velnacrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
acridine derivatives	3848	124027-47-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

velnacrine
velnacrine maleate

Molecular weight: 214.27
Formula: C13H14N2O
CLOGP: 1.64
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 59.14
ALOGS: -2.39
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D002800	Cholinesterase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.53	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.79		CHEMBL
Acetylcholinesterase	Enzyme		ACES_MOUSE		IC50	6		CHEMBL
Acetylcholinesterase	Enzyme		ACES_RAT		IC50	6.44		CHEMBL
Acetylcholinesterase	Enzyme		ACES_ELEEL		IC50	7.22		CHEMBL
Butyrylcholinesterase	Enzyme		Q9N1N9_HORSE		IC50	7.27		CHEMBL

External reference:

ID	Source
D06288	KEGG_DRUG
C0078151	UMLSCUI
CHEBI:91990	CHEBI
CHEMBL51934	ChEMBL_ID
3655	PUBCHEM_CID
C056424	MESH_SUPPLEMENTAL_RECORD_UI
6403	INN_ID
118909-22-1	SECONDARY_CAS_RN
Y2P6NV151K	UNII
CHEMBL23455	ChEMBL_ID

Pharmaceutical products:

None