antrafenine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
analgesics, glafenine derivatives (subgroup of fenamic acid group) 3677 55300-29-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • antrafenine dihydrochloride
  • antrafenine hydrochloride
  • antrafenine
  • stakane
  • Molecular weight: 588.55
  • Formula: C30H26F6N4O2
  • CLOGP: 8.96
  • LIPINSKI: 2
  • HAC: 6
  • HDO: 1
  • TPSA: 57.70
  • ALOGS: -5.32
  • ROTB: 10

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BLK,BMX,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,CSF1R,DDR1,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,ERBB4,FLT3,FYN,GAK,GRK2,INSR,ITK,JAK1,JAK2,JAK3,KDR,KIT,LCK,LYN,MAP3K1,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK1,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,SRC,STK33,SYK,TEK,TGFBR1,TNIK,TTK,TYRO3,ULK1,ULK2,YES1 81
kinase-selectivity-class ACVR2B,AXL,BRAF,DDR1,EPHB4,MARK4,PDK4,SIK2,SIK3 9
pfas-class PFAS structural alert (1 = True, 0 = False) 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.22 Basic
pKa2 6.12 Basic
pKa3 0.05 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0052135 UMLSCUI
CHEBI:135841 CHEBI
CHEMBL345524 ChEMBL_ID
DB01419 DRUGBANK_ID
C017014 MESH_SUPPLEMENTAL_RECORD_UI
3939 INN_ID
21FS93Y6OE UNII
68723 PUBCHEM_CID

Pharmaceutical products:

None