All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

pyridoxal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4134	65-22-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pyridoxal pyridoxaldehyde	The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Molecular weight: 167.16 Formula: C8H9NO3 CLOGP: 1.18 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 70.42 ALOGS: -1.16 ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,ITK,JAK1,JAK2,KIT,MAP3K21,MAP3K7,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK	45
kinase-selectivity-class	ACVR2B,BRAF,GRK2,MAP2K6,PRKDC,TEK,TGFBR1	7
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	77.81	41.53	23	558	46265	90581601
Palmar-plantar erythrodysaesthesia syndrome	47.33	41.53	14	567	28009	90599857
Platelet count decreased	46.90	41.53	21	560	136948	90490918
Osteonecrosis of jaw	46.81	41.53	15	566	39088	90588778

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	58.28	36.58	25	491	78437	42542382
Hepatic function abnormal	36.76	36.58	16	500	51551	42569268

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	96.08	34.71	37	1273	89258	110498731
Interstitial lung disease	89.73	34.71	40	1270	139294	110448695
Palmar-plantar erythrodysaesthesia syndrome	66.39	34.71	23	1287	41002	110546987
Osteonecrosis of jaw	41.43	34.71	17	1293	48000	110539989
Platelet count decreased	40.16	34.71	28	1282	230415	110357574

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
MeSH PA	D018977	Micronutrients
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:75771	mouse metabolite
CHEBI has role	CHEBI:75772	<em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role	CHEBI:76971	<em>Escherichia coli</em> metabolite
CHEBI has role	CHEBI:77746	human metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.59	acidic
pKa2	12.8	acidic
pKa3	4.21	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		Ki	4.52		CHEMBL

External reference:

ID	Source
3THM379K8A	UNII
N0000008146	NUI
C0034263	UMLSCUI
CHEBI:17310	CHEBI
PXL	PDB_CHEM_ID
CHEMBL102970	ChEMBL_ID
1050	PUBCHEM_CID
DB00147	DRUGBANK_ID
D011730	MESH_DESCRIPTOR_UI
9002	RXNORM
019440	NDDF
430926008	SNOMEDCT_US
770955002	SNOMEDCT_US
66-72-8	SECONDARY_CAS_RN
3THM379K8A	INXIGHT DRUGS

Pharmaceutical products:

None