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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
dexfosfoserine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives
4120
407-41-0
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
phosphoserine
dexfosfoserine
fosforina
3-O-Phosphoserine
L-Phosphoserine
seriphos
L-serine-O-phosphate
L-SOP
The phosphoric acid ester of serine.
Molecular weight: 185.07
Formula: C3H8NO6P
CLOGP: -4.46
LIPINSKI: 0
HAC: 7
HDO: 4
TPSA: 130.08
ALOGS: -0.97
ROTB: 4
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:62089
glutamate synthase inhibitors
CHEBI has role
CHEBI:75771
Mus musculus metabolites
CHEBI has role
CHEBI:75772
S. cerevisiae metabolites
CHEBI has role
CHEBI:76971
Escherichia coli metabolites
CHEBI has role
CHEBI:77089
O-acetyl-L-homoserine sulfhydrolase inhibitor
CHEBI has role
CHEBI:77090
L-serine-O-sulfate ammonia-lyase (pyruvate-forming) inhibitors
CHEBI has role
CHEBI:77746
Homo sapiens metabolite
Showing 1 to 7 of 7 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
0.95
acidic
pKa2
1.56
acidic
pKa3
6.29
acidic
pKa4
9.68
Basic
Showing 1 to 4 of 4 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Metabotropic glutamate receptor 4
GPCR
Q14833
GRM4_HUMAN
EC50
6
CHEMBL
Metabotropic glutamate receptor 7
GPCR
Q14831
GRM7_HUMAN
AGONIST
EC50
4.50
IUPHAR
Metabotropic glutamate receptor 6
GPCR
O15303
GRM6_HUMAN
AGONIST
EC50
6.40
IUPHAR
Metabotropic glutamate receptor 8
GPCR
O00222
GRM8_HUMAN
AGONIST
IC50
7.20
IUPHAR
Metabotropic glutamate receptor 4
GPCR
GRM4_RAT
EC50
5.40
CHEMBL
Metabotropic glutamate receptor 6
GPCR
GRM6_RAT
EC50
5.57
CHEMBL
Showing 1 to 6 of 6 entries
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External reference:
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ID
Source
SEP
PDB_CHEM_ID
006741
NDDF
102750006
SNOMEDCT_US
1411
IUPHAR_LIGAND_ID
68841
PUBCHEM_CID
6888
INN_ID
C5418344
UMLSCUI
CHEBI:15811
CHEBI
CHEMBL284377
ChEMBL_ID
D010768
MESH_DESCRIPTOR_UI
Showing 1 to 10 of 12 entries
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Pharmaceutical products:
None
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dexfosfoserine