tamibarotene Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
arotinoid derivatives 3580 94497-51-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tamibarotene
  • amnolake
  • Am80
has retinoid-binding activity
  • Molecular weight: 351.45
  • Formula: C22H25NO3
  • CLOGP: 6.38
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 2
  • TPSA: 66.40
  • ALOGS: -5.79
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 11, 2005 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:50741 rar alpha/beta agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute promyelocytic leukemia, FAB M3 indication 110004001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Retinoic acid receptor alpha Nuclear hormone receptor IC50 7.11 CHEMBL
Retinoic acid receptor beta Nuclear hormone receptor AGONIST EC50 6.63 IUPHAR
Retinoic acid receptor gamma Nuclear hormone receptor AGONIST EC50 6.23 IUPHAR

External reference:

IDSource
D01418 KEGG_DRUG
C0051533 UMLSCUI
CHEBI:32181 CHEBI
A80 PDB_CHEM_ID
CHEMBL25202 ChEMBL_ID
108143 PUBCHEM_CID
C061133 MESH_SUPPLEMENTAL_RECORD_UI
7349 INN_ID
DB04942 DRUGBANK_ID
08V52GZ3H9 UNII
2648 IUPHAR_LIGAND_ID

Pharmaceutical products:

None