velnacrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 3848 124027-47-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • velnacrine
  • velnacrine maleate
  • Molecular weight: 214.27
  • Formula: C13H14N2O
  • CLOGP: 1.64
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 59.14
  • ALOGS: -2.39
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.53 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme IC50 6.79 CHEMBL
Acetylcholinesterase Enzyme IC50 7.22 CHEMBL
Acetylcholinesterase Enzyme IC50 6.44 CHEMBL
Acetylcholinesterase Enzyme IC50 6 CHEMBL
Butyrylcholinesterase Enzyme IC50 7.27 CHEMBL

External reference:

IDSource
D06288 KEGG_DRUG
118909-22-1 SECONDARY_CAS_RN
C0078151 UMLSCUI
CHEBI:91990 CHEBI
CHEMBL51934 ChEMBL_ID
CHEMBL23455 ChEMBL_ID
C056424 MESH_SUPPLEMENTAL_RECORD_UI
6403 INN_ID
Y2P6NV151K UNII
3655 PUBCHEM_CID

Pharmaceutical products:

None