triclocarban Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3630 101-20-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triclocarban
  • solubacter
  • procutene
  • trichlorocarbanilide
  • trichlorcarban
bacteriostat; antiseptic in soaps & other cleansing solns; germicide; structure
  • Molecular weight: 315.58
  • Formula: C13H9Cl3N2O
  • CLOGP: 5.47
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 2
  • TPSA: 41.13
  • ALOGS: -5.04
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D004785 Environmental Pollutants
MeSH PA D014874 Water Pollutants, Chemical
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.93 acidic
pKa2 12.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bifunctional epoxide hydrolase 2 Enzyme IC50 7.89 CHEMBL
Epoxide hydrolase 1 Unclassified IC50 6.92 CHEMBL
Epoxide hydrolase; Epoxide hydrolase EphB Enzyme IC50 6.66 CHEMBL
Epoxide hydrolase 1 Unclassified IC50 6.44 CHEMBL

External reference:

IDSource
D06223 KEGG_DRUG
C1529446 UMLSCUI
CHEBI:48347 CHEBI
9EG PDB_CHEM_ID
CHEMBL1076347 ChEMBL_ID
C009540 MESH_SUPPLEMENTAL_RECORD_UI
2017 INN_ID
DB11155 DRUGBANK_ID
BGG1Y1ED0Y UNII
7547 PUBCHEM_CID
38609 RXNORM
003183 NDDF
23701001 SNOMEDCT_US
411346009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dial Gold BarAntibacterial Deodorant Soap HUMAN OTC DRUG LABEL 1 10889-100 SOAP 0.60 1 CUTANEOUS OTC monograph not final 8 sections
DG BodyAntibacterial Deodorant 3.5 oz bar HUMAN OTC DRUG LABEL 1 10889-301 SOAP 0.60 1 CUTANEOUS OTC monograph not final 7 sections
Rite Aid Renewal Gold Deodorant HUMAN OTC DRUG LABEL 1 11822-8453 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
Luckyantibacterial deodorant HUMAN OTC DRUG LABEL 1 20276-048 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
Personal Care Antibacterial HUMAN OTC DRUG LABEL 1 29500-9208 SOAP 0.67 g TOPICAL OTC monograph not final 11 sections
Image Essentials Gold HUMAN OTC DRUG LABEL 1 49738-731 SOAP 0.30 g TOPICAL OTC monograph not final 8 sections
Dial antibacterial HUMAN OTC DRUG LABEL 1 51815-300 SOAP 0.34 g TOPICAL OTC monograph not final 7 sections
DialWhite HUMAN OTC DRUG LABEL 1 51815-301 SOAP 113 g TOPICAL OTC monograph not final 8 sections
Dial Aloe Aloe HUMAN OTC DRUG LABEL 1 51815-302 SOAP 1.02 g TOPICAL OTC monograph not final 8 sections
Dial Odor ArmorOdor Armor HUMAN OTC DRUG LABEL 1 51815-303 SOAP 1.02 g TOPICAL OTC monograph not final 9 sections
Antibacterial Golden Burst HUMAN OTC DRUG LABEL 1 52862-120 SOAP 0.30 g TOPICAL OTC monograph not final 11 sections
Antibacterial Ocean Fresh HUMAN OTC DRUG LABEL 1 52862-130 SOAP 0.30 g TOPICAL OTC monograph not final 11 sections
DEODORANT HUMAN OTC DRUG LABEL 1 53507-001 SOAP 0.29 g TOPICAL OTC monograph not final 7 sections
MegaFresh Antibacterial Deodorant HUMAN OTC DRUG LABEL 1 54157-101 SOAP 0.30 g TOPICAL OTC monograph not final 8 sections
Dollar General Gold HUMAN OTC DRUG LABEL 1 55910-301 SOAP 0.60 g TOPICAL OTC monograph not final 9 sections
Coralite Ultra Antibacterial Deodorant HUMAN OTC DRUG LABEL 1 65923-807 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
Antibacterial Gold HUMAN OTC DRUG LABEL 1 67510-0016 SOAP 0.10 g TOPICAL OTC monograph not final 8 sections
Antibacterial Beauty HUMAN OTC DRUG LABEL 1 67510-0017 SOAP 0.10 g TOPICAL OTC monograph not final 8 sections
1st Date antibacterial Deodorant (White) HUMAN OTC DRUG LABEL 1 70012-101 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
1st Date antibacterial Deodorant (Gold) HUMAN OTC DRUG LABEL 1 70012-102 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
1st Date antibacterial Deodorant (Green) HUMAN OTC DRUG LABEL 1 70012-103 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections