blonanserin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
serotonin receptor antagonists (mostly 5-HT2)	388	132810-10-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

blonanserin
lonasen
AD-5423

Molecular weight: 367.51
Formula: C23H30FN3
CLOGP: 6.73
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 19.37
ALOGS: -4.01
ROTB: 3

Drug dosage:

None

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.93 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Jan. 25, 2008	PMDA	Dainippon Sumitomo Pharma Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Psychiatric symptom	81.18	48.86	16	441	5207	63483358
Salivary hypersecretion	52.80	48.86	12	445	7654	63480911
Parkinsonism	49.11	48.86	12	445	10427	63478138

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Procedural failure	49.29	43.41	6	283	67	34956575
Floppy iris syndrome	48.32	43.41	7	282	310	34956332

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Psychiatric symptom	97.77	41.35	21	825	7014	79736528
Hallucination, auditory	66.18	41.35	19	827	20674	79722868
Salivary hypersecretion	54.27	41.35	15	831	14209	79729333
Procedural failure	46.50	41.35	6	840	84	79743458
Floppy iris syndrome	45.57	41.35	7	839	356	79743186
Pneumonia aspiration	44.35	41.35	19	827	66948	79676594
Parkinsonism	43.21	41.35	13	833	16571	79726971

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Schizophrenia	indication	58214004	DOID:5419

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.05	Basic
pKa2	5.85	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	ANTAGONIST	Ki	9.85		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	9.09		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.54		WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.25		WOMBAT-PK

External reference:

ID	Source
D01176	KEGG_DRUG
C0287983	UMLSCUI
CHEBI:31296	CHEBI
CHEMBL178803	ChEMBL_ID
DB09223	DRUGBANK_ID
C079310	MESH_SUPPLEMENTAL_RECORD_UI
125564	PUBCHEM_CID
7670	IUPHAR_LIGAND_ID
7563	INN_ID
AQ316B4F8C	UNII

Pharmaceutical products:

None