616	600450	26291	34329574
Oesophageal ulcer	22.97	12.48	117	600949	3264	34352601
Localised infection	22.74	12.48	427	600639	17160	34338705
Cerebrovascular disorder	22.68	12.48	76	600990	1746	34354119
Myoclonus	22.63	12.48	154	600912	14571	34341294
Hepatotoxicity	22.60	12.48	248	600818	21237	34334628
Stenosis	22.54	12.48	66	601000	1407	34354458
Sleep terror	22.50	12.48	6	601060	2312	34353553
Paradoxical drug reaction	22.43	12.48	15	601051	3336	34352529
Sudden cardiac death	22.36	12.48	124	600942	3577	34352288
Aortic valve stenosis	22.34	12.48	99	600967	2604	34353261
Hepatitis C	22.31	12.48	90	600976	9740	34346125
Epilepsy	22.26	12.48	249	600817	21246	34334619
Candida infection	22.20	12.48	196	600870	17519	34338346
Acute kidney injury	22.11	12.48	4772	596294	300216	34055649
Blood phosphorus increased	22.07	12.48	64	601002	7657	34348208
Vitreous haemorrhage	22.00	12.48	90	600976	2283	34353582
Muscular weakness	21.96	12.48	1495	599571	71402	34284463
Gingival bleeding	21.93	12.48	200	600866	6800	34349065
Occult blood	21.84	12.48	47	601019	821	34355044
Page kidney	21.80	12.48	13	601053	43	34355822
Generalised tonic-clonic seizure	21.65	12.48	246	600820	20928	34334937
Mania	21.63	12.48	87	600979	9424	34346441
Myocarditis	21.57	12.48	142	600924	13540	34342325
Spinal epidural haematoma	21.52	12.48	27	601039	292	34355573
Product monitoring error	21.49	12.48	139	600927	4242	34351623
Body height decreased	21.41	12.48	126	600940	3717	34352148
Blood loss anaemia	21.22	12.48	225	600841	7969	34347896
Basal ganglia infarction	21.19	12.48	22	601044	190	34355675
Lymphoma	21.17	12.48	127	600939	12380	34343485
Epistaxis	21.12	12.48	1214	599852	57037	34298828
Drug screen positive	21.04	12.48	22	601044	3921	34351944
Bacteraemia	20.98	12.48	227	600839	19490	34336375
Alcohol interaction	20.94	12.48	12	601054	2901	34352964
Accidental death	20.92	12.48	8	601058	2448	34353417
Stevens-Johnson syndrome	20.89	12.48	212	600854	18427	34337438
Electrocardiogram ST segment depression	20.86	12.48	91	600975	2377	34353488
Gout	20.77	12.48	455	600611	18798	34337067
Chromaturia	20.70	12.48	358	600708	14162	34341703
Catatonia	20.69	12.48	34	601032	4991	34350874
Heart rate irregular	20.52	12.48	384	600682	15423	34340442
Enterocolitis	20.49	12.48	70	600996	7956	34347909
Thrombotic thrombocytopenic purpura	20.42	12.48	113	600953	3257	34352608
Electrocardiogram ST segment elevation	20.32	12.48	157	600909	5081	34350784
Spinal disorder	20.30	12.48	134	600932	4118	34351747
Nocturia	20.10	12.48	266	600800	9944	34345921
Psychotic symptom	20.07	12.48	3	601063	1740	34354125
Nasopharyngitis	20.04	12.48	1429	599637	68539	34287326
Platelet function test abnormal	19.96	12.48	17	601049	111	34355754
Bradypnoea	19.85	12.48	12	601054	2817	34353048
Infusion related reaction	19.81	12.48	729	600337	52328	34303537
Device related infection	19.75	12.48	195	600871	17042	34338823
Wound	19.61	12.48	362	600704	14502	34341363
Blood pressure systolic increased	19.50	12.48	525	600541	22427	34333438
Spinal osteoarthritis	19.45	12.48	210	600856	7473	34348392
Increased tendency to bruise	19.40	12.48	128	600938	3933	34351932
Hand deformity	19.39	12.48	120	600946	3605	34352260
Traumatic intracranial haemorrhage	19.37	12.48	40	601026	678	34355187
Blood creatinine increased	19.28	12.48	1890	599176	93086	34262779
Haemorrhoids	19.24	12.48	355	600711	14220	34341645
Puncture site haemorrhage	19.16	12.48	25	601041	282	34355583
Hungry bone syndrome	19.10	12.48	14	601052	71	34355794
Human herpesvirus 6 infection	19.07	12.48	6	601060	2075	34353790
Antipsychotic drug level below therapeutic	19.03	12.48	10	601056	2537	34353328
Coagulation time abnormal	18.95	12.48	18	601048	138	34355727
Pancytopenia	18.93	12.48	1394	599672	93763	34262102
Extraocular muscle disorder	18.82	12.48	20	601046	178	34355687
Musculoskeletal discomfort	18.82	12.48	217	600849	7851	34348014
Enterococcal infection	18.81	12.48	89	600977	9217	34346648
Peripheral artery aneurysm	18.81	12.48	31	601035	438	34355427
Viral load increased	18.76	12.48	10	601056	2517	34353348
Back pain	18.75	12.48	2380	598686	119409	34236456
Bacterial infection	18.74	12.48	195	600871	16868	34338997
Cardiac aneurysm	18.69	12.48	47	601019	913	34354952
Metabolic acidosis	18.68	12.48	590	600476	43090	34312775
Blood creatine phosphokinase MB increased	18.66	12.48	73	600993	1813	34354052
Heparin-induced thrombocytopenia	18.63	12.48	162	600904	5433	34350432
Acute lymphocytic leukaemia recurrent	18.60	12.48	15	601051	3029	34352836
Systemic candida	18.55	12.48	22	601044	3704	34352161
Coronary angioplasty	18.54	12.48	29	601037	391	34355474
Coronary ostial stenosis	18.52	12.48	14	601052	75	34355790
Hypercalcaemia	18.46	12.48	371	600695	15097	34340768
Cataract	18.42	12.48	585	600481	25601	34330264
Post procedural haematoma	18.42	12.48	63	601003	1463	34354402
Hypoalbuminaemia	18.37	12.48	128	600938	12046	34343819
Hepatic cytolysis	18.33	12.48	160	600906	14336	34341529
Cholelithiasis	18.33	12.48	485	600581	20663	34335202
Product dose omission issue	18.23	12.48	1791	599275	117920	34237945
Hypogammaglobulinaemia	18.11	12.48	70	600996	7670	34348195
Plantar fasciitis	17.87	12.48	78	600988	2038	34353827
Low density lipoprotein increased	17.79	12.48	134	600932	4302	34351563
Atrial flutter	17.75	12.48	371	600695	15203	34340662
Swollen tongue	17.66	12.48	351	600715	14254	34341611
Hallucination	17.60	12.48	715	600351	50783	34305082
Vascular graft occlusion	17.59	12.48	34	601032	548	34355317
Gastrointestinal ulcer	17.56	12.48	67	600999	1644	34354221
Hypertriglyceridaemia	17.54	12.48	80	600986	8368	34347497
Coronary artery insufficiency	17.45	12.48	14	601052	83	34355782
Psoriatic arthropathy	17.44	12.48	455	600611	19343	34336522
Haemorrhage urinary tract	17.32	12.48	71	600995	1803	34354062
Blindness transient	17.26	12.48	80	600986	2146	34353719
Palmoplantar keratoderma	17.25	12.48	6	601060	1947	34353918
Diabetic foot	17.24	12.48	94	600972	2694	34353171
International normalised ratio decreased	17.22	12.48	136	600930	4431	34351434
Helicobacter test positive	17.20	12.48	43	601023	832	34355033
Dermatitis acneiform	17.18	12.48	52	601014	6137	34349728
Ulcer haemorrhage	17.17	12.48	91	600975	2579	34353286
Diffuse large B-cell lymphoma	17.03	12.48	67	600999	7303	34348562
Hypoxia	16.95	12.48	774	600292	54321	34301544
Prostate cancer stage III	16.74	12.48	5	601061	1788	34354077
High density lipoprotein decreased	16.72	12.48	107	600959	3253	34352612
Myocardial rupture	16.70	12.48	18	601048	163	34355702
Eosinophilia	16.67	12.48	334	600732	25888	34329977
Pneumatosis intestinalis	16.67	12.48	26	601040	3897	34351968
Depression	16.60	12.48	1440	599626	95658	34260207
Mallory-Weiss syndrome	16.59	12.48	57	601009	1327	34354538
Nasal polyps	16.57	12.48	86	600980	2417	34353448
Ischaemia	16.52	12.48	135	600931	4445	34351420
Sedation complication	16.51	12.48	5	601061	1772	34354093
Vascular graft complication	16.50	12.48	15	601051	108	34355757
Complications of transplanted kidney	16.48	12.48	34	601032	4575	34351290
Prosthesis implantation	16.45	12.48	8	601058	15	34355850
Therapy non-responder	16.44	12.48	530	600536	38616	34317249
Klebsiella infection	16.43	12.48	83	600983	8448	34347417
Immune effector cell-associated neurotoxicity syndrome	16.36	12.48	24	601042	3689	34352176
Drug-induced liver injury	16.36	12.48	374	600692	28458	34327407
Micturition urgency	16.35	12.48	178	600888	6347	34349518
Renal cyst	16.31	12.48	233	600833	8860	34347005
Blood pressure diastolic decreased	16.30	12.48	233	600833	8861	34347004
Stenotrophomonas infection	16.19	12.48	8	601058	2102	34353763
Cough	16.15	12.48	2875	598191	147265	34208600
Inappropriate schedule of product administration	16.10	12.48	891	600175	61405	34294460
Oesophageal carcinoma	16.00	12.48	94	600972	9210	34346655
Anaphylactic shock	15.99	12.48	186	600880	15755	34340110
Vertebral artery stenosis	15.96	12.48	16	601050	132	34355733
Agonal rhythm	15.92	12.48	12	601054	64	34355801
Asphyxia	15.88	12.48	62	601004	6773	34349092
Fat embolism	15.75	12.48	18	601048	175	34355690
Depression suicidal	15.74	12.48	12	601054	2493	34353372
Erosive duodenitis	15.68	12.48	65	601001	1659	34354206
Encephalitis	15.66	12.48	68	600998	7209	34348656
Hepatitis	15.64	12.48	303	600763	23601	34332264
Hypoaesthesia	15.60	12.48	1243	599823	60201	34295664
Metastases to lung	15.58	12.48	95	600971	9225	34346640
Prostate cancer stage II	15.56	12.48	10	601056	2271	34353594
Retinal artery occlusion	15.55	12.48	69	600997	1816	34354049
Injection site reaction	15.55	12.48	146	600920	12887	34342978
Restlessness	15.48	12.48	327	600739	25155	34330710
Lung disorder	15.48	12.48	466	600600	34230	34321635
Anaemia macrocytic	15.45	12.48	97	600969	2929	34352936
Aortic arteriosclerosis	15.32	12.48	134	600932	4502	34351363
Infection	15.29	12.48	1350	599716	89565	34266300
Granulomatous pneumonitis	15.26	12.48	9	601057	29	34355836
Blood bilirubin increased	15.25	12.48	522	600544	37774	34318091
Foetal anticonvulsant syndrome	15.21	12.48	50	601016	1137	34354728
Silent myocardial infarction	15.17	12.48	26	601040	380	34355485
Chronic kidney disease	15.15	12.48	860	600206	40350	34315515
Reye's syndrome	15.14	12.48	7	601059	11	34355854
Red blood cell count decreased	15.11	12.48	628	600438	28462	34327403
Coronary artery embolism	15.09	12.48	16	601050	142	34355723
Dyspepsia	14.99	12.48	774	600292	35958	34319907
Methaemoglobinaemia	14.96	12.48	24	601042	3557	34352308
