octinoxate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4236	5466-77-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: octyl methoxycinnamate octinoxate ethylhexyl methoxycinnamate ethylhexyl p-methoxycinnamate Parsol MOX Eusolex 2292 parsol methoxycinnamate	a UV filter compound Molecular weight: 290.40 Formula: C18H26O3 CLOGP: 5.96 LIPINSKI: 1 HAC: 3 HDO: 0 TPSA: 35.53 ALOGS: -5.81 ROTB: 10 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

octyl methoxycinnamate
octinoxate
ethylhexyl methoxycinnamate
ethylhexyl p-methoxycinnamate
Parsol MOX
Eusolex 2292
parsol
methoxycinnamate

a UV filter compound

Molecular weight: 290.40
Formula: C18H26O3
CLOGP: 5.96
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 35.53
ALOGS: -5.81
ROTB: 10

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 7, 1992	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	837.90	21.55	216	4202	24160	63460444
Chronic sinusitis	254.32	21.55	74	4344	12769	63471835
Paraesthesia oral	224.79	21.55	74	4344	19182	63465422
Procedural pain	216.55	21.55	74	4344	21495	63463109
Drug ineffective	142.88	21.55	256	4162	1044509	62440095
Vaginal flatulence	131.36	21.55	33	4385	3260	63481344
Therapeutic product effect incomplete	127.37	21.55	89	4329	124967	63359637
Squamous cell carcinoma of skin	119.81	21.55	35	4383	6097	63478507
Proctitis	114.93	21.55	33	4385	5408	63479196
Dyspepsia	114.09	21.55	77	4341	102119	63382485
Female genital tract fistula	108.39	21.55	34	4384	7525	63477079
Radiculopathy	100.00	21.55	33	4385	8578	63476026
Vaginal discharge	97.87	21.55	33	4385	9165	63475439
Colitis ulcerative	70.50	21.55	35	4383	26056	63458548
Skin atrophy	70.04	21.55	22	4396	4884	63479720
Oral candidiasis	68.85	21.55	33	4385	22765	63461839
Frequent bowel movements	68.55	21.55	33	4385	22989	63461615
Weight decreased	63.96	21.55	87	4331	276711	63207893
Colitis	57.50	21.55	38	4380	48490	63436114
Pyrexia	56.73	21.55	110	4308	470368	63014236
Neoplasm skin	54.16	21.55	14	4404	1547	63483057
Rectal haemorrhage	52.36	21.55	36	4382	48994	63435610
Infusion related reaction	51.93	21.55	74	4344	245447	63239157
Haematochezia	49.50	21.55	36	4382	53508	63431096
Ochronosis	46.69	21.55	7	4411	40	63484564
Malaise	33.72	21.55	83	4335	415871	63068733
Nausea	27.08	21.55	124	4294	854347	62630257
Constipation	23.86	21.55	50	4368	224893	63259711

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anal inflammation	96.40	27.34	20	1591	1280	34954040
SARS-CoV-2 test negative	83.28	27.34	17	1594	1003	34954317
Accident	69.44	27.34	20	1591	5027	34950293
Proctalgia	66.96	27.34	20	1591	5703	34949617
Haemorrhoids	48.66	27.34	20	1591	14555	34940765
Body temperature increased	45.28	27.34	20	1591	17348	34937972
Appendicolith	43.64	27.34	16	1595	8585	34946735
Appendicitis	35.23	27.34	16	1595	14791	34940529
Ventricular fibrillation	31.35	27.34	17	1594	22937	34932383
Cardiogenic shock	29.00	27.34	17	1594	26601	34928719

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	255.42	18.92	72	5406	11224	79727686
Chronic sinusitis	245.28	18.92	72	5406	12954	79725956
Paraesthesia oral	213.24	18.92	72	5406	20399	79718511
Procedural pain	204.76	18.92	72	5406	23012	79715898
Vaginal flatulence	134.61	18.92	32	5446	2543	79736367
Therapeutic product effect incomplete	122.78	18.92	91	5387	141554	79597356
Female genital tract fistula	112.28	18.92	33	5445	5942	79732968
Dyspepsia	105.92	18.92	75	5403	108612	79630298
Proctitis	105.57	18.92	32	5446	6400	79732510
Vaginal discharge	100.89	18.92	32	5446	7431	79731479
Squamous cell carcinoma of skin	99.04	18.92	37	5441	13996	79724914
Radiculopathy	95.62	18.92	32	5446	8792	79730118
Anal inflammation	81.16	18.92	19	5459	1411	79737499
Skin atrophy	71.05	18.92	23	5455	5695	79733215
SARS-CoV-2 test negative	66.28	18.92	16	5462	1355	79737555
Pyrexia	65.89	18.92	144	5334	678565	79060345
Frequent bowel movements	61.15	18.92	33	5445	29506	79709404
Colitis ulcerative	58.80	18.92	34	5444	34708	79704202
Oral candidiasis	58.28	18.92	32	5446	29596	79709314
Infusion related reaction	57.87	18.92	75	5403	230162	79508748
Weight decreased	57.63	18.92	94	5384	355104	79383806
Neoplasm skin	53.89	18.92	14	5464	1597	79737313
Proctalgia	48.14	18.92	20	5458	9981	79728929
Accident	47.08	18.92	19	5459	8812	79730098
Malaise	46.32	18.92	103	5375	489766	79249144
Ochronosis	44.62	18.92	7	5471	57	79738853
Colitis	43.93	18.92	38	5440	73269	79665641
Rectal haemorrhage	42.62	18.92	38	5440	76262	79662648
Constipation	39.35	18.92	70	5408	282980	79455930
Appendicolith	37.48	18.92	16	5462	8535	79730375
Haematochezia	34.48	18.92	36	5442	87609	79651301
Pain	33.41	18.92	115	5363	703687	79035223
Nausea	31.30	18.92	139	5339	957057	78781853
Haemorrhoids	25.79	18.92	19	5459	29109	79709801
Appendicitis	24.10	18.92	16	5462	20778	79718132
Off label use	23.98	18.92	124	5354	907091	78831819
Body temperature increased	20.68	18.92	20	5458	44400	79694510
Ventricular fibrillation	20.03	18.92	17	5461	31909	79707001
Anal injury	19.41	18.92	4	5474	164	79738746

