propylene glycol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4024 57-55-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propane-1,2-diol
  • 1,2-propanediol
  • 1,2-propylene glycol
  • propylene glycol
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
  • Molecular weight: 76.10
  • Formula: C3H8O2
  • CLOGP: -1.06
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: 1.10
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PIK3CD,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 39
kinase-selectivity-class ACVRL1,AXL,BMX,BRAF,CDK1,CDK2,CDK4,CDK6,CDK7,CDK9,CHUK,DYRK1A,INSR,IRAK1,IRAK3,IRAK4,KIT,MAP2K6,MAP3K21,PDK1,PIK3CD,TGFBR1,ZAP70 23
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 852.50 12.88 350 27632 37620 90562845
Febrile neutropenia 475.02 12.88 392 27590 157957 90442508
Chronic sinusitis 371.83 12.88 170 27812 23632 90576833
Paraesthesia oral 300.24 12.88 161 27821 31498 90568967
Vaginal flatulence 285.01 12.88 117 27865 12521 90587944
Constipation 273.20 12.88 382 27600 280013 90320452
Proctitis 263.77 12.88 117 27865 15142 90585323
Sedation complication 258.27 12.88 119 27863 16825 90583640
Creatinine renal clearance decreased 254.97 12.88 122 27860 18777 90581688
Female genital tract fistula 252.23 12.88 119 27863 17749 90582716
Radiculopathy 245.23 12.88 118 27864 18387 90582078
Procedural pain 241.17 12.88 142 27840 33218 90567247
Vaginal discharge 239.56 12.88 118 27864 19346 90581119
Orthostatic hypotension 209.26 12.88 141 27841 41686 90558779
Blood calcium decreased 206.50 12.88 124 27858 30058 90570407
Aplastic anaemia 204.75 12.88 94 27888 13175 90587290
Colitis 186.40 12.88 162 27820 69780 90530685
Oral candidiasis 176.10 12.88 119 27863 35336 90565129
Sedation 162.62 12.88 128 27854 48043 90552422
Cognitive disorder 148.22 12.88 142 27840 69265 90531200
Depressed level of consciousness 142.51 12.88 142 27840 72642 90527823
Frequent bowel movements 141.93 12.88 127 27855 56808 90543657
Haematochezia 138.20 12.88 138 27844 70775 90529690
Colitis ulcerative 126.22 12.88 122 27860 60144 90540321
Renal function test abnormal 120.60 12.88 54 27928 7137 90593328
Creatinine renal clearance increased 115.48 12.88 42 27940 3239 90597226
Rectal haemorrhage 112.18 12.88 133 27849 82611 90517854
Therapeutic product effect incomplete 108.82 12.88 206 27776 193690 90406775
Balance disorder 107.52 12.88 141 27841 96939 90503526
Hypotension 99.90 12.88 272 27710 325125 90275340
Abdominal pain 96.80 12.88 305 27677 395416 90205049
Systemic lupus erythematosus 94.63 12.88 4 27978 361892 90238573
Glossodynia 86.02 12.88 3 27979 321776 90278689
Eye irritation 85.07 12.88 76 27906 33902 90566563
Arthropathy 84.09 12.88 8 27974 366234 90234231
Drug intolerance 81.75 12.88 19 27963 447572 90152893
Joint swelling 76.34 12.88 30 27952 503270 90097195
Anaemia 69.50 12.88 253 27729 352549 90247916
Weight decreased 68.67 12.88 265 27717 379645 90220820
Multiple drug therapy 67.40 12.88 36 27946 6973 90593492
Dyspepsia 67.19 12.88 172 27810 197988 90402477
Eye pain 64.86 12.88 74 27908 44094 90556371
Abdominal discomfort 62.29 12.88 35 27947 477293 90123172
Erythema 61.84 12.88 183 27799 229063 90371402
Transfusion 60.13 12.88 47 27935 17441 90583024
Treatment failure 59.38 12.88 11 27971 303917 90296548
Pericarditis 59.17 12.88 7 27975 270144 90330321
Rash 58.08 12.88 98 27884 796002 89804463
Swelling 57.20 12.88 29 27953 419029 90181436
Therapeutic product effect decreased 56.52 12.88 9 27973 277562 90322903
Maternal exposure during pregnancy 55.32 12.88 21 27961 360042 90240423
Alopecia 54.28 12.88 44 27938 495027 90105438
Fall 52.71 12.88 290 27692 481520 90118945
Hepatic enzyme increased 52.24 12.88 23 27959 360713 90239752
Toxicity to various agents 50.50 12.88 199 27783 287647 90312818
Foreign body sensation in eyes 49.71 12.88 23 27959 3277 90597188
Rheumatoid arthritis 49.61 12.88 25 27957 362589 90237876
Pyrexia 49.54 12.88 361 27621 660124 89940341
Wound 49.40 12.88 16 27966 302964 90297501
Nasopharyngitis 48.72 12.88 33 27949 407071 90193394
Hypersensitivity 47.88 12.88 42 27940 454635 90145830
Arthralgia 47.09 12.88 107 27875 778415 89822050
Fibromyalgia 46.03 12.88 5 27977 206264 90394201
Product use issue 44.75 12.88 23 27959 329896 90270569