Subdural haemorrhage	14.89	12.48	100	600966	3091	34352774
Polyneuropathy	14.86	12.48	174	600892	14722	34341143
Graft thrombosis	14.85	12.48	22	601044	282	34355583
Gallbladder disorder	14.83	12.48	175	600891	6367	34349498
Product substitution issue	14.82	12.48	107	600959	9988	34345877
Ischaemic stroke	14.81	12.48	415	600651	17835	34338030
Pericardial haemorrhage	14.76	12.48	99	600967	3059	34352806
Spinal stenosis	14.75	12.48	147	600919	5122	34350743
Intervertebral disc degeneration	14.70	12.48	172	600894	6245	34349620
JC virus infection	14.63	12.48	10	601056	2198	34353667
Strongyloidiasis	14.61	12.48	15	601051	2696	34353169
Vascular calcification	14.60	12.48	39	601027	787	34355078
Cardiotoxicity	14.60	12.48	49	601017	5599	34350266
Blood prolactin increased	14.55	12.48	6	601060	1754	34354111
Atrioventricular septal defect	14.52	12.48	19	601047	215	34355650
Salivary hypersecretion	14.51	12.48	88	600978	8556	34347309
Hepatojugular reflux	14.50	12.48	32	601034	569	34355296
Pericardial disease	14.48	12.48	27	601039	423	34355442
Osteonecrosis	14.45	12.48	175	600891	14715	34341150
Ulnar nerve injury	14.44	12.48	7	601059	13	34355852
Catheterisation cardiac	14.42	12.48	87	600979	2590	34353275
Hyperpyrexia	14.38	12.48	16	601050	2772	34353093
Leukoencephalopathy	14.32	12.48	32	601034	4183	34351682
Basal cell carcinoma	14.31	12.48	441	600625	19217	34336648
Pneumonia fungal	14.29	12.48	68	600998	7032	34348833
Hypertension	14.27	12.48	2609	598457	133834	34222031
Mitral valve calcification	14.24	12.48	31	601035	546	34355319
Colonic haematoma	14.23	12.48	9	601057	34	34355831
Persecutory delusion	14.22	12.48	14	601052	2566	34353299
Troponin increased	14.21	12.48	275	600791	11114	34344751
Blood homocysteine increased	14.20	12.48	20	601046	244	34355621
Pneumonia cytomegaloviral	14.20	12.48	19	601047	3035	34352830
Arteriovenous malformation	14.19	12.48	38	601028	768	34355097
Stress	14.19	12.48	405	600661	29942	34325923
Foetal exposure during pregnancy	14.18	12.48	796	600270	37305	34318560
Angioedema	14.14	12.48	782	600284	36592	34319273
Vitamin B12 deficiency	14.10	12.48	118	600948	3913	34351952
Terminal state	14.08	12.48	29	601037	3905	34351960
Fungaemia	14.08	12.48	14	601052	2554	34353311
Congenital hiatus hernia	14.07	12.48	39	601027	805	34355060
Multiple sclerosis relapse	14.05	12.48	151	600915	12982	34342883
Intracardiac thrombus	14.01	12.48	82	600984	2414	34353451
Accidental exposure to product by child	13.99	12.48	4	601062	1472	34354393
Clonus	13.95	12.48	16	601050	2734	34353131
Lactose intolerance	13.92	12.48	52	601014	1263	34354602
Dementia	13.92	12.48	322	600744	13426	34342439
Therapeutic product effect variable	13.91	12.48	13	601053	2443	34353422
Inappropriate antidiuretic hormone secretion	13.90	12.48	146	600920	12607	34343258
Middle ear effusion	13.84	12.48	33	601033	619	34355246
Epigastric discomfort	13.83	12.48	75	600991	2145	34353720
Skin flap necrosis	13.81	12.48	7	601059	15	34355850
Product administered to patient of inappropriate age	13.80	12.48	22	601044	3269	34352596
Alopecia	13.80	12.48	316	600750	24039	34331826
Colitis	13.80	12.48	520	600546	37230	34318635
Oculogyric crisis	13.79	12.48	5	601061	1581	34354284
Congenital central nervous system anomaly	13.77	12.48	32	601034	590	34355275
Nasal turbinate hypertrophy	13.75	12.48	13	601053	99	34355766
Mediastinal haematoma	13.75	12.48	13	601053	99	34355766
Platelet aggregation increased	13.74	12.48	8	601058	25	34355840
Liver abscess	13.70	12.48	29	601037	3866	34351999
Gastric ulcer perforation	13.70	12.48	45	601021	1023	34354842
Diverticulum intestinal	13.69	12.48	117	600949	3904	34351961
Left ventricular hypertrophy	13.67	12.48	206	600860	7924	34347941
Pleuritic pain	13.66	12.48	106	600960	3435	34352430
Rotator cuff syndrome	13.65	12.48	153	600913	5496	34350369
Blood urine present	13.65	12.48	262	600804	10572	34345293
Rhinitis perennial	13.64	12.48	22	601044	305	34355560
Muscle haemorrhage	13.63	12.48	110	600956	3608	34352257
Systemic mycosis	13.61	12.48	5	601061	1568	34354297
Cerebral artery occlusion	13.55	12.48	36	601030	724	34355141
Small intestine polyp	13.51	12.48	7	601059	16	34355849
Disturbance in attention	13.50	12.48	341	600725	25604	34330261
Anaemia of malignant disease	13.49	12.48	27	601039	447	34355418
Shunt thrombosis	13.49	12.48	11	601055	67	34355798
Thrombotic stroke	13.46	12.48	20	601046	257	34355608
Haemorrhagic cholecystitis	13.46	12.48	12	601054	84	34355781
Cardiac tamponade	13.36	12.48	144	600922	5122	34350743
Angioplasty	13.35	12.48	43	601023	967	34354898
Fractional exhaled nitric oxide increased	13.35	12.48	45	601021	1037	34354828
Urticaria	13.34	12.48	908	600158	61469	34294396
Venous pressure jugular increased	13.34	12.48	37	601029	764	34355101
Chronic coronary syndrome	13.31	12.48	16	601050	165	34355700
Renal haemorrhage	13.30	12.48	55	601011	1402	34354463
Retinal artery embolism	13.30	12.48	8	601058	27	34355838
Erythema	13.26	12.48	1330	599736	87450	34268415
Bacterial sepsis	13.26	12.48	46	601020	5204	34350661
Neutrophil count increased	13.24	12.48	211	600855	16935	34338930
Arterial stent insertion	13.24	12.48	12	601054	86	34355779
Steroid diabetes	13.18	12.48	11	601055	2184	34353681
Low birth weight baby	13.17	12.48	200	600866	7705	34348160
Skin discolouration	13.17	12.48	401	600665	17444	34338421
Incision site haemorrhage	13.13	12.48	29	601037	516	34355349
Subcapsular renal haematoma	13.10	12.48	25	601041	399	34355466
Angiogram abnormal	13.09	12.48	8	601058	28	34355837
Arterial stenosis	13.09	12.48	47	601019	1119	34354746
Depressive symptom	13.08	12.48	18	601048	2841	34353024
Joint injury	13.02	12.48	226	600840	8947	34346918
Vascular procedure complication	12.96	12.48	7	601059	18	34355847
Hypertransaminasaemia	12.93	12.48	51	601015	5555	34350310
Renal tubular disorder	12.90	12.48	39	601027	4604	34351261
Gangrene	12.86	12.48	128	600938	4458	34351407
Limb discomfort	12.86	12.48	264	600802	10783	34345082
Bundle branch block right	12.85	12.48	191	600875	7325	34348540
Diabetes insipidus	12.83	12.48	19	601047	2909	34352956
Diffuse large B-cell lymphoma refractory	12.82	12.48	3	601063	1263	34354602
Implantable defibrillator insertion	12.81	12.48	36	601030	749	34355116
Blood cholesterol increased	12.69	12.48	452	600614	20091	34335774
Clostridium difficile colitis	12.68	12.48	192	600874	15538	34340327
Gastritis haemorrhagic	12.65	12.48	54	601012	1397	34354468
Physical examination abnormal	12.63	12.48	21	601045	299	34355566
Intervertebral disc protrusion	12.62	12.48	241	600825	9715	34346150
Vascular stent occlusion	12.62	12.48	16	601050	175	34355690
Malignant melanoma in situ	12.59	12.48	61	601005	1667	34354198
Barrett's oesophagus	12.58	12.48	26	601040	441	34355424
Erosive oesophagitis	12.56	12.48	55	601011	1439	34354426
Migraine	12.55	12.48	218	600848	17260	34338605
Drug dose omission by device	12.51	12.48	12	601054	2227	34353638
Neonatal respiratory distress syndrome	12.51	12.48	115	600951	3919	34351946

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myocardial infarction	2238.60	11.34	7050	1213862	177079	78346397
Completed suicide	1813.34	11.34	746	1220166	245021	78278455
Coronary artery disease	1609.17	11.34	3277	1217635	62197	78461279
Drug abuse	1590.00	11.34	285	1220627	162406	78361070
Toxicity to various agents	1350.77	11.34	2765	1218147	418775	78104701
Acute myocardial infarction	1113.68	11.34	3138	1217774	73898	78449578
Cardiac failure congestive	1093.07	11.34	4700	1216212	137702	78385774
Cerebrovascular accident	915.11	11.34	4747	1216165	150545	78372931
Off label use	729.79	11.34	9658	1211254	897557	77625919
Gastrointestinal haemorrhage	653.69	11.34	4185	1216727	143534	78379942
Febrile neutropenia	629.39	11.34	1651	1219261	229348	78294128
Drug ineffective	498.02	11.34	12682	1208230	1068231	77455245
Angina unstable	496.46	11.34	901	1220011	15626	78507850
Coronary arterial stent insertion	447.97	11.34	507	1220405	5537	78517939
Product use in unapproved indication	411.04	11.34	2203	1218709	248156	78275320
Coronary artery bypass	408.21	11.34	484	1220428	5578	78517898
Intentional overdose	362.83	11.34	667	1220245	105293	78418183
Angina pectoris	355.52	11.34	1653	1219259	50079	78473397
Death	333.57	11.34	6389	1214523	560125	77963351
Gastric haemorrhage	325.17	11.34	715	1220197	14335	78509141
Milk-alkali syndrome	320.23	11.34	224	1220688	1196	78522280
Suicide attempt	319.17	11.34	484	1220428	82448	78441028
Transient ischaemic attack	299.84	11.34	1596	1219316	51099	78472377
Malignant neoplasm progression	290.28	11.34	1085	1219827	134905	78388571
Coronary artery occlusion	280.71	11.34	682	1220230	14633	78508843
Drug reaction with eosinophilia and systemic symptoms	264.95	11.34	357	1220555	63887	78459589
Disease progression	253.13	11.34	1716	1219196	182646	78340830
Thrombosis in device	251.65	11.34	361	1220551	5081	78518395
Device expulsion	250.97	11.34	46	1220866	25815	78497661
Haemoglobin decreased	246.49	11.34	4773	1216139	217346	78306130
Overdose	238.97	11.34	1743	1219169	182463	78341013
Intentional product misuse	233.26	11.34	715	1220197	94450	78429026
Drug dependence	233.16	11.34	170	1220742	40599	78482877
Myocardial ischaemia	231.87	11.34	888	1220024	24631	78498845
Chest pain	231.81	11.34	5810	1215102	276494	78246982
Coronary artery stenosis	224.62	11.34	552	1220360	11932	78511544
Upper gastrointestinal haemorrhage	221.05	11.34	1232	1219680	40148	78483328
Neutropenia	220.78	11.34	3088	1217824	284622	78238854
