methyldopate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4218 | 6014-30-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 20, 1962 | FDA | MERCK |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D058647 | Adrenergic alpha-2 Receptor Agonists |
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D013565 | Sympatholytics |
| CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Parkinsonism | contraindication | 32798002 | |
| Depressive disorder | contraindication | 35489007 | |
| Acute hepatitis | contraindication | 37871000 | |
| Chronic heart failure | contraindication | 48447003 | |
| Hepatic failure | contraindication | 59927004 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Angina pectoris | contraindication | 194828000 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Edema | contraindication | 267038008 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pheochromocytoma | contraindication | 302835009 | |
| Autoimmune hemolytic anemia | contraindication | 413603009 | DOID:718 |
| Porphyria | contraindication | 418470004 | |
| Severe Cerebrovascular Disease | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.7 | acidic |
| pKa2 | 12.7 | acidic |
| pKa3 | 7.13 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | GPCR | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4022151 | VUID |
| N0000020157 | NUI |
| D04997 | KEGG_DRUG |
| 2508-79-4 | SECONDARY_CAS_RN |
| 4017963 | VANDF |
| 4022151 | VANDF |
| C0025744 | UMLSCUI |
| CHEBI:94761 | CHEBI |
| CHEMBL1201233 | ChEMBL_ID |
| CHEMBL1200432 | ChEMBL_ID |
| D008750 | MESH_DESCRIPTOR_UI |
| 2579Z4P04J | UNII |
| 17277 | PUBCHEM_CID |
| 6877 | RXNORM |
| 5089 | MMSL |
| 7929 | MMSL |
| 000647 | NDDF |
| 005167 | NDDF |
| 21566004 | SNOMEDCT_US |
| 782181004 | SNOMEDCT_US |
Pharmaceutical products:
None