taribavirin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antivirals 3582 119567-79-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • taribavirin hydrochloride
  • taribavirin
  • ribamidine
  • viramidine
  • taribavirin HCl
  • Molecular weight: 243.22
  • Formula: C8H13N5O4
  • CLOGP: -3
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 150.50
  • ALOGS: -1.34
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.606 Moderate 0.79
caco2-efflux Caco-2 efflux ratio (BA/AB) 7.295 Moderate 0.79
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.573 10^-6 cm/s Moderate 0.79
dh-clint Dog hepatocyte intrinsic clearance 1.189 uL/min/10^6 cells Moderate 0.79
dppb Dog plasma protein binding (% unbound) 87.700 % Moderate 0.79
fcs-ppb Fetal calf serum protein binding (% unbound) 82.120 % Moderate 0.79
herg hERG pIC50 3.784 pIC50 Moderate 0.79
hh-clint Human hepatocyte intrinsic clearance 1.072 uL/min/10^6 cells Moderate 0.79
hlm-clint Human liver microsomal intrinsic clearance 3.404 uL/min/mg protein Moderate 0.79
hppb Human plasma protein binding (% unbound) 60.600 % Moderate 0.79
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK1,NTRK2,PDK1,PDK2,PRKDC,TEK 21
kinase-selectivity-class CHUK,MAP2K6,PDK1 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.585 Moderate 0.79
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.901 Moderate 0.79
mh-clint Mouse hepatocyte intrinsic clearance 0.692 Moderate 0.79
mppb Mouse plasma protein binding (% unbound) 92.010 Moderate 0.79
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.051 Moderate 0.79
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.79
pppb Pig plasma protein binding (% unbound) 93.270 % Moderate 0.79
rat-kpuu-brain Rat brain Kpuu 0.009 % Moderate 0.79
rh-clint Rat hepatocyte intrinsic clearance 1.718 uL/min/10^6 cells Moderate 0.79
rh-fuinc Rat hepatocyte fraction unbound in incubation 95.780 % Moderate 0.79
rppb Rat plasma protein binding (% unbound) 92.190 % Moderate 0.79
solubility-dd Solubility at pH 7.4 in DMSO 849.180 uM Moderate 0.79

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
CHEBI has role CHEBI:22587 antiviral agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.07 acidic
pKa2 13.44 acidic
pKa3 9.07 Basic
pKa4 3.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06651 KEGG_DRUG
40372-00-7 SECONDARY_CAS_RN
C0073221 UMLSCUI
CHEBI:134989 CHEBI
CHEMBL2111108 ChEMBL_ID
DB06408 DRUGBANK_ID
CHEMBL2107375 ChEMBL_ID
C026956 MESH_SUPPLEMENTAL_RECORD_UI
451448 PUBCHEM_CID
8619 INN_ID
R3B1994K2E UNII
R1Y PDB_CHEM_ID

Pharmaceutical products:

None