Scroll

dexamethasone phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3920	2392-39-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexamethasone phosphate dexamethasone sodium phosphate decadron dexamethasone phosphoric acid	An anti-inflammatory 9-fluoro-glucocorticoid Molecular weight: 472.45 Formula: C22H30FO8P CLOGP: 0.32 LIPINSKI: 0 HAC: 8 HDO: 4 TPSA: 141.36 ALOGS: -2.21 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexamethasone phosphate
dexamethasone sodium phosphate
decadron
dexamethasone phosphoric acid

An anti-inflammatory 9-fluoro-glucocorticoid

Molecular weight: 472.45
Formula: C22H30FO8P
CLOGP: 0.32
LIPINSKI: 0
HAC: 8
HDO: 4
TPSA: 141.36
ALOGS: -2.21
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.08 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Sept. 2, 1959	FDA	MERCK

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neutrophil count decreased	248.36	15.61	150	12713	56256	63419903
Febrile neutropenia	205.62	15.61	179	12684	118270	63357889
Platelet count decreased	144.63	15.61	146	12717	115976	63360183
Myelosuppression	122.53	15.61	70	12793	23633	63452526
Interstitial lung disease	116.30	15.61	98	12765	61810	63414349
White blood cell count decreased	101.98	15.61	133	12730	138971	63337188
Bone marrow failure	101.49	15.61	67	12796	29223	63446936
Hepatic function abnormal	87.16	15.61	67	12796	37075	63439084
Anaphylactic shock	84.15	15.61	55	12808	23578	63452581
Neutropenia	77.33	15.61	132	12731	174873	63301286

Showing 1 to 10 of 92 entries

Previous1 2 3 4 5…10Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Choroiditis	195.10	16.46	52	13005	1163	34942711
Endophthalmitis	190.24	16.46	65	12992	3443	34940431
Neutrophil count decreased	187.32	16.46	154	12903	50950	34892924
Intraocular pressure increased	149.30	16.46	61	12996	5322	34938552
Platelet count decreased	142.23	16.46	198	12859	119519	34824355
Febrile neutropenia	126.20	16.46	201	12856	136648	34807226
White blood cell count decreased	122.57	16.46	164	12893	95281	34848593
Myelosuppression	112.90	16.46	77	12980	19188	34924686
Interstitial lung disease	112.38	16.46	130	12927	65152	34878722
Uveitis	108.44	16.46	54	13003	7481	34936393

Showing 1 to 10 of 58 entries

Previous1 2 3 4 5 6Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neutrophil count decreased	379.97	14.50	274	23517	93685	79626912
Febrile neutropenia	307.53	14.50	361	23430	230638	79489959
Platelet count decreased	280.49	14.50	317	23474	194347	79526250
Myelosuppression	216.05	14.50	140	23651	40156	79680441
White blood cell count decreased	201.63	14.50	264	23527	188024	79532573
Interstitial lung disease	190.98	14.50	200	23591	112400	79608197
Choroiditis	190.40	14.50	50	23741	1331	79719266
Endophthalmitis	166.01	14.50	65	23726	6363	79714234
Bone marrow failure	132.82	14.50	115	23676	50992	79669605
Hepatic function abnormal	131.34	14.50	134	23657	72973	79647624

Showing 1 to 10 of 153 entries

Previous1 2 3 4 5…16Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
CHEBI has role	CHEBI:63562	glucocorticoid receptor agonists
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:35705	immunosuppressive agents
CHEBI has role	CHEBI:37962	adrenergic agents
CHEBI has role	CHEBI:50919	antiemetico
CHEBI has role	CHEBI:78298	environmental contaminants
FDA EPC	N0000175576	Corticosteroid
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists

Showing 1 to 10 of 19 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

Show entries

Search:

Species	Use	Relation
Cats	Inflammation	Indication
Cattle	Primary bovine ketosis	Indication
Cattle	Inflammation	Indication
Dogs	Inflammation	Indication
Horses	Inflammation	Indication

Showing 1 to 5 of 5 entries

Previous1Next

🐶 Veterinary products

Show entries

Search:

Product	Applicant	Ingredients
Dex-A-Vet Injection	Bimeda Animal Health Limited	1
Dex-A-Vet Injection	Bimeda Animal Health Limited	1
Dexamethasone Sodium Phosphate Inj.	Cronus Pharma Specialities India Private Limited	1
Dexium-SP	Bimeda Animal Health Limited	1

Showing 1 to 4 of 4 entries

Previous1Next

Acid dissociation constants calculated using MoKa v3.0.0

Show entries

Search:

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.75	acidic
pKa2	6.8	acidic
pKa3	11.06	acidic
pKa4	13.94	acidic

Showing 1 to 4 of 4 entries

Previous1Next

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	IC50	9.30	CHEMBL	CHEMBL
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN		Ki	9.44	CHEMBL
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN		Ki	5.85	CHEMBL
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN		Ki	6.25	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		Ki	4.79	CHEMBL
Fatty acid-binding protein, liver	Unclassified		FABPL_RAT		Ki	4.66	CHEMBL
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	5.52	CHEMBL
Glucocorticoid receptor	Transcription factor		GCR_RAT		IC50	7.66	CHEMBL

Showing 1 to 8 of 8 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
DEX	PDB_CHEM_ID
002174	NDDF
002176	NDDF
002177	NDDF
227682	RXNORM
2BP70L44PR	UNII
312-93-6	SECONDARY_CAS_RN
3245	MMSL
35380	MMSL
372584003	SNOMEDCT_US

Showing 1 to 10 of 40 entries

Previous1 2 3 4Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9841	INJECTION, SOLUTION	4 mg	INTRA-ARTICULAR	ANDA	12 sections
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9841	INJECTION, SOLUTION	4 mg	INTRA-ARTICULAR	ANDA	12 sections
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9842	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	11 sections
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9842	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	11 sections
DEXAMETHASONE SODIUM PHOSPHATE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9843	INJECTION, SOLUTION	4 mg	INTRAVENOUS	ANDA	9 sections
DEXAMETHASONE SODIUM PHOSPHATE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9843	INJECTION, SOLUTION	4 mg	INTRAVENOUS	ANDA	9 sections
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	0641-0367	INJECTION	10 mg	INTRAMUSCULAR	ANDA	13 sections
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6145	INJECTION	4 mg	INTRA-ARTICULAR	ANDA	13 sections
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6146	INJECTION	4 mg	INTRA-ARTICULAR	ANDA	13 sections
Dexamethasone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	1	11695-1411	SOLUTION/ DROPS	1 mg	OPHTHALMIC	ANDA	15 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next