dexfosfoserine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives	4120	407-41-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phosphoserine
dexfosfoserine
fosforina
3-O-Phosphoserine
L-Phosphoserine
seriphos
L-serine-O-phosphate
L-SOP

The phosphoric acid ester of serine.

Molecular weight: 185.07
Formula: C3H8NO6P
CLOGP: -4.46
LIPINSKI: 0
HAC: 7
HDO: 4
TPSA: 130.08
ALOGS: -0.97
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:62089	glutamate synthase inhibitors
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77089	O-acetyl-L-homoserine sulfhydrolase inhibitor
CHEBI has role	CHEBI:77090	L-serine-O-sulfate ammonia-lyase (pyruvate-forming) inhibitors
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	0.95	acidic
pKa2	1.56	acidic
pKa3	6.29	acidic
pKa4	9.68	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Metabotropic glutamate receptor 4	GPCR	Q14833	GRM4_HUMAN		EC50	6		CHEMBL
Metabotropic glutamate receptor 7	GPCR	Q14831	GRM7_HUMAN	AGONIST	EC50	4.50		IUPHAR
Metabotropic glutamate receptor 6	GPCR	O15303	GRM6_HUMAN	AGONIST	EC50	6.40		IUPHAR
Metabotropic glutamate receptor 8	GPCR	O00222	GRM8_HUMAN	AGONIST	IC50	7.20		IUPHAR
Metabotropic glutamate receptor 4	GPCR		GRM4_RAT		EC50	5.40		CHEMBL
Metabotropic glutamate receptor 6	GPCR		GRM6_RAT		EC50	5.57		CHEMBL

External reference:

ID	Source
C5418344	UMLSCUI
CHEBI:15811	CHEBI
SEP	PDB_CHEM_ID
CHEMBL284377	ChEMBL_ID
DB04522	DRUGBANK_ID
6888	INN_ID
VI4F0K069V	UNII
68841	PUBCHEM_CID
006741	NDDF
102750006	SNOMEDCT_US
D010768	MESH_DESCRIPTOR_UI
1411	IUPHAR_LIGAND_ID

Pharmaceutical products:

None