Pneumonia viral 44.71 12.88 30 27952 8793 90591672
Impaired healing 44.63 12.88 9 27973 234190 90366275
Psoriatic arthropathy 43.04 12.88 9 27973 228326 90372139
Instillation site pain 40.71 12.88 14 27968 916 90599549
Discomfort 40.48 12.88 17 27965 274318 90326147
Ill-defined disorder 39.96 12.88 5 27977 184886 90415579
Exposure during pregnancy 39.91 12.88 12 27970 238398 90362067
Condition aggravated 39.19 12.88 78 27904 595467 90004998
Drug hypersensitivity 38.64 12.88 52 27930 463557 90136908
Breath sounds abnormal 37.68 12.88 34 27948 15352 90585113
Peripheral swelling 36.84 12.88 44 27938 413062 90187403
Presyncope 36.43 12.88 47 27935 31758 90568707
Upper gastrointestinal haemorrhage 36.30 12.88 40 27942 22936 90577529
Musculoskeletal stiffness 34.18 12.88 25 27957 296507 90303958
Infective pulmonary exacerbation of cystic fibrosis 33.99 12.88 27 27955 10252 90590213
Nausea 32.36 12.88 501 27481 1109815 89490650
Clostridium test positive 31.36 12.88 20 27962 5381 90595084
Type 2 diabetes mellitus 30.95 12.88 12 27970 203232 90397233
Blister 30.04 12.88 21 27961 254977 90345488
Infection 29.76 12.88 41 27941 362053 90238412
Blood cholesterol increased 28.94 12.88 14 27968 207998 90392467
Completed suicide 28.85 12.88 5 27977 145053 90455412
Fatigue 28.66 12.88 224 27758 1153799 89446666
Liver injury 27.80 12.88 9 27973 170558 90429907
Cardiac murmur 27.58 12.88 31 27951 18163 90582302
Intentional product use issue 26.71 12.88 17 27965 216875 90383590
Erythema of eyelid 26.44 12.88 15 27967 3268 90597197
Mucosal inflammation 26.03 12.88 56 27926 57569 90542896
Eye discharge 25.84 12.88 21 27961 8237 90592228
Nasal congestion 25.78 12.88 70 27912 83344 90517121
Ocular hyperaemia 25.56 12.88 41 27941 33757 90566708
Cytokine release syndrome 25.48 12.88 37 27945 27936 90572529
Bursitis 25.19 12.88 5 27977 131649 90468816
Eosinophilia 24.92 12.88 37 27945 28496 90571969
Inflammation 24.88 12.88 12 27970 178580 90421885
Mental status changes 24.43 12.88 47 27935 44632 90555833
Urticaria 24.13 12.88 37 27945 312697 90287768
Electrocardiogram ST segment elevation 23.64 12.88 15 27967 4001 90596464
Sinusitis 23.34 12.88 44 27938 343044 90257421
Weight increased 23.18 12.88 60 27922 417867 90182598
Stomatitis 22.67 12.88 31 27951 274667 90325798
Bacteraemia 22.54 12.88 31 27951 22269 90578196
Pain 21.57 12.88 429 27553 995912 89604553
Unmasking of previously unidentified disease 21.34 12.88 10 27972 1466 90598999
Respiratory distress 21.33 12.88 41 27941 38905 90561560
Salivary gland enlargement 21.28 12.88 7 27975 399 90600066
Hypercholesterolaemia 21.14 12.88 3 27979 100889 90499576
Injury 21.02 12.88 18 27964 197331 90403134
Escherichia bacteraemia 20.99 12.88 16 27966 5719 90594746
Hyponatraemia 20.75 12.88 89 27893 133449 90467016
Platelet transfusion 20.68 12.88 9 27973 1111 90599354
Psoriasis 20.47 12.88 10 27972 147744 90452721
Pruritus 20.34 12.88 92 27890 541433 90059032
Musculoskeletal pain 20.30 12.88 14 27968 171237 90429228
Pustule 20.11 12.88 12 27970 2871 90597594
Respiratory failure 20.03 12.88 81 27901 118337 90482128
Malaise 19.56 12.88 271 27711 585715 90014750
Electrocardiogram QRS complex prolonged 19.51 12.88 17 27965 7331 90593134
General physical health deterioration 18.91 12.88 52 27930 355063 90245402
Electrocardiogram repolarisation abnormality 18.91 12.88 9 27973 1367 90599098
Scleral hyperaemia 18.81 12.88 6 27976 310 90600155
Pulmonary fibrosis 18.74 12.88 5 27977 107498 90492967
Hypoaesthesia 18.28 12.88 44 27938 314166 90286299
Dementia 18.11 12.88 29 27953 23832 90576633
Sleep disorder 17.73 12.88 21 27961 198009 90402456
Atrial enlargement 17.71 12.88 6 27976 375 90600090
Fibula agenesis 17.45 12.88 4 27978 57 90600408
Spina bifida occulta 17.39 12.88 4 27978 58 90600407
Contusion 17.27 12.88 32 27950 251184 90349281
Bacterial translocation 17.04 12.88 7 27975 749 90599716
Hypertension 17.01 12.88 78 27904 457454 90143011
Mobility decreased 16.99 12.88 134 27848 250600 90349865
Eyelid pain 16.80 12.88 7 27975 776 90599689
Lacrimation increased 16.71 12.88 30 27952 27032 90573433
Wound infection 16.66 12.88 6 27976 106396 90494069
Acute respiratory failure 16.36 12.88 39 27943 42879 90557586