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D02BA02	DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES PROTECTIVES AGAINST UV-RADIATION Protectives against UV-radiation for topical use
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Discoloration of skin	indication	3253007
Chloasma	indication	36209000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4Y5P7MUD51	UNII
4025697	VUID
N0000179014	NUI
D05225	KEGG_DRUG
4020294	VANDF
4020377	VANDF
4020661	VANDF
4025697	VANDF
C0046100	UMLSCUI
CHEBI:134750	CHEBI
CHEMBL3183184	ChEMBL_ID
CHEMBL1200608	ChEMBL_ID
5355130	PUBCHEM_CID
DB09496	DRUGBANK_ID
7945	INN_ID
C118580	MESH_SUPPLEMENTAL_RECORD_UI
C516303	MESH_SUPPLEMENTAL_RECORD_UI
13369	RXNORM
003659	NDDF
007440	NDDF
255902000	SNOMEDCT_US
411144000	SNOMEDCT_US
83834-59-7	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen	HUMAN OTC DRUG LABEL	3	0023-5494	LOTION	75 mg	TOPICAL	OTC monograph not final	12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen	HUMAN OTC DRUG LABEL	3	0023-5494	LOTION	75 mg	TOPICAL	OTC monograph not final	12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted)	HUMAN OTC DRUG LABEL	4	0023-5497	LOTION	75 mg	TOPICAL	OTC monograph not final	12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted)	HUMAN OTC DRUG LABEL	4	0023-5497	LOTION	75 mg	TOPICAL	OTC monograph not final	12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen	HUMAN OTC DRUG LABEL	4	0023-5501	LOTION	75 mg	TOPICAL	OTC monograph not final	8 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen	HUMAN OTC DRUG LABEL	2	0023-5738	LOTION	75 mg	TOPICAL	OTC monograph not final	8 sections
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Zinc SPF38	HUMAN OTC DRUG LABEL	3	0096-0688	CREAM	0.08 1	TOPICAL	OTC monograph final	8 sections
Solbar Zinc SPF38	HUMAN OTC DRUG LABEL	3	0096-0688	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Daily Facial MoisturizerSPF 25	HUMAN OTC DRUG LABEL	4	0096-0721	CREAM	0.08 g	TOPICAL	OTC monograph final	11 sections
Solbar Fifty SPF50	HUMAN OTC DRUG LABEL	4	0096-0741	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Fifty SPF50	HUMAN OTC DRUG LABEL	4	0096-0741	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Purpose	HUMAN OTC DRUG LABEL	3	0187-5500	LOTION	76 mg	TOPICAL	OTC monograph not final	9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	75 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	75 mg	TOPICAL	OTC monograph final	11 sections
Almay Wake-Up Liquid Make-Up	HUMAN OTC DRUG LABEL	2	0311-0704	LIQUID	3.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Smart Shade CC Cream	HUMAN OTC DRUG LABEL	3	0311-0705	LIQUID	7.50 mg	TOPICAL	OTC monograph final	6 sections
Almay Age Essentials Makeup SPF 15	HUMAN OTC DRUG LABEL	2	0311-0707	LIQUID	3.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Age Essentials Concealer SPF 20	HUMAN OTC DRUG LABEL	2	0311-0708	LIQUID	7.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	7.50 mg	TOPICAL	OTC monograph final	8 sections
Almay Best Blend Forever Makeup	HUMAN OTC DRUG LABEL	4	0311-0719	LOTION	7.50 mg	TOPICAL	OTC monograph final	5 sections
Blue Lizard Regular	HUMAN OTC DRUG LABEL	4	0316-2010	LOTION	76.50 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Sport Original Sunscreen	HUMAN OTC DRUG LABEL	4	0316-2019	LOTION	76.50 mg	TOPICAL	OTC monograph not final	8 sections
Blue Lizard Face	HUMAN OTC DRUG LABEL	2	0316-2055	GEL	55 mg	TOPICAL	OTC monograph not final	8 sections
Blue Lizard Face	HUMAN OTC DRUG LABEL	2	0316-2055	GEL	55 mg	TOPICAL	OTC monograph not final	8 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen	HUMAN OTC DRUG LABEL	3	0363-0696	CREAM	10 g	TOPICAL	OTC monograph not final	12 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0940	LOTION	75 mg	TOPICAL	OTC monograph not final	13 sections