razoxane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
benzodioxane derivatives 4031 21416-67-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • razoxane mesylate
  • razoxane
  • razoxin
  • tepirone
  • troxozone
An antimitotic agent with immunosuppressive properties.
  • Molecular weight: 268.27
  • Formula: C11H16N4O4
  • CLOGP: -1.33
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 98.82
  • ALOGS: -1.41
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D050256 Antimitotic Agents
MeSH PA D000970 Antineoplastic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Doxorubicin Induced Cardiomyopathy indication
Extravasation Injury from Anthracycline Injection indication
Impaired renal function disorder contraindication 197663003
Bone marrow depression contraindication 307762000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.61 acidic
pKa2 10.22 acidic
pKa3 6.83 Basic
pKa4 2.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000006134 NUI
D08471 KEGG_DRUG
C0034738 UMLSCUI
CHEBI:50225 CHEBI
CHEMBL444186 ChEMBL_ID
D011929 MESH_DESCRIPTOR_UI
30623 PUBCHEM_CID
3675 INN_ID
5AR83PR647 UNII
196454 RXNORM
004030 NDDF
387518009 SNOMEDCT_US
90346006 SNOMEDCT_US

Pharmaceutical products:

None