valine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4128 72-18-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valine
  • L-valine
A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.
  • Molecular weight: 117.15
  • Formula: C5H11NO2
  • CLOGP: -2.29
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: 0.26
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70 45
kinase-selectivity-class ACVR2B,AXL,CDK9,EIF2AK3,GRK2,MAP2K6,PIK3CD,TEK,TGFBR1 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lip dry 74.72 31.07 53 4691 100902 90522801
Back disorder 64.65 31.07 30 4714 25601 90598102
C-reactive protein abnormal 63.75 31.07 53 4691 127376 90496327
Dislocation of vertebra 49.94 31.07 33 4711 55935 90567768
Adjustment disorder with depressed mood 49.52 31.07 33 4711 56720 90566983
Rheumatoid factor positive 48.48 31.07 52 4692 171598 90452105
Injury 47.52 31.07 55 4689 197294 90426409
Breast cancer stage II 47.30 31.07 27 4717 35307 90588396
Oedema 45.20 31.07 54 4690 200241 90423462
Musculoskeletal pain 41.67 31.07 48 4696 171203 90452500
Incorrect route of product administration 38.39 31.07 27 4717 50599 90573104
Foetal growth restriction 36.80 31.07 15 4729 9365 90614338
Peripheral venous disease 36.02 31.07 32 4712 83889 90539814
Anti-cyclic citrullinated peptide antibody positive 33.75 31.07 51 4693 236382 90387321
Prescribed underdose 32.98 31.07 29 4715 74990 90548713
Delirium 31.90 31.07 33 4711 104326 90519377
Lower respiratory tract infection 31.51 31.07 51 4693 250608 90373095
Joint range of motion decreased 31.27 31.07 37 4707 135606 90488097

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lip dry 88.34 35.04 56 5075 100027 110484141
Back disorder 73.98 35.04 30 5101 20892 110563276
C-reactive protein abnormal 72.95 35.04 55 5076 129640 110454528
Rheumatoid factor positive 70.02 35.04 54 5077 131586 110452582
Dislocation of vertebra 63.98 35.04 34 5097 43687 110540481
Adjustment disorder with depressed mood 63.86 35.04 34 5097 43849 110540319
Injury 63.76 35.04 58 5073 177207 110406961
Breast cancer stage II 56.87 35.04 27 5104 27348 110556820
Oedema 53.66 35.04 57 5074 209919 110374249
Anti-cyclic citrullinated peptide antibody positive 52.99 35.04 53 5078 181931 110402237
Pemphigus 49.16 35.04 55 5076 214515 110369653
Discomfort 49.13 35.04 55 5076 214652 110369516
Glossodynia 47.63 35.04 55 5076 221949 110362219
Musculoskeletal pain 47.31 35.04 50 5081 182973 110401195
Peripheral venous disease 45.78 35.04 35 5096 84082 110500086
Hand deformity 44.98 35.04 53 5078 218453 110365715
Joint range of motion decreased 42.09 35.04 39 5092 121793 110462375
Lower respiratory tract infection 42.02 35.04 54 5077 243052 110341116
Wound 41.98 35.04 53 5078 234384 110349784
Systemic lupus erythematosus 41.64 35.04 55 5076 254283 110329885
Prescribed underdose 39.65 35.04 29 5102 65145 110519023
Facet joint syndrome 39.39 35.04 34 5097 96794 110487374
Prescribed overdose 38.18 35.04 32 5099 87549 110496619
Amnesia 36.90 35.04 34 5097 105374 110478794
Obesity 36.68 35.04 35 5096 113316 110470852
Incorrect route of product administration 35.61 35.04 27 5104 64034 110520134
Synovitis 35.53 35.04 53 5078 274039 110310129

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:27027 micronutrient
CHEBI has role CHEBI:50733 nutraceutical
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:84735 algal metabolite
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:83056 <em>Daphnia magna</em> metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.49 acidic
pKa2 9.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Large neutral amino acids transporter small subunit 1 Transporter IC50 4.17 CHEMBL

External reference:

IDSource
4018679 VUID
N0000146990 NUI
D00039 KEGG_DRUG
4018679 VANDF
C0042285 UMLSCUI
CHEBI:16414 CHEBI
VAL PDB_CHEM_ID
CHEMBL43068 ChEMBL_ID
D014633 MESH_DESCRIPTOR_UI
DB00161 DRUGBANK_ID
6175 INN_ID
HG18B9YRS7 UNII
6287 PUBCHEM_CID
11115 RXNORM
15494 MMSL
236409 MMSL
40041 MMSL
NOCODE MMSL
d08094 MMSL
003652 NDDF
419086006 SNOMEDCT_US
72840006 SNOMEDCT_US
4794 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-1933 SOLUTION 0.78 g INTRAVENOUS NDA 23 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-4500 SOLUTION 960 mg INTRAVENOUS ANDA 20 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0180 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0184 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0188 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0194 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0198 INJECTION 348 mg INTRAVENOUS NDA 21 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0202 INJECTION 464 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0206 INJECTION 464 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0210 INJECTION 464 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0214 INJECTION 464 mg INTRAVENOUS NDA 20 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 1.44 g INTRAVENOUS NDA 21 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 960 mg INTRAVENOUS ANDA 18 sections
Travasol HUMAN PRESCRIPTION DRUG LABEL 15 0338-0644 INJECTION 580 mg INTRAVENOUS NDA 20 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1089 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1091 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1099 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1101 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1113 INJECTION 247 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1115 INJECTION 247 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1123 INJECTION 290 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1125 INJECTION 290 mg INTRAVENOUS NDA 20 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 0.78 g INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 0.47 g INTRAVENOUS ANDA 15 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1133 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1134 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1137 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1138 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1142 INJECTION 160 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1144 INJECTION 247 mg INTRAVENOUS NDA 20 sections