AI ASSISTANT
Ask DrugCentral
Explore drug information in your own words.
Type a question in the search bar above to get started. Each question is answered independently.
Try a sample question
Select a question to fill the search bar, then submit it or edit it first.
AI can make mistakes. Verify answers against the original sources before relying on them.
uridine triphosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3639 | 63-39-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1 | 45 | |||
| kinase-selectivity-class | AXL,BRAF,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK7,MAPK8,PIK3CB,PRKDC,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 25 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.0 | acidic |
| pKa2 | 3.35 | acidic |
| pKa3 | 6.05 | acidic |
| pKa4 | 9.23 | acidic |
| pKa5 | 11.76 | acidic |
| pKa6 | 13.81 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| P2Y purinoceptor 4 | GPCR | AGONIST | EC50 | 6.30 | IUPHAR | ||||
| P2Y purinoceptor 6 | GPCR | AGONIST | EC50 | 5.20 | IUPHAR | ||||
| P2Y purinoceptor 2 | GPCR | AGONIST | EC50 | 8.10 | IUPHAR | ||||
| P2Y purinoceptor 11 | GPCR | AGONIST | EC50 | 5.20 | IUPHAR | ||||
| P2X purinoceptor 3 | Ion channel | Ki | 5.58 | PDSP | |||||
| P2Y purinoceptor 4 | GPCR | AGONIST | EC50 | 5.60 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| CHEBI:15713 | CHEBI |
| CHEMBL336296 | ChEMBL_ID |
| DB04005 | DRUGBANK_ID |
| C0042010 | UMLSCUI |
| D014544 | MESH_DESCRIPTOR_UI |
| UTP | PDB_CHEM_ID |
| 6133 | PUBCHEM_CID |
| 1734 | IUPHAR_LIGAND_ID |
| 05161190OB | UNII |
| 2J9UL5LN5R | UNII |
| GM3E161I3C | UNII |
| KP113C7B9H | UNII |
| UT0S826Z60 | UNII |
Pharmaceutical products:
None