lutein 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4145	127-40-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: lutein xanthophyll	A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA. Molecular weight: 568.89 Formula: C40H56O2 CLOGP: 11.23 LIPINSKI: 2 HAC: 2 HDO: 2 TPSA: 40.46 ALOGS: -5.89 ROTB: 10

Molecule

Description

Molfile Inchi Smiles

Synonyms:

lutein
xanthophyll

A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.

Molecular weight: 568.89
Formula: C40H56O2
CLOGP: 11.23
LIPINSKI: 2
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: -5.89
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fall	27.31	19.37	60	3087	392274	63093601
Macular degeneration	21.53	19.37	14	3133	24362	63461513

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	122.78	33.05	37	2012	8564	34946318
Blood phosphorus increased	117.93	33.05	35	2014	7686	34947196
Appendicitis	103.03	33.05	37	2012	14770	34940112
Ventricular fibrillation	87.28	33.05	37	2012	22917	34931965
Stress	83.54	33.05	39	2010	30308	34924574
Cardiogenic shock	82.01	33.05	37	2012	26581	34928301
Dry mouth	71.53	33.05	35	2014	30130	34924752
Ascites	65.10	33.05	38	2011	46533	34908349
Myasthenia gravis	62.33	33.05	21	2028	6919	34947963
Blood uric acid increased	59.28	33.05	22	2027	9602	34945280

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	126.63	21.15	37	4174	8514	79731663
Blood phosphorus increased	111.28	21.15	35	4176	10312	79729865
Appendicitis	97.93	21.15	38	4173	20756	79719421
Ventricular fibrillation	85.36	21.15	39	4172	31887	79708290
Cardiogenic shock	69.57	21.15	37	4174	41877	79698300
Stress	68.47	21.15	46	4165	79566	79660611
Myasthenia gravis	59.79	21.15	22	4189	10377	79729800
Blood uric acid increased	54.44	21.15	22	4189	13338	79726839
Abdominal distension	53.83	21.15	47	4164	119603	79620574
Dry mouth	50.90	21.15	40	4171	87979	79652198

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77182	food coloring

Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Tear film insufficiency	indication	46152009
Age related macular degeneration	indication	267718000	DOID:10871
Meibomian gland dysfunction	indication	397549002

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
LUT	PDB_CHEM_ID
008098	NDDF
009220	NDDF
11359	RXNORM
117565	MMSL
24043	MMSL
4024342	VUID
4024342	VANDF
5281243	PUBCHEM_CID
C0043328	UMLSCUI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Furryden Dental Easy Green	HUMAN OTC DRUG LABEL	2	83332-401	GUM, CHEWING	0.01 g	ORAL	unapproved drug other	11 sections
Noon for Kids	HUMAN OTC DRUG LABEL	1	82597-010	POWDER	10 mg	ORAL	unapproved drug other	10 sections
Ocuvel	HUMAN PRESCRIPTION DRUG LABEL	7	69054-210	CAPSULE	10 mg	ORAL	unapproved drug other	9 sections
Ocuvel	HUMAN PRESCRIPTION DRUG LABEL	7	69054-211	CAPSULE	5 mg	ORAL	unapproved drug other	9 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	5 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	5 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Vista Advanced Carotenoid Formula	HUMAN OTC DRUG LABEL	7	77790-007	CAPSULE	5 mg	ORAL	unapproved drug other	10 sections

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