Melaena	214.31	11.34	1632	1219280	59258	78464218
Sopor	211.48	11.34	121	1220791	32889	78490587
Intentional self-injury	206.03	11.34	120	1220792	32299	78491177
Labelled drug-drug interaction medication error	203.00	11.34	901	1220011	26749	78496727
Cytomegalovirus infection	200.27	11.34	214	1220698	42430	78481046
Poisoning deliberate	192.69	11.34	29	1220883	18799	78504677
Drug resistance	192.55	11.34	217	1220695	41996	78481480
Pyrexia	189.17	11.34	8480	1212432	670229	77853247
Respiratory arrest	188.44	11.34	372	1220540	57178	78466298
Coma	174.94	11.34	868	1220044	99781	78423695
Poisoning	173.14	11.34	85	1220827	25187	78498289
Respiratory depression	171.75	11.34	105	1220807	27525	78495951
Atrial fibrillation	166.89	11.34	4088	1216824	193798	78329678
Serotonin syndrome	158.98	11.34	278	1220634	44749	78478727
Fall	157.58	11.34	9046	1211866	478583	78044893
Vascular stent thrombosis	156.94	11.34	236	1220676	3474	78520002
Gastric ulcer	156.88	11.34	972	1219940	32933	78490543
Duodenal ulcer	154.83	11.34	577	1220335	15792	78507684
Somnolence	153.45	11.34	2653	1218259	236328	78287148
Myelosuppression	152.31	11.34	238	1220674	40058	78483418
Aspirin-exacerbated respiratory disease	149.96	11.34	134	1220778	1073	78522403
Drug ineffective for unapproved indication	143.36	11.34	361	1220551	50877	78472599
Haemorrhage	141.70	11.34	2069	1218843	89049	78434427
Neoplasm progression	137.82	11.34	373	1220539	51309	78472167
Rheumatoid arthritis	137.79	11.34	4173	1216739	204297	78319179
Suspected suicide	136.16	11.34	6	1220906	10570	78512906
Carotid artery stenosis	134.62	11.34	365	1220547	8393	78515083
Post transplant lymphoproliferative disorder	134.06	11.34	11	1220901	11453	78512023
Neuroleptic malignant syndrome	129.74	11.34	138	1220774	27421	78496055
Arteriosclerosis coronary artery	129.61	11.34	579	1220333	17237	78506239
Hepatocellular injury	129.56	11.34	340	1220572	47253	78476223
Plasma cell myeloma	128.95	11.34	1315	1219597	51944	78471532
Cardio-respiratory arrest	128.79	11.34	1052	1219860	107458	78416018
Venoocclusive liver disease	125.48	11.34	16	1220896	11755	78511721
Arthropathy	124.57	11.34	3573	1217339	173538	78349938
Haematotoxicity	116.09	11.34	46	1220866	15473	78508003
Multiple organ dysfunction syndrome	113.89	11.34	1233	1219679	119013	78404463
Gastritis erosive	113.35	11.34	395	1220517	10452	78513024
Suicidal ideation	111.06	11.34	698	1220214	75642	78447834
Mitral valve incompetence	111.01	11.34	784	1220128	27781	78495695
Arteriosclerosis	109.14	11.34	560	1220352	17667	78505809
Haemorrhage intracranial	108.96	11.34	731	1220181	25462	78498014
Ascites	108.33	11.34	694	1220218	74868	78448608
Haematemesis	108.29	11.34	1251	1219661	51013	78472463
Sedation	108.12	11.34	418	1220494	51477	78471999
Vascular graft	107.82	11.34	144	1220768	1887	78521589
Coronary artery thrombosis	107.16	11.34	180	1220732	2926	78520550
Acute graft versus host disease	105.57	11.34	15	1220897	10152	78513324
Faeces discoloured	105.47	11.34	786	1220126	28341	78495135
Haemophagocytic lymphohistiocytosis	105.45	11.34	107	1220805	21730	78501746
Immune reconstitution inflammatory syndrome	105.23	11.34	40	1220872	13801	78509675
Pathogen resistance	104.86	11.34	44	1220868	14298	78509178
Pemphigus	104.32	11.34	2122	1218790	97460	78426016
Hepatic function abnormal	102.49	11.34	676	1220236	72431	78451045
Haematocrit decreased	102.45	11.34	1410	1219502	59902	78463574
Posterior reversible encephalopathy syndrome	102.43	11.34	152	1220760	26129	78497347
Drug hypersensitivity	102.33	11.34	3645	1217267	295271	78228205
Bronchopulmonary aspergillosis	102.33	11.34	114	1220798	22180	78501296
Exposure to toxic agent	101.22	11.34	11	1220901	9147	78514329
Appendicolith	97.83	11.34	9	1220903	8542	78514934
Wrong technique in product usage process	97.18	11.34	696	1220216	73179	78450297
Interstitial lung disease	96.73	11.34	1180	1219732	111420	78412056
Maternal exposure during pregnancy	96.67	11.34	2757	1218155	133781	78389695
Drug use disorder	96.62	11.34	10	1220902	8641	78514835
Systemic lupus erythematosus	96.22	11.34	2483	1218429	118666	78404810
Ischaemic cardiomyopathy	95.44	11.34	297	1220615	7398	78516078
Hand deformity	94.00	11.34	2168	1218744	101751	78421725
Thrombosis	93.76	11.34	1809	1219103	82291	78441185
Cholestasis	93.66	11.34	444	1220468	51665	78471811
Vascular stent stenosis	93.19	11.34	116	1220796	1411	78522065
Rhabdomyolysis	93.11	11.34	2151	1218761	100980	78422496
Syncope	92.11	11.34	3488	1217424	175961	78347515
Accidental exposure to product	91.30	11.34	216	1220696	31106	78492370
Coronary artery restenosis	90.96	11.34	107	1220805	1222	78522254
Neurotoxicity	90.28	11.34	230	1220682	32288	78491188
Lower gastrointestinal haemorrhage	90.08	11.34	486	1220426	15639	78507837
Hepatic failure	87.33	11.34	563	1220349	60649	78462827
Graft versus host disease	86.77	11.34	62	1220850	14964	78508512
Agranulocytosis	86.73	11.34	374	1220538	44656	78478820
Mucosal inflammation	85.95	11.34	741	1220171	74839	78448637
Glossodynia	85.91	11.34	2131	1218781	101206	78422270
Wound	85.34	11.34	2357	1218555	113822	78409654
Diverticulum	85.28	11.34	452	1220460	14444	78509032
Acute graft versus host disease in skin	85.15	11.34	9	1220903	7649	78515827
Systemic infection	85.04	11.34	335	1220577	9417	78514059
Haematochezia	84.45	11.34	1845	1219067	85800	78437676
Electrocardiogram QT prolonged	83.91	11.34	931	1219981	89455	78434021
Aspergillus infection	83.62	11.34	102	1220810	19059	78504417
Bone marrow failure	83.02	11.34	451	1220461	50656	78472820
Febrile bone marrow aplasia	83.01	11.34	48	1220864	12972	78510504
Leukopenia	82.47	11.34	1270	1219642	115243	78408233
Infective pulmonary exacerbation of cystic fibrosis	82.47	11.34	47	1220865	12804	78510672
Incorrect route of product administration	82.35	11.34	267	1220645	34662	78488814
Acute myeloid leukaemia	82.27	11.34	223	1220689	30662	78492814
Adenovirus infection	82.02	11.34	15	1220897	8432	78515044
Abdominal discomfort	81.49	11.34	4655	1216257	246072	78277404
Drug withdrawal syndrome	81.42	11.34	266	1220646	34452	78489024
Neutrophil count decreased	80.94	11.34	984	1219928	92975	78430501
Cerebral haemorrhage	80.19	11.34	1285	1219627	56388	78467088
Palmar-plantar erythrodysaesthesia syndrome	79.71	11.34	251	1220661	32883	78490593
Cytomegalovirus viraemia	79.30	11.34	49	1220863	12772	78510704
Acute coronary syndrome	79.21	11.34	575	1220337	20558	78502918
Unintentional medical device removal	78.64	11.34	12	1220900	7700	78515776
Lacunar infarction	78.64	11.34	235	1220677	5722	78517754
Therapy partial responder	77.64	11.34	91	1220821	17306	78506170
Shunt stenosis	77.51	11.34	101	1220811	1290	78522186
Graft versus host disease in gastrointestinal tract	77.47	11.34	5	1220907	6351	78517125
Gastritis	77.07	11.34	1096	1219816	46897	78476579
Cytokine release syndrome	76.90	11.34	287	1220625	35711	78487765
Ventricular hypertrophy	76.30	11.34	257	1220655	6681	78516795
Withdrawal syndrome	76.05	11.34	188	1220724	26666	78496810
Dystonia	75.64	11.34	132	1220780	21267	78502209
Akathisia	74.89	11.34	56	1220856	13203	78510273
Haematuria	74.81	11.34	1475	1219437	67361	78456115
Thrombotic microangiopathy	74.45	11.34	121	1220791	20048	78503428
Substance abuse	74.26	11.34	34	1220878	10492	78512984
Mucormycosis	74.18	11.34	19	1220893	8450	78515026
Hyperlipidaemia	73.91	11.34	666	1220246	25427	78498049
Epstein-Barr virus infection	72.66	11.34	68	1220844	14348	78509128
Lymphocyte count decreased	72.64	11.34	425	1220487	46864	78476612
Gastric ulcer haemorrhage	72.29	11.34	302	1220610	8725	78514751
Status epilepticus	71.95	11.34	174	1220738	24867	78498609
Rectal haemorrhage	71.86	11.34	1601	1219311	74699	78448777
Mydriasis	71.76	11.34	99	1220813	17544	78505932
Depressed level of consciousness	71.67	11.34	1044	1219868	95608	78427868
Exposure during pregnancy	71.27	11.34	2041	1218871	99091	78424385
Seizure	71.04	11.34	2275	1218637	186559	78336917
Sepsis	70.98	11.34	3385	1217527	266043	78257433
Subdural haematoma	70.84	11.34	765	1220147	30669	78492807
Sickle cell anaemia with crisis	70.60	11.34	274	1220638	7648	78515828
Altered state of consciousness	70.47	11.34	388	1220524	43434	78480042
Rash maculo-papular	68.68	11.34	539	1220373	55539	78467937
Contusion	68.00	11.34	2856	1218056	145920	78377556
Tachycardia	68.00	11.34	2137	1218775	175631	78347845
Multiple-drug resistance	67.73	11.34	25	1220887	8783	78514693
Chronic obstructive pulmonary disease	67.31	11.34	1749	1219163	83670	78439806
Breast cancer stage I	67.02	11.34	11	1220901	6689	78516787
Miosis	66.86	11.34	86	1220826	15703	78507773
Cardiovascular disorder	66.73	11.34	489	1220423	17536	78505940
Dizziness	66.68	11.34	9115	1211797	517326	78006150
Encephalopathy	65.86	11.34	686	1220226	66711	78456765
Cardiac disorder	65.84	11.34	1392	1219520	64365	78459111
Colorectal cancer	65.72	11.34	25	1220887	8622	78514854
Septic shock	65.65	11.34	1406	1219506	121395	78402081
Toxic skin eruption	65.57	11.34	153	1220759	22140	78501336
Tumour lysis syndrome	65.16	11.34	171	1220741	23768	78499708
Thrombocytopenia	65.13	11.34	3357	1217555	261902	78261574
Premature delivery	63.95	11.34	594	1220318	22873	78500603
Vomiting	63.85	11.34	9079	1211833	656749	77866727
Occult blood positive	62.92	11.34	240	1220672	6643	78516833
BK virus infection	62.79	11.34	28	1220884	8776	78514700
Agitation	62.63	11.34	1111	1219801	98604	78424872
Retroperitoneal haemorrhage	62.27	11.34	205	1220707	5265	78518211