Loss of personal independence in daily activities 16.30 12.88 11 27971 136094 90464371
Rhinovirus infection 16.25 12.88 14 27968 5949 90594516
Migraine 16.19 12.88 21 27961 190371 90410094
Prescribed overdose 16.17 12.88 5 27977 97620 90502845
Systolic dysfunction 16.15 12.88 9 27973 1895 90598570
Oedema 16.12 12.88 23 27959 200272 90400193
Hypoxia 16.00 12.88 54 27928 72345 90528120
Night sweats 15.97 12.88 10 27972 128756 90471709
Cardiomyopathy 15.95 12.88 25 27957 20181 90580284
Eyelids pruritus 15.89 12.88 9 27973 1955 90598510
Failure to thrive 15.69 12.88 16 27966 8395 90592070
Gastrointestinal disorder 15.68 12.88 35 27947 256652 90343813
Enterovirus infection 15.39 12.88 8 27974 1466 90598999
Chronic obstructive pulmonary disease 15.38 12.88 54 27928 73775 90526690
Neutrophil count increased 15.32 12.88 24 27958 19366 90581099
Tricuspid valve disease 15.22 12.88 5 27977 284 90600181
Acidosis 14.87 12.88 19 27963 12717 90587748
Mouth swelling 14.83 12.88 13 27969 5649 90594816
Autoimmune disorder 14.50 12.88 3 27979 76741 90523724
Dry eye 14.42 12.88 45 27937 57886 90542579
Anaemia vitamin B12 deficiency 14.40 12.88 6 27976 666 90599799
Hip arthroplasty 14.36 12.88 3 27979 76205 90524260
Osteoarthritis 14.29 12.88 24 27958 195706 90404759
Red blood cell sedimentation rate increased 14.10 12.88 4 27978 82591 90517874
Bladder disorder 14.06 12.88 17 27965 10755 90589710
Eye pruritus 14.02 12.88 29 27953 28998 90571467
Gastric ulcer 13.95 12.88 28 27954 27420 90573045
Drug ineffective 13.91 12.88 540 27442 1383758 89216707
Gait inability 13.68 12.88 15 27967 146441 90454024
Photophobia 13.68 12.88 24 27958 21245 90579220
Intentional overdose 13.53 12.88 6 27976 93828 90506637
C-reactive protein increased 13.47 12.88 22 27960 181367 90419098
Circulatory collapse 13.37 12.88 26 27956 24878 90575587
Corneal infiltrates 13.36 12.88 4 27978 167 90600298
Abnormal sensation in eye 13.22 12.88 8 27974 1963 90598502
Vision blurred 13.10 12.88 68 27914 110225 90490240
Pulmonary embolism 13.10 12.88 77 27905 130743 90469722
Injection site pain 12.96 12.88 21 27961 173678 90426787

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 389.74 12.63 447 18727 185256 42416905
Aplastic anaemia 166.16 12.63 90 19084 12294 42589867
Appendicolith 122.47 12.63 76 19098 13380 42588781
Appendicitis 103.96 12.63 81 19093 20532 42581629
Myasthenia gravis 93.73 12.63 69 19105 16068 42586093
Blood phosphorus increased 80.61 12.63 57 19117 12468 42589693
Ventricular fibrillation 77.50 12.63 81 19093 30042 42572119
Hyperphosphataemia 71.93 12.63 54 19120 12950 42589211
Hypophosphataemia 64.31 12.63 62 19112 20883 42581278
Blood uric acid increased 63.42 12.63 54 19120 15493 42586668
Abdominal distension 62.32 12.63 114 19060 71621 42530540
Ocular procedural complication 62.02 12.63 12 19162 44 42602117
Ascites 59.58 12.63 98 19076 56580 42545581
Hyponatraemia 56.16 12.63 134 19040 101328 42500833
Stress 55.57 12.63 83 19091 44129 42558032
Cardiogenic shock 55.30 12.63 74 19100 35566 42566595
Sepsis 52.87 12.63 203 18971 199131 42403030
Neuralgia 52.18 12.63 61 19113 25586 42576575
Analgesic therapy 49.81 12.63 33 19141 6491 42595670
Sleep disorder therapy 48.16 12.63 33 19141 6861 42595300
Clostridium test positive 44.85 12.63 29 19145 5476 42596685
Incorrect route of product administration 44.84 12.63 55 19119 24250 42577911
Drug therapy 43.29 12.63 30 19144 6350 42595811
Cytokine release syndrome 42.81 12.63 74 19100 44453 42557708
Iron deficiency 42.24 12.63 37 19137 11024 42591137
Blood cholesterol increased 42.21 12.63 56 19118 26685 42575476
Dry mouth 41.96 12.63 69 19105 39810 42562351
Abdominal pain 40.28 12.63 181 18993 190290 42411871
Drug ineffective 39.79 12.63 148 19026 630049 41972112
Bacterial infection 37.42 12.63 54 19120 27825 42574336
Injection related reaction 37.31 12.63 13 19161 603 42601558
Multiple organ dysfunction syndrome 36.36 12.63 111 19063 96924 42505237
Mucosal inflammation 33.78 12.63 71 19103 49303 42552858
Aspiration 32.22 12.63 40 19134 17846 42584315
Infective pulmonary exacerbation of cystic fibrosis 31.56 12.63 27 19147 7791 42594370
Constipation 31.17 12.63 150 19024 162141 42440020
General physical health deterioration 30.66 12.63 142 19032 151104 42451057
