dexfosfoserine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives 4120 407-41-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phosphoserine
  • dexfosfoserine
  • fosforina
  • 3-O-Phosphoserine
  • L-Phosphoserine
  • seriphos
  • L-serine-O-phosphate
  • L-SOP
The phosphoric acid ester of serine.
  • Molecular weight: 185.07
  • Formula: C3H8NO6P
  • CLOGP: -4.46
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 130.08
  • ALOGS: -0.97
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.95 acidic
pKa2 1.56 acidic
pKa3 6.29 acidic
pKa4 9.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Metabotropic glutamate receptor 8 GPCR AGONIST IC50 7.20 IUPHAR
Metabotropic glutamate receptor 6 GPCR AGONIST EC50 6.40 IUPHAR
Metabotropic glutamate receptor 7 GPCR AGONIST EC50 4.50 IUPHAR
Metabotropic glutamate receptor 4 GPCR EC50 6 CHEMBL
Metabotropic glutamate receptor 4 GPCR EC50 5.40 CHEMBL
Metabotropic glutamate receptor 6 GPCR EC50 5.57 CHEMBL

External reference:

IDSource
CHEMBL284377 ChEMBL_ID
VI4F0K069V UNII
6888 INN_ID
SEP PDB_CHEM_ID
DB04522 DRUGBANK_ID
CHEBI:15811 CHEBI
D010768 MESH_DESCRIPTOR_UI
68841 PUBCHEM_CID
1411 IUPHAR_LIGAND_ID
102750006 SNOMEDCT_US
006741 NDDF

Pharmaceutical products:

None