Chronic graft versus host disease	61.77	11.34	14	1220898	6767	78516709
Haematoma	61.71	11.34	1133	1219779	51062	78472414
Anaphylactic shock	61.63	11.34	312	1220600	35684	78487792
Cystitis haemorrhagic	61.11	11.34	32	1220880	9140	78514336
Joint swelling	60.98	11.34	5172	1215740	283474	78240002
Device difficult to use	60.83	11.34	69	1220843	13316	78510160
Urticaria	60.69	11.34	2270	1218642	182931	78340545
Aplasia	60.46	11.34	22	1220890	7798	78515678
Exposure via ingestion	60.40	11.34	5	1220907	5169	78518307
Device use error	60.18	11.34	17	1220895	7084	78516392
Arthralgia	59.52	11.34	9791	1211121	562012	77961464
Blood pressure systolic increased	59.48	11.34	1394	1219518	65592	78457884
Hepatitis B reactivation	58.98	11.34	11	1220901	6097	78517379
International normalised ratio increased	58.37	11.34	1705	1219207	83016	78440460
Transplant rejection	58.30	11.34	132	1220780	19305	78504171
Multiple injuries	58.13	11.34	150	1220762	3345	78520131
Anti-cyclic citrullinated peptide antibody positive	58.04	11.34	1676	1219236	81467	78442009
Irritability	57.89	11.34	380	1220532	40764	78482712
Hyperthermia	57.83	11.34	118	1220794	17919	78505557
Metastases to liver	57.11	11.34	231	1220681	28083	78495393
Pericarditis	56.34	11.34	2038	1218874	102198	78421278
No adverse event	56.20	11.34	336	1220576	36856	78486620
Multiple sclerosis relapse	56.18	11.34	449	1220463	46084	78477392
Paradoxical drug reaction	55.91	11.34	20	1220892	7165	78516311
Synovitis	55.80	11.34	2833	1218079	147901	78375575
Shunt occlusion	55.71	11.34	90	1220822	1414	78522062
Drug interaction	55.54	11.34	5537	1215375	409646	78113830
Peripheral arterial occlusive disease	55.34	11.34	262	1220650	7996	78515480
Fatigue	54.90	11.34	15495	1205417	914232	77609244
Pain in extremity	54.48	11.34	6377	1214535	358161	78165315
Disseminated intravascular coagulation	54.06	11.34	324	1220588	35518	78487958
Duodenal ulcer haemorrhage	53.78	11.34	235	1220677	6928	78516548
Helicobacter infection	53.69	11.34	1423	1219489	68281	78455195
Second primary malignancy	53.05	11.34	86	1220826	14264	78509212
Hospitalisation	53.00	11.34	1070	1219842	93166	78430310
Peripheral vascular disorder	52.53	11.34	253	1220659	7777	78515699
Brain oedema	51.65	11.34	205	1220707	25058	78498418
Temperature regulation disorder	51.52	11.34	13	1220899	5840	78517636
Acute generalised exanthematous pustulosis	51.08	11.34	118	1220794	17136	78506340
Abnormal behaviour	50.93	11.34	337	1220575	36084	78487392
Flushing	50.61	11.34	999	1219913	87269	78436207
Stent placement	50.55	11.34	216	1220696	6304	78517172
Nausea	50.01	11.34	13468	1207444	943728	77579748
Aggression	49.65	11.34	519	1220393	50439	78473037
Full blood count decreased	49.47	11.34	628	1220284	26191	78497285
Angiopathy	49.16	11.34	227	1220685	6855	78516621
Aortic valve stenosis	48.73	11.34	185	1220727	5109	78518367
Respiratory failure	48.58	11.34	2268	1218644	178643	78344833
Oedema peripheral	48.41	11.34	4489	1216423	247799	78275677
Eosinophilia	48.30	11.34	452	1220460	44893	78478583
Blood urea increased	48.25	11.34	1031	1219881	47759	78475717
Acute hepatic failure	48.21	11.34	267	1220645	29846	78493630
Migraine	47.85	11.34	998	1219914	86495	78436981
Intraventricular haemorrhage	47.67	11.34	174	1220738	4713	78518763
Graft versus host disease in skin	47.10	11.34	17	1220895	6056	78517420
Hiatus hernia	46.95	11.34	555	1220357	22757	78500719
Polyomavirus-associated nephropathy	46.72	11.34	14	1220898	5613	78517863
Osteoarthritis	46.68	11.34	1705	1219207	85604	78437872
Duodenitis	46.47	11.34	243	1220669	7724	78515752
Osteonecrosis of jaw	46.42	11.34	430	1220482	42796	78480680
Lymphopenia	45.68	11.34	277	1220635	30280	78493196
Headache	45.60	11.34	9073	1211839	644699	77878777
Cytomegalovirus infection reactivation	45.26	11.34	40	1220872	8676	78514800
Device issue	45.26	11.34	237	1220675	26871	78496605
Hyperbilirubinaemia	45.18	11.34	207	1220705	24311	78499165
Heart rate decreased	45.18	11.34	1403	1219509	68913	78454563
Pseudomonas infection	45.07	11.34	166	1220746	20737	78502739
Vascular pseudoaneurysm	44.95	11.34	137	1220775	3373	78520103
Venoocclusive disease	44.66	11.34	8	1220904	4565	78518911
Pneumocystis jirovecii pneumonia	44.35	11.34	303	1220609	32205	78491271
Ventricular dysfunction	44.00	11.34	196	1220716	5827	78517649
Hyperprolactinaemia	43.93	11.34	9	1220903	4667	78518809
Hypercalcaemia	43.63	11.34	829	1220083	37601	78485875
Blood loss anaemia	43.60	11.34	395	1220517	15103	78508373
Blood prolactin abnormal	43.40	11.34	3	1220909	3598	78519878
Localised infection	43.15	11.34	812	1220100	36763	78486713
Intercepted product preparation error	42.81	11.34	3	1220909	3557	78519919
Disturbance in attention	42.62	11.34	535	1220377	50266	78473210
Tricuspid valve incompetence	42.25	11.34	475	1220437	19237	78504239
Psychomotor hyperactivity	41.69	11.34	126	1220786	16723	78506753
Femur fracture	41.58	11.34	827	1220085	37825	78485651
Spinal osteoarthritis	41.47	11.34	419	1220493	16508	78506968
Retroperitoneal haematoma	41.47	11.34	176	1220736	5121	78518355
Discomfort	41.30	11.34	2335	1218577	123282	78400194
Acute respiratory distress syndrome	41.25	11.34	453	1220459	43614	78479862
Therapeutic product effect incomplete	40.41	11.34	1764	1219148	139881	78383595
Disturbance in social behaviour	40.12	11.34	13	1220899	4957	78518519
Human herpesvirus 6 infection	40.03	11.34	16	1220896	5354	78518122
Erythema	39.98	11.34	2910	1218002	220380	78303096
Hypoxia	39.97	11.34	1239	1219673	102004	78421472
Complication of device insertion	39.65	11.34	24	1220888	6326	78517150
Gastrooesophageal reflux disease	39.54	11.34	1964	1218948	102282	78421194
Viral mutation identified	39.35	11.34	6	1220906	3852	78519624
Bradyphrenia	39.11	11.34	64	1220848	10576	78512900
Cerebrovascular disorder	38.78	11.34	135	1220777	3570	78519906
Skin toxicity	38.72	11.34	42	1220870	8272	78515204
Metastases to central nervous system	38.72	11.34	125	1220787	16250	78507226
Cytomegalovirus chorioretinitis	38.32	11.34	18	1220894	5472	78518004
Blood pressure diastolic decreased	38.23	11.34	663	1220249	29553	78493923
Hypertension	37.96	11.34	5699	1215213	325293	78198183
Dilatation atrial	37.94	11.34	134	1220778	3570	78519906
Uterine perforation	37.74	11.34	25	1220887	6278	78517198
Diffuse large B-cell lymphoma recurrent	37.70	11.34	9	1220903	4198	78519278
Bradypnoea	37.61	11.34	23	1220889	6029	78517447
Electrocardiogram abnormal	37.56	11.34	407	1220505	16330	78507146
Acute graft versus host disease in intestine	37.51	11.34	8	1220904	4033	78519443
Pneumatosis intestinalis	37.46	11.34	26	1220886	6371	78517105
Aortic stenosis	37.30	11.34	219	1220693	7276	78516200
Blood pressure increased	37.17	11.34	3738	1217174	207622	78315854
Hyperammonaemia	36.92	11.34	71	1220841	11022	78512454
Hallucination, auditory	36.78	11.34	177	1220735	20516	78502960
Myoclonus	36.66	11.34	260	1220652	27400	78496076
Haemorrhagic stroke	36.60	11.34	292	1220620	10754	78512722
Transplant dysfunction	36.47	11.34	34	1220878	7187	78516289
Carotid artery disease	36.46	11.34	96	1220816	2168	78521308
Mania	36.18	11.34	150	1220762	18110	78505366
Aortic valve incompetence	36.12	11.34	260	1220652	9270	78514206
Cardiac murmur	36.07	11.34	386	1220526	15438	78508038
Intermittent claudication	35.92	11.34	126	1220786	3345	78520131
Electrocardiogram ST segment elevation	35.92	11.34	236	1220676	8161	78515315
Anosognosia	35.87	11.34	7	1220905	3757	78519719
Sinus node dysfunction	35.76	11.34	221	1220691	7480	78515996
Catatonia	35.74	11.34	49	1220863	8707	78514769
Metastases to bone	35.69	11.34	223	1220689	24204	78499272
Non-cardiac chest pain	35.61	11.34	259	1220653	9265	78514211
Diastolic dysfunction	35.39	11.34	285	1220627	10526	78512950
Accidental death	35.04	11.34	11	1220901	4280	78519196
Respiratory distress	34.44	11.34	657	1220255	57682	78465794
Angioedema	34.35	11.34	1458	1219454	74577	78448899
Metastases to lung	34.28	11.34	152	1220760	18011	78505465
Extrapyramidal disorder	34.21	11.34	205	1220707	22474	78501002
Dermatitis acneiform	34.10	11.34	63	1220849	9930	78513546
Device dislocation	33.99	11.34	245	1220667	25725	78497751
Device leakage	33.98	11.34	72	1220840	10784	78512692
Post procedural complication	33.90	11.34	533	1220379	23296	78500180
Virologic failure	33.77	11.34	11	1220901	4180	78519296
Haemorrhoids	33.63	11.34	630	1220282	28498	78494978
Spinal stenosis	33.61	11.34	380	1220532	15411	78508065
Transaminases increased	33.61	11.34	573	1220339	51170	78472306
Subarachnoid haemorrhage	33.59	11.34	544	1220368	23921	78499555
Hepatic cytolysis	33.23	11.34	261	1220651	26890	78496586
Heparin-induced thrombocytopenia	33.21	11.34	258	1220654	9424	78514052
Heart rate irregular	33.10	11.34	693	1220219	31986	78491490
Duodenal ulcer perforation	32.99	11.34	1283	1219629	64928	78458548
Adjustment disorder	32.96	11.34	135	1220777	3865	78519611
Nasopharyngitis	32.94	11.34	4403	1216509	249478	78273998
Muscular weakness	32.81	11.34	2873	1218039	157856	78365620
Device related infection	32.71	11.34	351	1220561	33943	78489533
Benign prostatic hyperplasia	32.69	11.34	296	1220616	11316	78512160
Breast cancer stage II	32.59	11.34	46	1220866	8074	78515402
Device breakage	32.42	11.34	72	1220840	10603	78512873
Aortic aneurysm	32.34	11.34	231	1220681	8215	78515261
Hypercholesterolaemia	32.26	11.34	515	1220397	22580	78500896
Acute lymphocytic leukaemia recurrent	32.19	11.34	16	1220896	4708	78518768
Post procedural haemorrhage	32.14	11.34	337	1220575	13407	78510069
