triclocarban 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3630 101-20-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triclocarban
  • solubacter
  • procutene
  • trichlorocarbanilide
  • trichlorcarban
bacteriostat; antiseptic in soaps & other cleansing solns; germicide; structure
  • Molecular weight: 315.58
  • Formula: C13H9Cl3N2O
  • CLOGP: 5.47
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 2
  • TPSA: 41.13
  • ALOGS: -5.04
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D004785 Environmental Pollutants
MeSH PA D014874 Water Pollutants, Chemical
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.93 acidic
pKa2 12.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bifunctional epoxide hydrolase 2 Enzyme IC50 7.89 CHEMBL
Epoxide hydrolase 1 Enzyme IC50 6.92 CHEMBL
Epoxide hydrolase; Epoxide hydrolase EphB Enzyme IC50 6.66 CHEMBL
Epoxide hydrolase 1 Enzyme IC50 6.44 CHEMBL

External reference:

IDSource
D06223 KEGG_DRUG
C0077072 UMLSCUI
CHEBI:48347 CHEBI
9EG PDB_CHEM_ID
CHEMBL1076347 ChEMBL_ID
DB11155 DRUGBANK_ID
C009540 MESH_SUPPLEMENTAL_RECORD_UI
7547 PUBCHEM_CID
2017 INN_ID
BGG1Y1ED0Y UNII
38609 RXNORM
003183 NDDF
23701001 SNOMEDCT_US
411346009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dial Gold BarAntibacterial Deodorant Soap HUMAN OTC DRUG LABEL 1 10889-100 SOAP 0.60 1 CUTANEOUS OTC monograph not final 8 sections
DG BodyAntibacterial Deodorant 3.5 oz bar HUMAN OTC DRUG LABEL 1 10889-301 SOAP 0.60 1 CUTANEOUS OTC monograph not final 7 sections
Rite Aid Renewal Gold Deodorant HUMAN OTC DRUG LABEL 1 11822-8453 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
Luckyantibacterial deodorant HUMAN OTC DRUG LABEL 1 20276-048 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
Personal Care Antibacterial HUMAN OTC DRUG LABEL 1 29500-9208 SOAP 0.67 g TOPICAL OTC monograph not final 11 sections
Image Essentials Gold HUMAN OTC DRUG LABEL 1 49738-731 SOAP 0.30 g TOPICAL OTC monograph not final 8 sections
Dial antibacterial HUMAN OTC DRUG LABEL 1 51815-300 SOAP 0.34 g TOPICAL OTC monograph not final 7 sections
DialWhite HUMAN OTC DRUG LABEL 1 51815-301 SOAP 113 g TOPICAL OTC monograph not final 8 sections
Dial Aloe Aloe HUMAN OTC DRUG LABEL 1 51815-302 SOAP 1.02 g TOPICAL OTC monograph not final 8 sections
Dial Odor ArmorOdor Armor HUMAN OTC DRUG LABEL 1 51815-303 SOAP 1.02 g TOPICAL OTC monograph not final 9 sections
Antibacterial Golden Burst HUMAN OTC DRUG LABEL 1 52862-120 SOAP 0.30 g TOPICAL OTC monograph not final 11 sections
Antibacterial Ocean Fresh HUMAN OTC DRUG LABEL 1 52862-130 SOAP 0.30 g TOPICAL OTC monograph not final 11 sections
DEODORANT HUMAN OTC DRUG LABEL 1 53507-001 SOAP 0.29 g TOPICAL OTC monograph not final 7 sections
MegaFresh Antibacterial Deodorant HUMAN OTC DRUG LABEL 1 54157-101 SOAP 0.30 g TOPICAL OTC monograph not final 8 sections
Dollar General Gold HUMAN OTC DRUG LABEL 1 55910-301 SOAP 0.60 g TOPICAL OTC monograph not final 9 sections
Coralite Ultra Antibacterial Deodorant HUMAN OTC DRUG LABEL 1 65923-807 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
Antibacterial Gold HUMAN OTC DRUG LABEL 1 67510-0016 SOAP 0.10 g TOPICAL OTC monograph not final 8 sections
Antibacterial Beauty HUMAN OTC DRUG LABEL 1 67510-0017 SOAP 0.10 g TOPICAL OTC monograph not final 8 sections
1st Date antibacterial Deodorant (White) HUMAN OTC DRUG LABEL 1 70012-101 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
1st Date antibacterial Deodorant (Gold) HUMAN OTC DRUG LABEL 1 70012-102 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections
1st Date antibacterial Deodorant (Green) HUMAN OTC DRUG LABEL 1 70012-103 SOAP 0.30 g TOPICAL OTC monograph not final 10 sections