Platelet transfusion 30.46 12.63 15 19159 1679 42600482
Diabetes mellitus 29.66 12.63 76 19098 60011 42542150
Activated partial thromboplastin time prolonged 27.74 12.63 35 19139 15868 42586293
Anticoagulant therapy 27.70 12.63 20 19154 4515 42597646
Enterococcus test positive 27.59 12.63 14 19160 1671 42600490
Thrombosis 27.19 12.63 80 19094 68431 42533730
Antacid therapy 27.00 12.63 20 19154 4697 42597464
Bacteraemia 25.89 12.63 43 19131 24997 42577164
Blood calcium increased 25.89 12.63 25 19149 8429 42593732
Pseudomonal bacteraemia 25.58 12.63 15 19159 2381 42599780
Cerebral artery thrombosis 25.30 12.63 12 19162 1237 42600924
Bacteroides infection 24.51 12.63 15 19159 2572 42599589
Intentional product misuse 24.29 12.63 72 19102 61828 42540333
Swelling 23.63 12.63 66 19108 54819 42547342
End stage renal disease 23.58 12.63 33 19141 16525 42585636
Chronic obstructive pulmonary disease 23.44 12.63 72 19102 63042 42539119
Sleep disorder 22.87 12.63 60 19114 48035 42554126
Total lung capacity decreased 22.39 12.63 16 19158 3554 42598607
Brain scan abnormal 22.37 12.63 11 19163 1228 42600933
Ulcer 22.28 12.63 32 19142 16409 42585752
Urinary tract infection pseudomonal 21.70 12.63 11 19163 1310 42600851
Aortic stenosis 21.56 12.63 23 19151 8722 42593439
Transfusion 21.37 12.63 25 19149 10489 42591672
Bronchopulmonary aspergillosis allergic 20.88 12.63 17 19157 4581 42597580
Therapeutic product effect incomplete 19.63 12.63 4 19170 70935 42531226
Pneumonia aspiration 19.41 12.63 58 19116 50020 42552141
Vomiting 19.25 12.63 207 18967 289516 42312645
Blood test abnormal 18.80 12.63 26 19148 12880 42589281
Oesophageal injury 18.76 12.63 6 19168 213 42601948
Troponin increased 18.73 12.63 32 19142 19030 42583131
Respiratory distress 18.70 12.63 51 19123 41769 42560392
Reaction to excipient 18.63 12.63 8 19166 654 42601507
Keratitis 18.56 12.63 11 19163 1780 42600381
Congenital hiatus hernia 18.42 12.63 18 19156 6156 42596005
Drug hypersensitivity 17.73 12.63 90 19084 99299 42502862
Lung opacity 17.38 12.63 17 19157 5820 42596341
Volvulus 17.38 12.63 11 19163 2002 42600159
Hyperlipidaemia 17.17 12.63 33 19141 21483 42580678
Chylothorax 17.05 12.63 9 19165 1165 42600996
Interstitial lung disease 16.99 12.63 7 19167 78455 42523706
Gout 16.52 12.63 38 19136 28017 42574144
Skin reaction 16.39 12.63 18 19156 7049 42595112
Gastrointestinal necrosis 16.14 12.63 14 19160 4114 42598047
Rash 15.50 12.63 68 19106 276886 42325275
Alpha haemolytic streptococcal infection 15.44 12.63 10 19164 1892 42600269
Corneal opacity 15.37 12.63 7 19167 658 42601503
Arthralgia 15.05 12.63 45 19129 205193 42396968
Corneal epithelium defect 14.91 12.63 6 19168 416 42601745
Myalgia 14.63 12.63 13 19161 96067 42506094
Intentional product use issue 14.63 12.63 7 19167 71826 42530335
Victim of child abuse 14.18 12.63 8 19166 1181 42600980
Orthostatic hypertension 14.14 12.63 6 19168 476 42601685
Intestinal pseudo-obstruction 13.90 12.63 10 19164 2245 42599916
Mucosal infection 13.89 12.63 5 19169 255 42601906
Somnolence 13.46 12.63 109 19065 140996 42461165
Areflexia 13.25 12.63 12 19162 3731 42598430
Pleuritic pain 13.02 12.63 16 19158 7061 42595100
Faecaloma 12.89 12.63 15 19159 6255 42595906
Gastroenteritis 12.84 12.63 25 19149 16424 42585737

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 879.75 12.38 820 41195 315947 110231337
Aplastic anaemia 376.11 12.38 184 41831 24124 110523160
Chronic sinusitis 321.04 12.38 167 41848 24917 110522367
Macular degeneration 317.38 12.38 158 41857 21501 110525783
Constipation 268.03 12.38 484 41531 357302 110189982
Vaginal flatulence 262.81 12.38 116 41899 12028 110535256
Paraesthesia oral 257.26 12.38 160 41855 33511 110513773
Proctitis 237.75 12.38 120 41895 16807 110530477
Female genital tract fistula 234.63 12.38 118 41897 16401 110530883
Sedation complication 225.27 12.38 122 41893 19733 110527551
Vaginal discharge 222.78 12.38 117 41898 17791 110529493
Radiculopathy 222.70 12.38 120 41895 19216 110528068
Creatinine renal clearance decreased 222.64 12.38 125 41890 21690 110525594
Procedural pain 205.73 12.38 142 41873 35423 110511861
Blood calcium decreased 186.17 12.38 134 41881 35711 110511573