Blood creatinine increased	32.02	11.34	2774	1218138	152283	78371193
Aortic arteriosclerosis	31.91	11.34	240	1220672	8678	78514798
Klebsiella infection	31.86	11.34	128	1220784	15592	78507884
Candida infection	31.85	11.34	403	1220509	37811	78485665
Large intestine polyp	31.82	11.34	316	1220596	12392	78511084
Epilepsy	31.82	11.34	437	1220475	40423	78483053
Psychotic disorder	31.82	11.34	444	1220468	40958	78482518
Metastases to lymph nodes	31.68	11.34	70	1220842	10327	78513149
Bundle branch block left	31.66	11.34	292	1220620	11221	78512255
Respiratory disorder	31.36	11.34	490	1220422	44366	78479110
Reye's syndrome	31.34	11.34	13	1220899	16	78523460
Pericardial haemorrhage	31.14	11.34	144	1220768	4351	78519125
Disability assessment scale score increased	31.14	11.34	120	1220792	3338	78520138
Diverticulum intestinal	31.03	11.34	232	1220680	8373	78515103
Hyperthermia malignant	31.01	11.34	4	1220908	2913	78520563
Accidental overdose	30.94	11.34	423	1220489	39158	78484318
Anaemia	30.85	11.34	7470	1213442	437545	78085931
Helicobacter gastritis	30.82	11.34	95	1220817	2354	78521122
Abortion incomplete	30.72	11.34	5	1220907	3059	78520417
Cataract	30.55	11.34	1202	1219710	60918	78462558
Red blood cell sedimentation rate abnormal	30.24	11.34	470	1220442	20493	78502983
Aplastic anaemia	30.19	11.34	156	1220756	17749	78505727
Strongyloidiasis	30.08	11.34	11	1220901	3887	78519589
Ventricular extrasystoles	30.06	11.34	446	1220466	19258	78504218
Cytopenia	29.83	11.34	186	1220726	20197	78503279
Coagulation time abnormal	29.70	11.34	26	1220886	202	78523274
Hypertransaminasaemia	29.62	11.34	89	1220823	11835	78511641
Thrombotic thrombocytopenic purpura	29.62	11.34	183	1220729	6193	78517283
Nocardiosis	29.56	11.34	26	1220886	5653	78517823
Coronary angioplasty	29.52	11.34	34	1220878	379	78523097
Diabetic foot	29.47	11.34	122	1220790	3510	78519966
Electrocardiogram Q wave abnormal	29.44	11.34	42	1220870	588	78522888
Cardiotoxicity	29.24	11.34	93	1220819	12146	78511330
Psychiatric decompensation	29.23	11.34	12	1220900	3951	78519525
Carotid artery thrombosis	29.19	11.34	108	1220804	2945	78520531
Restlessness	29.19	11.34	518	1220394	45974	78477502
Body temperature increased	29.15	11.34	491	1220421	43929	78479547
Anaphylactic reaction	29.09	11.34	1019	1219893	82724	78440752
Prostate cancer stage I	29.01	11.34	3	1220909	2594	78520882
Neurologic neglect syndrome	28.78	11.34	104	1220808	2803	78520673
Appendicitis	28.77	11.34	193	1220719	20601	78502875
Ischaemia	28.72	11.34	217	1220695	7858	78515618
Blood pressure fluctuation	28.66	11.34	1280	1219632	65865	78457611
Face oedema	28.47	11.34	284	1220628	27852	78495624
Psychomotor skills impaired	28.46	11.34	23	1220889	5214	78518262
Deafness transitory	28.31	11.34	53	1220859	942	78522534
Epistaxis	28.26	11.34	2027	1218885	109488	78413988
Blood creatine phosphokinase increased	28.23	11.34	1260	1219652	64830	78458646
Post procedural haematoma	28.23	11.34	92	1220820	2350	78521126
Small intestinal haemorrhage	27.84	11.34	132	1220780	4031	78519445
Hemiparesis	27.83	11.34	695	1220217	33038	78490438
Bacteraemia	27.79	11.34	345	1220567	32479	78490997
Delirium	27.76	11.34	1037	1219875	83590	78439886
Increased tendency to bruise	27.58	11.34	263	1220649	10201	78513275
Drug level increased	27.43	11.34	434	1220478	39217	78484259
Cardiomegaly	27.40	11.34	561	1220351	25791	78497685
Oesophageal carcinoma	27.34	11.34	83	1220829	11001	78512475
Fungal infection	27.22	11.34	462	1220450	41286	78482190
Hypocalcaemia	27.18	11.34	977	1219935	48947	78474529
Oculogyric crisis	27.08	11.34	6	1220906	2946	78520530
Pneumonia aspiration	27.06	11.34	799	1220113	66168	78457308
Alcohol interaction	27.00	11.34	21	1220891	4853	78518623
Complication of device removal	26.76	11.34	13	1220899	3876	78519600
Breast cancer female	26.74	11.34	88	1220824	11373	78512103
Myalgia	26.55	11.34	3239	1217673	182402	78341074
Blood creatine phosphokinase MB increased	26.51	11.34	99	1220813	2712	78520764
Percutaneous coronary intervention	26.46	11.34	32	1220880	377	78523099
Hepatitis B	26.30	11.34	55	1220857	8277	78515199
Pneumonia fungal	26.21	11.34	86	1220826	11124	78512352
Affective disorder	26.18	11.34	55	1220857	8264	78515212
Leukoencephalopathy	26.17	11.34	51	1220861	7878	78515598
Product monitoring error	26.09	11.34	229	1220683	8677	78514799
Polyneuropathy	26.04	11.34	240	1220672	23911	78499565
Food allergy	26.03	11.34	82	1220830	10742	78512734
Bacterial infection	26.02	11.34	330	1220582	30950	78492526
Forced expiratory volume decreased	26.02	11.34	50	1220862	7764	78515712
Subdural haemorrhage	25.95	11.34	168	1220744	5780	78517696
Enterocolitis	25.87	11.34	124	1220788	14388	78509088
Swelling	25.85	11.34	3740	1217172	212971	78310505
Weight decreased	25.59	11.34	5973	1214939	349225	78174251
Extraocular muscle disorder	25.56	11.34	28	1220884	294	78523182
Intervertebral disc degeneration	25.55	11.34	361	1220551	15424	78508052
Ventricular tachycardia	25.44	11.34	831	1220081	41104	78482372
Feeling hot	25.33	11.34	708	1220204	59026	78464450
Anxiety	25.32	11.34	3375	1217537	245137	78278339
Carotid bruit	25.20	11.34	44	1220868	739	78522737
Rheumatoid factor positive	25.16	11.34	1139	1219773	58700	78464776
Systemic candida	24.97	11.34	40	1220872	6666	78516810
Sudden cardiac death	24.93	11.34	151	1220761	5074	78518402
Recalled product	24.92	11.34	49	1220863	905	78522571
Red blood cell count decreased	24.90	11.34	1098	1219814	56415	78467061
Left ventricular failure	24.85	11.34	240	1220672	9341	78514135
Calciphylaxis	24.82	11.34	119	1220793	3651	78519825
Accidental exposure to product by child	24.81	11.34	7	1220905	2919	78520557
Gout	24.79	11.34	524	1220388	24225	78499251
Traumatic intracranial haemorrhage	24.74	11.34	57	1220855	1180	78522296
Metabolic acidosis	24.74	11.34	1022	1219890	81507	78441969
Metabolic disorder	24.58	11.34	66	1220846	9104	78514372
Diverticulum intestinal haemorrhagic	24.55	11.34	124	1220788	3887	78519589
Arterial occlusive disease	24.55	11.34	217	1220695	8239	78515237
Psoriatic arthropathy	24.50	11.34	1444	1219468	76555	78446921
Drug dose omission by device	24.50	11.34	36	1220876	6214	78517262
Renal cancer	24.50	11.34	100	1220812	12126	78511350
Arterial restenosis	24.33	11.34	15	1220897	62	78523414
Gastrointestinal ulcer	24.32	11.34	111	1220801	3335	78520141
Musculoskeletal discomfort	24.30	11.34	433	1220479	19402	78504074
Aortic valve sclerosis	24.24	11.34	71	1220841	1709	78521767
Knee arthroplasty	24.20	11.34	849	1220063	42399	78481077
Behaviour disorder	24.13	11.34	37	1220875	6276	78517200
Prostate cancer stage IV	24.07	11.34	4	1220908	2410	78521066
Helicobacter test positive	23.90	11.34	59	1220853	1279	78522197
Blood prolactin increased	23.89	11.34	16	1220896	3995	78519481
Cell death	23.88	11.34	22	1220890	4677	78518799
Progressive multifocal leukoencephalopathy	23.85	11.34	201	1220711	20399	78503077
Peptic ulcer	23.71	11.34	170	1220742	6053	78517423
Hypoalbuminaemia	23.67	11.34	210	1220702	21087	78502389
Genital haemorrhage	23.58	11.34	37	1220875	6218	78517258
Hepatic enzyme increased	23.55	11.34	3166	1217746	179444	78344032
Mood altered	23.53	11.34	168	1220744	17679	78505797
Hemiplegia	23.52	11.34	340	1220572	14599	78508877
Lipodystrophy acquired	23.50	11.34	19	1220893	4306	78519170
Joint effusion	23.42	11.34	397	1220515	17617	78505859
Hepatocellular carcinoma	23.38	11.34	66	1220846	8955	78514521
Aneurysm	23.36	11.34	112	1220800	3436	78520040
Atrial flutter	23.36	11.34	463	1220449	21162	78502314
Caesarean section	23.32	11.34	294	1220618	12241	78511235
Asthma	23.30	11.34	1766	1219146	133329	78390147
Neutropenic colitis	23.23	11.34	32	1220880	5675	78517801
Cerebral infarction	23.21	11.34	887	1220025	44789	78478687
Ischaemic stroke	23.15	11.34	668	1220244	32463	78491013
Treatment failure	23.11	11.34	2271	1218641	168215	78355261
Blood pressure diastolic abnormal	23.11	11.34	418	1220494	18784	78504692
Product preparation error	23.07	11.34	33	1220879	5760	78517716
Alcohol abuse	22.93	11.34	29	1220883	5334	78518142
Pelvic pain	22.89	11.34	116	1220796	13265	78510211
International normalised ratio decreased	22.86	11.34	206	1220706	7864	78515612
Immune effector cell-associated neurotoxicity syndrome	22.62	11.34	34	1220878	5814	78517662
Live birth	22.54	11.34	408	1220504	18336	78505140
Cholelithiasis	22.48	11.34	1004	1219908	51660	78471816
Clostridium difficile colitis	22.45	11.34	353	1220559	31930	78491546
Blood pressure systolic abnormal	22.39	11.34	380	1220532	16867	78506609
Vascular graft occlusion	22.26	11.34	40	1220872	688	78522788
Mitral valve calcification	22.25	11.34	61	1220851	1412	78522064
Toxic epidermal necrolysis	22.22	11.34	516	1220396	44065	78479411
Hyponatraemia	22.21	11.34	2383	1218529	175465	78348011
Cerebellar haemorrhage	22.07	11.34	96	1220816	2824	78520652
Urinary tract infection	22.06	11.34	4640	1216272	269872	78253604
Product quality issue	21.99	11.34	376	1220536	33564	78489912
Hepatic encephalopathy	21.99	11.34	250	1220662	23916	78499560
Cerebral ischaemia	21.87	11.34	265	1220647	10930	78512546
Psychotic symptom	21.87	11.34	7	1220905	2690	78520786
Gastric cancer	21.84	11.34	81	1220831	10098	78513378
Hepatitis C	21.78	11.34	101	1220811	11824	78511652
Hepatotoxicity	21.68	11.34	609	1220303	50743	78472733
Muscle haemorrhage	21.68	11.34	168	1220744	6132	78517344
Metabolic alkalosis	21.59	11.34	130	1220782	4359	78519117
Ecchymosis	21.58	11.34	340	1220572	14866	78508610
