propylene glycol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4024	57-55-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: propane-1,2-diol 1,2-propanediol 1,2-propylene glycol propylene glycol	A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. Molecular weight: 76.10 Formula: C3H8O2 CLOGP: -1.06 LIPINSKI: 0 HAC: 2 HDO: 2 TPSA: 40.46 ALOGS: 1.10 ROTB: 1

Molecule

Description

Molfile Inchi Smiles

Synonyms:

propane-1,2-diol
1,2-propanediol
1,2-propylene glycol
propylene glycol

A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.

Molecular weight: 76.10
Formula: C3H8O2
CLOGP: -1.06
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: 1.10
ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Eye irritation	192.10	19.65	62	2993	21909	63464058
Eye pain	80.38	19.65	37	3018	33817	63452150
Foreign body sensation in eyes	79.49	19.65	19	3036	2215	63483752
Ocular hyperaemia	70.90	19.65	31	3024	25113	63460854
Pneumonia viral	63.64	19.65	21	3034	7901	63478066
Instillation site pain	61.17	19.65	13	3042	891	63485076
Breath sounds abnormal	60.66	19.65	22	3033	10951	63475016
Eye discharge	56.54	19.65	18	3037	6045	63479922
Cardiac murmur	51.19	19.65	21	3034	14531	63471436
Eye pruritus	49.33	19.65	22	3033	18649	63467318

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	142.25	31.79	42	2129	8559	34946201
Appendicitis	119.81	31.79	42	2129	14765	34939995
Ventricular fibrillation	101.90	31.79	42	2129	22912	34931848
Stress	100.10	31.79	45	2126	30302	34924458
Blood phosphorus increased	98.93	31.79	31	2140	7690	34947070
Cardiogenic shock	95.90	31.79	42	2129	26576	34928184
Myasthenia gravis	93.68	31.79	29	2142	6911	34947849
Ocular procedural complication	83.64	31.79	12	2159	55	34954705
Blood uric acid increased	80.48	31.79	28	2143	9596	34945164
Ascites	76.33	31.79	43	2128	46528	34908232

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	146.46	22.74	42	4437	8509	79731400
Eye irritation	120.94	22.74	45	4434	20636	79719273
Appendicitis	109.82	22.74	42	4437	20752	79719157
Blood phosphorus increased	96.96	22.74	32	4447	10315	79729594
Ventricular fibrillation	92.43	22.74	42	4437	31884	79708025
Myasthenia gravis	88.85	22.74	30	4449	10369	79729540
Ocular procedural complication	86.20	22.74	16	4463	465	79739444
Cardiogenic shock	84.46	22.74	43	4436	41871	79698038
Blood uric acid increased	77.82	22.74	29	4450	13331	79726578
Stress	65.89	22.74	46	4433	79566	79660343

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:48356	protogenic solvent
CHEBI has role	CHEBI:50904	alergeno
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76967	human xenobiotic metabolites
MeSH PA	D010592	Pharmaceutic Aids
MeSH PA	D014677	Pharmaceutical Vehicles
MeSH PA	D012997	Solvents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Tear film insufficiency	indication	46152009
Keratoconjunctivitis sicca	off-label use	302896008	DOID:12895

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
002468	NDDF
1030	PUBCHEM_CID
13668001	SNOMEDCT_US
34693	RXNORM
4017526	VUID
4017526	VANDF
411259004	SNOMEDCT_US
6DC9Q167V3	UNII
C0072225	UMLSCUI
CHEBI:16997	CHEBI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
GenTeal Tears Gel Drops	HUMAN OTC DRUG LABEL	2	0065-8067	GEL	3 mg	OPHTHALMIC	OTC monograph final	13 sections
Systane	HUMAN OTC DRUG LABEL	2	0065-0431	SOLUTION/ DROPS	3 mg	OPHTHALMIC	OTC monograph final	13 sections
Systane	HUMAN OTC DRUG LABEL	2	0065-0431	SOLUTION/ DROPS	3 mg	OPHTHALMIC	OTC monograph final	13 sections
Systane	HUMAN OTC DRUG LABEL	2	0065-0454	GEL	3 mg	OPHTHALMIC	OTC monograph final	13 sections
Systane	HUMAN OTC DRUG LABEL	2	0065-0454	GEL	3 mg	OPHTHALMIC	OTC monograph final	13 sections
Systane Balance	HUMAN OTC DRUG LABEL	1	0065-1433	EMULSION	0.06 mg	OPHTHALMIC	OTC monograph final	12 sections
Systane Balance	HUMAN OTC DRUG LABEL	1	0065-1433	EMULSION	0.06 mg	OPHTHALMIC	OTC monograph final	12 sections
Systane Balance	HUMAN OTC DRUG LABEL	1	0065-1433	EMULSION	0.06 mg	OPHTHALMIC	OTC monograph final	12 sections
Systane COMPLETE	HUMAN OTC DRUG LABEL	1	0065-0481	SOLUTION/ DROPS	0.06 mg	OPHTHALMIC	OTC monograph final	12 sections
Systane COMPLETE	HUMAN OTC DRUG LABEL	1	0065-0481	SOLUTION/ DROPS	0.06 mg	OPHTHALMIC	OTC monograph final	12 sections

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