Orthostatic hypotension 159.46 12.38 159 41856 66090 110481194
Oral candidiasis 145.50 12.38 127 41888 44633 110502651
Colitis 133.45 12.38 179 41836 102144 110445140
Appendicolith 132.87 12.38 77 41938 14178 110533106
Cognitive disorder 118.59 12.38 156 41859 87355 110459929
Abdominal pain 118.04 12.38 445 41570 512544 110034740
Sedation 106.68 12.38 132 41883 69551 110477733
Creatinine renal clearance increased 102.94 12.38 42 41973 3583 110543701
Frequent bowel movements 99.42 12.38 129 41886 71261 110476023
Appendicitis 99.08 12.38 84 41931 28380 110518904
Renal function test abnormal 98.77 12.38 54 41961 8892 110538392
Myasthenia gravis 90.72 12.38 71 41944 21440 110525844
Colitis ulcerative 89.84 12.38 128 41887 77235 110470049
Depressed level of consciousness 89.09 12.38 156 41859 112122 110435162
Ventricular fibrillation 88.23 12.38 93 41922 41220 110506064
Balance disorder 86.14 12.38 157 41858 116403 110430881
Blood phosphorus increased 82.35 12.38 60 41955 16280 110531004
Arthropathy 80.45 12.38 8 42007 287514 110259770
Joint swelling 78.51 12.38 35 41980 442810 110104474
Contraindicated product administered 77.78 12.38 4 42011 248263 110299021
Haematochezia 77.14 12.38 149 41866 115375 110431909
Transfusion 76.26 12.38 69 41946 25403 110521881
Hyponatraemia 75.27 12.38 217 41798 217436 110329848
Clostridium test positive 73.80 12.38 48 41967 10845 110536439
Hyperphosphataemia 73.29 12.38 56 41959 16325 110530959
Cytokine release syndrome 72.49 12.38 110 41905 70196 110477088
Glossodynia 71.41 12.38 3 42012 222001 110325283
Arthralgia 69.06 12.38 119 41896 779513 109767771
Blood uric acid increased 67.78 12.38 60 41955 21469 110525815
Rectal haemorrhage 67.46 12.38 144 41871 119689 110427595
Rheumatoid arthritis 64.62 12.38 17 41998 299596 110247688
Sepsis 63.92 12.38 270 41745 327076 110220208
Multiple drug therapy 63.52 12.38 39 41976 7975 110539309
Mucosal inflammation 62.96 12.38 123 41892 96018 110451266
Maternal exposure during pregnancy 62.00 12.38 11 42004 254872 110292412
Hypotension 61.96 12.38 375 41640 523474 110023810
Anaemia 61.80 12.38 387 41628 546699 110000585
Hypophosphataemia 60.94 12.38 69 41946 33113 110514171
Rash 60.92 12.38 139 41876 820825 109726459
Therapeutic product effect decreased 60.62 12.38 10 42005 244306 110302978
Therapeutic product effect incomplete 59.73 12.38 204 41811 223601 110323683
Treatment failure 59.27 12.38 16 41999 277218 110270066
Nasopharyngitis 57.15 12.38 40 41975 394321 110152963
Abdominal discomfort 57.01 12.38 40 41975 393818 110153466
Ascites 56.29 12.38 115 41900 92693 110454591
Ocular procedural complication 54.30 12.38 16 41999 511 110546773
Analgesic therapy 54.07 12.38 34 41981 7250 110540034
Bacteraemia 53.47 12.38 73 41942 42317 110504967
Sleep disorder therapy 53.28 12.38 34 41981 7437 110539847
Fibromyalgia 52.75 12.38 3 42012 170906 110376378
Hypersensitivity 51.00 12.38 47 41968 403951 110143333
Irritable bowel syndrome 50.33 12.38 3 42012 164212 110383072
Alopecia 50.25 12.38 39 41976 364714 110182570
Infective pulmonary exacerbation of cystic fibrosis 50.19 12.38 43 41972 14728 110532556
Pericarditis 50.05 12.38 11 42004 219103 110328181
Wound 49.23 12.38 14 42001 234423 110312861
Psoriatic arthropathy 48.93 12.38 8 42007 196753 110350531
Cardiogenic shock 48.52 12.38 82 41933 57256 110490028
Intentional product use issue 48.15 12.38 17 41998 247889 110299395
Inflammation 47.73 12.38 8 42007 193230 110354054
Pyrexia 47.25 12.38 535 41480 897730 109649554
Chronic obstructive pulmonary disease 46.93 12.38 118 41897 109040 110438244
Impaired healing 46.74 12.38 9 42006 196708 110350576
Drug therapy 46.65 12.38 31 41984 7260 110540024
Hepatic enzyme increased 45.88 12.38 33 41982 320859 110226425
Dyspepsia 45.73 12.38 168 41847 190797 110356487
Platelet transfusion 45.37 12.38 22 41993 2824 110544460
Neuralgia 44.61 12.38 72 41943 48406 110498878
Eye irritation 44.31 12.38 59 41956 33393 110513891
Ill-defined disorder 42.24 12.38 5 42010 156848 110390436
Peripheral swelling 39.16 12.38 58 41957 403976 110143308
Exposure during pregnancy 39.06 12.38 8 42007 167416 110379868
Pneumonia viral 38.97 12.38 33 41982 11124 110536160
Breath sounds abnormal 38.67 12.38 48 41967 25356 110521928
Fall 37.56 12.38 372 41643 603110 109944174