Bradykinesia	21.48	11.34	58	1220854	7985	78515491
Systemic mycosis	21.48	11.34	7	1220905	2659	78520817
Generalised tonic-clonic seizure	21.40	11.34	510	1220402	43400	78480076
Thrombotic stroke	21.37	11.34	40	1220872	711	78522765
Therapy interrupted	21.36	11.34	344	1220568	30997	78492479
Spinal epidural haematoma	21.33	11.34	59	1220853	1373	78522103
Basal cell carcinoma	21.24	11.34	735	1220177	36640	78486836
Arterial stenosis	21.23	11.34	59	1220853	1377	78522099
Cardiac arrest	21.08	11.34	2309	1218603	169787	78353689
Sinus bradycardia	21.07	11.34	521	1220391	24726	78498750
Juvenile idiopathic arthritis	21.07	11.34	135	1220777	4628	78518848
Rectal polyp	21.05	11.34	65	1220847	1612	78521864
Hip arthroplasty	21.03	11.34	706	1220206	35050	78488426
Arthritis	20.95	11.34	2037	1218875	112843	78410633
Coronary artery aneurysm	20.95	11.34	18	1220894	136	78523340
Occult blood	20.91	11.34	66	1220846	1657	78521819
Mediastinal haematoma	20.88	11.34	21	1220891	198	78523278
Acute myeloid leukaemia recurrent	20.83	11.34	13	1220899	3370	78520106
Muscle rigidity	20.82	11.34	199	1220713	19683	78503793
Vitreous haemorrhage	20.80	11.34	112	1220800	3601	78519875
Product administered to patient of inappropriate age	20.79	11.34	33	1220879	5520	78517956
Haemodialysis	20.65	11.34	392	1220520	17776	78505700
Hypogammaglobulinaemia	20.64	11.34	115	1220797	12836	78510640
Hypothermia	20.43	11.34	236	1220676	22510	78500966
Propofol infusion syndrome	20.42	11.34	3	1220909	1980	78521496
Puncture site haemorrhage	20.37	11.34	35	1220877	580	78522896
Sleep terror	20.24	11.34	23	1220889	4435	78519041
Nocturia	20.22	11.34	308	1220604	13373	78510103
Product dose omission issue	20.19	11.34	3406	1217506	244131	78279345
Amenorrhoea	20.14	11.34	56	1220856	7636	78515840
Paranoia	20.14	11.34	195	1220717	19237	78504239
Sinus arrest	20.12	11.34	109	1220803	3513	78519963
Pneumonia cytomegaloviral	20.09	11.34	28	1220884	4941	78518535
Chronic kidney disease	20.08	11.34	1221	1219691	64933	78458543
Splenic rupture	20.03	11.34	82	1220830	2347	78521129
Malignant melanoma	19.95	11.34	327	1220585	14414	78509062
Rotator cuff syndrome	19.94	11.34	315	1220597	13780	78509696
Inappropriate antidiuretic hormone secretion	19.93	11.34	283	1220629	26030	78497446
Stevens-Johnson syndrome	19.89	11.34	452	1220460	38714	78484762
Epstein-Barr virus associated lymphoproliferative disorder	19.84	11.34	15	1220897	3517	78519959
Gastrointestinal toxicity	19.81	11.34	61	1220851	8048	78515428
Pulmonary calcification	19.77	11.34	29	1220883	417	78523059
Wrong patient received product	19.71	11.34	25	1220887	4593	78518883
Catheter site haematoma	19.71	11.34	27	1220885	363	78523113
Page kidney	19.70	11.34	13	1220899	62	78523414
Aortic valve disease	19.69	11.34	70	1220842	1871	78521605
Eye haemorrhage	19.52	11.34	232	1220680	9525	78513951
Erosive duodenitis	19.50	11.34	74	1220838	2043	78521433
Dermatitis exfoliative generalised	19.50	11.34	52	1220860	7189	78516287
Drug effective for unapproved indication	19.46	11.34	39	1220873	5962	78517514
Blood calcium increased	19.38	11.34	244	1220668	10156	78513320
Tendonitis	19.37	11.34	490	1220422	23340	78500136
Coronary artery insufficiency	19.31	11.34	19	1220893	174	78523302
Embolic stroke	19.31	11.34	194	1220718	7632	78515844
Basal ganglia infarction	19.27	11.34	34	1220878	576	78522900
Oesophagitis haemorrhagic	19.23	11.34	36	1220876	640	78522836
Joint laxity	19.22	11.34	79	1220833	2265	78521211
Pain	19.19	11.34	11422	1209490	692380	77831096
Ventricular hypokinesia	19.17	11.34	222	1220690	9057	78514419
Mitochondrial toxicity	19.12	11.34	12	1220900	3102	78520374
Pancreatic carcinoma stage IV	19.12	11.34	5	1220907	2193	78521283
Pre-eclampsia	19.07	11.34	178	1220734	6863	78516613
Hip fracture	19.03	11.34	611	1220301	30150	78493326
Abortion spontaneous	19.01	11.34	589	1220323	28918	78494558
Depressive symptom	18.95	11.34	44	1220868	6379	78517097
Dyspnoea exertional	18.95	11.34	1564	1219348	85509	78437967
Encephalitis	18.95	11.34	140	1220772	14620	78508856
Pruritus	18.88	11.34	5572	1215340	389076	78134400
Blood homocysteine increased	18.82	11.34	28	1220884	408	78523068
Diabetes insipidus	18.79	11.34	32	1220880	5205	78518271
Cardiac tamponade	18.75	11.34	221	1220691	9055	78514421
Oesophageal ulcer	18.73	11.34	176	1220736	6799	78516677
Syringe issue	18.70	11.34	43	1220869	6255	78517221
Sputum increased	18.65	11.34	26	1220886	4587	78518889
Rebound effect	18.63	11.34	53	1220859	7173	78516303
Low density lipoprotein increased	18.58	11.34	208	1220704	8414	78515062
Hypokalaemia	18.52	11.34	1926	1218986	142114	78381362
Shock	18.50	11.34	516	1220396	43032	78480444
Arterial haemorrhage	18.45	11.34	83	1220829	2478	78520998
Troponin increased	18.43	11.34	405	1220507	18850	78504626
Extradural haematoma	18.37	11.34	90	1220822	2786	78520690
Silent myocardial infarction	18.33	11.34	37	1220875	697	78522779
Cardiac aneurysm	18.28	11.34	58	1220854	1460	78522016
Myopathy	18.27	11.34	428	1220484	20135	78503341
Myocardial rupture	18.24	11.34	21	1220891	234	78523242
Wrong technique in device usage process	18.05	11.34	21	1220891	4007	78519469
Mallory-Weiss syndrome	18.04	11.34	89	1220823	2763	78520713
Pericardial rub	18.04	11.34	8	1220904	13	78523463
Enterococcal infection	18.04	11.34	153	1220759	15507	78507969
Nicotine dependence	18.01	11.34	43	1220869	912	78522564
Breast cancer stage IV	18.00	11.34	4	1220908	1960	78521516
Proteinuria	17.98	11.34	370	1220542	32132	78491344
Varicella zoster virus infection	17.98	11.34	25	1220887	4416	78519060
Psoriasis	17.91	11.34	1599	1219313	87988	78435488
Dyskinesia	17.89	11.34	535	1220377	44238	78479238
Skin flap necrosis	17.87	11.34	10	1220902	33	78523443
Electrocardiogram ST segment depression	17.86	11.34	132	1220780	4746	78518730
Vascular graft complication	17.85	11.34	17	1220895	149	78523327
Asthenia	17.84	11.34	8367	1212545	503322	78020154
Cardiac stress test abnormal	17.83	11.34	39	1220873	779	78522697
Platelet aggregation increased	17.69	11.34	15	1220897	111	78523365
Renal haemorrhage	17.69	11.34	75	1220837	2181	78521295
Naevus flammeus	17.69	11.34	13	1220899	76	78523400
Pneumomediastinum	17.67	11.34	18	1220894	3649	78519827
Corneal oedema	17.66	11.34	9	1220903	2611	78520865
High density lipoprotein decreased	17.64	11.34	127	1220785	4528	78518948
Gastrointestinal arteriovenous malformation	17.62	11.34	43	1220869	925	78522551
Otitis media staphylococcal	17.62	11.34	7	1220905	7	78523469
Acute graft versus host disease in liver	17.62	11.34	4	1220908	1931	78521545
Persecutory delusion	17.61	11.34	30	1220882	4879	78518597
Type V hyperlipidaemia	17.59	11.34	45	1220867	998	78522478
Paronychia	17.50	11.34	61	1220851	7747	78515729
Fungaemia	17.46	11.34	27	1220885	4564	78518912
Vertebral artery stenosis	17.40	11.34	18	1220894	176	78523300
Coronary artery surgery	17.32	11.34	18	1220894	177	78523299
Cerebral arteriosclerosis	17.30	11.34	38	1220874	761	78522715
Normal newborn	17.30	11.34	175	1220737	6897	78516579
Hypertensive heart disease	17.26	11.34	117	1220795	4089	78519387
Fracture delayed union	17.22	11.34	71	1220841	2039	78521437
Intracranial aneurysm	17.17	11.34	124	1220788	4426	78519050
Chromaturia	17.15	11.34	516	1220396	25230	78498246
Supraventricular extrasystoles	17.14	11.34	173	1220739	6814	78516662
Steroid diabetes	17.13	11.34	17	1220895	3489	78519987
Platelet dysfunction	17.13	11.34	27	1220885	415	78523061
Anion gap	17.09	11.34	6	1220906	2175	78521301
Peripheral swelling	17.04	11.34	4508	1216404	265109	78258367
Osteoporosis	17.04	11.34	1002	1219910	53110	78470366
Platelet function test abnormal	17.02	11.34	18	1220894	181	78523295
Cross sensitivity reaction	17.02	11.34	19	1220893	3693	78519783
Right ventricular failure	17.00	11.34	255	1220657	23242	78500234
Swollen tongue	16.97	11.34	806	1220106	41764	78481712
Carotid arteriosclerosis	16.89	11.34	83	1220829	2573	78520903
Gastrointestinal angiodysplasia	16.88	11.34	45	1220867	1024	78522452
Coronary ostial stenosis	16.85	11.34	17	1220895	161	78523315
Injection site pain	16.84	11.34	1735	1219177	128103	78395373
Impaired healing	16.83	11.34	1560	1219352	86095	78437381
Myelodysplastic syndrome	16.75	11.34	345	1220567	29956	78493520
Diffuse large B-cell lymphoma	16.69	11.34	113	1220799	12036	78511440
Hungry bone syndrome	16.65	11.34	18	1220894	186	78523290
Enthesopathy	16.65	11.34	260	1220652	11348	78512128
Hepatojugular reflux	16.58	11.34	33	1220879	615	78522861
Generalised oedema	16.57	11.34	259	1220653	23450	78500026
Peripheral sensory neuropathy	16.55	11.34	124	1220788	12909	78510567
Vascular device infection	16.51	11.34	91	1220821	10185	78513291
Mitral valve prolapse	16.49	11.34	70	1220842	2037	78521439
Device malfunction	16.48	11.34	230	1220682	21218	78502258
Systolic dysfunction	16.44	11.34	107	1220805	3688	78519788
Mood swings	16.44	11.34	210	1220702	19670	78503806
Galactorrhoea	16.35	11.34	19	1220893	3627	78519849
Torsade de pointes	16.34	11.34	203	1220709	19109	78504367
Embedded device	16.33	11.34	16	1220896	3303	78520173
Rib deformity	16.28	11.34	19	1220893	215	78523261
Polyarthritis	16.26	11.34	270	1220642	11932	78511544
Calcification metastatic	16.24	11.34	15	1220897	126	78523350
Arterial stent insertion	16.22	11.34	13	1220899	88	78523388
Depression	16.21	11.34	2997	1217915	213793	78309683
Left ventricular hypertrophy	16.18	11.34	251	1220661	10940	78512536
Polycythaemia vera	16.12	11.34	24	1220888	350	78523126
Meningitis cryptococcal	16.01	11.34	18	1220894	3488	78519988
