buclizine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diphenylmethyl piperazine derivatives | 416 | 82-95-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | STUART PHARMS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R06AE01 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Piperazine derivatives |
| ATC | R06AE51 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Piperazine derivatives |
| CHEBI has role | CHEBI:35488 | central nervous system depressants |
| CHEBI has role | CHEBI:36333 | local anesthetics |
| CHEBI has role | CHEBI:37956 | antihistamines |
| CHEBI has role | CHEBI:48873 | acetylcholine receptor antagonist |
| CHEBI has role | CHEBI:50919 | antiemetico |
| MeSH PA | D018494 | Histamine Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Motion sickness | indication | 37031009 | DOID:2951 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.15 | Basic |
| pKa2 | 3.15 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | GPCR | ANTAGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019642 | VUID |
| N0000147735 | NUI |
| D02089 | KEGG_DRUG |
| 59636 | RXNORM |
| C0164386 | UMLSCUI |
| CHEBI:3205 | CHEBI |
| CHEMBL1201271 | ChEMBL_ID |
| DB00354 | DRUGBANK_ID |
| C046894 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6729 | PUBCHEM_CID |
| 7134 | IUPHAR_LIGAND_ID |
| 291 | INN_ID |
| 129-74-8 | SECONDARY_CAS_RN |
| 0C94V6X681 | UNII |
| 1956002 | SNOMEDCT_US |
| 387344005 | SNOMEDCT_US |
| 61623002 | SNOMEDCT_US |
| CHEMBL2360580 | ChEMBL_ID |
| CHEMBL1200403 | ChEMBL_ID |
| 4018463 | VANDF |
| 4019642 | VANDF |
| 003404 | NDDF |
| 004801 | NDDF |
Pharmaceutical products:
None