Completed suicide 37.24 12.38 23 41992 242358 110304926
Erythema 37.20 12.38 213 41802 291234 110256050
Iron deficiency 36.64 12.38 40 41975 18436 110528848
Abdominal distension 36.15 12.38 147 41868 174956 110372328
Respiratory distress 35.61 12.38 80 41935 68794 110478490
Bursitis 35.33 12.38 4 42011 129914 110417370
Type 2 diabetes mellitus 34.67 12.38 12 42003 177220 110370064
Blister 34.34 12.38 22 41993 227354 110319930
Bacterial infection 33.98 12.38 62 41953 45974 110501310
Upper gastrointestinal haemorrhage 33.89 12.38 65 41950 50031 110497253
Fatigue 33.65 12.38 298 41717 1215660 109331624
Infection 33.18 12.38 54 41961 362146 110185138
Joint range of motion decreased 32.51 12.38 4 42011 121828 110425456
Liver injury 31.54 12.38 9 42006 150404 110396880
Activated partial thromboplastin time prolonged 30.47 12.38 40 41975 22328 110524956
Psoriasis 30.06 12.38 8 42007 139985 110407299
Anticoagulant therapy 30.04 12.38 21 41994 5340 110541944
Antacid therapy 29.61 12.38 21 41994 5463 110541821
Weight increased 29.50 12.38 73 41942 419571 110127713
Discomfort 29.50 12.38 23 41992 214684 110332600
Weight decreased 29.32 12.38 289 41726 467768 110079516
Aspiration 28.99 12.38 46 41969 30487 110516797
Nausea 28.45 12.38 641 41374 1235049 109312235
Contusion 28.43 12.38 28 41987 233333 110313951
Foreign body sensation in eyes 28.42 12.38 17 41998 3317 110543967
Multiple organ dysfunction syndrome 27.92 12.38 123 41892 151587 110395697
Enterococcus test positive 27.90 12.38 16 41999 2888 110544396
Rhinovirus infection 27.81 12.38 28 41987 11761 110535523
Injection related reaction 27.60 12.38 13 42002 1565 110545719
Escherichia bacteraemia 27.45 12.38 26 41989 10138 110537146
Lip dry 27.42 12.38 3 42012 100080 110447204
Reaction to excipient 27.17 12.38 14 42001 2045 110545239
Troponin increased 27.10 12.38 44 41971 29722 110517562
Sinusitis 26.45 12.38 45 41970 296643 110250641
Stress 26.32 12.38 94 41921 105254 110442030
Pulmonary embolism 26.22 12.38 155 41860 214319 110332965
Injury 25.63 12.38 18 41997 177247 110370037
Thrombosis 25.49 12.38 95 41920 108567 110438717
Drug intolerance 25.34 12.38 75 41940 406437 110140847
Bacteroides infection 25.18 12.38 15 42000 2904 110544380
Volvulus 25.06 12.38 16 41999 3502 110543782
Eye pain 24.57 12.38 57 41958 50042 110497242
Failure to thrive 24.54 12.38 28 41987 13546 110533738
Injection site pain 24.51 12.38 19 41996 177903 110369381
Intentional overdose 24.20 12.38 10 42005 132491 110414793
Keratitis 23.92 12.38 18 41997 5126 110542158
Condition aggravated 23.52 12.38 173 41842 734663 109812621
Incorrect route of product administration 23.21 12.38 65 41950 63996 110483288
Respiratory failure 22.80 12.38 150 41865 215182 110332102
End stage renal disease 22.70 12.38 34 41981 21439 110525845
Mental status changes 22.62 12.38 72 41943 76050 110471234
Hypoaesthesia 22.59 12.38 54 41961 314169 110233115
Instillation site pain 22.41 12.38 9 42006 737 110546547
Alpha haemolytic streptococcal infection 22.32 12.38 15 42000 3578 110543706
Musculoskeletal pain 22.24 12.38 22 41993 183001 110364283
Osteoarthritis 22.14 12.38 22 41993 182601 110364683
Paraesthesia 21.95 12.38 45 41970 276476 110270808
Pseudomonal bacteraemia 21.91 12.38 16 41999 4355 110542929
Brain scan abnormal 21.65 12.38 11 42004 1560 110545724
Migraine 21.60 12.38 20 41995 171632 110375652
Cerebral artery thrombosis 21.03 12.38 11 42004 1657 110545627
Congenital hiatus hernia 20.82 12.38 18 41997 6241 110541043
Loss of personal independence in daily activities 20.69 12.38 16 41999 150004 110397280
Pain in extremity 20.63 12.38 105 41910 487013 110060271
Diabetes mellitus 20.16 12.38 83 41932 99298 110447986
Electrocardiogram repolarisation abnormality 20.15 12.38 12 42003 2323 110544961
Pruritus 20.03 12.38 134 41881 581426 109965858
Red blood cell sedimentation rate increased 19.87 12.38 3 42012 78299 110468985
Bronchopulmonary aspergillosis allergic 19.85 12.38 20 41995 8406 110538878
Acute respiratory failure 19.52 12.38 68 41947 75192 110472092
Gout 19.49 12.38 43 41972 36523 110510761
Hypoxia 19.45 12.38 99 41916 129416 110417868
Erythema of eyelid 18.88 12.38 14 42001 3901 110543383
Salivary gland enlargement 18.88 12.38 7 42008 462 110546822