Prostate cancer stage II	16.00	11.34	7	1220905	2219	78521257
Haemorrhagic cholecystitis	16	11.34	13	1220899	90	78523386
Cardiac valve disease	15.99	11.34	146	1220766	5595	78517881
Rash morbilliform	15.94	11.34	45	1220867	6105	78517371
Musculoskeletal stiffness	15.88	11.34	2976	1217936	172032	78351444
Tenderness	15.79	11.34	474	1220438	23168	78500308
Renal cyst	15.77	11.34	315	1220597	14417	78509059
Coronary artery reocclusion	15.74	11.34	16	1220896	153	78523323
Insomnia	15.71	11.34	3416	1217496	241754	78281722
Blindness transient	15.69	11.34	126	1220786	4650	78518826
Terminal state	15.66	11.34	32	1220880	4857	78518619
Obsessive-compulsive disorder	15.63	11.34	43	1220869	5884	78517592
Atrioventricular block	15.63	11.34	302	1220610	13739	78509737
Haemorrhagic transformation stroke	15.62	11.34	82	1220830	2610	78520866
Prostate cancer stage III	15.62	11.34	4	1220908	1779	78521697
Viral haemorrhagic cystitis	15.60	11.34	6	1220906	2055	78521421
Coordination abnormal	15.59	11.34	361	1220551	16951	78506525
Drug abuser	15.58	11.34	44	1220868	5969	78517507
Vanishing bile duct syndrome	15.55	11.34	4	1220908	1774	78521702
Erosive oesophagitis	15.52	11.34	86	1220826	2796	78520680
Bicytopenia	15.45	11.34	30	1220882	4640	78518836
Congenital hiatus hernia	15.43	11.34	37	1220875	787	78522689
Choroidal dystrophy	15.42	11.34	10	1220902	46	78523430
Graft thrombosis	15.42	11.34	26	1220886	424	78523052
Premature rupture of membranes	15.41	11.34	111	1220801	3958	78519518
Pregnancy with contraceptive device	15.37	11.34	20	1220892	3634	78519842
Adrenal insufficiency	15.26	11.34	326	1220586	28161	78495315
Skin ulcer	15.25	11.34	993	1219919	53157	78470319
Anaemia postoperative	15.24	11.34	63	1220849	1811	78521665
Urinary bladder haemorrhage	15.24	11.34	78	1220834	2458	78521018
Dementia Alzheimer's type	15.20	11.34	42	1220870	977	78522499
Blood glucose decreased	15.18	11.34	517	1220395	25717	78497759
Liver abscess	15.17	11.34	45	1220867	6009	78517467
Peripheral artery aneurysm	15.17	11.34	26	1220886	430	78523046
Abdominal wall haematoma	15.17	11.34	127	1220785	4746	78518730
Diverticulitis intestinal haemorrhagic	15.16	11.34	27	1220885	461	78523015
Mental disorder	15.13	11.34	364	1220548	30938	78492538
Coronary artery perforation	15.12	11.34	12	1220900	80	78523396
Otitis media bacterial	15.10	11.34	6	1220906	6	78523470
Tetany	15.09	11.34	82	1220830	2646	78520830
Eye excision	15.00	11.34	12	1220900	81	78523395
Renal tubular disorder	15.00	11.34	50	1220862	6436	78517040
Respiratory acidosis	14.98	11.34	105	1220807	11095	78512381
Hallucination	14.92	11.34	1120	1219792	84625	78438851
Coeliac disease	14.89	11.34	107	1220805	11244	78512232
Cerebral artery occlusion	14.89	11.34	59	1220853	1663	78521813
Analgesic drug level increased	14.86	11.34	16	1220896	3162	78520314
Tenosynovitis	14.84	11.34	327	1220585	15227	78508249
Laryngeal pain	14.81	11.34	151	1220761	5963	78517513
Latent tuberculosis	14.81	11.34	95	1220817	3258	78520218
Barrett's oesophagus	14.80	11.34	36	1220876	773	78522703
Stress fracture	14.74	11.34	158	1220754	6322	78517154
Atrioventricular block first degree	14.71	11.34	271	1220641	12220	78511256
Pharyngeal haemorrhage	14.70	11.34	49	1220863	1267	78522209
Bronchospasm	14.66	11.34	280	1220632	24579	78498897
Bacterial sepsis	14.64	11.34	70	1220842	8128	78515348
Back disorder	14.63	11.34	254	1220658	11324	78512152
Electrocardiogram ST-T change	14.62	11.34	56	1220856	1553	78521923
Metastases to peritoneum	14.53	11.34	28	1220884	4344	78519132
Twin pregnancy	14.44	11.34	38	1220874	858	78522618
Obliterative bronchiolitis	14.43	11.34	15	1220897	3013	78520463
Fusarium infection	14.43	11.34	5	1220907	1827	78521649
Myositis	14.38	11.34	390	1220522	18778	78504698
Peritonitis bacterial	14.38	11.34	216	1220696	9351	78514125
Coronary artery embolism	14.36	11.34	21	1220891	301	78523175
Glomerular filtration rate increased	14.34	11.34	46	1220866	1165	78522311
Myocarditis	14.33	11.34	240	1220672	21493	78501983
Procedural complication	14.33	11.34	186	1220726	7797	78515679
Costochondritis	14.31	11.34	75	1220837	2386	78521090
Inappropriate schedule of product administration	14.30	11.34	1809	1219103	131819	78391657
Hyperhidrosis	14.29	11.34	2067	1218845	149425	78374051
Nephrocalcinosis	14.25	11.34	53	1220859	1449	78522027
Skin plaque	14.24	11.34	101	1220811	10644	78512832
Type 1 diabetes mellitus	14.24	11.34	56	1220856	6863	78516613
Cardiac operation	14.23	11.34	128	1220784	4884	78518592
Pneumonia viral	14.23	11.34	82	1220830	9076	78514400
Foot fracture	14.22	11.34	439	1220473	21542	78501934
Lung disorder	14.21	11.34	1051	1219861	79506	78443970
Basilar artery thrombosis	14.21	11.34	23	1220889	362	78523114
Arteriogram coronary abnormal	14.21	11.34	6	1220906	8	78523468
Panic attack	14.20	11.34	273	1220639	23943	78499533
Limb injury	14.20	11.34	570	1220342	28958	78494518
Shunt thrombosis	14.17	11.34	15	1220897	151	78523325
Hypernatraemia	14.15	11.34	147	1220765	14304	78509172
Blood HIV RNA increased	14.13	11.34	5	1220907	1803	78521673
Gastritis haemorrhagic	14.11	11.34	79	1220833	2578	78520898
Diarrhoea	14.06	11.34	12873	1208039	867616	77655860
Vascular stent occlusion	14.04	11.34	18	1220894	226	78523250
Sexual dysfunction	14.03	11.34	66	1220846	7697	78515779
Spinal disorder	14.03	11.34	228	1220684	10032	78513444
Eructation	14.03	11.34	240	1220672	10669	78512807
Tremor	14.00	11.34	2339	1218573	167744	78355732
Hypertriglyceridaemia	13.99	11.34	126	1220786	12614	78510862
Gastric cancer stage IV	13.99	11.34	3	1220909	1507	78521969
Palmoplantar keratoderma	13.99	11.34	22	1220890	3694	78519782
Lymphadenopathy	13.99	11.34	669	1220243	52578	78470898
Cardiospasm	13.96	11.34	18	1220894	3283	78520193
Cytomegalovirus enterocolitis	13.96	11.34	4	1220908	1651	78521825
Nephropathy toxic	13.96	11.34	224	1220688	20195	78503281
Hyperammonaemic encephalopathy	13.92	11.34	33	1220879	4749	78518727
Product substitution issue	13.91	11.34	222	1220690	20034	78503442
Pneumonia bacterial	13.91	11.34	210	1220702	19121	78504355
Skin laceration	13.91	11.34	559	1220353	28403	78495073
Vascular dementia	13.88	11.34	37	1220875	842	78522634
Hereditary angioedema	13.85	11.34	39	1220873	5296	78518180
Drug screen positive	13.84	11.34	47	1220865	6016	78517460
Oesophageal intramural haematoma	13.82	11.34	13	1220899	112	78523364
Electrocardiogram QRS complex prolonged	13.79	11.34	103	1220809	10730	78512746
Lichen planopilaris	13.78	11.34	9	1220903	42	78523434
Agonal rhythm	13.78	11.34	11	1220901	74	78523402
Clonus	13.67	11.34	56	1220856	6784	78516692
Lung neoplasm	13.67	11.34	167	1220745	6902	78516574
Cystic fibrosis	13.65	11.34	24	1220888	3856	78519620
Gestational diabetes	13.65	11.34	152	1220760	6141	78517335
Brain abscess	13.63	11.34	35	1220877	4901	78518575
Neck deformity	13.59	11.34	60	1220852	1777	78521699
Sinus tachycardia	13.54	11.34	446	1220466	36462	78487014
Intestinal pseudo-obstruction	13.51	11.34	12	1220900	2597	78520879
Spinal cord herniation	13.44	11.34	6	1220906	10	78523466
Disinhibition	13.40	11.34	12	1220900	2586	78520890
Atrioventricular block second degree	13.39	11.34	171	1220741	7141	78516335
Oesophagitis	13.39	11.34	476	1220436	23813	78499663
Hyperpyrexia	13.39	11.34	48	1220864	6044	78517432
Large intestinal ulcer	13.36	11.34	122	1220790	4675	78518801
Dieulafoy's vascular malformation	13.36	11.34	8	1220904	31	78523445
Hernia	13.35	11.34	349	1220563	16710	78506766
Device interaction	13.32	11.34	33	1220879	717	78522759
Heart valve stenosis	13.31	11.34	15	1220897	163	78523313
Vascular calcification	13.22	11.34	42	1220870	1058	78522418
Peritoneal dialysis complication	13.18	11.34	71	1220841	2283	78521193
Infusion site pain	13.16	11.34	146	1220766	14030	78509446
Neoplasm recurrence	13.15	11.34	28	1220884	4186	78519290
Ulcer haemorrhage	13.12	11.34	142	1220770	5696	78517780
Acute chest syndrome	13.11	11.34	53	1220859	1508	78521968
Pain in jaw	13.10	11.34	575	1220337	45576	78477900
Maternal exposure before pregnancy	13.10	11.34	113	1220799	4260	78519216
Open reduction of fracture	13.09	11.34	18	1220894	243	78523233
Gastric ulcer perforation	13.06	11.34	66	1220846	2069	78521407
Brain stem infarction	13.06	11.34	63	1220849	1938	78521538
Antipsychotic drug level increased	13.05	11.34	47	1220865	5910	78517566
Diffuse large B-cell lymphoma refractory	13.00	11.34	3	1220909	1432	78522044
Anaemia macrocytic	12.98	11.34	137	1220775	5460	78518016
Haemorrhage urinary tract	12.96	11.34	73	1220839	2388	78521088
Aneurysm ruptured	12.94	11.34	38	1220874	916	78522560
Metastases to meninges	12.92	11.34	22	1220890	3579	78519897
Iron deficiency anaemia	12.91	11.34	498	1220414	25174	78498302
Stress cardiomyopathy	12.90	11.34	109	1220803	11057	78512419
Enterobacter infection	12.87	11.34	32	1220880	4530	78518946
Rhinitis perennial	12.86	11.34	21	1220891	333	78523143
Joint injury	12.86	11.34	595	1220317	30740	78492736
Blood pressure inadequately controlled	12.86	11.34	148	1220764	6029	78517447
Diabetic ketoacidosis	12.84	11.34	411	1220501	33711	78489765
Angiogram abnormal	12.81	11.34	8	1220904	34	78523442
Pericardial disease	12.81	11.34	28	1220884	559	78522917
Joint destruction	12.80	11.34	143	1220769	5782	78517694
Blood cholesterol increased	12.80	11.34	1467	1219445	82253	78441223
Excessive eye blinking	12.79	11.34	5	1220907	1696	78521780
Skin haemorrhage	12.77	11.34	256	1220656	11725	78511751
Lactic acidosis	12.73	11.34	916	1219996	69443	78454033
