troxacitabine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nucleosides antiviral or antineoplastic agents, cytarabine or azacitidine derivatives 3635 145918-75-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • troxacitabine
  • troxatyl
  • alpha-L-Dioxolane-C
  • Molecular weight: 213.19
  • Formula: C8H11N3O4
  • CLOGP: -1.77
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 97.38
  • ALOGS: -1.16
  • ROTB: 2

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.40 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 82 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D019380 Anti-HIV Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D044966 Anti-Retroviral Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000998 Antiviral Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.25 acidic
pKa2 4.18 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06255 KEGG_DRUG
C0877874 UMLSCUI
CHEBI:134886 CHEBI
LTT PDB_CHEM_ID
CHEMBL359164 ChEMBL_ID
C074908 MESH_SUPPLEMENTAL_RECORD_UI
7886 INN_ID
DB04961 DRUGBANK_ID
60KQZ0388Y UNII
454194 PUBCHEM_CID

Pharmaceutical products:

None