Aortic stenosis 18.80 12.38 24 41991 13035 110534249
C-reactive protein increased 18.56 12.38 34 41981 217885 110329399
Sciatica 18.52 12.38 6 42009 92393 110454891
Grip strength decreased 18.35 12.38 4 42011 80170 110467114
Urticaria 18.33 12.38 61 41954 318796 110228488
Wound infection 18.07 12.38 7 42008 96458 110450826
Corneal opacity 17.95 12.38 9 42006 1242 110546042
Hyperlipidaemia 17.81 12.38 41 41974 35807 110511477
Myalgia 17.80 12.38 36 41979 222345 110324939
Blood phosphorus decreased 17.70 12.38 18 41997 7647 110539637
Product use issue 17.67 12.38 60 41955 311635 110235649
Oesophageal injury 17.65 12.38 6 42009 307 110546977
Night sweats 17.59 12.38 15 42000 133968 110413316
Drug ineffective 17.58 12.38 442 41573 1520098 109027186
Nasal congestion 17.56 12.38 79 41936 98203 110449081
Parenteral nutrition 17.56 12.38 8 42007 892 110546392
Corneal epithelium defect 17.46 12.38 8 42007 904 110546380
Clostridium difficile colitis 17.44 12.38 46 41969 43732 110503552
Arthritis 17.27 12.38 23 41992 167563 110379721
Musculoskeletal stiffness 17.16 12.38 52 41963 279770 110267514
Gait inability 17.03 12.38 16 41999 136360 110410924
Prescribed overdose 17.01 12.38 6 42009 87575 110459709
Total lung capacity decreased 16.97 12.38 17 41998 7097 110540187
Lymphocyte count decreased 16.87 12.38 54 41961 57189 110490095
Malnutrition 16.76 12.38 34 41981 27245 110520039
Road traffic accident 16.75 12.38 10 42005 107388 110439896
Dizziness 16.75 12.38 177 41838 698016 109849268
Depression 16.71 12.38 63 41952 317272 110230012
Pneumonia aspiration 16.60 12.38 68 41947 81165 110466119
Carbon dioxide decreased 16.56 12.38 14 42001 4710 110542574
Neutrophil count increased 16.53 12.38 39 41976 34613 110512671
Bacterial translocation 16.45 12.38 9 42006 1483 110545801
Intestinal pseudo-obstruction 16.18 12.38 12 42003 3344 110543940
Presyncope 16.16 12.38 48 41967 48839 110498445
Faecal vomiting 16.04 12.38 9 42006 1557 110545727
Hypophagia 15.84 12.38 50 41965 52576 110494708
Eye discharge 15.72 12.38 18 41997 8736 110538548
Pustule 15.72 12.38 12 42003 3492 110543792
Urinary tract infection pseudomonal 15.57 12.38 10 42005 2212 110545072
Blood calcium increased 15.52 12.38 26 41989 18014 110529270
Abdominal pain upper 15.49 12.38 74 41941 349037 110198247
Pain 15.40 12.38 473 41542 954482 109592802
Knee arthroplasty 15.36 12.38 3 42012 64945 110482339
Victim of child abuse 15.31 12.38 8 42007 1203 110546081
Oedema 15.15 12.38 36 41979 209940 110337344
Small intestinal obstruction 15.09 12.38 36 41979 32177 110515107
Mobility decreased 15.03 12.38 147 41868 237275 110310009
Memory impairment 14.83 12.38 33 41982 196911 110350373
Bronchiolitis 14.74 12.38 14 42001 5479 110541805
Lung opacity 14.59 12.38 20 41995 11632 110535652
Ocular hyperaemia 14.37 12.38 40 41975 39246 110508038
Endocrine ophthalmopathy 14.36 12.38 8 42007 1365 110545919
Injection site reaction 14.31 12.38 8 42007 89062 110458222
Corneal disorder 14.15 12.38 10 42005 2587 110544697
Vomiting 14.14 12.38 449 41566 910226 109637058
Hypogonadism 14.03 12.38 9 42006 1985 110545299
Encephalopathy 13.63 12.38 64 41951 80991 110466293
Unmasking of previously unidentified disease 13.26 12.38 10 42005 2858 110544426
Lower limb fracture 13.26 12.38 6 42009 75342 110471942
Sinus tachycardia 13.14 12.38 42 41973 44451 110502833
Proctitis bacterial 13.12 12.38 4 42011 144 110547140
Blood pressure fluctuation 13.10 12.38 6 42009 74818 110472466
Muscle spasms 12.91 12.38 58 41957 278099 110269185
Tracheostomy infection 12.78 12.38 4 42011 157 110547127
Benign prostatic hyperplasia 12.75 12.38 24 41991 18210 110529074
Pulmonary fibrosis 12.70 12.38 12 42003 102030 110445254
Ear infection 12.70 12.38 4 42011 62728 110484556
Drug resistance 12.53 12.38 3 42012 56371 110490913
Gastrointestinal necrosis 12.52 12.38 14 42001 6626 110540658
Ulcerative keratitis 12.51 12.38 12 42003 4754 110542530

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:48356 protic solvent
CHEBI has role CHEBI:50904 allergen
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:76967 human xenobiotic metabolite
MeSH PA D010592 Pharmaceutic Aids
MeSH PA D012997 Solvents
MeSH PA D014677 Pharmaceutical Vehicles