Hypersensitivity myocarditis	12.72	11.34	18	1220894	250	78523226
Intentional product use issue	12.72	11.34	2090	1218822	150022	78373454
Bone disorder	12.71	11.34	383	1220529	18730	78504746
Colonic haematoma	12.71	11.34	11	1220901	84	78523392
Vitamin B12 deficiency	12.70	11.34	168	1220744	7073	78516403
Ventricular asystole	12.67	11.34	19	1220893	279	78523197
Engraftment syndrome	12.65	11.34	3	1220909	1406	78522070
Somnambulism	12.62	11.34	45	1220867	5676	78517800
Nasal obstruction	12.62	11.34	66	1220846	2098	78521378
Oral allergy syndrome	12.61	11.34	11	1220901	85	78523391
QRS axis abnormal	12.61	11.34	64	1220848	2010	78521466
Antinuclear antibody positive	12.59	11.34	180	1220732	7710	78515766
Flap necrosis	12.58	11.34	5	1220907	5	78523471
Lumbar spinal stenosis	12.58	11.34	130	1220782	5152	78518324
Gastrointestinal ulcer haemorrhage	12.58	11.34	46	1220866	1247	78522229
Retinal artery occlusion	12.56	11.34	90	1220822	3204	78520272
Dementia	12.56	11.34	479	1220433	24180	78499296
Nephrogenic systemic fibrosis	12.56	11.34	147	1220765	6013	78517463
Crying	12.55	11.34	263	1220649	22780	78500696
Compartment syndrome	12.55	11.34	126	1220786	4956	78518520
Haptoglobin increased	12.53	11.34	16	1220896	200	78523276
Small intestine polyp	12.53	11.34	7	1220905	23	78523453
Colitis	12.52	11.34	959	1219953	72348	78451128
Carotid artery occlusion	12.42	11.34	175	1220737	7472	78516004
Computerised tomogram coronary artery abnormal	12.42	11.34	16	1220896	202	78523274
Cognitive disorder	12.38	11.34	912	1220000	69014	78454462
Extremity contracture	12.38	11.34	56	1220856	1676	78521800
Unintended pregnancy	12.38	11.34	26	1220886	3907	78519569
Feeling of despair	12.33	11.34	15	1220897	2806	78520670
Post procedural drainage	12.32	11.34	9	1220903	52	78523424
Tardive dyskinesia	12.30	11.34	103	1220809	10468	78513008
Rotator cuff repair	12.29	11.34	59	1220853	1811	78521665
Vasoplegia syndrome	12.29	11.34	23	1220889	3607	78519869
Subclavian artery stenosis	12.28	11.34	17	1220895	231	78523245
Erythema multiforme	12.28	11.34	193	1220719	17458	78506018
Granulomatous pneumonitis	12.22	11.34	11	1220901	89	78523387
Complications of transplanted kidney	12.18	11.34	53	1220859	6313	78517163
Diverticulitis	12.16	11.34	838	1220074	45098	78478378
Aortic valve replacement	12.14	11.34	46	1220866	1269	78522207
Carpal tunnel syndrome	12.11	11.34	388	1220524	19140	78504336
Cerebral toxoplasmosis	12.07	11.34	11	1220901	2351	78521125
Nephrogenic diabetes insipidus	12.07	11.34	9	1220903	2125	78521351
Dyspnoea	12.07	11.34	13685	1207227	843340	77680136
Pseudomonal sepsis	12.06	11.34	51	1220861	6123	78517353
Prescription drug used without a prescription	12.04	11.34	28	1220884	4057	78519419
Gene mutation	12.04	11.34	14	1220898	2672	78520804
Ventricle rupture	12.04	11.34	11	1220901	91	78523385
Ileus paralytic	11.99	11.34	92	1220820	9528	78513948
Multiple fractures	11.98	11.34	181	1220731	7845	78515631
Device use issue	11.96	11.34	15	1220897	2769	78520707
Foetal growth restriction	11.93	11.34	64	1220848	2055	78521421
Mycobacterium chelonae infection	11.90	11.34	12	1220900	2444	78521032
Leukaemia recurrent	11.86	11.34	15	1220897	2759	78520717
Hepatitis fulminant	11.84	11.34	64	1220848	7198	78516278
HELLP syndrome	11.80	11.34	33	1220879	773	78522703
Fulminant type 1 diabetes mellitus	11.76	11.34	4	1220908	1479	78521997
Long QT syndrome	11.75	11.34	49	1220863	5906	78517570
Infection reactivation	11.75	11.34	14	1220898	2643	78520833
Gamma-glutamyltransferase increased	11.74	11.34	701	1220211	53979	78469497
Mitral valve stenosis	11.73	11.34	43	1220869	1167	78522309
Essential hypertension	11.70	11.34	143	1220769	5910	78517566
Fat embolism	11.69	11.34	23	1220889	425	78523051
Depersonalisation/derealisation disorder	11.68	11.34	7	1220905	1855	78521621
Thrombolysis	11.66	11.34	17	1220895	243	78523233
Red blood cells urine positive	11.65	11.34	38	1220874	4925	78518551
Body temperature decreased	11.65	11.34	603	1220309	31542	78491934
Haemorrhagic infarction	11.64	11.34	32	1220880	742	78522734
Ulcer	11.63	11.34	566	1220346	29406	78494070
Tongue haematoma	11.63	11.34	16	1220896	216	78523260
Therapy non-responder	11.62	11.34	1236	1219676	91069	78432407
Body tinea	11.59	11.34	7	1220905	1847	78521629
Blood pressure systolic decreased	11.58	11.34	236	1220676	10840	78512636
Stenosis	11.56	11.34	70	1220842	2352	78521124
Thalamus haemorrhage	11.55	11.34	56	1220856	1726	78521750
Joint noise	11.55	11.34	102	1220810	3872	78519604
Dependence	11.54	11.34	12	1220900	2410	78521066
Post procedural myocardial infarction	11.54	11.34	8	1220904	42	78523434
Type I hypersensitivity	11.53	11.34	32	1220880	4366	78519110
Hand-eye coordination impaired	11.52	11.34	7	1220905	28	78523448
Vascular procedure complication	11.52	11.34	7	1220905	28	78523448
Dactylitis	11.50	11.34	77	1220835	2680	78520796
Capillary leak syndrome	11.49	11.34	27	1220885	3898	78519578
Wrist fracture	11.49	11.34	251	1220661	11670	78511806
Differentiation syndrome	11.48	11.34	13	1220899	2511	78520965
Device physical property issue	11.48	11.34	14	1220898	2616	78520860
Gangrene	11.45	11.34	197	1220715	8767	78514709
Drug-induced liver injury	11.44	11.34	864	1220048	65253	78458223
Liver function test abnormal	11.42	11.34	1141	1219771	63334	78460142
Myocardial necrosis marker increased	11.41	11.34	87	1220825	3159	78520317
Middle insomnia	11.41	11.34	175	1220737	15894	78507582
Salivary gland calculus	11.41	11.34	17	1220895	248	78523228
Vascular occlusion	11.41	11.34	50	1220862	1476	78522000
Intracranial haematoma	11.40	11.34	36	1220876	904	78522572
Tooth disorder	11.39	11.34	501	1220411	25732	78497744
Coronary artery dissection	11.39	11.34	41	1220871	1103	78522373
Puncture site reaction	11.37	11.34	6	1220906	17	78523459
Deep vein thrombosis	11.36	11.34	2060	1218852	118859	78404617
Foetal distress syndrome	11.34	11.34	24	1220888	468	78523008

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02AC01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS ANTACIDS Calcium compounds
ATC	A12AA04	ALIMENTARY TRACT AND METABOLISM MINERAL SUPPLEMENTS CALCIUM Calcium
CHEBI has role	CHEBI:33287	fertilizers
CHEBI has role	CHEBI:65265	antacids
CHEBI has role	CHEBI:77182	food coloring
CHEBI has role	CHEBI:77960	firming agents
MeSH PA	D000863	Antacids
MeSH PA	D005765	Gastrointestinal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypocalcemia	indication	5291005
Indigestion	indication	162031009
Heartburn Prevention	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
H0G9379FGK	UNII
4019035	VUID
N0000147306	NUI
4017644	VANDF
4019033	VANDF
4019035	VANDF
C0006681	UMLSCUI
CHEBI:3311	CHEBI
CHEMBL1200539	ChEMBL_ID
10112	PUBCHEM_CID
DB06724	DRUGBANK_ID
D002119	MESH_DESCRIPTOR_UI
1897	RXNORM
10153	MMSL
41410	MMSL
4326	MMSL
4330	MMSL
6070	MMSL
d00425	MMSL
000773	NDDF
001117	NDDF
387307005	SNOMEDCT_US
55217007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0054-3117	SUSPENSION	1250 mg	ORAL	OTC monograph final	11 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0054-3117	SUSPENSION	1250 mg	ORAL	OTC monograph final	11 sections
Gas-XTotal Relief Maximum Strength	HUMAN OTC DRUG LABEL	2	0067-0118	TABLET, CHEWABLE	750 mg	ORAL	OTC monograph final	14 sections
Gas-XTotal Relief Maximum Strength	HUMAN OTC DRUG LABEL	2	0067-0118	TABLET, CHEWABLE	750 mg	ORAL	OTC monograph final	14 sections
Gas-XTotal Relief Maximum Strength	HUMAN OTC DRUG LABEL	2	0067-0119	TABLET, CHEWABLE	750 mg	ORAL	OTC monograph final	14 sections
Gas-XTotal Relief Maximum Strength	HUMAN OTC DRUG LABEL	2	0067-0119	TABLET, CHEWABLE	750 mg	ORAL	OTC monograph final	14 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
Good Sense Dual Action Complete	HUMAN OTC DRUG LABEL	3	0113-0032	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
good sense antacid	HUMAN OTC DRUG LABEL	1	0113-0962	TABLET, CHEWABLE	1000 mg	ORAL	OTC monograph final	11 sections
good sense antacid	HUMAN OTC DRUG LABEL	1	0113-0962	TABLET, CHEWABLE	1000 mg	ORAL	OTC monograph final	11 sections
injoy heartburn relief	HUMAN OTC DRUG LABEL	3	0113-6023	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
injoy heartburn relief	HUMAN OTC DRUG LABEL	3	0113-6023	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
basic care dual action complete	HUMAN OTC DRUG LABEL	3	0113-7321	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
basic care dual action complete	HUMAN OTC DRUG LABEL	3	0113-7321	TABLET, CHEWABLE	800 mg	ORAL	ANDA	15 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-0766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-0766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-0766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-0766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-0766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-0766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-4766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-4766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-4766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-4766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-4766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
Calcium Carbonate	HUMAN OTC DRUG LABEL	1	0121-4766	SUSPENSION	1250 mg	ORAL	OTC monograph final	13 sections
PHAZYME	HUMAN OTC DRUG LABEL	2	0132-0507	TABLET, CHEWABLE	750 mg	ORAL	OTC monograph final	11 sections
TUMS	HUMAN OTC DRUG LABEL	1	0135-0070	TABLET	500 mg	ORAL	OTC monograph final	12 sections