uridine triphosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3639 63-39-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • uridine triphosphate
  • UTP
  • uteplex
Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
  • Molecular weight: 484.14
  • Formula: C9H15N2O15P3
  • CLOGP: -4.61
  • LIPINSKI: 2
  • HAC: 17
  • HDO: 7
  • TPSA: 258.92
  • ALOGS: -1.76
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:75772 baker's yeast metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.0 acidic
pKa2 3.35 acidic
pKa3 6.05 acidic
pKa4 9.23 acidic
pKa5 11.76 acidic
pKa6 13.81 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
P2Y purinoceptor 2 GPCR AGONIST EC50 8.10 IUPHAR
P2Y purinoceptor 4 GPCR AGONIST EC50 6.30 IUPHAR
P2Y purinoceptor 6 GPCR AGONIST EC50 5.20 IUPHAR
P2Y purinoceptor 11 GPCR AGONIST EC50 5.20 IUPHAR
P2X purinoceptor 3 Ion channel Ki 5.58 PDSP
P2Y purinoceptor 4 Unclassified AGONIST EC50 5.60 IUPHAR

External reference:

IDSource
C0042010 UMLSCUI
CHEBI:15713 CHEBI
UTP PDB_CHEM_ID
CHEMBL336296 ChEMBL_ID
D014544 MESH_DESCRIPTOR_UI
DB04005 DRUGBANK_ID
6133 PUBCHEM_CID
1734 IUPHAR_LIGAND_ID
05161190OB UNII
GM3E161I3C UNII
KP113C7B9H UNII
UT0S826Z60 UNII

Pharmaceutical products:

None