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:50503 laxative
CHEBI has role CHEBI:66981 ophthalmology drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tear film insufficiency indication 46152009
Keratoconjunctivitis sicca off-label use 302896008 DOID:12895




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017526 VUID
N0000145910 NUI
D00078 KEGG_DRUG
4017526 VANDF
C0072225 UMLSCUI
CHEBI:16997 CHEBI
CHEMBL286398 ChEMBL_ID
D019946 MESH_DESCRIPTOR_UI
DB01839 DRUGBANK_ID
6DC9Q167V3 UNII
1030 PUBCHEM_CID
34693 RXNORM
35450 MMSL
NOCODE MMSL
002468 NDDF
13668001 SNOMEDCT_US
411259004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Systane Lubricant HUMAN OTC DRUG LABEL 2 0065-0429 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane HUMAN OTC DRUG LABEL 2 0065-0431 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane HUMAN OTC DRUG LABEL 2 0065-0454 GEL 3 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane COMPLETE HUMAN OTC DRUG LABEL 1 0065-0481 EMULSION 0.06 mg OPHTHALMIC OTC Monograph Drug 12 sections
Systane Ultra HUMAN OTC DRUG LABEL 2 0065-1431 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 13 sections
SystaneULTRA HUMAN OTC DRUG LABEL 2 0065-1432 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 12 sections
Systane Balance HUMAN OTC DRUG LABEL 1 0065-1433 EMULSION 0.06 mg OPHTHALMIC OTC Monograph Drug 12 sections
SYSTANE HYDRATION PF PRESERVATIVE FREE HUMAN OTC DRUG LABEL 2 0065-1437 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane Ultra Preservative Free HUMAN OTC DRUG LABEL 2 0065-1507 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 12 sections
Systane COMPLETE PF HUMAN OTC DRUG LABEL 1 0065-1509 EMULSION 0.06 mg OPHTHALMIC OTC Monograph Drug 12 sections
SYSTANE HYDRATION PF PRESERVATIVE FREE HUMAN OTC DRUG LABEL 2 0065-1510 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane COMPLETE PF HUMAN OTC DRUG LABEL 1 0065-1530 EMULSION 0.06 mg OPHTHALMIC OTC Monograph Drug 12 sections
Systane Complete PF HUMAN OTC DRUG LABEL 1 0065-2509 EMULSION 0.06 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane Pro PF HUMAN OTC DRUG LABEL 1 0065-3290 EMULSION 6 mg OPHTHALMIC OTC Monograph Drug 13 sections
GenTeal Tears Gel Drops HUMAN OTC DRUG LABEL 2 0065-8067 GEL 3 mg OPHTHALMIC OTC Monograph Drug 13 sections
Systane Pro PF HUMAN OTC DRUG LABEL 1 0065-9308 EMULSION 6 mg OPHTHALMIC OTC Monograph Drug 13 sections
Walgreens Lubricant Eye Drops High Performance 15mL and twin pack HUMAN OTC DRUG LABEL 2 0363-4549 SOLUTION/ DROPS 0.30 g OPHTHALMIC OTC Monograph Drug 14 sections
Walgreens Lubricant Eye Drops Dry Eye 15mL and twin pack HUMAN OTC DRUG LABEL 2 0363-4551 SOLUTION/ DROPS 0.30 g OPHTHALMIC OTC Monograph Drug 13 sections
Walgreens Lubricant HUMAN OTC DRUG LABEL 2 0363-6153 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 12 sections
Walgreens Lubricant HUMAN OTC DRUG LABEL 2 0363-6153 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 12 sections
Walgreens Ultra Lubricant HUMAN OTC DRUG LABEL 2 0363-6154 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 12 sections
Walgreens Ultra Lubricant HUMAN OTC DRUG LABEL 2 0363-6154 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC Monograph Drug 12 sections
Lubricant Eye HUMAN OTC DRUG LABEL 2 0363-6451 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 13 sections
Walgreens Lubricant Eye Drops HUMAN OTC DRUG LABEL 2 0363-7220 SOLUTION/ DROPS 0.30 mg OPHTHALMIC OTC monograph final 11 sections
Walgreens Lubricant Eye HUMAN OTC DRUG LABEL 2 0363-7267 SOLUTION/ DROPS 3 mg OPHTHALMIC OTC monograph final 12 sections
Walgreen Sterile Lubricant HUMAN OTC DRUG LABEL 1 0363-7864 SOLUTION/ DROPS 0.06 mg OPHTHALMIC OTC monograph final 12 sections
Eye Lubricant HUMAN OTC DRUG LABEL 2 0363-8396 LIQUID 3 mg OPHTHALMIC OTC monograph final 12 sections
Rugby Lubricating Eye Drops HUMAN OTC DRUG LABEL 2 0536-1219 SOLUTION/ DROPS 0.30 g OPHTHALMIC OTC Monograph Drug 11 sections
Eyewash Station Additive Concentrate HUMAN OTC DRUG LABEL 2 0924-0159 LIQUID 280 kg OPHTHALMIC OTC Monograph Drug 14 sections
PhysiciansCare Eyewash Station Additive Concentrate HUMAN OTC DRUG LABEL 2 0924-0169 SOLUTION 280 kg OPHTHALMIC OTC monograph not final 10 sections